NAOE Tomoki 直江知樹

Researcher Number	50217634
Other IDs
Affiliation (Current)	2022: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 院長
Affiliation (based on the past Project Information) *help	2014 – 2015: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, 院長 2013 – 2014: 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 2013: 名古屋医療センター, 血液内科, 院長 2011 – 2012: 名古屋大学, 医学(系)研究科(研究院), 教授 2011 – 2012: 名古屋大学, 医学系研究科, 教授 … More 2007 – 2010: Nagoya University, 大学院・医学系研究科, 教授 2005 – 2006: 名古屋大学, 大学院医学系研究科, 教授 2002 – 2005: Nagoya University, Graduate school of Medicine Professor, 大学院・医学系研究科, 教授 2001: Graduate School of medicinej, Nagoya University Professor, 大学院・医学研究科, 教授 1994 – 2000: 名古屋大学, 医学部, 助教授 1992 – 1993: 名古屋大学, 医学部, 講師 1989 – 1991: 名古屋大学, 医学部, 助手 1986: Nagoya University school of medicine Fellow, 医学部, 医員 Less
Review Section/Research Field	Principal Investigator Hematology / Hematology / Biological Sciences / 老化(加齢) Except Principal Investigator Hematology / Hematology / Biological Sciences / Pediatrics
Keywords	Principal Investigator FLT3 / 白血病 / 急性前骨髄球性白血病 / シグナル伝達 / leukemia / 分子標的治療 / キナーゼ阻害剤 / 急性リンパ性白血病 / 治療関連二次性白血病 / 染色体転座 … More / チロシンキナーゼ / アポトーシス / 分子標的療法 / 免疫不全マウス / 幹細胞 / 耐性 / 癌 / トランスレーショナルリサーチ / caspase 8 / JAK2 / JAK3 / 微量残存腫瘍 / 遺伝子マーカー / 免疫グログリン / 超可変部遺伝子 / PCR / 治療効果 / 免疫グロブリン重鎖(IgH)遺伝子 / 加齢 / B細胞レパトアー / CDR-III / B細胞分化 / 抗体サブクラス / mutation / 残存腫瘍 / 転座メカニズム / tandem duplication / PML-RARalfa / kinase inhibitor / histone deacetylase / TEL / トランスインフォメーション / 遺伝子変異 / メチル化 / キメラ転写因子 / STAT / マウスモデル / 急性前骨髓球性白血病 / PML-RARα / 転写抑制複合体 / キメラ転写物 / 転写抑制 / 治療法 / 化学療法 / 造血ニッチ / 接着 / ホーミング / ニッシェ / 残存 / がん薬物治療 / STAT3 / STAT5 / FLT３ / FLT3阻害剤 / 分子標的剤 / STAT3/5阻害剤 / pyruvinium pamoate / 中鎖脂肪酸誘導体 / 薬剤スクリーニング / 微小環境 / 悪性リンパ腫 / PDX / 酸化ストレス / 標準治療 / 白血球 / As_2O_3 / As_< 2> O_< 3> / caspase-8 / 急性前骨髄性白血病 / 亜ヒ素酸 / レドックス / apoptosis / AsィイD22ィエD2OィイD23ィエD2 / トランスジェニックマウス / 骨髄移植モデル / 変異FLT3 / Leukemia / transgenic mouse / Molecularly targeted thrapy / 標的治療 / サロゲートマーカー / 造血器腫瘍 / ヌクレオフォスミン / 変異 / 発現クローニング法 / cell signaling / target therapy / surrogate marker … More Except Principal Investigator FLT3 / レチノイン酸 / 分化誘導療法 / 急性前骨髄球性白血病 / Am-80 / 白血病 / PML / 急性白血病 / チロシンキナーゼ / leukemia / 急性リンパ性白血病 / RAR遺伝子 / PML遺伝子 / 分子生物学 / 細胞内レチノイン酸結合蛋白 / レチノイドアンタゴニスト / 分子標的療法 / ケモカイン / MDR1 / 造血幹細胞 / all-trans retinoic acid / As_2O_3 / アポトーシス / acute promyelocytic leukemia / JALSG / matched-pair analysis / GVL / SEREX / CEV / SYK / tandem duplication / JMML / BMI-1 / PI3K / cALL / 免疫グロブリン遺伝子 / 微量残存腫瘍 / CDR3 / 分子マ-カ- / レチノイン酸受容体 / 急性前骨髄性白血病 / 分子誘導療法 / レチノイド / レチノイン酸レセプター / ポリプレン酸 / ブファリン / ユビキチン・プロテアゾーム / トランスジェニック・マウス / RARA / 亜砒酸 / 抗体療法 / 前臨床試験 / ガングリオシド / 抗体リモデリング / 肝炎ウイルス / MUM1 / 抗体 / translation research / ハイリスクgenotype / ガングリオシドGD2抗体 / IRF4 / 抗変異EGFレセプター抗体(3C10) / ヒト化抗体 / ケモカインCCR4 / リモデリング / 抗ガングリオシド抗体 / FLT3遺伝子 / 抗ケモカインレセプター抗体 / ウィルス発癌 / 抗c-kit / CEA / CD25抗体 / ガングリオシドGD2 / ヒストンデアセチラーゼ(HDAC) / FK228 / 血液腫瘍学 / 血液悪性腫瘍幹細胞 / ニッチェ / 血液学 / 腫瘍微小環境 / 白血病ニッチェ / 遺伝子導入 / 多剤耐性遺伝子 / Pー糖蛋白 / レトロウイルスベクタ- / 薬剤耐性 / 形貭転換 / 形質転換 / mdr / 骨髄幹細胞 / CFU / PSVLベクタ- / Gene transfection / Multidrug resistant gene / P-glycoprotin / Hematopoietic stem cells / Retroviral vector / Drug resistance / Phenotypic change / PML-RARαキメラ遺伝子 / 癌瘍1号-713 / Vitamin A / apoptosis / retinoid / cytoplasmic retinoic acid binding protein / 化学療法 / 骨髄移植療法 / マッチドペアアナリシス / メタアナリシス / 急性骨髄性白血病 / メタアナリス / IBMTR / MRC / acute leukemia / chemotherapy / bone marrow transplantation / differentiation therapy / meta-analysis / ワクチン / 遺伝子銃 / DNAワクチン / PDGFR / チロシンリン酸化 / マンノース / デンドリマー / DC / SFV / Vaccine / Gene Gun / DNA Vaccine / trandem duplication / 点突然変異 / point mutation / Tyrosine kinase / 遺伝子変異 / tyrosinekinase / molecular target therapy / genetic mutation / NOGマウス / 再生不良性貧血 / T細胞 / 7モノソミー / G-CSF / NOG mice / Aplastic Anemia / T cell / 分化 / 増殖 / マウス移植モデル / Differentiation / Proliferation / Apoptosis / Mouse model / インテグリン / 細胞接着 / 細胞外マトリックス / P13K / PI3キナーゼ / JNK / integrin / tyrosine kinase / cell adhesion / extracellular matrix / 血小板 / 血小板膜蛋白分子 / GP【II】b / 【III】a / モノクローナル抗体 / 血小板異常症 / アミノ酸配列 / Platelets / Platelet membrane molecules / GPIIb-IIIa / Platelet abnormality Less

Translational research toward drug discovery of leukemiaPrincipal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Hospital Organization Nagoya Medical Center
Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cellsPrincipal Investigator
- Principal Investigator
  
  NAOE TOMOKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  National Hospital Organization Nagoya Medical Center
Effects of FGF2 on the leukemia microenvironment in the bone marrow
- Principal Investigator
  
  NAKAYAMA Takayuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Medical University
  Nagoya University
Development of innovative anti-tumor agents that target signal transducers and activator of transcriptionPrincipal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Basic research aimed at understanding and overcoming of the primary and secondary resistance in molecular target therapyPrincipal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Molecular mechanisms and therapeutic approach of residual leukemiaPrincipal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Research & Development of molecular target therapy for leukemia and Its assessment SystemPrincipal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Crosstalk of FLT3 and integrin signal transduction pathway in acute myeloid leukemia
- Principal Investigator
  
  KATSUMI Akira
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Analysis of aberrant signal tansduction in hematological malignancy and development of treatment methods.Principal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Role of BMI-1 in leukemia
- Principal Investigator
  
