KOMATSU Norio 小松則夫

Researcher Number	50186798
Other IDs
External Links
Affiliation (Current)	2020: 順天堂大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2009 – 2020: 順天堂大学, 医学部, 教授 2017: 順天堂大学, 医学部, 血液学講座 2008: 山梨大学, 大学院・医学工学統合研究部, 教授 2008: University of Yamanashi, 大学院・医学工学総合研究部, 教授 2004 – 2007: 山梨大学, 医学部附属病院, 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Hematology / Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Hematology / Hematology / Kidney internal medicine / Basic Section 54010:Hematology and medical oncology-related / Biological Sciences / Laboratory medicine / Tumor therapeutics / Pharmacology in pharmacy / Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator UT-7 / GATA-1 / FKHRL1 / 細胞周期 / トロンボポエチン / EPO / APL / アポトーシス / エリスロポエチン / ATRA … More Except Principal Investigator 造血幹細胞 / 造血因子 / calreticulin / 白血病 / 骨髄増殖性腫瘍 / HIF-1 / JAK2 / apoptosis / アポトーシス / シグナル伝達 / 細胞増殖 / エリスロポエチン / erythropoietin / thrombopoietin / 原発性骨髄線維症 / サイトカイン / 受容体 / 糖代謝 / ミトコンドリア / 活性酸素 / 遺伝子変異 / 染色体分析 / 造血細胞コロニー / CD34 / hemopoietic stem cells / monoclonal antibody / hemopoietic stem cell / hemopoietic factor / megakaryocytic cell line / erythropoietin receptor / hemopoietic stem cell disorders / 培養血管平滑筋細胞 / 透析患者 / 血管平滑筋細胞 / hypertension / cAMP / STAT5 / STAT3 / Bcl-xL / glucose / mitochondria / primary myelofibrosis / ruxolitinib / ルキソリチニブ / MPL / 本態性血小板血症 / 変異型CALR / キナーゼ / 転写因子 / 細胞分化 / Warbrug効果 / PDK-1 / グルコース / PDK1 / 解糖 / GLUT1 / RUNX1 / 家族性血小板減少症 / 白血球 / 発現調節 / 家族性血小板機能異常症 / JAK2V617F / SHP-2 / 低酸素環境 / JAK2変異 / 骨髄増殖性疾患 / 低酸素 / 慢性骨髄性白血病 / BCR/ABLキメラ遺伝子 / 病態モニタリング / 病態モニタリング技術 / BCR/ABL融合点 / キメラ遺伝子 / 組換ウイルス / モノクロ-ナル抗体 / Cーkit / ムコ多糖 / 脾コロニ- / 抗白血病細胞抗体 / cーkit / WGA / CD33 / DIF / 破骨細胞 / hemopoietic growth factors / c-kit / mucopolysaccharide / spleen colony / anti-leukemic cell antibody / 造血因子受容体 / 巨核球細胞株 / チロシン燐酸化 / エリスロポエチン受容体 / 幹細胞異常血液疾患 / アポトーシスと造血 / チロシンフォスファターゼ / receptor / tyrosine phosphorylation / 巨核球株細胞 / 赤芽球分化 / STAT転写因子群 / GATA-1 / 赤白血病 / erythropoietin gene / transcription factor / 細胞内Ca濃度 / 血管収縮物質 / 血管收縮物質 / 一酸化窒素 / 動脈硬化 / 血管のリモデリング / IL-1β / 一酸化窒素合成酵素 / hemodialysis / vascular smooth muscle cell / intracellular calcium / nitric oxide / vasoconstrictive substance / 情報伝達 / 高血圧 / 血管平滑筋 / マップキナーゼ系 / サイクリックAMP / 血管内皮前駆細胞 / 心血管系合併症 / 血管新生 / VEGF / MAPK / protein kinase A / signal transuduction / vasular smooth muscle cell / MAPK system / endothelial progenitor cells / トロンボポイエチン / 体外増幅 / 自己複製 / STAT / hematopoietic stem cell / self-renewal / MAPキナーゼ / カスパーゼ / MAPキナゼ / MAP kinase / caspase / TPO / TRAIL / PI3キナーゼ / Hematopoietic stem cell / ROS / flavonoid / ポリフェノール / Thrombopoietin / reactive oxygen species / hematopoietic stem cells / P13-kinase / 白血病細胞表面抗原 / モノクローナル抗体による白血病細胞除去 / 造血幹細胞濃縮 / イソプロテノーによる造血幹細胞の分化増殖 / AAABC療法 / FCMによる赤血球抗原の解析 / モノクローナル抗体による白血病細胞除 / イソプロテノールによる凍結解凍骨髄細胞の分化増殖の促進 / 自家骨髄移植法におけるAAABC療法 / T cell depletion / Tumor cell purging / Tumor spesific monoclonal antibodies / Bone marrow transplantation / AAABC therapy / リンパ球の起源 / インターリユキン5 / 巨核球産生 / 発癌ウイルス / 染色体 / 幹細胞の濃縮 / 造血因子遺伝子挿入 / 巨核球性白血病株 / 造血支株細胞 / リンパ球の超源 / MN血液型 / インターリューキン5 / インターリューキン6 / 無血清培養 / 単細胞培養 / hemopoietic factors / insertion of hemopoietic factor genes / megakaryoblastic cell line / hemopoietic stromal cells / lymphocyte differerentiation / アナポコーシス / 治療 / モノクローナル抗体 / 細胞死 / 汎HLA- class II / 細胞骨格 / 悪性リンパ腫 / 成人T細胞白血病 / Anapocosis / therapy / cell death / lymphoma / Adult T cell Leukemia / humanized m Ab / 悪性リンパ腫治療抗体 / NKリンフォーマ / 抗体治療薬 / MHC classs II / Death Receptor / macrolide / myelofibrosis / thrombopietin / autophagy / オートファジー / マクロライド / サイトカイン受容体 / 分子シャペロン / トロンボポエチン / CALR / Calreticulin / アナグレリド / non-responder / 個別化治療 / 薬剤反応性 / ドライバー変異 / 骨髄線維症 / iPS細胞 / カルレティキュリン / 奇形腫 / 免疫不全マウス / 疾患iPS細胞 / UT7/TPO / ER stress / JAK阻害薬 / ERストレス / 低分子化合物 Less

