ARUGA Jun 有賀純

Researcher Number	10232076
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 教授
Affiliation (based on the past Project Information) *help	2014 – 2024: 長崎大学, 医歯薬学総合研究科(医学系), 教授 2017: 長崎大学, 医歯薬学総合研究科, 教授 2013: 独立行政法人理化学研究所, 脳科学総合研究センター, 客員研究員 2013: 長崎大学, 医歯(薬)学総合研究科, 教授 2009 – 2011: The Institute of Physical and Chemical Research, 行動発達障害研究チーム, チームリーダー … More 2003 – 2005: 独立行政法人理化学研究所, 比較神経発生研究チーム, チームリーダー 1999 – 2002: 理化学研究所, 発生神経生物研究チーム, 研究員 1998: The Institute of Physical and Chemical Rescarch, Researcher, ライフサイエンス筑波研究センター, 研究員 1993 – 1998: 理化学研究所, 分子神経生物学研究室, 研究員 1997: 大阪大学, 理化学研究所・ライフサイエンス筑波研究センター, 研究員 1995 – 1996: 理化学研究所, ライフサイエンス筑波研究センター, 研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / Basic Section 46010:Neuroscience-general-related / Nerve anatomy/Neuropathology / Developmental biology / Neurochemistry/Neuropharmacology / Medium-sized Section 53:Organ-based internal medicine and related fields / General anatomy (including histology/embryology) / General medical chemistry / Biological Sciences / Functional biochemistry / Neuroscience in general / Neuroscience in general … More Except Principal Investigator … More Neurochemistry/Neuropharmacology / Developmental biology Less
Keywords	Principal Investigator 神経発生 / 転写因子 / Zic / 遺伝子ターゲッティング / 小脳 / 疾患モデル動物 / 遺伝子発現調節 / 遺伝子発現制御 / 行動異常 / 形態形成 … More / トランスジェニックマウス / 転写調節 / 二分脊椎 / 遺伝子ターゲティング / 神経細胞分化 / 組織特異的遺伝子発現 / シナプス接着分子 / タンパク質間相互作用 / 神経回路形成 / Slitrk / 転写制御 / 精神神経疾患 / Zic2 / 神経堤 / 発達障害 / neural development / てんかん / シナプス形成 / 神経発達障害 / zincフィンガー / zincフィンガータンパク質 / 蛋白質・蛋白質間相互作用 / マイクロアレイ解析 / ニューロトロフィン / 神経突起伸展 / Brachyury / 脊髄 / 行動解析 / 左右軸 / DNA結合活性 / ツメガエル胚 / 全前脳症 / 神経管閉鎖不全症 / エンハンサー / Gli / Zic1 / 神経管翼板 / 遺伝子導入 / 背腹軸 / アデノウイルスベクター / 双極性障害 / LRR膜貫通タンパク質 / セロトニン性神経細胞 / 抑うつ障害 / 不安障害 / 脳腸相関 / 遺伝子改変マウス / 過敏性腸症候群 / 機能性ディスペプシア / 機能性消化管障害 / 神経疾患 / モノアミン / 拡散性伝達 / 薬理学 / シグナル伝達 / 生体分子 / 神経科学 / 脳神経疾患 / シナプス / タンパク質リン酸化 / 遺伝子変異 / タンパク質間結合 / 膜タンパク質 / シナプス伝達 / 多動症 / 血液脳関門 / 高脂血症 / 発生 / 脳血管系 / 間葉性幹細胞 / 動脈硬化 / 虚血性脳疾患 / 神経血管ユニット / congenital anomaly / protein modification / transcriptional complex / gene targeting / cell differentiation / transcription factor / 細胞内局在 / 蛋白質間相互作用 / 構造生物学 / 動物発生 / 先天性奇形 / タンパク質修飾 / 転写複合体 / 細胞分化 / mechanism of bio-signal transduction / microarray analysis / gene targetin / protein-protein interaction / transcriptional regulation / zinc finger protein / 骨格形成 / 神経突起伸展制御 / シグナル伝達機構 / 蛋白質-蛋白質間相互作用 / Znフィンガー蛋白質 / タンパク質分解制御 / 扁桃体 / 恐怖記憶 / 攻撃行動 / 遺伝子変異マウス / 扁桃体海馬野 / 高次脳機能 / 神経栄養因子 / シナプス膜タンパク質 / 感覚障害 / 疎水性相互作用 / 分子系統解析 / 分子進化 / zinc finger / タンパク質機能ドメイン / 高次脳機能障害 / 膜貫通タンパク質 / 空間記憶 / 認知障害 / 統合失調症 / グルタミン酸受容体 / 抑制性シナプス / LRR膜タンパク質 / 比較ゲノム解析 / 脳の多様性 / 比較ゲノム / 系統発生 / 進化 / 大脳皮質 / 視床 / 神経組織領域化 / 神経突起 / 膜貫通蛋白質 / 骨発生 / 網膜神経細胞 / 両眼視 / zincフィンガー蛋白質 / 視交叉 / 神経軸索走向 / 膜貫通型蛋白質 / Nodal / ツメガエル / ミュータントマウス / 突然変異マウス / 中胚葉 / 左右非対称性 / Zic3 / 左右軸決定 / Zicファミリー / 驚愕反応 / 神経管閉鎖不全 / 第8脳神経 / 胚性幹細胞 / データベース / Cre組換え酵素 / プロモーター / 神経系細胞株 / 遺伝子発現調節領域 / 前面脳症 / 椎骨発生 / 骨格異常 / 神経提 / 神経板 / 先天奇型 / ソニックヘッジホッグ / 椎骨 / 遺伝子治療 / 遺伝子タ-デティング / 神経上皮 / 小脳顆粒細胞 / 遺伝子相同組換え / ZIC / 細胞内Ca^<2+> / ダアニル酸環状化酵素 / cGMP依存性蛋白質リン酸化酵素 / cGMP … More Except Principal Investigator エンドサイトーシス / イノシトールポリリン酸 / シナプトタグミン / マウス胚操作 / エピブラスト幹細胞 / ノード / 胚発生 / 体細胞系列 / 幹細胞 / エピブラスト / 転写因子 / 遺伝子発現調節 / amyloid precursor protein / Alzheimeis disease / clathrin assembly protein / inositol polyphosphate / endocytosis / exocytosis / synaptic vesicle / synaptotagmin / イノシトール6リン酸 / ラット交感神経節細胞 / シナプス連絡 / アミロイド前駆体蛋白質 / アルツハイマー病 / クラスリン集合蛋白質 / エキソサイトーシス / シナプス小胞 / Endocytosis / Neurotransmitter Release / Inositol Polyphosphate / Synaptotagmin / 神経伝達物質放出 Less

