YAMAGUCHI YOSHIHIRO 山口佳宏

… Alternative Names

YAMAGUCHI Yoshihiro 山口佳宏

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Researcher Number	10363524
Other IDs
External Links
Affiliation (Current)	2025: 熊本大学, 大学院人文社会科学研究部(文), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 熊本大学, 環境安全センター, 准教授 2007 – 2019: Kumamoto University, Environmental Safety Center, Associate Professor 2014 – 2015: 熊本大学, 学内共同利用施設等, 准教授 2006: 熊本大学, 環境安全センター, 助教授 2004 – 2005: 熊本大学, 大学院・医学薬学研究部, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy / Basic Section 43060:System genome science-related / Biological Sciences Except Principal Investigator Drug development chemistry / Basic Section 58040:Forensics medicine-related / Physical pharmacy / Nanomaterials chemistry / Environmental pharmacy
Keywords	Principal Investigator 速度論的解析 / X線結晶構造解析 / β-ラクタム剤 / 薬剤耐性菌 / 酵素 / 加水分解酵素 / 阻害剤 / Zn酵素 / 熱力学的解析 / メタロ-β-ラクタマーゼ … More / DNA増幅 / メタゲノム / DNA断片の均一化 / 構造機能解析 / 蛋白質 / kinetics / x-ray crystallography / site-directed mutagenesis / inhibitor / substrate-recognition mechanism / β-lactam antibiotics / hydrolase / 部位特異的変異法 / 阻害剤開発 / 基質認識機構 / X線小角散乱 / 触媒機構 / 基質認識 / 亜鉛酵素 / 加水分解機構 / 高触媒活性 / メタロ－β－ラクタマーゼ / 溶液構造 / 結晶構造 / Zn(II)イオン / 国際情報交換 / タンパク質から分離 / 未知化合物 / 酵素阻害剤 / 蛋白質の発色 / インテグロン / 核酸認識 / 遺伝子組み換え酵素 / 多剤耐性菌 / 複核Zn酵素 / β-ラクタム剤加水分解酵素 / ペプチド阻害剤の探索 / ファージディスプレイ … More Except Principal Investigator 感染症 / DNA / ラクタマーゼ / 酵素 / 抗生物質 / 金属酵素 / 阻害剤 / β-ラクタム剤 / 非ベンゾジアゼピン系 / 薬物スクリーニング / 免疫学的検出法 / 組換え抗体 / 法医中毒学 / 向精神薬 / 抗体ファージライブラリー / 非ベンゾジアゼピン系睡眠薬 / 免疫学的検出 / 薬毒物スクリーニング / lactamase / inhibitor / infectious disease / β-lactam / 加水分解酵素 / β-ラタタム剤 / restriction enzyme / iron complex / optical active / 電子スペクトル / 錯体 / 制限酵素 / 鉄錯体 / 光学活性 / 抗菌機能 / ナノ材料 / 生体膜 / 液晶 / ナノシート / アゾベンゼン / 光応答性分子 / 光応答性材料 / β‐ラクタム剤 / 細菌感染症 / 細菌検査 / 蛍光検出 / βーラクタム剤 / 院内感染 / 細菌 / 耐性菌 / 薬学 / 薬剤耐性菌 / 医薬分子設計 Less

Improving DNA normalization methods for obtaining low-copy double-stranded DNA fragments from metagenomesPrincipal Investigator
- Principal Investigator
  
  山口佳宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Kumamoto University
非ベンゾジアゼピン系睡眠薬を標的とした抗体ファージライブラリーの構築と検出法開発
- Principal Investigator
  
  笹尾亜子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Kumamoto University
Physicochemical analysis of the effect of a single mutation on the active center and structure of metallo-beta-lactamasePrincipal Investigator
- Principal Investigator
  
  Yamaguchi Yoshihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of external-stimuli-responsive nanomaterials and evaluation of their compatibility with living cells
- Principal Investigator
  
