UMEZAWA Umezawa 梅澤一夫

… Alternative Names

梅沢一夫ウメザワカズオ

UMEZAWA Kazuo 梅澤一夫

Less

Researcher Number	70114402
External Links
Affiliation (based on the past Project Information) *help	2022 – 2023: 愛知医科大学, 医学部, 教授 2012 – 2019: 愛知医科大学, 医学部, 教授 2004 – 2011: 慶應義塾大学, 理工学部, 教授 2010: 慶応義塾大学, 理工学部, 教授 2008: 慶応義塾大学, 理工学部, 教授 … More 2004: 慶応義塾大学, 理工学部, 教授 2003: 慶応大学, 理工学部, 教授 2000 – 2002: 慶應義塾大学, 理工学部, 教授 1999 – 2000: 慶応義塾大学, 理工学部, 教授 1995 – 1996: 慶応義塾大学, 理工学部, 教授 1994: 慶應義塾大学, 理工学部, 教授 1991 – 1992: 慶応義塾大学, 理工学部, 教授 1990 – 1992: 慶応大学, 理工学部, 教授 1987: Institute for Microbial Chemistry, 副所長 1986: 東京大学, 医科学研究所, 助教授 Less
Review Section/Research Field	Principal Investigator Science and Engineering / Chemical biology / Chemical biology / Chemical biology Except Principal Investigator General surgery / 医薬分子機能学 / 医学一般 / Basic Section 53010:Gastroenterology-related / 広領域 / Urology … More / Living organism molecular science / Chemical biology / 膠原病・アレルギー・感染症内科学 / Biomedical engineering/Biological material science Less
Keywords	Principal Investigator DHMEQ / 転移 / 浸潤 / NF-kappa B / 分子デザイン / NF-κB / スクリーニング / 放線菌 / 阻害剤 / Exo-ene EQ … More / 遊走 / 卵巣癌 / 微生物 / 生理活性物質 / 有機化学 / 癌 / 抗癌剤 / メラノーマ / コノフィリン / IKK-beta / ketomycin / I-kappa B kinase / 三次元培養 / がん細胞 / (-)-DHMEQ / SEMBL / 分子標的 / desmal / 炎症 / がん / 天然物 / 光プローブ / 標的タンパク質 / 探索プローブ / アノイキス / 卵巣がん / pyrapaxilline / migracin / DTCM-glutarimide / 腹腔内転移 / バイオイメージング / 腹腔内播種 / リポ多糖 / ヘプタデプシン / インスリン / エポキシキノマイシン / 生理活性 / シグナル伝達 / 糖尿病 / 細胞・組織 / 応用微生物 / 膵腺癌細胞 / 生合成 / 植物 / アポトーシス / H抗原 / 子宮体がん / レクチン / がん遺伝子 / Con A結合蛋白 / ルイス肺がん / マウスメラノーマ / α-グルコシダーゼ / エピサイクロフェリトール … More Except Principal Investigator NF-κB / 磁気泳動細胞分離 / 活性酸素 / 貧食能 / 単球 / PI代謝回転阻害剤 / 侵入阻害剤 / 胆汁酸誘導体 / ウイルス侵入機構 / 感染制御 / 侵入阻害 / 侵入機構 / B型肝炎ウイルス / Glycoprotein / Cell spreading / Cell attachment / Fibronectin / 血液 / 細胞間マトリックス / 細胞表面 / タンパク質 / 接着性糖タンパク質 / 血漿タンパク質 / 糖タンパク質 / 細胞伸展 / 細胞接着 / フィブロネクチン / cytokine / metastasis / apoptosis / urological malignancy / 殺細胞効果 / 膀胱癌 / STAT3 / IL-6 / 細胞周期 / 放射線治療 / 前立腺癌 / 悪液質 / 転移 / アポトーシス / 泌尿器系癌 / inhibitor / acidic sphyngomyelinase / microbial product / 酸性スフィンゴミエリナーゼ / スフィンゴミエリナーゼ / 阻害剤 / 微生物代謝産物 / Ras protein / oncogene / farnesyltransferase / man-made chelator / Ras蛋白質 / 癌遺伝子 / ファルネシルトランスフェラーゼ / 人工配位子 / 構造活性相関 / 骨転移 / 骨粗鬆症 / 低分子化合物 / 骨疾患 / RANKL / ケミカルバイオロジー / 破骨細胞分化 / 破骨細胞 / Pirin / 骨関連疾患 / CD40 / 分子標的治療 / 膵ラ氏島移植 / ケモカイン / 血小板機能 / シグナル伝達阻害薬 / 抗β2グリコプロテインI抗体 / NF-kappaB / 動物モデル / 抗β2-グリコプロテインI抗体 / 抗リン脂質抗体症候群 / 虚血・再かん流障害 / DHMEQ / NF-KB / 虚血再灌流 / NF kappa B / 拒絶反応 / 肝移植 / 臓器移植 / 虚血再灌流障害 / 臓器保存 / 免疫抑制 / NF-kB / 足場構造 / コラーゲン / 基質 / バイオメカニクス / コラーゲンゲル / 低酸素 / 内皮前駆細胞 / 血管新生 / 再生医療 / 毛細血管 / 内皮細胞 / 合成化学 / 画像 / シグナル伝達 / 螢光 / 機能性分子 / 生体機能 / レチノイドアンタゴニスト / 亜砒酸 / RARA / PML / 細胞内レチノイン酸結合蛋白 / Am-80 / 急性前骨髄球性白血病 / 分化誘導療法 / レチノイン酸 / フローサイトメータ / モノクローナル抗体 / Fcレセプター / 免疫 / フラバノン化合物デスマール / アポプトーシス / エンドヌクレアーゼ / 糖転移酵素系 / 非リン酸化RB遺伝子産物 / チロシンキナーゼ阻害剤 / 糖鎖含有リコンビナントD因子 / フロ-サイトメ-タ / モノクロ-ナル抗体 / Fcレセプタ- / 免疫機能 / インスリン受容体βサブユニット自己リン酸化反応 / 造血因子MーCSF / トランスフォ-ミング増殖因子(TGF)β / 活性型ビタミンD3 / 抗癌剤排出性P糖蛋白 / 特異的チロシンキナ-ゼ阻害物質 / 脂質性合成シアロ糖化合物 / 分化誘導剤 / ラット骨髄前脂肪細胞株RECAー16 / アポプト-シス / AraC感受性 / MDS由来細胞株 / ミオシンL鎖キナ-ゼ阻害剤 / 蛋白リン酸化酵素阻害剤 / ピリミジンヌクレオシド化合物 Less

Elucidation of the mechanism of hepatitis B virus entry and control of infection by entry inhibitors
- Principal Investigator
  
  伊藤清顕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Aichi Medical University
Screening of cancer cell 3D invasion inhibitors from microbial metabolitesPrincipal Investigator
- Principal Investigator
  
  Umezawa Kazuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
Screening of NF-kappa B inhibitors having new core structure and application to aggressive cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Umezawa Kazuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
Development of novel drug for bone-related diseases using Pirin inhibitors
- Principal Investigator
  
  SIMIZU Siro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Keio University
Bio-imaging of peritoneal metastasis and molecular design of inhibitorsPrincipal Investigator
- Principal Investigator
  
  UMEZAWA Kazuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Aichi Medical University
  Keio University
Development of a new strategy for pancreatic islet transplantation by molecular targeting agents
- Principal Investigator
  
  YAMASHITA Kenichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Hokkaido University
Studies on thrombophilic diathesis and development of a novel molecular-targeting therapy in antiphospholipid syndrome
- Principal Investigator
  
  KUBOTA Tetsuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical and Dental University
Molecular design and synthesis of soluble NF-κB inhibitor and suppression of ovarian carcinomaPrincipal Investigator
- Principal Investigator
  
  UMEZAWA Kazuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Keio University
Development of safe liver transplantation by modulation of transcription factor, nuclear factor kappa B (NF-kB)
- Principal Investigator
  
  TODO Satoru
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Hokkaido University
力学的刺激による毛細血管3次元ネットワーク形成の促進と再生医療への応用
- Principal Investigator
  
  谷下一夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Keio University
天然由来シグナル伝達阻害物質の探索と医薬への応用Principal Investigator
- Principal Investigator
  
  梅澤一夫 (梅沢一夫)
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Keio University
Pathophysiological role of NF k B and the efficacy of a novel NF K B inhibitor in urological cancers
- Principal Investigator
  
  MURAI Masaru
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Keio University
Screening for selective acidic sphyngomyelinase inhibitor using microbial product
- Principal Investigator
  
  IKEDA Yoko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Microbial Chemistry Research Foundation
癌細胞のアポトーシス耐性および分化誘導耐性克服物質の探索Principal Investigator
- Principal Investigator
  
  梅澤一夫 (梅沢一夫)
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Keio University
微生物、植物由来アポトーシス耐性克服物質の探索Principal Investigator
- Principal Investigator
  
  梅沢一夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Keio University
画像化能を有する生体機能探査分子の設計原理の開発
- Principal Investigator
  
  樋口恒彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Molecular Design of Ras Farnesyltransferase Inhibitors
- Principal Investigator
  
  OTSUKA Masami
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
糖鎖生合成修飾による転移の抑制Principal Investigator
- Principal Investigator
  
  梅沢一夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
糖鎖生合成修飾による転移の抑制Principal Investigator
- Principal Investigator
  
  梅沢一夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Keio University
細胞分化誘導剤の臨床応用に関する基礎的研究
- Principal Investigator
  
  斉藤政樹
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
磁気および発光プローブを用いた担癌生体免疫能分析システムの研究
- Principal Investigator
  
  南谷晴之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医学一般
- Research Institution
  Keio University
細胞分化誘導剤の臨床応用に関する基礎的研究
- Principal Investigator
  
  斎藤政樹
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
磁気効果と発光現象を利用した担癌生体免疫測定システムの開発と総合的な分析
- Principal Investigator
  
  南谷晴之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医学一般
- Research Institution
  Keio University
Physiology and Biochemistry of Fibronectin; Comprehensive Approaches from Basic to Clinical Studies.
- Principal Investigator
  
  MASAO Hayashi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  広領域
- Research Institution
  Ochanomizu University

[Book] 抗悪性腫瘍薬の作用機構解析法。曽根三郎、鶴尾隆編:がん分子標的治療研究実践マニュアル2009
- Author(s)
  梅澤一夫
- Total Pages
  4
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20611015
[Book] 新しい抗癌剤の分子標的NF-κB。菅野純夫編:臨床遺伝子学'09-がんの遺伝子学-最新医学9月増刊号2009
- Author(s)
  鈴木絵里子, 梅澤一夫
- Total Pages
  9
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-20611015
[Book] 位置・立体選択的反応を鍵段階とする酵素-化学複合合成法の開発、「複合糖質の化学と最新応用技術」(正田晋一郎、稲津敏行編)2009
- Author(s)
  橘田和憲, 濱田学, 梅澤一夫, 東利則, 須貝威
- Total Pages
  9
- Publisher
  シーエムシー
- Data Source
  KAKENHI-PROJECT-20611015
[Book] NF-кBの役割と阻害剤の抗癌活性。鶴尾隆編「癌の分子標的」2008
- Author(s)
  鈴木絵里子, 梅澤一夫
- Total Pages
  6
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-20611015
[Book] Chemo-immunosensitization of resistant B-NHL as a result of rituximab (anti-CD20 mAb)-mediated inhibition of cell survival signaling pathways. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy2008
- Author(s)
  K. Umezawa, E. Suzuki
- Total Pages
  12
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20611015
[Book] NF-кBを標的とする抗癌剤。医学のあゆみ別冊2008
- Author(s)
  鈴木絵里子, 梅澤一夫
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-20611015
[Book] 生化学の基礎知識とケミカルバイオロジー。長田裕之編「入門ケミカルバイオロジー」2008
- Author(s)
  梅澤一夫
- Total Pages
  18
- Publisher
  オーム社
- Data Source
  KAKENHI-PROJECT-20611015
[Book] シグナル伝達阻害剤の単離、分子デザインと生物活性。上村大輔監修 : 新規素材探索-医薬品リード化合物・食品素材を求めて2008
- Author(s)
  梅澤一夫
- Total Pages
  11
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-20611015
[Book] 腐敗と再生2004
- Author(s)
  梅澤一夫
- Total Pages
  15
- Publisher
  慶應義塾大学出版会
- Data Source
  KAKENHI-PROJECT-16073217
[Book] シグナル伝達因子とがん治療薬開発-NF-kappa B阻害剤(-)-DHMEQバイオ医薬開発技術とシーズ
- Author(s)
  鈴木絵里子, 梅澤一夫
- Publisher
  CMC出版(印刷中)
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Effect of NF-κβ inhibitor-dehydroxymethylepoxyquinomicin on iron isomaltoside toxicity toward peritoneal mesothelial cells2024
- Author(s)
  Andrzej Breborowicz、Kazuo Umezawa
- Journal Title
  
  Renal Failure
  
  Volume: 46 Issue: 1
- DOI
  10.1080/0886022x.2024.2304647
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] Inhibitory effects of estetrol on the invasion and migration of immortalized human endometrial stromal cells2024
- Author(s)
  Wakatsuki A, Lin Y, Kojima S, Matsushita H, Takeuchi K, Umezawa K.
- Journal Title
  
  Endocr J
  
  Volume: 71 Issue: 2 Pages: 199-206
- DOI
  10.1507/endocrj.EJ23-0397
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19590, KAKENHI-PUBLICLY-22H04786, KAKENHI-PROJECT-23K24323
[Journal Article] Isolation of the Anti-Inflammatory Agent Myceliostatin from a Methionine-Enriched Culture of <i>Myceliophthora thermophila</i> ATCC 424642023
- Author(s)
  Wu Yanhua、Shen Junfeng、Wang Liyan、Lin Yinzhi、Kojima Shiori、Okada Shoshiro、Umezawa Kazuo
- Journal Title
  
  Journal of Natural Products
  
  Volume: 86 Issue: 2 Pages: 239-245
- DOI
  10.1021/acs.jnatprod.2c00811
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24323, KAKENHI-PROJECT-21K07531
[Journal Article] Inhibition of MLCK-mediated migration and invasion in human endometriosis stromal cells by NF-kB inhibitor DHMEQ2023
- Author(s)
  Lin Yinzhi、Kojima Shiori、Ishikawa Ayaka、Matsushita Hiroshi、Takeuchi Yuka、Mori Yuki、Ma Jun、Takeuchi Kosei、Umezawa Kazuo、Wakatsuki Akihiko
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] A foretaste for pediatric glioblastoma therapy: targeting the NF-kB pathway with DHMEQ2023
- Author(s)
  Brassesco Maria Sol、Roberto Gabriela Molinari、Delsin Lara Elis、Baldissera Gabriel Carlos、Medeiros Mariana、Umezawa Kazuo、Tone Luiz Gonzaga
- Journal Title
  
  Child's Nervous System
  
  Volume: - Issue: 6 Pages: 1519-1528
- DOI
  10.1007/s00381-023-05878-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity2022
- Author(s)
  Nakagawa Riko、Tateishi Hiroshi、Radwan Mohamed O.、Chinen Takuma、Ciftci Halilibrahim、Iwamaru Kana、Baba Nanami、Tominaga Yuna、Koga Ryoko、Toma Tsugumasa、Inoue Jun-ichiro、Umezawa Kazuo、Fujita Mikako、Otsuka Masami
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 7 Pages: 477-482
- DOI
  10.1248/cpb.c21-01087
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] Cellular Anti-Inflammatory and Antioxidant Activities of Bamboo Sasa albomarginata Leaf Extract and Its Constituent Coumaric Acid Methyl Ester2022
- Author(s)
  Kojima Shiori、Hakamata Masatoshi、Asanuma Toshimichi、Suzuki Rie、Tsuruda Jun-ichi、Nonoyama Takeshi、Lin Yinzhi、Fukatsu Hitomi、Koide Naoki、Umezawa Kazuo
- Journal Title
  
  The Scientific World Journal
  
  Volume: 2022 Pages: 1-10
- DOI
  10.1155/2022/8454865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] Natural Product from the Deep Sea2022
- Author(s)
  Kazuo Umezawa
- Journal Title
  
  Marine Drugs
  
  Volume: -
- DOI
  10.3390/books978-3-0365-3684-2
- ISBN
  9783036536842, 9783036536835
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model2020
- Author(s)
  S. Morita, K. Shinoda, T. Yoshida, M. Shimoda, Y. Kanno, R. Mizuno, H. Kono, H. Asanuma, K. Nakagawa, K. Umezawa, M. Oya
- Journal Title
  
  BMC Pharmacology and Toxicology
  
  Volume: in press
- DOI
  10.21203/rs.2.21990/v2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin2020
- Author(s)
  L. Wang, M. Li, Y. Lin, S. Du, Z. Liu, J. Ju, H. Suzuki, M. Sawada, K. Umezawa
- Journal Title
  
  J. Antibiot.
  
  Volume: in press Issue: 9 Pages: 622-629
- DOI
  10.1038/s41429-020-0302-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967, KAKENHI-PLANNED-18H05429
[Journal Article] Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin2020
- Author(s)
  K. Umezawa, Y. Lin
- Journal Title
  
  BBA-Proteins and Proteomics 1868 (2020) 140412
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Direct and indirect anticancer activity of plant-derived alkaloid conophylline2020
- Author(s)
  K. Umezawa, K. Shirabe
- Journal Title
  
