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Sugiura Seiryo  杉浦 清了

ORCIDConnect your ORCID iD *help
… Alternative Names

杉浦 清了  スギウラ セイリヨウ

SUGIURA Seiryo  杉浦 清了

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Researcher Number 10272551
Other IDs
External Links
Affiliation (Current) 2025: 株式会社UT-Heart研究所, 研究開発部, 取締役 社長
Affiliation (based on the past Project Information) *help 2022 – 2023: 株式会社UT-Heart研究所, 研究開発部, 取締役 社長
2010: 東京大学, 大学院・新領域創成科学研究科, 特任教授
2006 – 2010: 東京大学, 新領域創成科学研究科, 教授
2007 – 2009: The University of Tokyo, Graduate School of Frontier Sciences, Professor
2008: 東京大学, 大学院新領域創成科学研究科, 教授 … More
2006: 東京大学, 大学院医学系研究科, 教授
2006: 東京大学, 大学院新領域創成科学研究科, 教授
2006: Univ.of Tokyo, Graduate School of Frontier Sciences, Professor, 新領域創成科学研究学科, 教授
2005: 東京大学, 大学院・新領域創成科学研究学科, 教授
2002 – 2005: University of Tokyo, Graduate School of Frontier Sciences, Professor, 大学院・新領域創成科学研究科, 教授
2003: University of Tokyo, Graduate school of Frontier Science, Professor, 新領域創生科学研究科, 教授
2002: 東京大学, 新領域創成科学研究科, 教授
1999 – 2001: 東京大学, 医学部, 助手
1998 – 2001: Univ. of Tokyo, Internal Med. , Assist. Prof., 医学部・附属病院, 助手
1997: 東京大学, 医学部附属病院, 助手
1996: 東京大学, 医学部, 助手
1996: 東京大学, 医学部・付属病院, 助手
1996: 東京大学, 医学部・附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Biomedical engineering/Biological material science / Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine / General physiology / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Materials/Mechanics of materials / Metabolomics / Biomedical engineering/Biological material science
Keywords
Principal Investigator
心筋細胞 / in vitro motility assay / インビトロアッセイ / 拡張型心筋症 / arrhythmia / electrophysiological model / cardiomyocyte / mechano-electrical feedback / シミュレーション工学 / 生理学 … More / 循環器・高血圧 / 不整脈 / 電気生理モデル / 機械-電気帰還現象 / carbon fiber / contractile force / cardiac myocyte / カーボンファイバー / 収縮力 / myosin light chain / Actin / ミオシン軽鎖 / アクチン / optical tweezer / in vitro motiliy assay / molecular biology / myosin / インビトロ アッセイ / 光ピンセット / 分子生物学 / ミオシン / 細胞シミュレーション / 微小計測 / 微小操作 / 機械刺激 / インビトロ運動再構成系 / 収縮性 / 心筋ミオシン … More
Except Principal Investigator
in vitro motility assay / subfragment-2 / ミオシン / baculovirus / unitary force / unitary displacement / Subfragment-2 / In vitro motility assay / レーザートラップ / ATP / カーボンファイバー / 筋収縮 / 心筋ミオシン / Ca^<2+>過渡現象 / ミオシンアイソフォーム / 心臓 / 慢性心不全 / 一酸化窒素 / ミオシン軽鎖 / 心不全 / 遺伝子治療 / 心臓シミュレーション / テンソル心電図 / 早期再分極症候群 / Bio-material Modeling / Biomechanics / Finite Element Method / Mixture Theory / Coronary Circulation / 生体材料モデル / 生体材料モデル化 / 生体力学 / 有限要素法 / 混合体理論 / 冠循環 / laser trap / myosin / ATPase活性 / in vitro motility assy / Telokin / Actin-activated ATPase activity / Laser trap / Myosin light chain phosphorylation / Myosin light chain kinase / Cardiac myosin / 単離心筋細胞 / 細胞内カルシウム濃度 / ミオシン連鎖リン酸化 / ミオシン軽鎖アイソフォーム / テロキン / アクチン活性化ATPase活性 / ミオシン軽鎖リン酸化酵素 / ミオシン軽鎖リン酸化 / Laser optical trap / Muscle contraction / Myosin isoform / Ventricular myocyte / Heart / レーザーオプティカルとラップ / レーザーオプティカルトラップ法 / 心室筋細胞 / peak oxygen uptake / anaerobic threshold / neuro-humoral factor / atrial natriuretic peptide / brain natriuretic peptide / nitric oxide / cardiac diseases / cardiac rehabilitation / 嫌気性代謝閾値 / 心筋梗塞 / 最大酸素摂取量 / 嫌気性代謝闘値 / 神経体液性因子 / 脳性利尿ペプチド / 心房性利尿ペプチド / 心疾患 / 心臓リハビリテーション / myosin light chain / cardiac myosin / 心筋 / アデノウイルス / カルシウムイオン / 分子生物学 / インビトロ再構成系 / signal transduction / hypertrophy / exercise / カルシニューリン / 運動 / 情報伝達 / カベオリン / スポーツ心臓 / 心肥大 / Ca^<2+> transients / adaptation / myoshin isoform / single myocyte / heart / 過負荷 / 心室筋 / 適応現象 / 単一心筋細胞 / image analysis / myofilament / electron microscope / gas environmental chamber / bilmolecules / 画像解析 / 筋フィラメント / 電子顕微鏡 / ガス雰囲気試料室 / 生体高分子 / renal disease / diabetes mellitus / hyper lipidemia / hypertension / Exercise test / plasma NOx / Exhaled gas / Nitric Oxide / 慢性閉寒性肺疾患 / 腎疾患 / 糖尿病 / 高脂血症 / 高血圧症 / 運動負荷 / 血中一酸化窒素代謝産物 / 呼気ガス / 炎症細胞 / T細胞 / VEGF / 脂肪細胞 / 血管新生 / 生体内分子イメージング / 内臓肥満 / 肥満 / リモデリング / 脂肪組織 / CD8陽性T細胞 / 分子イメージング / メタボリック症候群 / 免疫 / 慢性炎症 / 共焦点顕微鏡 / 生体分子イメージング / メタボリックシンドローム / アクチン / アクチン・ミオシン架橋 / SPring-8 / 冠微小循環 / フィジオーム / Klotho 遺伝子 / BTEB2 / 虚血再灌流 / サイトカイン / 動脈硬化 / 転写因子 / 平滑筋細胞 / 単一心筋 / 細胞内カルシウム / 膜融合リポソーム / アデノウィルスベクター / 筋小胞体Ca^<2+>ATPase / 遺伝子導入 / ナトリウムポンプ遺伝子 / アイチン滑り速度 / ミオシン調節軽鎖遺伝子 / 心筋βミオシン重鎖遺伝子 / チロシンキナーゼ / アポトーシス / カリウムチャンネル遺伝子 / アクチン滑り速度 / 収縮蛋白遺伝子異常 / インビトロ運動再構築系 / HERG遺伝子 / Cl^-チャンネル遺伝子 / K^+チャンネル遺伝子 / サルコメア蛋白遺伝子異常 / ミトコンドリア心筋症 / QT延長症候群 / 肥大型心筋症 Less
  • Research Projects