本態性血小板血症に特異的な転写ネットワークによる細胞腫瘍化メカニズムの解明Principal InvestigatorOngoing
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
変異型CALRのホモ多量体化を標的とした治療概念の確立Ongoing
- Principal Investigator
  
  荒木真理人
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
ERストレスを介した新規骨髄線維症腫瘍クローン廃絶法の開発Ongoing
- Principal Investigator
  
  後藤明彦
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Juntendo University
CALR遺伝子変異により発症する骨髄増殖性腫瘍に対する新規治療戦略の開発Ongoing
- Principal Investigator
  
  楊インジェ
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
本態性血小板血症の遺伝子情報に基づく個別化治療の実現Ongoing
- Principal Investigator
  
  高橋晴美
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Meiji Pharmaceutical University
家族内発症例の遺伝的要因の同定を基盤とした骨髄増殖性腫瘍発症機序の解明Principal InvestigatorOngoing
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Elucidation of molecular mechanism of cytokie receptor activation by mutant CALR
- Principal Investigator
  
  ARAKI MARITO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Establishment of in vitro model for essential thrombocythemia by mutant calreticulin
- Principal Investigator
  
  MIZUKAMI Yoshihisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Establishment of therapeutic mAbs for malignant lymphoma
- Principal Investigator
  
  MATSUOKA Shuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Juntendo University
Selective elimination of tumor clones of primary myelofibrosis based on drug repositioning
- Principal Investigator
  