  Critical Reviews in Oncogenesis
  
  Volume: in press Issue: 2 Pages: 67-72
- DOI
  10.1615/critrevoncog.2020034129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts2019
- Author(s)
  N. Ishii, K. Araki, T. Yokobori, K. Hagiwara, G. Dolgormaa, T. Yamanaka, T. Handa, M. Tsukagoshi, T. Igarashi, A. Watanabe, N. Kubo, N. Harimoto, A. Masamune, K. Umezawa, H. Kuwano, K. Shirabe
- Journal Title
  
  Cancer Science
  
  Volume: 10 Issue: 1 Pages: 334-434
- DOI
  10.1111/cas.13874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-18K16370, KAKENHI-PROJECT-16H06257, KAKENHI-PROJECT-17K10704
[Journal Article] Anti-Inflammatory effect of Dehydroxymethylepoxyquinomicin, a nuclear factor-kappa B inhibitor, on endotoxin-induced uveitis in rats in vivo and in vitro2019
- Author(s)
  Y. Ando, H. Keino, A. Kudo, A. Hitrakata, A. A. Okada, K. Umezawa
- Journal Title
  
  Occular Immunology & Inflammation
  
  Volume: in press Issue: 2 Pages: 240-248
- DOI
  10.1080/09273948.2019.1568502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K11490
[Journal Article] The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation2019
- Author(s)
  H. Fu, M. Alabdullah, J. Grosmann, F. Spieler, R. Abdosh, V. Lutz, K. Kalies, K. Knopp, K. Rieckmann, S. Koch, M. Nutsias, C. Pilowski, J. Dutzmann D. Sedding, S. Huttelmaier, K. Umezawa, K. Werdan, H. Loppnow
- Journal Title
  
  Cell Death and Disease
  
  Volume: 10 Issue: 12 Pages: 880-880
- DOI
  10.1038/s41419-019-2109-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum2019
- Author(s)
  H. He, X. Gao, X. Wang, X. Li, X. Jiang, Z. Xie, K. Ma, J. Ma, K. Umezawa, Y. Zhang
- Journal Title
  
  International Immunopharmacology
  
  Volume: 71 Pages: 43-51
- DOI
  10.1016/j.intimp.2019.03.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Growth inhibitory effects of dipotassium glycyrrhizinate in glioblastoma cell lines by targeting microRNAs through the NF-κB signaling pathway2019
- Author(s)
  G. A. Bonafe, J. S. dos Santos, J. V. Ziegler, K. Umezawa, M. L. Ribeiro, T. Rocha, M. M. Ortega
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 13
- DOI
  10.3389/fncel.2019.00216
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Causes and mechanisms of peritoneal fibrosis and possible application of NF-κB inhibitor for prevention and treatment2019
- Author(s)
  A. Breborowicz, K. Umezawa
- Journal Title
  
  Journal of Medical Science
  
  Volume: 88 Issue: 2 Pages: 102-108
- DOI
  10.20883/jms.352
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion2019
- Author(s)
  Y. Lin, Y. Chen, T. Ukaji, S. Okada, K. Umezawa
- Journal Title
  
  J. Antibiot.
  
  Volume: 72 Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC2019
- Author(s)
  S.-L. Ryan, S. Beard, M. P. Barr, K. Umezawa, S. Heavey, P. Godwin, S. G. Gray, D. Cormican, S. P. Finn, K. A. Gately, A. M. Davies, E. W. Thompson, D. J. Richard, K. J. O’Byrne, M. N. Adams, A.-M. Baird
- Journal Title
  
  Lung Cancer
  
  Volume: 135 Pages: 217-227
- DOI
  10.1016/j.lungcan.2019.07.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] The JAK/STAT3 and NF-kappa B signaling pathways regulate cancer stem cell properties in anaplastic thyroid cancer cells2019
- Author(s)
  K. Shiraiwa, M. Mitsutake, Y. Nakazawa, T. Ogi, K. Suzuki, V. Saenko, K. Umezawa, S. Yamashita, K. Tsukamoto
- Journal Title
  
  Thyroid
  
  Volume: in press Issue: 5 Pages: 674-682
- DOI
  10.1089/thy.2018.0212
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09913, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-19KK0267, KAKENHI-PROJECT-16H05832, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-16K08912, KAKENHI-PROJECT-16K09804
[Journal Article] Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models2018
- Author(s)
  K. Umezawa, I. Kojima, S. Simizu, Y. Lin, H. Fukatsu, N. Koide, Y. Nakade and M. Yoneda
- Journal Title
  
  Human Cell
  
  Volume: 31 Pages: 95-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] DTCM-glutarimide delays growth and radiosensitizes glioblastoma.2018
- Author(s)
  G. BM. Roberto, H. H. Paiva, L. E. B. deSouza, J. A. Pezuk, G. M. Vieira, H. F. deOliveira, K. Umezawa, L. G. Tone and M. S. Brassesco
- Journal Title
  
  Anti-cancer Agents in Medicinal Chemistry
  
  Volume: - Issue: 9 Pages: 1323-1329
- DOI
  10.2174/1871520618666180423105740
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-kappa B inhibition2018
- Author(s)
  X. Jiang, H. He, Z. Xie, H. Wen, X. Li, Xin Li, J. Ma, K. Umezawa, Y. Zhang
- Journal Title
  
  Immunopharmacology and Immunotoxicology
  
  Volume: in press Issue: 1 Pages: 32-39
- DOI
  10.1080/08923973.2018.1510962
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] The plant alkaloid conophylline inhibits matrix formation of fibroblasts2018
- Author(s)
  T. Tezuka, A. Ota, S. Karnan, K. Matsuura, K. Yokoo, Y. Hosokawa, D. Vigetti, A. Passi, S. Hatano, K. Umezawa, H. Watanabe
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 293 Pages: 20214-20226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Inhibition of late and early phases of cancer metastasis by NF-κB inhibitor DHMEQ derived from microbial bioactive metabolite epoxyquinomicin: A review.2018
- Author(s)
  Y. Lin, T. Ukaji, N. Koide and K. Umezawa
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: - Issue: 3 Pages: 729-729
- DOI
  10.3390/ijms19030729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice2018
- Author(s)
  T. Ohashi, Y. Nakade, M. Ibusuki, R Kitano, T. Yamauchi, S. Kimoto, T. Inoue, Y. Kobayashi, N. Ishii, Y. Sumida, K. Ito, H. Nakao, K. Umezawa, M. Yoneda
- Journal Title
  
  PLOS One
  
  Volume: electronic Issue: 1 Pages: e0210068-e0210068
- DOI
  10.1371/journal.pone.0210068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K09442
[Journal Article] NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model.2018
- Author(s)
  Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
- Journal Title
  
  Mol Med Rep
  
  Volume: 18 Pages: 5279-5285
- DOI
  10.3892/mmr.2018.9533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00937, KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K08866, KAKENHI-PROJECT-26305023
[Journal Article] Conophylline inhibits non-alcoholic steatohepatitis in mice.2017
- Author(s)
  Y. Nakade, K. Sakamoto, T. Yamauchi, Tadahisa Inoue, Y. Kobayashi, T. Yamamoto, N. Ishii, T. Ohashi; Y. Sumida; K. Ito, H. Nakao, Y. Fukuzawa, K. Umezawa and M. Yoneda
- Journal Title
  
  PLOS One
  
  Volume: 12(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Inhibition of MMP-2-mediated cellular invasion by NF-kappa B inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis2017
- Author(s)
  T. Ukaji, Y. Lin, S. Okada and K. Umezawa
- Journal Title
  
  Biochem. Biophys. Res. Commun. 485: 76-81, 2017
  
  Volume: 485 Pages: 76-81
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis.2017
- Author(s)
  T. Ikezoe, J. Yang, C. Nishioka, K. Umezawa and A. Yokoyama
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 52 Pages: 245-251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Novel p-terphenyl glycoside with a rare 2,6-dideoxy- hexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration.2017
- Author(s)
  L. Wang, M. Li, J. Tang, Y. Y. Lin, K. Sidthipong, N. Sumida, N. Kushida and K. Umezawa
- Journal Title
  
  J. Antibiot.
  
  Volume: 70 Pages: 987-990
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] The microenvironmental stromal cells abrogate NF-κB inhibitor induced apoptosis in chronic lymphocytic leukemia2017
- Author(s)
  C-P. Simon-Gabriel, K. Foerster, M. Benkisser-Petersen, D. Bleckmann, N. Thornton, K. Umezawa, S. Decker, C. Dierks, M. Burger, H. Veelken, R. Claus, J. Duyster, K. Zirlik
- Journal Title
  
  Hematologica
  
  Volume: - Issue: 1 Pages: 136-147
- DOI
  10.3324/haematol.2017.165381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.2017
- Author(s)
  K. Sidthipong, J. Ma, W. L. Yu, Y. F. Wang, S. Kobayashi, S. Kishino , N. Koide, T. Yokochi, K. Kato, S. Okada and K. Umezawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Pages: 562-567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.2017
- Author(s)
  M. El-Salhy, K. Umezawa, J. G. Hatlebakk and O. H. Gilja
- Journal Title
  
  Mol. Med. Reports
  
  Volume: 15 Pages: 2106-2112
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis2017
- Author(s)
  M. El-Salhy, K. Umezawa, J. G. Hatlebakk and O. H. Gilja
- Journal Title
  
  Mol. Med. Reports
  
  Volume: 15 Issue: 4 Pages: 2106-2112
- DOI
  10.3892/mmr.2017.6266
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Rational design, synthesis and in vitro evaluation of novelexo-methylene butyrolactone salicyloylamide as NF-κB inhibitor2017
- Author(s)
  K. Sidthipong, J. Ma, W. L. Yu, Y. F. Wang, S. Kobayashi, S. Kishino , N. Koide, T. Yokochi, K. Kato, S. Okada and K. Umezawa
- Journal Title
  
  Bioorg. Med. Chem. Lett. 27: 562-566, 2017.
  
  Volume: 27 Pages: 562-566
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.2017
- Author(s)
  T. Fujii, N. Fujita, S. Suzuki, K. Watanabe, T. Tsuji, K. Ishii, T. Takaki, K. Umezawa, T. Miyamoto, K. Horiuchi, M. Matsumoto, M. Nakamura
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: - Issue: 5 Pages: 1334-1345
- DOI
  10.1002/jor.23787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-15K10420
[Journal Article] Inhibition of MMP-2-mediated cellular invasion by NF-kappa B inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis.2017
- Author(s)
  T. Ukaji, Y. Lin, S. Okada and K. Umezawa
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 485 Pages: 76-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice.2017
- Author(s)
  X. Jiang, B. Wei, Y. Lan, C. Dai, Y. Gu, J. Ma, X. Liu, K. Umezawa and Y. Zhang
- Journal Title
  
  Immunopharmacology and Immunotoxicology
  
  Volume: 39:3 Pages: 157-164
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice2017
- Author(s)
  X. Jiang, B. Wei, Y. Lan, C. Dai, Y. Gu, J. Ma, X. Liu, K. Umezawa and Y. Zhang
- Journal Title
  
  Immunopharmacology and Immunotoxicology 39: 157-164, 2017
  
  Volume: 39 Pages: 157-164
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Molecular design of sugar-free migracin analog migracinal that inhibits ovarian cancer cell migration and invasion.2017
- Author(s)
  T. Ukaji, N. Koide, Y. Lin, K. Banno, S. Gantsev and K. Umezawa
- Journal Title
  
  Creative Surgery and Oncology
  
  Volume: 7 (4) Pages: 16-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Journal Article] The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation.2016
- Author(s)
  Okamoto T, Ozawa Y, Kamoshita M, Osada H, Toda E, Kurihara T, Nagai N, Umezawa K, Tsubota K
- Journal Title
  
  PLoS One
  
  Volume: 11(1) Issue: 1 Pages: 1-14
- DOI
  10.1371/journal.pone.0146517
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10881, KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-15K10903, KAKENHI-PROJECT-16K20329
[Journal Article] Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.2016
- Author(s)
  M. El-Salhy and K. Umezawa
- Journal Title
  
  International J. Molecular Medicine
  
  Volume: 37 Issue: 3 Pages: 556-564
- DOI
  10.3892/ijmm.2016.2481
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Angiopoietin-like protein 2 is a multistep regulator of inflammatory neovascularization in a murine model of age-related macular degeneration2016
- Author(s)
  M. Hirasawa, K. Takubo, H. Osada, S. Miyake, E. Toda, M. Endo, K. Umezawa, K. Tsubota, Y. Oike and Y. Ozawa
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Pages: 7373-7385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Effects of AP-1 and NF-kappa B inhibitors on colonic endocrine cells in rats with TNBS-induced colitis2016
- Author(s)
  M. El-Salhy and K. Umezawa
- Journal Title
  
  Molecular Medicine Reports 14: 1515-1522, 2016
  
  Volume: 14 Pages: 1515-1522
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Design and synthesis of 15-deoxyspergualin-biotin conjugates as novel binding probes for target protein screening.2016
- Author(s)
  M. Morioka, K. Kato, and K. Umezawa
- Journal Title
  
  J. Antibiotics
  
  Volume: in press Issue: 7 Pages: 574-578
- DOI
  10.1038/ja.2016.32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Angiopoietin-like protein 2 is a multistep regulator of inflammatory neovascularization in a murine model of age-related macular degeneration.2016
- Author(s)
  M. Hirasawa, K. Takubo, H. Osada, S. Miyake, E. Toda, M. Endo, K. Umezawa, K. Tsubota, Y. Oike and Y. Ozawa
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 14 Pages: 7373-7385
- DOI
  10.1074/jbc.m115.710186
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-25461192, KAKENHI-PROJECT-25462734, KAKENHI-PUBLICLY-15H01520, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-15K10903, KAKENHI-PROJECT-26670405
[Journal Article] Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis2016
- Author(s)
  M. El-Salhy, T. Mazzawi, K. Umezawa and O. H. Jilja
- Journal Title
  
  International J. Mol. Med.
  
  Volume: - Issue: 6 Pages: 1743-1751
- DOI
  10.3892/ijmm.2016.2787
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] A novel anti-inflammatory agent, DTCM-glutarimide, ameliorates murine models of inflammatory bowel disease.2016
- Author(s)
  N. Ichikawa, K. Yamashita, T. Funakoshi, S. Ichihara, M. Fukai, M. Ogura, N. Kobayashi, M. Zaitsu, T. Yoshida, S. Shibasaki, Y. Koshizuka, Y. Tsunetoshi, M. Sato, T. Einama, M. Ozaki, K. Umezawa, T. Suzuki and S. Todo
- Journal Title
  
  Inflammation Research
  
  Volume: 65 Issue: 3 Pages: 245-260
- DOI
  10.1007/s00011-015-0911-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Inhibition of NF-κB activity enhances sensitivity to anticancer drugs in cholangiocarcinoma cells.2016
- Author(s)
  W. Seubwai, K. Vaeteewoottacharn, R. Kraiklang, K. Umezawa, S. Okada and S. Wongkham
- Journal Title
  
  Oncology Research
  
  Volume: 23 Issue: 1 Pages: 21-28
- DOI
  10.3727/096504015x14424348426071
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Inhibition of NF-κB and cellular invasion by novel flavonoid desmal in ovarian carcinoma cells.2016
- Author(s)
  L. Wang, Y. Lin, K. Sidthipong, J. Tang, M. Li, T. Koyano, T. Kowithayakorn, K. Sumiyoshi, T. Ukaji, and K. Umezawa
- Journal Title
  
  Heterocycles
  
  Volume: 92 Issue: 2 Pages: 353-360
- DOI
  10.3987/com-15-13386
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Anti-inflammatory effects of novel AP-1 and NF-κB inhibitors in dextran-sulfate-sodium-induced colitis in rats.2016
- Author(s)
  M. El-Salhy and K. Umezawa
- Journal Title
  
  International J. Mol. Med.
  
  Volume: in press Issue: 6 Pages: 1457-1464
- DOI
  10.3892/ijmm.2016.2560
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Inhibition of NF-κB with dehydroxyepoxiquinomicin modifies function of human peritoneal mesothelial cells2016
- Author(s)
  P. Sosinska, B. Mackowiak, R. Staniszewski, K. Umezawa and A. Breborowicz
- Journal Title
  
  American Journal of Translational Research
  
  Volume: 8 Pages: 5756-5765
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Inhibition of NF-κB activity enhances sensitivity to anticancer drugs in cholangiocarcinoma cells2016
- Author(s)
  W. Seubwai, K. Vaeteewoottacharn, R. Kraiklang, K. Umezawa, S. Okada and S. Wongkham
- Journal Title
  
  Oncology Research
  
  Volume: 23 Pages: 21-28
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Inhibition of nuclear factor-κB signaling suppresses Spint-1-deletion-induced tumor susceptibility in the ApcMin/+ mode2016
- Author(s)
  M. Kawaguchi, K. Yamamoto, A. Kanemaru, H. Tanaka, K. Umezawa, T. Fukushima, H. Kataoka
- Journal Title
  
  Oncotarget 7 (42): 68614-68622, 2016
  
  Volume: 7 Pages: 68614-68622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Inhibition of NF-κB and cellular invasion by novel flavonoid desmal in ovarian carcinoma cells2016
- Author(s)
  L. Wang, Y. Lin, K. Sidthipong, J. Tang, M. Li, T. Koyano, T. Kowithayakorn, K. Sumiyoshi, T. Ukaji, and K. Umezawa
- Journal Title
  
  Heterocycles
  
  Volume: 92 Pages: 353-360
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.2016
- Author(s)
  S. Katsuyama, K. Sugino, Y. Sasazawa, Y. Nakano, H. Aono, K. Morishita, M. Kawatani, K. Umezawa, H. Osada and S. Simizu
- Journal Title
  
  FEBS Letters
  
  Volume: 590 Issue: 8 Pages: 1152-1162
- DOI
  10.1002/1873-3468.12146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-26750373, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16J40133, KAKENHI-PROJECT-16K01941
[Journal Article] nhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide2015
- Author(s)
  N. Koide, A. Kaneda, T. Yokochi, K. Umezawa
- Journal Title
  
  International Immunopharmacology
  
  Volume: VOL. 25 Pages: 162-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and Hodgkin lymphoma cell lines.2015
- Author(s)
  T. Toda, M. Watanabe, J. Kawato, M. Higashihara, T. Kunisada, K. Umezawa and R. Horie
- Journal Title
  
  British J. Haematology
  
  Volume: 170 Issue: 6 Pages: 837-846
- DOI
  10.1111/bjh.13508
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-26460439, KAKENHI-PROJECT-26460440
[Journal Article] Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells2015
- Author(s)
  Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.
- Journal Title
  
  Int. Arch. Allergy Immunol.
  