  YAMAMOTO Kauzhito
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center
  Nagoya University
Effect of G-CSF on hematopoietic stem cells derived from aplastic anemia patients in NOD/SCID/γc^<null> mice
- Principal Investigator
  
  KOJIMA Seiji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Nagoya University
白血病に選択性を有する分子標的治療法ならびにその評価法の開発Principal Investigator
- Principal Investigator
  
  直江知樹
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Basic investigation for the development of a novel anti-leukemic therapy targeting to the mutant FLT3 molecule.
- Principal Investigator
  
  KIYOI Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Establishment of a leukemia model mouse by introducing mutated FLT3 genePrincipal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
抗体療法及びがんの前臨床試験研究
- Principal Investigator
  
  上田龍三
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
Analysis of the deregulation mechanism on cell growth and differentiation induced by mutant ELT3
- Principal Investigator
  
  KIYOI Hitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Novel immunotherapy for Hematological Malignancy
- Principal Investigator
  
  SAITO Hidehiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
白血病進展に関与する異常FLT3分子の標的分子群の解析Principal Investigator
- Principal Investigator
  
  直江知樹
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
Involvement of Fas ligand-independent caspase8 activation in AsィイD22ィエD2OィイD23ィエD2-induced apoptosisPrincipal Investigator
- Principal Investigator
  
  NAOE Tomoki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
白血病に関わる染色体転座部位の構造解析による転座メカニズム研究Principal Investigator
- Principal Investigator
  
  直江知樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Collaborative study for the best treatment of acute leukemia.
- Principal Investigator
  
  OHNO Ryuzo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Hematology
- Research Institution
  Hamamatsu University School of Medicine
がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
治療関連二次性白血病の発症にかかわる染色体転座機構の研究Principal Investigator
- Principal Investigator
  
  直江知樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
マルチパラメーターによる微量残存白血病の同定とその臨床意義の検討Principal Investigator
- Principal Investigator
  
  直江知樹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
加齢にともなうB細胞免疫グロブリン遺伝子レパトアーの変遷Principal Investigator
- Principal Investigator
  
  直江知樹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Nagoya University
Differentiation therapy of acute promylocytic leukemia.
- Principal Investigator
  
  OHNO Ryuzo, 大野龍三
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Hamamatsu Univ.
遺伝子マーカーを指標にした微量残存腫瘍の高感度検出と治療効果の新評価法Principal Investigator
- Principal Investigator
  
  直江知樹
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
レチノイン酸による白血病の分化誘導療法と分化機構の分子生物学的解明
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
免疫遺伝子超可変部をマ-カとした2ステップPCR法による微量残存腫瘍の検出
- Principal Investigator
  
  OHNO Ryuzo
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
Transfection of Multidrug Resistant Gene into Human Hematopoietic Stem Cells and its Clinical Application in Bone Marrow Transplantation
- Principal Investigator
  
  OHNO Ryuzo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagoya University
Molecular analysis of platelet membrane protein abnormality
- Principal Investigator
  
  SHIKU Hiroshi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Nagasaki University

[Book] 造血器腫瘍取り扱い規約2010
- Author(s)
  直江知樹, 他
- Publisher
  金原出版
- Data Source
  KAKENHI-PROJECT-22390192
[Book] 造血器腫瘍取り扱い規約2010
- Author(s)
  直江知樹他
- Total Pages
  265
- Publisher
  金原出版
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia2016
- Author(s)
  Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Pages: 4723-31
- DOI
  10.1074/jbc.m115.637835
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09492, KAKENHI-PROJECT-25293218
[Journal Article] Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells.2016
- Author(s)
  Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T
- Journal Title
  
  Leukemia and lymphoma
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells.2016
- Author(s)
  Shinohara H, Kumazaki M, Minami Y, Ito Y, Sugito N, Kuranaga Y, Taniguchi K, Yamada N, Otsuki Y, Naoe T, Akao Y
- Journal Title
  
  Cancer Lett.
  
  Volume: 371 Pages: 1-11
- DOI
  10.1016/j.canlet.2015.11.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293218, KAKENHI-PROJECT-16K10482
[Journal Article] Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells.2015
- Author(s)
  Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T
- Journal Title
  
  Sci Rep
  
  Volume: 5 Pages: 1-12
- DOI
  10.1038/srep13054
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09473, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-25670101, KAKENHI-PROJECT-25293218
[Journal Article] Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells.2015
- Author(s)
  Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M
- Journal Title
  
  J Immunol
  
  Volume: 194(3) Pages: 911-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670449
[Journal Article] Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia.2015
- Author(s)
  Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y.
- Journal Title
  
  Cancer Letter
  
  Volume: 360 Pages: 28-38
- DOI
  10.1016/j.canlet.2015.01.039
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25118711, KAKENHI-PROJECT-25293218, KAKENHI-PROJECT-25461412, KAKENHI-PROJECT-25462003
[Journal Article] Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells.2015
- Author(s)
  Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M
- Journal Title
  
  J Immunol
  
  Volume: 194(3) Pages: 911-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients2014
- Author(s)
  Kihara R, S. Ogawa, S. (32/33) Naoe, T.
- Journal Title
  
  Leukemia
  
  Volume: inpress Pages: 1-10
- DOI
  10.1038/leu.2014.55
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22134006, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-24590688, KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-25293218, KAKENHI-PROJECT-26461431
[Journal Article] Dexamethasone Palmitate Ameliorates Macrophages-Rich Graft-versus-Host Disease by Inhibiting Macrophage Functions2014
- Author(s)
  Satoshi Nishiwaki, Takayuki Nakayama, Makoto Murata, Tetsuya Nishida, Seitaro Terakura, Shigeki Saito, Tomonori Kato, Hiroki Mizuno, Nobuhiko Imahashi, Aika Seto, Yukiyasu Ozawa, Koichi Miyamura, Masafumi Ito, Kyosuke Takeshita, Hidefumi Kato, Shinya Toyokuni, Keisuke Nagao, Ryuzo Ueda, and Tomoki Naoe
- Journal Title
  
  PLoS ONE
  
  Volume: 9(5)
- DOI
  10.1371/journal.pone.0096252
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23591382, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-24790969, KAKENHI-PROJECT-26461435
[Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014
- Author(s)
  Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).
- Journal Title
  
  Blood Cancer J
  
  Volume: 4
- NAID
  120006987091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group.2014
- Author(s)
  Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).
- Journal Title
  
  Blood Cancer J
  
  Volume: 4
- NAID
  120006987091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670449
[Journal Article] Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.2014
- Author(s)
  Hayakawa F, Tomita A, Naoe T
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 55(4) Pages: 445-449
- NAID
  130004920671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome.2014
- Author(s)
  Hayakawa F, Tomita A, Naoe T
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 55（4） Pages: 445-449
- NAID
  130004920671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670449
[Journal Article] Epigenetic regulation of microRNA-128a expression contributes to the apoptosis-resistance of human T-cell leukaemia Jurkat cells by modulating the expression of Fas-associated protein with death domain (FADD).2014
- Author(s)
  Yamada N, Noguchi S, Kumazaki M, Shinohara H, Miki K, Naoe T, Akao Y.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1843(3) Pages: 590-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293218
[Journal Article] De novo DLBCL with a CD20 IHC(+) and FCM(-) phenotype: molecular mechanisms and correlation with rituximab sensitivity.2014
- Author(s)
  Tokunaga T, Tomita A, Sugimoto K, Shimada K, Iriyama C, Hirose T, Shirahata-Adachi M, Suzuki Y, Mizuno H, Kiyoi H, Asano N, Nakamura S, Kinoshita T, Naoe T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Pages: 35-43
- DOI
  10.1111/cas.12307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-24591388, KAKENHI-PROJECT-25670449
[Journal Article] A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STATaddictive oncokinases2013
- Author(s)
  Fumihiko Hayakawa, Keiki Sugimoto, Yasuo Harada, Norikazu Hashimoto, Naoto Ohi, Shingo Kurahashi, Tomoki Naoe
- Journal Title
  
  Blood Cancer J
  
  Volume: 3
- DOI
  10.1038/bcj.2013.63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381, KAKENHI-PUBLICLY-25118711, KAKENHI-PROJECT-25293218
[Journal Article] Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.2013
- Author(s)
  Kiyoko Yamamoto, Shinobu Tsuzuki, Yosuke Minami, Yukiya Yamamoto, Akihiro Abe, Koichi Ohshima, Masao Seto, Tomoki Naoe.
- Journal Title
  
