OKIGAKI Mituhiko 沖垣光彦

Researcher Number	10333197
Affiliation (based on the past Project Information) *help	2012 – 2013: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2012: 京都府立医科大学, 医学研究科, 准教授 2010: 京都府立医科大学, 医学研究科, 准教授 2006 – 2009: 京都府立医科大学, 医学研究科, 助教 2008: 京都府立医科大学, 医学部, 助教 2004 – 2006: Kyoto Prefectural University School of Medicine, Department of Cardiovascular Medicine, Instructor, 医学研究科, 助手 2001 – 2003: 関西医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator General pharmacology / Circulatory organs internal medicine / Kidney internal medicine / Respiratory organ internal medicine / Experimental pathology
Keywords	Principal Investigator PYK2 / チロシンキナーゼ / VEGF / 血管新生 / IL-1beta / knockout mice / Tyrosine kinase / 細胞遊走 / ノックアウトマウス / アポトーシス … More / FGF受容体 / FGF / Endothelial Progenitor Cells / Angiogenesis / 血管芽細胞 / atherosclerosis / 疾患モデルマウス / ApoE / マクロファージ / サイトカイン / 動脈硬化 / チロシンキナーぜ / 血管生物学 / 活性酸素 / ストレス … More Except Principal Investigator チロシンキナーゼ / 循環器 / 活性酸素 / Cardiovascular system / Reactive oxygen species / Genetically modified mice / 循環器・高血圧 / 酵素 / 遺伝子 / 遺伝子組み換えマウス / 線維化 / 腹膜透析 / 肝臓 / 高血圧症 / 酸化ストレス / 腎臓 / 細胞老化 / 糖尿病 / 慢性腎臓病 / NADPH オキシダーゼ / 活性酸素種 / メタボリックシンドローム / アポトーシス / サイトカイン / 高酸素 / チロシンキナーぜ / PYK2 / ARDS / CSK / トランスジェニックマウス / Src / 壁細胞 / 内皮細胞 / 動脈形成 / 血管新生 / 線維芽細胞増殖因子 / 骨髄細胞 / 末梢血 / PA6 / 同種骨髄移植 / 骨髄内骨髄移植 / ラット / マウス / 造血 / 放射線照射 / ストローマ細胞 / CFU-S / 静脈内骨髄移植 / 骨髄内骨髄移植(IBM-BMT) Less

Development of a new NOX1-targeted strategy for the treatment of metabolic syndrome
- Principal Investigator
  
  Yabe Chihiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
ＣＡＰＤにおける腹膜保全：チロシンキナーゼＰＹＫ２制御による線維化抑制
- Principal Investigator
  
  森泰清
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Mechanical role of tyrosine kinase PYK2 in cardiovascular stress response and therapeutic regulation of the kinase activityPrincipal Investigator
- Principal Investigator
  
  OKIGAKI Mituhiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Novel therapeutic strategy of ARDS by the development of Tyrosine kinase PYK2
- Principal Investigator
  
  NAGATA Kazuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
活性型線維芽細胞増殖因子受容体過剰発現マウスを用いた血管形成の解析
- Principal Investigator
  
  辰巳哲也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Src型チロシンリン酸化酵素の心血管ストレスシグナル分子としての役割の解明
- Principal Investigator
  
  計良夏哉
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
The role of Ca(2+) sensitive tyrosine kinase PYK2 as a molecule to transmit cardiovascular stressesPrincipal Investigator
- Principal Investigator
  
  OKIGAKI Mitsuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University of Medicine
Vascular remodeling in Nox1/NADPH oxidase deficient mice
- Principal Investigator
  
  YABE Chihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
造血幹細胞とstromal cellの同時骨髄内移植による骨髄移植法の開発
- Principal Investigator
  
  足立靖
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Kansai Medical University
Novel Functional Role of inflammatory cytokines, IL- 1beta, IL-6, and TNFalpha in angiogenesis revealed by analysis of their knockout micePrincipal Investigator
- Principal Investigator
  
  OKIGAKI Mitsuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto Prefectural University School of Medicine
  Kansai Medical University
Reduction of Atherogenesis in the Knock-out Mice of Tyrosine Kinase PYK2 which plays Essential Role in Cell Migration and Cytokine InductionPrincipal Investigator
- Principal Investigator
  
  OKIGAKI Mitsuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kansai Medical University

