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Takeshima Tsuguhide  武島 嗣英

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TAKESHIMA Tsuguhide  武島 嗣英

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Researcher Number 10360950
Other IDs
Affiliation (Current) 2025: 国立研究開発法人量子科学技術研究開発機構, QST病院 重粒子線治療研究部, 研究統括
2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 重粒子線治療研究部, 主幹研究員
Affiliation (based on the past Project Information) *help 2021 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 重粒子線治療研究部, 主幹研究員
2019 – 2020: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 重粒子線治療研究部, 主幹研究員(定常)
2012: 北海道大学, 大学院・医学研究科, 助教
2009 – 2011: Hokkaido University, 大学院・医学研究科, 特任助教
Review Section/Research Field
Principal Investigator
Radiation science / Basic Section 52040:Radiological sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Basic Section 52040:Radiological sciences-related / Radiation science
Keywords
Principal Investigator
免疫治療 / 放射線治療 / がん特異的CTL / 免疫療法 / 癌特異的キラーT細胞 / 担癌マウス / 癌治療法開発 / 癌 / CD8+細胞 / 重粒子線治療 … More / X線治療 / がん特異的抗体 / 癌反応性CTL / 癌反応性抗体 / 放射線療法 / 樹状細胞療法 / がん反応性CTL / がん結合抗体 / 樹状細胞 / 所属リンパ節 / 癌特異キラーT細胞 / 光イメージング / 転移 / 癌免疫治療 / 放射線治療生物学 … More
Except Principal Investigator
放射線 / 放射線治療 / 同所移植 / 免疫チェックポイント阻害剤 / 免疫微小環境 / 膵管癌 / 骨肉腫 / アブスコパル効果 / 腫瘍免疫 / Abscopal 効果 / 免疫 / 免疫療法併用 / 放射線療法 / 免疫併用療法 / 重粒子線 / 遠隔腫瘍 / 併用療法 / 抗腫瘍免疫 / Abscopal効果 / 重粒子線がん治療 / HIF/alpha / 低酸素 / translation / trascription / HIF-1a / HIF / UTR / 放射線生物学 Less
  • Research Projects

    (7 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (9 People)
  •  X-ray and carbon ion therapy, how do they promote tumor-specific CD8+ cells?Principal Investigator

    • Principal Investigator
      武島 嗣英
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  同所移植モデルによる難治性腫瘍免疫応答を誘導する免疫療法と放射線の併用戦略の検討

    • Principal Investigator
      高橋 豊
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Osaka University
  •  Improvement of conventional adoptive cell therapy for cancer utilized tumor-specific immune responses induced by radiation therapyPrincipal Investigator

    • Principal Investigator
      Takeshima Tsuguhide
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  Quantitative evaluation of radiation-induced immunostimulating effect

    • Principal Investigator
      Shimokawa Takashi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  がん細胞は自身の生存をかけ放射線域を逃れるべく上皮間葉移行をなしうるか

    • Principal Investigator
      西岡 健
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  癌特異的キラーT細胞を軸にした新規放射線・免疫併用癌治療モデルの開発Principal Investigator

    • Principal Investigator
      武島 嗣英
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  Development of a new radiation therapy to improve tumor immunity using tumor-bearing mouse with in vivo imaging techniquePrincipal Investigator

    • Principal Investigator
      TAKESHIMA Tsuguhide
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University

All 2021 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Radiation-induced Cancer Cell Repop ulation : A possible mechanism impli ed by experiments using transplanta ble mouse-derived sarcoma cell line.2011

    • Author(s)
      Nishioka T, Yasuda M, Takeshima T, Haga H, Miyai Y, Shibata KI, Yamaza ki R, Shirato H, Teduka M, Date H.
    • Journal Title

      Cell Struct Funct. 31(1)

      Pages: 13-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Journal Article] Radiation-induced Cancer Cell Repopulation : A possible mechanismimplied by experiments using transplantable mouse-derived sarcoma cell line.2011

    • Author(s)
      Nishioka T, Yasuda M, Takeshima T, Haga H, Miyai Y, Shibata KI, Yamazaki R, Shirato H, Teduka M, Date H.
    • Journal Title

      Cell Struct Funct.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

    • Author(s)
      Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
    • Journal Title

      Cancer Res.

      Volume: 70(7) Pages: 2697-706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy2010

    • Author(s)
      Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
    • Journal Title

      Cancer Res 70

      Pages: 2697-706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Journal Article] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

    • Author(s)
      Takeshima T, Chamoto K, Wakita D, O hkuri T, Togashi Y, Shirato H, Kita mura H, Nishimura T.
    • Journal Title

      Cancer Res. 70(7)

      Pages: 2697-706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] 次世代の重粒子線治療開発とその臨床利用に向けた放射線生物学研究2021

    • Author(s)
      下川 卓志, 黒澤 ふき, 小池 幸子, 小久保 年章, 鵜澤 玲子, 武島 嗣英, 稲庭 拓, 長谷川 純崇, 白井 敏之, 山田 滋
    • Organizer
      放射線による制癌シンポジウム, 日本放射線腫瘍学会 生物部会
    • Data Source
      KAKENHI-PROJECT-19K08110
  • [Presentation] Functional analysis of tumor-infiltrating neutrophils induced by tumor irradiation2011

