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umezawa kazuo  梅澤 一夫

ORCIDConnect your ORCID iD *help
… Alternative Names

梅澤 一夫  ウメザワ カズオ

UMEZAWA Umezawa  梅澤 一夫

梅沢 一夫  ウメザワ カズオ

UMEZAWA Kazuo  梅澤 一夫

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Researcher Number 70114402
External Links
Affiliation (Current) 2022: 愛知医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2022: 愛知医科大学, 医学部, 教授
2012 – 2019: 愛知医科大学, 医学部, 教授
2004 – 2011: 慶應義塾大学, 理工学部, 教授
2010: 慶応義塾大学, 理工学部, 教授
2008: 慶応義塾大学, 理工学部, 教授 … More
2004: 慶応義塾大学, 理工学部, 教授
2003: 慶応大学, 理工学部, 教授
2000 – 2002: 慶應義塾大学, 理工学部, 教授
1999 – 2000: 慶応義塾大学, 理工学部, 教授
1995 – 1996: 慶応義塾大学, 理工学部, 教授
1994: 慶應義塾大学, 理工学部, 教授
1991 – 1992: 慶応義塾大学, 理工学部, 教授
1990 – 1992: 慶応大学, 理工学部, 教授
1987: Institute for Microbial Chemistry, 副所長
1986: 東京大学, 医科学研究所, 助教授 Less
Review Section/Research Field
Principal Investigator
Science and Engineering / Chemical biology / Chemical biology / Chemical biology
Except Principal Investigator
医学一般 / 医薬分子機能学 / General surgery / Biomedical engineering/Biological material science / 膠原病・アレルギー・感染症内科学 / Chemical biology … More / Living organism molecular science / Urology / 広領域 / Basic Section 53010:Gastroenterology-related Less
Keywords
Principal Investigator
浸潤 / 転移 / DHMEQ / 放線菌 / スクリーニング / NF-κB / 分子デザイン / NF-kappa B / コノフィリン / メラノーマ … More / 抗癌剤 / 癌 / 有機化学 / 生理活性物質 / 微生物 / 卵巣癌 / 遊走 / Exo-ene EQ / 阻害剤 / エピサイクロフェリトール / α-グルコシダーゼ / マウスメラノーマ / ルイス肺がん / Con A結合蛋白 / がん遺伝子 / レクチン / 子宮体がん / H抗原 / アポトーシス / 植物 / 生合成 / 膵腺癌細胞 / 応用微生物 / 細胞・組織 / 糖尿病 / シグナル伝達 / 生理活性 / エポキシキノマイシン / インスリン / ヘプタデプシン / リポ多糖 / 腹腔内播種 / バイオイメージング / 腹腔内転移 / DTCM-glutarimide / migracin / pyrapaxilline / 卵巣がん / アノイキス / 探索プローブ / 標的タンパク質 / 光プローブ / 天然物 / がん / 炎症 / desmal / 分子標的 / SEMBL / (-)-DHMEQ / がん細胞 / 三次元培養 / I-kappa B kinase / ketomycin / IKK-beta … More
Except Principal Investigator
NF-κB / PI代謝回転阻害剤 / 単球 / 貧食能 / 活性酸素 / 磁気泳動細胞分離 / ピリミジンヌクレオシド化合物 / 蛋白リン酸化酵素阻害剤 / ミオシンL鎖キナ-ゼ阻害剤 / MDS由来細胞株 / AraC感受性 / アポプト-シス / ラット骨髄前脂肪細胞株RECAー16 / 分化誘導剤 / 脂質性合成シアロ糖化合物 / 特異的チロシンキナ-ゼ阻害物質 / 抗癌剤排出性P糖蛋白 / 活性型ビタミンD3 / トランスフォ-ミング増殖因子(TGF)β / 造血因子MーCSF / インスリン受容体βサブユニット自己リン酸化反応 / 免疫機能 / Fcレセプタ- / モノクロ-ナル抗体 / フロ-サイトメ-タ / 糖鎖含有リコンビナントD因子 / チロシンキナーゼ阻害剤 / 非リン酸化RB遺伝子産物 / 糖転移酵素系 / エンドヌクレアーゼ / アポプトーシス / フラバノン化合物デスマール / 免疫 / Fcレセプター / モノクローナル抗体 / フローサイトメータ / レチノイン酸 / 分化誘導療法 / 急性前骨髄球性白血病 / Am-80 / 細胞内レチノイン酸結合蛋白 / PML / RARA / 亜砒酸 / レチノイドアンタゴニスト / 生体機能 / 機能性分子 / 螢光 / シグナル伝達 / 画像 / 合成化学 / 内皮細胞 / 毛細血管 / 再生医療 / 血管新生 / 内皮前駆細胞 / 低酸素 / コラーゲンゲル / バイオメカニクス / 基質 / コラーゲン / 足場構造 / NF-kB / 免疫抑制 / 臓器保存 / 虚血再灌流障害 / 臓器移植 / 肝移植 / 拒絶反応 / NF kappa B / 虚血再灌流 / NF-KB / DHMEQ / 虚血・再かん流障害 / 抗リン脂質抗体症候群 / 抗β2-グリコプロテインI抗体 / 動物モデル / NF-kappaB / 抗β2グリコプロテインI抗体 / シグナル伝達阻害薬 / 血小板機能 / ケモカイン / 膵ラ氏島移植 / 分子標的治療 / CD40 / 骨関連疾患 / Pirin / 破骨細胞 / 破骨細胞分化 / ケミカルバイオロジー / RANKL / 骨疾患 / 低分子化合物 / 骨粗鬆症 / 骨転移 / 構造活性相関 / 人工配位子 / ファルネシルトランスフェラーゼ / 癌遺伝子 / Ras蛋白質 / man-made chelator / farnesyltransferase / oncogene / Ras protein / 微生物代謝産物 / 阻害剤 / スフィンゴミエリナーゼ / 酸性スフィンゴミエリナーゼ / microbial product / acidic sphyngomyelinase / inhibitor / 泌尿器系癌 / アポトーシス / 転移 / 悪液質 / 前立腺癌 / 放射線治療 / 細胞周期 / IL-6 / STAT3 / 膀胱癌 / 殺細胞効果 / urological malignancy / apoptosis / metastasis / cytokine / フィブロネクチン / 細胞接着 / 細胞伸展 / 糖タンパク質 / 血漿タンパク質 / 接着性糖タンパク質 / タンパク質 / 細胞表面 / 細胞間マトリックス / 血液 / Fibronectin / Cell attachment / Cell spreading / Glycoprotein / B型肝炎ウイルス / 侵入機構 / 侵入阻害 / 感染制御 Less
  • Research Projects

    (25 results)
  • Research Products

    (435 results)
  • Co-Researchers

    (97 People)
  •  Elucidation of the mechanism of hepatitis B virus entry and control of infection by entry inhibitors

    • Principal Investigator
      伊藤 清顕
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Aichi Medical University
  •  Screening of cancer cell 3D invasion inhibitors from microbial metabolitesPrincipal Investigator

    • Principal Investigator
      Umezawa Kazuo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical biology
    • Research Institution
      Aichi Medical University
  •  Screening of NF-kappa B inhibitors having new core structure and application to aggressive cancer treatmentPrincipal Investigator

    • Principal Investigator
      Umezawa Kazuo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical biology
    • Research Institution
      Aichi Medical University
  •  Development of novel drug for bone-related diseases using Pirin inhibitors

    • Principal Investigator
      SIMIZU Siro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical biology
    • Research Institution
      Keio University
  •  Bio-imaging of peritoneal metastasis and molecular design of inhibitorsPrincipal Investigator

    • Principal Investigator
      UMEZAWA Kazuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical biology
    • Research Institution
      Aichi Medical University
      Keio University
  •  Development of a new strategy for pancreatic islet transplantation by molecular targeting agents

    • Principal Investigator
      YAMASHITA Kenichiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Hokkaido University
  •  Studies on thrombophilic diathesis and development of a novel molecular-targeting therapy in antiphospholipid syndrome

    • Principal Investigator
      KUBOTA Tetsuo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical and Dental University
  •  Molecular design and synthesis of soluble NF-κB inhibitor and suppression of ovarian carcinomaPrincipal Investigator

    • Principal Investigator
      UMEZAWA Kazuo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical biology
    • Research Institution
      Keio University
  •  Development of safe liver transplantation by modulation of transcription factor, nuclear factor kappa B (NF-kB)

    • Principal Investigator
      TODO Satoru
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General surgery
    • Research Institution
      Hokkaido University
  •  力学的刺激による毛細血管3次元ネットワーク形成の促進と再生医療への応用

    • Principal Investigator
      谷下 一夫
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Keio University
  •  天然由来シグナル伝達阻害物質の探索と医薬への応用Principal Investigator

    • Principal Investigator
      梅澤 一夫 (梅沢 一夫)
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Keio University
  •  Pathophysiological role of NF k B and the efficacy of a novel NF K B inhibitor in urological cancers

    • Principal Investigator
      MURAI Masaru
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      Keio University
  •  Screening for selective acidic sphyngomyelinase inhibitor using microbial product

    • Principal Investigator
      IKEDA Yoko
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      Microbial Chemistry Research Foundation
  •  癌細胞のアポトーシス耐性および分化誘導耐性克服物質の探索Principal Investigator

    • Principal Investigator
      梅澤 一夫 (梅沢 一夫)
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Keio University
  •  微生物、植物由来アポトーシス耐性克服物質の探索Principal Investigator

    • Principal Investigator
      梅沢 一夫
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Science and Engineering
    • Research Institution
      Keio University
  •  画像化能を有する生体機能探査分子の設計原理の開発

    • Principal Investigator
      樋口 恒彦
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      The University of Tokyo
  •  Molecular Design of Ras Farnesyltransferase Inhibitors

    • Principal Investigator
      OTSUKA Masami
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kumamoto University
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  糖鎖生合成修飾による転移の抑制Principal Investigator

    • Principal Investigator
      梅沢 一夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  糖鎖生合成修飾による転移の抑制Principal Investigator

    • Principal Investigator
      梅沢 一夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Keio University
  •  細胞分化誘導剤の臨床応用に関する基礎的研究

    • Principal Investigator
      斉藤 政樹
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  磁気および発光プローブを用いた担癌生体免疫能分析システムの研究

    • Principal Investigator
      南谷 晴之
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医学一般
    • Research Institution
      Keio University
  •  細胞分化誘導剤の臨床応用に関する基礎的研究

    • Principal Investigator
      斎藤 政樹
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  磁気効果と発光現象を利用した担癌生体免疫測定システムの開発と総合的な分析

    • Principal Investigator
      南谷 晴之
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医学一般
    • Research Institution
      Keio University
  •  Physiology and Biochemistry of Fibronectin; Comprehensive Approaches from Basic to Clinical Studies.

    • Principal Investigator
      MASAO Hayashi
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      広領域
    • Research Institution
      Ochanomizu University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] 抗悪性腫瘍薬の作用機構解析法。曽根三郎、鶴尾隆編:がん分子標的治療研究実践マニュアル2009

    • Author(s)
      梅澤一夫
    • Total Pages
      4
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] 新しい抗癌剤の分子標的NF-κB。菅野純夫編:臨床遺伝子学'09-がんの遺伝子学-最新医学9月増刊号2009

    • Author(s)
      鈴木絵里子, 梅澤一夫
    • Total Pages
      9
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] 位置・立体選択的反応を鍵段階とする酵素-化学複合合成法の開発、「複合糖質の化学と最新応用技術」(正田晋一郎、稲津敏行編)2009

    • Author(s)
      橘田和憲, 濱田学, 梅澤一夫, 東利則, 須貝威
    • Total Pages
      9
    • Publisher
      シーエムシー
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] NF-кBの役割と阻害剤の抗癌活性。鶴尾隆編「癌の分子標的」2008

    • Author(s)
      鈴木絵里子, 梅澤一夫
    • Total Pages
      6
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] Chemo-immunosensitization of resistant B-NHL as a result of rituximab (anti-CD20 mAb)-mediated inhibition of cell survival signaling pathways. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy2008

    • Author(s)
      K. Umezawa, E. Suzuki
    • Total Pages
      12
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] NF-кBを標的とする抗癌剤。医学のあゆみ別冊2008

    • Author(s)
      鈴木絵里子, 梅澤一夫
    • Total Pages
      5
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] 生化学の基礎知識とケミカルバイオロジー。長田裕之編「入門ケミカルバイオロジー」2008

    • Author(s)
      梅澤一夫
    • Total Pages
      18
    • Publisher
      オーム社
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] シグナル伝達阻害剤の単離、分子デザインと生物活性。上村大輔監修 : 新規素材探索-医薬品リード化合物・食品素材を求めて2008

    • Author(s)
      梅澤一夫
    • Total Pages
      11
    • Publisher
      CMC出版
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Book] 腐敗と再生2004

    • Author(s)
      梅澤一夫
    • Total Pages
      15
    • Publisher
      慶應義塾大学出版会
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Book] シグナル伝達因子とがん治療薬開発-NF-kappa B阻害剤(-)-DHMEQバイオ医薬開発技術とシーズ

    • Author(s)
      鈴木絵里子, 梅澤一夫
    • Publisher
      CMC出版(印刷中)
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model2020

    • Author(s)
      S. Morita, K. Shinoda, T. Yoshida, M. Shimoda, Y. Kanno, R. Mizuno, H. Kono, H. Asanuma, K. Nakagawa, K. Umezawa, M. Oya
    • Journal Title

      BMC Pharmacology and Toxicology

      Volume: in press

    • DOI

      10.21203/rs.2.21990/v2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Anti-inflammatory effect of dehydroxymethylepoxyquinomicin, a nuclear factor-κB inhibitor, on endotoxin-induced uveitis in rats in vivo and in vitro2020

    • Author(s)
      Y. Ando, H. Keino, A. Kudo, A. Hitrakata, A. A. Okada, K. Umezawa
    • Journal Title

      Ocul Immunol Inflamm

      Volume: in press Pages: 240-248

    • DOI

      10.1080/09273948.2019.1568502

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K11490
  • [Journal Article] Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin2020

    • Author(s)
      L. Wang, M. Li, Y. Lin, S. Du, Z. Liu, J. Ju, H. Suzuki, M. Sawada, K. Umezawa
    • Journal Title

      The Journal of Antibiotics

      Volume: in press Pages: 622-629

    • DOI

      10.1038/s41429-020-0302-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967, KAKENHI-PLANNED-18H05429
  • [Journal Article] Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin2020

    • Author(s)
      K. Umezawa, Y. Lin
    • Journal Title

      BBA-Proteins and Proteomics 1868 (2020) 140412

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Direct and indirect anticancer activity of plant-derived alkaloid conophylline2020

    • Author(s)
      K. Umezawa, K. Shirabe
    • Journal Title

      Critical Reviews in Oncogenesis

      Volume: in press

    • DOI

      10.1615/critrevoncog.2020034129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] PD-L1 expression enhancement by infiltrating macrophage-derived tumor necrosis factor-alpha leads to poor pancreatic cancer prognosis.2019

    • Author(s)
      N. Ishii, K. Araki, T. Yokobori, K. Hagiwara, G. Dolgormaa, T. Yamanaka, T. Handa, M. Tsukagoshi, T. Igarashi, A. Watanabe, N. Kubo, N. Harimoto, A. Masamune, K. Umezawa, H. Kuwano, K. Shirabe
    • Journal Title

      Cancer Sci

      Volume: 10 Pages: 310-310

    • DOI

      10.1111/cas.13874

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-18K16370, KAKENHI-PROJECT-16H06257, KAKENHI-PROJECT-17K10704
  • [Journal Article] The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation2019

    • Author(s)
      H. Fu, M. Alabdullah, J. Grosmann, F. Spieler, R. Abdosh, V. Lutz, K. Kalies, K. Knopp, K. Rieckmann, S. Koch, M. Nutsias, C. Pilowski, J. Dutzmann D. Sedding, S. Huttelmaier, K. Umezawa, K. Werdan, H. Loppnow
    • Journal Title

      Cell Death and Disease

      Volume: 10 Pages: 880-880

    • DOI

      10.1038/s41419-019-2109-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum2019

    • Author(s)
      H. He, X. Gao, X. Wang, X. Li, X. Jiang, Z. Xie, K. Ma, J. Ma, K. Umezawa, Y. Zhang
    • Journal Title

      International Immunopharmacology

      Volume: 71 Pages: 43-51

    • DOI

      10.1016/j.intimp.2019.03.015

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition2019

    • Author(s)
      X. Jiang, H. He, Z. Xie, H. Wen, X. Li, Xin Li, J. Ma, K. Umezawa, Y. Zhang
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: in press Pages: 32-39

    • DOI

      10.1080/08923973.2018.1510962

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Growth inhibitory effects of dipotassium glycyrrhizinate in glioblastoma cell lines by targeting microRNAs through the NF-κB signaling pathway2019

    • Author(s)
      G. A. Bonafe, J. S. dos Santos, J. V. Ziegler, K. Umezawa, M. L. Ribeiro, T. Rocha, M. M. Ortega
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 13

    • DOI

      10.3389/fncel.2019.00216

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Causes and mechanisms of peritoneal fibrosis and possible application of NF-κB inhibitor for prevention and treatment2019