LRR膜タンパク質によるセロトニン性神経系の発達制御の破綻による病態の解明Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Nagasaki University
How are synaptic adhesion molecules involved in functional gastrointestinal disorders?Principal Investigator
- Principal Investigator
  
  Aruga Jun
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Nagasaki University
Mechanism underlying the regulation of diffuse transmission by LRR transmembrane proteinsPrincipal Investigator
- Principal Investigator
  
  Aruga Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Nagasaki University
Altered molecular interaction between LRR synapse organizer and metabotropic receptors as a core mechanism for neurodevelopmental disordersPrincipal Investigator
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagasaki University
Development of the blood vessel regeneration system utilizing Zic family proteinsPrincipal Investigator
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Nagasaki University
Gene regulatory network underlying epiblast cell determination and their derivation into various somatic cell lineages
- Principal Investigator
  
  KONDOH Hisato
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Developmental biology
- Research Institution
  Kyoto Sangyo University
近視難聴合併症とシナプス病態の関連の解明Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Clarification of the physiological role of amygdalohippocampal areaPrincipal Investigator
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagasaki University
  Institute of Physical and Chemical Research
Clarification of the pathogenesis of the neurological disorders caused by impaired neuronal leucine-rich-repeat-containing transmembrane proteins.Principal Investigator
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research
フィンガー間相互作用を用いたバイオセンサーの開発Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
動物の進化系統発生におけるZicファミリーの意義Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Molecular basis of Zic-mediated developmental controlPrincipal Investigator
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  RIKEN
脳特異的新規膜貫通蛋白質ファミリーの神経発生における役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
脳特異的新規膜貫通蛋白質ファミリーの神経発生における役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
脊椎動物Zicファミリーの形態形成における役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
脊推動物Zicファミリーの形態形成における役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
脳の左右非対称性の分子発生学的基盤の解明Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research
Molecular basis of Zic proteins-mediated developmental regulation.Principal Investigator
- Principal Investigator
  
  ARUGA Jun
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research
脊髄動物Zicファミリーの形態形成における役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The Institute of Physical and Chemical Research
モデル動物を用いた全前脳症、神経管閉鎖不全症、精神疾患の分子遺伝学的解析Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
脊椎動物の形態形成におけるZicファミリーの役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The Institute of Physical and Chemical Research
神経系細胞の多様性を決定する遺伝子発現調節領域の系統的探索法の開発Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Zicファミリーによる神経管背側の形態形成の制御機構Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Developmental biology
- Research Institution
  The Institute of Physical and Chemical Research
小脳のパターン形成・機能回路発達における形態形成関連遺伝子群の役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The Institute of Physical and Chemical Research
脊椎運動の背腹、肢芽のパターン形成におけるZic遺伝子の役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The Institute of Physical and Chemical Research
小脳のパターン形成・機能回路発達における形態形成関連遺伝子郡の役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
ソニックヘッジホッグによる形態形成関連遺伝子Zicの発現調節機構Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Developmental biology
- Research Institution
  The Institute of Physical and Chemical Research
Involvement of Inositol Polyphosphates in Neurotermuinal Mechanism and Analysis of the Molecular Mechanism
- Principal Investigator
  
  NIINOBE Michio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka University
哺乳類小脳をモデル系とした神経回路網形成の分子機構の解明Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
アデノウイルスベクターを用いたニューロンサブタイプ決定機構の解析Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
哺乳類小脳をモデル系とした中枢シナプス形成の分子機構の解明Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
神経発生を制御する転写因子、Zicの神経管形成における役割Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
Molecular Mechanism on the Block of Neurotransmitter Release with Inositol Polyphosphates
- Principal Investigator
  
  NIINOBE Michio
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka University
相同組換えによる小脳顆粒細胞の発生・分化の分子機構の解析Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The Institute of Physical and Chemical Research
cGMP依存性蛋白質燐酸化酵素の神経系特異的機能Principal Investigator
- Principal Investigator
  
  有賀純
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Zic family - Evolution, Development and Disease.2018
- Author(s)
  Aruga J
- Total Pages
  380
- Publisher
  Springer Nature
- ISBN
  9789811073106
- Data Source
  KAKENHI-PROJECT-16H04666
[Journal Article] Human mutations in SLITRK3 implicated in GABAergic synapse development in mice.2024
- Author(s)
  Efthymiou, S., W. Han, M. Ilyas, J. Li, Y. Yu, M. Scala, N.T. Malintan, M. Ilyas, N. Vavouraki, K. Mankad, R. Maroofian, C. Rocca, V. Salpietro, S. Lakhani, E.J. Mallack, T.B. Palculict, H. Li, G. Zhang, F. Zafar, N. Rana, N. Takashima, H. Matsunaga, C. Manzoni, Striano, M.F. Lythgoe, J. Aruga, W. Lu, and H. Houlden
- Journal Title
  
  Front Mol Neurosci
  
  Volume: 17 Pages: 1222935-1222935
- DOI
  10.3389/fnmol.2024.1222935
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23985
[Journal Article] Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disorders.2023
- Author(s)
  Hatayama M, Aruga J.
- Journal Title
  
  Front Mol Neurosci.
  
