Sakoe Kumi 迫江公己

… Alternative Names

SAKOE Kumi 迫江公己

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Researcher Number	10398505
Affiliation (Current)	2025: 地方独立行政法人埼玉県立病院機構埼玉県立がんセンター(臨床腫瘍研究所), 病院遺伝科, がん研究職
Affiliation (based on the past Project Information) *help	2010 – 2011: 自治医科大学, 医学部, 研究員 2010: University of Yamanashi, 医学部, ポストドクター 2010: 自治医科大学, 医学部, ポストドクター 2009: University of Yamanashi, 大学院・医学工学総合研究部, 医学研究員 2007 – 2008: University of Yamanashi, Dept. Haematology, Assistant Professor … More 2007 – 2008: 山梨大学, 医学部附属病院, 助教 2007: 山梨大学, 医学部附属病院, 助教育 2006: 自治医科大学, 医学部, 研究員 Less
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Hematology / Neurology
Keywords	Principal Investigator 白血病 / 家族性血小板機能異常症 / 発現調節 / 遺伝子変異 / 白血球 / 家族性血小板減少症 / RUNX1 Except Principal Investigator SPG7 / SPG4 / siRNA … More / Spastin / Hereditary Spastic Paraplegia / HIF-1 / Vinblastine / anti-spastin antibody / Motor protein / ビンブラスチン / 抗spastin抗体 / JAK2 / 低酸素 / 骨髄増殖性疾患 / 造血幹細胞 / JAK2変異 / 低酸素環境 / SHP-2 / JAK2V617F / 骨髄増殖性腫瘍 / IGF-1 / survivin / 多発性骨髄腫 / FTY720 / protein phosphatase 2A / 分子標的治療 / オールトランスレチノイン酸 / FOXO3A / 急性前骨髄球性白血病 / アポトーシス / 寿命関連遺伝子 / 薬剤耐性 / 抗癌薬 / 白血病 / 血液内科学 Less

Hypoxia attenuates growth of MPN cells through suppression of SHP-2 expression and subsequent inhibition of JAK2V617F activity
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Analysis of the mechanisms of RUNX1 gene regulation in the pathogenesis of leukemiaPrincipal Investigator
- Principal Investigator
  
  SAKOE Kumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Development of novel therapeutic strategy for targeting transcription factors expressed in cancer stem cells
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
An analysis of molecular mechanism underlying spastin-induced spastic paraplegia and a strategy for the development of targeted therapies for the disease
- Principal Investigator
  
  TAKIYAMA Yoshihisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Jichi Medical University

All 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] Heat shock proteins and neurodegenetative diseases.Heat-Shock□Proteins:New Research2008
- Author(s)
  Sakoe K
- Publisher
  Nova Science Publishers(USA)(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590954
[Book] Spastic paraplegia type 4(SPG4).Advances in spinocerebellar degeneration and spastic paraplegia2008
- Author(s)
  Sakoe K
- Publisher
  Research Signpost(India)(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590954
[Book] Heat Shock Proteins : New Research, Nova Science2008
- Author(s)
  Kumi Sakoe, Yoshihisa Takiyama
- Total Pages
  513
- Publisher
  Publishers
- Data Source
  KAKENHI-PROJECT-20591114
[Book] Heat Shock Proteins : New Research2008
- Author(s)
  Kumi Sakoe
- Total Pages
  513
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-20591114
[Book] Heat shock proteins and neurodegenetative diseases.Heat-Shock□ Proteins:International Research2008
- Author(s)
  Sakoe K
- Publisher
  Nova Science Publishers(USA)
- Data Source
  KAKENHI-PROJECT-18590954
[Book] Spastic paraplegia type 4(SPG4).Advances in spinocerebellar degeneration and spastic paraplegia.2008
- Author(s)
  Sakoe K
- Publisher
  Research Signpost(India)
- Data Source
  KAKENHI-PROJECT-18590954
[Journal Article] NF-κB mediates aberrantactivation of HIF-1 in malignantlymphoma2010
- Author(s)
  Qiao Q, Nozaki Y, Sakoe K, Komatsu N, Kirito K
- Journal Title
  
  Exp Hematol
  
  Volume: 38(12) Pages: 1199-1208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia.2010
- Author(s)
  Sakoe Y
- Journal Title
  
  Blood (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010
- Author(s)
  Sakoe Y
- Journal Title
  
  Blood
  
  Volume: 115 Pages: 3787-3795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] FOXO3A as a key molecule forall-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010
- Author(s)
  Sakoe Y, Sakoe K, Kirito K, Ozawa K, Komatsu N
- Journal Title
  
  Blood
  
  Volume: 115(18) Pages: 3787-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] NF-κB mediates aberrant activation of HIF-1 in malignant lymphoma2010
- Author(s)
  Qiao Q, Nozaki Y, Sakoe K, Komatsu N, Kirito K.
- Journal Title
  
  Exp Hematol 38
  
  Pages: 1199-1208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010
- Author(s)
  Sakoe Y, Sakoe K, Kirito K, Ozawa K, Komatsu N.
- Journal Title
  
  Blood 115
  
  Pages: 3787-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia.2010
- Author(s)
  Sakoe Y
- Journal Title
  
