IWAKI Daisuke 岩城大輔

Researcher Number	10315492
Affiliation (based on the past Project Information) *help	2007 – 2011: Fukushima Medical University, 医学部, 助教 2009: Fukushima Medical University, 医学部, 助教 2003 – 2006: 福島県立医科大学, 医学部, 助手 2000 – 2003: 札幌医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Functional biochemistry / Immunology Except Principal Investigator Respiratory organ internal medicine / Biological Sciences / General medical chemistry
Keywords	Principal Investigator レクチン / 補体 / 自然免疫 / セリンプロテアーゼ / ペプチドグリカン / CD14 / Toll様受容体 / 異物認識 Except Principal Investigator SP-D / SP-A … More / 自然免疫 / Toll-like receptor / Toll様受容体 / MASP / ペプチドグリカン / CD14 / コレクチン / pulmonary surfactant / 肺サーファクタント蛋白質 / 肺サーファクタント / レクチン経路 / 補体 / ザイモザン / zymosan / alveolar macrophage / mannose receptor / scavenger receptor A / ザイモサン / 肺胞マクロファージ / マンノース受容体 / スカベンジャー受容体 / Molecular Evolution / Ficolin / Lectin Pathway / Complement / MBL / レクチン / 分子進化 / フィコリン / lung adenocarcinoma / autoantibody / radiation pneumonitis / idiopathic interstitial pneumonia / alveolar type II cells / 生体防御 / 膠原病合併間質性肺炎 / 放射線肺臓炎 / SP-C / A549細胞 / 肺腺がん / 自己抗体 / 放射性肺臓炎 / 特発性間質性肺炎 / 肺胞II型細胞 / innate immunity / peptidoglycan / collectin / リポ多糖 / TNF-alpha / 凝固系 / 糖鎖 / 生体分子 / 感染症 / 第2経路 / 免疫学 / パターン認識受容体 / 生体防御レクチン Less

The lectin complement pathway is involved in activation of the alternative pathway
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukushima Medical University
Analysis of complement activation in MASP-deficient micePrincipal Investigator
- Principal Investigator
  
  IWAKI Daisuke
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Fukushima Medical University
Toll様受容体病原体認識機構におけるコレクチンの役割Principal Investigator
- Principal Investigator
  
  岩城大輔
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Fukushima Medical University
生体防御レクチンとCD14・Toll様受容体関与の自然免疫生体防御の分子機構
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Innate immune host defense mediated by pulmonary sutfactant proteins and Toll-like receptors, and its clinical application.
- Principal Investigator
  
  KUROKI Yoshto
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Roles of host defense lectin.s in innate immunity
- Principal Investigator
  
  FUJITA Teizo
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  UNIVERCTTY
Molecular mechanisms of innate immune host defense mediated by lung-surfactant proteins A and D
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University
Clinical application for pathophysiological analysis, diagnosis and treatment of lung diseases by genes and their products expressed in alveolar type II cells.
- Principal Investigator
  
  KUROKI Yoshio
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Sapporo Medical University

All 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Mouse ficolin B Has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway2012
- Author(s)
  Endo Y, Iwaki D, Ishida Y, Takahashi M, Matsushita M, Fujita T.
- Journal Title
  
  J Biomed Biotechnol
  
  Pages: 105891-105891
- Data Source
  KAKENHI-PROJECT-21390086
[Journal Article] The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway2011
- Author(s)
  Iwaki D, Kanno K, Takahashi M, Endo Y, Matsushita M, and Fujita T.
- Journal Title
  
  J Immunol
  
  Volume: 187 Pages: 3751-3758
- Data Source
  KAKENHI-PROJECT-21390086
[Journal Article] The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway2011
- Author(s)
  Iwaki D, Kanno K, Takahashi M, Endo Y, Matsushita M, Fujita T
- Journal Title
  