  Volume: 15 Pages: 1080739-1080739
- DOI
  10.3389/fnmol.2022.1080739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06927, KAKENHI-PROJECT-23K23985
[Journal Article] Lrtm2 controls protein sorting in the striatal projection system and its deficiency causes disturbances in motor responses and monoamine dynamics2022
- Author(s)
  Misato Ichise, Kazuto Sakoori, Kei-ichi Katayama, Naoko Morimura, Kazuyuki Yamada, Hiroki Ozawa, Hayato Matsunaga, Minoru Hatayama, Jun Aruga
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: - Pages: 856315-856315
- DOI
  10.3389/fnmol.2022.856315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06905, KAKENHI-PROJECT-20K21605, KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-22K06429
[Journal Article] Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation2022
- Author(s)
  Katayama Kei-ichi、Morimura Naoko、Kobayashi Katsunori、Corbett Danielle、Okamoto Takehito、Ornthanalai Veravej G.、Matsunaga Hayato、Fujita Wakako、Matsumoto Yoshifumi、Akagi Takumi、Hashikawa Tsutomu、Yamada Kazuyuki、Murphy Niall P.、Nagao Soichi、Aruga Jun
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 7 Pages: 104604-104604
- DOI
  10.1016/j.isci.2022.104604
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07275, KAKENHI-PROJECT-22K06429, KAKENHI-PROJECT-23K23985
[Journal Article] SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex2022
- Author(s)
  Hatayama Minoru、Katayama Kei-ichi、Kawahara Yukie、Matsunaga Hayato、Takashima Noriko、Iwayama Yoshimi、Matsumoto Yoshifumi、Nishi Akinori、Yoshikawa Takeo、Aruga Jun
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 935-935
- DOI
  10.1038/s42003-022-03891-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07608, KAKENHI-PROJECT-20K06927, KAKENHI-PROJECT-23K23985, KAKENHI-PROJECT-23K24074
[Journal Article] Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice2021
- Author(s)
  Maekawa R, Muto H, Hatayama M, Aruga J
- Journal Title
  
  PLoS One
  
  Volume: 16 Issue: 1 Pages: e0245624-e0245624
- DOI
  10.1371/journal.pone.0245624
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21605, KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-20K06927
[Journal Article] Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes2021
- Author(s)
  Watanabe Daisuke、Nakagawa Shinsuke、Morofuji Yoichi、Toth Andrea E.、Vastag Monika、Aruga Jun、Niwa Masami、Deli Maria A.
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 9 Pages: 1484-1484
- DOI
  10.3390/pharmaceutics13091484
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-20K21605, KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-20KK0254
[Journal Article] Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease2021
- Author(s)
  Matsunaga H, Aruga J
- Journal Title
  
  Front Neural Circuits
  
  Volume: 15 Pages: 634875-634875
- DOI
  10.3389/fncir.2021.634875
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21605, KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-19K06568
[Journal Article] Sphingosine 1-phosphate signaling is involved in impaired blood-brain barrier function in ischemia-reperfusion injury.2019
- Author(s)
  Nakagawa S, Aruga J.
- Journal Title
  
  Mol Neurobiol
  
  Volume: 57 Issue: 3 Pages: 1594-1606
- DOI
  10.1007/s12035-019-01844-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-17K10838
[Journal Article] An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.2018
- Author(s)
  Odaka YS, Tohmonda T, Toyoda A, Aruga J.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 14954-14954
- DOI
  10.1038/s41598-018-33235-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16K10836
[Journal Article] Identification and characterization of novel conserved domains in metazoan Zic proteins.2018
- Author(s)
  Tohmonda, T., Kamiya, A., Ishiguro, A., Iwaki, T., Fujimi, T.J., Hatayama, M., Aruga, J.
- Journal Title
  
  Mol Biol Evol
  
  Volume: 35 Issue: 9 Pages: 2205-2229
- DOI
  10.1093/molbev/msy122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16K10836
[Journal Article] LRRシナプスオーガナイザーと神経発達障害2018
- Author(s)
  有賀　純
- Journal Title
  