All 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Endothelial FGF receptor signaling accelerates atherosclerosis2011
- Author(s)
  Che J, Okigaki M, Takahashi T, Katsume A, Adachi Y, Yamaguchi S, Matsunaga S, Takeda M, Matsui A, Kishita E, Ikeda K, Yamada H, Matsubara H
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 300 Pages: 154-61
- Data Source
  KAKENHI-PROJECT-20590884
[Journal Article] Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system2011
- Author(s)
  Katsume A, Okigaki M, Matsui A, Che J, Adachi Y, Kishita E, Yamaguchi S, Ikeda K, Ueyama T, Matoba S, Yamada H, Matsubara H
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 31 Pages: 1084-92
- Data Source
  KAKENHI-PROJECT-20590884
[Journal Article] Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+channel to maintain endothelial integrity2010
- Author(s)
  Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, Kimura T, Sonomura K, Adachi Y, Shibuya M, Shirayama T, Tanda S, Hatta T, Sasaki S, Mori Y, Matsubara H
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 107 Pages: 19308-13
- Data Source
  KAKENHI-PROJECT-20590884
[Presentation] Aldosterone promotes vascular inflammation mediated by trans-activation of Caveolin/Angiotensin-II-Receptor-Type-1/tyrosine kinase PYK2 pathway2011
- Author(s)
  Yamaguchi S, Matui A, Okigaki M, Fukai K, Matsubara H
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-20590884
[Presentation] Non-genomic action of Aldosterone in VSMC requires translocation of Mineralocorticoid Receptor to the Caveolae in the plasma-membrane and sub-sequent trans-activation of AngiotensinII Type1 Receptor and its downstream tyrosine kinase PYK2/ROS/MAPK pathway2010
- Author(s)
  Yamaguchi S, Matui A, Okigaki M, Matsubara H
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20590884
[Presentation] Ca2+/Redox-Sensitive Tyrosine Kinase PYK2 Promotes Atherogenesis Through OxLDL/ROS/p21-Dependent Premature Senescence in Endothelium2009
- Author(s)
  Katsume A, Okigaki M, Matsui A, Jisan C, Yamaguchi S, Yamada H, Matsubara H
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-20590884
[Presentation] Calcium/Redox Sensitive Tyrosine Kinase Pyk2 Aggravates Myocardial Ishemia by Promoting Inflammatory Reactions and Cell Apoptosis2008
- Author(s)
  Kishita E, Honsho S, Yamaguchi S, Katsume A, Matsui A, Matsunaga S, Okigaki M, Matsubara H
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-20590884
[Presentation] Redox Sensitive Tyrosine Kinase PYK2 induced Reactive Oxygen Species/p21 -mediated Premature Senescence in Endothelium after Short Term Hypercholesterolemia, which is Crucial Events for Subsequent Progression of Atherosclerosis2008
- Author(s)
  Katsume Asako, Mitsuhiko Okigaki, Hiroaki Matsubara
- Organizer
  AHA (American Heart Association)
- Place of Presentation
  New Orleans
- Year and Date
  2008-11-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590822
[Presentation] Redox Sensitive Tyrosine Kinase PYK2 induced Reactive Oxygen Species/p21-mediated Premature Senescence in Endothelium after Short Term Hypercholesterolemia, which is Crucial Events for Subsequent Progression of Atherosclerosis2008
- Author(s)
  勝目あさ子, 沖垣光彦, 松原弘明
- Organizer
  AHA(米国心臓病学会)
- Place of Presentation
  米国ニューオリンズ
- Year and Date
  2008-11-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590822

1. MATSUBARA Hiroaki (10239072)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
2. Yabe Chihiro (70150571)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. IWATA Kazumi (60305571)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAGATA Kazuhiro (60298429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUMOTO Misaki (80533926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 足立靖 (10268336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 辰巳哲也 (20254328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小原幸 (80275198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 計良夏哉 (50267829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 沢田尚久 (00315938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 張嘉 (50599222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 森泰清 (40268371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKIGAKI Mituhiko 沖垣 光彦

Research Projects

Research Products

Co-Researchers

Development of a new NOX1-targeted strategy for the treatment of metabolic syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ＣＡＰＤにおける腹膜保全：チロシンキナーゼＰＹＫ２制御による線維化抑制

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanical role of tyrosine kinase PYK2 in cardiovascular stress response and therapeutic regulation of the kinase activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel therapeutic strategy of ARDS by the development of Tyrosine kinase PYK2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

活性型線維芽細胞増殖因子受容体過剰発現マウスを用いた血管形成の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Src型チロシンリン酸化酵素の心血管ストレスシグナル分子としての役割の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Ca(2+) sensitive tyrosine kinase PYK2 as a molecule to transmit cardiovascular stressesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Vascular remodeling in Nox1/NADPH oxidase deficient mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

造血幹細胞とstromal cellの同時骨髄内移植による骨髄移植法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel Functional Role of inflammatory cytokines, IL- 1beta, IL-6, and TNFalpha in angiogenesis revealed by analysis of their knockout micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reduction of Atherogenesis in the Knock-out Mice of Tyrosine Kinase PYK2 which plays Essential Role in Cell Migration and Cytokine InductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Endothelial FGF receptor signaling accelerates atherosclerosis2011

Author(s)

Journal Title

Data Source

[Journal Article] Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system2011

Author(s)

Journal Title

Data Source

[Journal Article] Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+channel to maintain endothelial integrity2010

Author(s)

OKIGAKI Mituhiko 沖垣光彦