  Volume: 166 Pages: 84-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2015
- Author(s)
  Matsui C, Ikeda Y, Iinuma H, Kushida N, Kunisada T, Simizu S, Umezawa K.
- Journal Title
  
  J. Antibiot.
  
  Volume: 67 Issue: 11 Pages: 787-790
- DOI
  10.1038/ja.2014.63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] Inhibition of IGF-1-mediated cellular migration and invasion by migracin A in ovarian clear cell carcinoma cells.2015
- Author(s)
  T. Ukaji, Y. Lin, K. Banno, S. Okada and K. Umezawa
- Journal Title
  
  PLOS One
  
  Volume: 10 Issue: 9 Pages: e0137663-e0137663
- DOI
  10.1371/journal.pone.0137663
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor–κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts2015
- Author(s)
  S. Inokawa, T. Watanabe, H. Keino, Y. Sato, A. Hirakata, A. A. Okada, K. Fukuda, A. Fukushima, K. Umezawa
- Journal Title
  
  Graefes Arch. Clin. Exp. Ophthalmol.
  
  Volume: VOL. 253 Pages: 557-563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] 3-[(dodecylthiocarbonyl)methyl]-glutarimide attenuates graft arterial disease by suppressing alloimmune responses and vascular smooth muscle cell proliferation.2015
- Author(s)
  M. Zaitsu, K. Yamashita, S. Shibasaki, Y. Tsunetoshi, M. Fukai, M. Ogura, T. Yoshida, R. Igarashi, N. Kobayashi, K. Umezawa and S. Todo
- Journal Title
  
  Transplantation
  
  Volume: 99 Pages: 948-956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] A nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates GVHD in allogeneic bone marrow transplantation.2015
- Author(s)
  S. Yamanouchi, Y. Adachi, T. Shimo, K. Umezawa, M. Okigaki, S. Tsuji, M Li, J. Takaya, T. Kuge, S. Ikehara, K. Kaneko
- Journal Title
  
  Immunobiology
  
  Volume: 220 Issue: 9 Pages: 1059-1066
- DOI
  10.1016/j.imbio.2015.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy2015
- Author(s)
  Sasazawa Y, Sato N, Umezawa K, Simizu S.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 10 Pages: 6168-6178
- DOI
  10.1074/jbc.m114.606293
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
[Journal Article] Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism2015
- Author(s)
  Kuboki M, Ito A, Simizu S, Umezawa K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 456 Issue: 3 Pages: 810-814
- DOI
  10.1016/j.bbrc.2014.12.024
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mTOR-independent autophagy2015
- Author(s)
  Y. Sasazawa, N. Sato, K. Umezawa, S. Simizu
- Journal Title
  
  J. Biol Chem.
  
  Volume: VOL. 290 Pages: 6168-6178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: Involvement of positive feedback mechanism2015
- Author(s)
  M. Kuboki, A. Ito, S. Simizu, K. Umezawa
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: VOL. 456 Pages: 810-814
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Inhibition of canonical NF-κB nuclear localization by (-)-DHMEQ via impairment of DNA binding2015
- Author(s)
  K. Horie, J. Ma, K. Umezawa
- Journal Title
  
  Oncology Research
  
  Volume: VOL. 22 Pages: 105-115
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer.2015
- Author(s)
  Y. Ito, E. Kikuchi, N. Tanaka, T. Kosaki, E. Suzuki, R. Mizuno, T. Shinojima, A. Miyajima, K. Umezawa and M. Oya
- Journal Title
  
  BMC Cancer
  
  Volume: 15 Issue: 1 Pages: 324-324
- DOI
  10.1186/s12885-015-1315-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-26462429, KAKENHI-PROJECT-26750362
[Journal Article] Inhibition of MMP-2-mediated mast cell invasion by NF-κB inhibitor DHMEQ in mast cells2015
- Author(s)
  N. Noma, M. Asagiri, M. Takeiri, S. Ohmae, K. Takemoto, K. Iwaisako, S. Simizu, K. Umezawa
- Journal Title
  
  International Achieves of Allergy and Immunology
  
  Volume: VOL. 166 Pages: 84-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] DSE-FRET: A new anti-cancer drug screening assay for DNA binding proteins2014
- Author(s)
  T. Miyagi, B. Shiotani, R. Miyoshi, T. Yamamoto, T. Oka, K. Umezawa, T. Ochiya, M. Takano and H. Tahara
- Journal Title
  
  Cancer Science
  
  Volume: VOL. 105 Pages: 870-874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells2014
- Author(s)
  T. Togano, M. Watanabe, K. Itoh, K. Umezawa, N. Masuda, M. Higashihara, R. Horie
- Journal Title
  
  Lung Cancer
  
  Volume: VOL. 83 Pages: 139-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor, (-)-DHMEQ2014
- Author(s)
  M. Sato, K. Nakanishi, S. Haga, M. Fujiyoshi, M. Baba, K. Mino, Yimin, H. Niwa, H. Yokoo, K. Umezawa, Y. Ohmiya, T. Kamiyama, S. Todo, A. Taketomi, M. Ozaki
- Journal Title
  
  Oncology Research
  
  Volume: VOL. 21 Pages: 333-343
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation2014
- Author(s)
  M. Kamoshita, Y. Ozawa, S. Kubota, S. Miyake, C. Tsuda, N. Nagai, K. Yuki, S. Shimmura, K. Umezawa and K. Tsubota
- Journal Title
  
  PLOS One
  
  Volume: VOL.9 Pages: 1-10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Involvement of conserved tryptophan residues for secretion of TIMP-22014
- Author(s)
  Ukaji, T., Sasazawa, Y., Umezawa, K. & Simizu, S.
- Journal Title
  
  Oncology Letters
  
  Volume: 7 Pages: 631-634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167
[Journal Article] Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells2014
- Author(s)
  M. Watanabe, K. Umezawa, M. Higashihara, R. Horie
- Journal Title
  
  Oncology Research
  
  Volume: VOL. 21 Pages: 173-180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2014
- Author(s)
  C. Matsui, Y. Ikeda, H. Iinuma, N. Kushida, T. Kunisada, S. Simizu and K. Umezawa
- Journal Title
  
  J. Antibiotics
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] C-mannosylation of human hyaluronidase 1: Possible roles for secretion and enzymatic activity.2014
- Author(s)
  Goto, Y., Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S.
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 45 Issue: 1 Pages: 344-350
- DOI
  10.3892/ijo.2014.2438
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167
[Journal Article] The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma2014
- Author(s)
  M. Celegato, C. Borghese, K. Umezawa, N. Casagrande, A. Colombatti, A. Carbone, D. Aldinucci
- Journal Title
  
  Cancer Letters
  
  Volume: VOL. 349 Pages: 26-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Immunosuppression through constitutively activated NF-κB signaling in human ovarian cancer and its reversal by a NF-κB inhibitor2014
- Author(s)
  H. Nishio, T. Yaguchi, J. Sugiyama, H. Sumimoto, K. Umezawa, T. Iwata, N. Susumu, T.Fujii, N. Kawamura, A. Kobayashi, J-H Park, D. Aoki, Y. Kawakami
- Journal Title
  
  British J. Cancer
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Poly (ADP-Ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells.2014
- Author(s)
  N. Lampiasi, K.Umezawa, G. Montalto, M. Cervello
- Journal Title
  
  BBA-Molecular Cell Research
  
  Volume: VOL. 1843 Pages: 2662-2673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2014
- Author(s)
  C. Matsui, Y. Ikeda, H. Iinuma, N. Kushida, T. Kunisada, S. Simizu, K. Umezawa
- Journal Title
  
  Journal of Antibiotics
  
  Volume: VOL. 67 Pages: 787-790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells2014
- Author(s)
  M. Watanabe, K. Umezawa, M. Higashihara and R. Horie
- Journal Title
  
  Oncology Res.
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Amelioration of severe TNBS induced colitis by novel AP-1 and NF-κB inhibitors in rats.2014
- Author(s)
  M. El-Salhy, K. Umezawa, O.-H. Gilja, J. G. Hatlebakk, D. Gundersen, T. Hausken
- Journal Title
  
  The Scientific World
  
  Volume: VOL. 2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells2014
- Author(s)
  T. Togano, M. Watanabe, K. Itoh, K. Umezawa, N. Masuda, M. Higashihara and R. Horie
- Journal Title
  
  Lung Cancer
  
  Volume: 83 Pages: 139-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma2014
- Author(s)
  M. Celegato, C. Borghese, K. Umezawa, N. Casagrande, A. Colombatti, A. Carbone, and D. Aldinucci
- Journal Title
  
  Cancer Letters
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy2014
- Author(s)
  W. Seubwai, R. Kraiklang, K. Vaeteewoottacharn, K. Umezawa, S. Okada, S. Wongkham
- Journal Title
  
  PLOS One
  
  Volume: VOL.9 Pages: 1-10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Immunosuppression through constitutively activated NF-κB signaling in human ovarian cancer and its reversal by a NF-κB inhibitor2014
- Author(s)
  H. Nishio, T. Yaguchi, J. Sugiyama, H. Sumimoto, K. Umezawa, T. Iwata, N. Susumu, T.Fujii, N. Kawamura, A. Kobayashi, J-H Park, D. Aoki, Y. Kawakami
- Journal Title
  
  British Journal of Cancer
  
  Volume: VOL. 110 Pages: 2965-2974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Novel approaches to target NF-κB and other signaling pathways in cancer stem cells2014
- Author(s)
  T. Ukaji, K. Umezawa
- Journal Title
  
  Advances in Biological Regulation
  
  Volume: VOL. 56 Pages: 108-115
- Data Source
  KAKENHI-PROJECT-26350975
[Journal Article] Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor, (-)-DHMEQ2014
- Author(s)
  M. Sato, K. Nakanishi, S. Haga, M. Fujiyoshi, M. Baba, K. Mino, Yimin, H. Niwa, H. Yokoo, K. Umezawa, Y. Ohmiya, T. Kamiyama, S. Todo, A. Taketomi and M. Ozaki
- Journal Title
  
  Oncology Res.
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway2013
- Author(s)
  A. Ogasawara, S. Simizu, A. Ito, T. Kawai, Y. Saisho, I. Takei and K. Umezawa
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 433 Pages: 181-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of Cancer cell invasion and metastasis by NF-kappa B inhibitors2013
- Author(s)
  T. Ukaji, S. Gantsev and K. Umezawa
- Journal Title
  
  Creative Surgery and Oncology 2013 (3)
  
  Volume: 3 Pages: 6-12
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Combined effect of dehydroxymethylepoxyquinomicin and gemcitabine in a mouse model of liver metastasis of pancreatic cancer2013
- Author(s)
  K. Suzuki, K. Aiura, S. Matsuda, O. Itano, O. Takeuchi, K. Umezawa, and Y. Kitagawa
- Journal Title
  
  Clinical & Experimental Metastasis
  
  Volume: 30 Pages: 381-392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013
- Author(s)
  Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
- Journal Title
  
  J. Antibiot
  
  Volume: 66 Pages: 225-230
- NAID
  10031168683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline2013
- Author(s)
  Kuroda, M., Funasaki, S., Saitoh, T., Sasazawa, Y., Nishiyama, S., Umezawa, K. & Simizu, S.
- Journal Title
  
  FEBS Letters
  
  Volume: 587 Issue: 22 Pages: 3656-3660
- DOI
  10.1016/j.febslet.2013.09.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-24810025
[Journal Article] p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein2013
- Author(s)
  T. Ohsugi, T. Ishida, T. Shimasaki, S. Okada and K. Umezawa
- Journal Title
  
  Carcinogenesis
  
  Volume: 34 Pages: 2129-2136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] The efficacy of DHMEQ, a NF- κ B inhibitor , in islet transplantation : II. Induction DHMEQ treatment ameliorates subsequent allo-immune responses, and permits a long-term islet allograft acceptance2013
- Author(s)
  Watanabe M, Y amashita K, Kamachi H, Kuraya D, Koshizuka Y, Shibasaki S, Asahi Y, Ono H, Emoto S, Ogura M, Y oshida T, Ozaki M, Umezawa K, Matsushita M, T odo S
- Journal Title
  
  Transplantation
  
  Volume: 96(5) Issue: 5 Pages: 454-62
- DOI
  10.1097/tp.0b013e31829b077f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390309
[Journal Article] Peritoneal NF-κB as a possible molecular target for suppression of various cancers and inflammation. (Review)2013
- Author(s)
  K. Umezawa
- Journal Title
  
  Forum of Immunopathological Diseases and Therapeutics
  
  Volume: 4 Pages: 63-77
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013
- Author(s)
  Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
- Journal Title
  
  J. Antibiot.
  
  Volume: 66
- NAID
  10031168683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of cancer cell invasion and metastasis by NF-kappa B inhibitors. (Review)2013
- Author(s)
  T. Ukaji, S. Gantsev and K. Umezawa
- Journal Title
  
  Creative Surgery and Oncology
  
  Volume: 3 Pages: 6-12
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] The efficacy of DHMEQ, a NF- κ B inhibitor , in islet transplantation : I. HMGB1 suppression by DHMEQ prevents early islet graft damage2013
- Author(s)
  Kuraya D, Watanabe M, Koshizuka Y, Ogura M, Y oshida T, Asahi Y, Kamachi H, Nakamura T, Harashima H, Ozaki M, Umezawa K, Matsushita M, Y amashita K, T odo S
- Journal Title
  
  Transplantation
  
  Volume: 96(5) Issue: 5 Pages: 445-53
- DOI
  10.1097/tp.0b013e31829b0744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390309
[Journal Article] Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF- κB suppression via reactive oxygen species and unfolded protein response2013
- Author(s)
  S. Nakajima, H. Kato, L. Gu, S. Takahashi, H. Johno, K. Umezawa and M. Kitamura
- Journal Title
  
  J. Immunol.
  
  Volume: 190 Pages: 6559-6569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Synergistic effect of 5-azacytidine and NF-kappa B inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells2013
- Author(s)
  T. Togano, M. Nakashima, M. Watanabe, K. Umezawa, T. Watanabe, M. Higashihara and R. Horie
- Journal Title
  
  Oncology Res.
  
  Volume: 20 Pages: 571-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] The novel NF-κB inhibitor DHMEQ synergizes with Celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism2012
- Author(s)
  N. Lampiasi, A. Azzolina1, K Umezawa, G. Montalto, J. A. McCubrey and M. Cervello
- Journal Title
  
  Cancer Lett.
  
  Volume: 322 Pages: 35-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of cellular invasion and induction of anoikis in mouse melanoma cells by an anti-inflammatory agent DTCM-glutarimide2012
- Author(s)
  A. Kaneda, S. K. Gantsev and K. Umezawa
- Journal Title
  
  Creative Surgery and Oncology
  
  Volume: 2012 Pages: 4-9
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via NFκB pathway on advanced-stage epithelial ovarian cancer2012
- Author(s)
  C. Alberti, P. Pinciroli, B. Valeri, R. Ferri, A. Ditto, K. Umezawa, M. L. Sensi, S. Canevari, and A. Tomassetti
- Journal Title
  
  Oncogene
  
  Volume: 31 Pages: 4139-4149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Novel approaches to target cancer initiating cells-Eliminating the root of the cancer2012
- Author(s)
  J.A.McCubrey, K.Umezawa, et al
- Journal Title
  
  Advances in Enzyme Regulation
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] The immunomodulatory effect of nuclear factor-κB inhibition by dehydroxymethylepoxyquinomicin in combination with donor-specific blood transfusion2012
- Author(s)
  R.Goto, K.Umezawa, M.Ozaki, et al
- Journal Title
  
  Transplantation
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of nuclear factor-jB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells2012
- Author(s)
  A.M.Castro-Gamero, K.Umezawa, et al
- Journal Title
  
  Anti-Cancer Drugs
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by proinflammatory cytokines derived from RAW 264.7 macrophage cells2012
- Author(s)
  M.Kawata, K.Umezawa, et al
- Journal Title
  
  J.Biochem.
  
  Volume: (in press)
- NAID
  10031166059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012
- Author(s)
  T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
- Journal Title
  
  FEBS Lett.
  
  Volume: 586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice.2012
- Author(s)
  T.Funakoshi, M.Ozaki, K.Umezawa, et al
- Journal Title
  
  Journal of Crohn's and Colotis
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012
- Author(s)
  M.Takeiri, K.Umezawa, et al
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 10 Pages: 3053-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of cellular invasion and induction of anoikis in mouse melanoma cells by an anti-inflammatory agent DTCM-glutarimide2012
- Author(s)
  A. Kaneda, S. K. Gantsev and K. Umezawa
- Journal Title
  
  Creative Surgery and Oncology 2012
  
  Pages: 4-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Determination of the absolute structure of (+)-akaterpin2012
- Author(s)
  H.Hosoi, K.Umezawa, et al
- Journal Title
  
  Chem.Pharm.Bull.
  