    • Author(s)
      A. Breborowicz, K. Umezawa
    • Journal Title

      Journal of Medical Science

      Volume: 88 Pages: 102-108

    • DOI

      10.20883/jms.352

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion2019

    • Author(s)
      Y. Lin, Y. Chen, T. Ukaji, S. Okada, K. Umezawa
    • Journal Title

      J. Antibiot.

      Volume: 72 Pages: 148-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Conophylline Inhibits High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice2019

    • Author(s)
      T. Ohashi, Y. Nakade, M. Ibusuki, R Kitano, T. Yamauchi, S. Kimoto, T. Inoue, Y. Kobayashi, N. Ishii, Y. Sumida, K. Ito, H. Nakao, K. Umezawa, M. Yoneda
    • Journal Title

      Plos one

      Volume: electronic

    • DOI

      10.1371/journal.pone.0210068

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K09442
  • [Journal Article] Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC2019

    • Author(s)
      S.-L. Ryan, S. Beard, M. P. Barr, K. Umezawa, S. Heavey, P. Godwin, S. G. Gray, D. Cormican, S. P. Finn, K. A. Gately, A. M. Davies, E. W. Thompson, D. J. Richard, K. J. O’Byrne, M. N. Adams, A.-M. Baird
    • Journal Title

      Lung Cancer

      Volume: 135 Pages: 217-227

    • DOI

      10.1016/j.lungcan.2019.07.006

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] JAK/STAT3 and NF-κB Signaling Pathways Regulate Cancer Stem-Cell Properties in Anaplastic Thyroid Cancer Cells2019

    • Author(s)
      K. Shiraiwa, M. Mitsutake, Y. Nakazawa, T. Ogi, K. Suzuki, V. Saenko, K. Umezawa, S. Yamashita, K. Tsukamoto
    • Journal Title

      Thyroid

      Volume: in press Pages: 674682-674682

    • DOI

      10.1089/thy.2018.0212

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-17H01877, KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-19K07471, KAKENHI-PROJECT-19K09913, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-19KK0267, KAKENHI-PROJECT-16H05832, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-16K08912, KAKENHI-PROJECT-16K09804
  • [Journal Article] Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models2018

    • Author(s)
      K. Umezawa, I. Kojima, S. Simizu, Y. Lin, H. Fukatsu, N. Koide, Y. Nakade and M. Yoneda
    • Journal Title

      Human Cell

      Volume: 31 Pages: 95-101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] DTCM-glutarimide delays growth and radiosensitizes glioblastoma.2018

    • Author(s)
      G. BM. Roberto, H. H. Paiva, L. E. B. deSouza, J. A. Pezuk, G. M. Vieira, H. F. deOliveira, K. Umezawa, L. G. Tone and M. S. Brassesco
    • Journal Title

      Anti-cancer Agents in Medicinal Chemistry

      Volume: -

    • DOI

      10.2174/1871520618666180423105740

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] The plant alkaloid conophylline inhibits matrix formation of fibroblasts2018

    • Author(s)
      T. Tezuka, A. Ota, S. Karnan, K. Matsuura, K. Yokoo, Y. Hosokawa, D. Vigetti, A. Passi, S. Hatano, K. Umezawa, H. Watanabe
    • Journal Title

      J. Biol. Chem.

      Volume: 293 Pages: 20214-20226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Inhibition of late and early phases of cancer metastasis by NF-κB inhibitor DHMEQ derived from microbial bioactive metabolite epoxyquinomicin: A review.2018

    • Author(s)
      Y. Lin, T. Ukaji, N. Koide and K. Umezawa
    • Journal Title

      Int. J. Mol. Sci.

      Volume: -

    • DOI

      10.3390/ijms19030729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration.2018

    • Author(s)
      T. Fujii, N. Fujita, S. Suzuki, K. Watanabe, T. Tsuji, K. Ishii, T. Takaki, K. Umezawa, T. Miyamoto, K. Horiuchi, M. Matsumoto, M. Nakamura
    • Journal Title

      J Orthop Res

      Volume: -

    • DOI

      10.1002/jor.23787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-15K10420
  • [Journal Article] NF-kappa B inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1 beta production: Inhibition of PM2.5-induced inflammation model.2018

    • Author(s)
      Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
    • Journal Title

      Molecular Medicine Report

      Volume: 18 Pages: 5279-5285

    • DOI

      10.3892/mmr.2018.9533

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K00937, KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K08866, KAKENHI-PROJECT-26305023
  • [Journal Article] Conophylline inhibits non-alcoholic steatohepatitis in mice.2017

    • Author(s)
      Y. Nakade, K. Sakamoto, T. Yamauchi, Tadahisa Inoue, Y. Kobayashi, T. Yamamoto, N. Ishii, T. Ohashi; Y. Sumida; K. Ito, H. Nakao, Y. Fukuzawa, K. Umezawa and M. Yoneda
    • Journal Title

      PLOS One

      Volume: 12(6)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Inhibition of MMP-2-mediated cellular invasion by NF-kappa B inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis2017

    • Author(s)
      T. Ukaji, Y. Lin, S. Okada and K. Umezawa
    • Journal Title

      Biochem. Biophys. Res. Commun. 485: 76-81, 2017

      Volume: 485 Pages: 76-81

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis.2017

    • Author(s)
      T. Ikezoe, J. Yang, C. Nishioka, K. Umezawa and A. Yokoyama
    • Journal Title

      Bone Marrow Transplantation

      Volume: 52 Pages: 245-251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Novel p-terphenyl glycoside with a rare 2,6-dideoxy- hexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration.2017

    • Author(s)
      L. Wang, M. Li, J. Tang, Y. Y. Lin, K. Sidthipong, N. Sumida, N. Kushida and K. Umezawa
    • Journal Title

      J. Antibiot.

      Volume: 70 Pages: 987-990

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] The microenvironmental stromal cells abrogate NF-κB inhibitor induced apoptosis in chronic lymphocytic leukemia2017

    • Author(s)
      C-P. Simon-Gabriel, K. Foerster, M. Benkisser-Petersen, D. Bleckmann, N. Thornton, K. Umezawa, S. Decker, C. Dierks, M. Burger, H. Veelken, R. Claus, J. Duyster, K. Zirlik
    • Journal Title

      Hematologica

      Volume: -

    • DOI

      10.3324/haematol.2017.165381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor.2017

    • Author(s)
      K. Sidthipong, J. Ma, W. L. Yu, Y. F. Wang, S. Kobayashi, S. Kishino , N. Koide, T. Yokochi, K. Kato, S. Okada and K. Umezawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Pages: 562-567

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.2017

    • Author(s)
      M. El-Salhy, K. Umezawa, J. G. Hatlebakk and O. H. Gilja
    • Journal Title

      Mol. Med. Reports

      Volume: 15 Pages: 2106-2112

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis2017

    • Author(s)
      M. El-Salhy, K. Umezawa, J. G. Hatlebakk and O. H. Gilja
    • Journal Title

      Mol. Med. Reports

      Volume: 15 Pages: 2106-2112

    • DOI

      10.3892/mmr.2017.6266

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Rational design, synthesis and in vitro evaluation of novelexo-methylene butyrolactone salicyloylamide as NF-κB inhibitor2017

    • Author(s)
      K. Sidthipong, J. Ma, W. L. Yu, Y. F. Wang, S. Kobayashi, S. Kishino , N. Koide, T. Yokochi, K. Kato, S. Okada and K. Umezawa
    • Journal Title

      Bioorg. Med. Chem. Lett. 27: 562-566, 2017.

      Volume: 27 Pages: 562-566

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of MMP-2-mediated cellular invasion by NF-kappa B inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis.2017

    • Author(s)
      T. Ukaji, Y. Lin, S. Okada and K. Umezawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 485 Pages: 76-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice.2017

    • Author(s)
      X. Jiang, B. Wei, Y. Lan, C. Dai, Y. Gu, J. Ma, X. Liu, K. Umezawa and Y. Zhang
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: 39:3 Pages: 157-164

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice2017

    • Author(s)
      X. Jiang, B. Wei, Y. Lan, C. Dai, Y. Gu, J. Ma, X. Liu, K. Umezawa and Y. Zhang
    • Journal Title

      Immunopharmacology and Immunotoxicology 39: 157-164, 2017

      Volume: 39 Pages: 157-164

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Molecular design of sugar-free migracin analog migracinal that inhibits ovarian cancer cell migration and invasion.2017

    • Author(s)
      T. Ukaji, N. Koide, Y. Lin, K. Banno, S. Gantsev and K. Umezawa
    • Journal Title

      Creative Surgery and Oncology

      Volume: 7 (4) Pages: 16-20

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Journal Article] The neuroprotective effect of rapamycin as a modulator of the mTOR-NF-κB axis during retinal Inflammation.2016

    • Author(s)
      Okamoto T, Ozawa Y, Kamoshita M, Osada H, Toda E, Kurihara T, Nagai N, Umezawa K, Tsubota K
    • Journal Title

      PLOS ONE

      Volume: 11(1) Pages: 1-14

    • DOI

      10.1371/journal.pone.0146517

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10881, KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-15K10903, KAKENHI-PROJECT-16K20329
  • [Journal Article] Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.2016

    • Author(s)
      M. El-Salhy and K. Umezawa
    • Journal Title

      International J. Molecular Medicine

      Volume: 37 Pages: 556-564

    • DOI

      10.3892/ijmm.2016.2481

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Angiopoietin-like protein 2 is a multistep regulator of inflammatory neovascularization in a murine model of age-related macular degeneration2016

    • Author(s)
      M. Hirasawa, K. Takubo, H. Osada, S. Miyake, E. Toda, M. Endo, K. Umezawa, K. Tsubota, Y. Oike and Y. Ozawa
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Pages: 7373-7385

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Effects of AP-1 and NF-kappa B inhibitors on colonic endocrine cells in rats with TNBS-induced colitis2016

    • Author(s)
      M. El-Salhy and K. Umezawa
    • Journal Title

      Molecular Medicine Reports 14: 1515-1522, 2016

      Volume: 14 Pages: 1515-1522

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Design and synthesis of 15-deoxyspergualin-biotin conjugates as novel binding probes for target protein screening.2016

    • Author(s)
      M. Morioka, K. Kato, and K. Umezawa
    • Journal Title

      J. Antibiotics

      Volume: in press

    • DOI

      10.1038/ja.2016.32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Angiopoietin-like protein 2 is a multiple regulator of inflammatory neovascularization in a murine model of age-related macular degeneration.2016

    • Author(s)
      M. Hirasawa, K. Takubo, H. Osada, S. Miyake, E. Toda, M. Endo, K. Umezawa, K. Tsubota, Y. Oike and Y. Ozawa
    • Journal Title

      J Biol Chem.

      Volume: 291 Pages: 7373-7385

    • DOI

      10.1074/jbc.m115.710186

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-25461192, KAKENHI-PROJECT-25462734, KAKENHI-PUBLICLY-15H01520, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-15K10903, KAKENHI-PROJECT-26670405
  • [Journal Article] Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis2016

    • Author(s)
      M. El-Salhy, T. Mazzawi, K. Umezawa and O. H. Jilja
    • Journal Title

      International J. Mol. Med.

      Volume: -

    • DOI

      10.3892/ijmm.2016.2787

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] A novel anti-inflammatory agent, DTCM-glutarimide, ameliorates murine models of inflammatory bowel disease.2016

    • Author(s)
      N. Ichikawa, K. Yamashita, T. Funakoshi, S. Ichihara, M. Fukai, M. Ogura, N. Kobayashi, M. Zaitsu, T. Yoshida, S. Shibasaki, Y. Koshizuka, Y. Tsunetoshi, M. Sato, T. Einama, M. Ozaki, K. Umezawa, T. Suzuki and S. Todo
    • Journal Title

      Inflammation Research

      Volume: 65 Pages: 245-260

    • DOI

      10.1007/s00011-015-0911-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of NF-κB activity enhances sensitivity to anticancer drugs in cholangiocarcinoma cells.2016

    • Author(s)
      W. Seubwai, K. Vaeteewoottacharn, R. Kraiklang, K. Umezawa, S. Okada and S. Wongkham
    • Journal Title

      Oncology Research

      Volume: 23 Pages: 21-28

    • DOI

      10.3727/096504015x14424348426071

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of NF-κB and cellular invasion by novel flavonoid desmal in ovarian carcinoma cells.2016

    • Author(s)
      L. Wang, Y. Lin, K. Sidthipong, J. Tang, M. Li, T. Koyano, T. Kowithayakorn, K. Sumiyoshi, T. Ukaji, and K. Umezawa
    • Journal Title

      Heterocycles

      Volume: 92 Pages: 353-360

    • DOI

      10.3987/com-15-13386

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis2016

    • Author(s)
      M. El-Salhy and K. Umezawa
    • Journal Title

      International J. Mol. Med.

      Volume: in press

    • DOI

      10.3892/ijmm.2016.2560

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of NF-κB with dehydroxyepoxiquinomicin modifies function of human peritoneal mesothelial cells2016

    • Author(s)
      P. Sosinska, B. Mackowiak, R. Staniszewski, K. Umezawa and A. Breborowicz
    • Journal Title

      American Journal of Translational Research

      Volume: 8 Pages: 5756-5765

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of NF-κB activity enhances sensitivity to anticancer drugs in cholangiocarcinoma cells2016

    • Author(s)
      W. Seubwai, K. Vaeteewoottacharn, R. Kraiklang, K. Umezawa, S. Okada and S. Wongkham
    • Journal Title

      Oncology Research

      Volume: 23 Pages: 21-28

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of nuclear factor-κB signaling suppresses Spint-1-deletion-induced tumor susceptibility in the ApcMin/+ mode2016

    • Author(s)
      M. Kawaguchi, K. Yamamoto, A. Kanemaru, H. Tanaka, K. Umezawa, T. Fukushima, H. Kataoka
    • Journal Title

      Oncotarget 7 (42): 68614-68622, 2016

      Volume: 7 Pages: 68614-68622

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of NF-κB and cellular invasion by novel flavonoid desmal in ovarian carcinoma cells2016

    • Author(s)
      L. Wang, Y. Lin, K. Sidthipong, J. Tang, M. Li, T. Koyano, T. Kowithayakorn, K. Sumiyoshi, T. Ukaji, and K. Umezawa
    • Journal Title

      Heterocycles

      Volume: 92 Pages: 353-360

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] dentification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.2016

    • Author(s)
      S. Katsuyama, K. Sugino, Y. Sasazawa, Y. Nakano, H. Aono, K. Morishita, M. Kawatani, K. Umezawa, H. Osada and S. Simizu
    • Journal Title

      FEBS Lett

      Volume: 590 Pages: 1152-1162

    • DOI

      10.1002/1873-3468.12146

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-26750373, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16J40133, KAKENHI-PROJECT-16K01941
  • [Journal Article] nhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide2015

    • Author(s)
      N. Koide, A. Kaneda, T. Yokochi, K. Umezawa
    • Journal Title

      International Immunopharmacology

      Volume: VOL. 25 Pages: 162-168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines2015

    • Author(s)
      T. Toda, M. Watanabe, J. Kawato, M. Higashihara, T. Kunisada, K. Umezawa and R. Horie
    • Journal Title

      Br J Haematol.

      Volume: 170 Pages: 837-846

    • DOI

      10.1111/bjh.13508

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-26460439, KAKENHI-PROJECT-26460440
  • [Journal Article] Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells2015

    • Author(s)
      Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.
    • Journal Title

      Int. Arch. Allergy Immunol.

      Volume: 166 Pages: 84-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2015

    • Author(s)
      Matsui C, Ikeda Y, Iinuma H, Kushida N, Kunisada T, Simizu S, Umezawa K.
    • Journal Title

      J. Antibiot.

      Volume: 67 Pages: 787-790

    • DOI

      10.1038/ja.2014.63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] Inhibition of IGF-1-mediated cellular migration and invasion by migracin A in ovarian clear cell carcinoma cells.2015

    • Author(s)
      T. Ukaji, Y. Lin, K. Banno, S. Okada and K. Umezawa
    • Journal Title

      PLOS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0137663

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor–κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts2015

    • Author(s)
      S. Inokawa, T. Watanabe, H. Keino, Y. Sato, A. Hirakata, A. A. Okada, K. Fukuda, A. Fukushima, K. Umezawa
    • Journal Title

      Graefes Arch. Clin. Exp. Ophthalmol.

      Volume: VOL. 253 Pages: 557-563

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] C-mannosylation of human hyaluronidase 1: possible roles for secretion and enzymatic activity2015

    • Author(s)
      Goto, Y., Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S.
    • Journal Title

      Int. J. Oncol.

