HARAGUCHI Seiki 原口清輝

Researcher Number	10324576
Other IDs
Affiliation (Current)	2025: 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 上級研究員
Affiliation (based on the past Project Information) *help	2021 – 2025: 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 上級研究員 2013 – 2014: 独立行政法人農業・食品産業技術総合研究機構, 畜産草地研究所家畜育種繁殖研究領域, 主任研究員 2011: 千葉県がんセンター(研究所), 研究員 2001 – 2004: 滋賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory animal science / Developmental biology Except Principal Investigator Basic Section 42030:Animal life science-related / Basic Section 42010:Animal production science-related / Biological Sciences / Experimental pathology / Pediatrics
Keywords	Principal Investigator ES細胞 / マウス / ブタ / ニワトリ / テラトーマ / 異種間キメラ / トランスジェニックマウス / siRNA / dsRNA / RNAi … More Except Principal Investigator … More ブタ / アポトーシス / ゲノム編集 / ガラス化保存 / Drs / ノックアウトマウス / 癌抑制遺伝子 / 細胞不死化 / 樹状細胞 / 日本脳炎ウイルス / 豚繁殖・呼吸障害症候群ウイルス / アフリカ豚熱ウイルス / 宿主-病原体相互作用 / アカカワイノシシマクロファージ / 未成熟卵子 / DNA修復 / 卵子 / DNA修復機能 / 胚盤胞発生 / CD46 / OCT4 / DNA二本鎖切断 / ブタ接合体 / ブタ卵子 / Knockout mouse / Apoptosis / Tumor suppressor gene / UNC5D / 分化 / 依存性受容体 / 神経芽腫 / drs遺伝子 / 足場非依存性増殖 / がん抑制遺伝子 Less

Development of in vitro models for analysis of livestock pathogens using a red river hog macrophage cell line
- Principal Investigator
  
  竹之内敬人
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  National Agriculture and Food Research Organization
ブタ樹状細胞のin vitro増幅・培養系の構築
- Principal Investigator
  
  鈴木俊一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  National Agriculture and Food Research Organization
Efficient production of genome edited pigs from cryopreserved immature oocytes
- Principal Investigator
  
  ソムファイタマス
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  National Agriculture and Food Research Organization
Study of DNA damage and repair mechanism in porcine embryos obtained from vitrified oocytes and zygotes, and its relevance to genome editing
- Principal Investigator
  
  Somfai Tamas
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  National Agriculture and Food Research Organization
Evaluation of stem cell multipotency by interspecific chimera productionPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI Seiki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  National Agriculture and Food Research Organization
Functional role of the dependence receptor UNC5D in regulation Of cell death in neuroblastoma
- Principal Investigator
  
  LI Yuanyuan
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Chiba Cancer Center (Research Institute)
Functional analyses of novel tumor suppressor genes by gene targeting
- Principal Investigator
  
  INOUE Hirokazu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shiga University of Medical Science
Drs遺伝子機能と足場非依存性増殖の分子機構
- Principal Investigator
  
  井上寛一
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
dsRNAトランスジェニックマウスにおけるRNAi効果の検討Principal Investigator
- Principal Investigator
  
  原口清輝
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Shiga University of Medical Science
Drs遺伝子機能と足場非依存性増殖の分子機構
- Principal Investigator
  
  INOUE Hirokazu
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science

All 2023 2022 2021 2009 2004 2003 Other

All Journal Article Presentation

[Journal Article] Electroporation‐mediated genome editing in vitrified/warmed porcine zygotes obtained in vitro2023
- Author(s)
  Haraguchi Seiki、Dang‐Nguyen Thanh Q.、Kikuchi Kazuhiro、Somfai Tam?s
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 91 Issue: 1
- DOI
  10.1002/mrd.23712
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05912
[Journal Article] Vitrification of porcine immature oocytes and zygotes results in different levels of DNA damage which reflects developmental competence to the blastocyst stage2023
- Author(s)
  Somfai Tam?s、Haraguchi Seiki、Dang-Nguyen Thanh Quang、Kaneko Hiroyuki、Kikuchi Kazuhiro
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 3 Pages: e0282959-e0282959
- DOI
  10.1371/journal.pone.0282959
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05912
[Journal Article] Specific gene silencing in the pre-implantation stage mouse embryo by an siRNA expression vector system.2004
- Author(s)
  Haraguchi, S et al.
- Journal Title
  
  Mol.Reprod.Dev. 68
  
  Pages: 17-24
- NAID
  10012348758
- Data Source
  KAKENHI-PROJECT-15590335
[Journal Article] Specific gene silencing in the pre-implantation stage mouse embryo by a siRNA expression vector system2004
- Author(s)
  Haraguchi, S.et al.
- Journal Title
  
  Mol.Reprod.Dev 68
  
  Pages: 17-24
- NAID
  10012348758
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590335
[Journal Article] Specific gene silencing in the pre-implantation stage mouse embryo by an siRNA expression vector system.2004
- Author(s)
  Haraguchi, S., Saga, Y, Naito, K., Inoue, H., Seto, A.
- Journal Title
  