  J Immunol
  
  Volume: 187(7) Issue: 7 Pages: 3751-8
- DOI
  10.4049/jimmunol.1100280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390086
[Journal Article] Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury2011
- Author(s)
  Schwaeble W J, Lynch N J, Clark J E, Marber M, Samani N J, All Y M, Dudler T, Parent B, Lhotta K, Wallis R, Farrar C A, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford C E, and Stover C M.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Pages: 7523-7528
- Data Source
  KAKENHI-PROJECT-21390086
[Journal Article] Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor2010
- Author(s)
  M. Takahashi, Y. Ishida, D. Iwaki, K. Kanno, T. Suzuki, Y. Endo, Y. Homma, T. Fujita
- Journal Title
  
  D.J. Exp. Med. 207
  
  Pages: 29-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770113
[Journal Article] Essential role of mannose-binding lectin-associated serine protease-l in activation of the complement factor D2010
- Author(s)
  Takahashi M, Ishida Y, Iwaki D, Kan no K, Suzuki T, Endo Y, Homma Y, and Fujita T.
- Journal Title
  
  J Exp Med
  
  Volume: 207 Pages: 29-37
- Data Source
  KAKENHI-PROJECT-21390086
[Journal Article] Interactions of ficolin and mannose-binding lect in with fibrinogen/fibrin augment the lect in complement pathway2009
- Author(s)
  Endo Y, Nakazawa N, Iwaki D, Takahashi M, Matsushita M, and Fujita T.
- Journal Title
  
  Jr Innate Immun
  
  Volume: 2 Pages: 33-42
- Data Source
  KAKENHI-PROJECT-21390086
[Journal Article] Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway.2009
- Author(s)
  Y. Endo, N. Nakazawa, D. Iwaki, M. Takahashi, M. Matsushita, T. Fujita
- Journal Title
  
  J. Innate. Immun. 2
  
  Pages: 33-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770113
[Journal Article] Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma.2008
- Author(s)
  K. Inoue, X. Wang, J. Saito, Y. Tanino, T. Ishida, D. Iwaki, T. Fujita, S. Kimura, M. Munakata
- Journal Title
  
  Allergol. Int. 57
  
  Pages: 57-64
- NAID
  10021246095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770113
[Journal Article] Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway.2008
- Author(s)
  M. Takahashi, D. Iwaki, K. Kanno, Y. Ishida, J. Xiong, M. Matsushita, Y. Endo, S. Miura, N. Ishii, K. Sugamura, T. Fujita
- Journal Title
  
  J. Immunol. 180
  
  Pages: 6132-6138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770113
[Journal Article] 補体活性化のレクチン経路とプロテアーゼ2007
- Author(s)
  岩城大輔
- Journal Title
  
  臨床・免疫アレルギー科 48・6
  
  Pages: 711-718
- NAID
  40015794098
- Data Source
  KAKENHI-PROJECT-19770113
[Journal Article] 補体活性化のレクチン経路とプロテアーゼ2007
- Author(s)
  岩城大輔、藤田禎三
- Journal Title
  
  臨床免疫・アレルギー科 48巻
  
  Pages: 711-718
- NAID
  40015794098
- Data Source
  KAKENHI-PROJECT-19770113
[Journal Article] Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway.2006
- Author(s)
  Daisuke Iwaki
- Journal Title
  
  J.Immunol. 177・12
  
  Pages: 8626-8632
- Data Source
  KAKENHI-PROJECT-16790291
[Journal Article] Production and purification of recombinants of mouse MASP-2 and sMAP.2005
- Author(s)
  Iwaki, D.et al.
- Journal Title
  
  J Endotoxin Res. 11(1)
  
  Pages: 47-50
- Data Source
  KAKENHI-PROJECT-13143204
[Journal Article] The CD14 region spanning amino acids 57-64 is critical for interaction with the extracellular Toll-like receptor 2 domain2005
- Author(s)
  Daisuke Iwaki
- Journal Title
  
  Biochem.Biophys.Res.Commun. 328・1
  
  Pages: 173-176
- Data Source
  KAKENHI-PROJECT-16790291
[Journal Article] Production and purification of recombinants of mouse MASP-2 and sMAP.2005
- Author(s)
  Daisuke Iwaki
- Journal Title
  
  J.Endotoxin Res. 11・1
  
  Pages: 47-50
- Data Source
  KAKENHI-PROJECT-16790291
[Journal Article] Production and purification of recombinants of mouse MASP-2 and sMAP.2005
- Author(s)
  Iwaki, D. et al.
- Journal Title
  