      Volume: 45 Pages: 344-350

    • DOI

      10.3892/ijo.2014.2438

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J04256, KAKENHI-PROJECT-24310167
  • [Journal Article] 3-[(dodecylthiocarbonyl)methyl]-glutarimide attenuates graft arterial disease by suppressing alloimmune responses and vascular smooth muscle cell proliferation.2015

    • Author(s)
      M. Zaitsu, K. Yamashita, S. Shibasaki, Y. Tsunetoshi, M. Fukai, M. Ogura, T. Yoshida, R. Igarashi, N. Kobayashi, K. Umezawa and S. Todo
    • Journal Title

      Transplantation

      Volume: 99 Pages: 948-956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] A nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates GVHD in allogeneic bone marrow transplantation.2015

    • Author(s)
      S. Yamanouchi, Y. Adachi, T. Shimo, K. Umezawa, M. Okigaki, S. Tsuji, M Li, J. Takaya, T. Kuge, S. Ikehara, K. Kaneko
    • Journal Title

      Immunobiology

      Volume: 220 Pages: 1059-1066

    • DOI

      10.1016/j.imbio.2015.05.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Conophylline Protects Cells in Cellular Models of Neurodegenerative Diseases by Inducing Mammalian Target of Rapamycin (mTOR)-independent Autophagy.2015

    • Author(s)
      Sasazawa Y, Sato N, Umezawa K, Simizu S.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 290 Pages: 6168-6178

    • DOI

      10.1074/jbc.m114.606293

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-26750373
  • [Journal Article] Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: involvement of positive feedback mechanism2015

    • Author(s)
      Kuboki M, Ito A, Simizu S, Umezawa K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 456 Pages: 810-814

    • DOI

      10.1016/j.bbrc.2014.12.024

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mTOR-independent autophagy2015

    • Author(s)
      Y. Sasazawa, N. Sato, K. Umezawa, S. Simizu
    • Journal Title

      J. Biol Chem.

      Volume: VOL. 290 Pages: 6168-6178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Activation of apoptosis by caspase-3-dependent specific RelB cleavage in anticancer agent-treated cancer cells: Involvement of positive feedback mechanism2015

    • Author(s)
      M. Kuboki, A. Ito, S. Simizu, K. Umezawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: VOL. 456 Pages: 810-814

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Inhibition of canonical NF-κB nuclear localization by (-)-DHMEQ via impairment of DNA binding2015

    • Author(s)
      K. Horie, J. Ma, K. Umezawa
    • Journal Title

      Oncology Research

      Volume: VOL. 22 Pages: 105-115

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer2015

    • Author(s)
      Y. Ito, E. Kikuchi, N. Tanaka, T. Kosaki, E. Suzuki, R. Mizuno, T. Shinojima, A. Miyajima, K. Umezawa and M. Oya
    • Journal Title

      BMC Cancer

      Volume: 15 Pages: 324-324

    • DOI

      10.1186/s12885-015-1315-9

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-26462429, KAKENHI-PROJECT-26750362
  • [Journal Article] Inhibition of MMP-2-mediated mast cell invasion by NF-κB inhibitor DHMEQ in mast cells2015

    • Author(s)
      N. Noma, M. Asagiri, M. Takeiri, S. Ohmae, K. Takemoto, K. Iwaisako, S. Simizu, K. Umezawa
    • Journal Title

      International Achieves of Allergy and Immunology

      Volume: VOL. 166 Pages: 84-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] DSE-FRET: A new anti-cancer drug screening assay for DNA binding proteins2014

    • Author(s)
      T. Miyagi, B. Shiotani, R. Miyoshi, T. Yamamoto, T. Oka, K. Umezawa, T. Ochiya, M. Takano and H. Tahara
    • Journal Title

      Cancer Science

      Volume: VOL. 105 Pages: 870-874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells2014

    • Author(s)
      T. Togano, M. Watanabe, K. Itoh, K. Umezawa, N. Masuda, M. Higashihara, R. Horie
    • Journal Title

      Lung Cancer

      Volume: VOL. 83 Pages: 139-145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor, (-)-DHMEQ2014

    • Author(s)
      M. Sato, K. Nakanishi, S. Haga, M. Fujiyoshi, M. Baba, K. Mino, Yimin, H. Niwa, H. Yokoo, K. Umezawa, Y. Ohmiya, T. Kamiyama, S. Todo, A. Taketomi, M. Ozaki
    • Journal Title

      Oncology Research

      Volume: VOL. 21 Pages: 333-343

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation2014

    • Author(s)
      M. Kamoshita, Y. Ozawa, S. Kubota, S. Miyake, C. Tsuda, N. Nagai, K. Yuki, S. Shimmura, K. Umezawa and K. Tsubota
    • Journal Title

      PLOS One

      Volume: VOL.9 Pages: 1-10

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Involvement of conserved tryptophan residues for secretion of TIMP-22014

    • Author(s)
      Ukaji, T., Sasazawa, Y., Umezawa, K. & Simizu, S.
    • Journal Title

      Oncology Letters

      Volume: 7 Pages: 631-634

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Journal Article] Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells2014

    • Author(s)
      M. Watanabe, K. Umezawa, M. Higashihara, R. Horie
    • Journal Title

      Oncology Research

      Volume: VOL. 21 Pages: 173-180

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2014

    • Author(s)
      C. Matsui, Y. Ikeda, H. Iinuma, N. Kushida, T. Kunisada, S. Simizu and K. Umezawa
    • Journal Title

      J. Antibiotics

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma2014

    • Author(s)
      M. Celegato, C. Borghese, K. Umezawa, N. Casagrande, A. Colombatti, A. Carbone, D. Aldinucci
    • Journal Title

      Cancer Letters

      Volume: VOL. 349 Pages: 26-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Immunosuppression through constitutively activated NF-κB signaling in human ovarian cancer and its reversal by a NF-κB inhibitor2014

    • Author(s)
      H. Nishio, T. Yaguchi, J. Sugiyama, H. Sumimoto, K. Umezawa, T. Iwata, N. Susumu, T.Fujii, N. Kawamura, A. Kobayashi, J-H Park, D. Aoki, Y. Kawakami
    • Journal Title

      British J. Cancer

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Poly (ADP-Ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells.2014

    • Author(s)
      N. Lampiasi, K.Umezawa, G. Montalto, M. Cervello
    • Journal Title

      BBA-Molecular Cell Research

      Volume: VOL. 1843 Pages: 2662-2673

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production2014

    • Author(s)
      C. Matsui, Y. Ikeda, H. Iinuma, N. Kushida, T. Kunisada, S. Simizu, K. Umezawa
    • Journal Title

      Journal of Antibiotics

      Volume: VOL. 67 Pages: 787-790

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells2014

    • Author(s)
      M. Watanabe, K. Umezawa, M. Higashihara and R. Horie
    • Journal Title

      Oncology Res.

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Amelioration of severe TNBS induced colitis by novel AP-1 and NF-κB inhibitors in rats.2014

    • Author(s)
      M. El-Salhy, K. Umezawa, O.-H. Gilja, J. G. Hatlebakk, D. Gundersen, T. Hausken
    • Journal Title

      The Scientific World

      Volume: VOL. 2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells2014

    • Author(s)
      T. Togano, M. Watanabe, K. Itoh, K. Umezawa, N. Masuda, M. Higashihara and R. Horie
    • Journal Title

      Lung Cancer

      Volume: 83 Pages: 139-145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma2014

    • Author(s)
      M. Celegato, C. Borghese, K. Umezawa, N. Casagrande, A. Colombatti, A. Carbone, and D. Aldinucci
    • Journal Title

      Cancer Letters

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy2014

    • Author(s)
      W. Seubwai, R. Kraiklang, K. Vaeteewoottacharn, K. Umezawa, S. Okada, S. Wongkham
    • Journal Title

      PLOS One

      Volume: VOL.9 Pages: 1-10

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Immunosuppression through constitutively activated NF-κB signaling in human ovarian cancer and its reversal by a NF-κB inhibitor2014

    • Author(s)
      H. Nishio, T. Yaguchi, J. Sugiyama, H. Sumimoto, K. Umezawa, T. Iwata, N. Susumu, T.Fujii, N. Kawamura, A. Kobayashi, J-H Park, D. Aoki, Y. Kawakami
    • Journal Title

      British Journal of Cancer

      Volume: VOL. 110 Pages: 2965-2974

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Novel approaches to target NF-κB and other signaling pathways in cancer stem cells2014

    • Author(s)
      T. Ukaji, K. Umezawa
    • Journal Title

      Advances in Biological Regulation

      Volume: VOL. 56 Pages: 108-115

    • Data Source
      KAKENHI-PROJECT-26350975
  • [Journal Article] Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor, (-)-DHMEQ2014

    • Author(s)
      M. Sato, K. Nakanishi, S. Haga, M. Fujiyoshi, M. Baba, K. Mino, Yimin, H. Niwa, H. Yokoo, K. Umezawa, Y. Ohmiya, T. Kamiyama, S. Todo, A. Taketomi and M. Ozaki
    • Journal Title

      Oncology Res.

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway2013

    • Author(s)
      A. Ogasawara, S. Simizu, A. Ito, T. Kawai, Y. Saisho, I. Takei and K. Umezawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 433 Pages: 181-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of Cancer cell invasion and metastasis by NF-kappa B inhibitors2013

    • Author(s)
      T. Ukaji, S. Gantsev and K. Umezawa
    • Journal Title

      Creative Surgery and Oncology 2013 (3)

      Volume: 3 Pages: 6-12

    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Combined effect of dehydroxymethylepoxyquinomicin and gemcitabine in a mouse model of liver metastasis of pancreatic cancer2013

    • Author(s)
      K. Suzuki, K. Aiura, S. Matsuda, O. Itano, O. Takeuchi, K. Umezawa, and Y. Kitagawa
    • Journal Title

      Clinical & Experimental Metastasis

      Volume: 30 Pages: 381-392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013

    • Author(s)
      Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
    • Journal Title

      J. Antibiot

      Volume: 66 Pages: 225-230

    • NAID

      10031168683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Determination of topological structure of ARL6ip1 in cells: Identification of the essential binding region of ARL6ip1 for conophylline2013

    • Author(s)
      Kuroda, M., Funasaki, S., Saitoh, T., Sasazawa, Y., Nishiyama, S., Umezawa, K. & Simizu, S.
    • Journal Title

      FEBS Letters

      Volume: 587 Pages: 3656-3660

    • DOI

      10.1016/j.febslet.2013.09.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310167, KAKENHI-PROJECT-24810025
  • [Journal Article] p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein2013

    • Author(s)
      T. Ohsugi, T. Ishida, T. Shimasaki, S. Okada and K. Umezawa
    • Journal Title

      Carcinogenesis

      Volume: 34 Pages: 2129-2136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] The efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: II. Induction DHMEQ treatment ameliorates subsequent allo-immune responses, and permits a long-2013

    • Author(s)
      Watanabe M, Y amashita K, Kamachi H, Kuraya D, Koshizuka Y, Shibasaki S, Asahi Y, Ono H, Emoto S, Ogura M, Y oshida T, Ozaki M, Umezawa K, Matsushita M, T odo S
    • Journal Title

      Transplantation

      Volume: 96(5) Pages: 454-462

    • DOI

      10.1097/tp.0b013e31829b077f

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390309
  • [Journal Article] Peritoneal NF-κB as a possible molecular target for suppression of various cancers and inflammation. (Review)2013

    • Author(s)
      K. Umezawa
    • Journal Title

      Forum of Immunopathological Diseases and Therapeutics

      Volume: 4 Pages: 63-77

    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp2013

    • Author(s)
      Y. Arai, H. Iinuma, Y. Ikeda, M. Igarashi, K. Hatano, N. Kinoshita, T. Ukaji, S. Simizu and K. Umezawa
    • Journal Title

      J. Antibiot.

      Volume: 66

    • NAID

      10031168683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of cancer cell invasion and metastasis by NF-kappa B inhibitors. (Review)2013

    • Author(s)
      T. Ukaji, S. Gantsev and K. Umezawa
    • Journal Title

      Creative Surgery and Oncology

      Volume: 3 Pages: 6-12

    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] The efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: I. HMGB1 suppression by DHMEQ prevents early islet graft damage.2013

    • Author(s)
      Kuraya D, Watanabe M, Koshizuka Y, Ogura M, Y oshida T, Asahi Y, Kamachi H, Nakamura T, Harashima H, Ozaki M, Umezawa K, Matsushita M, Y amashita K, T odo S
    • Journal Title

      Transplantation

      Volume: 96(5) Pages: 445-53

    • DOI

      10.1097/tp.0b013e31829b0744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390309
  • [Journal Article] Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF- κB suppression via reactive oxygen species and unfolded protein response2013

    • Author(s)
      S. Nakajima, H. Kato, L. Gu, S. Takahashi, H. Johno, K. Umezawa and M. Kitamura
    • Journal Title

      J. Immunol.

      Volume: 190 Pages: 6559-6569

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Synergistic effect of 5-azacytidine and NF-kappa B inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells2013

    • Author(s)
      T. Togano, M. Nakashima, M. Watanabe, K. Umezawa, T. Watanabe, M. Higashihara and R. Horie
    • Journal Title

      Oncology Res.

      Volume: 20 Pages: 571-577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] The novel NF-κB inhibitor DHMEQ synergizes with Celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism2012

    • Author(s)
      N. Lampiasi, A. Azzolina1, K Umezawa, G. Montalto, J. A. McCubrey and M. Cervello
    • Journal Title

      Cancer Lett.

      Volume: 322 Pages: 35-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of cellular invasion and induction of anoikis in mouse melanoma cells by an anti-inflammatory agent DTCM-glutarimide2012

    • Author(s)
      A. Kaneda, S. K. Gantsev and K. Umezawa
    • Journal Title

      Creative Surgery and Oncology

      Volume: 2012 Pages: 4-9

    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via NFκB pathway on advanced-stage epithelial ovarian cancer2012

    • Author(s)
      C. Alberti, P. Pinciroli, B. Valeri, R. Ferri, A. Ditto, K. Umezawa, M. L. Sensi, S. Canevari, and A. Tomassetti
    • Journal Title

      Oncogene

      Volume: 31 Pages: 4139-4149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Novel approaches to target cancer initiating cells-Eliminating the root of the cancer2012

    • Author(s)
      J.A.McCubrey, K.Umezawa, et al
    • Journal Title

      Advances in Enzyme Regulation

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] The immunomodulatory effect of nuclear factor-κB inhibition by dehydroxymethylepoxyquinomicin in combination with donor-specific blood transfusion2012

    • Author(s)
      R.Goto, K.Umezawa, M.Ozaki, et al
    • Journal Title

      Transplantation

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of nuclear factor-jB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells2012

    • Author(s)
      A.M.Castro-Gamero, K.Umezawa, et al
    • Journal Title

      Anti-Cancer Drugs

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by proinflammatory cytokines derived from RAW 264.7 macrophage cells2012

    • Author(s)
      M.Kawata, K.Umezawa, et al
    • Journal Title

      J.Biochem.

      Volume: (in press)

    • NAID

      10031166059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012

    • Author(s)
      T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
    • Journal Title

      FEBS Lett.

      Volume: 586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice.2012

    • Author(s)
      T.Funakoshi, M.Ozaki, K.Umezawa, et al
    • Journal Title

      Journal of Crohn's and Colotis

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      M.Takeiri, K.Umezawa, et al
    • Journal Title

      Org.Biomol.Chem.

      Volume: 10 Pages: 3053-3059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of cellular invasion and induction of anoikis in mouse melanoma cells by an anti-inflammatory agent DTCM-glutarimide2012

    • Author(s)
      A. Kaneda, S. K. Gantsev and K. Umezawa
    • Journal Title

      Creative Surgery and Oncology 2012

      Pages: 4-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Determination of the absolute structure of (+)-akaterpin2012

    • Author(s)
      H.Hosoi, K.Umezawa, et al
    • Journal Title

      Chem.Pharm.Bull.

      Volume: 60 Pages: 137-143

    • NAID

      130001852337

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells2012

    • Author(s)
      T. Yasukagawa, Y. Niwa, S. Simizu and K. Umezawa
    • Journal Title

      FEBS Lett

      Volume: 586 Pages: 1504-1509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by proinflammatory cytokines derived from RAW 264.7 macrophage cells2012

    • Author(s)
      M. Kawata, D. Koinuma, T. Ogami, K. Umezawa, C. Iwata, T. Watabe and K. Miyazono
    • Journal Title

      J. Biochem.

      Volume: 151 Pages: 205-216

    • NAID

      10031166059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced breast cancer cell adhesion2012

    • Author(s)
      Noma, N., Simizu, S., Kambayashi, Y., Kabe, Y., Suematsu, M. & Umezawa, K
    • Journal Title

      Oncology Reports

      Volume: 27 Pages: 2080-2084

    • DOI

      10.3892/or.2012.1733

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20113008, KAKENHI-PROJECT-23310163
  • [Journal Article] Antitumor effect of dehydroxymethylepoxyquinomicin (DHMEQ), a small molecule inhibitor of nuclear factor-κB, on glioblastoma2012

    • Author(s)
      T.Fukushima, K.Umezawa, et al
    • Journal Title

      Neuro-Oncology

      Volume: 14 Pages: 19-28

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
    • Journal Title

      Org. Biomol. Chem

      Volume: 10 Pages: 3053-3059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Suppression of inflammatory cytokine secretion by an NF-κB inhibitor in nasal polyps fibroblasts2012

    • Author(s)
      F. C.P. Valera, K. Umezawa, M. S. Brassesco, A. M. C. Gamero, R. G. P. Queiro, C. A. Scrideli, L. G. Tone, W. T. Anselmo-Lima
    • Journal Title

      Cellular Physiology and Biochemistry

      Volume: 30 Pages: 13-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats2012

    • Author(s)
      R.Saito, K.Umezawa, et al
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 621-630

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] A chemo-enzymatic expeditious route to racemic dihexanoyl (2R*,3R*,4R*)-dehydroxymethylepoxyquinomycin (DHMEQ), the precursor for lipase-catalyzed synthesis of the potent NF-κB Inhibitor, (2S,3S,4S)-DHMEQ2012

    • Author(s)
      R. Kobayashi, K. Hanaya, M. Shoji, K. Umezawa and T. Sugai
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 60 Pages: 1220-1223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Structure-activity relationship Of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012

    • Author(s)
      M.Takeiri, S.Simizu, K.Umezawa, et al
    • Journal Title

      Oncology Res.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer2012

    • Author(s)
      K. Hinohara, S. Kobayashi, S. Simizu, K. Tada, E. Tsuji, K. Nishioka, K. Umezawa, M. Mori, H. Kanauchi, T. Ogawa, J. Inoue, A. T and N. Gotoh
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Pages: 6584-6589

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of NF-κB-mediated expression of galectin-3-binding protein in tumor necrosis factor-α-induced breast cancer cell adhesion2012

    • Author(s)
      N. Noma, S. Simizu, Y. Kambayashi, Y. Kabe, M. Suematsu, and K. Umezawa
    • Journal Title

      Oncology Reports

      Volume: 27 Pages: 2080-2084

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB2012

    • Author(s)
      M. Takeiri, K. Horie, D. Takahashi, M. Watanabe, R. Horie, S. Simizu and K. Umezawa
    • Journal Title

      Org. Biomol. Chem.