  BIO INDUSTRY
  
  Volume: 35 Pages: 24-33
- Data Source
  KAKENHI-PROJECT-16H04666
[Journal Article] Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.2018
- Author(s)
  Ishiguro A, Hatayama M, Otsuka MI, Aruga J
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 2140-2140
- DOI
  10.1038/s41598-018-20242-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04666
[Journal Article] Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.2017
- Author(s)
  Morimura, N., Yasuda, H., Yamaguchi K., Katayama, K., Hatayama, M., Tomioka, N.H., Odagawa, M., Kamiya, A., Iwayama, Y., Maekawa, M., Nakamura, K., Matsuzaki, H., Tsujii, M., Yamada, K., Yoshikawa, T., Aruga, J.
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中
- NAID
  130007901310
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15019
[Journal Article] Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice2017
- Author(s)
  Morimura Naoko、Yasuda Hiroki、Yamaguchi Kazuhiko、Katayama Kei-ichi、Hatayama Minoru、Tomioka Naoko H.、Odagawa Maya、Kamiya Akiko、Iwayama Yoshimi、Maekawa Motoko、Nakamura Kazuhiko、Matsuzaki Hideo、Tsujii Masatsugu、Yamada Kazuyuki、Yoshikawa Takeo、Aruga Jun
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 15800-15800
- DOI
  10.1038/ncomms15800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06789, KAKENHI-PROJECT-17K01982, KAKENHI-PROJECT-16K18878, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16H05373, KAKENHI-PROJECT-26430003, KAKENHI-PROJECT-26590161, KAKENHI-PROJECT-15K09814
[Journal Article] Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice2017
- Author(s)
  Morimura, N., Yasuda, H., Yamaguchi K., Katayama, K., Hatayama, M., Tomioka, N.H., Odagawa, M., Kamiya, A., Iwayama, Y., Maekawa, M., Nakamura, K., Matsuzaki, H., Tsujii, M., Yamada, K., Yoshikawa, T., Aruga, J.
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中
- NAID
  130007901310
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04666
[Journal Article] Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.2014
- Author(s)
  Naoko H. Tomioka, Hiroki Yasuda, Hiroyuki Miyamoto, Minoru Hatayama, Naoko Morimura, Yoshifumi Matsumoto, Toshimitsu Suzuki, Maya Odagawa, Yuri S. Odaka, Yoshimi Iwayama, Ji Won Um, Jaewon Ko, Yushi Inoue, Sunao Kaneko, Shinichi Hirose, Kazuyuki Yamada, Takeo Yoshikawa, Kazuhiro Yamakawa, Jun Aruga
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 45011-16
- DOI
  10.1038/ncomms5501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23500461, KAKENHI-ORGANIZER-24116001, KAKENHI-PLANNED-24116002, KAKENHI-PROJECT-24249060, KAKENHI-PROJECT-24621012, KAKENHI-PUBLICLY-25110736, KAKENHI-PUBLICLY-25129708, KAKENHI-PROJECT-25640026, KAKENHI-PROJECT-25670481, KAKENHI-PROJECT-26430003
[Journal Article] Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.2013
- Author(s)
  Kabayama M, Sakoori K, Yamada K, Ornthanalai VG, Ota M, Morimura N, Katayama K, Murphy NP, Aruga J.
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 33(32) Issue: 32 Pages: 12940-12953
- DOI
  10.1523/jneurosci.5717-12.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700342, KAKENHI-PUBLICLY-25110736, KAKENHI-PROJECT-25640026
[Journal Article] SLITRK6 mutations cause myopia and deafness in humans and mice2013
- Author(s)
  Mustafa Tekin
- Journal Title
  
  The Journal of Clinical Investigation
  
  Volume: 124 Issue: 5 Pages: 1-9
- DOI
  10.1172/jci65853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700457, KAKENHI-PUBLICLY-25110736
[Journal Article] GLI protein nuclear localization signal2012
- Author(s)
  M. Hatayama, J. Aruga
- Journal Title
  
  Vitamins and Hormones
  
  Volume: (in press) Pages: 88-88
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway2012
- Author(s)
  T. J. Fujimi, M. Hatayama, J. Aruga
- Journal Title
  
  Dev. Biol
  
  Volume: 361 Pages: 220-231
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Comparative anatomy of marmoset and mouse cortex from genomic expression2012
- Author(s)
  H.Mashiko, A.Yoshida, S.Kikuchi, K.Niimi, E.Takahashi, J.Aruga, H.Okano, T.Shimogori
- Journal Title
  
  J.Neurosci.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] LRRシナプスオーガナイザーと神経疾患2012
- Author(s)
  有賀純、松本圭史
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 364-369
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Comparative anatomy of marmoset and mouse cortex from genomic expression2012
- Author(s)
  H. Mashiko, A. Yoshida, S. Kikuchi, K. Niimi, E. Takahashi, J. Aruga, H. Okano, T. Shimogori
- Journal Title
  
  J. Neurosci
  
  Volume: 32 Pages: 5039-5053
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction2012
- Author(s)
  Hideto Takahashi, Kei-ichi Katayama, Kazuhiro Sohya, Hiroyuki Miyamoto, Tuhina Prasad, Yoshifumi Matsumoto, Maya Ota, Hiroki Yasuda, Tadaharu Tsumoto, Jun Aruga, Ann Marie Craig
- Journal Title
  
  Nature Neuroscience
  
  Volume: 15 Issue: 3 Pages: 389-398
- DOI
  10.1038/nn.3040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200016, KAKENHI-PROJECT-21240031, KAKENHI-PROJECT-23500461, KAKENHI-PROJECT-23700404, KAKENHI-PROJECT-23700457, KAKENHI-PROJECT-24621012, KAKENHI-PUBLICLY-23115523
[Journal Article] GLI protein nuclear localization signal2012
- Author(s)
  M.Hatayama, J.Aruga
- Journal Title
  
  Vitamins and Hormones
  
  Volume: 88(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Lrrtm1と統合失調症2012
- Author(s)
  佐郡和人、有賀純
- Journal Title
  
  分子精神医学
  
  Volume: 12 Pages: 47-49
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway2012
- Author(s)
  T.J.Fujimi, M.Hatayama, J.Aruga
- Journal Title
  
  Dev.Biol.
  
  Volume: 361 Issue: 2 Pages: 220-231
- DOI
  10.1016/j.ydbio.2011.10.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis2011
- Author(s)
  H.Pan, M.K.Gustafsson, J.Aruga, J.J.Tiedken, J.C.J.Chen, C.P.Emerson, Jr.
- Journal Title
  
  Dev.Biol.
  