    (24 results)
  • Research Products

    (62 results)
  • Co-Researchers

    (52 People)
  •  インシリコモデルとテンソル心電図解析による早期再分極症候群の不整脈リスク分析

    • Principal Investigator
      岩崎 雄樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Nippon Medical School
  •  Multi-scale simulation model of cardiomyocyte based on the micromechanical measurement of subcellular structurePrincipal Investigator

    • Principal Investigator
      SUGIURA Seiryo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      The University of Tokyo
  •  In vivo molecular imaging analysis of pathophysiology in metabolic syndrome

    • Principal Investigator
      YAMASHITA Hiroshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      The University of Tokyo
  •  力伝達障害としての拡張型心筋症の病態メカニズムの解明Principal Investigator

    • Principal Investigator
      杉浦 清了
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Aphysiomic approach to evaluate the role of mechano-electrical feedback in arrhythmiaPrincipal Investigator

    • Principal Investigator
      SUGIURA Seiryo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      The University of Tokyo
  •  Multiphasic Mixture Modeling and Simulation of Coronary Circulation

    • Principal Investigator
      CHEN Xian
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Materials/Mechanics of materials
    • Research Institution
      Kyushu University
  •  Promotion of cardiovascular physiome focusing on coronary microcirculation and myocardial crossbridge dynamics

    • Principal Investigator
      KAJIYA Fumihiko
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Kawasaki University of Medical Welfare
      Kawasaki College of Allied Health Professions
  •  Investigation on the functional significance of myosin subfragment-2

