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Iseki Tohru  井関 徹

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ISEKI Tohru  井関 徹

ISEKI Toru  井関 徹

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Researcher Number 10232365
Affiliation (based on the past Project Information) *help 2018: 千葉大学, 医学部附属病院, 講師
2004: 千葉大学, 医学部付属病院・輸血部, 講師
2004: Chiba University, Department of Blood transfusion, Assistant Professor, 医学部附属病院・輸血部, 講師
2003: 東京大学, 医科学研究所, 講師
1999 – 2000: 東京大学, 医科学研究所, 助手
1995 – 1996: 千葉大学, 医学部, 助手
1986 – 1987: 千葉大学, 医学部, 医員
Review Section/Research Field
Except Principal Investigator
Hematology / Hematology / Gastroenterology / Urology
Keywords
Except Principal Investigator
CML / MICB / GVL / GVHD / エピジェネティクス / 血液内科学 / EZH2/1共阻害剤 / BRAF / UTX / EZH2/EZH1阻害剤 … More / 骨髄腫モデルマウス / プロテアソーム阻害剤 / EZH2/EZH1共阻害剤 / ヒストンメチル化異常 / 多発性骨髄腫 / intrinsic factor / intrinsic factor-cobalamin receptor / R-hindor / chymotrypsin / elatase / trypsin / Pancreatic enzymes / デオキシウリジン抑制テスト / 内因子 / 内因子-コバラミン受容体 / R蛋白 / キモトリプシン / エラスターゼ / トリプシン / 膵酵素 / Transplantation / Cord Blood / 遺伝子多型 / 発現解析 / NK細胞 / 血液疾患 / 臍帯血幹細胞移植 / 移植 / 臍帯血 / gene transfer / chimera hematopoiesis / cord blood cells / CD34 positive cell / xenograft / leukemia model / human hematopoiesis model / common marmoset / フローサイトメトリー / CD34 / 胎児移植 / 臍帯血細胞 / 造血キメラ / 膵帯血細胞 / CD34陽性細胞 / HLA遺伝子型 / 異種間移植 / 白血病疾患モデル / ヒト造血モデル / コモンマーモセット / liposome / Adenovirus / gene therapy / cytochrome C oxidase / antisense RNA / mitochondria / 白血病 / 抗腫瘍効果 / リボゾーム / アデノウィルス / 遺伝子治療 / アンチセンスRNA / チトクロームCオキシダーゼ / ミトコンドリア / high dose chemotherapy / blood stem cell transplantation / testicular tumor / 超大量化学療法 / 造血幹細胞移植 / 精巣腫瘍 Less
  • Research Projects

    (6 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (20 People)
  •  Epigenetic pathogenesis of multiple myeloma related to drug resistance

    • Principal Investigator
      Naoya Mimura
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Genomic study on GVHD and GVL in cord blood transplantation of adult patients.

    • Principal Investigator
      SATO Noriharu
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Feasibility of MARCO(Mitochondrial antisense RNA for cytochrome C Oxidase) for the treatment of leukerniaz

    • Principal Investigator
      SHIRATUJI Naoki
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Teikyo University School of Medicine
      The University of Tokyo
  •  Basic study towords reconstitution of normal and leukemic human hemopoiesis in small monkey of common marmoset

    • Principal Investigator
      TANI Kenzaburo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  High Dose Chemotherapy with Autologous Blood Stem Cell Transplantation for advanced testicular tumors

    • Principal Investigator
      OKANO Tatsuya
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Chiba University
  •  Role of R-binder and intrinsic factor-cobalamin receptor on cobalamin absorption.

    • Principal Investigator
      KANAZAWA Shoichiro
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University School of Medicine

All 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.2017

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama
    • Journal Title

      Clinical Cancer Research

      Volume: 23(16) Issue: 16 Pages: 4817-4830

    • DOI

      10.1158/1078-0432.ccr-16-2735

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839, KAKENHI-INTERNATIONAL-15K21751, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
  • [Presentation] Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice2018

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
    • Organizer
      The 60th ASH annual meeting (SanDiego, USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] 新規骨髄腫マウスモデルの作成2018

    • Author(s)
      リズクオラ, 三村尚也, 井関徹, 堺田惠美子, 中世古知昭, 岩間厚志
    • Organizer
      第43回日本骨髄腫学会学術集会 (千葉市)
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Loss of Utx with Braf V600E induces mature B-cell tumorigenesis in a conditional mouse model2018

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
    • Organizer
      第80回日本血液学会総会(大阪市)
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Loss of Utx Cooperates with Braf V600E Mutation to Induce Post-Germinal Center B-cell Disorders in Mice2018

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Syuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
    • Organizer
      The 9th JSH international symposium (Kyoto, Japan)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] PRC2 Inhibition Sensitizes Myeloma Cells to Proteasome Inhibitor.2016

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Changshan Wang, Tetsuhiro Chiba, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
    • Organizer
      The 5th Japanese Cancer Association (JCA) - American Association for Cancer Research (AACR) Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club Resort(千葉県浦安市)
    • Year and Date
      2016-07-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Combined inhibition of PRC2 and proteasome as a potential therapy for multiple myeloma2016

    • Author(s)
      Ola Rizq, 三村尚也, 大島基彦, 更屋敦則, 小出周平, 加藤裕子, 青山和正, 井関徹, 中世古知昭, 岩間厚志
    • Organizer
      第78回日本血液学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Molecular mechanism behind the synergistic activity of proteasome inhibition and PRC2 inhibition in the treatment of multiple myeloma.2016

    • Author(s)
      14.Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
    • Organizer
      The 58th Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego Convention Center, California, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] EZH2・EZH1阻害剤は骨髄腫細胞のボルテゾミブ感受性を増強する2016

    • Author(s)
      Ola Rizq, 三村尚也, 井関徹, 中世古知昭, 岩間厚志
    • Organizer
      第41回日本骨髄腫学会学術集会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2016-05-28
    • Data Source
      KAKENHI-PROJECT-16K09839
  • 1.  SATO Noriharu (90162461)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  OKANO Tatsuya (00185456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  ASAI Takayoshi (00134396)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SHIRATUJI Naoki (00206301)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  MATSUDA Satoru (50242110)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TANI Kenzaburo (00183864)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HAMADA Hiromi (60261799)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TANIOKA Yoshikuni (10072406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  ASANO Shigetaka (50134614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TOJO Arinobu (00211681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TAKAHASHI Satoshi (60226834)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KANAZAWA Shoichiro (70177492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KONDO Haruki (30142235)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Naoya Mimura (00422220)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 15.  Iwama Atsuhi (70244126)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 16.  Nakaseko Chiaki (30323398)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 17.  Oshima Motohiko (70506287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 18.  大井 淳 (20302606)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  WATANABE Junichiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  GOTO Moritaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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