      Volume: 10 Pages: 3053-3059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Structure-activity relationship of 9-methylstreptimidone that induces selective apoptosis in adult T-cell leukemia cells2012

    • Author(s)
      M. Takeiri, E. Ota, S. Nishiyama, H. Kiyota, S. Simizu and K. Umezawa
    • Journal Title

      Oncology Res.

      Volume: 20 Pages: 7-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Enhancement of radiosensitivity by a unique novel NF-κB inhibitor, DHMEQ, in prostate cancer2012

    • Author(s)
      N. Kozakai, E. Kikuchi, M. Hasegawa, E. Suzuki, H. Ide, A. Miyajima, Y. Horiguchi, J. Nakashima, K. Umezawa, N. Shigematsu and M. Oya
    • Journal Title

      British J. Cancer

      Volume: 107 Pages: 652-657

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells2012

    • Author(s)
      A. M. Castro-Gamero, K. S. Borgesa, V. da Silva Silveira, R. C. P. Lira, R. de Paula G. Queiroz, F. C. P. Valera, C. A. Scrideli, K. Umezawa and L. G. Tone
    • Journal Title

      Anti-Cancer Drugs

      Volume: 2012 Pages: 638-650

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] ErbB/NFkB signaling controls self-renewal of breast cancer stem cells2012

    • Author(s)
      K.Hinohara, K.Umezawa, et al
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Suppression of inflammatory cytokine secretion by an NF-κB inhibitor in nasal polyps fibroblasts2012

    • Author(s)
      F.C.P.Valera, K.Umezawa, et al
    • Journal Title

      Cellular Physiology and Biochemistry

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] The novel NF-kB inhibitor DHMEQ synergizes with Celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism2012

    • Author(s)
      N.Lampiasi, K Umezawa, et al
    • Journal Title

      Cancer Lett.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice2012

    • Author(s)
      T. Funakoshi, K. Yamashita, N. Ichikawa, M. Fukai, T. Suzuki, R. Goto, T. Oura, N. Kobayashi, T. Katsurada, S. Ichihara, M. Ozaki, K. Umezawa, and Satoru Todo
    • Journal Title

      Journal of Crohn’s and Colotis

      Volume: 5 Pages: 215-225

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via NFκB pathway on advanced-stage epithelial ovarian cancer2012

    • Author(s)
      C.Alberti, K.Umezawa, et al
    • Journal Title

      Oncogene

      Volume: (in press)

    • DOI

      10.1038/onc.2011.572

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] 新しいNF-κB阻害剤DHMEQの生物有機化学と抗炎症・抗がん剤への展望2011

    • Author(s)
      梅澤一夫、須貝威
    • Journal Title

      化学と生物

      Volume: 49 Pages: 406-414

    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Chemoenzymatic synthesis of (2R,3R,4R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf22011

    • Author(s)
      Y.Niitsu, K.Umezawa, et al
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Pages: 4635-4641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway2011

    • Author(s)
      K.Kobayashi, K.Umezawa, et al
    • Journal Title

      Biology of Reproduction

      Volume: 84 Pages: 248-254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Possible role of peritoneal NF-κB in peripheral inflammation and cancer : Lessons from the inhibitor DHMEQ2011

    • Author(s)
      K.Umezawa
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: 65 Pages: 252-259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Synthesis and biological evaluation of molecular probes based on the 9-methylstr eptimidone derivative DTCM-glutarimide2011

    • Author(s)
      E.Ota, K.Umezawa, et al
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 22 Pages: 164-167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion2011

    • Author(s)
      K.Mino, M.Ozaki, K.Umezawa, et al
    • Journal Title

      Cancer Science 102 : 1052-1058

      Volume: 102 Pages: 1052-1058

    • NAID

      10029293761

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion2011

    • Author(s)
      K. Mino, M. Ozaki, K. Nakanishi, S. Haga, M. Sato, M. Kina, M. Takahashi, N. Takahashi, A. Kataoka, K. Yanagihara, T. Ochiya, T. Kamiyama, K. Umezawa and S. Todo
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 1052-1058

    • NAID

      10029293761

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Synthesis and determination of the relative structure of akaterpin, a potent inhibit or of PI-PLC2011

    • Author(s)
      H.Hosoi, K.Umezawa, et al
    • Journal Title

      Tetrahedron Letters

      Volume: 52 Pages: 4961-4964

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components., 20112011

    • Author(s)
      T.Saitoh, K.Umezawa, et al
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 21 Pages: 6293-6296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] 新しいNF-κB阻害剤DHMEQの生物有機化学と抗炎症・抗がん剤への展望2011

    • Author(s)
      須貝威、梅澤一夫
    • Journal Title

      化学と生物

      Volume: (掲載確定)

    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Role of NF-κB/Snail/RKIP loop in the response of tumor cells to photodynamic therapy2011

    • Author(s)
      V.Rapozzi, K.Umezawa, et al
    • Journal Title

      Lasers in Surgery and Medicine 2011

      Volume: 43 Pages: 575-585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Suppression of erosive arthritis by NF-κB Inhibitors2011

    • Author(s)
      T.Kubota, K.Umezawa
    • Journal Title

      Current Rheumatology Reviews

      Volume: 7 Pages: 275-281

    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α2011

    • Author(s)
      K.Tsumura, K.Umezawa, et al
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Pages: 6357-6366

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Placenta growth factor induces melanoma resistance to temozolomide through a mechanism that involves the activation of the transcription factor NF-κB2011

    • Author(s)
      L.Levati, K.Umezawa, et al
    • Journal Title

      International J.Oncol.

      Volume: 38 Pages: 241-247

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone2011

    • Author(s)
      M.Takeiri, M.Ozaki, K.Umezawa, et al
    • Journal Title

      Inflammation Research

      Volume: 60 Pages: 879-888

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Coffee induces breast cancer resistance protein expression in Caco-2 cells2011

    • Author(s)
      M.Isshiki, K.Umezawa, et al
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 34 Pages: 1624-1627

    • NAID

      130001086598

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] Possible role of peritoneal NF-κB in peripheral inflammation and cancer : Lessons from the inhibitor DHMEQ.2011

    • Author(s)
      K.Umezawa
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: (掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Regulation of human dendritic cells by a novel specific nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin.2010

    • Author(s)
      K.Shinoda, K.Umezawa, et al
    • Journal Title

      Human Immunology

      Volume: 71 Pages: 763-770

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Efficient cellular uptake of the novel NF-κB inhibitor (-)-DHMEQ and irreversible inhibition of NF-κB in neoplastic cells2010

    • Author(s)
      C.Shimada, K.Umezawa, et al
    • Journal Title

      Oncology Research

      Volume: 18 Pages: 529-535

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Characterizing the involvement of the nuclear factor-kappa B (NFκB) transcription factor in uveal melanoma.2010

    • Author(s)
      R.Dror, K.Umezawa, et al
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 58 Pages: 1811-1816

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Donor pretreatment with DHMEQ improves islet transplantation.2010

    • Author(s)
      T.Takahashi, K.Umezawa, et al
    • Journal Title

      Journal of Surgical Research

      Volume: 163 Pages: 23-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion.2010

    • Author(s)
      N.Miyanishi, K.Banno, K.Umezawa, et al
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 403 Pages: 154-159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Nuclear factor-κB inhibitor, dehydroxy methyl epoxyquinomicin ameliorates experimental autoimmune uveoreitnitis(EAU)in mice2010

    • Author(s)
      D.Iwata, K.Umezawa, et al
    • Journal Title

      Investigative Ophthalmology & Visual Science 51

      Pages: 2077-2084

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Potent cytotoxic effect of a novel nuclear factor-kappa B inhibitor on human bladder cancer cells producing various cytokines.2010

    • Author(s)
      K.Kodaira, K.Umezawa, et al
    • Journal Title

      Urology

      Volume: 75 Pages: 805-812

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells2010

    • Author(s)
      M.Murohashi, K.Umezawa, et al
    • Journal Title

      British J.Cancer 102

      Pages: 206-212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Topical application of DHMEQ improves allergic inflammation via NF-κB inhibition.2010

    • Author(s)
      A.Hamasaka, K.Umezawa, et al
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 126 Pages: 400-403

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] A novel NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.2010

    • Author(s)
      T.Saitoh, K.Umezawa, et al
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 5638-5642

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Dehydroxyquinomicin inhibits expression and production of inflammatory mediators in interleukin-1β-induced human chondrocytes.2010

    • Author(s)
      V.Cardile, K.Umezawa, et al
    • Journal Title

      Cellular Physiology and Biochemistry

      Volume: 25 Pages: 543-550

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Dehydroxyquinomicin, a novel NF-kappaB inhibitor, prevents inflammatory injury induced by IFN-γ and histamine in keratinocytes NCTC 2544.2010

    • Author(s)
      V.Cardile, K.Umezawa, et al
    • Journal Title

      Cellular and Experimental Pharmacology and Physiology

      Volume: 37 Pages: 679-683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Design, synthesis, and biological evaluation of novel estradiol-bisp hosphonate conjugates as bone-specific estrogens2010

    • Author(s)
      M.Morioka, K.Umezawa, et al
    • Journal Title

      Bioorg.Med.Chem. 11

      Pages: 1143-1148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Chemoenzymatic synthesis of (2S,3S,4S)-form2010

    • Author(s)
      M. Hamada, Y. Niitsu, C. Hiraoka, I. Kozawa, T. Higashi, M. Shoji, K. Umezawa, T. Sugai
    • Journal Title

      the physiologically active stereoisomer of dehydroxymethylepoxyquinomicin (DHMEQ), a potent inhibitor on NF-κB. Tetrahedron 66

      Pages: 7083-7087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Chemoenzymatic synthesis of (2S,3S,4S)-form, the physiologically active stereoisomer of dehydroxymethylepoxyquinomicin (DHMEQ), a potent inhibitor on NF-κB.2010

    • Author(s)
      M.Hamada, T.Sugai, K.Umezawa, et al
    • Journal Title

      Tetrahedron

      Volume: 66 Pages: 7083-7087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Promotion of β-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells2010

    • Author(s)
      M.Kawakami, K.Umezawa, et al
    • Journal Title

      Biomedicine & Pharmacotherapy 64

      Pages: 226-231

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Inhibition of active HIV-1 replication by NF-κB inhibitor DHMEQ.2010

    • Author(s)
      A.Miyake, K.Umezawa, et al
    • Journal Title

      Microbes and Infection

      Volume: 12 Pages: 400-408

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion.2010

    • Author(s)
      N. Miyanishi, Y. Suzuki, S. Simizu, Y. Kuwabara, K. Banno. K. Umezawa
    • Journal Title

      Biochem.Biophys.Res.Commun. 403

      Pages: 154-159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Unusual intramolecular N→O acyl group migration occurring during conjugation of(-)-DHMEQ with cysteine2009

    • Author(s)
      I.Kozawa, K.Umezawa, et al
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 5380-5382

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome. An attractive target for the NF-κB-specific inhibitor DHMEQ.2009

    • Author(s)
      Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N, Umezawa K.
    • Journal Title

      Ann N Y Acad Sci 1173

      Pages: 137-145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591165
  • [Journal Article] Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor (-)-DHMEQ.2009

    • Author(s)
      E. Suzuki, Y. Ninomiya, K. Umezawa
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 379-383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Inhibition of inflammatory mediator secretion by(-)-DHMEQ in mouse bone marrow-derived macrophages2009

    • Author(s)
      E.Suzuki, K.Umezawa, et al
    • Journal Title

      Biomed.Pharmacother 63

      Pages: 351-358

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Possible involvement of chemokine-induced platelet activation in throm bophilic diathesis of antiphospholipid syndrome : an attractive target for the NF-kB-specific inhibitor DHMEQ.2009

    • Author(s)
      T. Kubota, K. Umezawa, et al
    • Journal Title

      Ann. N. Y. Acad. Sci. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress.2009

    • Author(s)
      J. Inumaru, K. Umezawa, et al
    • Journal Title

      Genes Cells 14(in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Antitumor effects of DHMEQ, a novel NF-κB inhibitor, in human liver cancer cells is mediated through a reactive oxygen species-dependent mechanism2009

    • Author(s)
      N.Lampiasi, K.Umezawa, et al
    • Journal Title

      Molecular Pharmacology 76

      Pages: 290-300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Unusual intramolecular N>O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine.2009

    • Author(s)
      I. Kozawa, K. Kato, T. Teruya, K. Suenaga, K. Umezawa
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 5380-5382

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome.An attractive target for the NF-κB-specific inhibitor DHMEQ.2009

    • Author(s)
      Kubota T, Fukuya Y, Hashimoto R, Kanda T, Suzuki H, Okamura Y, Nanki T, Miyasaka N, Umezawa K.
    • Journal Title

      Ann N Y Acad Sci 1173巻

      Pages: 137-145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591165
  • [Journal Article] Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor(-)-DHMEQ2009

    • Author(s)
      E.Suzuki, K.Umezawa, et al
    • Journal Title

      Biochem.Biophys.Res.Commun 379

      Pages: 379-383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Transient inhibition of NF-κB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation2009

    • Author(s)
      N.Dabaghmanesh, K.Umezawa, et al
    • Journal Title

      Cancer Science 100

      Pages: 737-746

    • NAID

      10025144771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Synthesis and biological evaluation on novel analogs of 9-methyl-streptimidone, an inhibitor of NF-κB.Bioorg2009

    • Author(s)
      Y.Ishikawa, K.Umezawa, et al
    • Journal Title

      Med.Chem.Lett 19

      Pages: 1726-1728

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Efficient synthesis of(±)-parasitenone, a novel inhibitor of NF-κB.2009

    • Author(s)
      T.Saitoh, K.Umezawa, et al
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 5383-5386

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Enzyme-catalyzed resolution of 3, 8-dioxatricyclo[3.2.1.02, 4]octane-6-carboxylic esters and the application to the synthesis of 3-epishikimic acid.2009

    • Author(s)
      M.Hamada, K.Umezawa, et al
    • Journal Title

      Tetrahedron : Asymmetry 20

      Pages: 2105-2111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Induction of oncogene addiction shift to NF-κB by camptothecin in solid tumor cells2009

    • Author(s)
      T.Togano, K.Umezawa, et al
    • Journal Title

      Biochem.Biophys.Res.Commun. 390

      Pages: 60-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Antidiabetic effect of plant extract containing conophylline by oral administration in streptozotocin-treated and Goto-Kakizaki rats2009

    • Author(s)
      M.Fujii, K.Umezawa, et al
    • Journal Title

      Biomedicine &.Pharmacotherapy 63

      Pages: 710-716

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells2009

    • Author(s)
      N.Tsukamoto, K.Umezawa, et al
    • Journal Title

      Clin.Cancer Res. 15

      Pages: 5733-5743

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress2009

    • Author(s)
      J.Inumaru, K.Umezawa, et al
    • Journal Title

      Genes Cells 14

      Pages: 706-716

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Preparation of conophylline affinity nanobeads and identification of a target protein2009

    • Author(s)
      E.Suzuki, K.Umezawa, et al
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 6185-6195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Target-selective degradation of cancer-related proteins by novel photosensitizers for molecular-targeted photodynamic therapy2009

    • Author(s)
      K.Toshima, K.Umezawa, et al
    • Journal Title

      (Review article)Cancer Science 100

      Pages: 1581-1584

    • NAID

      10027194039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.2008

    • Author(s)
      S. Baritaki, K. Umezawa, et al
    • Journal Title

      J. Immunol. 180

      Pages: 6199-6210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues.2008

    • Author(s)
      M. Yamamoto, K. Umezawa, et al
    • Journal Title

      J. Med. Chem. 51

      Pages: 5780-5788

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] The NF-κB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs.2008