  Kuwahara Yutaka
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nanomaterials chemistry
- Research Institution
  Kumamoto University
Physicochemical analysis of metallo-beta-lactamase with improved catalytic efficiency for cephem antibioticsPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Yoshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteria
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Kumamoto University
Physicochemical study and drug development for an unknown compound binding to metallo-beta-lactamasePrincipal Investigator
- Principal Investigator
  
  YOSHIHIRO Yamaguchi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of irreversible inhibitors forβ-lactam inactived enzyme, metallo-β-lactamase
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
細菌の多剤耐性化に関与するインテグラーゼの結晶構造と基質-酵素相互作用の解析Principal Investigator
- Principal Investigator
  
  山口佳宏
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ファージディスプレイ法によるメタロ-β-ラクタマーゼのペプチド阻害剤の網羅的探索Principal Investigator
- Principal Investigator
  
  山口佳宏
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Structure-based Design of Selective metallo-β-lactamase
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kumamoto University
Metallo-β-lactamase : Structural basis for substrate-specificity and rational design of the inhibitorsPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of functional molecules capable of recognizing and cleaving the bulge structure in DNA by using an optical active dinuclear iron complex
- Principal Investigator
  
  KUROSAKI Hiromasa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University

All 2019 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Comparison of Active-Site Loop Structures between IMP-1 and IMP-22015
- Author(s)
  Yamaguchi Y., Matsueda S., Matsunaga K., Takashio N., Toma-Fukai S., Yamagata Y., Shibata N., Wachino J., Shibayama K., Arakawa Y. & Kurosaki H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 1 Pages: 96-101
- DOI
  10.1248/bpb.b14-00594
- NAID
  130004872220
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131007, KAKENHI-PROJECT-26460037
[Journal Article] Crystallization and Preliminary X-ray Analysis of the Subclass B3 Metallo-β-Lactamase SMB-1 that Confers Carbapenem Resistance2012
- Author(s)
  J.Wachino, et al
- Journal Title
  
  Acta Cryst
  
  Volume: F68 Issue: 3 Pages: 343-346
- DOI
  10.1107/s1744309112004691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390008, KAKENHI-PROJECT-24790045
[Journal Article] Structural Insights into the Subclass B3 Metallo-β-Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo-β-Lactamase Inhibitor Mercaptoacetate2012
- Author(s)
  Jun-ichi Wachino, Yoshihiro Yamaguchi, Shigetarou Mori, Hiromasa Kurosaki, Yoshichika Arakawa, Keigo Shibayama
- Journal Title
  
  Antimicrob. Agents Chemother.
  
  Volume: 57 Issue: 1 Pages: 101-109
- DOI
  10.1128/aac.01264-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790045, KAKENHI-PROJECT-24790570
[Journal Article] A demetallation method for IMP-1 metallo-β-lactamase that restored enzymatic activity upon addition of metal ion(s)2011
- Author(s)
  Yoshihiro Yamaguchi, Shijia Ding, Emi Murakami, Kayo Imamura, Sachiko Fuchigami, Ryo Hashiguchi, Katsuhide Yutani, Hiromasa Mori, Shinnichiro Suzuki, Yoshichika Arakawa, Hiromasa Kurosaki
- Journal Title
  
  ChemBioChem
  
  Volume: 12(13) Pages: 1979-1983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] A demetallation method for IMP-1 metallo-ss-lactamase with restored enzymatic activity upon addition of metal ion(s)2011
- Author(s)
  Yamaguchi Y, Ding S, Murakami E, Imamura K, Fuchigami S, Hashiguchi R, Yutani K, Mori H, Suzuki S, Arakawa Y, Kurosaki H
- Journal Title
  
  ChemBioChem
  
  Volume: 12 Issue: 13 Pages: 1979-1983
- DOI
  10.1002/cbic.201100342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116, KAKENHI-PROJECT-22570166
[Journal Article] Metal preference of Zn(II) and Co(II) for the dinuclear metal binding site of IMP-1 metallo-β-lactamase and spectroscopic properties of Co(II)-substituted IMP-1 with mercaptoacetic acid2011
- Author(s)
  Yamaguchi Y, Imamura K, Sasao A, Murakami E, Arakawa Y, Kurosaki H
- Journal Title
  
  Med.Chem.Commun.
  