  Volume: 60 Pages: 137-143
- NAID
  130001852337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012
- Author(s)
  T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
- Journal Title
  
  FEBS Lett
  
  Volume: 586 Pages: 1504-1509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by proinflammatory cytokines derived from RAW 264.7 macrophage cells2012
- Author(s)
  M. Kawata, D. Koinuma, T. Ogami, K. Umezawa, C. Iwata, T. Watabe and K. Miyazono
- Journal Title
  
  J. Biochem.
  
  Volume: 151 Pages: 205-216
- NAID
  10031166059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced brest cancer cell adhesion2012
- Author(s)
  Noma, N., Simizu, S., Kambayashi, Y., Kabe, Y., Suematsu, M. & Umezawa, K
- Journal Title
  
  Oncology Reports
  
  Volume: 27 Pages: 2080-2084
- DOI
  10.3892/or.2012.1733
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23310163
[Journal Article] Antitumor effect of dehydroxymethylepoxyquinomicin (DHMEQ), a small molecule inhibitor of nuclear factor-κB, on glioblastoma2012
- Author(s)
  T.Fukushima, K.Umezawa, et al
- Journal Title
  
  Neuro-Oncology
  
  Volume: 14 Pages: 19-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012
- Author(s)
  M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
- Journal Title
  
  Org. Biomol. Chem
  
  Volume: 10 Pages: 3053-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Suppression of inflammatory cytokine secretion by an NF-κB inhibitor in nasal polyps fibroblasts2012
- Author(s)
  F. C.P. Valera, K. Umezawa, M. S. Brassesco, A. M. C. Gamero, R. G. P. Queiro, C. A. Scrideli, L. G. Tone, W. T. Anselmo-Lima
- Journal Title
  
  Cellular Physiology and Biochemistry
  
  Volume: 30 Pages: 13-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats2012
- Author(s)
  R.Saito, K.Umezawa, et al
- Journal Title
  
  Endocrinology
  
  Volume: 153 Pages: 621-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] A chemo-enzymatic expeditious route to racemic dihexanoyl (2R*,3R*,4R*)-dehydroxymethylepoxyquinomycin (DHMEQ), the precursor for lipase-catalyzed synthesis of the potent NF-κB Inhibitor, (2S,3S,4S)-DHMEQ2012
- Author(s)
  R. Kobayashi, K. Hanaya, M. Shoji, K. Umezawa and T. Sugai
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Pages: 1220-1223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Structure-activity relationship Of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012
- Author(s)
  M.Takeiri, S.Simizu, K.Umezawa, et al
- Journal Title
  
  Oncology Res.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer2012
- Author(s)
  K. Hinohara, S. Kobayashi, S. Simizu, K. Tada, E. Tsuji, K. Nishioka, K. Umezawa, M. Mori, H. Kanauchi, T. Ogawa, J. Inoue, A. T and N. Gotoh
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 109 Pages: 6584-6589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced breast cancer cell adhesion2012
- Author(s)
  N. Noma, S. Simizu, Y. Kambayashi, Y. Kabe, M. Suematsu, and K. Umezawa
- Journal Title
  
  Oncology Reports
  
  Volume: 27 Pages: 2080-2084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012
- Author(s)
  M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 3053-3059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Structure-activity relationship of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012
- Author(s)
  M. Takeiri, E. Ota, S. Nishiyama, H. Kiyota, S. Simizu and K. Umezawa
- Journal Title
  
  Oncology Res.
  
  Volume: 20 Pages: 7-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Enhancement of radiosensitivity by a unique novel NF-κB inhibitor, DHMEQ, in prostate cancer2012
- Author(s)
  N. Kozakai, E. Kikuchi, M. Hasegawa, E. Suzuki, H. Ide, A. Miyajima, Y. Horiguchi, J. Nakashima, K. Umezawa, N. Shigematsu and M. Oya
- Journal Title
  
  British J. Cancer
  
  Volume: 107 Pages: 652-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells2012
- Author(s)
  A. M. Castro-Gamero, K. S. Borgesa, V. da Silva Silveira, R. C. P. Lira, R. de Paula G. Queiroz, F. C. P. Valera, C. A. Scrideli, K. Umezawa and L. G. Tone
- Journal Title
  
  Anti-Cancer Drugs
  
  Volume: 2012 Pages: 638-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] ErbB/NFkB signaling controls self-renewal of breast cancer stem cells2012
- Author(s)
  K.Hinohara, K.Umezawa, et al
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Suppression of inflammatory cytokine secretion by an NF-κB inhibitor in nasal polyps fibroblasts2012
- Author(s)
  F.C.P.Valera, K.Umezawa, et al
- Journal Title
  
  Cellular Physiology and Biochemistry
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] The novel NF-kB inhibitor DHMEQ synergizes with Celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism2012
- Author(s)
  N.Lampiasi, K Umezawa, et al
- Journal Title
  
  Cancer Lett.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice2012
- Author(s)
  T. Funakoshi, K. Yamashita, N. Ichikawa, M. Fukai, T. Suzuki, R. Goto, T. Oura, N. Kobayashi, T. Katsurada, S. Ichihara, M. Ozaki, K. Umezawa, and Satoru Todo
- Journal Title
  
  Journal of Crohn’s and Colotis
  
  Volume: 5 Pages: 215-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via NFκB pathway on advanced-stage epithelial ovarian cancer2012
- Author(s)
  C.Alberti, K.Umezawa, et al
- Journal Title
  
  Oncogene
  
  Volume: (in press) Issue: 37 Pages: 4139-4149
- DOI
  10.1038/onc.2011.572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] 新しいNF-κB阻害剤DHMEQの生物有機化学と抗炎症・抗がん剤への展望2011
- Author(s)
  梅澤一夫、須貝威
- Journal Title
  
  化学と生物
  
  Volume: 49 Pages: 406-414
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Chemoenzymatic synthesis of (2R,3R,4R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf22011
- Author(s)
  Y.Niitsu, K.Umezawa, et al
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 9 Pages: 4635-4641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway2011
- Author(s)
  K.Kobayashi, K.Umezawa, et al
- Journal Title
  
  Biology of Reproduction
  
  Volume: 84 Pages: 248-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Possible role of peritoneal NF-κB in peripheral inflammation and cancer : Lessons from the inhibitor DHMEQ2011
- Author(s)
  K.Umezawa
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 65 Pages: 252-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Synthesis and biological evaluation of molecular probes based on the 9-methylstr eptimidone derivative DTCM-glutarimide2011
- Author(s)
  E.Ota, K.Umezawa, et al
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 22 Pages: 164-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion2011
- Author(s)
  K.Mino, M.Ozaki, K.Umezawa, et al
- Journal Title
  
  Cancer Science 102 : 1052-1058
  
  Volume: 102 Pages: 1052-1058
- NAID
  10029293761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion2011
- Author(s)
  K. Mino, M. Ozaki, K. Nakanishi, S. Haga, M. Sato, M. Kina, M. Takahashi, N. Takahashi, A. Kataoka, K. Yanagihara, T. Ochiya, T. Kamiyama, K. Umezawa and S. Todo
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 1052-1058
- NAID
  10029293761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Synthesis and determination of the relative structure of akaterpin, a potent inhibit or of PI-PLC2011
- Author(s)
  H.Hosoi, K.Umezawa, et al
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52 Pages: 4961-4964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components., 20112011
- Author(s)
  T.Saitoh, K.Umezawa, et al
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 21 Pages: 6293-6296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] 新しいNF-κB阻害剤DHMEQの生物有機化学と抗炎症・抗がん剤への展望2011
- Author(s)
  須貝威、梅澤一夫
- Journal Title
  
  化学と生物
  
  Volume: (掲載確定)
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Role of NF-κB/Snail/RKIP loop in the response of tumor cells to photodynamic therapy2011
- Author(s)
  V.Rapozzi, K.Umezawa, et al
- Journal Title
  
  Lasers in Surgery and Medicine 2011
  
  Volume: 43 Pages: 575-585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Suppression of erosive arthritis by NF-κB Inhibitors2011
- Author(s)
  T.Kubota, K.Umezawa
- Journal Title
  
  Current Rheumatology Reviews
  
  Volume: 7 Pages: 275-281
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α2011
- Author(s)
  K.Tsumura, K.Umezawa, et al
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 9 Pages: 6357-6366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Placenta growth factor induces melanoma resistance to temozolomide through a mechanism that involves the activation of the transcription factor NF-κB2011
- Author(s)
  L.Levati, K.Umezawa, et al
- Journal Title
  
  International J.Oncol.
  
  Volume: 38 Pages: 241-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone2011
- Author(s)
  M.Takeiri, M.Ozaki, K.Umezawa, et al
- Journal Title
  
  Inflammation Research
  
  Volume: 60 Pages: 879-888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Coffee induces breast cancer resistance protein expression in Caco-2 cells2011
- Author(s)
  M.Isshiki, K.Umezawa, et al
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 34 Pages: 1624-1627
- NAID
  130001086598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] Possible role of peritoneal NF-κB in peripheral inflammation and cancer : Lessons from the inhibitor DHMEQ.2011
- Author(s)
  K.Umezawa
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Regulation of human dendritic cells by a novel specific nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin.2010
- Author(s)
  K.Shinoda, K.Umezawa, et al
- Journal Title
  
  Human Immunology
  
  Volume: 71 Pages: 763-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Efficient cellular uptake of the novel NF-κB inhibitor (-)-DHMEQ and irreversible inhibition of NF-κB in neoplastic cells2010
- Author(s)
  C.Shimada, K.Umezawa, et al
- Journal Title
  
  Oncology Research
  
  Volume: 18 Pages: 529-535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Characterizing the involvement of the nuclear factor-kappa B (NFκB) transcription factor in uveal melanoma.2010
- Author(s)
  R.Dror, K.Umezawa, et al
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: 58 Pages: 1811-1816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Donor pretreatment with DHMEQ improves islet transplantation.2010
- Author(s)
  T.Takahashi, K.Umezawa, et al
- Journal Title
  
  Journal of Surgical Research
  
  Volume: 163 Pages: 23-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion.2010
- Author(s)
  N.Miyanishi, K.Banno, K.Umezawa, et al
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 403 Pages: 154-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Nuclear factor-κB inhibitor, dehydroxy methyl epoxyquinomicin ameliorates experimental autoimmune uveoreitnitis(EAU)in mice2010
- Author(s)
  D.Iwata, K.Umezawa, et al
- Journal Title
  
  Investigative Ophthalmology & Visual Science 51
  
  Pages: 2077-2084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Potent cytotoxic effect of a novel nuclear factor-kappa B inhibitor on human bladder cancer cells producing various cytokines.2010
- Author(s)
  K.Kodaira, K.Umezawa, et al
- Journal Title
  
  Urology
  
  Volume: 75 Pages: 805-812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells2010
- Author(s)
  M.Murohashi, K.Umezawa, et al
- Journal Title
  
  British J.Cancer 102
  
  Pages: 206-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Topical application of DHMEQ improves allergic inflammation via NF-κB inhibition.2010
- Author(s)
  A.Hamasaka, K.Umezawa, et al
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 126 Pages: 400-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] A novel NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.2010
- Author(s)
  T.Saitoh, K.Umezawa, et al
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 20 Pages: 5638-5642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Dehydroxyquinomicin inhibits expression and production of inflammatory mediators in interleukin-1β-induced human chondrocytes.2010
- Author(s)
  V.Cardile, K.Umezawa, et al
- Journal Title
  
  Cellular Physiology and Biochemistry
  
  Volume: 25 Pages: 543-550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Dehydroxyquinomicin, a novel NF-kappaB inhibitor, prevents inflammatory injury induced by IFN-γ and histamine in keratinocytes NCTC 2544.2010
- Author(s)
  V.Cardile, K.Umezawa, et al
- Journal Title
  
  Cellular and Experimental Pharmacology and Physiology
  
  Volume: 37 Pages: 679-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Design, synthesis, and biological evaluation of novel estradiol-bisp hosphonate conjugates as bone-specific estrogens2010
- Author(s)
  M.Morioka, K.Umezawa, et al
- Journal Title
  
  Bioorg.Med.Chem. 11
  
  Pages: 1143-1148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Chemoenzymatic synthesis of (2S,3S,4S)-form2010
- Author(s)
  M. Hamada, Y. Niitsu, C. Hiraoka, I. Kozawa, T. Higashi, M. Shoji, K. Umezawa, T. Sugai
- Journal Title
  
  the physiologically active stereoisomer of dehydroxymethylepoxyquinomicin (DHMEQ), a potent inhibitor on NF-κB. Tetrahedron 66
  
  Pages: 7083-7087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Chemoenzymatic synthesis of (2S,3S,4S)-form, the physiologically active stereoisomer of dehydroxymethylepoxyquinomicin (DHMEQ), a potent inhibitor on NF-κB.2010
- Author(s)
  M.Hamada, T.Sugai, K.Umezawa, et al
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 7083-7087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Promotion of β-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells2010
- Author(s)
  M.Kawakami, K.Umezawa, et al
- Journal Title
  
  Biomedicine & Pharmacotherapy 64
  
  Pages: 226-231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Inhibition of active HIV-1 replication by NF-κB inhibitor DHMEQ.2010
- Author(s)
  A.Miyake, K.Umezawa, et al
- Journal Title
  
  Microbes and Infection
  
  Volume: 12 Pages: 400-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion.2010
- Author(s)
  N. Miyanishi, Y. Suzuki, S. Simizu, Y. Kuwabara, K. Banno. K. Umezawa
- Journal Title
  
  Biochem.Biophys.Res.Commun. 403
  
  Pages: 154-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Unusual intramolecular N→O acyl group migration occurring during conjugation of(-)-DHMEQ with cysteine2009
- Author(s)
  I.Kozawa, K.Umezawa, et al
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 5380-5382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome. An attractive target for the NF-κB-specific inhibitor DHMEQ.2009
- Author(s)
  Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N, Umezawa K.
- Journal Title
  
  Ann N Y Acad Sci 1173
  
  Pages: 137-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591165
[Journal Article] Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor (-)-DHMEQ.2009
- Author(s)
  E. Suzuki, Y. Ninomiya, K. Umezawa
- Journal Title
  
  Biochem.Biophys.Res.Commun. 379
  
  Pages: 379-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Inhibition of inflammatory mediator secretion by(-)-DHMEQ in mouse bone marrow-derived macrophages2009
- Author(s)
  E.Suzuki, K.Umezawa, et al
- Journal Title
  
  Biomed.Pharmacother 63
  
  Pages: 351-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Possible involvement of chemokine-induced platelet activation in throm bophilic diathesis of antiphospholipid syndrome : an attractive target for the NF-kB-specific inhibitor DHMEQ.2009
- Author(s)
  T. Kubota, K. Umezawa, et al
- Journal Title
  
  Ann. N. Y. Acad. Sci. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.2009
- Author(s)
  J. Inumaru, K. Umezawa, et al
- Journal Title
  
  Genes Cells 14(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Antitumor effects of DHMEQ, a novel NF-κB inhibitor, in human liver cancer cells is mediated through a reactive oxygen species-dependent mechanism2009
- Author(s)
  N.Lampiasi, K.Umezawa, et al
- Journal Title
  
  Molecular Pharmacology 76
  
  Pages: 290-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Unusual intramolecular N>O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine.2009
- Author(s)
  I. Kozawa, K. Kato, T. Teruya, K. Suenaga, K. Umezawa
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 5380-5382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome.An attractive target for the NF-κB-specific inhibitor DHMEQ.2009
- Author(s)
  Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N, Umezawa K.
- Journal Title
  
  Ann N Y Acad Sci 1173巻
  
  Pages: 137-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591165
[Journal Article] Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor(-)-DHMEQ2009
- Author(s)
  E.Suzuki, K.Umezawa, et al
- Journal Title
  
  Biochem.Biophys.Res.Commun 379
  
  Pages: 379-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Transient inhibition of NF-κB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation2009
- Author(s)
  N.Dabaghmanesh, K.Umezawa, et al
- Journal Title
  
  Cancer Science 100
  
  Pages: 737-746
- NAID
  10025144771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Synthesis and biological evaluation on novel analogs of 9-methyl-streptimidone, an inhibitor of NF-κB.Bioorg2009
- Author(s)
  Y.Ishikawa, K.Umezawa, et al
- Journal Title
  
  Med.Chem.Lett 19
  
  Pages: 1726-1728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Efficient synthesis of(±)-parasitenone, a novel inhibitor of NF-κB.2009
- Author(s)
  T.Saitoh, K.Umezawa, et al
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 5383-5386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Enzyme-catalyzed resolution of 3, 8-dioxatricyclo[3.2.1.02, 4]octane-6-carboxylic esters and the application to the synthesis of 3-epishikimic acid.2009
- Author(s)
  M.Hamada, K.Umezawa, et al
- Journal Title
  
  Tetrahedron : Asymmetry 20
  
  Pages: 2105-2111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Induction of oncogene addiction shift to NF-κB by camptothecin in solid tumor cells2009
- Author(s)
  T.Togano, K.Umezawa, et al
- Journal Title
  