    • Author(s)
      M. I. Vega, K. Umezawa, et al
    • Journal Title

      Leukemia and Lymphoma 49

      Pages: 1982-1994

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] The novel NF-kB inhibitor, Dehydroxymethylepoxyquinomi-cin (DHMEQ) prevents local and remote organ injury following intestinal ischemia/ reperfusion in rats2008

    • Author(s)
      Tomomi Suzuki, Hiroyuki Furukawa, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo et. al.
    • Journal Title

      Journal of Surgical Research 149

      Pages: 69-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Journal Article] NF-κBを標的とする抗癌剤2008

    • Author(s)
      鈴木絵里子、梅澤一夫
    • Journal Title

      医学のあゆみ 244

      Pages: 65-69

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Effects of DHMEQ, a novel nuclear factor-kB inhibitor on beta cell dysfunction in INS cells.2008

    • Author(s)
      Y. Saisho, K. Umezawa, et al
    • Journal Title

      Endocrine J. 55

      Pages: 433-438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Identification of the RelA domain responsible for action of a new NF-kB inhibitor DHMEQ.2008

    • Author(s)
      M. Watanabe, K. Umezawa, et al
    • Journal Title

      Biochem. Biophys. Res. Commun. 376

      Pages: 310-314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues.2008

    • Author(s)
      M. Yamamoto, R. Horie, M. Takeiri, I. Kozawa, K. Umezawa
    • Journal Title

      J.Med.Chem. 51

      Pages: 5780-5788

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells.2008

    • Author(s)
      C. Nishioka, K. Umezawa, et al
    • Journal Title

      Immunology 124

      Pages: 198-205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts.2008

    • Author(s)
      S. Makino, K. Umezawa, et al
    • Journal Title

      J. Dermatol. Sci. 51

      Pages: 171-180

    • NAID

      10024298393

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.2008

    • Author(s)
      Z. Meng, K. Umezawa, et al
    • Journal Title

      Endocrinology 149

      Pages: 5357-5365

    • NAID

      120006982281

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] The novel NF-kB activation inhibitor dehydroxymethyl-epoxyquinomicin suppresses anti-Thyl. 1-induced glomerulonephritis in rats.2008

    • Author(s)
      T. Kosaka, K. Umezawa, et al
    • Journal Title

      Nephron Exp. Nephrol. 110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kB inhibitor, Dehydroxymethylepoxyquinomicin (DHMEQ).2008

    • Author(s)
      K. Horiuchi, K. Umezawa, et al
    • Journal Title

      Cancer Letters 272

      Pages: 336-344

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kB inhibitor DHMEQ.2008

    • Author(s)
      A. Miyake, K. Umezawa, et al
    • Journal Title

      Microbes and Infection 10

      Pages: 748-756

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] The novel NF-kappa B inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reper fusion in rats.2008

    • Author(s)
      T. Suzuki, K. Umezawa, et al
    • Journal Title

      J. Surg. Res. 149

      Pages: 69-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Inhibition of tumor angiogenesis by targeting endotheliai ATP synthase with sangivamycin.2007

    • Author(s)
      Y. Komi, K. Umezawa, et al.
    • Journal Title

      Japan Journal of Clinical Oncology 37

      Pages: 867-873

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines : Involvement in chemosensitization to drug-induced apoptosis2007

    • Author(s)
      E. Suzuki, K. Umezawa, et al.
    • Journal Title

      Oncogene 26

      Pages: 6184-6189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] IκBα independent induction of NF-κB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells.2007

    • Author(s)
      M. Watanabe, K. Umezawa, et al.
    • Journal Title

      Laboratory Investigation 87

      Pages: 372-382

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Conophylline and betacellulin-δ4 : an effective combination of differentiation factors for pancreatic β cells.2007

    • Author(s)
      R. Kitamura, K. Umezawa, et al.
    • Journal Title

      Endocline J 54

      Pages: 255-264

    • NAID

      10019478673

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Reversal of resistance to cytotoxic cancer therapies : DHMEQ as a chemo-sensitizing and immuno-sensitizing agent.2007

    • Author(s)
      A. Katsman, K. Umezawa, et al.
    • Journal Title

      Drug Resistance Updates 10

      Pages: 1-12

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] NF-κB inhibitorDHMEQ suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANCL, OPG or M-CSF.2007

    • Author(s)
      T. Kubota, K. Umezawa, et al.
    • Journal Title

      Arthritis Research & Therapy 9/5/R97(Open Access)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Targeting NF-κB and induction of apoptosis by novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells.2007

    • Author(s)
      N. Kimura, K. Umezawa, et al.
    • Journal Title

      Leukemia Research 31

      Pages: 6184-6189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Tyrosine kinase inhibitor methyl-2,5-dihydroxycinnamate induces PML nuclear body formation and apoptosis in tumor cells.2007

    • Author(s)
      N. Komura K. Umezawa, et al.
    • Journal Title

      Exp. Cell Res. 313

      Pages: 2753-2765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor.2007

    • Author(s)
      N. Komura, K. Umezawa, et al.
    • Journal Title

      Leuk. Res. 31

      Pages: 301-313

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin2007

    • Author(s)
      Shinya Ueki, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo et. al.
    • Journal Title

      Transplantation 82(12)

      Pages: 1720-1727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Journal Article] 炎症を抑制する生理活性物質の探索2007

    • Author(s)
      梅澤一夫
    • Journal Title

      蛋白質 核酸 酵素 52, No.13

      Pages: 1685-1689

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with Tax-deficient adult T-cell leukemia-derived cell lines.2007

    • Author(s)
      T. Ohsugi, K. Umezawa, et al.
    • Journal Title

      Cancer Letters 257

      Pages: 206-215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.2007

    • Author(s)
      Y. N. Kimura, K. Umezawa, et al.
    • Journal Title

      Cancer Science 98

      Pages: 2009-2018

    • NAID

      10019996850

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor.2007

    • Author(s)
      N.Komura, K.Umezawa, et al.
    • Journal Title

      Leuk. Res. 31

      Pages: 301-313

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Suppression of diabetes-induced retinal inflammation by blocking angiotensin II type 1 receptor or its downstream NF-κB pathway.2007

    • Author(s)
      N. Nagai, K. Umezawa, et al.
    • Journal Title

      Investigative Ohthalmology and Visual Science 48

      Pages: 4342-4350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Inhibition of NF kappa B activation by 9-methylstreptimidone isolated from Streptomyces.2006

    • Author(s)
      Z.Wang, K.Umezawa, et al.
    • Journal Title

      Heterocycles 69

      Pages: 377-383

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Control of allograft rejection by applying a novel NF-kB inhibitor, dehydroxymethylepoxyquinomicin.2006

    • Author(s)
      Shinya Ueki, Kenichiro Yamashita, Takeshi Aoyagi, Sanae Haga, Tomomi Suzuki, Tomoo Itoh, Masahiko Taniguchi, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
    • Journal Title

      Transplantation 82・12

      Pages: 1720-1727

    • Data Source
      KAKENHI-PROJECT-18209041
  • [Journal Article] Inhibition of Tipopolysaccharide activity by a bacterial cyclic lipopeptide surfactin.2006

    • Author(s)
      T.Takahashi, K.Umezawa, et al.
    • Journal Title

      J. Antibiot 59

      Pages: 35-43

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Conophylline : A novel differentiation inducer for pancreatic β cells.2006

    • Author(s)
      I.Kojima, K.Umezawa
    • Journal Title

      Int. J. Biochem. 38

      Pages: 923-930

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Survivin associates with cell proliferation in renal cancer cells : Regulation of surviving expression by insulin-like growth factor-1, interferon-γ and a novel NF-κB inhibitor.2006

    • Author(s)
      A.Sato, K.Umezawa, et al.
    • Journal Title

      Int. J. Oncology 28

      Pages: 841-846

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Inhibition of tumor growth by NF-κB inhibitors.2006

    • Author(s)
      K.Umezawa
    • Journal Title

      Cancer Science 97

      Pages: 990-995

    • NAID

      10019377732

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] BRAFV600E promotes invasiveness of thyroid cancer cells through NF-κB activation.2006

    • Author(s)
      I.Palona, K.Umezawa, et al.
    • Journal Title

      Endocrinology 147

      Pages: 5699-5707

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Effects of a novel NF-κB inhibitor, dehydroxymethyepoxyquinomicin (DHMEQ), on growth, apoptosis gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines.2006

    • Author(s)
      H.Ruan, K.Umezawa, et al.
    • Journal Title

      Leukemia 20

      Pages: 800-806

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Inhibition of Lipopolysaccharide Activity a Bacterial Cyclic Lipopeptide Surfactin2006

    • Author(s)
      Taichi Takahashi, Osamu Ohno, Yoko Ikeda, Ryuichi Sawa, Yoshiko Homma, Masayuki Igarashi, Kazuo Umezawa
    • Journal Title

      The Journal of Antibiotics 59・1

      Pages: 35-43

    • NAID

      10017147139

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510187
  • [Journal Article] ケミカルパソロシーによる病態解析と薬剤開発。2006

    • Author(s)
      梅澤一夫
    • Journal Title

      現代化学2006年7月号 No.424

      Pages: 38-42

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Blocking NF-κB as a potential strategy to treat adult T-cell leukemia/lymphoma.2006

    • Author(s)
      R.Horie, K.Umezawa, et al.
    • Journal Title

      Drug News Persrect. 19

      Pages: 201-209

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Inhibition of Lipopolysaccharide Activity by a Bacterial Cyclic Lipopeptide Surfactin2006

    • Author(s)
      T.Takahashi, O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, K.Umezawa
    • Journal Title

      The Journal of Antibiotics 59・1

      Pages: 35-43

    • NAID

      10017147139

    • Data Source
      KAKENHI-PROJECT-15510187
  • [Journal Article] In vitro and in vivo antitumor activity of the NF-kappa B inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.2006

    • Author(s)
      T.Ohsugi, K.Umezawa, et al.
    • Journal Title

      Leuk. Res. 30

      Pages: 90-97

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] DHMEQ, a new NF-κB inhibitor, induces apoptosis and enhances fludarabine effects on chronic lymphocytic leukemia cells.2006

    • Author(s)
      R.Horie, K.Umezawa, et al.
    • Journal Title

      Leukemia 20

      Pages: 800-806

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] 転写因子NF-κBと癌の進展。2006

    • Author(s)
      梅澤一夫
    • Journal Title

      バイオサイエンスとインダストリー 64 (No.4)

      Pages: 224-225

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Inhibition of macrophage activation and phagocytosis by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin.2006

    • Author(s)
      E.Suzuki, K.Umezawa
    • Journal Title

      Biomed. Pharmacother. 60

      Pages: 578-586

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethylepoxyquinonicin.2006

    • Author(s)
      S.Ueki, K.Umezawa, et al.
    • Journal Title

      Transplantation 82

      Pages: 1720-1727

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Adrenaline contributes to prenatal respiratory maturation in rat medulla-spinal cord preparation.2006

    • Author(s)
      M.Fujii, K.Umezawa, et al.
    • Journal Title

      Brain Res. 1090

      Pages: 45-50

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.2005

    • Author(s)
      Kuroda K, Horiguchi Y, Nakashima J, Kikuchi E, Kanao K, Miyajima A, Ohigashi T, Umezawa K, Murai M
    • Journal Title

      Clin. Cancer Res. 11

      Pages: 5590-5594

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390469
  • [Journal Article] Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis.2005

    • Author(s)
      C.Culmsee, K.Umezawa, et al.
    • Journal Title

      Molecular Pharmacology 68

      Pages: 1006-1017

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Targeting of NF-κB pathways by DHMEQ, a novel inhibitor of breast carcinomas : Anti-tumor and anti-angiogenic activity in vivo2005

    • Author(s)
      G.Matsumoto, J.Namekawa, M.Muta, T.Nakamura, H.Bando, K.Tohyama, M.Toi, K.Umezawa
    • Journal Title

      Clin.Cancer Res. 11

      Pages: 1287-1293

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Dopamine desynchronizes the pace-making neuronal zctivity of rat respiratory rhythm generation.2005

    • Author(s)
      M.Fujii, K.Umezawa, et al.
    • Journal Title

      Eur. J. Neurosci. 23

      Pages: 1015-1027

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] A novel NF-κB inhibitor DHMEQ selectively targets constitutive NF-κB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo2005

    • Author(s)
      M.Watanabe, M.Z.Dewan, T.Okamura, M.Sasaki, K.Itoh, M.Higashihara, H.Mizoguchi, M.Honda, T.Sata, T.Watanabe, N.Yamamoto, K.Umezawa, R.Horie
    • Journal Title

      Int.J.Cancer 114

      Pages: 32-38

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Dopaminergic effects on respiratory rhythm generation in rat brainstem-spinal cord preparation2005

    • Author(s)
      M.Fujii, K.Umezawa, A.Arata
    • Journal Title

      Neuroscience Res. 50

      Pages: 355-359

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.2005

    • Author(s)
      Kuroda K, Horiguchi Y, Nakashima J, Kikuchi E, Kanao K, Miyajima A, Ohigashi T, Umezawa K, Murai M
    • Journal Title

      Clin. Cancer Res. 11(15)

      Pages: 5590-5594

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390469
  • [Journal Article] Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc12005

    • Author(s)
      H.Takatsuna, M.Asagiri, T.Kubota, K.Oka, T.Osada, C.Sugiyama, H.Saito, K.Aoki, K.Ohya, H.Takayanagi, K.Umezawa
    • Journal Title

      J.Bone Mineral Res. 20

      Pages: 653-661

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Synergistic antiviral effect of oxanosine and ddI against human immunodeficiency virus2005

    • Author(s)
      M.Nakamura, T.Ogawa, A.Yokono, S.Nakamori, T.Ohno, K.Umezawa
    • Journal Title

      Biomed.Pharmacother. 59

      Pages: 47-50

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.2005

    • Author(s)
      Kuroda K, Horiguchi Y, Nakashima J, Kikuchi E, Kanao K, Miyajima A, Ohigashi T, Umezawa K, Murai M.
    • Journal Title

      Clin. Cancer Res 11

      Pages: 5590-5594

    • Data Source
      KAKENHI-PROJECT-16390469
  • [Journal Article] Diabetes mellitus : rational basis, clinical approach and future therapy2004

    • Author(s)
      H.Ohgawara, K.Edamura, M.Kawakami, K.Umezawa
    • Journal Title

      Biomed.Pharmacother. 58

      Pages: 605-609

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Isolation of Heptadepsin, a Novel Bacterial Cyclic Depsipeptide that inhibits Lipopolysaccharide Activity2004

    • Author(s)
      O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, N.Kinoshita, Y.Suzuki, K.Miyake, K.Umezawa
    • Journal Title

      Chemistry & Biology 17-11

      Pages: 1059-1070

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15510187
  • [Journal Article] Screening of bioactive metabolites for pancreatic regeneration chemotherapy2004

    • Author(s)
      H.Takatsuna, K.Umezawa
    • Journal Title

      Biomed.Pharmacother. 58

      Pages: 610-613

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Genistein and daizein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs2004

    • Author(s)
      M.Murata, K.Midorikawa, M.Koh, K.Umezawa, S.Kawanishi
    • Journal Title

      Biochemistry 43

      Pages: 2569-2577

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, DHMEQ2004

    • Author(s)
      D.V.Starenki, H.Namba, V.A.Saenko, A.Ohtsuru, S.Maeda, K.Umezawa, S.Yamashita
    • Journal Title

      Clin.Cancer Res. 10

      Pages: 6821-6829

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Isolation of Heptadepsin, a Nobel Bacterial Cyclic Depsipeptide that inhibits Lipopolysaccharide Activity2004

    • Author(s)
      O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, N.Kinoshita, Y.Suzuki, K.Miyake, K.Umezawa
    • Journal Title

      Chemistry & Biology 17・11

      Pages: 1059-1070

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15510187
  • [Journal Article] Promotion of β cell differentiation by conophylline in fetal and neonatal rat pancreas2004

    • Author(s)
      T.Ogata, L.Li, S.Yamada, Y.Yamamoto, Y.Tanaka, I.Takei, K.Umezawa, I.Kojima
    • Journal Title

      Diabetes 53

      Pages: 2596-2602

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Isolation of Heptadepsin, a Nobel Bacterial Cyclic Depsipeptide that inhibits Lipopolysaccharide Activity2004

    • Author(s)
      O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, Y.Suzuki,...K.Umezawa
    • Journal Title

      Chemistry & Biology 11

      Pages: 1059-1070

    • Data Source
      KAKENHI-PROJECT-15510187
  • [Journal Article] Isolation of heptadepsin, a novel bacterial cyclic depsipeptide that inhibits lipopolysaccharide activity2004

    • Author(s)
      O.Ohno, Y.Ikeda, R.Sawa, M.Igarashi, N.Kinoshita, Y.Suzuki, K.Miyake, K.Umezawa
    • Journal Title

      Chemistry & Biology 11

      Pages: 1059-1070

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Induction of hisitidine decarboxylase in macrophages inhibited by the novel NF-kappa B inhibitor (-)-DHMEQ.