  Volume: 2 Issue: 8 Pages: 720-725
- DOI
  10.1039/c1md00062d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] Metal preference of Zn(II) and Co(II) for the dinuclear metal binding site of IMP-1 metallo-β-lactamase and spectroscopic properties of Co(II)-substituted IMP-1 with mercaptoacetic acid2011
- Author(s)
  Yoshihiro Yamaguchi, Kayo Imamura, Ako Sasao, Emi Murakami, Yoshichika Arakawa, Hiromasa Kurosaki
- Journal Title
  
  Med. Chem. Commun
  
  Volume: 2(8) Pages: 720-725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590116
[Journal Article] Crystallographic Investigation of the Inhibition Mode of a VIM-2 Metallo-β-lactamase from Pseudomonas aeruginosa by a Mercaptocarboxylate Inhibitor2007
- Author(s)
  Yamaguchi Y.
- Journal Title
  
  J.Med.Chem 50(26)
  
  Pages: 6647-6653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390038
[Journal Article] Crystallographic Investigation of the Inhibition Mode of a VIM-2 Metallo-β-lacta mase from Pseudomonas aeruginosa by a Mercaptocarboxylate Inhibitor2007
- Author(s)
  Yamaguchi Y.
- Journal Title
  
  J.Med.Chem. 50(26)
  
  Pages: 6647-6653
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390038
[Journal Article] Crystallographic investigation of the inhibition mode of a VIM-2 metallo-β-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor2007
- Author(s)
  Yamaguchi Y. (第一著者名)
- Journal Title
  
  Journal of Medicinal Chemistry 50(26)
  
  Pages: 6647-6653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790028
[Journal Article] Crystallographic Investigation of the Inhibition Mode of VIM-2 Metallo-β-lactamase from Pseudomonas aeruginosa by a Mercaptocarboxylate Inhibitor2007
- Author(s)
  Yoshihiro, Yamaguchi
- Journal Title
  
  Journal of Medicinal Chemistry 50 (26)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390038
[Journal Article] β-ラクタム剤耐性菌が産生するメタロ-β-ラクタマーゼの三次元構造に立脚した非可逆的阻害剤の開発2006
- Author(s)
  山口佳宏
- Journal Title
  
  The Japanese Journal of Antibiotics 59(1)
  
  Pages: 51-56
- NAID
  10017296202
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390017
[Journal Article] Structure-based drug design of the irreversible inhibitors of metallo-β-lactamases2006
- Author(s)
  Yoshihiro Yamaguchi
- Journal Title
  
  The Japanese Journal of Antibiotics 59(1)
  
  Pages: 51-56
- NAID
  10017296202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390017
[Journal Article] Probing the role of Asp120(81) of metallo-β-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography2005
- Author(s)
  Yoshihiro Yamaguchi
- Journal Title
  
  Journal of Biological Chemistry 280(21)
  
  Pages: 20824-20832
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390017
[Journal Article] Probing the role of Asp120(81) of metallo-β-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography2005
- Author(s)
  Yoshihiro Yamaguchi
- Journal Title
  