  Biochem.Biophys.Res.Commun. 390
  
  Pages: 60-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Antidiabetic effect of plant extract containing conophylline by oral administration in streptozotocin-treated and Goto-Kakizaki rats2009
- Author(s)
  M.Fujii, K.Umezawa, et al
- Journal Title
  
  Biomedicine &.Pharmacotherapy 63
  
  Pages: 710-716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells2009
- Author(s)
  N.Tsukamoto, K.Umezawa, et al
- Journal Title
  
  Clin.Cancer Res. 15
  
  Pages: 5733-5743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress2009
- Author(s)
  J.Inumaru, K.Umezawa, et al
- Journal Title
  
  Genes Cells 14
  
  Pages: 706-716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Preparation of conophylline affinity nanobeads and identification of a target protein2009
- Author(s)
  E.Suzuki, K.Umezawa, et al
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 6185-6195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Target-selective degradation of cancer-related proteins by novel photosensitizers for molecular-targeted photodynamic therapy2009
- Author(s)
  K.Toshima, K.Umezawa, et al
- Journal Title
  
  (Review article)Cancer Science 100
  
  Pages: 1581-1584
- NAID
  10027194039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.2008
- Author(s)
  S. Baritaki, K. Umezawa, et al
- Journal Title
  
  J. Immunol. 180
  
  Pages: 6199-6210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues.2008
- Author(s)
  M. Yamamoto, K. Umezawa, et al
- Journal Title
  
  J. Med. Chem. 51
  
  Pages: 5780-5788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] The NF-κB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs.2008
- Author(s)
  M. I. Vega, K. Umezawa, et al
- Journal Title
  
  Leukemia and Lymphoma 49
  
  Pages: 1982-1994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] The novel NF-kB inhibitor, Dehydroxymethylepoxyquinomi-cin (DHMEQ) prevents local and remote organ injury following intestinal ischemia/ reperfusion in rats2008
- Author(s)
  Tomomi Suzuki, Hiroyuki Furukawa, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo et. al.
- Journal Title
  
  Journal of Surgical Research 149
  
  Pages: 69-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209041
[Journal Article] NF-κBを標的とする抗癌剤2008
- Author(s)
  鈴木絵里子、梅澤一夫
- Journal Title
  
  医学のあゆみ 244
  
  Pages: 65-69
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Effects of DHMEQ, a novel nuclear factor-kB inhibitor on beta cell dysfunction in INS cells.2008
- Author(s)
  Y. Saisho, K. Umezawa, et al
- Journal Title
  
  Endocrine J. 55
  
  Pages: 433-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Identification of the RelA domain responsible for action of a new NF-kB inhibitor DHMEQ.2008
- Author(s)
  M. Watanabe, K. Umezawa, et al
- Journal Title
  
  Biochem. Biophys. Res. Commun. 376
  
  Pages: 310-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues.2008
- Author(s)
  M. Yamamoto, R. Horie, M. Takeiri, I. Kozawa, K. Umezawa
- Journal Title
  
  J.Med.Chem. 51
  
  Pages: 5780-5788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells.2008
- Author(s)
  C. Nishioka, K. Umezawa, et al
- Journal Title
  
  Immunology 124
  
  Pages: 198-205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts.2008
- Author(s)
  S. Makino, K. Umezawa, et al
- Journal Title
  
  J. Dermatol. Sci. 51
  
  Pages: 171-180
- NAID
  10024298393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.2008
- Author(s)
  Z. Meng, K. Umezawa, et al
- Journal Title
  
  Endocrinology 149
  
  Pages: 5357-5365
- NAID
  120006982281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] The novel NF-kB activation inhibitor dehydroxymethyl-epoxyquinomicin suppresses anti-Thyl. 1-induced glomerulonephritis in rats.2008
- Author(s)
  T. Kosaka, K. Umezawa, et al
- Journal Title
  
  Nephron Exp. Nephrol. 110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kB inhibitor, Dehydroxymethylepoxyquinomicin (DHMEQ).2008
- Author(s)
  K. Horiuchi, K. Umezawa, et al
- Journal Title
  
  Cancer Letters 272
  
  Pages: 336-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kB inhibitor DHMEQ.2008
- Author(s)
  A. Miyake, K. Umezawa, et al
- Journal Title
  
  Microbes and Infection 10
  
  Pages: 748-756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] The novel NF-kappa B inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reper fusion in rats.2008
- Author(s)
  T. Suzuki, K. Umezawa, et al
- Journal Title
  
  J. Surg. Res. 149
  
  Pages: 69-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Inhibition of tumor angiogenesis by targeting endotheliai ATP synthase with sangivamycin.2007
- Author(s)
  Y. Komi, K. Umezawa, et al.
- Journal Title
  
  Japan Journal of Clinical Oncology 37
  
  Pages: 867-873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines : Involvement in chemosensitization to drug-induced apoptosis2007
- Author(s)
  E. Suzuki, K. Umezawa, et al.
- Journal Title
  
  Oncogene 26
  
  Pages: 6184-6189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] IκBα independent induction of NF-κB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells.2007
- Author(s)
  M. Watanabe, K. Umezawa, et al.
- Journal Title
  
  Laboratory Investigation 87
  
  Pages: 372-382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Conophylline and betacellulin-δ4 : an effective combination of differentiation factors for pancreatic β cells.2007
- Author(s)
  R. Kitamura, K. Umezawa, et al.
- Journal Title
  
  Endocline J 54
  
  Pages: 255-264
- NAID
  10019478673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Reversal of resistance to cytotoxic cancer therapies : DHMEQ as a chemo-sensitizing and immuno-sensitizing agent.2007
- Author(s)
  A. Katsman, K. Umezawa, et al.
- Journal Title
  
  Drug Resistance Updates 10
  
  Pages: 1-12
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] NF-κB inhibitorDHMEQ suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANCL, OPG or M-CSF.2007
- Author(s)
  T. Kubota, K. Umezawa, et al.
- Journal Title
  
  Arthritis Research & Therapy 9/5/R97(Open Access)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Targeting NF-κB and induction of apoptosis by novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells.2007
- Author(s)
  N. Kimura, K. Umezawa, et al.
- Journal Title
  
  Leukemia Research 31
  
  Pages: 6184-6189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Tyrosine kinase inhibitor methyl-2,5-dihydroxycinnamate induces PML nuclear body formation and apoptosis in tumor cells.2007
- Author(s)
  N. Komura K. Umezawa, et al.
- Journal Title
  
  Exp. Cell Res. 313
  
  Pages: 2753-2765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor.2007
- Author(s)
  N. Komura, K. Umezawa, et al.
- Journal Title
  
  Leuk. Res. 31
  
  Pages: 301-313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin2007
- Author(s)
  Shinya Ueki, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo et. al.
- Journal Title
  
  Transplantation 82(12)
  
  Pages: 1720-1727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209041
[Journal Article] 炎症を抑制する生理活性物質の探索2007
- Author(s)
  梅澤一夫
- Journal Title
  
  蛋白質核酸酵素 52, No.13
  
  Pages: 1685-1689
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia-derived cell lines.2007
- Author(s)
  T. Ohsugi, K. Umezawa, et al.
- Journal Title
  
  Cancer Letters 257
  
  Pages: 206-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.2007
- Author(s)
  Y. N. Kimura, K. Umezawa, et al.
- Journal Title
  
  Cancer Science 98
  
  Pages: 2009-2018
- NAID
  10019996850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor.2007
- Author(s)
  N.Komura, K.Umezawa, et al.
- Journal Title
  
  Leuk. Res. 31
  
  Pages: 301-313
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Suppression of diabetes-induced retinal inflammation by blocking angiotensin II type 1 receptor or its downstream NF-κB pathway.2007
- Author(s)
  N. Nagai, K. Umezawa, et al.
- Journal Title
  
  Investigative Ohthalmology and Visual Science 48
  
  Pages: 4342-4350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Inhibition of NF kappa B activation by 9-methylstreptimidone isolated from Streptomyces.2006
- Author(s)
  Z.Wang, K.Umezawa, et al.
- Journal Title
  
  Heterocycles 69
  
  Pages: 377-383
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Control of allograft rejection by applying a novel NF-kB inhibitor, dehydroxymethylepoxyquinomicin.2006
- Author(s)
  Shinya Ueki, Kenichiro Yamashita, Takeshi Aoyagi, Sanae Haga, Tomomi Suzuki, Tomoo Itoh, Masahiko Taniguchi, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
- Journal Title
  
  Transplantation 82・12
  
  Pages: 1720-1727
- Data Source
  KAKENHI-PROJECT-18209041
[Journal Article] Inhibition of Tipopolysaccharide activity by a bacterial cyclic lipopeptide surfactin.2006
- Author(s)
  T.Takahashi, K.Umezawa, et al.
- Journal Title
  
  J. Antibiot 59
  
  Pages: 35-43
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Conophylline : A novel differentiation inducer for pancreatic β cells.2006
- Author(s)
  I.Kojima, K.Umezawa
- Journal Title
  
  Int. J. Biochem. 38
  
  Pages: 923-930
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Survivin associates with cell proliferation in renal cancer cells : Regulation of surviving expression by insulin-like growth factor-1, interferon-γ and a novel NF-κB inhibitor.2006
- Author(s)
  A.Sato, K.Umezawa, et al.
- Journal Title
  
  Int. J. Oncology 28
  
  Pages: 841-846
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Inhibition of tumor growth by NF-κB inhibitors.2006
- Author(s)
  K.Umezawa
- Journal Title
  
  Cancer Science 97
  
  Pages: 990-995
- NAID
  10019377732
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] BRAFV600E promotes invasiveness of thyroid cancer cells through NF-κB activation.2006
- Author(s)
  I.Palona, K.Umezawa, et al.
- Journal Title
  
  Endocrinology 147
  
  Pages: 5699-5707
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Effects of a novel NF-κB inhibitor, dehydroxymethyepoxyquinomicin (DHMEQ), on growth, apoptosis gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines.2006
- Author(s)
  H.Ruan, K.Umezawa, et al.
- Journal Title
  
  Leukemia 20
  
  Pages: 800-806
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Inhibition of Lipopolysaccharide Activity a Bacterial Cyclic Lipopeptide Surfactin2006
- Author(s)
  Taichi Takahashi, Osamu Ohno, Yoko Ikeda, Ryuichi Sawa, Yoshiko Homma, Masayuki Igarashi, Kazuo Umezawa
- Journal Title
  
  The Journal of Antibiotics 59・1
  
  Pages: 35-43
- NAID
  10017147139
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510187
[Journal Article] ケミカルパソロシーによる病態解析と薬剤開発。2006
- Author(s)
  梅澤一夫
- Journal Title
  
  現代化学2006年7月号 No.424
  
  Pages: 38-42
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Blocking NF-κB as a potential strategy to treat adult T-cell leukemia/lymphoma.2006
- Author(s)
  R.Horie, K.Umezawa, et al.
- Journal Title
  
  Drug News Persrect. 19
  
  Pages: 201-209
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Inhibition of Lipopolysaccharide Activity by a Bacterial Cyclic Lipopeptide Surfactin2006
- Author(s)
  T.Takahashi, O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, K.Umezawa
- Journal Title
  
  The Journal of Antibiotics 59・1
  
  Pages: 35-43
- NAID
  10017147139
- Data Source
  KAKENHI-PROJECT-15510187
[Journal Article] In vitro and in vivo antitumor activity of the NF-kappa B inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.2006
- Author(s)
  T.Ohsugi, K.Umezawa, et al.
- Journal Title
  
  Leuk. Res. 30
  
  Pages: 90-97
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] DHMEQ, a new NF-κB inhibitor, induces apoptosis and enhances fludarabine effects on chronic lymphocytic leukemia cells.2006
- Author(s)
  R.Horie, K.Umezawa, et al.
- Journal Title
  
  Leukemia 20
  
  Pages: 800-806
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] 転写因子NF-κBと癌の進展。2006
- Author(s)
  梅澤一夫
- Journal Title
  
  バイオサイエンスとインダストリー 64 (No.4)
  
  Pages: 224-225
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Inhibition of macrophage activation and phagocytosis by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin.2006
- Author(s)
  E.Suzuki, K.Umezawa
- Journal Title
  
  Biomed. Pharmacother. 60
  
  Pages: 578-586
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethylepoxyquinonicin.2006
- Author(s)
  S.Ueki, K.Umezawa, et al.
- Journal Title
  
  Transplantation 82
  
  Pages: 1720-1727
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Adrenaline contributes to prenatal respiratory maturation in rat medulla-spinal cord preparation.2006
- Author(s)
  M.Fujii, K.Umezawa, et al.
- Journal Title
  
  Brain Res. 1090
  
  Pages: 45-50
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.2005
- Author(s)
  Kuroda K, Horiguchi Y, Nakashima J, Kikuchi E, Kanao K, Miyajima A, Ohigashi T, Umezawa K, Murai M
- Journal Title
  
  Clin. Cancer Res. 11
  
  Pages: 5590-5594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390469
[Journal Article] Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis.2005
- Author(s)
  C.Culmsee, K.Umezawa, et al.
- Journal Title
  
  Molecular Pharmacology 68
  
  Pages: 1006-1017
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Targeting of NF-κB pathways by DHMEQ, a novel inhibitor of breast carcinomas : Anti-tumor and anti-angiogenic activity in vivo2005
- Author(s)
  G.Matsumoto, J.Namekawa, M.Muta, T.Nakamura, H.Bando, K.Tohyama, M.Toi, K.Umezawa
- Journal Title
  
  Clin.Cancer Res. 11
  
  Pages: 1287-1293
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Dopamine desynchronizes the pace-making neuronal zctivity of rat respiratory rhythm generation.2005
- Author(s)
  M.Fujii, K.Umezawa, et al.
- Journal Title
  
  Eur. J. Neurosci. 23
  
  Pages: 1015-1027
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] A novel NF-κB inhibitor DHMEQ selectively targets constitutive NF-κB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo2005
- Author(s)
  M.Watanabe, M.Z.Dewan, T.Okamura, M.Sasaki, K.Itoh, M.Higashihara, H.Mizoguchi, M.Honda, T.Sata, T.Watanabe, N.Yamamoto, K.Umezawa, R.Horie
- Journal Title
  
  Int.J.Cancer 114
  
  Pages: 32-38
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Dopaminergic effects on respiratory rhythm generation in rat brainstem-spinal cord preparation2005
- Author(s)
  M.Fujii, K.Umezawa, A.Arata
- Journal Title
  
  Neuroscience Res. 50
  
  Pages: 355-359
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.2005
- Author(s)
  Kuroda K, Horiguchi Y, Nakashima J, Kikuchi E, Kanao K, Miyajima A, Ohigashi T, Umezawa K, Murai M
- Journal Title
  
  Clin. Cancer Res. 11(15)
  
  Pages: 5590-5594
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390469
[Journal Article] Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc12005
- Author(s)
  H.Takatsuna, M.Asagiri, T.Kubota, K.Oka, T.Osada, C.Sugiyama, H.Saito, K.Aoki, K.Ohya, H.Takayanagi, K.Umezawa
- Journal Title
  
  J.Bone Mineral Res. 20
  
  Pages: 653-661
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Synergistic antiviral effect of oxanosine and ddI against human immunodeficiency virus2005
- Author(s)
  M.Nakamura, T.Ogawa, A.Yokono, S.Nakamori, T.Ohno, K.Umezawa
- Journal Title
  
  Biomed.Pharmacother. 59
  
  Pages: 47-50
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.2005
- Author(s)
  Kuroda K, Horiguchi Y, Nakashima J, Kikuchi E, Kanao K, Miyajima A, Ohigashi T, Umezawa K, Murai M.
- Journal Title
  
  Clin. Cancer Res 11
  
  Pages: 5590-5594
- Data Source
  KAKENHI-PROJECT-16390469
[Journal Article] Diabetes mellitus : rational basis, clinical approach and future therapy2004
- Author(s)
  H.Ohgawara, K.Edamura, M.Kawakami, K.Umezawa
- Journal Title
  
  Biomed.Pharmacother. 58
  
  Pages: 605-609
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Isolation of Heptadepsin, a Novel Bacterial Cyclic Depsipeptide that inhibits Lipopolysaccharide Activity2004
- Author(s)
  O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, N.Kinoshita, Y.Suzuki, K.Miyake, K.Umezawa
- Journal Title
  
  Chemistry & Biology 17-11
  
  Pages: 1059-1070
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510187
[Journal Article] Screening of bioactive metabolites for pancreatic regeneration chemotherapy2004
- Author(s)
  H.Takatsuna, K.Umezawa
- Journal Title
  
  Biomed.Pharmacother. 58
  
  Pages: 610-613
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Genistein and daizein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs2004
- Author(s)
  M.Murata, K.Midorikawa, M.Koh, K.Umezawa, S.Kawanishi
- Journal Title
  
  Biochemistry 43
  
  Pages: 2569-2577
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, DHMEQ2004
- Author(s)
  D.V.Starenki, H.Namba, V.A.Saenko, A.Ohtsuru, S.Maeda, K.Umezawa, S.Yamashita
- Journal Title
  
  Clin.Cancer Res. 10
  
  Pages: 6821-6829
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Isolation of Heptadepsin, a Nobel Bacterial Cyclic Depsipeptide that inhibits Lipopolysaccharide Activity2004
- Author(s)
  O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, N.Kinoshita, Y.Suzuki, K.Miyake, K.Umezawa
- Journal Title
  
  Chemistry & Biology 17・11
  
  Pages: 1059-1070
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510187
[Journal Article] Promotion of β cell differentiation by conophylline in fetal and neonatal rat pancreas2004
- Author(s)
  T.Ogata, L.Li, S.Yamada, Y.Yamamoto, Y.Tanaka, I.Takei, K.Umezawa, I.Kojima
- Journal Title
  