  Volume: 351 Issue: 1 Pages: 120-127
- DOI
  10.1016/j.ydbio.2010.12.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation2011
- Author(s)
  Aruga J, et al
- Journal Title
  
  Neurochem Res
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Impaired Auditory-Vestibular Functions and Behavioral Abnormalities of Slitrk6-Deficient Mice2011
- Author(s)
  Y.Matsumoto, K.-i.Katayama, T.Okamoto, K.Yamada, N.Takashima, S.Nagao, J.Aruga
- Journal Title
  
  Plos One
  
  Volume: 6 Issue: 1 Pages: e16497-e16497
- DOI
  10.1371/journal.pone.0016497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031, KAKENHI-PROJECT-22300112
[Journal Article] Impaired Auditory-Vestibular Functions and Behavioral Abnormalities of Slitrk6-Deficient Mice2011
- Author(s)
  Y. Matsumoto, K.-i. Katayama, T. Okamoto, K. Yamada, N. Takashima, S. Nagao, J. Aruga
- Journal Title
  
  Plos One
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Role of BMP, FGF, Calcium Signaling, and Zic Proteins in Vertebrate Neuroectodermal Differentiation2011
- Author(s)
  J. Aruga, K. Mikoshiba
- Journal Title
  
  Neurochem. Res
  
  Volume: 36 Pages: 1286-1292
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] IP_3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos2011
- Author(s)
  Hatayama M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 410(3) Issue: 3 Pages: 520-524
- DOI
  10.1016/j.bbrc.2011.06.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-21240031
[Journal Article] A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis2011
- Author(s)
  H. Pan, M. K. Gustafsson, J. Aruga, J. J. Tiedken, J. C. J. Chen, C. P. Emerson, Jr
- Journal Title
  
  Dev. Biol
  
  Volume: 351 Pages: 120-127
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] 統合失調症モデルとしてのZic2低発現マウスと統合失調症患者にみられるZIC2の変異2011
- Author(s)
  有賀純
- Journal Title
  
  分子精神医学
  
  Volume: 11 Pages: 47-49
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia2011
- Author(s)
  N. Takashima, Y. S. Odaka, K. Sakoori, T. Akagi, T. Hashikawa, N. Morimura, K. Yamada, J. Aruga
- Journal Title
  
  Plos One
  
  Volume: 6
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] IP(3) signaling is required for cilia formation and left-right body axis determination in Xenopus embryos2011
- Author(s)
  M. Hatayama, K. Mikoshiba, J. Aruga
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 410 Pages: 520-524
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients2011
- Author(s)
  M. Hatayama, A. Ishiguro, Y. Iwayama, N. Takashima, K. Sakoori, T. Toyota, Y. Nozaki, Y. S. Odaka, K. Yamada, T. Yoshikawa, J. Aruga
- Journal Title
  
  Scientific Reports
  
  Volume: 1
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation2011
- Author(s)
  Aruga J
- Journal Title
  
  Neurochem Res
  
  Volume: 36(7) Issue: 7 Pages: 1286-92
- DOI
  10.1007/s11064-011-0422-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-21240031
[Journal Article] Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients2011
- Author(s)
  M.Hatayama, A.Ishiguro, Y.Iwayama, N.Takashima, K.Sakoori, T.Toyota, Y.Nozaki, Y.S.Odaka, K.Yamada, T.Yoshikawa, J.Aruga
- Journal Title
  
  Scientific Reports
  
  Volume: 1 Issue: 1 Pages: 16-16
- DOI
  10.1038/srep00016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Impaired Cognitive Function and Altered Hippocampal Synapse Morphology in Mice Lacking Lrrtm1, a Gene Associated with Schizophrenia2011
- Author(s)
  N.Takashima, Y.S.Odaka, K.Sakoori, T.Akagi, T.Hashikawa, N.Morimura, K.Yamada, J.Aruga
- Journal Title
  
  Plos One
  
  Volume: 6 Issue: 7 Pages: e22716-e22716
- DOI
  10.1371/journal.pone.0022716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Expression of ZIC family genes in meningiomas and other brain tumors2010
- Author(s)
  有賀純
- Journal Title
  
  BMC Cancer (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21657034
[Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain-and sex-dependent eye abnormalities in mice2010
- Author(s)
  M. Maekawa, Y. Iwayama, A. Watanabe, Y. Nozaki, T. Ohnishi, H. Ohba, M. Toyoshima, K. Hamazaki, N. Osumi, J. Aruga, T. Yoshikawa
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 402 Pages: 431-437
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Expression of ZIC family genes in meningiomas and other brain tumors2010
- Author(s)
  Aruga J, et al
- Journal Title
  
  BMC Cancer
  
  Volume: 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Characterization of the tandem CWCH2 sequence motif : a hallmark of inter-zinc finger interactions2010
- Author(s)
  M. Hatayama, J. Aruga
- Journal Title
  
  BMC Evol.Biol
  
  Volume: 10
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Expression of ZIC family genes in meningiomas and other brain tumors2010
- Author(s)
  有賀純
- Journal Title
  
  BMC Cancer (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Expression of ZIC family genes in meningiomas and other brain tumors2010
- Author(s)
  J. Aruga, Y. Nozaki, M. Hatayama, Y. S. Odaka, N. Yokota
- Journal Title
  
  BMC Cancer
  
  Volume: 10
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities2010
- Author(s)
  K. Katayama, K. Yamada, V. G. Ornthanalai, T. Inoue, M. Ota, N. P. Murphy, J. Aruga
- Journal Title
  
  Mol. Psychiatry
  
  Volume: 15 Pages: 177-184
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] トゥレット症候群とSLITRK12009
- Author(s)
  有賀純
- Journal Title
  
  分子精神医学 9
  
  Pages: 254-261
- Data Source
  KAKENHI-PROJECT-21657034
[Journal Article] トゥレット症候群とSLITRK12009
- Author(s)
  有賀純
- Journal Title
  