  Journal of Biological Chemistry (印刷中)
- Data Source
  KAKENHI-PROJECT-16390017
[Presentation] 亜鉛型βラクタム剤分解酵素のアミノ酸一変異による構造およびZn結合能への影響2019
- Author(s)
  俵紗季子, 松瀬奈月, 伊東理生, 藤間祥子, 山縣ゆり子, 和知野純一, 荒川宜親, 黒崎博雅, 山口佳宏
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K08240
[Presentation] 基質特異性向上の解明を目指したメタロ-β-ラクタマーゼKHM-1の結晶構造解析と速度論的解析2016
- Author(s)
  伊東理生、安田健二、西並　隆、古賀涼子、藤田美歌子、切替照雄、山縣ゆり子、黒崎博雅、山口佳宏
- Organizer
  第33回日本薬学会九州支部大会
- Place of Presentation
  鹿児島大学（郡元キャンパス）
- Data Source
  KAKENHI-PROJECT-26460037
[Presentation] Remote control of small particles modified with azobenzene derivatives by light irradiation2016
- Author(s)
  Yutaka Kuwahara, Yoshihiro Yamaguchi, Seiji Kurihara
- Organizer
  The Applied Nanotechnology and Nanoscience International Conference
- Place of Presentation
  Barcelina, Spain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26390020
[Presentation] 金属酵素メタロ-β-ラクタマーゼに結合した未知化合物の分離法の探索2015
- Author(s)
  山口佳宏、甲斐紀子、稲津　誠、荒川宜親、黒崎博雅
- Organizer
  日本蛋白質科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790045
[Presentation] 金属酵素メタロ-β-ラクタマーゼに結合した未知化合物の分離法の探索2014
- Author(s)
  山口佳宏、甲斐紀子、稲津誠、荒川宜親、黒崎博雅
- Organizer
  2014年度日本蛋白質科学会
- Place of Presentation
  横浜産貿ホールマリネリア
- Data Source
  KAKENHI-PROJECT-24790045
[Presentation] Development of fluorescent probes for metallo-β-lactamase-producing Gram-negative bacteria2013
- Author(s)
  Hiromasa Kurosaki, Yoshihiro Yamaguchi
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  Pacifico Yokohama, Yokohama
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteria2013
- Author(s)
  Hiromasa Kurosaki, Yoshihiro Yamaguchi
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  パシフィコ横浜(横浜市西区)
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] Citrobacter freundii由来メタロ-β-ラクタマーゼ（KHM-1）の単核Zn型および複核Zn型の結晶構造2012
- Author(s)
  山口佳宏、西並　隆、安田健二、切替照雄、山縣ゆり子、黒崎博雅
- Organizer
  第12回日本蛋白質科学会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-24790045
[Presentation] e-Learning in Environmental and Safety Education at Kumamoto University2012
- Author(s)
  Yoshihiro Yamaguchi
- Organizer
  SETAC Asia Pacific 2012
- Place of Presentation
  ANA Hotel Kumamoto New Sky, Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-24790045
[Presentation] メタロ-β-ラクタマーゼ活性阻害におけるメルカプトカルボン酸の至適炭素鎖長の決定と加水分解反応に及ぼすアニオンの影響2012
- Author(s)
  黒崎博雅、山口佳宏、荒川宜親
- Organizer
  第41回薬剤耐性菌研究会
- Place of Presentation
  岐阜県下呂市望川館コンベンションホール
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] 効率よくセフェム系βラクタム剤を加水分解するメタロ-β-ラクタマーゼ（KHM-1）の構造学的解2012
- Author(s)
  山口佳宏、西並　隆、安田健二、切替照雄、山縣ゆり子、黒崎博雅
- Organizer
  第10回次世代を担う若手のためのフィジカル・ファーマ・フォーラム
- Place of Presentation
  ホテル平安の森京都、京都
- Data Source
  KAKENHI-PROJECT-24790045
[Presentation] メタロ-β-ラクタマーゼ活性阻害におけるメルカプトカルボン酸の至敵炭素鎖長の決定と加水分解反応に及ぼすアニオンの影響2012
- Author(s)
  黒崎博雅、山口佳宏、荒川宜親
- Organizer
  第41回薬剤耐性菌研究会
- Place of Presentation
  望川館コンベンションホール, 岐阜県下呂市湯之島
- Data Source
  KAKENHI-PROJECT-24659054
[Presentation] etection of metallo-β-lactamase producing bacteria by fluorescent probe having dansyl and thiol groups2010
- Author(s)
  Koki MATSUDA, Yoshihiro YAMAGUCHI, Junzo HIROSE, Yoshichika ARAKAWA, Hiromasa KUROSAKI
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島文理大学(徳島)
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] Detection of metallo-β-lactamase producing bacteria by fluoresent probe having dansyl and thiol groups2010
- Author(s)
  Kouki Matsuda, Yoshihiro Yamaguchi, Junzo Hirose, Yoshichika Arakawa, Hiromasa Kurosaki
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島文理大学(徳島)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] 薬剤耐性菌が産生するメタロ-β-ラクタマーゼの蛍光検出法の開発:ダンシル基とチオール基をもつ蛍光剤のメタロ-β-ラクタマーゼIMP-1, VIM-2, IMD-7に対する蛍光特性と速度論的解析2009
- Author(s)
  松田幸喜, 山口佳宏, 廣瀬順造, 荒川宜親, 黒崎博雅
- Organizer
  第38回薬剤耐性菌研究会
- Place of Presentation
  森秋旅館(群馬県)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] 薬剤耐性菌が産生するメタロ-β-ラクタマーゼの蛍光検出法の開発:ダンシルとチオール基を持つ蛍光剤のメタロ-β-ラクタマーゼIMP-1, VIM-2, IND-7に対する蛍光特性と速度論解析2009
- Author(s)
  松田幸喜、山口佳宏、廣瀬順三、荒川宜親、黒崎博雅
- Organizer
  第38回薬剤耐性菌研究会
- Place of Presentation
  森秋旅館(群馬)
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-21590116
[Presentation] Purification of Integron Integrase (IntI1) that is responsible for mobility and integration of antibiotic resistance genes in Gram-negative bacteria2008
- Author(s)
  Yamaguchi Y.(第一著者)
- Organizer
  第8回あわじしま感染症・免疫フォーラム
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場
- Year and Date
  2008-09-09
- Data Source
  KAKENHI-PROJECT-19041061
[Presentation] Expression and purification of Integron Integrase (IntI1) that is responsible for multiple antibiotic resistance in bacteria2007
- Author(s)
  Yamaguchi Y. (第一著者)
- Organizer
  第7回あわじしま感染症・免疫フォーラム
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場
- Year and Date
  2007-09-03
- Data Source
  KAKENHI-PROJECT-19041061
[Presentation] 金属酵素メタロ-β-ラクタマーゼに結合した未知化合物の分離法の探索
- Author(s)
  山口佳宏、甲斐紀子、稲津　誠、荒川宜親、黒崎博雅
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26460037