  Diabetes 53
  
  Pages: 2596-2602
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Isolation of Heptadepsin, a Nobel Bacterial Cyclic Depsipeptide that inhibits Lipopolysaccharide Activity2004
- Author(s)
  O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, Y.Suzuki,...K.Umezawa
- Journal Title
  
  Chemistry & Biology 11
  
  Pages: 1059-1070
- Data Source
  KAKENHI-PROJECT-15510187
[Journal Article] Isolation of heptadepsin, a novel bacterial cyclic depsipeptide that inhibits lipopolysaccharide activity2004
- Author(s)
  O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, N.Kinoshita, Y.Suzuki, K.Miyake, K.Umezawa
- Journal Title
  
  Chemistry & Biology 11
  
  Pages: 1059-1070
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor (-)-DHMEQ.
- Author(s)
  E. Suzuki, K. Umezawa, et al
- Journal Title
  
  Biochem. Biophys. Res. Commun. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611015
[Journal Article] Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-κB inhibitor
- Author(s)
  H.Takatsuna, S.Morita, T.Nagatsu, M.Sawada, K.Umezawa
- Journal Title
  
  Biomed.Pharmacother. (印刷中)
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] The novel NF-kB inhibitor, Dehydroxymethylepoxyquinomicin(DHMEQ)prevents local and remote organ injury following intestinal ischemia/reperfusion in rats.
- Author(s)
  Tomomi Suzuki, Kenichiro Yamashita, Wataru Jomen, Shinya Ueki, Takeshi Aoyagi, Moto Fukai, Hiroyuki Furukawa, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo
- Journal Title
  
  J Surg Res (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209041
[Journal Article] Reversal of drug resistance by COTC based on intracellular glutathione and glyoxalase
- Author(s)
  D.Kamiya, Y.Uchihata, E.Ichikawa, K.Kato, K.Umezawa
- Journal Title
  
  Biorg.Med.Chem.Lett. (印刷中)
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Inhibition of cellular adhesion in human umbilical vein endothelial cells by NF-κB inhibitor DHMEQ under flow
- Author(s)
  O.Ohno, Y.Shima, Y.Ikeda, Y.Kawai, K.Sakurai, K.Watanabe, K.Umezawa
- Journal Title
  
  Oncology Res. (印刷中)
- Data Source
  KAKENHI-PROJECT-16073217
[Journal Article] Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor
- Author(s)
  M. Sato, K. Nakanishi, S. Haga, M. Fujiyoshi, M. Baba, K. Mino, Yimin, H. Niwa, H. Yokoo, K. Umezawa, Y. Ohmiya, T. Kamiyama, S. Todo, A. Taketomi and M. Ozaki
- Journal Title
  
  Oncology Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310163
[Journal Article] 新しいNF-κB阻害剤DHMEQの生物有機化学と抗炎症・抗がん剤への展望
- Author(s)
  須貝威、梅澤一夫
- Journal Title
  