    • Principal Investigator
      YAMASHITA Hiroshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Investigation on the functional significance of myosin light chain kinase and myosin light chain phosphorylation

    • Principal Investigator
      YAMASHITA Hiroshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Development of myosin isoform function in single ventricular myocytesHeart

    • Principal Investigator
      SUGI Haruo
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Teikyo University
  •  Development of novel therapeutic options for treating heart failure targeting the myosin light chain

    • Principal Investigator
      YAMASHITA Hiroshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Effect of cardiac rehabilitation on endogenous nitric oxide production in cardiac patients

    • Principal Investigator
      MATSUMOTO Akihiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Development of a Gene Transfer and Functional Evaluation System for an Isolated Single Cardiac Myocyte as a model for the Gene TherapyPrincipal Investigator

    • Principal Investigator
      SUGIURA Seiryo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立

    • Principal Investigator
      永井 良三
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Molecular mechanism of adaptation in human ventricular myosin

    • Principal Investigator
      SUGI Haruo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      School of Medicine, Teikyo University
  •  Signal transduction of physiological cardiac hypertrophy

    • Principal Investigator
      YOKOYAMA Ikuo, 青柳 昭彦
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Electron Microscopic Recording of Dynamic Structural Changes in Living Biomolecule

    • Principal Investigator
      SUGI Haruo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      General physiology
    • Research Institution
      Teikyo University Medical School
  •  Analysis of functional significance of mutant actin identified in hereditary dilated cardiomyopathyPrincipal Investigator

    • Principal Investigator
      SUGIURA Seiryo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  心筋細胞への経皮経冠動脈的遺伝子導入

    • Principal Investigator
      青柳 昭彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Establishment of nitric oxide measurement in exhaled air and its clinical application.

    • Principal Investigator
      HIRATA Yasunobu, 百村 伸一
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  Study on recombinant myosin which has high force output with high efficiencyPrincipal Investigator

    • Principal Investigator
      SUGIURA Seiryo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  心筋細胞の文化異常と病態形式

    • Principal Investigator
      古賀 義則
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kurume University
  •  心筋ミオシン分子の構造改変による最適な強心効果の導入に関する研究Principal Investigator

    • Principal Investigator
      杉浦 清了
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  心筋細胞への経冠動脈的遺伝子導入:SRCa^<2+> ATPASE 遺伝子及び変異ミオシン遺伝子の導入・発現の検討

    • Principal Investigator
      青柳 昭彦
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

  • [Journal Article] Critical role of cardiac t-tubule system for the maintenance of contractile function revealed by a 3D integrated model of cardiomyocytes2012

    • Author(s)
      Hatano A, Okada J, Hisada T, Sugiura S
    • Journal Title

      J Biomech

      Volume: 45 Pages: 815-823

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Journal Article] 心筋細胞のエネルギー代謝におけるミトコンドリアと筋小胞体Ca^<2+>放出チャンネルの相対位置の重要性2011

    • Author(s)
      波田野明日可、岡田純一、鷲尾巧、久田俊明、杉浦清了
    • Journal Title

      生体医工学

      Volume: Vol.49, No.6 Pages: 829-835

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Journal Article] A 3-D simulation model of cardiomyocyte integrating excitation-contraction coupling and metabolism2011

    • Author(s)
      Hatano A, Okada J, Washio T, Hisada T, Sugiura S
    • Journal Title

      Biophys J

      Volume: 101 Pages: 2601-2610

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Journal Article] Structural heterogeneity in the ventricular wall plays a significant role in the initiation of stretch-induced arrhythmias in perfused rabbit right ventricular tissues and whole heart preparations Circ Res2010

    • Author(s)
      Seo K, Inagaki M, Nishimura S, Hidaka I, Sugimachi M, Hisada T, Sugiura S
    • Volume
      106
    • Pages
      176-184
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Journal Article] CD8^+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
    • Journal Title

      Nature Medicine 15:8

      Pages: 914-920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591052
  • [Journal Article] CD8^+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.
    • Journal Title

      Nature Medicine 15:8

      Pages: 914-920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591052
  • [Journal Article] Direct demonstration of the cross-bridge recobery stroke in muscle filaments in aqueous solution by using the hydration chamber2008

    • Author(s)
      Sugi H, Sugiura S, et al.
    • Journal Title

      Poc Natl Acad Sci USA 105

      Pages: 17396-17401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Journal Article] Responses of single ventricular myocytes to dynamic axial stretching2008