  PLoS One.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0074864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591410, KAKENHI-PROJECT-24390249, KAKENHI-PROJECT-25461412, KAKENHI-PROJECT-25461437, KAKENHI-PROJECT-25670449
[Journal Article] Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells.2013
- Author(s)
  Yamada N., Noguchi S., Mor i T., Naoe T., Maruo K. and Akao Y.
- Journal Title
  
  Cancer Lett
  
  Volume: 335 Pages: 332-342
- DOI
  10.1016/j.canlet.2013.02.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J00639, KAKENHI-PROJECT-25293218
[Journal Article] J Biol2013
- Author(s)
  Ando K
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 9457-9467
- DOI
  10.1074/jbc.m112.415703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591040, KAKENHI-PROJECT-22591065, KAKENHI-PROJECT-23590829, KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-25293218
[Journal Article] Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia.2013
- Author(s)
  Katagiri S, Minami Y, Naoe T, et al.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 19 Pages: 1422-1432
- DOI
  10.1158/1078-0432.ccr-12-1777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-23501312, KAKENHI-PROJECT-24390244, KAKENHI-PROJECT-24659461, KAKENHI-PUBLICLY-25112706, KAKENHI-PROJECT-25461412, KAKENHI-PUBLICLY-23112507
[Journal Article] Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome.2012
- Author(s)
  Iriyama C, Tomita A, Hoshino H,Adachi-Shirahata M, Furukawa-Hibi Y, Yamada K, Kiyoi H, Naoe T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Pages: 662-669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation.2012
- Author(s)
  Yasuda T, Hayakawa F, Kurahashi S, Sugimoto K, Minami Y, Tomita A, Naoe T.
- Journal Title
  
  J Immunol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] B Cell Receptor-ERK1/2 Signal Cancels PAX5-Dependent Repression of BLIMP1 through PAX5 Phosphorylation: A Mechanism of Antigen-Triggering Plasma Cell Differentiation.2012
- Author(s)
  Takahiko Yasuda, Fumihiko Hayakawa, Shingo Kurahashi, Keiki Sugimoto , Yosuke Minami, Akihiro Tomita, Tomoki Naoe
- Journal Title
  
  Exp Hematol.
  
  Volume: 188 Pages: 6127-34
- DOI
  10.4049/jimmunol.1103039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591381, KAKENHI-PROJECT-23659487, KAKENHI-PROJECT-24591388
[Journal Article] Retrospective analysis of prognostic factors for angioimmunoblastic T-cell lymphoma: a multicenter cooperative study in Japan2012
- Author(s)
  Tokunaga T, Shi mada K, Yamamoto K, Chihara D, Ichihashi T, Oshima R, Tanimoto M, Iwasaki T, Isoda A, Sakai A, Kobayashi H, Kitamura K, Matsue K, Taniwaki M, Tamashima S, Saburi Y, Masunari T, Naoe T, Nakamura S, Kinoshita T
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 2837-2843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation: macrophage-targeted steroid therapy.2012
- Author(s)
  西脇聡史
- Journal Title
  
  Int J Hematol
  
  Volume: (Epub ahead of print) Pages: 428-33
- DOI
  10.1007/s12185-012-1023-z
- NAID
  10030632677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04711, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23591415
[Journal Article] CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-7372012
- Author(s)
  Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T
- Journal Title
  
  Exp Hematol
  
  Volume: 40 Pages: 724-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Retention of CD34(+) CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.2012
- Author(s)
  Minami Y, Abe A, Minami M, Kitamura K, Hiraga J, Mizuno S, Yamamoto K, Sawa M, Inagaki Y, Miyamura K, Naoe T.
- Journal Title
  
  Leukemia
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib2012
- Author(s)
  Mizuno H, Nakayama T, Miyata Y, Saito S, Nishiwaki S, Nakao N, Takeshita K, Naoe T
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2269-2276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-7372012
- Author(s)
  Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T.
- Journal Title
  
  Exp Hematol
  
  Volume: 40 Pages: 724-737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Retention of CD34(+) CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.2012
- Author(s)
  Minami Y, Abe A, Minami M, Kitamura K, Hiraga J, Mizuno S, Ymamoto K, Sawa M, Inagaki Y, Miyamura K, Naoe T
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2142-2143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Retention of CD34(+) CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.2012
- Author(s)
  Minami Y, Abe A, Minami M, Kitamura K, Hiraga J, Mizuno S, Ymamoto K, Sawa M, Inagaki Y, Miyamura K, Naoe T.
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2142-2143
- DOI
  10.1038/leu.2012.73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Y654 of β-catenin is essential for FLT3/ITD-related twosine phosphorylation and nuclear localization of β-catenin2012
- Author(s)
  Tomohiro Kajiguchi
- Journal Title
  
  Eur J Haematol.
  
  Volume: (in press) Pages: 314-320
- DOI
  10.1111/j.1600-0609.2011.01738.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591198, KAKENHI-PROJECT-21591199, KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-24591387, KAKENHI-PROJECT-24591416
[Journal Article] B Cell Receptor-ERK1/2 Signal Cancels PAX5-Dependent Repression of BLIMP1 through PAX5 Phosphorylation: A Mechanism of Antigen-Triggering Plasma Cell Differentiation2012
- Author(s)
  Yasuda T, Hayakawa F, Kurahashi S, Sugimoto K, Minami Y, Tomita A, Naoe T.
- Journal Title
  
  J Immunol.
  
  Volume: 188 Pages: 6127-6134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin.2012
- Author(s)
  Kajiguchi T, Katsumi A, Tanizaki R, Kiyoi H, Naoe T
- Journal Title
  
  Eur J Haematol
  
  Volume: 88 Pages: 314-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737.2012
- Author(s)
  Shimada K, Tomita A, Minami Y, Kiyoi H, Naoe T et al.
- Journal Title
  
  Exp Hematol
  
  Volume: 40 Pages: 724-737
- DOI
  10.1016/j.exphem.2012.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-23659487, KAKENHI-PROJECT-24591387
[Journal Article] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib.2012
- Author(s)
  水野　紘樹
- Journal Title
  
  Leukemia.
  
  Volume: 26 Pages: 2269-2269
- DOI
  10.1038/leu.2012.81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790907, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23659487
[Journal Article] B Cell Receptor-ERK1/2 Signal Cancels PAX5-Dependent Repression of BLIMP1 through PAX5 Phosphorylation: A Mechanism of Antigen-Triggering Plasma Cell Differentiation.2012
- Author(s)
  Yasuda T, Hayakawa F, Kurahashi S, Sugimoto K, Minami Y, Tomita A, Naoe T.
- Journal Title
  
  J Immunol
  
  Volume: 188 Pages: 6127-6134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis2012
- Author(s)
  Nishiwaki S
- Journal Title
  
  International Journal of Hematology
  
  Volume: 96(3) Pages: 295-300
- DOI
  10.1007/s12185-012-1140-8
- NAID
  10031121256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590887, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23591415
[Journal Article] Mesenchymal stem cells stably transduced with a dominant negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage2011
- Author(s)
  斎藤繁紀
- Journal Title
  
  Am J Pathol.
  
  Volume: 179 Pages: 1088-1094
- DOI
  10.1016/j.ajpath.2011.05.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04711, KAKENHI-PROJECT-23591382, KAKENHI-PROJECT-23659431
[Journal Article] Treatment with mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011
- Author(s)
  Kuwatsuka Y, Naoe T, et al
- Journal Title
  
  Blood Cancer J
  
  Volume: 1 Pages: 1-7
- DOI
  10.1038/bcj.2011.16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-22790908, KAKENHI-PROJECT-23591381
[Journal Article] Japan Adult Leukemia Study Group. BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.2011
- Author(s)
  Ono T, Miyawaki S, Kimura F, Kanamori H, Ohtake S, Kitamura K, Fujita H, Sugiura I, Usuki K, Emi N, Tamaki S, Aoyama Y, Kaya H, Naoe T, Tadokoro K, Yamaguchi T, Ohno R, Ohnishi K
- Journal Title
  
  Leuk Res
  
  Volume: 35 Pages: 598-603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Mesenchymal stem cells stably transduced with a dominant negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage.2011
- Author(s)
  Saito S, Nakayama T*, Hashimoto N, Miyata Y, Egashira K, Nakao N, Nishiwaki S, Hasegawa M, Hasegawa Y, Naoe T
- Journal Title
  
  Am J Pathol.
  