    • Author(s)
      E. Suzuki, K. Umezawa, et al
    • Journal Title

      Biochem. Biophys. Res. Commun. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Journal Article] Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-κB inhibitor

    • Author(s)
      H.Takatsuna, S.Morita, T.Nagatsu, M.Sawada, K.Umezawa
    • Journal Title

      Biomed.Pharmacother. (印刷中)

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] The novel NF-kB inhibitor, Dehydroxymethylepoxyquinomicin(DHMEQ)prevents local and remote organ injury following intestinal ischemia/reperfusion in rats.

    • Author(s)
      Tomomi Suzuki, Kenichiro Yamashita, Wataru Jomen, Shinya Ueki, Takeshi Aoyagi, Moto Fukai, Hiroyuki Furukawa, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo
    • Journal Title

      J Surg Res (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Journal Article] Reversal of drug resistance by COTC based on intracellular glutathione and glyoxalase

    • Author(s)
      D.Kamiya, Y.Uchihata, E.Ichikawa, K.Kato, K.Umezawa
    • Journal Title

      Biorg.Med.Chem.Lett. (印刷中)

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Inhibition of cellular adhesion in human umbilical vein endothelial cells by NF-κB inhibitor DHMEQ under flow

    • Author(s)
      O.Ohno, Y.Shima, Y.Ikeda, Y.Kawai, K.Sakurai, K.Watanabe, K.Umezawa
    • Journal Title

      Oncology Res. (印刷中)

    • Data Source
      KAKENHI-PROJECT-16073217
  • [Journal Article] Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor

    • Author(s)
      M. Sato, K. Nakanishi, S. Haga, M. Fujiyoshi, M. Baba, K. Mino, Yimin, H. Niwa, H. Yokoo, K. Umezawa, Y. Ohmiya, T. Kamiyama, S. Todo, A. Taketomi and M. Ozaki
    • Journal Title

      Oncology Res

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Journal Article] 新しいNF-κB阻害剤DHMEQの生物有機化学と抗炎症・抗がん剤への展望

    • Author(s)
      須貝威、梅澤一夫
    • Journal Title

      化学と生物 (印刷中)

    • Data Source
      KAKENHI-PROJECT-20611015
  • [Patent] 外用組成物の生産方法2018

    • Inventor(s)
      梅澤一夫、小出悠紀子
    • Industrial Property Rights Holder
      ブルネエズ株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2020
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Patent] マクロライド化合物の毒性のない抗炎症剤・抗転移剤としての新規用途2017

    • Inventor(s)
      梅澤一夫、林音知
    • Industrial Property Rights Holder
      愛知医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-193428
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Patent] Nrf2活性化剤2010

    • Inventor(s)
      梅澤一夫、袴田雅俊、後藤侑子
    • Industrial Property Rights Holder
      慶應義塾
    • Industrial Property Number
      2010-230930
    • Filing Date
      2010-10-13
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Patent] Nrf2活性化剤2010

    • Inventor(s)
      梅澤一夫、袴田雅俊、後藤優子
    • Industrial Property Rights Holder
      慶應義塾
    • Industrial Property Number
      2010-230930
    • Filing Date
      2010-10-13
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Patent] 医薬組成物2008

    • Inventor(s)
      梅澤一夫, ほか3名
    • Industrial Property Rights Holder
      慶應義塾
    • Industrial Property Number
      2008-166290
    • Filing Date
      2008-06-25
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Patent] 抗腫瘍剤に対する腫瘍細胞の感受性増強剤2006

    • Inventor(s)
      梅澤一夫他3名
    • Industrial Property Rights Holder
      慶應義塾
    • Industrial Property Number
      2006-274257
    • Filing Date
      2006-10-05
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Patent] NF-κBを阻害する抗炎症、抗癌剤2006

    • Inventor(s)
      梅澤一夫ほか
    • Industrial Property Rights Holder
      慶應義塾
    • Industrial Property Number
      2006-000902
    • Filing Date
      2006-01-05
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Presentation] クマササ含有成分および誘導体によるLPSに誘導される炎症反応の抑制2020

    • Author(s)
      林音知、深津仁見、小嶋しおり、梅澤一夫、小出直樹
    • Organizer
      第93回日本細菌学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] 新しいI-κB kinase β阻害剤ketomycinによる乳がん細胞の遊走・浸潤およびヒト臍帯静脈内皮細胞管腔形成の抑制。2019

    • Author(s)
      Lin Yinzhi、小嶋しおり、梅澤一夫
    • Organizer
      第23回がん分子標的治療学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] 深海カビAspergillusが産生するcyclopeninによる炎症誘起因子発現の抑制とハエ学習障害モデルの改善。2019

    • Author(s)
      林音知、王立岩、Wu Yanhua、小出直樹、梅澤一夫
    • Organizer
      新規素材探索研究会第18回セミナー
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫の細胞浸潤抑制と抗がん剤感受性の増強。2019

    • Author(s)
      Lin Yinzhi、小出直樹、梅澤一夫
    • Organizer
      第78回日本癌学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Role of peritoneal NF-κB on cancer and inflammation2019

    • Author(s)
      Kazuo Umezawa
    • Organizer
      Medical Forum in Shymkent, Kazakhstan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] 新しいI-κB kinase β阻害剤ketomycinによる細胞の遊走・浸潤および炎症性サイトカイン産生の抑制。2019

    • Author(s)
      Lin Yinzhi、杉浦信夫、小嶋しおり、小出直樹、梅澤一夫
    • Organizer
      第14回日本ケミカルバイオロジー学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] クマササ含有成分および誘導体によるLPS作用の阻害。2019

    • Author(s)
      Lin Yinzhi、深津仁見、小嶋しおり、梅澤一夫、小出直樹
    • Organizer
      第65回トキシンシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Amelioration of metabolic syndrome and neurodegenerative disease models by plant-derived alkaloid conophylline2018

    • Author(s)
      Kazuo Umezawa
    • Organizer
      21st International Symposium on Molecular Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] がん細胞の遊走を阻害する放線菌由来ketomycinのスクリーニングと乳がんMDA-MB-231細胞における2Dおよび3D浸潤の抑制2018

    • Author(s)
      Lin Yinzhi、梅澤一夫
    • Organizer
      第22回がん分子標的治療学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Inhibition of titanium dioxide nanoparticle-induced inflammatory reaction by NF-κB inhibitor DHMEQ in human macrophage-like cells2018

    • Author(s)
      Hitomi Fukatsu, Tamami Ukaji, Saeko Tada-Oikawa, Kiyora Izuoka, Yoshikazu Naiki, Takayuki Komatsu, Naoki Koide, Akihiko Ikegami, Sahoko Ichihara, Kazuo Umezawa
    • Organizer
      21st International Symposium on Molecular Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Discovery, mechanism of action, and therapeutic activity of NF-kappa B inhibitor DHMEQ2018

    • Author(s)
      Kazuo Umezawa
    • Organizer
      Conference “Future of Oncology is Laid Today”(招待講演)(国際学会)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] 放線菌由来細胞遊走阻害剤ketomycinの単離と乳がん細胞におけるMMP依存性浸潤の抑制2018

    • Author(s)
      Lin Yinzhi、Wu Yanhua、梅澤一夫
    • Organizer
      第13回日本ケミカルバイオロジー学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of 2D and 3D invasion of human breast carcinoma cells2018

    • Author(s)
      Yinzhi Lin, Yanhua Wu, Kazuo Umezawa
    • Organizer
      第77回日本癌学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] 新規NF-κB阻害剤SEMBLによる骨肉腫細胞および線維肉腫細胞に対する抗腫瘍効果2018

    • Author(s)
      松尾俊宏,梅澤一夫,松井卓哉,佐藤啓二,河南勝久,出家正隆
    • Organizer
      第91回日本整形外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] PM2.5モデルTiO2ナノ粒子に誘導されるマクロファージのIL-1 beta産生とNF-kappa B阻害剤DHMEQによる抑制2018

    • Author(s)
      深津仁見、梅澤一夫、森田奈央子、内記良一、小松孝行、小出直樹
    • Organizer
      新規素材探索研究会第17回セミナー
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫SP-2/0細胞のMMP-9およびMMP-13が関与する浸潤の抑制と抗がん剤感受性の増強2017

    • Author(s)
      Sidthipong Kulrawee、宇梶珠未、梅澤一夫
    • Organizer
      第21回がん分子標的治療学会2017.6.14-16
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Molecular design of sugar-free migracin analog migracinal that inhibits cancer cell migration and invasion2017

    • Author(s)
      Tamami Ukaji, Yinzhi Lin, Naoki Koide, and Kazuo Umezawa
    • Organizer
      第76回日本癌学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] NF-κB阻害剤DHMEQによるTiO2ナノ粒子に誘導されるマクロファージ炎症反応の抑制(若手奨励講演)2017

    • Author(s)
      宇梶珠未、深津仁見、及川佐枝子、出岡淑、市原佐保子、梅澤一夫、小出直樹
    • Organizer
      第64回トキシンシンポジウム
    • Place of Presentation
      有馬、兵庫
    • Year and Date
      2017-07-10
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of breast cancer cell migration and invasion2017

    • Author(s)
      Yinzhi Lin and Kazuo Umezawa
    • Organizer
      第76回日本癌学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] NF-κB阻害剤DHMEQによるナノ粒子誘導IL-1β産生の抑制2017

    • Author(s)
      深津仁見、宇梶珠、及川佐枝、出岡、市原佐保、小出直樹、梅澤一夫
    • Organizer
      第12回日本ケミカルバイオロジー学会 2017.6.7-9
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Inhibition of TiO2 nanoparticle-induced inflammatory reaction in macrophages by NF-κB inhibitor DHMEQ2017

    • Author(s)
      Kazuo Umezawa, Hitomi Fukatsu, Tamami Ukaji and Naoki Koide
    • Organizer
      13th Keio-Yonsei Joint Symposium(招待講演)(国際学会)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] NF-κB阻害剤DHMEQによるTiO2ナノ粒子に誘導されるマクロファージ炎症反応の抑制2017

    • Author(s)
      宇梶珠未、深津仁見、及川佐枝子、出岡淑、市原佐保子、梅澤一夫、小出直樹
    • Organizer
      第64回トキシンシンポジウム (若手奨励講演)
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] migracin脱糖アルデヒド体migracinalによる卵巣がん細胞遊走・浸潤の抑制2017

    • Author(s)
      宇梶珠未、林音知、梅澤一夫
    • Organizer
      第21回がん分子標的治療学会
    • Data Source
      KAKENHI-PROJECT-17K01967
  • [Presentation] Inhibition of MMP-mediated 3D breast cancer cell invasion by NF-κB inhibitor DHMEQ. (口演)2016

    • Author(s)
      Tamami Ukaji and Kazuo Umezawa
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜、神奈川
    • Year and Date
      2016-10-08
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 微生物由来migracin AによるIGF-1発現抑制を介した卵巣がん細胞遊走・浸潤の阻害2016

    • Author(s)
      宇梶珠未、Lin Yinzhi、梅澤一夫
    • Organizer
      第11回日本ケミカルバイオロジー学会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Inhibition of MMP-2-mediated cellular invasion by NF-κB inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis2016

    • Author(s)
      Tamami Ukaji and Kazuo Umezawa
    • Organizer
      12th Keio-Yonsei Joint Symposium 2016.10.21
    • Place of Presentation
      横浜、神奈川
    • Invited
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 微生物および植物由来LPS機能阻害物質の探索(若手奨励講演)2016

    • Author(s)
      Sidthipong Kulrawee、小出直樹、梅澤一夫
    • Organizer
      第63回トキシンシンポジウム
    • Place of Presentation
      天童、山形
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Inhibition of IGF-1-mediated cellular migration and invasion by migracin A in ovarian clear cell carcinoma cells.2016

    • Author(s)
      Tamami Ukaji and Kazuo Umezawa
    • Organizer
      AACR-JCA 10th Joint Conference in Hawaii
    • Place of Presentation
      Maui, USA.
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] NF-κB阻害剤DHMEQによる3Dがん細胞浸潤の抑制と機構解析2016

    • Author(s)
      宇梶珠未、Lin Yinzhi、梅澤一夫
    • Organizer
      第20回がん分子標的治療学会
    • Place of Presentation
      別府、大分
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 放線菌由来細胞遊走・浸潤阻害物質migracinの単離と作用機構2016

    • Author(s)
      Lin Yinzhi、宇梶珠未、梅澤一夫
    • Organizer
      第15回新規素材研究会
    • Place of Presentation
      新横浜、神奈川
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] NF-kappa B inhibitor, (-)-DHMEQ, as an anti-inflammatory agent in cosmetics.2015

    • Author(s)
      Kulrawee Sidthipong and Kazuo Umezawa
    • Organizer
      10th World Congress of the International Academy of Cosmetic Dermatology
    • Place of Presentation
      Rio de Janeiro, Brazil.
    • Year and Date
      2015-11-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Discovery and biological activity of epoxide-free DHMEQ analog: Compound of second generation.2015

    • Author(s)
      Kulrawee Sidthipong, Susumu Kobayashi, Kazuo Umezawa
    • Organizer
      BRICS Summit Satellite Symposium “Development of DHMEQ in BRICS countries”
    • Place of Presentation
      Ufa, Russia.
    • Year and Date
      2015-06-04
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 放線菌由来migracin Aによるvasohibin発現を介した卵巣がん細胞遊走の抑制。2015

    • Author(s)
      宇梶珠未、林音知、梅澤一夫
    • Organizer
      第19回がん分子標的治療学会
    • Place of Presentation
      松山
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 放線菌由来新規がん細胞遊走阻害物質migracinの発見と卵巣がん細胞における遊走・浸潤抑制の作用機構。2015

    • Author(s)
      宇梶珠未、Lin Yinzhi、梅澤一夫
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-09
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Inhibition of IGF-1 mediated cellular migration and invasion by migracin A in ovarian clear cell carcinoma cells.2015

    • Author(s)
      Tamami Ukaji and Kazuo Umezawa
    • Organizer
      European Gynecological Oncology Congress
    • Place of Presentation
      Nice, France.
    • Year and Date
      2015-10-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] LPS誘導性炎症反応を阻害する微生物生産物質の探索。2015

    • Author(s)
      梅澤一夫、小出直樹
    • Organizer
      第62回トキシンシンポジウム
    • Place of Presentation
      伊勢志摩
    • Year and Date
      2015-07-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 卵巣がん細胞におけるmigracin AによるIGF-1発現および遊走・浸潤の抑制。Inhibition of IGF-1 mediated cellular migration and invasion by migracin A in ovarian carcinoma cells.2015

    • Author(s)
      Tamami Ukaji and Kazuo Umezawa
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Discovery of DHMEQ and the role of peritoneal NF-kappa B on diseases.2015

    • Author(s)
      Kazuo Umezawa
    • Organizer
      BRICS Summit Satellite Symposium “Development of DHMEQ in BRICS countries”
    • Place of Presentation
      Ufa, Russia.
    • Year and Date
      2015-06-04
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Screening of signal transduction modulators that inhibit cancer cell growth and spread2014

    • Author(s)
      Kazuo Umezawa
    • Organizer
      DSK Mini-Symposium-Perspectives in Anticancer Drug Discovery and Development
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-11-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 新規alkylglutarimide化合物による成人T細胞白血病細胞のNF-kappa B阻害と選択的アポトーシス誘導2013

    • Author(s)
      宇梶 珠未、竹入 雅敏、伊藤 あゆみ、清水 史郎、 梅澤 一夫
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] NF-kappa B阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013

    • Author(s)
      野間 成人、清水 史郎、梅澤 一夫
    • Organizer
      日本がん分子標的治療学会 第16回学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Suppression of NO-induced beta cell death by (-)-DHMEQ via activation of Nrf2-ARE pathway and alteration of MAPK activity2013

    • Author(s)
      K. Umezawa, T. Ukaji, A. Ogasawara, S. Simizu and I. Takei
    • Organizer
      49th Annual European Association for the Study of Diabetes (EASD) Meeting 2013
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Neuroprotective effect of conophylline in cellular model of Parkinson’s disease2013

    • Author(s)
      Yukiko Sasazawa, Kazuo Umezawa, Siro Simizu
    • Organizer
      International Symposium on Mitochondria 2013
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] 新規(-)-DHMEQ誘導体の分子デザインとサイトカイン分泌の抑制2013

    • Author(s)
      Kulrawee Sidthipong、宇梶珠未、梅澤一夫
    • Organizer
      第17回がん分子標的治療学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Induction of NF-kappa B and induction of selective apoptosis by novel alkylglutarimide compounds in adult T-cell leukemia cells2013

    • Author(s)
      宇梶 珠未、竹入 雅敏、伊藤 あゆみ、清水 史郎、梅澤 一夫
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] 新規 epoxide-free (-)-DHMEQ 誘導体の分子デザインとサイトカイン分泌の抑制2013

    • Author(s)
      宇梶珠未、Kulrawee Sidthipong、小林進、梅澤一夫
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Conophyllineによるオートファジー誘導2013

    • Author(s)
      笹澤 有紀子、梅澤 一夫、清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会 第8回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] Anti-inflammatory and anticancer activities of novel NF-kappa B inhibitor DHMEQ2013