  Blood (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myelomacells to melphalan2009
- Author(s)
  Hu Y, Kirito K, Yoshida K, MitsumoriT, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N
- Journal Title
  
  Molecular cancer therapeutics
  
  Volume: 8 Pages: 2329-2338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] Inhibition of HIF-1 function enhances the sensitivity of multiple myeloma cells to melphalan2009
- Author(s)
  ongzhen Hu, Kirito K, Yoshida K, Mitsumori T, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N.
- Journal Title
  
  Molecular cancer therapeutics 8
  
  Pages: 2329-2338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] Heat shock proteins and neurodegenerative diseases : New Research2008
- Author(s)
  Sakoe, K., Takiyama, Y
- Journal Title
  
  Heat-Shock Proteins : Internal Research. Nova Science Publishers, NY, USA(In : E. Morel and C. Vincent, eds.) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590954
[Journal Article] Spastic paraplegia type 4(SPG4)2008
- Author(s)
  Sakoe, K., et. al.
- Journal Title
  
  Advances in spinocerebellar degeneration and spastic paraplegia. Research Signpost, India(In : Y. Takiyama, et. al. eds.) (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590954
[Journal Article] A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies.2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N.
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Presentation] Lipid RaftはリツキシマブによるHIF-1活性化を規定する2011
- Author(s)
  野崎由美、Qiao Qiao、迫江公己、小松則夫、桐戸敬太
- Organizer
  第8回がんとハイポキシア研究会
- Place of Presentation
  札幌市
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] リツキシマブによるHIF-1活性化にはLipid Raftが関与する2010
- Author(s)
  野崎由美、Qiao Qiao、迫江公己、小松則夫、桐戸敬太
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] Impact of Protein Phosphatase PP2A on ATRA-Induced Activation of FoxO3a In Acute Promyelocytic Leukemia Cells2010
- Author(s)
  迫江公己, 他
- Organizer
  ASH Annual Meeting and Exposition
- Place of Presentation
  ORLAND, FL
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-20591114
[Presentation] リツキシマブはHIF-1を介して抗アポトーシス蛋白Survivinを誘導する2009
- Author(s)
  野崎由美,桐戸敬太, QiaoQiao,迫江公己,小松則夫
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都府
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-12008
- Author(s)
  Keita Kirito, Kozue Yoshida, Yongzhen Hu, Qiao Qiao, Kumi Sakoe, and Norio Komatsu
- Organizer
  第50回米国血液学会
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-18390282
[Presentation] RUNX1 の発現調節異常による白血病発症のメカニズムの解析2008
- Author(s)
  桐戸敬太、迫江公己, 他
- Organizer
  日本臨床血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591114
[Presentation] An analysis of molecular mechanism underlying spastin-induced spastic paraplegia(in Japanese)2007
- Author(s)
  Sakoe, K., et. al.
- Organizer
  The 48th annual meeting of Japan Neurology Society
- Place of Presentation
  Nagoya
- Year and Date
  2007-05-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590954
[Presentation] Spastin蛋白の機能解析2007
- Author(s)
  迫江公己
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590954

1. KIRITO Keita (90306150)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. KOMATSU Norio (50186798)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. KUNITAMA Masae (60397297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAGASHIMA Takahiro (10343443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MITSUMORI Toru (80377514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKIYAMA Yoshihisa (00245052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 滝山嘉久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakoe Kumi 迫江 公己

SAKOE Kumi 迫江 公己

Research Projects

Research Products

Co-Researchers

Hypoxia attenuates growth of MPN cells through suppression of SHP-2 expression and subsequent inhibition of JAK2V617F activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanisms of RUNX1 gene regulation in the pathogenesis of leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic strategy for targeting transcription factors expressed in cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An analysis of molecular mechanism underlying spastin-induced spastic paraplegia and a strategy for the development of targeted therapies for the disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Heat shock proteins and neurodegenetative diseases.Heat-Shock□Proteins:New Research2008

Author(s)

Publisher

Description

Data Source

[Book] Spastic paraplegia type 4(SPG4).Advances in spinocerebellar degeneration and spastic paraplegia2008

Author(s)

Publisher

Description

Data Source

[Book] Heat Shock Proteins : New Research, Nova Science2008

Author(s)

Total Pages

Publisher

Data Source

[Book] Heat Shock Proteins : New Research2008

Author(s)

Total Pages

Publisher

Data Source

[Book] Heat shock proteins and neurodegenetative diseases.Heat-Shock□ Proteins:International Research2008

Author(s)

Publisher

Data Source

[Book] Spastic paraplegia type 4(SPG4).Advances in spinocerebellar degeneration and spastic paraplegia.2008

Author(s)

Publisher

Data Source

[Journal Article] NF-κB mediates aberrantactivation of HIF-1 in malignantlymphoma2010

Author(s)

Journal Title

Data Source

[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia.2010

Author(s)

Journal Title

Data Source

[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010

Author(s)

Journal Title

Data Source

[Journal Article] FOXO3A as a key molecule forall-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010

Author(s)

Journal Title

Data Source

[Journal Article] NF-κB mediates aberrant activation of HIF-1 in malignant lymphoma2010

Author(s)

Journal Title

Data Source

[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010

Author(s)

Journal Title

Sakoe Kumi 迫江公己

SAKOE Kumi 迫江公己