TANIMOTO Mitsune 谷本光音

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TANIMOTO Mistune 谷本光音

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Researcher Number	10240805
Affiliation (based on the past Project Information) *help	2016 – 2017: 岡山大学, 医歯薬学総合研究科, 特命教授 2012 – 2015: 岡山大学, 医歯(薬)学総合研究科, 教授 2014: 岡山大学, 医歯薬学総合研究科, 教授 2009 – 2011: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2006 – 2007: 岡山大学, 大学院・医歯学総合研究科, 教授 … More 2006 – 2007: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2005: 岡山大学, 大学院・医歯学給合研究科, 教授 2002 – 2003: 岡山大学, 大学院・医歯学総合研究科, 教授 1998 – 2000: School of Medicine, Nagoya University Assistant Professor, 医学部, 講師 1995 – 1998: 名古屋大学, 医学部, 助手 1994: Nagoya University School of Medicine, Assistant Professor 1992 – 1993: Nagoya University School of Medicine, Assistant Professor, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology / Hematology / General fisheries / Biological Sciences
Keywords	Principal Investigator 造血幹細胞移植 / gene therapy / AAVベクター / 遺伝子導入 / 遺伝子治療 / AAV / ヒト白血病 / 同種造血幹細胞移植 / 免疫寛容 / 移植片対宿主病 … More / 制御性T細胞 / hematopoietic neoplasms / GVL effect / cell culture / cell therapy / hematopoetic cell / gene transduction / adeno associate virus / リコンビナント / ドナーリンパ球輸注 / GLV効果 / GVL効果 / 血液悪性腫瘍 / 細胞培養 / 細胞治療 / 造血細胞株 / viral vector / hematopoietic stem cells / human leukemia / AAV mediated gene transfer / 白血病細胞 / ウイルスベクター / 造血幹細胞 / Chromosome defect / Chromosome 9 / Tumor suppressor gene / Gene deletion / Molecular biology / Human leukemia / 遺伝子クローニング / 遺伝子欠失 / 染色体欠欠 / 染色体欠失 / 第9染色体 / 癌抑制性遺伝子 / 遺伝子欠損 / 分子生物学 / ＧＶＨＤ / GVHD / 人工細胞 / Fas-FasL / アポトーシス / イムノビーズ / 抗体療法 / Tリンパ球 / 細胞障害性 / 細胞療法 / 免疫療法 … More Except Principal Investigator Ryudocan / cDNA / GATA-2 / GVL / GVHD / TRIF / MyD88 / activation-induced cell death / FTY720 / graft-versus-leukemia / graft-versus-host disease / Ikaros / SYK / CEV / SEREX / 血管内皮 / 血液流動性 / Proteoglycan / Heparan Sulfate / ヘパラン硫酸 / 移植片対宿主病 / 造血幹細胞 / PML / 転写因子 / antigen presenting cells / GVL効果 / 抗原提示細胞 / plasmacvtoid dendritic cell / sphingosin-1-nhoshate / lymph nodes / dendritic cell / graft-versus-hostdisease / plasmacytoid dendritic cell / sphingosin-1-phosphate / transcription factor / hematologic malignancy / 造血器腫瘍 / DNA Vaccine / Gene Gun / Vaccine / SFV / DC / デンドリマー / マンノース / チロシンリン酸化 / PDGFR / DNAワクチン / 遺伝子銃 / ワクチン / promoter activity / ryudocan gene / heparan sulfate proteoglycan / endothelium / impaired secretion / protein S deficiency / protein C deficiency / Thrombophilia / プロテインS / プロテインC / 生理的凝固阻止因子 / プロモーター活性 / Ryudocan遺伝子 / ヘパラン硫酸プロテオグリカン / 分泌異常 / protein S欠損症 / 血栓性素因 / Immuno-histochemistry / Endothelial cell / ヒト染色体20q12 / alternative polyadenylation / Inhibition radioimmuno assay / 特異抗体 / 免疫組織染色 / Chromosomal Location / 1型膜蛋白 / プロテオグリカン / 遺伝子座 / プロラオグリカン / gene therapy / pL9RNL / retroviral vector / expression vector / factor IX / レトロウイルスベクタ- / 第IX因子 / レトロウイルスベクター / VII因子 / マウス線維芽細胞 / 第IX因子発現 / レトロウィルスベクター / 遺伝子治療 / 血友病B / レチノイド / 慢性GVHD / 同種造血幹細胞移植 / p300 / タンパク質間相互作用 / 転写活性 / TAT / HIV / 分化 / MAPキナーゼ / リン酸化 / GATA転写因子 Less