  化学と生物 (印刷中)
- Data Source
  KAKENHI-PROJECT-20611015
[Patent] 外用組成物の生産方法2018
- Inventor(s)
  梅澤一夫、小出悠紀子
- Industrial Property Rights Holder
  ブルネエズ株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2020
- Data Source
  KAKENHI-PROJECT-17K01967
[Patent] マクロライド化合物の毒性のない抗炎症剤・抗転移剤としての新規用途2017
- Inventor(s)
  梅澤一夫、林音知
- Industrial Property Rights Holder
  愛知医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-193428
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K01967
[Patent] Nrf2活性化剤2010
- Inventor(s)
  梅澤一夫、袴田雅俊、後藤侑子
- Industrial Property Rights Holder
  慶應義塾
- Industrial Property Number
  2010-230930
- Filing Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20611015
[Patent] Nrf2活性化剤2010
- Inventor(s)
  梅澤一夫、袴田雅俊、後藤優子
- Industrial Property Rights Holder
  慶應義塾
- Industrial Property Number
  2010-230930
- Filing Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-20611015
[Patent] 医薬組成物2008
- Inventor(s)
  梅澤一夫, ほか3名
- Industrial Property Rights Holder
  慶應義塾
- Industrial Property Number
  2008-166290
- Filing Date
  2008-06-25
- Data Source
  KAKENHI-PROJECT-20611015
[Patent] 抗腫瘍剤に対する腫瘍細胞の感受性増強剤2006
- Inventor(s)
  梅澤一夫他3名
- Industrial Property Rights Holder
  慶應義塾
- Industrial Property Number
  2006-274257
- Filing Date
  2006-10-05
- Data Source
  KAKENHI-PROJECT-16073217
[Patent] NF-κBを阻害する抗炎症、抗癌剤2006
- Inventor(s)
  梅澤一夫ほか
- Industrial Property Rights Holder
  慶應義塾
- Industrial Property Number
  2006-000902
- Filing Date
  2006-01-05
- Data Source
  KAKENHI-PROJECT-16073217
[Presentation] メチオニンを添加したカビ培養液からの新規LPS機能阻害物質myceliostatinの単離2023
- Author(s)
  Lin Yinzhi, Wu Yanhua, Wang Liyan, 小嶋しおり, 小出直樹, 梅澤一夫
- Organizer
  第96回日本細菌学会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] Inhibition of in vivo human colorectal carcinoma cell growth by conophylline and knockout of molecular target ARL6ip12023
- Author(s)
  Lin Y, Ito H, Umezawa K
- Organizer
  第27回がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] クマザサ葉抽出物の抗炎症・抗酸化活性と介護用品・化粧品への応用2023
- Author(s)
  小嶋しおり，袴田雅俊，梅澤一夫
- Organizer
  第25回日本褥瘡学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] オオシマザクラ葉抽出物の抗炎症活性と介護用品への応用2023
- Author(s)
  袴田雅俊，小嶋しおり，梅澤一夫
- Organizer
  第25回日本褥瘡学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] Conophylline-target ARL6ip1 regulates Ran-mediated cellular migration and invasion in human colorectal cancer cells2023
- Author(s)
  Lin Y, Karnan S, Ito H, Umezawa K
- Organizer
  AACR Annual Meeting 2023
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] AH-337 is a novel bile acid derivative designed to inhibit HBV entry2023
- Author(s)
  Okumura A, Yamashita Y, Iguchi Y, Yokogawa M, Ohashi H, Arai J, Umezawa K, Ikeda K, Osawa M, Watashi K, Wakita T, Une M, Ito K
- Organizer
  2023 International HBV Meeting
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] ノブドウ果実に含まれるε-viniferinの抗炎症活性とヒト子宮内膜症細胞遊走・浸潤抑制作用2023
- Author(s)
  小嶋しおり，馬俊，若槻明彦，梅澤一夫
- Organizer
  日本生薬学会第69回年会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] ノブドウに含まれるε-viniferin によるヒト子宮内膜症細胞の遊走・浸潤抑制2023
- Author(s)
  小嶋しおり，Lin Yinzhi，袴田雅俊，武内恒成，若槻明彦，梅澤一夫
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] カビMyceliophthora thermophileメチオニン添加培養からの新規抗炎症物質myceliostatinの単離2022
- Author(s)
  Wu Yanhua，Lin Yinzhi，小嶋しおり，梅澤一夫
- Organizer
  第16回日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] Bile acid derivative INT-767 interacts with the preS1 of HBsAg2022
- Author(s)
  Okumura A, Yokogawa M, Yamashita Y, Iguchi Y, Ohashi H, Une M, Umezawa K, Watashi K, Wakita T, Yoneda M, Osawa M, Ito K
- Organizer
  2022 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] メチオニン添加培養した微生物からの新規エンドトキシン機能阻害物質の単離・構造決定2022
- Author(s)
  Wu Yanhua，Lin Yinzhi，小嶋しおり，梅澤一夫
- Organizer
  第68回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] クマザサ抽出物の抗炎症活性および抗酸化活性と含有成分の解析2022
- Author(s)
  小嶋しおり，袴田雅俊，浅沼俊倫，梅澤一夫
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] クマササ含有成分および誘導体によるLPSに誘導される炎症反応の抑制2020
- Author(s)
  林音知、深津仁見、小嶋しおり、梅澤一夫、小出直樹
- Organizer
  第93回日本細菌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] 新しいI-κB kinase β阻害剤ketomycinによる乳がん細胞の遊走・浸潤およびヒト臍帯静脈内皮細胞管腔形成の抑制。2019
- Author(s)
  Lin Yinzhi、小嶋しおり、梅澤一夫
- Organizer
  第23回がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] 深海カビAspergillusが産生するcyclopeninによる炎症誘起因子発現の抑制とハエ学習障害モデルの改善。2019
- Author(s)
  林音知、王立岩、Wu Yanhua、小出直樹、梅澤一夫
- Organizer
  新規素材探索研究会第18回セミナー
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫の細胞浸潤抑制と抗がん剤感受性の増強。2019
- Author(s)
  Lin Yinzhi、小出直樹、梅澤一夫
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Role of peritoneal NF-κB on cancer and inflammation2019
- Author(s)
  Kazuo Umezawa
- Organizer
  Medical Forum in Shymkent, Kazakhstan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] 新しいI-κB kinase β阻害剤ketomycinによる細胞の遊走・浸潤および炎症性サイトカイン産生の抑制。2019
- Author(s)
  Lin Yinzhi、杉浦信夫、小嶋しおり、小出直樹、梅澤一夫
- Organizer
  第14回日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] クマササ含有成分および誘導体によるLPS作用の阻害。2019
- Author(s)
  Lin Yinzhi、深津仁見、小嶋しおり、梅澤一夫、小出直樹
- Organizer
  第65回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Amelioration of metabolic syndrome and neurodegenerative disease models by plant-derived alkaloid conophylline2018
- Author(s)
  Kazuo Umezawa
- Organizer
  21st International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] がん細胞の遊走を阻害する放線菌由来ketomycinのスクリーニングと乳がんMDA-MB-231細胞における2Dおよび3D浸潤の抑制2018
- Author(s)
  Lin Yinzhi、梅澤一夫
- Organizer
  第22回がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Inhibition of titanium dioxide nanoparticle-induced inflammatory reaction by NF-κB inhibitor DHMEQ in human macrophage-like cells2018
- Author(s)
  Hitomi Fukatsu, Tamami Ukaji, Saeko Tada-Oikawa, Kiyora Izuoka, Yoshikazu Naiki, Takayuki Komatsu, Naoki Koide, Akihiko Ikegami, Sahoko Ichihara, Kazuo Umezawa
- Organizer
  21st International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Discovery, mechanism of action, and therapeutic activity of NF-kappa B inhibitor DHMEQ2018
- Author(s)
  Kazuo Umezawa
- Organizer
  Conference “Future of Oncology is Laid Today”（招待講演）（国際学会）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] 放線菌由来細胞遊走阻害剤ketomycinの単離と乳がん細胞におけるMMP依存性浸潤の抑制2018
- Author(s)
  Lin Yinzhi、Wu Yanhua、梅澤一夫
- Organizer
  第13回日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of 2D and 3D invasion of human breast carcinoma cells2018
- Author(s)
  Yinzhi Lin, Yanhua Wu, Kazuo Umezawa
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] 新規NF-κB阻害剤SEMBLによる骨肉腫細胞および線維肉腫細胞に対する抗腫瘍効果2018
- Author(s)
  松尾俊宏，梅澤一夫，松井卓哉，佐藤啓二，河南勝久，出家正隆
- Organizer
  第91回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] PM2.5モデルTiO2ナノ粒子に誘導されるマクロファージのIL-1 beta産生とNF-kappa B阻害剤DHMEQによる抑制2018
- Author(s)
  深津仁見、梅澤一夫、森田奈央子、内記良一、小松孝行、小出直樹
- Organizer
  新規素材探索研究会第17回セミナー
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫SP-2/0細胞のMMP-9およびMMP-13が関与する浸潤の抑制と抗がん剤感受性の増強2017
- Author(s)
  Sidthipong Kulrawee、宇梶珠未、梅澤一夫
- Organizer
  第21回がん分子標的治療学会2017.6.14-16
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Molecular design of sugar-free migracin analog migracinal that inhibits cancer cell migration and invasion2017
- Author(s)
  Tamami Ukaji, Yinzhi Lin, Naoki Koide, and Kazuo Umezawa
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるTiO2ナノ粒子に誘導されるマクロファージ炎症反応の抑制（若手奨励講演）2017
- Author(s)
  宇梶珠未、深津仁見、及川佐枝子、出岡淑、市原佐保子、梅澤一夫、小出直樹
- Organizer
  第64回トキシンシンポジウム
- Place of Presentation
  有馬、兵庫
- Year and Date
  2017-07-10
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of breast cancer cell migration and invasion2017
- Author(s)
  Yinzhi Lin and Kazuo Umezawa
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるナノ粒子誘導IL-1β産生の抑制2017
- Author(s)
  深津仁見、宇梶珠、及川佐枝、出岡、市原佐保、小出直樹、梅澤一夫
- Organizer
  第12回日本ケミカルバイオロジー学会 2017.6.7-9
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Inhibition of TiO2 nanoparticle-induced inflammatory reaction in macrophages by NF-κB inhibitor DHMEQ2017
- Author(s)
  Kazuo Umezawa, Hitomi Fukatsu, Tamami Ukaji and Naoki Koide
- Organizer
  13th Keio-Yonsei Joint Symposium（招待講演）（国際学会）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] NF-κB阻害剤DHMEQによるTiO2ナノ粒子に誘導されるマクロファージ炎症反応の抑制2017
- Author(s)
  宇梶珠未、深津仁見、及川佐枝子、出岡淑、市原佐保子、梅澤一夫、小出直樹
- Organizer
  第64回トキシンシンポジウム（若手奨励講演）
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] migracin脱糖アルデヒド体migracinalによる卵巣がん細胞遊走・浸潤の抑制2017
- Author(s)
  宇梶珠未、林音知、梅澤一夫
- Organizer
  第21回がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K01967
[Presentation] Inhibition of MMP-mediated 3D breast cancer cell invasion by NF-κB inhibitor DHMEQ. （口演）2016
- Author(s)
  Tamami Ukaji and Kazuo Umezawa
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜、神奈川
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 微生物由来migracin AによるIGF-1発現抑制を介した卵巣がん細胞遊走・浸潤の阻害2016
- Author(s)
  宇梶珠未、Lin Yinzhi、梅澤一夫
- Organizer
  第11回日本ケミカルバイオロジー学会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Inhibition of MMP-2-mediated cellular invasion by NF-κB inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis2016
- Author(s)
  Tamami Ukaji and Kazuo Umezawa
- Organizer
  12th Keio-Yonsei Joint Symposium 2016.10.21
- Place of Presentation
  横浜、神奈川
- Invited
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 微生物および植物由来LPS機能阻害物質の探索（若手奨励講演）2016
- Author(s)
  Sidthipong Kulrawee、小出直樹、梅澤一夫
- Organizer
  第63回トキシンシンポジウム
- Place of Presentation
  天童、山形
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Inhibition of IGF-1-mediated cellular migration and invasion by migracin A in ovarian clear cell carcinoma cells.2016
- Author(s)
  Tamami Ukaji and Kazuo Umezawa
- Organizer
  AACR-JCA 10th Joint Conference in Hawaii
- Place of Presentation
  Maui, USA.
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] NF-κB阻害剤DHMEQによる3Dがん細胞浸潤の抑制と機構解析2016
- Author(s)
  宇梶珠未、Lin Yinzhi、梅澤一夫
- Organizer
  第20回がん分子標的治療学会
- Place of Presentation
  別府、大分
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 放線菌由来細胞遊走・浸潤阻害物質migracinの単離と作用機構2016
- Author(s)
  Lin Yinzhi、宇梶珠未、梅澤一夫
- Organizer
  第15回新規素材研究会
- Place of Presentation
  新横浜、神奈川
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] NF-kappa B inhibitor, (-)-DHMEQ, as an anti-inflammatory agent in cosmetics.2015
- Author(s)
  Kulrawee Sidthipong and Kazuo Umezawa
- Organizer
  10th World Congress of the International Academy of Cosmetic Dermatology
- Place of Presentation
  Rio de Janeiro, Brazil.
- Year and Date
  2015-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Discovery and biological activity of epoxide-free DHMEQ analog: Compound of second generation.2015
- Author(s)
  Kulrawee Sidthipong, Susumu Kobayashi, Kazuo Umezawa
- Organizer
  BRICS Summit Satellite Symposium “Development of DHMEQ in BRICS countries”
- Place of Presentation
  Ufa, Russia.
- Year and Date
  2015-06-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 放線菌由来migracin Aによるvasohibin発現を介した卵巣がん細胞遊走の抑制。2015
- Author(s)
  宇梶珠未、林音知、梅澤一夫
- Organizer
  第19回がん分子標的治療学会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 放線菌由来新規がん細胞遊走阻害物質migracinの発見と卵巣がん細胞における遊走・浸潤抑制の作用機構。2015
- Author(s)
  宇梶珠未、Lin Yinzhi、梅澤一夫
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  横浜
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Inhibition of IGF-1 mediated cellular migration and invasion by migracin A in ovarian clear cell carcinoma cells.2015
- Author(s)
  Tamami Ukaji and Kazuo Umezawa
- Organizer
  European Gynecological Oncology Congress
- Place of Presentation
  Nice, France.
- Year and Date
  2015-10-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] LPS誘導性炎症反応を阻害する微生物生産物質の探索。2015
- Author(s)
  梅澤一夫、小出直樹
- Organizer
  第62回トキシンシンポジウム
- Place of Presentation
  伊勢志摩
- Year and Date
  2015-07-08
- Invited
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 卵巣がん細胞におけるmigracin AによるIGF-1発現および遊走・浸潤の抑制。Inhibition of IGF-1 mediated cellular migration and invasion by migracin A in ovarian carcinoma cells.2015
- Author(s)
  Tamami Ukaji and Kazuo Umezawa
- Organizer
  第74回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Discovery of DHMEQ and the role of peritoneal NF-kappa B on diseases.2015
- Author(s)
  Kazuo Umezawa
- Organizer
  BRICS Summit Satellite Symposium “Development of DHMEQ in BRICS countries”
- Place of Presentation
  Ufa, Russia.
- Year and Date
  2015-06-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Screening of signal transduction modulators that inhibit cancer cell growth and spread2014
- Author(s)
  Kazuo Umezawa
- Organizer
  DSK Mini-Symposium-Perspectives in Anticancer Drug Discovery and Development
- Place of Presentation
  Kyoto
- Year and Date
  2014-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 新規alkylglutarimide化合物による成人T細胞白血病細胞のNF-kappa B阻害と選択的アポトーシス誘導2013
- Author(s)
  宇梶　珠未、竹入　雅敏、伊藤あゆみ、清水史郎、梅澤一夫
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] NF-kappa B阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013
- Author(s)
  野間成人、清水史郎、梅澤一夫
- Organizer
  日本がん分子標的治療学会　第16回学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Suppression of NO-induced beta cell death by (-)-DHMEQ via activation of Nrf2-ARE pathway and alteration of MAPK activity2013
- Author(s)
  K. Umezawa, T. Ukaji, A. Ogasawara, S. Simizu and I. Takei
- Organizer
  49th Annual European Association for the Study of Diabetes (EASD) Meeting 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Neuroprotective effect of conophylline in cellular model of Parkinson’s disease2013
- Author(s)
  Yukiko Sasazawa, Kazuo Umezawa, Siro Simizu
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] 新規(-)-DHMEQ誘導体の分子デザインとサイトカイン分泌の抑制2013
- Author(s)
  Kulrawee Sidthipong、宇梶珠未、梅澤一夫
- Organizer
  第17回がん分子標的治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Induction of NF-kappa B and induction of selective apoptosis by novel alkylglutarimide compounds in adult T-cell leukemia cells2013
- Author(s)
  宇梶珠未、竹入雅敏、伊藤あゆみ、清水史郎、梅澤一夫
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] 新規 epoxide-free (-)-DHMEQ 誘導体の分子デザインとサイトカイン分泌の抑制2013
- Author(s)
  宇梶珠未、Kulrawee Sidthipong、小林進、梅澤一夫
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Conophyllineによるオートファジー誘導2013
- Author(s)
  笹澤有紀子、梅澤一夫、清水史郎
- Organizer
  日本ケミカルバイオロジー学会　第8回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] Anti-inflammatory and anticancer activities of novel NF-kappa B inhibitor DHMEQ2013
- Author(s)
  Kazuo Umezawa
- Organizer
  Eurasian Anticancer Conference
- Place of Presentation
  Ufa, Russia
- Invited
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Protection of β-cells from cell death by NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARF pathway2013
- Author(s)
  K. Umezawa and I. Takei
- Organizer
  The 18th World Congress on Advances in Oncology, and 16th International Symposium on Molecular Medicine
- Place of Presentation
  Crete, Greece
- Invited
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] conophyllineによる神経保護効果の解2013
- Author(s)
  笹澤有紀子、梅澤一夫、清水史郎
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] NF-κB阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013
- Author(s)
  野間成人、清水史郎、梅澤一夫
- Organizer
  第17回がん分子標的治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Molecular design of epoxide-free (-)-DHMEQ analog that inhibits NF-κB and cytokine secretions2013
- Author(s)
  K. Sidthipong, S. Kobayashi and K. Umezawa
- Organizer
  The 18th World Congress on Advances in Oncology, and 16th International Symposium on Molecular Medicine
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Molecular design of novel NF-kappa B inhibitors active on inflammation and cancer2013
- Author(s)
  Tamami Ukaji, Kulraweee Sidthipong, and Kazuo Umezawa
- Organizer
  The 2nd Official Conference of the International Chemical Biology Society (ICBS2013)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 炎症・癌を抑制するシグナル伝達阻害剤の探索と分子デザイン2012
- Author(s)
  梅澤一夫
- Organizer
  名古屋大学医学部グローバルCOE「第31回プログレスレポート会議」
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] DTCM-glutarimideによる成人T細胞白血病におけるRelBの分解とアポトーシス誘導2012
- Author(s)
  伊藤あゆみ，清水史郎、梅澤一夫
- Organizer
  日本癌学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] NF-κB阻害剤の発見と臨床への橋渡し研究。文科省がん支援・化学療法基盤支援活動2012
- Author(s)
  梅澤一夫
- Organizer
  第2回シンポジウム「アカデミアからの抗がん剤創薬へ向けて」
- Place of Presentation
  神奈川日吉(招待講演)
- Year and Date
  2012-02-22
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 糖尿病に有用なシグナル伝達阻害剤の探索と分子デザイン2012
- Author(s)
  梅澤一夫
- Organizer
  第18回日本糖尿病眼科学会総会。第27回日本糖尿病合併症学会。
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Inhibition of canonical and noncanonical NF-κBs by (-)-DHMEQ2012
- Author(s)
  K. Horie, K. Sidthipong, M. Takeiri, S. Simizu, and K. Umezawa
- Organizer
  The 17th World Congress on Advances in Oncology, and 15th International Symposium on Molecular Medicine
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Screening of cellular signaling inhibitors active on cancer and diabetes: Recent results2012
- Author(s)
  Kazuo Umezawa
- Organizer
  Forum of the Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University
- Place of Presentation
  Thailand
- Invited
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] (-)-DHMEQによるNF-kappa BのDNA結合および核局在の抑制2011
- Author(s)
  堀江佳奈、梅澤一夫, ほか
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Induction of apoptosis in adult T-cell leukemia cells by a novel PDK-1 inhibitor DTCM-glutarimide2011
- Author(s)
  Ayumi Ito, Kazuo Umezawa, et al
- Organizer
  The 16^<th> World Congress on Advances in Oncology, and 14^<th> International Symposium on Molecular Medicine
- Place of Presentation
  Rhodes, Greece
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 新規PDK1阻害剤DTCM-glutarimideによるマウス悪性黒色腫細胞の浸潤抑制およびアノイキス誘導。Inhibition of cellular invasion and induction of anoikis by a novel PDK1 inhibitor, DTCM-glutarimide, in mouse melanoma cells2011
- Author(s)
  兼田亜弓、梅澤一夫, ほか
- Organizer
  日本分子標的がん治療学会
- Place of Presentation
  東京
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 9-methylstreptimidone由来新規PDK-1阻害物質DTCM-glutarimideによるin vivo炎症反応の抑制2011
- Author(s)
  伊藤あゆみ、梅澤一夫, ほか
- Organizer
  天然有機化合物討論会
- Place of Presentation
  大阪
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 新規作用機構による(-)-DHMEQのnoncanonical NF-κB阻害2011
- Author(s)
  竹入雅敏、梅澤一夫, et al
- Organizer
  日本化学会
- Place of Presentation
  神奈川
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Galectin-3 binding proteinの作用と発現におけるNF-κBの関与。Regulation of Galectin-3 binding protein expression by NF-kappa B2011
- Author(s)
  野間成人、清水史郎、梅澤一夫
- Organizer
  日本分子標的がん治療学会
- Place of Presentation
  東京
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Screening from nature and molecular design of signal transduction inhibitors active on inflammation and cancer2011
- Author(s)
  Kazuo Umezawa
- Organizer
  14^<th> Asian Chemical Congress
- Place of Presentation
  Bangkok, Thailand(invited speaker)
- Year and Date
  2011-09-05
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Screening of NO production inhibitors in macrophages from microorganisms2011
- Author(s)
  Chino Matsui, Kazuo Umezawa, et al
- Organizer
  14^<th> Asian Chemical Congress
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2011-09-05
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Amelioration of atopic dermatitis model in mice by NF-κB inhibitor DHMEQ and its mechanism of action2011
- Author(s)
  K.Horie, K.Umezawa, et al
- Organizer
  BIT's 9^<th> Annual Congress of International Drug Discovery Science and Technology (IDDST)-2011
- Place of Presentation
  Shenzhen, China
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] (-)-DHMEQによるnoncanonical NF-kappa Bの新規阻害機構2011
- Author(s)
  竹入雅敏、清水史郎、梅澤一夫, ほか
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  神奈川
- Year and Date
  2011-05-23
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] カビ由来pyranopaxillineおよび類縁体によるマクロファージ活性の抑制2011
- Author(s)
  松井知野、梅澤一夫, ほか
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  神奈川
- Year and Date
  2011-05-23
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 新規PDK1阻害剤DTCM-glutarimideによるマウスメラノーマ細胞のアノイキス誘導および浸潤抑制2011
- Author(s)
  竹入雅敏、梅澤一夫, ほか
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Screening and molecular design of signal transduction inhibitors active on inflammation and cancer2011
- Author(s)
  Kazuo Umezawa
- Organizer
  BIT's 9^<th> Annual Congress of International Drug Discovery Science and Technology (IDDST)-2011
- Place of Presentation
  Shenzhen, China(invited speaker)
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] Role of peritoneal NF-κB on inflammation and cancer progression ; Lessons from the inhibitor DHMEQ2011
- Author(s)
  Kazuo Umezawa
- Organizer
  The 16^<th> World Congress on Advances in Oncology, and 14^<th> International Symposium on Molecular Medicine
- Place of Presentation
  Rhodes, Greece
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-23310163
[Presentation] 成人T細胞白血病MT-1細胞における(-)-DHMEQによるnoncanonical NF-κB活性化の抑制2010
- Author(s)
  竹入雅敏、梅澤一夫, et al
- Organizer
  日本がん分子標的治療学会
- Place of Presentation
  東京
- Year and Date
  2010-07-07
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] (-)-DHMEQによるnoncanonical NF-κB阻害の分子機構解析2010
- Author(s)
  竹入雅敏、梅澤一夫
- Organizer
  新規素材探索研究会
- Place of Presentation
  新横浜
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 高悪性度膀胱癌細胞の増殖・生存における転写因子AP-1およびNF-κBの関与2010
- Author(s)
  鈴木絵里子、梅澤一夫, et al
- Organizer
  日本がん分子標的治療学会
- Place of Presentation
  東京(口演)
- Year and Date
  2010-07-07