    • Author(s)
      Nishimura S, Sugiura S et al.
    • Journal Title

      Prog Biophys Mol Biol 97

      Pages: 282-297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Journal Article] Responses of single ventricular myocytes to dynamic stretching2008

    • Author(s)
      Nishimura S, Sugiura S, et al.
    • Journal Title

      Prog Biophys Mol Biol 97

      Pages: 282-297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S
    • Journal Title

      J Clin Invest. 118(2)

      Pages: 710-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] バ-チャルハ-ト (2)マルチスケ-ル・マルチフィジックス心臓シミュレ-タの概要2008

    • Author(s)
      杉浦清了
    • Journal Title

      Angiology Frontier 7

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] The looped heart does not save energy by maintaining the momentum of blood flowing in the ventricle2008

    • Author(s)
      Watanabe H, Sugiura S, Hisada T
    • Journal Title

      Am J Physiol 294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S
    • Journal Title

      J CIin Invest 118(2)

      Pages: 710-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] The looped heart does not save energy by maintaining the momentum of blood flowing in the ventricle2008

    • Author(s)
      Watanabe H, Sugiura S, Hisada T
    • Journal Title

      Am J Physiol Heart Circ Physiol. 294(5)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Responses of single-ventricular myocytes to dynamic axial stretching2008

    • Author(s)
      Nishimura S, Seo K, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Nagai R, Sugiura S
    • Journal Title

      Prog Biophys Mol Biol. 97(2-3)(Review)

      Pages: 282-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Virtual Heart (1) An overview of the multi-scale, multi-physics Heart simulator (in Japanese)2008

    • Author(s)
      Sugiura S, et. al.
    • Journal Title

      Angiology Frontier 7

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] バーチャルハート(2)マルチスケール・マルチフィジックス心臓シミュレータの概要2008

    • Author(s)
      杉浦 清了
    • Journal Title

      Angiology Frontier 7

      Pages: 1-5

    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] The looped heart does not save energy by maintaining the momentum of blool flowing in the ventricle2008

    • Author(s)
      Watanabe H, Sugiura S, Hisada T
    • Journal Title

      Am J Physiol 294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Journal Article] Direct demonstration of the cross-bridge recovery stroke in muscle thick filaments in aqueous solution by using the hydration chamber2008

    • Author(s)
      Sugi H, Sugiura S et al.
    • Journal Title

      Poc Natl Acad Sci USA 105

      Pages: 17396-17401

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Journal Article] Virtual Heart (1) An overview of the multi-scale, multi-physics Heart simulator (in Japanese)2007

    • Author(s)
      Sugiura S, et. al.
    • Journal Title

      Angiology Frontier 6

      Pages: 291-295

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] バ-チャルハ-ト (1)マルチスケ-ル・マルチフィジックス心臓シミュレ-タの概要2007

    • Author(s)
      杉浦清了
    • Journal Title

      Angiology Frontier 6

      Pages: 291-295

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] Adipose Tissue Remodeling and Malfunctioning in Obesity Revealed by in vivo Molecular Imaging2007

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Kadowaki T, Nagai R, Sugiura S
    • Journal Title

      Bioimages 15

      Pages: 9-15

    • NAID

      10025009153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] バーチャルハート(1)マルチスケール・マルチフィジックス心臓シミュレータの概要2007

    • Author(s)
      杉浦 清了
    • Journal Title

      Angiology Frontier 6

      Pages: 291-295

    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] Carbon fiber technique for the investigation of single cell mechanics in intact cardiac myocytes2006

    • Author(s)
      Sugiura S, et. al.
    • Journal Title

      Nature Protocols 3

      Pages: 1453-1457

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] Carbon fiber technique for the investigation of single-cell mechanics in intact cardiac myocytes.2006

    • Author(s)
      Sugiura S, Nishimura S, Yasuda S, Hosoya Y, Katoh K
    • Journal Title

      Nat Protoc. 1・3

      Pages: 1453-7

    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Carbon fiber technique for the investigation of single cell mechanics in intact cardiac myocytes2006

    • Author(s)
      Sugiura S
    • Journal Title

      Nature Protocols 3

      Pages: 1453-1457

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] Carbon fiber technique for the investigation of single-cell mechanics in intact cardiac myocytes2006

    • Author(s)
      Sugiura S, Nishimura S, Yasuda S, Hosoya Y, Katoh K
    • Journal Title

      Nat Protoc. 1(3)