  Mol.Reprod.Dev. 68
  
  Pages: 17-24
- NAID
  10012348758
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590335
[Journal Article] A novel apoptotic pathway induced by the drs tumor suppressor gene.2004
- Author(s)
  Tambe, Y., Isono, T..Haraguchi, S., Yoshioka-Yamashita, A, Yutsudo, M.,, Inoue.H.
- Journal Title
  
  Oncogene 23
  
  Pages: 2977-2987
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590335
[Journal Article] Conserved role of nanos proteins in germ cell development.2003
- Author(s)
  Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., Saga, Y.
- Journal Title
  
  Science 301
  
  Pages: 1239-1241
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590335
[Journal Article] nanos1 : a mouse nanos gene expressed in the central nervous system is dispensable for normal development.2003
- Author(s)
  Haraguchi, S., Tsuda, M., Kitajima, S., Sasaoka, Y, Nomura-Kitabayashid, A., Kurokawa, K., Saga, Y.
- Journal Title
  
  Mech.Dev. 120
  
  Pages: 721-731
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590335
[Journal Article] Nanos 1 : a mouse nanos gene expressed in the central nerves system is dispensable for normal development2003
- Author(s)
  Haraguchi, S.et al.
- Journal Title
  
  Mech.Dev. 120
  
  Pages: 721-731
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590335
[Presentation] Vitrification of porcine immature oocytes and zygotes results in different levels of DNA damage in subsequently developing embryos.2022
- Author(s)
  Somfai T, Haraguchi S, Dang-Nguyen T.Q., Kikuchi K.
- Organizer
  International Congress on Animal Reproduction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05912
[Presentation] Application of Assisted Reproductive Techniques for the Preservation of Indigenous Pigs.2022
- Author(s)
  Somfai T, Haraguchi H, Dang-Nguyen T, Kikuchi K.
- Organizer
  The 6th Fatty Pig International Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05912
[Presentation] Vitrification of porcine immature oocytes causes DNA double-strand breaks in subsequently developing embryos2021
- Author(s)
  ソムファイタマス, 原口清輝, Dang-Nguyen TQ, 金子浩之, 菊地和弘
- Organizer
  Cryopreservation Conference 2021 (Online)
- Data Source
  KAKENHI-PROJECT-21K05912
[Presentation] Functional Role of Dependence Receptor UNC5D in Regulating Programmed Cell Death and Survival in Neuroblastoma2009
- Author(s)
  Yuanyuan Li, Yuyan Zhu, Miki Ohira, Seiki Haraguchi, Yohko Nakamura, Kiyoshi Asada, Toshikazu Ushijima, Atsuko Nakagawa, Hirofumi Arakawa, Akira Nakagawara
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21591378
[Presentation] ニワトリ胚を用いたマウスES細胞の多能性評価
- Author(s)
  松原悠子、細江実佐、原口清輝
- Organizer
  日本畜産学会第119会大会
- Place of Presentation
  宇都宮大学峰キャンパス（宇都宮市）
- Year and Date
  2015-03-28 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25640056
[Presentation] 異種間キメラによる幹細胞の多能性評価
- Author(s)
  原口清輝、松原悠子、細江実佐
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ（京都府民総合交流プラザ）（京都市）
- Year and Date
  2015-05-28 – 2015-05-30
- Data Source
  KAKENHI-PROJECT-25640056

1. INOUE Hirokazu (30176440)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. Somfai Tamas (90547720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. LI Yuanyuan (00392259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAKAMURA Ohko (60260254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NAKAGAWARA Akira (50117181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. MATSUBARA Yuko (90391573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 菊地和弘 (20360456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 千本正一郎 (60372661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 竹之内敬人 (20292518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 舛甚賢太郎 (70425578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 平松香菜恵 (20969513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 池田里奈 (50991395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 鈴木俊一 (90391581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山下敦子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 吉岡敦子(山下)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARAGUCHI Seiki 原口 清輝

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Evaluation of stem cell multipotency by interspecific chimera productionPrincipal Investigator

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dsRNAトランスジェニックマウスにおけるRNAi効果の検討Principal Investigator

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[Journal Article] Electroporation‐mediated genome editing in vitrified/warmed porcine zygotes obtained in vitro2023

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[Journal Article] Vitrification of porcine immature oocytes and zygotes results in different levels of DNA damage which reflects developmental competence to the blastocyst stage2023

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DOI

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[Journal Article] Specific gene silencing in the pre-implantation stage mouse embryo by an siRNA expression vector system.2004

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[Journal Article] Specific gene silencing in the pre-implantation stage mouse embryo by a siRNA expression vector system2004

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NAID

Description

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[Journal Article] Specific gene silencing in the pre-implantation stage mouse embryo by an siRNA expression vector system.2004

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HARAGUCHI Seiki 原口清輝