  Volume: 179 Pages: 1088-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591382
[Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML. Oncogene2011
- Author(s)
  Kurahashi S, Naoe T, et al
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 1822-1830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment.2011
- Author(s)
  Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 1600-1609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment2011
- Author(s)
  Goto E, Naoe T, et al
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 1600-1609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] The mTOR inhibitor, everolimus (RAD001), overcomes resistanceto imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011
- Author(s)
  Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T
- Journal Title
  
  Blood Cancer J
  
  Volume: 1(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis2011
- Author(s)
  Sakai K, Ishikawa Y, Mori Y, Kobayashi M, Iriyama C, Ozawa Y, Suzuki T, Minami Y,Ishikawa K, Kaneda N, Naoe T, Kiyoi H
- Journal Title
  
  Int J Hematol
  
  Volume: 93 Pages: 237-242
- NAID
  10029533322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML2011
- Author(s)
  Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 1822-1830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment2011
- Author(s)
  Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 1600-1609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML2011
- Author(s)
  Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 1822-1830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Japan Adult Leukemia Study Group. BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay2011
- Author(s)
  Ono T, Naoe T, et al
- Journal Title
  
  Leuk Res
  
  Volume: 35 Pages: 598-603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.2011
- Author(s)
  Ono T, Naoe T, et al.
- Journal Title
  
  Leuk Res.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] The mTOR inhibitor, everolimus (RAD001), overcomes resistanceto imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011
- Author(s)
  Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T.
- Journal Title
  
  Blood Cancer J
  
  Volume: 1(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML.2011
- Author(s)
  Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T.
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 1822-1830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] AX5-PML acts as a dual dominant-negative form of both PAX 5 and PML.2011
- Author(s)
  Kurahashi S, Naoe T, et al.
- Journal Title
  
  Oncogene
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment2010
- Author(s)
  Minami Y, Kajiguchi T, Abe A, Ohno T, Kiyoi H, Naoe T
- Journal Title
  
  Int J Hematol
  
  Volume: 92 Pages: 664-666
- NAID
  10027674164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study.2010
- Author(s)
  Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 2186-2192
- NAID
  10027832450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB42010
- Author(s)
  Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T
- Journal Title
  
  Eur J Haematol 84
  
  Pages: 229-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB42010
- Author(s)
  Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T
- Journal Title
  
  Eur J Haematol 84
  
  Pages: 229-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia2010
- Author(s)
  Tsujimura A, Kiyoi H, Shiotsu Y, Ishikawa Y, Mori Y, Ishida H, Toki T, Ito E, Naoe T
- Journal Title
  
  Int J Hematol
  
  Volume: 92 Pages: 624-633
- NAID
  10027673999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659487
[Journal Article] Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia : a renort from the BINGO study.2010
- Author(s)
  Ishikawa Y, Naoe T, et al.
- Journal Title
  
  Cancer Sci.
  
  Volume: 101 Pages: 2186-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192
[Journal Article] KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation2009
- Author(s)
  Shiotsu Y, Kiyoi H, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T.
- Journal Title
  
  Blood. 114
  
  Pages: 1607-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Circumventing resistance to imatinib therapy in chronic myeloid leukemia2009
- Author(s)
  Minami Y, Naoe T
- Journal Title
  
  Gan To Kagaku Ryoho 36(4)
  
  Pages: 544-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] rrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD/SCID/IL-2R gammac mice2009
- Author(s)
  Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T
- Journal Title
  
  Cancer Sci (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] GATA-1 and GATA-2 binding to 3' enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines2009
- Author(s)
  Furuhata A, Murakami M, Ito H, Gao S, Yoshida K, Sobue S, Kikuchi R, Iwasaki T, Takagi A, Kojima T, Suzuki M, Abe A, Naoe T, Murate T.
- Journal Title
  
  Leukemia. 23
  
  Pages: 1270-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] GATA-1 and GATA-2 binding to 3'enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines.2009
- Author(s)
  Furuhata A, Naoe T, et al
- Journal Title
  
  Leukemia. 12(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia2009
- Author(s)
  Ishikawa Y, Kiyoi H, Tsujimura A, Miyawaki S, Miyazaki Y, Kuriyama K, Tomonaga M, Naoe T.
- Journal Title
  
  Eur J Haematol 83
  
  Pages: 90-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation2009
- Author(s)
  Shiotsu Y, Kiyoi H, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T
- Journal Title
  
  Blood 114
  
  Pages: 1607-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy2008
- Author(s)
  Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T
- Journal Title
  
  Int J Hematol 88
  
  Pages: 471-5
- NAID
  10023971017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Prognostic implication and biological roles of RhoH in acute myeloid leukaemia2008
- Author(s)
  Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T
- Journal Title
  
  Eur J Haematol 81
  
  Pages: 454-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] BCR-ABL-transformed GMP as myeloid leukemic stem cells2008
- Author(s)
  Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang JY
- Journal Title
  
  Proc Natl Acad Sci U S A 105
  
  Pages: 17967-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome2008
- Author(s)
  Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T.
- Journal Title
  
  Br J Haematol. 140
  
  Pages: 394-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] BCR-ABL-transformed GMP as myeloid leukemic stem cells2008
- Author(s)
  Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang JY.
- Journal Title
  
  Proc Natl Acad Sci U S A 105
  
  Pages: 17967-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Abnormal cytoplasmic dyslocalisation and/or reduction of nucle ophosmin protein level rarely occurs in myelodysplastic syndromes.2008
- Author(s)
  Ishikawa Y, Naoe T, et al
- Journal Title
  
  Leuk Lymphoma. 49
  
  Pages: 2359-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis2008
- Author(s)
  Hayakawa F, Naoe T, et.al.
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 24420-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy.2008
- Author(s)
  Abe A, Naoe T, et al
- Journal Title
  
  Int J Hematol. 88
  
  Pages: 471-5
- NAID
  10023971017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy2008
- Author(s)
  Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.
- Journal Title
  
  Int J Hematol. 88
  
  Pages: 471-5
- NAID
  10023971017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Prognostic implication and biological roles of RhoH in acute myeloid leukaemia2008
- Author(s)
  Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T.
- Journal Title
  
  Eur J Haematol 81
  
  Pages: 454-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] BCR-ABL-transformed GMP as myeloid leukemic stem cells2008
- Author(s)
  Minami Y and Naoe T, et.al.
- Journal Title
  
  Proc Natl Acad Sci USA. 105
  
  Pages: 17967-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors2008
- Author(s)
  Ishida H and Naoe T, et.al.
- Journal Title
  
  Bioorg Med Chem Lett. 18
  
  Pages: 5472-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Mutational analysis of SOS1 gene in acute myeloid leukemia2008
- Author(s)
  Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T
- Journal Title
  
  Int J Hematol 88
  
  Pages: 460-2
- NAID
  10023970986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)2007
- Author(s)
  Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T
- Journal Title
  
  Eur J Haematol 79
  
  Pages: 25-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD2007
- Author(s)
  Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T.
- Journal Title
  
  Leukemia 21
  
  Pages: 403-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice2007
- Author(s)
  Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T
- Journal Title
  
  Leukemia 21
  
  Pages: 136-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390261
[Journal Article] LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)2007
- Author(s)
  Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.
- Journal Title
  
  Eur J Haematol. 79
  
  Pages: 25-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU. 1-induced C/EBPepsilon expression in myeloid differentiation2007
- Author(s)
  Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 5819-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults2007
- Author(s)
  Kiyoi H, Yamaji S, Kojima S, Naoe T.
- Journal Title
  
  Leukemia 21
  
  Pages: 574-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells2007
- Author(s)
  Kajiguchi T, Chung EJ, Lee S, Stine A, Kiyoi H, Naoe T, Levis MJ, Neckers L, Trepel JB.
- Journal Title
  
  Leukemia 21
  
  Pages: 2476-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.2007
- Author(s)
  Ninomiya M, Abe A, Katsumi A. Naoe T et al.
- Journal Title
  
  Leukemia. 21(1)
  
  Pages: 136-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590989
[Journal Article] Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice2007
- Author(s)
  Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.
- Journal Title
  
  Leukemia 21
  
  Pages: 136-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations2007
- Author(s)
  Kiyoi H, Shiotsu Y, Ozeki K, Yamaji S, Kosugi H, Umehara H, Shimizu M, Arai H, Ishii K, Akinaga S, Naoe T.
- Journal Title
  