      Pages: 1453-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Microtubules modulate the stiffness of cardiomyocytes against shear stress2006

    • Author(s)
      Nishimura S, Nagai S, Katoh M, Yamashita H, Saeki Y, Okada J, Hisada T, Nagai R, Sugiura S
    • Journal Title

      Circ Res. 98(1)

      Pages: 81-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent manners.2006

    • Author(s)
      Nishimura S, Kawai Y, Nakajima T, Hosoya Y, Fujita H, Katoh M, Yamashita H, Nagai R, Sugiura S
    • Journal Title

      Cardiovasc Res. 72・3

      Pages: 403-11

    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Carbon fiber technique for the investigation of single cell mechanics in intact cardiac myocytes2006

    • Author(s)
      Sugiura S, et al.
    • Journal Title

      Nature Protocols 3

      Pages: 1453-1457

    • Data Source
      KAKENHI-PROJECT-18300147
  • [Journal Article] Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes2006

    • Author(s)
      Nishimura S, Nagai S, Sata M, Katoh M, Yamashita H, Saeki Y, Nagai R, Sugiura S
    • Journal Title

      Mol Cell Biochem. 286(1-2)

      Pages: 59-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent manners2006

    • Author(s)
      Nishimura S, Kawai Y, Nakajima T, Hosoya Y, Fujita H, Katoh M, Yamashita H, Nagai R, Sugiura S
    • Journal Title

      Cardiovasc Res. 72(3)

      Pages: 403-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions2005

    • Author(s)
      Nishimura S, Yamashita H, Katoh M, Yamada KP, Sunagawa K, Saeki Y, Ohnuki Y, Nagai R, Sugiura S
    • Journal Title

      J Mol Cell Cardiol 39(2)

      Pages: 231-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17200033
  • [Journal Article] Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions.2004

    • Author(s)
      Nishimura S., Yasuda S., Katoh M., Yamada KP., Yamashita H., Saeki Y., Sunagawa K., Nagai R., Hisada T., Sugiura S.
    • Journal Title

      American Journal of Physiology -Heart & Circulatory Physiology. 287(1)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590721
  • [Journal Article] Measurement of force developed by a single cardiac myocyte using novel carbon fibers.2003

    • Author(s)
      Sugiura S., Yasuda S., Yamashita H., Kato K., Saeki Y., Kaneko H., Suda Y., Nagai R., Sugi H.
    • Journal Title

      Advances in Experimental Medicine & Biology. 538

      Pages: 381-387

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590721
  • [Journal Article] Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytes.2003

    • Author(s)
      Yasuda S., Sugiura S., Yamashita H., Nishimura S., Saeki Y., Momomura S., Katoh K., Nagai R., Sugi H.
    • Journal Title

      American Journal of Physiology -Heart & Circulatory Physiology. 285(2)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590721
  • [Journal Article] Measurement of force developed by a single cardiac myocyte using novel carbon fiber2003

    • Author(s)
      杉浦 清了
    • Journal Title

      Advances in Experimental Medicine & Biology 538

      Pages: 381-387

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590721
  • [Journal Article] Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.2003

    • Author(s)
      Yamashita H., Sugiura S., Fujita H., Yasuda S., Nagai R., Saeki Y., Sunagawa K., Sugi H.
    • Journal Title

      Cardiovascular Research. 60(3)

      Pages: 580-588

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590721
  • [Presentation] 心筋細胞内3次元構造を再現した電気生理・エネルギー代謝・力学マルチフィジックスシミュレーション2011

    • Author(s)
      波田野明日可、岡田純一、鷲尾巧、久田俊明、杉浦清了
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学
    • Year and Date
      2011-04-30
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Micromechanical measurement by laser optical tweezer revealed anisotropy in the stiffness of rat ventricular myocytes2010

    • Author(s)
      Masumoto S, Fukano H, Iwanami S, Yamashita H, Hisada T, Sugiura S
    • Organizer
      The 20^<th> World Congress ISHR
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-05-16
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Ut Heart, a Multi-scale, Multi-physics Simulator2010

    • Author(s)
      Seiryo Sugiura, Takumi Washio, Jun-ichi Okada, Hiroshi Watanabe, Toshiaki Hisada
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Effect of stretch on ventricular arrhythmia2010