  分子精神医学 9
  
  Pages: 254-261
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice2009
- Author(s)
  K.-i. Katayama, A. Zine, M. Ota, Y. Matsumoto, T. Inoue, B. Fritzsch, J. Aruga
- Journal Title
  
  Plos One
  
  Volume: 4
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Stability of folding structure of Zic zinc finger proteins2009
- Author(s)
  K. Sakai-Kato, Y. Umezawa, K. Mikoshiba, J. Aruga, N. Utsunomiya-Tate
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 384 Pages: 362-365
- Data Source
  KAKENHI-PROJECT-21240031
[Journal Article] Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.2007
- Author(s)
  Inoue T, Ota M, Ogawa M, Mikoshiba K, Aruga J
- Journal Title
  
  J Neurosci 27
  
  Pages: 5461-5473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  J Biol Chem 282
  
  Pages: 9983-9995
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain.2007
- Author(s)
  Chhin B, Hatayama M, Bozon D, Ogawa M, Schon P, Tohmonda T, Sassolas F, Aruga J, Valard AG, Chen SC, Bouvagnet P
- Journal Title
  
  Hum Mutat 28
  
  Pages: 563-570
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly (ADP-ribose) polymerase, and RNA helicase A.2007
- Author(s)
  Ishiguro A, Ideta M, Mikoshiba K, Chen DJ, Aruga J
- Journal Title
  
  J Biol Chem 282
  
  Pages: 9983-9995
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.2007
- Author(s)
  Inoue T, Ota M, Mikoshiba K, Aruga J
- Journal Title
  
  Dev Biol. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain.2007
- Author(s)
  Chhin B, Hatayama M, Bozon D, Ogawa M, Schon P, Tohmonda T, Sassolas F, Aruga J, et al.
- Journal Title
  
  Hum Mutat 28
  
  Pages: 563-570
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Xenopus Zic4 : conservation and diversification of expression profiles and protein function among the Xenopus Zic family.2006
- Author(s)
  Fujimi TJ, Mikoshiba K, Aruga J
- Journal Title
  
  Dev Dyn 235
  
  Pages: 3379-3386
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] A wide-range phylogenetic analysis of Zic proteins, implications for correlations between protein structure conservation and body plan complexity.2006
- Author(s)
  J.Aruga et al.
- Journal Title
  
  Genomics (in press)
- Data Source
  KAKENHI-PROJECT-16027261
[Journal Article] A wide-range phylogenetic analysis of Zic proteins, implications for correlations between protein structure conservation and body plan complexity.2006
- Author(s)
  J.Aruga et al.
- Journal Title
  
  Genomics (in press)
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] A wide-range phylogenetic analysis of Zic proteins : implications for correlations between protein structure conservation and body plan complexity.2006
- Author(s)
  Aruga J, Kamiya A, Takahashi H, Fujimi TJ, Shimizu Y, et al.
- Journal Title
  
  Genomics 87
  
  Pages: 783-792
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] A wide-range phylogenetic analysis of Zic proteins : implications for correlations between protein structure conservation and body plan complexity.2006
- Author(s)
  Aruga J, Kamiya A, Takahashi H, Fujimi TJ, Shimizu Y, Ohkawa K, Yazawa S, Umesono Y, Noguchi H, Shimizu T, Saitou N, Mikoshiba K, Sakaki Y, Agata K, Toyoda A
- Journal Title
  
  Genomics 87
  
  Pages: 783-792
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent-tail) mutant mice.2004
- Author(s)
  Aruga, J et al.
- Journal Title
  
  Eur.J.Neurosci 20
  
  Pages: 2159-2167
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] The role of Zic genes in neural development.2004
- Author(s)
  Aruga J
- Journal Title
  
  Mol Cell Neurosci 26
  
  Pages: 205-221
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Molecular properties of Zic4 and Zic5 proteins : functional diversity within Zic family.2004
- Author(s)
  Ishiguro A, Inoue T, Mikoshiba K, Aruga J
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 302-307
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent tail) mutant mice.2004
- Author(s)
  Aruga J, Ogura H, Shutoh F, Ogawa M, Franke B, Nagao S, Mikoshiba K
- Journal Title
  
  Eur J Neurosci 20
  
  Pages: 2159-2167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent-tail) mutant mice.2004
- Author(s)
  Aruga, J et al.
- Journal Title
  
  Eur.J. Neurosci 20
  
  Pages: 2159-2167
- Data Source
  KAKENHI-PROJECT-16027261
[Journal Article] Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.2004
- Author(s)
  Inoue T, Hatayama M, Tohmonda T, Itohara S, Aruga J, Mikoshiba K
- Journal Title
  
  Dev Biol. 270
  
  Pages: 146-162
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.2004
- Author(s)
  Inoue T, Hatayama M, Tohmonda T, Itohara S, Aruga J, Mikoshiba K
- Journal Title
  
  Dev Biol 270
  
  Pages: 146-162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] Myogenic repressor I-mfa interferes with the function of Zic family proteins.2004
- Author(s)
  Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K, Aruga J
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 233-240
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Journal Article] The role of Zic genes in neural development.2004
- Author(s)
  Aruga, J
- Journal Title
  
  Mol Cell Neurosci. 26
  
  Pages: 205-221
- Data Source
  KAKENHI-PROJECT-16027261
[Journal Article] The role of Zic genes in neural development.2004
- Author(s)
  Aruga, J
- Journal Title
  