  Clin Cancer Res. 13(15Pt1)
  
  Pages: 4575-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication2006
- Author(s)
  Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T.
- Journal Title
  
  Int J Hematol 84
  
  Pages: 328-36
- NAID
  10019259671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation.2006
- Author(s)
  Adachi T, Matsushita T, Ichihashi R, Hirashima K, Ito M, Inukai A, Yokozawa T, Nishida T, Murata M, Hayashi M, Katsumi A. Kojima T, Saito H, Naoe T.
- Journal Title
  
  Int J Hematol. 83(5)
  
  Pages: 415-9
- NAID
  10018141145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590989
[Journal Article] Japan Adult Leukemia Study Group. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: a phase II study by the Japan Adult Leukemia Study Group2006
- Author(s)
  Yanada M, Takeuchi J, Sugiura I, Akiyama H, Usui N, Yagasaki F, Kobayashi T, Ueda Y, Takeuchi M, Miyawaki S, Maruta A, Emi N, Miyazaki Y, Ohtake S, Jinnai I, Matsuo K, Naoe T, Ohno R
- Journal Title
  
  J Clin Oncol. 24
  
  Pages: 460-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Recurrent intramural hematoma of small intestine in a severe hemophilia A patient with high titer of factor VIII inhibitor. A case report and a review of the literatures.2006
- Author(s)
  Katsumi A Matsushita T, Hiroshima K, Iwasaki T, Adachi T, Yamamoto K, Kojima T, Takamatsu J, Saito H, Naoe T.
- Journal Title
  
  Int J.Hematol. 84(2)
  
  Pages: 166-9
- NAID
  10019284929
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590989
[Journal Article] Establishment of Stroma Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2 with FLT3 Tandem Duplication.2006
- Author(s)
  Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A. Emi N, Naoe T.
- Journal Title
  
  Int J.Hematol. 84(4)
  
  Pages: 328-36
- NAID
  10019259671
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590989
[Journal Article] Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo2006
- Author(s)
  Atsumi A, Tomita A, Kiyoi H, Naoe T.
- Journal Title
  
  Biochem Biophys Res Commun. 345
  
  Pages: 1471-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice. _2006
- Author(s)
  Hayashi M, Matsushita T, Mackman N, Ito M, Adachi T, Katsumi A, Yamamoto K, Takeshita K, Kojima T, Saito H, Murohara T, Naoe T.
- Journal Title
  
  J Thromb Haemost. 4(1)
  
  Pages: 177-85
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590989
[Journal Article] PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia2006
- Author(s)
  Yamamoto T, Isomura M, Xu Y, Liang J, Yagasaki H, Kamachi Y, Kudo K, Kiyoi H, Naoe T, Kojma S.
- Journal Title
  
  Leuk Res. 30
  
  Pages: 1085-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation2006
- Author(s)
  Kiyoi H, Naoe T.
- Journal Title
  
  Int J Hematol 83
  
  Pages: 301-8
- NAID
  10017475435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Identification of amino acid residues essential for heparin binding by the Al domain of human von Willebrand factor.2006
- Author(s)
  Adachi T, Matsushita T, Dong Z, Katsumi A.Nakayama T, Kojima T, Saito H, Sadler JE, Naoe T.
- Journal Title
  
  Biochem Biophys Res Commun. 339(4)
  
  Pages: 1178-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590989
[Journal Article] Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation2006
- Author(s)
  Suzuki M, Abe A, Kiyoi H, Murata M, Ito Y, Shimada K, Morishita Y, Kinoshita T, Naoe T.
- Journal Title
  
  Leukemia 20
  
  Pages: 1168-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] BMI-1 is highly expressed in M0-subtype acute myeloid leukemia.2005
- Author(s)
  Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T.
- Journal Title
  
  Int J Hematol 82
  
  Pages: 42-7
- NAID
  10016602887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Efficacy of gemtuzumab ozogamicin on ATRA- and arsenic-resistant acute promyelocytic leukemia (APL) cells2005
- Author(s)
  Takeshita A, Shinjo K, Naito K, Matsui H, Sahara N, Shigeno K, Horii T, Shirai N, Maekawa M, Ohnishi K, Naoe T, Ohno R.
- Journal Title
  
  Leukemia 19
  
  Pages: 1306-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia2005
- Author(s)
  Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Kinoshita T, Emi N, Naoe T.
- Journal Title
  
  Blood 106
  
  Pages: 2854-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Journal Article] Integrin activation and matrix binding mediate cellar responses to mechanical stretch.2005
- Author(s)
  Katsumi A, Naoe T et al.
- Journal Title
  
  J Biol Chem. 280(17)
  
  Pages: 16546-16549
- Data Source
  KAKENHI-PROJECT-17590989
[Journal Article] Normal and oncogenic FLT32004
- Author(s)
  Naoe T
- Journal Title
  
  Cell Mol Life Sci 61
  
  Pages: 2932-2938
- Data Source
  KAKENHI-PROJECT-14030033
[Journal Article] Normal and oncogenic FLT3.2004
- Author(s)
  Naoe T, et al.
- Journal Title
  
  Cell Mol Life Sci 61(23)
  
  Pages: 2932-2938
- Data Source
  KAKENHI-PROJECT-16390276
[Journal Article] Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD / SCID / IL-2Rgammac mice
- Author(s)
  Tanizaki R, Naoe T., et al.
- Journal Title
  