    • Author(s)
      SeoK, Inagaki M, Hidaka I, Sugimachi M, Nishimura S, Okada J, Washio T, Watanabe H, Hisada T, Sugiura S
    • Organizer
      5th International Workshop Cardiac mechano-electrical coupling and arrhythmias
    • Place of Presentation
      Oxford England
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Juxtaposition of Mitochondria to the Ca2+ release site is crucial for the cardiac energy balance- A 3D simulation of cardiomyocyte2010

    • Author(s)
      Hatano A, Okada J, Washio T, Hisada T, Sugiura S
    • Organizer
      19^<th> International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Micromechanical measurement by laser optical tweezer revealed anisotropy in the stiffness of rat ventricular myocytes2009

    • Author(s)
      Masumoto S, Fukano H, Iwanami S, Yamashita H, Hisada T, Sugiura S
    • Organizer
      The 26^<th> Annual Meeting of International Society for Heart Research Japanese Section
    • Place of Presentation
      Sapporo
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Multi-scale approach for the understanding of cardiac function Arrhythmia and muscle contraction2009

    • Author(s)
      Seiryo Sugiura(invited)
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Multi-scale approach for the understanding of cardiac function Arrhythmia and muscle contraction(Irisawa Memorial Symposium)2009

    • Author(s)
      Sugiura S, Hatano A, Washio T, Okada J, Watanabe H, Hisada T
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-30
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Induction of Ca^<2+> spark by mechanical stress is dependent on the direction of applied stresss in the rat ventricular myocytes2009

    • Author(s)
      Fukano H, Masumoto S, Iwanami S, Yamashita H, Hisada T, Sugiura S
    • Organizer
      The 26^<th> Annual Meeting of International Society for Heart Research Japanese Section
    • Place of Presentation
      Sapporo
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Inhomogeneous structure of the ventricular wall is a substrate for fatal arrhythmias by modulating the global stretch to create heterogeneous cellular response2009

    • Author(s)
      K Seo, M Inagaki, S Sugiura
    • Organizer
      32nd Annual Meeting of the Japanese Working Group Cardiac Structure and Metabolism
    • Place of Presentation
      Osaka
    • Year and Date
      2009-07-04
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Multi-scale, multi-physics heart simulator as a tool to link bench and bedside.2008

    • Author(s)
      Sugiura S, et al.
    • Organizer
      Mendel Symposium II Genes and the Heart, from bench to bedside
    • Place of Presentation
      Chateau Liblice, Czech Republic
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Is the contractile kysfunction of detubrlated cardiomyocytes caused only by the asynchrony of Ca^<2+> regulation?2008

    • Author(s)
      Fukano H, Seo K, Nisimura S, Yamasita H, Sugiura S
    • Organizer
      The 25^th Annual Meeting of International heart Research Japanese Section
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-05
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Presentation] Structural heterogeneity of the ventricular wall bridges the stretch-induced excitation of cardiac mvocvtes to the arrhythmias2008

    • Author(s)
      Seo K, Inagagi. M, Sugiura S
    • Organizer
      第31回心筋代謝研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Is the contractile dysfunction of detubulated cardiomyocytes caused only by the asynchrony of Ca^<2+> regulation?2008

    • Author(s)
      Fukano H, Seo K, Nishimura S, Yamashita H, Sugiura S
    • Organizer
      The 25^<th> Annual Meeting of International Heart Research Japanese Section
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Contribution of structural heterogeneity to stretch-induced arrhythmias examined in ventricular tissue and isolated myocytes.2008

    • Author(s)
      Seo K, Sugiura S, et al.
    • Organizer
      The 25^<th> Annual Meeting of International Heart Research Japanese Section
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-05
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Presentation] Structural heterogeneity of the ventricular wall bridges the stretch-induced excitation of cardiac myocytes to the arrhythmias2008

    • Author(s)
      Seo K, Inagagi M, Sugiura S
    • Organizer
      第31回心筋代謝研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Presentation] Contribution of structural heterogeneity to stretch-induced arrhythmias examined in ventricular tissue and isolated myocytes.2008

    • Author(s)
      Seo K, Sugiura S et al.
    • Organizer
      The 25th Annual Meeting of International Heart Research Japanese Section
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Is the contractile dysfunction of detubulated cardiomyocytes caused only by the asynchrony of Ca2+ regulation?2008

    • Author(s)
      Fukano H, Seo K, Nishimura S, Y amashita H, Sugiura S
    • Organizer
      The 25th Annual Meeting of International Heart Research Japanese Section
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] 冠循環と心筋収縮の関係へのモデルによるアプローチ,A simulation studyon the effect of cardiac contraction on the coronary circulation2008

