Une Mizuho 宇根瑞穂

… Alternative Names

宇根瑞穂ウネミズホ

UNE Mizuho 宇根瑞穂

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Researcher Number	20144826
Other IDs
Affiliation (Current)	2026: 広島国際大学, 薬学部, 客員教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 広島国際大学, 薬学部, 客員教授 2022: 広島国際大学, 薬学部, 教授 2006 – 2007: 広島国際大学, 薬学部, 教授 2002: 広島大学, 大学院・医歯薬総合研究科, 助手 1998 – 2001: 広島大学, 医学部, 助手
Review Section/Research Field	Except Principal Investigator Basic Section 53010:Gastroenterology-related / Medical pharmacy / Biological Sciences
Keywords	Except Principal Investigator MRP2 / 侵入阻害剤 / 胆汁酸誘導体 / ウイルス侵入機構 / 感染制御 / 侵入阻害 / 侵入機構 / B型肝炎ウイルス / natural products / pharmacokinetics … More / P-glycoprotein / isoflavone / flavone / reversing agent for multidrug resistance / ABC transporter / リポソーム / BCRP / MRP / 多剤耐性 / リボソーム / DDS / 薬物動態解析 / 天然植物成分 / 薬物動態 / P-糖タンパク質 / イソフラボン / フラボン / 多剤耐性克服剤 / ABCトランスポーター / adrenoleukodystrophy / アシル-CoA輸送 / ペルオキシソーム病 / トランスポータ / ABC蛋白 / 極長鎖脂肪酸 / 脂肪酸β酸化 / 脂肪酸輸送 / 脂質代謝 / 昆虫細胞発現系 / オルガネラ局在化 / 脂肪酸代謝 / 副腎脳白質ジストロフィー / タンパク質発現系 / Pex19p / ペルオキシソーム / トランスポーター / ABCタンパク質 Less

Elucidation of the Hepatitis B Virus Entry Mechanism and Infection Control via Entry Inhibitors
- Principal Investigator
  
  ITO Kiyoaki
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Aichi Medical University
Development of reversing agent for multidrug resistance and new chemotherapy by utilizing genistein
- Principal Investigator
  
  MURAKAMI Teruo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hiroshima International University
ペルオキシソーム膜ABCタンパク質の構造・機能と遺伝病
- Principal Investigator
  
  今中常雄
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Toyama Medical and Pharmaceutical University

All 2025 2024 2023 2022 2008

All Journal Article Presentation Patent

[Journal Article] Molecular mechanisms of hepatitis B virus entry inhibition by a bile acid derivative INT-767 to the preS1 region.2025
- Author(s)
  Okumura A, Muraki Y, Arai J, Nishimura S, Inden N, Sakamoto K, Kitada T, Kimoto S, Kitano R, Inoue T, Yamashita Y, Iguchi Y, Ohashi H, Watashi K, Wakita T, Une M, Ito K.
- Journal Title
  
  Antiviral Res
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice2024
- Author(s)
  Iguchi Yusuke、Yamashita Yukiko、Gohda Keigo、Oda Keisuke、Fujimori Ko、Sera Yukihiro、Imanaka Tsuneo、Yamaguchi Masafumi、Une Mizuho、Teno Naoki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 8 Pages: 1429-1436
- DOI
  10.1248/bpb.b24-00311
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-08-13
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24323
[Journal Article] Detoxication treatment for carbamazepine and lithium overdose2008
- Author(s)
  Unei, H., et. al.
- Journal Title
  