  Gotoh Akihiko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Juntendo University
Identification of promising marker(s) for essential thrombocythemia diagnosis by differential gene expression approachPrincipal Investigator
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Sirtuin阻害による急性前骨髄球性白血病細胞の分化誘導Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
A novel approach for monitoring the minimal residual disease in chronic myeloid leukemia
- Principal Investigator
  
  Sato Eriko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Juntendo University
ＡＴＲＡによるＡＰＬ細胞の分化誘導の分子メカニズムPrincipal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Development of the new treatment strategy of ATRA-resistant APL using PP2A-FOXO3A activation pathwayPrincipal Investigator
- Principal Investigator
  
  KOMATSU NORIO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Hypoxia attenuates growth of MPN cells through suppression of SHP-2 expression and subsequent inhibition of JAK2V617F activity
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Analysis of the mechanisms of RUNX1 gene regulation in the pathogenesis of leukemia
- Principal Investigator
  
  SAKOE Kumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Role of glucose metabolism in hematological malignancy
- Principal Investigator
  
  KEITA Kirito
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Development of novel therapeutic strategy for targeting transcription factors expressed in cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
抗白血病薬によるTRAIL発現誘導と薬剤感受性Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
ホメオボックスHOXA9によるHOXB4の機能抑制と白血病発症Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
Thrombopoietin (TPO) regulates HIF-la levels through generation of mitochondrial reactive oxygen species
- Principal Investigator
  
  KIRITO Keita
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
FKHRL1による白血病細胞増殖抑制機構Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
白血病細胞のdormancy誘導におけるFKHRL1転写因子の役割Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
The development of targeted therapies using FKHRL1 for the treatment of leukemiaPrincipal Investigator
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
  Jichi Medical University
慢性骨随生白血病のSTI571耐性獲得におけるFKHRL1転写因子の役割Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Role of STAT5 in regulation of hematopoietic stem cell function
- Principal Investigator
  
  IWAMA Atsushi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  THE UNIVERSITY OF TOKYO
Gene therapy for chronic granulomatous disease combined with in vivo expansion of transduced hematopoietic cells.
- Principal Investigator
  
  MORI Masaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
FKHRL1転写因子の機能解析と血液疾患モデルの樹立Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Invesigation on signal transduction of erythropoietin in vascular smooth muscle cells
- Principal Investigator
  
  KUSANO Eiji
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Jichi Medical School
レチノイン酸による白血病細胞の赤血球分化決定機構の解析Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Establishment of model system for hematological disorders associated with mutated signal transduction moleculesPrincipal Investigator
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
造血細胞のシグナル伝達
- Principal Investigator
  
  宮島篤
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Invesigation on cellular mechanism of erythropoietin induced hypertension
- Principal Investigator
  
  KUSANO Eiji
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Jichi Medical School
赤芽球分化と巨核球分化決定機構の解析Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
analysis of molecular mechanism of hematopoiesis and hematological disordersPrincipal Investigator
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jich Medical School
赤芽球と巨核球分化の振り分け機構の解析Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
トロンボポエチン受容体と細胞内シグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
エリスロポエチンシグナル伝達分子異常と造血障害の病態解析Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
トロンボポエチン細胞内シグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Molecular control of the regulation of hemopoiesis and clinical application
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  jichi Medical School
エリスロポイエチン受容体遺伝子構造異常と造血障害Principal Investigator
- Principal Investigator
  
  小松則夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
Characterization of 85Kd protein tyrosine phosphorylated by erythropoietin stimulationPrincipal Investigator
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Analysis of collected primitive hemopoietic stem cells and its clinical application
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Isolation concentration, and preservation of hemopoietic stem cells and its clinical
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
造血幹細胞の分化と白血病はどのようにかかわりをもつか?
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
Studies on multipotent stem cell clifferentiation using newly developed techniques an its clinical applications.
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  JICHI MEDICAL SCHOOL
T cell and tumor cell purging of marrow cell suspension using monoclonal antibodies - Effect of technique
- Principal Investigator
  