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 再生医療に有用な生理活性物質の探索と分子デザイン2010
- Author(s)
  梅澤一夫
- Organizer
  第4回ハイテク・リサーチ・センター・シンポジウム
- Place of Presentation
  日吉(招待講演)
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Discovery of novel AP-1 inhibitor DTCM-glutarimide and its anti-inflammatory and anti-metastatic activities. (Invited speaker)2010
- Author(s)
  兼田亜弓, 橘みゆき, 梅澤一夫
- Organizer
  29^<th> Congress of Egyptian Society of Nephrology & Transplantation
- Place of Presentation
  Cairo, Egypt
- Year and Date
  2010-03-03
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Structure-activity relationship of NF-κB inhibitor DHMEQ and preparation of soluble analog.2010
- Author(s)
  Chika Shimada, Kazuo Umezawa, et al
- Organizer
  The 15^<th> World Congress on Advances in Oncology, and 13^<th> International Symposium on Molecular Medicine
- Place of Presentation
  Loutraki, Greece
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] NF-κB阻害物質DHMEQ活性core分子のデザインと生物活性2010
- Author(s)
  嶋田知佳、鈴木絵里子、斉藤毅、石川裕一、西山繁、梅澤一夫
- Place of Presentation
  横浜
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] NF-κB阻害物質DHMEQ活性core分子のデザインと生物活性2010
- Author(s)
  嶋田知佳、梅澤一夫, et al
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  横浜
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Screening of bioactive metabolites active on tissue and cancer stem cells. (Invited speaker)2010
- Author(s)
  梅澤一夫
- Organizer
  29^<th> Congress of Egyptian Society of Nephrology & Transplantation
- Place of Presentation
  Cairo, Egypt
- Year and Date
  2010-03-03
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 低分子シグナル伝達阻害剤の探索と病態解析・医薬開発への応用2010
- Author(s)
  梅澤一夫
- Organizer
  2010年病理学会カンファレンス
- Place of Presentation
  岡山(招待講演)
- Year and Date
  2010-08-06
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Apoptosis and its regulation by chemical ligands. (Invited speaker)2010
- Author(s)
  梅澤一夫
- Organizer
  OOTR the 6^<th> Annual Conference
- Place of Presentation
  Kyoto
- Year and Date
  2010-02-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 阻害剤のケミカルバイオロジーから得られるNF-κBの疾患における役割2010
- Author(s)
  梅澤一夫
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Anti-inflammatory and anticancer activities of novel NF-κB inhibitor DHMEQ and its unique distribution in the body.2010
- Author(s)
  Kazuo Umezawa
- Organizer
  The 15^<th> World Congress on Advances in Oncology, and 13^<th> International Symposium on Molecular Medicine
- Place of Presentation
  Loutraki, Greece(Invited speaker)
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Anticancer activity of novel NF-κB inhibitor DHMEQ and its unique distribution in the body.2010
- Author(s)
  Kazuo Umezawa
- Organizer
  Second World Congress on Cancer 2010(WCC-2010)
- Place of Presentation
  Kottayam, Kerala, India(Invited speaker)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Inhibition of noncanonical NF-kappa B activation by (-)-DHMEQ in vitro and in adult T-cell leukemia cells.2010
- Author(s)
  M.Takeiri, K.Umezawa, et al
- Organizer
  AACR 101th Annual Meeting
- Place of Presentation
  Washington DC.
- Year and Date
  2010-04-17
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Protein chemistry of target molecules for NF-κB inhibitor DHMEQ.2010
- Author(s)
  K.Umezawa
- Organizer
  Keio LCC-Yonsei CBMH Joint Symposium 2010
- Place of Presentation
  日光(Invited speaker)
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 成人T細胞白血病細胞における(-)-DHMEQによるnoncanonical NF-kappa Bの抑制2010
- Author(s)
  竹入雅敏、梅澤一夫, et al
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] エイズリンパ腫の薬物療法の新展開。(招待講演)2009
- Author(s)
  梅澤一夫
- Organizer
  公開シンポジウム「エイズとエイズリンパ腫治療の最前線」
- Place of Presentation
  東京
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Screening and mechanistic study of natural signal transduction inhibitors. (Invited speaker)2009
- Author(s)
  梅澤一夫
- Organizer
  he 12^<th> International Symposium on Traditional Medicine in Toyama 第12回国際伝統医薬シンポジウム-和漢薬の科学基盤形成-
- Place of Presentation
  富山
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 植物由来コノフィリンによるマスト細胞のインテグリン発現と脱顆粒の抑制 Suppression of integrin expression and degranulation by conophylline in mast cells2009
- Author(s)
  岩佐俊, 梅澤一夫
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 抗炎症・抗がん活性のある分子標的医薬の探索と応用。(招待講演)2009
- Author(s)
  梅澤一夫
- Organizer
  第3回ハイテク・リサーチ・センター・シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] (-)-DHMEQによるCXCL12/CXCR4経由の卵巣癌細胞浸潤の抑制。(口演)2009
- Author(s)
  宮西那実, 梅澤一夫
- Organizer
  第13回がん分子標的治療学会学術総会
- Place of Presentation
  徳島
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] (-)-DHMEQによるCXCL12/CXCR4 経由の卵巣癌細胞浸潤の抑制2009
- Author(s)
  宮西那実、梅澤一夫
- Organizer
  (口演)第13回がん分子標的治療学会学術総会
- Place of Presentation
  徳島
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Proteomic analysis of AIDS-related lymphoma expressing proteins that are lowered by NF-κB inhibitor(-)-DHMEQ(エイズ関連リンパ腫細胞におけるNF-κB阻害剤(-)-DHMEQに発現が抑制されるタンパク質のスクリーニング)(口演)2009
- Author(s)
  Y.Kambayashi, K.Umezawa, et al
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Inhibition of CARD11/Bcl-10/Malt1 complex-mediated leukotriene production by a specific NF-kappa B inhibitor, (-)-DHMEQ, in basophils. (oral presentation)2009
- Author(s)
  鈴木絵里子, 梅澤一夫, et al
- Organizer
  2^<nd> European Congress of Immunology
- Place of Presentation
  Berlin, Germany
- Year and Date
  2009-09-13
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 新規AP-1阻害剤の探索、合成と作用機構2009
- Author(s)
  橘みゆき, 石川裕一, 西山繁, 梅澤一夫
- Organizer
  第4回日本ケミカルバイオロジー研究会(口演)
- Place of Presentation
  神戸
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] In vitro and in vivo anti-neoplastic activity of the specific NF-kappa B inhibitor DHMEQ on AIDS-related lymphoma. (Invited speaker)2009
- Author(s)
  K.Umezawa, R.Horie, et al
- Organizer
  The 14^<th> World Congress on Advances in On cology, and 12^<th> International Symposium on Molecular Medicine
- Place of Presentation
  Loutraki, Greece
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] (-)-DHMEQによる noncanonical NF-kappaB 活性化経路の抑制と機構解析 Inhibition of noncanonical NF-kappaB activation by(-)-DHMEQ and the mechanistic study. (口演)2009
- Author(s)
  竹入雅敏, 梅澤一夫
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 新規転写因子AP-1活性阻害剤DTCM-glutarimide の作用機構と生物活性2009
- Author(s)
  兼田亜弓, 橘みゆき, 石川裕一, 西山繁, 梅澤一夫
- Organizer
  第51回天然有機化合物討論会
- Place of Presentation
  名古屋
- Year and Date
  2009-10-07
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Inhibition of CARMAI/Bcl-10/Maltl complex-mediated leukotriene production by a specific NF-kappa B inhibitor, (-)-DHMEQ, in mast cells.2009
- Author(s)
  E. Suzuki, M. Takahata, M. Oya, K. Umezawa
- Organizer
  Keystone Symposia, Allergy and Asthma
- Place of Presentation
  Keystone, CO, USA
- Year and Date
  2009-01-24
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Discovery of a novel AP-1 function inhibitor DTCM-glutarimide derived from an antibiotic 9-methylstreptimidone. (Invited speaker)2009
- Author(s)
  橘みゆき, 梅澤一夫, et al
- Organizer
  The 14^<th> World Congress on Advances in On cology, and 12^<th> International Symposium on Molecular Medicine
- Place of Presentation
  Loutraki, Greece
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Screening of transcription factor inhibitors and application to Yin Yang 1 studies. (Invited speaker)2009
- Author(s)
  梅澤一夫, 鈴木絵里子
- Organizer
  First International Workshop on Prognostic and Therapeutic Roles of Yin Yang 1 in Cancer
- Place of Presentation
  Catania, Italy
- Year and Date
  2009-05-24
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Inhibtion of noncanonical NF-kappaB pathway by(-)-DHMEQ. ((-)-DHMEQによる noncanonical NF-kappa B活性化経路の抑制)2009
- Author(s)
  M.Takeiri, A.Ogasawara, K.Umezawa
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 腎癌細胞表面のSLCトランスポーターOAT1による抗癌剤の取り込みと低酸素の影響。(口演)2009
- Author(s)
  鈴木絵里子, 梅澤一夫, 大家基嗣
- Organizer
  第13回がん分子標的治療学会学術総会
- Place of Presentation
  徳島
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] In vitro and in vivo anti-neoplastic activity of the specific NF-κB inhibitor DHMEQ on human multiple myeloma2009
- Author(s)
  鈴木絵里子, 梅澤一夫, et al
- Organizer
  2^<nd> International Congress on Leukemia Lymphoma Myeloma
- Place of Presentation
  Istanbul, Turkey
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Proteomic analysis of anticancer activity of the specific NF-kappa B inhibitor DHMEQ on AIDS-related lymphoma. (Invited speaker)2009
- Author(s)
  梅澤一夫
- Organizer
  Keio LCC-Yonsei CBMH Joint Symposium 2009
- Place of Presentation
  Gyeongju(慶州)Korea
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 転写因子に対する分子標的医薬の探索と抗癌活性2009
- Author(s)
  梅澤一夫
- Organizer
  バイオEXPO特別講演
- Place of Presentation
  東京
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Screening of anaplastic large cell lymphoma-selective apoptosis inducing agents from natural products. (未分化大細胞リンパ腫選択的アポトーシスを誘導する天然物のスクリーニング)2009
- Author(s)
  T.Toda, R.Horie, K.Umezawa
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 転写因子に対する分子標的医薬の探索と抗癌活性。(特別講演)2009
- Author(s)
  梅澤一夫
- Organizer
  バイオEXPO「癌治療ターゲットとゲノム解析」
- Place of Presentation
  東京台場
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 微生物由来癌細胞遊送阻害物質の探索と paxilline の同定2009
- Author(s)
  松井知野, 大平裕一, 梅澤一夫
- Organizer
  新規素材探索研究会
- Place of Presentation
  新横浜
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 生理活性物質の探索とケミカルバイオロジー2009
- Author(s)
  梅澤一夫
- Organizer
  「生体調節のケミカルバイオロジー」シンポジウム(招待講演)
- Place of Presentation
  前橋
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Inhibition of mast cell functions by conophylline, a plant-derived alkaloid.2009
- Author(s)
  S. Iwasa, K. Umezawa
- Organizer
  Keystone Symposia, Allergy and Asthma
- Place of Presentation
  Keystone, CO, USA
- Year and Date
  2009-01-23
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] (-)-DHMEQによる noncanonical NF-kappa B活性化経路の抑制。(口演)2009
- Author(s)
  竹入雅敏, 梅澤一夫
- Organizer
  第13回がん分子標的治療学会学術総会
- Place of Presentation
  徳島
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 新規AP-1阻害剤の合成と作用機構2009
- Author(s)
  橘みゆき, 石川裕一, 西山繁, 梅澤一夫
- Organizer
  新規素材探索研究会
- Place of Presentation
  新横浜
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] The role of OAT1 on chemosensitivity in renal cell carcinoma cells. (腎癌細胞における有機アニオントランスポーターOAT1の薬剤感受性への寄与)(口演)2009
- Author(s)
  E.Suzuki, K.Umezawa, M.Oya
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Inhibition of CXCL12/CXCL4-mediated cellular invasion by an NF-kappa B inhibitor, (-)-DHMEQ, in ovarian carcinoma cells2009
- Author(s)
  宮西那実, 梅澤一夫
- Organizer
  AACR
- Place of Presentation
  Denver, USA
- Year and Date
  2009-04-18
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 乳癌細胞の浸潤におけるNF-кBとCXCR4の関与。2008
- Author(s)
  鈴木由紀乃, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 肥満細胞からのロイコトリエン産生におけるCBM complexを介したNF-кB活性化の関与。2008
- Author(s)
  鈴木絵里子, 梅澤一夫
- Organizer
  第7回新規素材探索研究会
- Place of Presentation
  横浜
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Covalent biding of(-)-DHMEQ, a potent anticancer agent, to canonical and noncanonical NF-kappa B components.2008
- Author(s)
  M. Takeiri, R. Horie, K. Umezawa
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] (-)-DHMEQの標的分子との結合様式の解明。(口演)2008
- Author(s)
  小澤郁子, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 癌や糖尿病に対する新しい化学療法の開発。2008
- Author(s)
  梅澤一夫
- Organizer
  バイオアカデミックフォーラム(講演)
- Place of Presentation
  東京
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 卵巣癌細胞におけるNF-кBの役割と(-)-DHMEQによる抑制。2008
- Author(s)
  宮西那美, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] non-canonical NF-кB構成因子と(-)-DHMEQの結合解明。2008
- Author(s)
  竹入雅敏, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Management of malignancies by reduction of systemic immune reactions. (Invited speaker)2008
- Author(s)
  E. Suzuki, K. Umezawa
- Organizer
  The Vascular Endothelium, Basic and Clinical Aspects. Seventh International Congress
- Place of Presentation
  Pisa, Italy
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 選択的NFkB阻害剤DHMEQのドナー投与によるマウス膵島肝内移植成績の改善効果2008
- Author(s)
  高橋徹、松本秀一朗、敦賀陽介、葛西弘規、細田充主、渡辺正明、古川博之、松下通明、藤堂省、尾崎倫孝、梅澤一夫
- Organizer
  第20回代用臓器・再生医学研究会
- Place of Presentation
  札幌北海道大学学術交流会館
- Year and Date
  2008-02-02
- Data Source
  KAKENHI-PROJECT-18209041
[Presentation] NF-кB阻害剤のDHMEQのepoxyquinol構造を有するparasitenoneの生物活性。2008
- Author(s)
  高杉亜里紗, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] エイズ関連リンパ腫細胞の表現型解析とNF-кB阻害剤(-)-DHMEQによる抑制。2008
- Author(s)
  神林佑輔, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] "THE IMMUNOMODULATORY EFFECT OF DONOR SPECIFIC TRANSFUSION PLUS NF-kB BLOCKADE BY UTILIZING A NOVEL INHIBITOR, DHMEQ.2008
- Author(s)
  Ryoichi Goto, Kenichiro Yamashita, Takeshi Aoyagi, Shinya Ueki, Rumi Igarashi, Motohiro Uno, Tetsu Oura, Masaaki Watanabe, Tomohiro Shibata, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
- Organizer
  8th international conference
- Place of Presentation
  Berlin, Germany Intercontinental Berlin hotel
- Data Source
  KAKENHI-PROJECT-18209041
[Presentation] Screening of endothelial cell function inhibitors from microorganisms.2008
- Author(s)
  K. Umezawa, O. Ohno
- Organizer
  The 13^<th> World Congress on Advances in Oncology, and 11^<th> International Symposium on Molecular Medicine (Invited speaker)
- Place of Presentation
  Hersonissos, Greece
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Inhibition of cellular invasion by an NF-kappa B inhibitor, (-)-DHMEQ, in ovarian carcinoma cells. (Invited speaker)2008
- Author(s)
  N. Miyanishi, K. Umezawa, et al
- Organizer
  The 13^<th> World Congress on Advances in Oncology, and 11^<th> International Symposium on Molecular Medicine (Invited speaker)
- Place of Presentation
  Hersonissos, Greece
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] NF-кB阻害剤(-)-DHMEQの標的分子の解明。2008
- Author(s)
  山本瑞生, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 生理活性物質の探索とヒト細胞機能の制御。2008
- Author(s)
  梅澤一夫
- Organizer
  第26回日本ヒト細胞学会学術集会(特別講演)
- Place of Presentation
  東京
- Year and Date
  2008-08-31
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] NF-kappa B阻害剤(-)-DHMEQによる癌・骨破壊の抑制。2008
- Author(s)
  梅澤一夫
- Organizer
  第11回癌と骨病変研究会(招待講演)
- Place of Presentation
  東京
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] (-)-DHMEQによるhistamine産生とC/EBPβ阻害の機構。2008
- Author(s)
  二宮陽子, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Screening of microbial secondary metabolites that inhibit endothelial cell growth. (Invited speaker)2008
- Author(s)
  K. Umezawa, O. Ohno
- Organizer
  The Vascular Endothelium, Basic and Clinical Aspects. Seventh International Congress
- Place of Presentation
  Pisa, Italy
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Screening of bioactive metabolites that inhibit cancer growth and natural immune reactions.2008
- Author(s)
  K. Umezawa
- Organizer
  The First International Symposium of Nanjing "Basic and Clinical Interface in Targeted Cancer Therapy", (Invited speaker)
- Place of Presentation
  Nanjing, China
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] Activation of macrophages by cytokines secreted from cancer cells.2008
- Author(s)
  A. Takasugi, E. Suzuki, K. Umezawa
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] NF-кB阻害剤(-)-DHMEQによるマスト細胞の活性化抑制。2008
- Author(s)
  鈴木絵里子, 梅澤一夫
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 抗炎症物質の探索と新しい医療への応用(Screening of anti-inflammatory agents and application to new therapy)。2008
- Author(s)
  梅澤一夫
- Organizer
  理研セミナー(招待講演)
- Place of Presentation
  埼玉県和光市
- Year and Date
  2008-05-28
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 生理活性物質の探索とヒト細胞機能の制御2008
- Author(s)
  梅澤一夫
- Organizer
  第26回日本ヒト細胞学会学術集会
- Place of Presentation
  東京(特別講演)
- Year and Date
  2008-08-30
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] NF-кB阻害剤(-)-DHMEQの標的分子の解明と結合体モデルの合成。2008
- Author(s)
  小澤郁子, 梅澤一夫
- Organizer
  第3回日本ケミカルバイオロジー研究会(口演)
- Place of Presentation
  東京
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-20611015
[Presentation] 新規NF-kB阻害剤"DHMEQ"の漫性拒絶反応抑制効果2007
- Author(s)
  植木伸也、山下健一郎、青柳武史、鈴木友己、谷口雅彦、嶋村剛、梅澤一夫、古川博之、尾崎倫孝、藤堂省
- Organizer
  第107回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-18209041
[Presentation] "EFFECT OF A NOVEL NF-kB INHIBITOR, DEHYDROXYMETHYLEPOXYQUINOMICIN IN COMBINATION WITH DONOR SPECIFIC TRANSFUSION IN MOUSE HEART TRANSPLANTATION.2007
- Author(s)
  Ryoichi Goto, Kenichiro Yamashita, Takeshi Aoyagi, Motohiro Uno, Shinya Ueki, Tomoo Itoh, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
- Organizer
  American Transplant Congress
- Place of Presentation
  San Francisco, CA Moscone West Convention Cneter
- Data Source
  KAKENHI-PROJECT-18209041
[Presentation] NF-κB as a target of anticancer agents : Anticancer activity and molecular target of an NF-κB inhibitor, DHMEQ.(シンポジウム講演)2007
- Author(s)
  K. Umezawa
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16073217
[Presentation] Donor pretreatment with a novel NF-kB inhibitor, DHMEQ can a lleviate the graft damage in syngenic marginal islet transplantation.2007
- Author(s)
  Tohru Takahashi, Suichiro Matsumoto, Yosuke Tsuruga, Hironori Kasai, Masaaki Watanabe, Michitaka Ozaki, Hiroyuki Furukawa, Michiaki Matsushita, Kazuo Umezawa and Satoru Todo
- Organizer
  Cell Transplantation society 2007 Joint Conference
- Place of Presentation
  Minneapolisハイアットリージェンシー
- Data Source
  KAKENHI-PROJECT-18209041
[Presentation] Isolation of novel metabolite migracin from Streptomyces that inhibits migration and invasion of ovarian carcinoma cells
- Author(s)
  Tamami Ukaji, Kazuo Umezawa
- Organizer
  Regional International Gynecologic Cancer Society (IGCS) Meeting
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2014-05-16 – 2014-05-18
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Conophyllineの抗ハンチントン病作用
- Author(s)
  佐藤夏実、笹澤有紀子、梅澤一夫、清水史郎
- Organizer
  日本ケミカルバイオロジー学会　第9回年会
- Place of Presentation
  大阪大学（大阪府・豊中市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24310167
[Presentation] 新規NF-κB阻害剤Exo-ene EQによる卵巣がん細胞の浸潤抑制
- Author(s)
  Kulrawee Sidthipong、梅澤一夫
- Organizer
  第18回日本がん分子標的治療学会2014.6.25-27
- Place of Presentation
  仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 放線菌由来新規がん細胞遊走阻害物質migracinの単離と卵巣がん細胞浸潤の抑制
- Author(s)
  宇梶珠未、梅澤一夫
- Organizer
  第18回日本がん分子標的治療学会2014.6.25-27
- Place of Presentation
  仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 新規epoxide-free (-)-DHMEQ誘導体の分子デザイン・合成と抗炎症活性
- Author(s)
  Kulrawee Sidthipong、小林進、梅澤一夫
- Organizer
  第56回天然有機化合物討論会
- Place of Presentation
  高知
- Year and Date
  2014-10-15 – 2014-10-17
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 放線菌由来新規細胞遊走阻害物質migracinの単離と管腔形成およびがん細胞浸潤の抑制
- Author(s)
  宇梶　珠未、梅澤一夫
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 低分子シグナル伝達阻害剤の探索とマトリクス修飾への応用
- Author(s)
  梅澤一夫
- Organizer
  第46回日本結合組織学会学術大会　第61回日本マトリクス研究会大会　合同集会
- Place of Presentation
  名古屋
- Year and Date
  2014-06-05 – 2014-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Inhibition of cancer cell invasion by bioactive metabolites
- Author(s)
  Kazuo Umezawa
- Organizer
  The 19th World Congress on Advances in Oncology, and 17th International Symposium on Molecular Medicine
- Place of Presentation
  Athens, Greece
- Year and Date
  2014-10-09 – 2014-10-11
- Invited
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Isolation of novel cell migration inhibitor migracins from Streptomyces and inhibition of cellular invasion in ovarian carcinoma cells
- Author(s)
  Tamami Ukaji, Kazuo Umezawa
- Organizer
  13th International Congress on Targeted Anticancer Therapies
- Place of Presentation
  Paris
- Year and Date
  2015-03-02 – 2015-03-04
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] 微生物由来新規細胞遊走阻害物質migracinの単離と卵巣がん細胞浸潤の抑制
- Author(s)
  宇梶珠未、梅澤一夫
- Organizer
  日本ケミカルバイオロジー学会
- Place of Presentation
  大阪
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26350975
[Presentation] Suppression of cellular invasion by novel NF-kappa B inhibitor Exo-ene EQ in ovarian carcinoma cells.
- Author(s)
  Kulrawee Sidthipong, Kazuo Umezawa
- Organizer
  The 19th World Congress on Advances in Oncology, and 17th International Symposium on Molecular Medicine
- Place of Presentation
  Athens, Greece
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-26350975

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UMEZAWA Umezawa 梅澤 一夫

梅沢 一夫 ウメザワ カズオ

UMEZAWA Kazuo 梅澤 一夫

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Screening of cancer cell 3D invasion inhibitors from microbial metabolitesPrincipal Investigator

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Screening of NF-kappa B inhibitors having new core structure and application to aggressive cancer treatmentPrincipal Investigator

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Bio-imaging of peritoneal metastasis and molecular design of inhibitorsPrincipal Investigator

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Molecular design and synthesis of soluble NF-κB inhibitor and suppression of ovarian carcinomaPrincipal Investigator

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天然由来シグナル伝達阻害物質の探索と医薬への応用Principal Investigator

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癌細胞のアポトーシス耐性および分化誘導耐性克服物質の探索Principal Investigator

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UMEZAWA Umezawa 梅澤一夫

梅沢一夫ウメザワカズオ

UMEZAWA Kazuo 梅澤一夫