  Mol Cell Neurosci. 26
  
  Pages: 205-221
- Data Source
  KAKENHI-PROJECT-16390086
[Patent] 特許2005
- Inventor(s)
  有賀純
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2005-05-27
- Acquisition Date
  2006-12-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390086
[Presentation] Regulation of receptor chaperone molecule RTP4 in neuronal cells by opioid receptor activation2021
- Author(s)
  Fujita W, Aruga J
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03327
[Presentation] Slitrk1 regulates endocytosis in PC12 cells2019
- Author(s)
  Hatayama M, Katayama K, Aruga J
- Organizer
  The 42nd Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-19H03327
[Presentation] Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.2019
- Author(s)
  Morimura N, Yasuda H, Katayama K, Hatayama M, Yoshikawa T, Aruga J.
- Organizer
  10th IBRO World Congress of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03327
[Presentation] Role of Lrtm2 in striatal medium spiny neurons2019
- Author(s)
  Ichise M, Hatayama M, Aruga J
- Organizer
  The 42nd Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-19H03327
[Presentation] Roles of sphingosine-1 phosphate in blood-brain barrier using in vitro and in vivo ischemia reperfusion injury model.2018
- Author(s)
  Nakagawa S, Aruga J.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] Altered monoamine dynamics and abnormal behaviors in Lrtm2-deficient mice.2018
- Author(s)
  Ichise M, Katayama K, Sakoori K, Morimura N, Hatayama M, Aruga J.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] Role of Lrrn3, a brain-enriched transmembrane protein in neural development.2018
- Author(s)
  Nakamura M, Hatayama M, Nakagawa S, Aruga J.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.2018
- Author(s)
  Morimura N, Yasuda H, Katayama K, Hatayama M, Yoshikawa T, Aruga J.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] Elfn2欠損マウスに見られる代謝異常症2017
- Author(s)
  牧野まどか、富岡直子、松永隼人、有賀純
- Organizer
  第70回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] Elfn2欠損マウスに見られる代謝異常2017
- Author(s)
  牧野まどか、富岡直子、有賀　純
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] LRR膜タンパク質ファミリーによるシナプス制御とその破綻による病態2017
- Author(s)
  有賀　純
- Organizer
  第122回日本解剖学会全国学術集会
- Place of Presentation
  長崎大学坂本キャンパス（長崎県長崎市）
- Year and Date
  2017-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] てんかん・多動症患者に見られたElfn1変異体の分子機能解析2017
- Author(s)
  織方良介、牧野まどか、畑山　実、有賀　純
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] Slitrk1 regulates adrenergic innervation in prefrontal cortex (PFC) and affects anxiety/depression related behavior2017
- Author(s)
  Hatayama M, Katayama K, Takashima N, Aruga J.
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16H04666
[Presentation] Zic遺伝子ファミリーによる脳血管系の発生制御2017
- Author(s)
  渡邉新太、畑山　実、中川慎介、巽理恵、有賀　純
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K15019
[Presentation] Roles of Zic family zinc finger proteins in development and maintenance of the blood-brain-barrier2015
- Author(s)
  J. ARUGA, M. HATAYAMA, S. NAKAGAWA, R. TATSUM
- Organizer
  Society for Neuroscience Annual Meeting
- Place of Presentation
  シカゴ（米国）
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15019
[Presentation] Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.2013
- Author(s)
  M. Kabayama, K. Sakoori, K. Yamada, M. Odagawa, N. Morimura, K.-I. Katayama, N. P. Murphy, J. Aruga
- Organizer
  The 43rd annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-25640026
[Presentation] Rines E3 Ubiquitin Ligase Regulates Emotional Behaviors by Altering the Monoamine Dynamics in Prefrontal Cortex2013
- Author(s)
  Miyuki Kabayama, Kazuto Sakoori, Kazuyuki Yamada, Veravej G. Ornthanalai, Maya O. Odagawa, Naoko Morimura, Kei-ichi Katayama, Niall P. Murphy, Jun Aruga.
- Organizer
  The 36th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25640026
[Presentation] Slitrk6 is essential for timely synaptogenesis and emmetropization.2013
- Author(s)
  Aruga, J., Matsumoto, Y., Sakoori, K., Odagawa, M.O., Odaka Y.S.
- Organizer
  The 43rd annual meeting of the Society for Neuroscience (SfN 2013).
- Place of Presentation
  San Diego(USA)
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110736
[Presentation] Roles of LRR transmembrane proteins in hippocampal inhibitory neural circuit formation2013
- Author(s)
  1. Aruga, J., Tomioka, N.H., Miyamoto, H., Hatayama, M., Matsumoto, Y., Yoshikawa, T., Yamakawa, K.
- Organizer
  Cold Spring Harbor Laboratory Wiring the Brain Meeting
- Place of Presentation
  New York(USA)
- Invited
- Data Source
  KAKENHI-PUBLICLY-25110736
[Presentation] Executive function deficits and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia2011
- Author(s)
  有賀純
- Organizer
  41st Annual Meeting of the Society for Neuroscienee (Neuroscience 2011)
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Zic2の聴覚神経回路形成における役割2011
- Author(s)
  有賀純
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Molecular and pathological characterisation of an inherited condition amongst the Amish involving high myopia and sensaorineural hearing loss2011
- Author(s)
  Moore-Barton H., Chioza B. A., Matsumoto Y., Cross H., E., Sakoori K., Odagawa M., Gurtz K., Patton M. A., Aruga J., and Crosby A. H.
- Organizer
  British Human Genetics Conference 2011
- Place of Presentation
  Coventry, UK
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN2011
- Author(s)
  Matsumoto Y., Takashima N., Nozaki Y., Nishioka C., Kudoh M., and Aruga J.
- Organizer
  41st Annual Meeting of the Society for Neuroscience(Neuroscience 2011)
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Lrrtmシナプスオーガナイザーファミリー欠損マウスに見られた行動およびシナプスの異常2011
- Author(s)
  有賀純
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Executive function deficits and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia2011
- Author(s)
  Aruga J., Takashima N., Odaka Y., Sakoori K., Akagi T., Hashikawa T., Morimura N., and Yamada K
- Organizer
  41st Annual Meeting of the Society for Neuroscience(Neuroscience 2011)
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Molecular and pathological characterisation of an inherited condition amongst the Amish involving high myopia and sensorineural hearing loss2011
- Author(s)
  Moore-Barton, H., Chioza, BA., Matsumoto, Y., Cross, HE., Sakoori, K., Ota, M., Gurtz, K., Patton, MA., Aruga, J., Crosby, AH
- Organizer
  British Human Genetics Conference 2011
- Place of Presentation
  Coventry, UK
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Characterization on Elfn family in the central nervous system2011
- Author(s)
  Tomioka-Hara N., Yamada K., Odagawa M., Odaka Y., and Aruga J.
- Organizer
  41st Annual Meeting of the Society for Neuroscience(Neuroscience 2011)
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice2010
- Author(s)
  Matsumoto Y., Katayama K., Zine A., Ota M., Inoue T., Fritzsch B., Yamada K., and Aruga J.
- Organizer
  40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] A role of Rines, a neuronal membrane-bound ubiquitin ligase in higher brain function2010
- Author(s)
  Kabayama-Ogawa M., Ornthanalai V., Yamada K., Murphy N. P., Katayama K., and Aruga J.
- Organizer
  40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Zic2 hypomorphic mutant mice exhibit cognitive impairment and social behavior abnormalities with an altered distribution of basal forebrain cholinergic neurons2010
- Author(s)
  Aruga Jun
- Organizer
  40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010)
- Place of Presentation
  San Diego USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Characterisation of Slitrk2-deficient mice2010
- Author(s)
  Corbett D. C., Katayama K., Matsumoto Y., Morimura, N., Yamada K., Ota M., Ornthanalai V., Honma C., Murphy N. P., and Aruga J.
- Organizer
  40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Zic2 hypomorphic mutant mice exhibit cognitive impairment and social behavior abnormalities with an altered distribution of basal forebrain cholinergic neurons2010
- Author(s)
  Aruga J., Hatayama M., Takashima N., Sakoori K., Nozaki Y., Odaka Y., Yamada K., and Ishiguro A
- Organizer
  40th Annual Meeting of the Society for Neuroscience(Neuroscience 2010)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice2009
- Author(s)
  有賀純
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21657034
[Presentation] Slitrk6欠損マウスに見られた内耳の感覚神経発生異常2009
- Author(s)
  有賀純
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] Slitrk6欠損マウスに見られた内耳の感覚神経発生異常2009
- Author(s)
  有賀純
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21657034
[Presentation] Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice2009
- Author(s)
  有賀純
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21240031
[Presentation] 神経血管ユニットの発達過程におけるZinc finger型転写因子の役割
- Author(s)
  畑山実、日高悠希、有賀純
- Organizer
  日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25640026
[Presentation] Elfn1はmGluR7をシナプス前部に集積させ、てんかんや多動症の発症に関与する
- Author(s)
  富岡直子、安田浩樹、宮本浩行、山田一之、吉川武男、山川和弘、有賀純
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25110736
[Presentation] 探索行動を制御する神経膜タンパク質Lrtm2の分子機能
- Author(s)
  市瀬実里、片山圭一、佐郡和人、守村直子、小田川摩耶、富岡直子、山田一之、有賀純
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25110736
[Presentation] Elfn1 recruits presynaptic mGluR7 in trans and its loss cause epilepsy, hyperactivity, and attention deficits
- Author(s)
  Aruga J, Tomioka N, Yasuda H, Miyamoto H
- Organizer
  The 44th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Walter E. Washington Convention Center (Washington DC, USA)
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PUBLICLY-25110736