    • Author(s)
      Kazuo Umezawa
    • Organizer
      Eurasian Anticancer Conference
    • Place of Presentation
      Ufa, Russia
    • Invited
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Protection of β-cells from cell death by NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARF pathway2013

    • Author(s)
      K. Umezawa and I. Takei
    • Organizer
      The 18th World Congress on Advances in Oncology, and 16th International Symposium on Molecular Medicine
    • Place of Presentation
      Crete, Greece
    • Invited
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] conophyllineによる神経保護効果の解2013

    • Author(s)
      笹澤 有紀子、梅澤 一夫、清水 史郎
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] NF-κB阻害剤(-)-DHMEQはMMP-2依存性のマスト細胞浸潤を抑制する2013

    • Author(s)
      野間成人、清水史郎、梅澤一夫
    • Organizer
      第17回がん分子標的治療学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Molecular design of epoxide-free (-)-DHMEQ analog that inhibits NF-κB and cytokine secretions2013

    • Author(s)
      K. Sidthipong, S. Kobayashi and K. Umezawa
    • Organizer
      The 18th World Congress on Advances in Oncology, and 16th International Symposium on Molecular Medicine
    • Place of Presentation
      Crete, Greece
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Molecular design of novel NF-kappa B inhibitors active on inflammation and cancer2013

    • Author(s)
      Tamami Ukaji, Kulraweee Sidthipong, and Kazuo Umezawa
    • Organizer
      The 2nd Official Conference of the International Chemical Biology Society (ICBS2013)
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 炎症・癌を抑制するシグナル伝達阻害剤の探索と分子デザイン2012

    • Author(s)
      梅澤一夫
    • Organizer
      名古屋大学医学部グローバルCOE「第31回プログレスレポート会議」
    • Place of Presentation
      名古屋
    • Invited
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] DTCM-glutarimideによる成人T細胞白血病におけるRelBの分解とアポトーシス誘導2012

    • Author(s)
      伊藤あゆみ,清水史郎、梅澤一夫
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] NF-κB阻害剤の発見と臨床への橋渡し研究。文科省がん支援・化学療法基盤支援活動2012

    • Author(s)
      梅澤一夫
    • Organizer
      第2回シンポジウム「アカデミアからの抗がん剤創薬へ向けて」
    • Place of Presentation
      神奈川日吉(招待講演)
    • Year and Date
      2012-02-22
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 糖尿病に有用なシグナル伝達阻害剤の探索と分子デザイン2012

    • Author(s)
      梅澤一夫
    • Organizer
      第18回日本糖尿病眼科学会総会。第27回日本糖尿病合併症学会。
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Inhibition of canonical and noncanonical NF-κBs by (-)-DHMEQ2012

    • Author(s)
      K. Horie, K. Sidthipong, M. Takeiri, S. Simizu, and K. Umezawa
    • Organizer
      The 17th World Congress on Advances in Oncology, and 15th International Symposium on Molecular Medicine
    • Place of Presentation
      Crete, Greece
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Screening of cellular signaling inhibitors active on cancer and diabetes: Recent results2012

    • Author(s)
      Kazuo Umezawa
    • Organizer
      Forum of the Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University
    • Place of Presentation
      Thailand
    • Invited
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] (-)-DHMEQによるNF-kappa BのDNA結合および核局在の抑制2011

    • Author(s)
      堀江佳奈、梅澤一夫, ほか
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Induction of apoptosis in adult T-cell leukemia cells by a novel PDK-1 inhibitor DTCM-glutarimide2011

    • Author(s)
      Ayumi Ito, Kazuo Umezawa, et al
    • Organizer
      The 16^<th> World Congress on Advances in Oncology, and 14^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      2011-10-06
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 新規PDK1阻害剤DTCM-glutarimideによるマウス悪性黒色腫細胞の浸潤抑制およびアノイキス誘導。Inhibition of cellular invasion and induction of anoikis by a novel PDK1 inhibitor, DTCM-glutarimide, in mouse melanoma cells2011

    • Author(s)
      兼田亜弓、梅澤一夫, ほか
    • Organizer
      日本分子標的がん治療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-22
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 9-methylstreptimidone由来新規PDK-1阻害物質DTCM-glutarimideによるin vivo炎症反応の抑制2011

    • Author(s)
      伊藤あゆみ、梅澤一夫, ほか
    • Organizer
      天然有機化合物討論会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-27
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 新規作用機構による(-)-DHMEQのnoncanonical NF-κB阻害2011

    • Author(s)
      竹入雅敏、梅澤一夫, et al
    • Organizer
      日本化学会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-28
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Galectin-3 binding proteinの作用と発現におけるNF-κBの関与。Regulation of Galectin-3 binding protein expression by NF-kappa B2011

    • Author(s)
      野間成人、清水史郎、梅澤一夫
    • Organizer
      日本分子標的がん治療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-22
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Screening from nature and molecular design of signal transduction inhibitors active on inflammation and cancer2011

    • Author(s)
      Kazuo Umezawa
    • Organizer
      14^<th> Asian Chemical Congress
    • Place of Presentation
      Bangkok, Thailand(invited speaker)
    • Year and Date
      2011-09-05
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Screening of NO production inhibitors in macrophages from microorganisms2011

    • Author(s)
      Chino Matsui, Kazuo Umezawa, et al
    • Organizer
      14^<th> Asian Chemical Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2011-09-05
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Amelioration of atopic dermatitis model in mice by NF-κB inhibitor DHMEQ and its mechanism of action2011

    • Author(s)
      K.Horie, K.Umezawa, et al
    • Organizer
      BIT's 9^<th> Annual Congress of International Drug Discovery Science and Technology (IDDST)-2011
    • Place of Presentation
      Shenzhen, China
    • Year and Date
      2011-11-03
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] (-)-DHMEQによるnoncanonical NF-kappa Bの新規阻害機構2011

    • Author(s)
      竹入雅敏、清水史郎、梅澤一夫, ほか
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-05-23
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] カビ由来pyranopaxillineおよび類縁体によるマクロファージ活性の抑制2011

    • Author(s)
      松井知野、梅澤一夫, ほか
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-05-23
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 新規PDK1阻害剤DTCM-glutarimideによるマウスメラノーマ細胞のアノイキス誘導および浸潤抑制2011

    • Author(s)
      竹入雅敏、梅澤一夫, ほか
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Screening and molecular design of signal transduction inhibitors active on inflammation and cancer2011

    • Author(s)
      Kazuo Umezawa
    • Organizer
      BIT's 9^<th> Annual Congress of International Drug Discovery Science and Technology (IDDST)-2011
    • Place of Presentation
      Shenzhen, China(invited speaker)
    • Year and Date
      2011-11-03
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] Role of peritoneal NF-κB on inflammation and cancer progression ; Lessons from the inhibitor DHMEQ2011

    • Author(s)
      Kazuo Umezawa
    • Organizer
      The 16^<th> World Congress on Advances in Oncology, and 14^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      2011-10-06
    • Data Source
      KAKENHI-PROJECT-23310163
  • [Presentation] 成人T細胞白血病MT-1細胞における(-)-DHMEQによるnoncanonical NF-κB活性化の抑制2010

    • Author(s)
      竹入雅敏、梅澤一夫, et al
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-07
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] (-)-DHMEQによるnoncanonical NF-κB阻害の分子機構解析2010

    • Author(s)
      竹入雅敏、梅澤一夫
    • Organizer
      新規素材探索研究会
    • Place of Presentation
      新横浜
    • Year and Date
      2010-06-11
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 高悪性度膀胱癌細胞の増殖・生存における転写因子AP-1およびNF-κBの関与2010

    • Author(s)
      鈴木絵里子、梅澤一夫, et al
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      東京(口演)
    • Year and Date
      2010-07-07
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 再生医療に有用な生理活性物質の探索と分子デザイン2010

    • Author(s)
      梅澤一夫
    • Organizer
      第4回ハイテク・リサーチ・センター・シンポジウム
    • Place of Presentation
      日吉(招待講演)
    • Year and Date
      2010-11-06
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Discovery of novel AP-1 inhibitor DTCM-glutarimide and its anti-inflammatory and anti-metastatic activities. (Invited speaker)2010

    • Author(s)
      兼田亜弓, 橘みゆき, 梅澤一夫
    • Organizer
      29^<th> Congress of Egyptian Society of Nephrology & Transplantation
    • Place of Presentation
      Cairo, Egypt
    • Year and Date
      2010-03-03
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Structure-activity relationship of NF-κB inhibitor DHMEQ and preparation of soluble analog.2010

    • Author(s)
      Chika Shimada, Kazuo Umezawa, et al
    • Organizer
      The 15^<th> World Congress on Advances in Oncology, and 13^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Loutraki, Greece
    • Year and Date
      2010-10-07
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] NF-κB阻害物質DHMEQ活性core分子のデザインと生物活性2010

    • Author(s)
      嶋田知佳、鈴木絵里子、斉藤毅、石川裕一、西山繁、梅澤一夫
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-18
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] NF-κB阻害物質DHMEQ活性core分子のデザインと生物活性2010

    • Author(s)
      嶋田知佳、梅澤一夫, et al
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-18
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Screening of bioactive metabolites active on tissue and cancer stem cells. (Invited speaker)2010

    • Author(s)
      梅澤一夫
    • Organizer
      29^<th> Congress of Egyptian Society of Nephrology & Transplantation
    • Place of Presentation
      Cairo, Egypt
    • Year and Date
      2010-03-03
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 低分子シグナル伝達阻害剤の探索と病態解析・医薬開発への応用2010

    • Author(s)
      梅澤一夫
    • Organizer
      2010年病理学会カンファレンス
    • Place of Presentation
      岡山(招待講演)
    • Year and Date
      2010-08-06
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Apoptosis and its regulation by chemical ligands. (Invited speaker)2010

    • Author(s)
      梅澤一夫
    • Organizer
      OOTR the 6^<th> Annual Conference
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-02-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 阻害剤のケミカルバイオロジーから得られるNF-κBの疾患における役割2010

    • Author(s)
      梅澤一夫
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2010-05-18
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Anti-inflammatory and anticancer activities of novel NF-κB inhibitor DHMEQ and its unique distribution in the body.2010

    • Author(s)
      Kazuo Umezawa
    • Organizer
      The 15^<th> World Congress on Advances in Oncology, and 13^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Loutraki, Greece(Invited speaker)
    • Year and Date
      2010-10-07
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Anticancer activity of novel NF-κB inhibitor DHMEQ and its unique distribution in the body.2010

    • Author(s)
      Kazuo Umezawa
    • Organizer
      Second World Congress on Cancer 2010(WCC-2010)
    • Place of Presentation
      Kottayam, Kerala, India(Invited speaker)
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Inhibition of noncanonical NF-kappa B activation by (-)-DHMEQ in vitro and in adult T-cell leukemia cells.2010

    • Author(s)
      M.Takeiri, K.Umezawa, et al
    • Organizer
      AACR 101th Annual Meeting
    • Place of Presentation
      Washington DC.
    • Year and Date
      2010-04-17
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Protein chemistry of target molecules for NF-κB inhibitor DHMEQ.2010

    • Author(s)
      K.Umezawa
    • Organizer
      Keio LCC-Yonsei CBMH Joint Symposium 2010
    • Place of Presentation
      日光(Invited speaker)
    • Year and Date
      2010-10-22
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 成人T細胞白血病細胞における(-)-DHMEQによるnoncanonical NF-kappa Bの抑制2010

    • Author(s)
      竹入雅敏、梅澤一夫, et al
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] エイズリンパ腫の薬物療法の新展開。(招待講演)2009

    • Author(s)
      梅澤一夫
    • Organizer
      公開シンポジウム「エイズとエイズリンパ腫治療の最前線」
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Screening and mechanistic study of natural signal transduction inhibitors. (Invited speaker)2009

    • Author(s)
      梅澤一夫
    • Organizer
      he 12^<th> International Symposium on Traditional Medicine in Toyama 第12回国際伝統医薬シンポジウム-和漢薬の科学基盤形成-
    • Place of Presentation
      富山
    • Year and Date
      2009-11-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 植物由来コノフィリンによるマスト細胞のインテグリン発現と脱顆粒の抑制 Suppression of integrin expression and degranulation by conophylline in mast cells2009

    • Author(s)
      岩佐俊, 梅澤一夫
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-21
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 抗炎症・抗がん活性のある分子標的医薬の探索と応用。(招待講演)2009

    • Author(s)
      梅澤一夫
    • Organizer
      第3回ハイテク・リサーチ・センター・シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2009-07-14
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] (-)-DHMEQによるCXCL12/CXCR4経由の卵巣癌細胞浸潤の抑制。(口演)2009

    • Author(s)
      宮西那実, 梅澤一夫
    • Organizer
      第13回がん分子標的治療学会学術総会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-25
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] (-)-DHMEQによるCXCL12/CXCR4 経由の卵巣癌細胞浸潤の抑制2009

    • Author(s)
      宮西那実、梅澤一夫
    • Organizer
      (口演)第13回がん分子標的治療学会学術総会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-25
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Proteomic analysis of AIDS-related lymphoma expressing proteins that are lowered by NF-κB inhibitor(-)-DHMEQ(エイズ関連リンパ腫細胞におけるNF-κB阻害剤(-)-DHMEQに発現が抑制されるタンパク質のスクリーニング)(口演)2009

    • Author(s)
      Y.Kambayashi, K.Umezawa, et al
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Inhibition of CARD11/Bcl-10/Malt1 complex-mediated leukotriene production by a specific NF-kappa B inhibitor, (-)-DHMEQ, in basophils. (oral presentation)2009

    • Author(s)
      鈴木絵里子, 梅澤一夫, et al
    • Organizer
      2^<nd> European Congress of Immunology
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2009-09-13
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 新規AP-1阻害剤の探索、合成と作用機構2009

    • Author(s)
      橘みゆき, 石川裕一, 西山繁, 梅澤一夫
    • Organizer
      第4回日本ケミカルバイオロジー研究会(口演)
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-18
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] In vitro and in vivo anti-neoplastic activity of the specific NF-kappa B inhibitor DHMEQ on AIDS-related lymphoma. (Invited speaker)2009

    • Author(s)
      K.Umezawa, R.Horie, et al
    • Organizer
      The 14^<th> World Congress on Advances in On cology, and 12^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Loutraki, Greece
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] (-)-DHMEQによる noncanonical NF-kappaB 活性化経路の抑制と機構解析 Inhibition of noncanonical NF-kappaB activation by(-)-DHMEQ and the mechanistic study. (口演)2009

    • Author(s)
      竹入雅敏, 梅澤一夫
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-21
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 新規転写因子AP-1活性阻害剤DTCM-glutarimide の作用機構と生物活性2009

    • Author(s)
      兼田亜弓, 橘みゆき, 石川裕一, 西山繁, 梅澤一夫
    • Organizer
      第51回天然有機化合物討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-10-07
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Inhibition of CARMAI/Bcl-10/Maltl complex-mediated leukotriene production by a specific NF-kappa B inhibitor, (-)-DHMEQ, in mast cells.2009

    • Author(s)
      E. Suzuki, M. Takahata, M. Oya, K. Umezawa
    • Organizer
      Keystone Symposia, Allergy and Asthma
    • Place of Presentation
      Keystone, CO, USA
    • Year and Date
      2009-01-24
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Discovery of a novel AP-1 function inhibitor DTCM-glutarimide derived from an antibiotic 9-methylstreptimidone. (Invited speaker)2009

    • Author(s)
      橘みゆき, 梅澤一夫, et al
    • Organizer
      The 14^<th> World Congress on Advances in On cology, and 12^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Loutraki, Greece
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Screening of transcription factor inhibitors and application to Yin Yang 1 studies. (Invited speaker)2009

    • Author(s)
      梅澤一夫, 鈴木絵里子
    • Organizer
      First International Workshop on Prognostic and Therapeutic Roles of Yin Yang 1 in Cancer
    • Place of Presentation
      Catania, Italy
    • Year and Date
      2009-05-24
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Inhibtion of noncanonical NF-kappaB pathway by(-)-DHMEQ. ((-)-DHMEQによる noncanonical NF-kappa B活性化経路の抑制)2009

    • Author(s)
      M.Takeiri, A.Ogasawara, K.Umezawa
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 腎癌細胞表面のSLCトランスポーターOAT1による抗癌剤の取り込みと低酸素の影響。(口演)2009

    • Author(s)
      鈴木絵里子, 梅澤一夫, 大家基嗣
    • Organizer
      第13回がん分子標的治療学会学術総会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-25
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] In vitro and in vivo anti-neoplastic activity of the specific NF-κB inhibitor DHMEQ on human multiple myeloma2009

    • Author(s)
      鈴木絵里子, 梅澤一夫, et al
    • Organizer
      2^<nd> International Congress on Leukemia Lymphoma Myeloma
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2009-05-21
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Proteomic analysis of anticancer activity of the specific NF-kappa B inhibitor DHMEQ on AIDS-related lymphoma. (Invited speaker)2009

    • Author(s)
      梅澤一夫
    • Organizer
      Keio LCC-Yonsei CBMH Joint Symposium 2009
    • Place of Presentation
      Gyeongju(慶州)Korea
    • Year and Date
      2009-09-25
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 転写因子に対する分子標的医薬の探索と抗癌活性2009