    • Author(s)
      杉浦清了、岡田純一、鷲尾巧、渡邊浩志、久田俊明
    • Organizer
      第47回日本生体医工学会大会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Contribution of structural heterogeneity to stretch-induced arrhythmias examined in ventricular tissue and isolated myocytes2008

    • Author(s)
      Seo K, Inagaki M, Nishimura S, Sugimachi M, Hisada T, Sugiura S
    • Organizer
      The 25^<th> Annual Meeting of International Heart Research Japanese Section
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-12-05
    • Data Source
      KAKENHI-PROJECT-20300152
  • [Presentation] Multi-scale, multi-physics heart simulator as a tool to link bench and bedside.2008

    • Author(s)
      Sugiura S, et al.
    • Organizer
      Mendel Symposiium II Genes and the Heart, from bench to bedside
    • Place of Presentation
      Chateau Liblice, Czech Republic
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Presentation] 冠循環と心筋収縮の関係へぼのモデルによるアプローチ A simulation study on the effect of cardiac contraction on the coronary circulation2008

    • Author(s)
      杉浦 清了、岡田 純一、鷲尾 巧、渡辺 浩志、 久田 俊明
    • Organizer
      第47回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Data Source
      KAKENHI-PROJECT-19659197
  • [Presentation] Finite Element Analysis on the Hemodynamics of Coronary Circulation Based on Porohyperelastic Theory2006

    • Author(s)
      Chen, Y., Chen, X., Watanabe, H., Washio, T., Sugiura, S., Hisada, T
    • Organizer
      The 55th National Congress of Theoretical and Applied Mechanics, Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18360054
  • [Presentation] Fluid-Structure Interaction Analysis of Left and Right Ventricles with Coronary Circulation Based on Porohyperelastic Theory2006

    • Author(s)
      Watanabe, H., Chen, Y., Chen, X., Washio, T., Sugiura, S., Hisada, T
    • Organizer
      JSME 18th Computational Mechanics Conference, Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18360054
  • 1.  YAMASHITA Hiroshi (50323572)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 10 results
  • 2.  AOYAGI Teruhiko (10251240)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  MOMOMURA Shin-ichi (10190985)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 4.  YOKOYAMA Ikuo (10302720)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  SATA Masataka (80345214)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  KATOU Masayoshi (40306345)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 7.  HISADA Toshiaki (40126149)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 17 results
  • 8.  WATANABE Hiroshi (10282500)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  HIRATA Yasunobu (70167609)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  SUGI Haruo (20082076)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  SHIRAKAWA Ibuki (80236190)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  KOBAYASHI Takakazu (00112756)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  YAGI Naoto (80133940)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  HIMENO Ryutaro (60342838)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  SUGA Hiroyuki (90014117)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  TSUJIOKA Katsuhiko (30163801)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  FUJITA Hideo (70327336)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  TAKENAKA Katsu (20188204)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  MATSUMOTO Akihiro (70323574)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  永井 良三 (60207975)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 21.  KAJIYA Fumihiko (70029114)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HIRAMATSU Osamu (50208849)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  TACHIBANA Hiroyuki (00241216)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MOCHIZUKI Seiichi (60259596)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KATAOKA Noriyuki (20250681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  GOTO Masami (50148699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  SHIMIZU Juichiro (80294403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  MOHRI Satoshi (00294413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  NAKAMURA Kazufumi (10335630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  OGASAWARA Yasuo (10152365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  NINOMIYA Yoshifumi (70126241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  KOBAYASHI Naoya (10325102)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  NISHIMURA Satoshi (80456136)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 34.  NAKAJIMA Toshiaki (50227790)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  CHEN Xian (70313012)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 36.  古賀 義則 (50080669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  古川 哲史 (80251552)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  松原 弘明 (10239072)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  堀 久枝 (80014190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  杉山 理 (30111850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  芹澤 剛 (90143429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  木村 彰方 (60161551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  世古 義規 (30240708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  高橋 利之 (40236302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  小室 一成 (30260483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  鈴木 季直 (10082174)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  茶圓 茂 (60142452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  岩崎 雄樹 (60398865)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  塚田 弥生 (20301567)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  塚田 信吾 (80454205)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  福島 球琳男
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  渡辺 浩志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results

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※ この処理は、研究者本人だけが実行できます。

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