1. NIINOBE Michio (80135748)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. ISHIGURO Akira (70373264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. NAKAGAWA Shinsuke (10404211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. HATAYAMA Minoru (50443007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. TATSUMI Rie (40584727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KONDOH Hisato (70127083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ISHII Yasuo (20582430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKEMOTO Tatsuya (30443899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YASUDA Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. HAMABE Wakako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. Yoshikawa Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. KAWAHARA Yukie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 樺山実幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 守村直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 西昭徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 河原博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 諸藤陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ARUGA Jun 有賀 純

Research Projects

Research Products

Co-Researchers

LRR膜タンパク質によるセロトニン性神経系の発達制御の破綻による病態の解明Principal Investigator

Principal Investigator

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How are synaptic adhesion molecules involved in functional gastrointestinal disorders?Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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Mechanism underlying the regulation of diffuse transmission by LRR transmembrane proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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Altered molecular interaction between LRR synapse organizer and metabotropic receptors as a core mechanism for neurodevelopmental disordersPrincipal Investigator

Principal Investigator

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Development of the blood vessel regeneration system utilizing Zic family proteinsPrincipal Investigator

Principal Investigator

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Gene regulatory network underlying epiblast cell determination and their derivation into various somatic cell lineages

Principal Investigator

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近視難聴合併症とシナプス病態の関連の解明Principal Investigator

Principal Investigator

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Review Section

Research Institution

Clarification of the physiological role of amygdalohippocampal areaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Clarification of the pathogenesis of the neurological disorders caused by impaired neuronal leucine-rich-repeat-containing transmembrane proteins.Principal Investigator

Principal Investigator

Project Period (FY)

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フィンガー間相互作用を用いたバイオセンサーの開発Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

動物の進化系統発生におけるZicファミリーの意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular basis of Zic-mediated developmental controlPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脳特異的新規膜貫通蛋白質ファミリーの神経発生における役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

ARUGA Jun 有賀純