  AMEMIYA Youichi
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School

[Book] WHO分類改定第4版による白血病・リンパ系腫瘍の病態学2019
- Author(s)
  木崎昌弘、田丸淳一、朝長万左男、小松則夫、吉岡智子，高橋直人，枝廣陽子，幣光太郎，下田和哉，水木満佐央，金倉譲，宮本敏浩，桐戸敬太，宮崎泰司，長谷川大輔，真部淳，南谷泰仁，麻生範雄，清井仁，佐々木伸也
- Total Pages
  527
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17H04211
[Book] WHO血液腫瘍分類　WHO分類2017をうまく活用するために2018
- Author(s)
  直江知樹、小松則夫、宮崎泰司、中村栄男、飯田真介、大島孝一、木下朝博、吉野正
- Total Pages
  463
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-17H04211
[Book] 真性赤血球増加症専門家による　私の治療.2017
- Author(s)
  小松則夫.
- Total Pages
  2
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-17H04211
[Book] 本態性血小板血症専門家による　私の治療.2017
- Author(s)
  小松則夫.
- Total Pages
  2
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-17H04211
[Book] これからの骨髄増殖性腫瘍の基礎研究と臨床のゴール.2017
- Author(s)
  小松則夫, 桐戸敬太, 荒木真理人
- Total Pages
  14
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-17H04211
[Book] 骨髄線維症（MF）～分子病態の解明から新規治療薬の開発まで～序～骨髄線維症の現状と展望～2017
- Author(s)
  小松則夫.
- Total Pages
  5
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-17H04211
[Book] インターフェロンの復活.2017
- Author(s)
  小松則夫
- Total Pages
  8
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-17H04211
[Book] 骨髄増殖性腫瘍の病態と治療20142014
- Author(s)
  小松則夫
- Publisher
  日本内科学会雑誌
- Data Source
  KAKENHI-PROJECT-23591407
[Book] Annual Review血液、真性赤血球増加症の心血管イベントと治療強度20142014
- Author(s)
  小松則夫
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 内科学第10版2013
- Author(s)
  小松則夫
- Total Pages
  12
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 内科学第10版赤血球増加症の原因と分類・相対的赤血球増加症・真性多血症・本態性血小板血症20132013
- Author(s)
  小松則夫
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 改訂第8版内科学書6血液・造血器疾患・神経疾患、本態性血小板血症・先天性家族性血小板血症・二次性(反応性)血小板増加症20132013
- Author(s)
  小松則夫
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 臨床血液2013
- Author(s)
  小松則夫
- Total Pages
  8
- Publisher
  日本血液学会
- Data Source
  KAKENHI-PROJECT-23591407
[Book] ここまできた白血病/MDS治療本態性血小板血症20132013
- Author(s)
  小松則夫
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 別冊:血液症候群IIIーその他の血液疾患を含めてー真性赤血球増加症20132013
- Author(s)
  小松則夫
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-23591407
[Book] Annual Review血液2013
- Author(s)
  小松則夫
- Total Pages
  9
- Publisher
  中外医学社
- Data Source
  KAKENHI-PUBLICLY-25118725
[Book] Annual Review血液2013
- Author(s)
  小松則夫
- Total Pages
  9
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591407
[Book] カラーテキスト血液病学第2版2013
- Author(s)
  小松則夫
- Total Pages
  17
- Publisher
  中外医学社
- Data Source
  KAKENHI-PUBLICLY-25118725
[Book] 改訂第8版内科学書6　血液・造血器疾患2013
- Author(s)
  小松則夫
- Total Pages
  5
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 日本臨床2013
- Author(s)
  小松則夫
- Total Pages
  8
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 改訂第8版内科学書6　血液・造血器疾患2013
- Author(s)
  小松則夫
- Total Pages
  5
- Publisher
  中山書店
- Data Source
  KAKENHI-PUBLICLY-25118725
[Book] 日本臨床2013
- Author(s)
  小松則夫
- Total Pages
  8
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PUBLICLY-25118725
[Book] カラーテキスト血液病学第2版2013
- Author(s)
  小松則夫
- Total Pages
  17
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 内科学第10版2013
- Author(s)
  小松則夫
- Total Pages
  12
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PUBLICLY-25118725
[Book] 臨床血液2013
- Author(s)
  小松則夫
- Total Pages
  8
- Publisher
  日本血液学会
- Data Source
  KAKENHI-PUBLICLY-25118725
[Book] カラーテキスト血液病学第2版、骨髄増殖性腫瘍20132013
- Author(s)
  小松則夫
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 骨髄増殖性腫瘍、カラー版内科学20122012
- Author(s)
  小松則夫
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-23591407
[Book] 血液専門医テキスト2011
- Author(s)
  桐戸敬太・小松則夫
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591197
[Book] Mol Biol.2004
- Author(s)
  Komatsu, N
- Total Pages
  13
- Publisher
  Culture of megakaryocytic cell lines : uses and limitations. Methods.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390306
[Book] Mol Biol.2004
- Author(s)
  Komatsu, N
- Total Pages
  13
- Data Source
  KAKENHI-PROJECT-15390306
[Book] Mol Biol. (Culture of megakaryocytic cell lines : uses and limitations. Methods.)2004
- Author(s)
  Komatsu, N
- Total Pages
  13
- Data Source
  KAKENHI-PROJECT-16022255
[Journal Article] Hommomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation.2019
- Author(s)
  Araki Marito、Yang Yinjie、Imai Misa、Mizukami Yoshihisa、Kihara Yoshihiko、Sunami Yoshitaka、Masubuchi Nami、Edahiro Yoko、Hironaka Yumi、Osaga Satoshi、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 33 Pages: 122-131
- DOI
  10.1038/s41375-018-0181-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16100, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Journal Article] Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy2019
- Author(s)
  Fukuda Yasutaka、Araki Marito、Yamamoto Kouji、Morishita Soji、Inano Tadaaki、Misawa Kyohei、Ochiai Tomonori、Edahiro Yoko、Imai Misa、Yasuda Hajime、Gotoh Akihiko、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Haematologica
  