Low-dose IL-2 therapy to maintain Treg homeostasis under the use of calcineurin inhibitorPrincipal Investigator
- Principal Investigator
  
  Tanimoto Mitsune
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Okayama University
role of HMGB-1-RAGE pathway on acute GVHD
- Principal Investigator
  
  MAEDA Yoshinobu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Okayama University
The role of PD1 pathway on tolerance after allogeneic transplantationPrincipal Investigator
- Principal Investigator
  
  TANIMOTO Mitsune
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Okayama University
Synthetic Retinoid Am80 Ameliorates Chronic Graft-Versus-Host Disease by Downregulating Th1 and Th17
- Principal Investigator
  
  MAEDA Yoshinobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Okayama University
Reduced allostimulatory activity of host antigen-presenting cells regulates the severity of graft-versus-host disease while preserving a graft-versus-leukemia effect
- Principal Investigator
  
  MAEDA Yoshinobu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Okayama University
Comprehensive analysis of role of dendritic cells and target cells in graft-versus-host disease and graft-versus-leukemia
- Principal Investigator
  
  TESHIMA Takanori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Molecular analysis of Ikaros gene family in hematologic malignancy
- Principal Investigator
  
  ISHIMARU Fumihiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  OKAYAMA UNIVERSITY
細胞障害性Tリンパ球を模した細胞障害性ゼラチンビーズの開発Principal Investigator
- Principal Investigator
  
  谷本光音
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Novel immunotherapy for Hematological Malignancy
- Principal Investigator
  
  SAITO Hidehiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
転写因子とcofactorによる造血幹細胞分化モデル:GATA-2とPMLの結合
- Principal Investigator
  
  齋藤英彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
造血幹細胞においてGATA-2遺伝子産物と機能的に結合する蛋白の分離同定
- Principal Investigator
  
  齋藤英彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
HIV転写調節機構:造血幹細胞におけるGATA-2による制御
- Principal Investigator
  
  TAKAMATSU Junki
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Gene Therapy Using rAAV Vector Against Hematological Disorders : From Basic Science To Clinical Application.Principal Investigator
- Principal Investigator
  
  TANIMOTO Mitsune
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
GATA転写因子と造血細胞の増殖、分化および造血器腫瘍の成因に関する研究
- Principal Investigator
  
  SAITO Hidehiko
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
Molecular Biological Analysis for Mechanism of Thombosis Regulation and Its APlication for Clinical Desease.
- Principal Investigator
  
  SAITO Hidehiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Basic research of Adeno-associated virus (AAV) mediated gene transfer against human leukemia.Principal Investigator
- Principal Investigator
  
  TANIMOTO Mitsune
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  NAGOYA UNIVERSITY,SCHOOL OF MEDICINE
Molecular and Pathological Analysis of Anticoagulant Heparan Sulfate Proteoglycan from Endothelial Cell
- Principal Investigator
  
  SAITO Hidehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Molecular and Pathological Analysis of Anticoagulant Heparan Sulfate Proteoglycan from Endothelial Cell
- Principal Investigator
  
  TAKAMATSU Junki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General fisheries
- Research Institution
  Nagoya University
Dectection of leukemia-associate antioncogene located on the long-arm of human chromosome 9.Principal Investigator
- Principal Investigator
  
  TANIMOTO Mitsune
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Investigation on gene therapy for congenital bleeding tendency
- Principal Investigator
  
  SAITO Hidehiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University

All 2017 2016 2013 2010 2007

All Journal Article Presentation

[Journal Article] PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.2017
- Author(s)
  Asano T, Meguri Y, Yoshioka T, Kishi Y, Iwamoto M, Nakamura M, Sando Y, Yagita H, Koreth J, Kim HT, Alyea EP, Armand P, Cutler CS, Ho VT, Antin JH, Soiffer RJ, Maeda Y, Tanimoto M, Ritz J, Matsuoka KI.
- Journal Title
  
  Blood
  
  Volume: 129 Issue: 15 Pages: 2186-2197
- DOI
  10.1182/blood-2016-09-741629
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461449, KAKENHI-PROJECT-15K09504
[Journal Article] Treatment of thrombotic microangiopathy after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin2016
- Author(s)
  Fujiwara H, Maeda Y, Sando Y, Nakamura M, Tani K, Ishikawa T, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanimoto M.
- Journal Title
  