  Cancer Sci. 2009(in Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016029
[Patent] 細胞を用いたデリバリーシステムの構築2010
- Inventor(s)
  直江知樹, 他
- Industrial Property Rights Holder
  北海道システム/法人岐大/法人名大
- Filing Date
  2010-10-19
- Data Source
  KAKENHI-PROJECT-22390192
[Patent] 急性骨髄性白血病治療剤の候補物質を同定する方法2006
- Inventor(s)
  直江知樹、早川文彦、岡本充功
- Industrial Property Rights Holder
  国立大学法人名古屋大学
- Filing Date
  2006-06-02
- Data Source
  KAKENHI-PROJECT-17016029
[Patent] 急性骨髄性白血病治療剤の候補物質を同定する方法2006
- Inventor(s)
  直江知樹, 早川文彦, 岡本充功
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2006-155281
- Filing Date
  2006-06-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390276
[Patent] 急性骨髄性白血病治療剤の候補物質を同定する方法2006
- Inventor(s)
  直江知樹, 早川文彦, 岡本充功
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Number
  2006-155281
- Filing Date
  2006-06-02
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] TKI非感受性株に対するAIC-47の抗がん作用2015
- Author(s)
  篠原悠、南陽介、熊崎実南、谷口高平、直江知樹、赤尾幸博.
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] 1353 Development of FF-10101, a Novel Irreversible FLT3 Inhibitor, Which Overcomes Drug Resistance Mutations.2015
- Author(s)
  Toshiyuki Nakatani,Ken Uda, Takeshi Yamaura, Masaru Takasaki, Akimi Akashi, Fangli Chen, , Yuichi Ishikawa, Fumihiko Hayakawa, Shinji Hagiwara, Hitoshi Kiyoi, and Tomoki Naoe
- Organizer
  57th ASH Annual Meeting and Exposition
- Place of Presentation
  Orange County Convention Center(米国)
- Year and Date
  2015-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo.2015
- Author(s)
  Takanobu Morishita, Fumihiko Hayakawa, Keiki Sugimoto, Daiki Hirano, Yuki Kojima, Naoto Imoto, Yuichiro Inagaki, Tomoki Naoe and Hitoshi Kiyoi.
- Organizer
  57th ASH Annual Meeting and Exposition
- Place of Presentation
  Orange County Convention Center(米国)
- Year and Date
  2015-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Drug repositioning by patient-derived-xenograft screening for the discovery of new cure for PhALL.2015
- Author(s)
  森下喬允、早川文彦、小島勇貴、井本直人、稲垣裕一郎、杉本慶樹、直江知樹、清井仁
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Ph陽性白血病に対するAIC-47のbcr-abl転写抑制とイマチニブの併用効果2015
- Author(s)
  篠原悠、熊崎実南、谷口高平、倉永祐希、岩附綾子、酒井美来、直江知樹、赤尾幸博.
- Organizer
  第19回日本がん分子標的治療学会
- Place of Presentation
  松山全日空ホテル(愛媛県松山市)
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Ph陽性ALL新規治療薬発見のためのPDXスクリーニングによるドラッグリポジショニング.2015
- Author(s)
  森下喬允、早川文彦、杉本慶樹、直江知樹、清井仁.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] イマチニブ非感受性白血病に対する新規脂肪酸誘導体AIC-47の増殖抑制作用2015
- Author(s)
  篠原悠、南陽介、直江知樹、赤尾幸博.
- Organizer
  第53回日本癌治療学会
- Place of Presentation
  国立京都国際会館(京都府京都市)
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Mesenchymal stem cells stably transduced with a dominant negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage2013
- Author(s)
  Nakayama T, Saito S, Naoe T
- Organizer
  第61回日本輸血・細胞療法学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591382
[Presentation] A novel STAT inhibitor, OPB-31121, has a significant anti-tumor effect on STAT-dependent leukemia.2013
- Author(s)
  Fumihiko Hayakawa, Keiki Sugimoto, Shingo Kurahashi, Tomoki Naoe.
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Tratment with Hedgehog inhibitor,PF-04449913, atteuates leukemia-initiation potential in acute mveloid leukemia cells2013
- Author(s)
  Nobuaki Fukushima,Yosuke Minami,Fumihiko Hayakawa,Hitoshi Kiyoi, Anil Sadarangani, PhD3*, Catriona HM Jamieson,Tomoki Naoe
- Organizer
  米国血液学会
- Place of Presentation
  ニューオリンズ
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] リンパ腫細胞環境をターゲットする薬剤開発2013
- Author(s)
  杉本慶樹、早川文彦　直江知樹
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] 正常及び変異FLT３共発現細胞の細胞増殖及びFLT3阻害剤効果に対するFLの抑制効果2013
- Author(s)
  陳昉里、中谷俊幸、木原里香、清井仁、直江知樹
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Analysis of rituximab resistance mechanism in CD20 positive B-cell lymphoma cells.2013
- Author(s)
  Kazuyuki Shimada, Akihiro Tomita, Takashi Tokunaga, Chisako Iriyama, Tomohiro Kinoshita, Hitoshi kiyoi, Cragg Mark, Tomoki Naoe.
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Ri tuxi mab Sensitivity to De Novo DLBCL Cells Showing the Specific Phenotype of CD20 Protein Immunohistochemistry-Positive / Flow Cytometory-Negative: Analyses of Its Clinical Significances and the Molecular Mechanisms2012
- Author(s)
  Tomi ta A, Naoe T,et al
- Organizer
  The American Society of Hematology 54th Annual Meeting
- Place of Presentation
  Atlanta USA
- Year and Date
  2012-12-09
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib2012
- Author(s)
  Nakayama T, Mizuno H, Naoe T
- Organizer
  第34回日本血栓止血学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591382
[Presentation] Drug Development Targeting Microenvironment for Malignant Lymphoma ASH Annual Meeting Abstracts 2012 120:16612012
- Author(s)
  Keiki Sugimoto, Fumihiko Hayakawa, Takahiko Yasuda, and Tomoki Naoe
- Organizer
  The American Society of Hematology 54th Annual Meeting
- Place of Presentation
  Atlanta (USA)
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] Rituximab Sensitivity to De Novo DLBCL Cells Showing the Specific Phenotype of CD20 Protein Immunohistochemistry-Positive / Flow Cytometory-Negative: Analyses of Its Clinical Significances and the Molecular Mechanisms.2012
- Author(s)
  Tomita A, Naoe T,et al.
- Organizer
  The American Society of Hematology 54th Annual Meeting.
- Place of Presentation
  Atlanta USA
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Correlation of serum IL-6 with exhaustion of CMV-specific T cells after allogeneic stem cell transplantation2012
- Author(s)
  Nishida T, Naoe T,et al
- Organizer
  平成24年日本血液学会.
- Place of Presentation
  国立京都国際会議場(京都市)
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Outcome of Pediatric-Type Therapy for Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults (AYA): A Study by the Japan Adult Leukemia Study Group (JALSG ALL202-U study)2012
- Author(s)
  Sakura T, Naoe T,et al
- Organizer
  The American Society of Hematology 54th Annual Meeting
- Place of Presentation
  Atlanta USA
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] The effectiveness of macrophage-targeted therapy by dexamethasone palmitate for refractory GVHD2012
- Author(s)
  Takayuki Nakayama, Satoshi Nishiwaki, Makoto Murata, Tetsuya Nishida, Seitaro Terakura, Shigeki Saito, Tomoki Naoe et al.
- Organizer
  The 74th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23591382
[Presentation] Wnt signaling is associated with anti-apoptosis in the interaction between acute myeloid leukemia cells and stromal cells2012
- Author(s)
  Minami Y, Naoe T, et al
- Organizer
  The American Society of Hematology 54th Annual Meeting
- Place of Presentation
  Atlanta USA
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Usefulness of Peripheral Blood Circulating DNAs As an Alternative to DNA From Bone Marrow Cells to Detect CpG Global Methylation Status and Genetic Mutations in Patients with Myelodysplastic Syndromes.2012
- Author(s)
  Iriyama C, Tomita A, Naoe T, et al.
- Organizer
  The American Society of Hematology 54th Annual Meeting.
- Place of Presentation
  Atlanta USA
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Incidence and Clinical Features of Core Binding Factor Acute Myeloid Leukemia: A Collaborative Study of the Japan Adult Leukemia Study Group and the Korean Society of Hematology2012
- Author(s)
  Taki T, Kiyoi H, Naoe T, et al
- Organizer
  The American Society of Hematology 54th Annual Meeting
- Place of Presentation
  Atlanta USA
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] EVI1 elicits resistance to apoptosis which can be overcome through application of AKTi or ABT-7372012
- Author(s)
  島田和之,直江知樹,他
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Usefulness of Peripheral Blood Circulating DNAs As an Alternative to DNA From Bone Marrow Cells to Detect CpG Global Methylation Status and Genetic Mutations in Patients with Myelodysplastic Syndromes2012
- Author(s)
  Iriyama C, Tomita A, Naoe T,et al
- Organizer
  The American Society of Hematology 54th Annual Meeting
- Place of Presentation
  Atlanta USA
- Year and Date
  2012-12-10
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Drug Development Targeting Microenvironment for Malignant Lymphoma ASH Annual Meeting Abstracts 2012 120:16612012
- Author(s)
  Sugimoto K, Hayakawa F, Yasuda T, and Naoe T.
- Organizer
  第54回アメリカ血液学会
- Place of Presentation
  Atlanta (USA)
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] Wnt Signaling Is Associated with Anti-Apoptosis in the Interaction Between Acute Myeloid Leukemia Cells and Stromal Cells2012
- Author(s)
  Yosuke Minami, Yosuke Niwa, Akihiro Abe, Fumihiko Hayakawa, and Tomoki Naoe
- Organizer
  The American Society of Hematology 54th Annual Meeting
- Place of Presentation
  Atlanta (USA).
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] The effectiveness of macrophage-targeted therapy by dexamethasone palmitate for refractory GVHD2012
- Author(s)
  Nishiwaki S, Nakayama T, Naoe T.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591382
[Presentation] Leukaemia escape from HLA-specific T-lymphocyte pressure in a recipient of HLA one locus-mismatched BMT2012
- Author(s)
  Murata M, Naoe T,et al
- Organizer
  The 38th Annual Meeting of the European Group for Blood and Marrow Transplantation.
- Place of Presentation
  Geneva, Switzerland
- Year and Date
  2012-04-01
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Wnt Signaling Is Associated with Anti-Apoptosis in the Interaction Between Acute Myeloid Leukemia Cells and Stromal Cells.2012
- Author(s)
  Minami Y, Niwa Y, Abe A, Hayakawa F, and Naoe T.
- Organizer
  第54回アメリカ血液学会
- Place of Presentation
  Atlanta (USA)
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] 造血支持を目的としたヒト脂肪組織由来間葉系幹細胞の有効性、安全性の検討2011
- Author(s)
  中山享之、中尾典彦、直江知樹
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591382
[Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells2011
- Author(s)
  Hayakawa F, Sugimoto K, Kurahashi S, Sumida T, Naoe T.
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] CD20 Protein Immunohistochemistry-Positive/Flow Cytometry-Negative Diffuse Large B-Cell Lymphoma-Analyses of the Molecular Mechanisms and Rituximab Effectiveness2011
- Author(s)
  Tokunaga T, Naoe T,et al
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego USA
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells.2011
- Author(s)
  Hayakawa F, Sugimoto K, Kurahashi S, Sumida T, Naoe T.