    • Author(s)
      武島嗣英、脇田大功、角田健太郎、白土博樹、佐藤崇之、北村秀光、西村孝司
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋、名古屋国際会議場
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-23791377
  • [Presentation] Therapeutic applicatons of tumor-specific T lymphocytes (CTL) induced by tumor irradiation2011

    • Author(s)
      Takeshima T, Chamoto K, Ohkuri T, Shirato H, Kitamura H, Nishimura T
    • Organizer
      14^<th> ICRR2010 (International Gongress of Radiation Research 2011
    • Place of Presentation
      Warsaw, The Palace of Science and Culture, Poland
    • Year and Date
      2011-08-29
    • Data Source
      KAKENHI-PROJECT-23791377
  • [Presentation] The role of tumor-infiltration neutrophils induced by tumor irradiation2011

    • Author(s)
      Takeshima T, Wakita D, Kitamura H, Nishimura T, Shirato H
    • Organizer
      The 9th Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      札幌、北大フラテ会館
    • Year and Date
      2011-09-30
    • Data Source
      KAKENHI-PROJECT-23791377
  • [Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

    • Author(s)
      Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

    • Author(s)
      Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸・神戸国際展示場
    • Year and Date
      2010-08-23
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] 放射線治療による腫瘍縮小には癌特異的免疫が関与する2010

    • Author(s)
      武島嗣英、茶本健司、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
    • Organizer
      第49回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      札幌・ホテルさっぽろ芸文館
    • Year and Date
      2010-07-09
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

    • Author(s)
      Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
    • Organizer
      RRS2010 (Radiation Research Society 2010)
    • Place of Presentation
      Hawaii
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL : its potentiation by combination with Th1 cell therapy.2010

    • Author(s)
      Takeshima T, Chamoto K, Wakita D, Ohkuri T, Togashi Y, Shirato H, Kitamura H, Nishimura T.
    • Organizer
      RRS2010 (Radiation Research Society 2010)
    • Place of Presentation
      Hawaii (USA), Grand Wailea Resort Hotel
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Application of radiation-induced tumor-specific CTL for tumor therapy2010

    • Author(s)
      武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-21
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Application of radiation-induced tumor-specific CTL to adoptive tumor immunotherapy2010

    • Author(s)
      武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] 放射線治療による腫瘍縮小には癌特異的免疫が関与する2010

    • Author(s)
      武島嗣英、茶本健司、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
    • Organizer
      第49回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-09
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Application of radiation-induced tumor-specific CTL to adoptive tumor immunotherapy2010

    • Author(s)
      武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪・大阪国際会議場
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Application of radiation-induced tumor-specific CTL for tumor therapy2010

    • Author(s)
      武島嗣英、脇田大功、大栗敬則、白土博樹、北村秀光、西村孝司
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都・京都テルサ
    • Year and Date
      2010-10-21
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Augmentation of the therapeutic efficacy of Th1 cell-adjuvant therapy enhanced the therapeutic efficacy of combination with radiation therapy2009

    • Author(s)
      武島嗣英、茶本健司、脇田大功、大栗敬幸、白土博樹、北村秀光、西村孝司
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] 放射線癌治療におけるTh1細胞治療との併用効果2009

    • Author(s)
      武島嗣英、茶本健司、北村秀光、西村孝司、白土博樹
    • Organizer
      日本医学放射線学会北日本地方会
    • Place of Presentation
      東北大学医学部艮陵会館(宮城県)
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] 放射線癌治療におけるTh1細胞治療との併用効果2009

    • Author(s)
      武島嗣英、茶本健司、北村秀光、西村孝司、白土博樹
    • Organizer
      日本医学放射線学会北日本地方会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Augmentation of the therapeutic efficacy of Th1 cell-adjuvant therapy enhanced the therapeutic efficacy of combination with radiation therap2009

    • Author(s)
      武島嗣英、茶本健司、脇田大功、大栗敬幸、白土博樹、北村秀光、西村孝司
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Synergistic efficacy of radiation therapy and Th1 cell adjuvant therapy in mice-transplanted tumor2009

    • Author(s)
      Takeshima T., Chamoto K., Kitamura H., Nishimura T., Shirato H
    • Organizer
      The 7^<th> Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-07
    • Data Source
      KAKENHI-PROJECT-21791164
  • [Presentation] Synergistic efficacy of radiation therapy and Th1 cell adjuvant therapy in mice-transplanted tumor2009

    • Author(s)
      武島嗣英, 茶本健司, 北村秀光, 西村孝司, 白土博樹
    • Organizer
      The 7^<th> Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      北海道大学学術交流会館(北海道)
    • Year and Date
      2009-10-07
    • Data Source
      KAKENHI-PROJECT-21791164
  • 1.  高橋 豊 (40353461)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  Shimokawa Takashi (20608137)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  西岡 健 (80271659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  芳賀 永 (00292045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  安田 元昭 (90239765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  中島 菜花子 (50402863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  西尾 禎治 (40415526)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  小泉 雅彦 (90186594)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  皆巳 和賢 (90634593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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