  Yakugaku Zasshi 128
  
  Pages: 165-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590162
[Patent] B型肝炎ウイルスに対する抗ウイルス効果を有する胆汁酸誘導体2023
- Inventor(s)
  伊藤清顕、奥村彰規、米田政志、宇根瑞穂、井口裕介、山下ユキコ
- Industrial Property Rights Holder
  学校法人愛知医科大学、学校法人常翔学園
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K24323
[Patent] B型肝炎ウイルスに対する抗ウイルス効果を有する胆汁酸誘導体2022
- Inventor(s)
  伊藤清顕、奥村彰規、米田政志、宇根瑞穂、井口裕介、山下ユキコ
- Industrial Property Rights Holder
  学校法人愛知医科大学、学校法人常翔学園
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] 胆汁酸誘導体INT-767による抗HBV効果の分子メカニズムの解明2024
- Author(s)
  奥村彰規, 荒井潤, 池田和由, 山下ユキコ, 井口裕介, 横川真梨子, 梅澤一夫, 宇根瑞穂, 大澤匡範, 伊藤清顕
- Organizer
  第110回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] 胆汁アルコールとその誘導体による抗HBV作用の検討2024
- Author(s)
  奥村彰規, 村木由起子, 井口裕介, 荒井潤, 山下ユキコ, 西村さやか, 位田法子, 宇根瑞穂, 伊藤清顕
- Organizer
  第45回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] Development of novel anti-HBV drugs based on AI technology using bile acid derivatives to inhibit HBV and NTCP binding2024
- Author(s)
  Okumura A, Ikeda K, Arai J, Sakamoto K, Muraki Y, Nishimura S, Inden N, Yokogawa M, Yamashita Y, Iguchi Y, Ohashi H, Watashi K, Wakita T, Une M, Osawa M, Ito K
- Organizer
  2024 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] B型肝炎ウイルスに直接作用する胆汁酸誘導体による新規治療薬の開発2023
- Author(s)
  奥村彰規，山下ユキコ，井口裕介，池田和由，横川真梨子，大澤匡範，宇根瑞穂，伊藤清顕
- Organizer
  第44回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] AH-337 is a novel bile acid derivative designed to inhibit HBV entry2023
- Author(s)
  Okumura A, Yamashita Y, Iguchi Y, Yokogawa M, Ohashi H, Arai J, Umezawa K, Ikeda K, Osawa M, Watashi K, Wakita T, Une M, Ito K
- Organizer
  2023 International HBV Meeting
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] Bile acid derivative INT-767 interacts with the preS1 of HBsAg2022
- Author(s)
  Okumura A, Yokogawa M, Yamashita Y, Iguchi Y, Ohashi H, Une M, Umezawa K, Watashi K, Wakita T, Yoneda M, Osawa M, Ito K
- Organizer
  2022 International HBV Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24323
[Presentation] 胆汁酸誘導体によるB型肝炎ウイルス感染制御2022
- Author(s)
  奥村彰規，伊藤清顕，横川真梨子，山下ユキコ, 井口裕介, 池田和由，大澤匡範, 宇根瑞穂，米田政志
- Organizer
  第43回胆汁酸研究会
- Data Source
  KAKENHI-PROJECT-23K24323

1. MURAKAMI Teruo (20136055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. MORI Nobuhiro (70412351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TOMOHARU Yokooji (70389120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ITO Kiyoaki (50551420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 今中常雄 (50119559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 守田雅志 (20191033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岡村昭治 (60019122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 古谷博和 (60253415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大澤匡範 (60361606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 梅澤一夫 (70114402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Une Mizuho 宇根 瑞穂

宇根 瑞穂 ウネ ミズホ

UNE Mizuho 宇根 瑞穂

Research Projects

Research Products

Co-Researchers

Elucidation of the Hepatitis B Virus Entry Mechanism and Infection Control via Entry Inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of reversing agent for multidrug resistance and new chemotherapy by utilizing genistein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペルオキシソーム膜ABCタンパク質の構造・機能と遺伝病

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Molecular mechanisms of hepatitis B virus entry inhibition by a bile acid derivative INT-767 to the preS1 region.2025

Author(s)

Journal Title

Data Source

[Journal Article] FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Detoxication treatment for carbamazepine and lithium overdose2008

Author(s)

Journal Title

Data Source

[Patent] B型肝炎ウイルスに対する抗ウイルス効果を有する胆汁酸誘導体2023

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] B型肝炎ウイルスに対する抗ウイルス効果を有する胆汁酸誘導体2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 胆汁酸誘導体INT-767による抗HBV効果の分子メカニズムの解明2024

Author(s)

Organizer

Data Source

[Presentation] 胆汁アルコールとその誘導体による抗HBV作用の検討2024

Author(s)

Organizer

Data Source

[Presentation] Development of novel anti-HBV drugs based on AI technology using bile acid derivatives to inhibit HBV and NTCP binding2024

Author(s)

Organizer

Data Source

[Presentation] B型肝炎ウイルスに直接作用する胆汁酸誘導体による新規治療薬の開発2023

Author(s)

Organizer

Data Source

[Presentation] AH-337 is a novel bile acid derivative designed to inhibit HBV entry2023

Author(s)

Organizer

Data Source

[Presentation] Bile acid derivative INT-767 interacts with the preS1 of HBsAg2022

Author(s)

Organizer

Data Source

[Presentation] 胆汁酸誘導体によるB型肝炎ウイルス感染制御2022

Author(s)

Organizer

Data Source

Une Mizuho 宇根瑞穂

宇根瑞穂ウネミズホ

UNE Mizuho 宇根瑞穂