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] RhoH Downregulates Rac Through RhoGAP Family Protein.2011
- Author(s)
  Katsumi A, Kobayashi M, Matsushita T, Kiyoi H, Kojima T, Maruyama M, Kaibuchi K, Naoe T.
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] RhoH Downregulates Rac Through RhoGAP Family Protein2011
- Author(s)
  Katsumi A, Naoe T,et al
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego USA
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Retention of Slow-Cycling CD34+ cells During Imatinib Treatment and Rapid Decline After 2ndABL-TKI Treatment in Ph+ Leukemia Cells2011
- Author(s)
  Minami Y, Abe A, Minami M, Kuwatsuka Y, Fukushima N, Kitamura K, Hiraga J, Yamamoto K, Jamieson C, Naoe T
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] Retention of Slow-Cycling CD34+ cells During Imatinib Treatment and Rapid Decline After 2nd ABL-TKI Treatment in Ph+ Leukemia Cells2011
- Author(s)
  Minami Y, Naoe T,et al
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego USA
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells2011
- Author(s)
  Hayakawa F, Naoe T,et al
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego USA
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Retention of Slow-Cycling CD34+ cells During Imatinib Treatment and Rapid Decline After 2nd ABL-TKI Treatment in Ph+ Leukemia Cells.2011
- Author(s)
  Minami Y, Abe A, Minami M, Kuwatsuka Y, Fukushima N, Kitamura K, Hiraga J, Yamamoto K, Jamieson C, Naoe T.
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23659487
[Presentation] A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells2011
- Author(s)
  Hayakawa F, Naoe T, et al
- Organizer
  53^<rd> ASH Annual Meeting and Exposition
- Place of Presentation
  San Diego, CA U.S.A
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Biomarkers In Cell Death of Imatinib-Resistant Ph-Leukemia Cells During Treatment with mTOR Inhibitor, Everolimus2010
- Author(s)
  Miho M, Naoe T, et al
- Organizer
  The American Society of Hematology 53th Annual Meeting
- Place of Presentation
  Orlando USA
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Biomarkers In Cell Death of Imatinib-Resistant Ph-Leukemia Cells During Treatment with mTOR Inhibitor, Everolimus.2010
- Author(s)
  Miho M, Naoe T, et al.
- Organizer
  52nd ASH Annual Meeting and Exposition
- Place of Presentation
  Orlando, FL U.S.A
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-22390192
[Presentation] Evaluation of BCR-ABL-positive leukemia stem cells with imatinib-therapy and apoptosis induced by bortezomib-treatment2009
- Author(s)
  南陽介, 安部明弘, 鍬塚八千代, 野村由佳, 谷崎亮平, 直江知樹
- Organizer
  第7回幹細胞シンポジウム(一般演題)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Treatment with mTOR Inhibitor, Everolimus (RAD001) Overcomes Resistance to Imatinib in Ph-Leukemia Quiescent or T315I-Mutated Cells2009
- Author(s)
  Minami Y, Naoe T, et al.
- Organizer
  The American Society of Hematology 51th Annual Meeting
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] Double Genetic Mutations in PML-Rara Fusion Gene Confirmed in a Patient Showing Resistance to All-Trans Retinoic Acid and Arsenic-Trioxide Therapy2009
- Author(s)
  Goto E, Naoe T, et al.
- Organizer
  The American Society of Hematology 51th Annual Meeting
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] Ph陽性白血病幹細胞におけるイマチニブ耐性とボルテゾミブによる克服の可能性2009
- Author(s)
  南陽介, 鍬塚八千代, 谷崎亮平, 野村由佳, 安部明弘, 清井仁, 直江知樹
- Organizer
  第18回日本アポトーシス研究会(一般口演)
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Treatment with BortezomibOvercomes Resistance to Imatinib in Ph-Leukemia Quiescent Cells2009
- Author(s)
  Kuwatsuka Y, Naoe T, et al.
- Organizer
  The American Society of Hematology 51th Annual Meeting
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] MS4A1 (CD20) Gene Expression Is Down-Regulated by Recruiting the Histone Deacetylase Protein Complex to the Promoter in the CD20-Negative B-Lymphoma Cells After Treatment with Rituximab2009
- Author(s)
  Sugimoto T, Naoe T, et al.
- Organizer
  The American Society of Hematology 51th Annual Meeting
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] FLT3/ITD Regulates Leukemia Cell Adhesion throughα4β1 Integrin and Pyk2 Signaling2009
- Author(s)
  Katsumi A, Kiyoi H, Abe A, Naoe T
- Organizer
  The 51st ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, LA
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Treatment with mTOR Inhibitor, Everolimus (RAD001) Overcomes Resistance to Imatinib in Ph-Leukemia Quiescent or T315I-Mutated Cells2009
- Author(s)
  Minami Y, Minami M, Kuwatsuka Y, Tanizaki R, Nomura Y, Abe A, Kiyoi H, Naoe T
- Organizer
  The 51st ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] FLT3/ITD Regulates Leukemia Cell Adhesion throughα4β1 Integrin and Pyk2 Signalin2009
- Author(s)
  Katsumi A, Naoe T, et al.
- Organizer
  The American Society of Hematology 51th Annual Meeting
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] FL-Dependent Wild-Type FLT3 Signals Reduce the Inhibitory Effects of FLT3 Inhibitors On Wild-Type and Mutant FLT3 Co-Expressing Cel2009
- Author(s)
  Mori Y, Naoe T, et al.
- Organizer
  The American Society of Hematology 51th Annual Meeting
- Place of Presentation
  New Orleans USA
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] Ph陽性白血病幹細胞におけるイマチニブ耐性とボルテゾミブによる克服の可能性2009
- Author(s)
  南陽介鍬塚八千代谷崎亮平安部明弘直江知樹
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜(一般口演)
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Treatment with Bortezomib Overcomes Resistance to Imatinib in Ph-Leukemia Quiescent Cells2009
- Author(s)
  Kuwatsuka Y, Minami Y, Tanizaki R, Minami M, Abe A, Nomura Y, Kiyoi H, Naoe T
- Organizer
  The 51st ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, LA
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Hsp90 inhibitor, 17-AAG overcome resistance of FLT3-inhibitor in MOLM13N676K2008
- Author(s)
  Y Minami, Y Nomura, A Abe, R Tanizaki, Y Shiotsu, S Akinaga, H Kiyoi, T Naoe
- Organizer
  50th ASH meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] FLT3/ITD regulates leukemia cell adhesion through a4b1 integrin and Pyk2 signaling2008
- Author(s)
  勝見章、清井仁、安部明弘、谷崎亮平、松下正、小嶋哲人、直江知樹
- Organizer
  第71回日本血液学会学術総会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] KW-2449, a Novel Multi-Kinase Inhibitor, Suppresses the Growth of Imatinib-Resistant Ph+ Leukemia Including BCR-ABL/T315I Both in Vitro and in Vivo2008
- Author(s)
  Shiotsu Y and Naoe T, et.al.
- Organizer
  ASH Annual Meeting 2008
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-17016029
[Presentation] Philadelphia染色体陽性急性リンパ芽球性白血病由来Imatinib耐性株の樹立とその耐性化機序の解析2008
- Author(s)
  西岡百子、安部明弘、今釜静香、谷崎亮平、勝見章、南陽介、早川文彦、山本一仁、直江知樹
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Transformation of E2A-deficient pluripotent progenitors by BCR-ABL generates imatinib-resistant leukemic stem cells2008
- Author(s)
  Minami Y, Abe A, Ikawa T, Stuart S, Jamieson CHM, Naoe T
- Organizer
  Wang JYJ 50th ASH meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Evaluation of residual leukemia stem cells in chronic myeloid leukemia with imatinib therapy2008
- Author(s)
  南陽介, 安部明弘, 鍬塚八千代, 早川文彦, 谷崎亮平, 勝見章, 清井仁, 直江知樹
- Organizer
  第67回日本癌学会総会(ワークショップ)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] 慢性骨髄性白血病幹前駆細胞に対するイマチニブの効果:マウス多能性造血細胞モデル及び治療後残存腫瘍解析2008
- Author(s)
  南陽介、安部明弘、伊川友活、Scott Stuart, 早川文彦、北村邦朗、野村由佳、Catriona Jamieson, Jean Wang, 直江知樹
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-19390261
[Presentation] Markedly Improved Outcome and Acceptable Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia by Treatment with a Pediatric Protocol: a Phase Ⅱ Study by the Japan Adult Leukemia Study Group.
- Author(s)
  Hayakawa Fumihiko、 Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Shuichi Miyawaki, So-ichi Suenobu, Shigeki Ohtake, Yukio Kobayashi, keitaro Matsuo, and Tomoki Naoe
- Organizer
  第5回日本血液学会（JSH)国際シンポジウム
- Place of Presentation
  アクトシティ浜松（静岡県浜松市中区）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib
- Author(s)
  Nakayama T, Mizuno H, Naoe T
- Organizer
  Keystone Symposia
- Place of Presentation
  Vancouver, BC, Canada
- Data Source
  KAKENHI-PROJECT-23591382
[Presentation] Biological and genetic analyses of intravascular large B-cell lymphoma using xenograft mouse model.
- Author(s)
  島田和之、島田聡子、杉本慶樹、早川文彦、片山幸、平川晃弘、中村栄男、瀬戸加大、直江知樹、冨田章裕、清井仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal.
- Author(s)
  稲垣裕一郎、早川文彦、井本直人、森下喬允、直江知樹、清井仁
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Biological and genetic analyses of intravascular large B-cell lymphoma using xenograft mouse model.
- Author(s)
  島田和之、島田聡子、杉本慶樹、早川文彦、片山幸、平川晃弘、中村栄男、瀬戸加大、直江知樹、冨田章裕、清井仁
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市北区）
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] Markedly Improved Outcome and Acceptable Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia by Treatment with a Pediatric Protocol: a Phase Ⅱ Study by the Japan Adult Leukemia Study Group.
- Author(s)
  Hayakawa Fumihiko、 Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Shuichi Miyawaki, So-ichi Suenobu, Shigeki Ohtake, Yukio Kobayashi, keitaro Matsuo, and Tomoki Naoe
- Organizer
  第5回日本血液学会（JSH)国際シンポジウム
- Place of Presentation
  アクトシティ浜松（静岡県浜松市中区）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-25293218
[Presentation] Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2R γnull Mouse Xenograft Model.
- Author(s)
  Kazuyuki Shimada, Satoko Shimada, Keiki Sugimoto, Fumihiko Hayakawa, Miyuki Katayama, Akihiro Hirakawa, Yusuke Takagi, Shigeo Nakamura, Masao Seto, Tomoki Naoe, Akihiro Tomita, Hitoshi Kiyoi
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] PAX5 Tyrosine Phosphorylation By Syk Co-Operatively Works with Its Serine Phosphorylation By ERK1/2 and Cancels PAX5-Dependent Repression of BLIMP1: A Mechanism of Antigen-Triggering Plasma Cell Differentiation through B Cell Receptor Signal.
- Author(s)
  稲垣裕一郎、早川文彦、井本直人、森下喬允、直江知樹、清井仁
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25670449
[Presentation] Development and Analysis of Novel Intravascular Large B-Cell Lymphoma NOD/Shi-Scid IL2R γnull Mouse Xenograft Model.
- Author(s)
  Kazuyuki Shimada, Satoko Shimada, Keiki Sugimoto, Fumihiko Hayakawa, Miyuki Katayama, Akihiro Hirakawa, Yusuke Takagi, Shigeo Nakamura, Masao Seto, Tomoki Naoe, Akihiro Tomita, Hitoshi Kiyoi
- Organizer
  第56回米国血液学会
- Place of Presentation
  Moscone Center （サンフランシスコ、米国）
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25293218