  J. Endotoxin Res. 11
  
  Pages: 47-50
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13143204
[Presentation] MASP1遺伝子産物の多機能性について2011
- Author(s)
  高橋実、岩城大輔、遠藤雄一、藤田禎三
- Organizer
  第48回補体シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-21390086
[Presentation] Activation of mannose-binding lectin-associated serine protease 3.2008
- Author(s)
  D. Iwaki, K. Kanno, M. Takahashi, Y. Endo, M. Matsushita, T. Fujita
- Organizer
  XXII International Complement Workshop, Basel
- Place of Presentation
  Switzerland
- Year and Date
  2008-09-30
- Data Source
  KAKENHI-PROJECT-19770113
[Presentation] MASP-3の活性化と機能解析2008
- Author(s)
  岩城大輔、菅野和子、高橋実、遠藤雄一、松下操、藤田禎三
- Organizer
  第73回インターフェロン・サイトカイン学会第19回生体防御学会第45回補体シンポジウム3学会合同大会
- Place of Presentation
  北海道札幌市
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19770113
[Presentation] Activation of mannose-binding lectin-associated serine protease 32008
- Author(s)
  Daisuke Iwaki
- Organizer
  XXII International Complement Workshop
- Place of Presentation
  Basel, Switzerland
- Year and Date
  2008-09-30
- Data Source
  KAKENHI-PROJECT-19770113
[Presentation] Mannose-binding lectin-associated serine protease 3 (MASP-3)の機能解析2008
- Author(s)
  岩城大輔、菅野和子、高橋実、遠藤雄一、松下操、藤田禎三
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19770113
[Presentation] Mannose-binding lectin-associated serone protease 3(MASP-3)の機能解析2008
- Author(s)
  岩城大輔
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19770113
[Presentation] MASP欠損マウスにおけるStaphylococcus aureusに対する食作用の解析2007
- Author(s)
  岩城大輔、菅野和子、高橋実、遠藤雄一、松下操、藤田禎三
- Organizer
  第44回補体シンポジウム
- Place of Presentation
  神奈川県平塚市
- Year and Date
  2007-08-24
- Data Source
  KAKENHI-PROJECT-19770113

1. KUROKI Yoshio (70161784)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TAKAHASHI Toru (40347159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SANO Hitomi (80295344)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. FUJITA Teizo (20134223)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. MURAKAMI Seiji (40315487)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKAHASHI Hiroki (60231396)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SOHMA Hitoshi (70226702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ENDO Yuidii (20117427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKATA Munehiro (00266371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAAKMURA Takanori (70183887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. AZUMI Kaoru (90221720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高橋実 (00285024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 水落次男 (90133149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 松下操 (00165812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAGAE Hisato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IWAKI Daisuke 岩城 大輔

Research Projects

Research Products

Co-Researchers

The lectin complement pathway is involved in activation of the alternative pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of complement activation in MASP-deficient micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Toll様受容体病原体認識機構におけるコレクチンの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生体防御レクチンとCD14・Toll様受容体関与の自然免疫生体防御の分子機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innate immune host defense mediated by pulmonary sutfactant proteins and Toll-like receptors, and its clinical application.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of host defense lectin.s in innate immunity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of innate immune host defense mediated by lung-surfactant proteins A and D

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical application for pathophysiological analysis, diagnosis and treatment of lung diseases by genes and their products expressed in alveolar type II cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mouse ficolin B Has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway2012

Author(s)

Journal Title

Data Source

[Journal Article] The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway2011

Author(s)

Journal Title

Data Source

[Journal Article] The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury2011

Author(s)

Journal Title

Data Source

[Journal Article] Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor2010

Author(s)

Journal Title

Data Source

[Journal Article] Essential role of mannose-binding lectin-associated serine protease-l in activation of the complement factor D2010

Author(s)

Journal Title

Data Source

[Journal Article] Interactions of ficolin and mannose-binding lect in with fibrinogen/fibrin augment the lect in complement pathway2009

Author(s)

Journal Title

IWAKI Daisuke 岩城大輔