1. KUROSAKI Hiromasa (70234599)

# of Collaborated Projects: 7 results

# of Collaborated Products: 14 results
2. ARAKAWA Yoshichika (10212622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. Kuwahara Yutaka (60347002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. WACHINO Jun-ichi (00535651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 栗原清二 (50225265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 後藤正文 (50080180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 笹尾亜子 (80284751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIRIKAE Teruo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. FUJITA Mikako

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. SHIMIZU Nobutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAGATA Yuriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

YAMAGUCHI YOSHIHIRO 山口 佳宏

YAMAGUCHI Yoshihiro 山口 佳宏

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Improving DNA normalization methods for obtaining low-copy double-stranded DNA fragments from metagenomesPrincipal Investigator

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非ベンゾジアゼピン系睡眠薬を標的とした抗体ファージライブラリーの構築と検出法開発

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Physicochemical analysis of the effect of a single mutation on the active center and structure of metallo-beta-lactamasePrincipal Investigator

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Development of external-stimuli-responsive nanomaterials and evaluation of their compatibility with living cells

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Physicochemical analysis of metallo-beta-lactamase with improved catalytic efficiency for cephem antibioticsPrincipal Investigator

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Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteria

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Physicochemical study and drug development for an unknown compound binding to metallo-beta-lactamasePrincipal Investigator

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Development of irreversible inhibitors forβ-lactam inactived enzyme, metallo-β-lactamase

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細菌の多剤耐性化に関与するインテグラーゼの結晶構造と基質-酵素相互作用の解析Principal Investigator

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ファージディスプレイ法によるメタロ-β-ラクタマーゼのペプチド阻害剤の網羅的探索Principal Investigator

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Structure-based Design of Selective metallo-β-lactamase

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Metallo-β-lactamase : Structural basis for substrate-specificity and rational design of the inhibitorsPrincipal Investigator

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Development of functional molecules capable of recognizing and cleaving the bulge structure in DNA by using an optical active dinuclear iron complex

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YAMAGUCHI YOSHIHIRO 山口佳宏

YAMAGUCHI Yoshihiro 山口佳宏