  Transfusion
  
  Volume: 56 Issue: 4 Pages: 886-92
- DOI
  10.1111/trf.13437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09504, KAKENHI-PROJECT-26461449
[Journal Article] Vigorous inflammatory responses in noninfectious pulmonary complication induced by donor lymphocyte infusion.2016
- Author(s)
  Nishie M, Fujii N, Mimura Y, Asano T, Mimura-Kimura Y, Aoe K, Aoe M, Nakashima H, Fujiwara H, Nishimori H, Matsuoka K, Kondo E, Maeda Y, Tanimoto M.
- Journal Title
  
  Transfusion
  
  Volume: 56 Issue: 1 Pages: 231-6
- DOI
  10.1111/trf.13283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09504, KAKENHI-PROJECT-26461449
[Journal Article] Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice.2010
- Author(s)
  Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T.
- Journal Title
  
  J Clin Invest.
  
  Volume: 120 Pages: 2370-2378
- NAID
  130004505744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591244
[Presentation] B7H1 expression on recipient regulate the frequency of IL-17+ IFNg+ T cells and contribute to the pathogenesis of cGVHD.2013
- Author(s)
  H Fujiwara, K Kobayashi, H Nishimori, M Nishinohara, S Okamoto, K Matsuoka, E Kondo, N Fujii, K Shinagawa, M Tanimoto and Y Maeda.
- Organizer
  ASBMT tandem meeting
- Place of Presentation
  Solt lake cuty, USA
- Data Source
  KAKENHI-PROJECT-24591425
[Presentation] Donor Th17 and Th1 Contribute to Chronic Graft-Versus-Host Disease2010
- Author(s)
  H Nishimori, R Sugiyama, K Kobayashi, Y Yamasuji, S Kadohisa, K Takeuchi, Y Iwakura, M Tanimoto, Y Maeda
- Organizer
  アメリカ血液学会
- Place of Presentation
  フロリダ
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21591244
[Presentation] Breast-feeding mediates feto-matemal tolerance and improves outcome of allogeneic bone marrow transplantation.2007
- Author(s)
  Aoyama K, Matsuoka K, Hashimoto D, Ichinohe T, Harada M, Tanimoto M, Teshima T
- Organizer
  49^<th> Annual Meeting of The American Society of Hematology
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-17390280
[Presentation] Host plasmacytoid or conventional dendritic cells alone are sufficient to initiate graft-versus-host disease2007
- Author(s)
  M., Koyama, D., Hashimoto, K., Aoyama, K., Matsuoka, K., Karube, K., Takeda, K., Ohshima, M., Tanimoto, M., Harada, T., Teshima
- Organizer
  49th Annual Meeting of ASH
- Place of Presentation
  Atlanta, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390280
[Presentation] Host plasmacytoid or conventional dendritic cells alone are sufficient to initiate graft-versus-host disease.2007
- Author(s)
  Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K, Takeda K, Ohshima K, Tanimoto M, Harada M, Teshima T
- Organizer
  49^<th> Annual Meeting of The American Society of Hematology
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-17390280

1. SAITO Hidehiko (20153819)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. 唐渡雅行

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. MAEDA Yoshinobu (60403474)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
4. TAKAMATSU Junki (80221365)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KOJIMA Tetsuhito (40161913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. EMI Nobuhiko (30185144)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KOUNO Akio

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 都築忍

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NAOE Tomoki (50217634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIMARU Fumihiko (50284097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TESHIMA Takanori (40284096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 浜口道成 (90135351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松岡賢市 (90432640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. TAKEO Takaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IIJIMA Narikazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 横澤敏也

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 松岡明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TANIMOTO Mitsune 谷本 光音

TANIMOTO Mistune 谷本 光音

Research Projects

Research Products

Co-Researchers

Low-dose IL-2 therapy to maintain Treg homeostasis under the use of calcineurin inhibitorPrincipal Investigator

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The role of PD1 pathway on tolerance after allogeneic transplantationPrincipal Investigator

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細胞障害性Tリンパ球を模した細胞障害性ゼラチンビーズの開発Principal Investigator

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Gene Therapy Using rAAV Vector Against Hematological Disorders : From Basic Science To Clinical Application.Principal Investigator

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TANIMOTO Mitsune 谷本光音

TANIMOTO Mistune 谷本光音