    • Author(s)
      梅澤一夫
    • Organizer
      バイオEXPO特別講演
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Screening of anaplastic large cell lymphoma-selective apoptosis inducing agents from natural products. (未分化大細胞リンパ腫選択的アポトーシスを誘導する天然物のスクリーニング)2009

    • Author(s)
      T.Toda, R.Horie, K.Umezawa
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 転写因子に対する分子標的医薬の探索と抗癌活性。(特別講演)2009

    • Author(s)
      梅澤一夫
    • Organizer
      バイオEXPO「癌治療ターゲットとゲノム解析」
    • Place of Presentation
      東京台場
    • Year and Date
      2009-07-03
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 微生物由来癌細胞遊送阻害物質の探索と paxilline の同定2009

    • Author(s)
      松井知野, 大平裕一, 梅澤一夫
    • Organizer
      新規素材探索研究会
    • Place of Presentation
      新横浜
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 生理活性物質の探索とケミカルバイオロジー2009

    • Author(s)
      梅澤一夫
    • Organizer
      「生体調節のケミカルバイオロジー」シンポジウム(招待講演)
    • Place of Presentation
      前橋
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Inhibition of mast cell functions by conophylline, a plant-derived alkaloid.2009

    • Author(s)
      S. Iwasa, K. Umezawa
    • Organizer
      Keystone Symposia, Allergy and Asthma
    • Place of Presentation
      Keystone, CO, USA
    • Year and Date
      2009-01-23
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] (-)-DHMEQによる noncanonical NF-kappa B活性化経路の抑制。(口演)2009

    • Author(s)
      竹入雅敏, 梅澤一夫
    • Organizer
      第13回がん分子標的治療学会学術総会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-25
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 新規AP-1阻害剤の合成と作用機構2009

    • Author(s)
      橘みゆき, 石川裕一, 西山繁, 梅澤一夫
    • Organizer
      新規素材探索研究会
    • Place of Presentation
      新横浜
    • Year and Date
      2009-06-05
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] The role of OAT1 on chemosensitivity in renal cell carcinoma cells. (腎癌細胞における有機アニオントランスポーターOAT1の薬剤感受性への寄与)(口演)2009

    • Author(s)
      E.Suzuki, K.Umezawa, M.Oya
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Inhibition of CXCL12/CXCL4-mediated cellular invasion by an NF-kappa B inhibitor, (-)-DHMEQ, in ovarian carcinoma cells2009

    • Author(s)
      宮西那実, 梅澤一夫
    • Organizer
      AACR
    • Place of Presentation
      Denver, USA
    • Year and Date
      2009-04-18
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 乳癌細胞の浸潤におけるNF-кBとCXCR4の関与。2008

    • Author(s)
      鈴木由紀乃, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 肥満細胞からのロイコトリエン産生におけるCBM complexを介したNF-кB活性化の関与。2008

    • Author(s)
      鈴木絵里子, 梅澤一夫
    • Organizer
      第7回新規素材探索研究会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Covalent biding of(-)-DHMEQ, a potent anticancer agent, to canonical and noncanonical NF-kappa B components.2008

    • Author(s)
      M. Takeiri, R. Horie, K. Umezawa
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] (-)-DHMEQの標的分子との結合様式の解明。(口演)2008

    • Author(s)
      小澤郁子, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 癌や糖尿病に対する新しい化学療法の開発。2008

    • Author(s)
      梅澤一夫
    • Organizer
      バイオアカデミックフォーラム(講演)
    • Place of Presentation
      東京
    • Year and Date
      2008-07-03
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 卵巣癌細胞におけるNF-кBの役割と(-)-DHMEQによる抑制。2008

    • Author(s)
      宮西那美, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] non-canonical NF-кB構成因子と(-)-DHMEQの結合解明。2008

    • Author(s)
      竹入雅敏, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Management of malignancies by reduction of systemic immune reactions. (Invited speaker)2008

    • Author(s)
      E. Suzuki, K. Umezawa
    • Organizer
      The Vascular Endothelium, Basic and Clinical Aspects. Seventh International Congress
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 選択的NFkB阻害剤DHMEQのドナー投与によるマウス膵島肝内移植成績の改善効果2008

    • Author(s)
      高橋 徹、松本秀一朗、敦賀陽介、葛西弘規、細田充主、渡辺正明、古川博之、松下通明、藤堂 省、尾崎倫孝、梅澤一夫
    • Organizer
      第20回代用臓器・再生医学研究会
    • Place of Presentation
      札幌 北海道大学学術交流会館
    • Year and Date
      2008-02-02
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Presentation] NF-кB阻害剤のDHMEQのepoxyquinol構造を有するparasitenoneの生物活性。2008

    • Author(s)
      高杉亜里紗, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] エイズ関連リンパ腫細胞の表現型解析とNF-кB阻害剤(-)-DHMEQによる抑制。2008

    • Author(s)
      神林佑輔, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] "THE IMMUNOMODULATORY EFFECT OF DONOR SPECIFIC TRANSFUSION PLUS NF-kB BLOCKADE BY UTILIZING A NOVEL INHIBITOR, DHMEQ.2008

    • Author(s)
      Ryoichi Goto, Kenichiro Yamashita, Takeshi Aoyagi, Shinya Ueki, Rumi Igarashi, Motohiro Uno, Tetsu Oura, Masaaki Watanabe, Tomohiro Shibata, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
    • Organizer
      8th international conference
    • Place of Presentation
      Berlin, Germany Intercontinental Berlin hotel
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Presentation] Screening of endothelial cell function inhibitors from microorganisms.2008

    • Author(s)
      K. Umezawa, O. Ohno
    • Organizer
      The 13^<th> World Congress on Advances in Oncology, and 11^<th> International Symposium on Molecular Medicine (Invited speaker)
    • Place of Presentation
      Hersonissos, Greece
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Inhibition of cellular invasion by an NF-kappa B inhibitor, (-)-DHMEQ, in ovarian carcinoma cells. (Invited speaker)2008

    • Author(s)
      N. Miyanishi, K. Umezawa, et al
    • Organizer
      The 13^<th> World Congress on Advances in Oncology, and 11^<th> International Symposium on Molecular Medicine (Invited speaker)
    • Place of Presentation
      Hersonissos, Greece
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] NF-кB阻害剤(-)-DHMEQの標的分子の解明。2008

    • Author(s)
      山本瑞生, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 生理活性物質の探索とヒト細胞機能の制御。2008

    • Author(s)
      梅澤一夫
    • Organizer
      第26回日本ヒト細胞学会学術集会(特別講演)
    • Place of Presentation
      東京
    • Year and Date
      2008-08-31
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] NF-kappa B阻害剤(-)-DHMEQによる癌・骨破壊の抑制。2008

    • Author(s)
      梅澤一夫
    • Organizer
      第11回癌と骨病変研究会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] (-)-DHMEQによるhistamine産生とC/EBPβ阻害の機構。2008

    • Author(s)
      二宮陽子, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Screening of microbial secondary metabolites that inhibit endothelial cell growth. (Invited speaker)2008

    • Author(s)
      K. Umezawa, O. Ohno
    • Organizer
      The Vascular Endothelium, Basic and Clinical Aspects. Seventh International Congress
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Screening of bioactive metabolites that inhibit cancer growth and natural immune reactions.2008

    • Author(s)
      K. Umezawa
    • Organizer
      The First International Symposium of Nanjing "Basic and Clinical Interface in Targeted Cancer Therapy", (Invited speaker)
    • Place of Presentation
      Nanjing, China
    • Year and Date
      2008-09-05
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] Activation of macrophages by cytokines secreted from cancer cells.2008

    • Author(s)
      A. Takasugi, E. Suzuki, K. Umezawa
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] NF-кB阻害剤(-)-DHMEQによるマスト細胞の活性化抑制。2008

    • Author(s)
      鈴木絵里子, 梅澤一夫
    • Organizer
      第12回がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 抗炎症物質の探索と新しい医療への応用(Screening of anti-inflammatory agents and application to new therapy)。2008

    • Author(s)
      梅澤一夫
    • Organizer
      理研セミナー(招待講演)
    • Place of Presentation
      埼玉県和光市
    • Year and Date
      2008-05-28
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 生理活性物質の探索とヒト細胞機能の制御2008

    • Author(s)
      梅澤一夫
    • Organizer
      第26回日本ヒト細胞学会学術集会
    • Place of Presentation
      東京(特別講演)
    • Year and Date
      2008-08-30
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] NF-кB阻害剤(-)-DHMEQの標的分子の解明と結合体モデルの合成。2008

    • Author(s)
      小澤郁子, 梅澤一夫
    • Organizer
      第3回日本ケミカルバイオロジー研究会(口演)
    • Place of Presentation
      東京
    • Year and Date
      2008-05-19
    • Data Source
      KAKENHI-PROJECT-20611015
  • [Presentation] 新規NF-kB阻害剤"DHMEQ"の漫性拒絶反応抑制効果2007

    • Author(s)
      植木伸也、山下健一郎、青柳武史、鈴木友己、谷口雅彦、嶋村剛、梅澤一夫、古川博之、尾崎倫孝、藤堂 省
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Presentation] "EFFECT OF A NOVEL NF-kB INHIBITOR, DEHYDROXYMETHYLEPOXYQUINOMICIN IN COMBINATION WITH DONOR SPECIFIC TRANSFUSION IN MOUSE HEART TRANSPLANTATION.2007

    • Author(s)
      Ryoichi Goto, Kenichiro Yamashita, Takeshi Aoyagi, Motohiro Uno, Shinya Ueki, Tomoo Itoh, Masahiko Taniguchi, Tomomi Suzuki, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo
    • Organizer
      American Transplant Congress
    • Place of Presentation
      San Francisco, CA Moscone West Convention Cneter
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Presentation] NF-κB as a target of anticancer agents : Anticancer activity and molecular target of an NF-κB inhibitor, DHMEQ.(シンポジウム講演)2007

    • Author(s)
      K. Umezawa
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-16073217
  • [Presentation] Donor pretreatment with a novel NF-kB inhibitor, DHMEQ can a lleviate the graft damage in syngenic marginal islet transplantation.2007

    • Author(s)
      Tohru Takahashi, Suichiro Matsumoto, Yosuke Tsuruga, Hironori Kasai, Masaaki Watanabe, Michitaka Ozaki, Hiroyuki Furukawa, Michiaki Matsushita, Kazuo Umezawa and Satoru Todo
    • Organizer
      Cell Transplantation society 2007 Joint Conference
    • Place of Presentation
      Minneapolisハイアットリージェンシー
    • Data Source
      KAKENHI-PROJECT-18209041
  • [Presentation] Isolation of novel metabolite migracin from Streptomyces that inhibits migration and invasion of ovarian carcinoma cells

    • Author(s)
      Tamami Ukaji, Kazuo Umezawa
    • Organizer
      Regional International Gynecologic Cancer Society (IGCS) Meeting
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2014-05-16 – 2014-05-18
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Conophyllineの抗ハンチントン病作用

    • Author(s)
      佐藤 夏実、笹澤 有紀子、梅澤 一夫、清水 史郎
    • Organizer
      日本ケミカルバイオロジー学会 第9回年会
    • Place of Presentation
      大阪大学(大阪府・豊中市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24310167
  • [Presentation] 新規NF-κB阻害剤Exo-ene EQによる卵巣がん細胞の浸潤抑制

    • Author(s)
      Kulrawee Sidthipong、梅澤一夫
    • Organizer
      第18回日本がん分子標的治療学会2014.6.25-27
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 放線菌由来新規がん細胞遊走阻害物質migracinの単離と卵巣がん細胞浸潤の抑制

    • Author(s)
      宇梶珠未、梅澤一夫
    • Organizer
      第18回日本がん分子標的治療学会2014.6.25-27
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 新規epoxide-free (-)-DHMEQ誘導体の分子デザイン・合成と抗炎症活性

    • Author(s)
      Kulrawee Sidthipong、小林進、梅澤一夫
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知
    • Year and Date
      2014-10-15 – 2014-10-17
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 放線菌由来新規細胞遊走阻害物質migracinの単離と管腔形成およびがん細胞浸潤の抑制

    • Author(s)
      宇梶 珠未、梅澤 一夫
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 低分子シグナル伝達阻害剤の探索とマトリクス修飾への応用

    • Author(s)
      梅澤一夫
    • Organizer
      第46回日本結合組織学会学術大会 第61回日本マトリクス研究会大会 合同集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-06-05 – 2014-06-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Inhibition of cancer cell invasion by bioactive metabolites

    • Author(s)
      Kazuo Umezawa
    • Organizer
      The 19th World Congress on Advances in Oncology, and 17th International Symposium on Molecular Medicine
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2014-10-09 – 2014-10-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Isolation of novel cell migration inhibitor migracins from Streptomyces and inhibition of cellular invasion in ovarian carcinoma cells

    • Author(s)
      Tamami Ukaji, Kazuo Umezawa
    • Organizer
      13th International Congress on Targeted Anticancer Therapies
    • Place of Presentation
      Paris
    • Year and Date
      2015-03-02 – 2015-03-04
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] 微生物由来新規細胞遊走阻害物質migracinの単離と 卵巣がん細胞浸潤の抑制

    • Author(s)
      宇梶珠未、梅澤一夫
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-26350975
  • [Presentation] Suppression of cellular invasion by novel NF-kappa B inhibitor Exo-ene EQ in ovarian carcinoma cells.

    • Author(s)
      Kulrawee Sidthipong, Kazuo Umezawa
    • Organizer
      The 19th World Congress on Advances in Oncology, and 17th International Symposium on Molecular Medicine
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2014-10-09 – 2014-10-11
    • Data Source
      KAKENHI-PROJECT-26350975
  • 1.  IKEDA Yoko (60159639)
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  • 2.  OZAKI Michitaka (80256510)
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  • 3.  FURUKAWA Hiroyuki (70292026)
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  • 4.  斎藤 政樹 (60012762)
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  • 5.  OTSUKA Masami (40126008)
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  • 6.  TODO Satoru (60136463)
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  • 7.  KISHINO Satoshi (90373026)
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  • 8.  SUZUKI Hidenori (30158977)
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  • 9.  SUGAI Takeshi (60171120)
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  • 10.  SIMIZU Siro (30312268)
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  • 19.  貞広 荘太郎
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  • 21.  BANNO Kouji (70265875)
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  • 22.  ISHIKAWA Yuichi (40348826)
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  • 25.  YAMASHITA Kenichiro (00399940)
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  • 26.  KAMACHI Hirofumi (60374237)
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  • 27.  MATSUSHITA Michiaki (20250425)
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  • 28.  OKAMOTO Yoshinari (20194409)
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  • 29.  YAMASAKI Tetsuo (60182474)
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  • 30.  OKAWARA Tadashi (60040325)
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  • 31.  IMOTO Masaya (60213253)
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  • 32.  SAWA Ryuichi (50235454)
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  • 33.  MURAI Masaru (90101956)
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  • 34.  NAKASHIMA Jun (10167546)
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  • 35.  OHIGASHI Takashi (80185371)
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  • 36.  OYA Mototsugu (00213885)
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  • 37.  MIYAJIMA Akira (90245572)
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  • 38.  MASAO Hayashi (60110516)
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  • 39.  NISHIDA Teruo (80036475)
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  • 40.  NAGATA Kazuhiro (50127114)
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  • 41.  SENO Nobuko (40017182)
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  • 42.  SUZUKI Sakaru (50022504)
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  • 43.  高久 史麿 (40048955)
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  • 44.  大野 竜三 (70093002)
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  • 45.  本間 良夫 (70142114)
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  • 53.  鈴木 芳和 (00348822)
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  • 55.  池田 満里子 (00051368)
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  • 57.  工藤 奨 (70306926)
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  • 62.  大澤 匡範 (60361606)
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  • 63.  KURIHARA Toshihide
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  • 64.  OSADA Hideto
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  • 65.  OZAWA Yoko
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  • 66.  ENDO Motoyoshi
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  • 67.  HIRASAWA Manabu
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  • 68.  HORIE Ryouichi
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  • 69.  SASAZAWA Yukiko
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  • 70.  TANAKA Nobuyuki
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  • 72.  NAKAZAWA Yuka
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  • 73.  SAENKO Vladimir
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  • 74.  MATSUSE Michiko
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  • 75.  OIKAWA Saeko
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  • 76.  SAHOKO Ichihara
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  • 77.  宮島 哲
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  • 78.  小沢 洋子
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  • 79.  戸田 枝里子
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  • 80.  北野 雄希
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  • 81.  石本 崇胤
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  • 82.  今井 克憲
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  • 83.  中川 茂樹
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  • 84.  尾池 雄一
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  • 85.  慶野 博
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  • 86.  渡邉 真理子
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  • 87.  澤田 誠
    # of Collaborated Projects: 0 results
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  • 88.  小坂 威雄
    # of Collaborated Projects: 0 results
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  • 89.  中出 幸臣
    # of Collaborated Projects: 0 results
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  • 90.  川谷 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 91.  長田 裕之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 92.  藤田 順之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 93.  荻 朋男
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 94.  光武 範吏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 95.  塚元 和弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 96.  小松 孝行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 97.  市原 学
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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