1. OHNO Ryuzo (70093002)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. KIYOI Hitoshi (90314004)

# of Collaborated Projects: 6 results

# of Collaborated Products: 18 results
3. KITAMURA Kunio

# of Collaborated Projects: 5 results

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4. 福谷久

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5. 久保和明

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6. TOMITA Akihiro (80378215)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
7. 本間良夫 (70142114)

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8. 武藤泰敏 (20010069)

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9. 橋本祐一 (90164798)

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10. 大林包幸

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11. 市橋卓司

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# of Collaborated Products: 0 results
12. KATSUMI Akira (80378025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
13. HAYAKAWA Fumihiko (30402580)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
14. SHIMADA Kazuyuki (50631503)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
15. EMI Nobuhiko (30185144)

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# of Collaborated Products: 0 results
16. TANIMOTO Mitune (10240805)

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17. 垣塚彰 (80204329)

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18. 堀部敬三 (30209308)

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19. REES John K

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. MINAMI Yousuke (60513752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
21. NAKAYAMA Takayuki (00456659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
22. AKAO Yukihiro (00222505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
23. TAKESHITA Akihiro (00242769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. OHNISHI Kazunori (80252170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. SAITO Hidehiko (20153819)

# of Collaborated Projects: 1 results

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26. ITO Mamoru (00176364)

# of Collaborated Projects: 1 results

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27. KOJIMA Seiji (20313992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KAMACHI Yoshiro (20343204)

# of Collaborated Projects: 1 results

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29. ABE Akihiro (00432261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. YAMAMOTO Kauzhito (60250247)

# of Collaborated Projects: 1 results

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31. KAIBUCHI Kozo (00169377)

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32. SHIKU Hiroshi (80154194)

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33. ICHIMARU Michito (50039525)

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34. MIENO Masahiro (60039576)

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35. 黒沢良和 (10109259)

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36. 加藤芳郎 (20152754)

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37. 梅沢一夫 (70114402)

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38. 上田龍三 (20142169)

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39. 佐藤滋樹 (80254283)

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40. 折戸悦郎 (60204294)

# of Collaborated Projects: 1 results

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41. 吉川和宏 (60109759)

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42. 王伯銘 (60223707)

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43. 栗山一孝 (90128174)

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44. 朝長万左男 (40100854)

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45. SHOU Dong

# of Collaborated Projects: 1 results

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46. CHEN Sai-juan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. CHEN Zhu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. WANG Zen-yi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. DEGOS Laurent

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. BURNETT Alan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. HOROWITZ Mary

# of Collaborated Projects: 1 results

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52. 唐渡雅行

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 森下剛久

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 大野龍三

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. CHUO Dong

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
56. SHI Lei

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# of Collaborated Products: 1 results
57. ITO Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
58. OTSUKI Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. SUZUKI Yasuhiro

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# of Collaborated Products: 1 results
60. ANDO Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. MIYAZAKI Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
62. 長谷川好規

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# of Collaborated Products: 1 results
63. 橋本直純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
64. 小川誠司

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# of Collaborated Products: 1 results
65. 麻生範雄

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# of Collaborated Products: 1 results
66. 片貝智哉

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# of Collaborated Products: 1 results
67. 水野正明

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# of Collaborated Products: 1 results
68. 豊國伸哉

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# of Collaborated Products: 1 results
69. 寺倉精太郎

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# of Collaborated Products: 1 results
70. 都筑忍

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# of Collaborated Products: 1 results
71. 山本幸也

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# of Collaborated Products: 1 results
72. 瀬戸加大

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# of Collaborated Products: 1 results
73. 西脇聡史

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# of Collaborated Products: 1 results
74. 村田誠

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# of Collaborated Products: 2 results
75. 岩永正子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
76. 岡部聖一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
77. 前川平

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# of Collaborated Products: 1 results

NAOE Tomoki 直江 知樹

Research Projects

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Translational research toward drug discovery of leukemiaPrincipal Investigator

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Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cellsPrincipal Investigator

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Development of innovative anti-tumor agents that target signal transducers and activator of transcriptionPrincipal Investigator

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Basic research aimed at understanding and overcoming of the primary and secondary resistance in molecular target therapyPrincipal Investigator

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Molecular mechanisms and therapeutic approach of residual leukemiaPrincipal Investigator

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Research & Development of molecular target therapy for leukemia and Its assessment SystemPrincipal Investigator

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Analysis of aberrant signal tansduction in hematological malignancy and development of treatment methods.Principal Investigator

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白血病に選択性を有する分子標的治療法ならびにその評価法の開発Principal Investigator

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Establishment of a leukemia model mouse by introducing mutated FLT3 genePrincipal Investigator

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NAOE Tomoki 直江知樹