  Volume: 印刷中
- DOI
  10.3324/haematol.2018.208876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972
[Journal Article] Meet the MPN experts in EHA　フィラデルフィア染色体陰性MPNの診断・治療の課題と将来展望 MPNを巡る臨床的課題と将来展望を語る2018
- Author(s)
  小松則夫, Kiladjan JJ, Roy L, Shih L-Y, Chen C-C, 後藤明彦
- Journal Title
  
  血液フロンティア
  
  Volume: 28 Pages: 263-267
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] Meet the MPN experts in EHA　フィラデルフィア染色体陰性MPNの診断・治療の課題と将来展望 MPNを巡る臨床的課題と将来展望を語る(座談会)2018
- Author(s)
  小松則夫, Kiladjian Jean-Jacques, ROY Lydia, Shih Lee-Yung, Chen Chin-Cheng, 後藤明彦
- Journal Title
  
  血液フロンティア
  
  Volume: 28 Pages: 263-267
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] Skewed megakaryopoiesis in human iPS cell-derived hematopoietic progenitor cells harboring calreticulin mutations2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19587
[Journal Article] Effect of ruxolitinib therapy on the quality-of-life of Japanese patients with myelofibrosis.2018
- Author(s)
  Oritani K, Ohishi K, Okamoto S, Kirito K, Komatsu N, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Okada H, Amagasaki T, Wakase S, Shimozuma K, Akashi K.
- Journal Title
  
  Curr Med Res Opin.
  
  Volume: 34 Pages: 531-537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04211
[Journal Article] Transfusion independence achieved with pomalidomide therapy in a patient with primary myelofibrosis2018
- Author(s)
  枝廣陽子, 後藤明彦, 稲野資明, 筒井深雪, 築根豊, 安田肇, 小松則夫
- Journal Title
  
  Jpn. J. Clin. Hematol.
  
  Volume: 59 Issue: 3 Pages: 323-325
- DOI
  10.11406/rinketsu.59.323
- NAID
  130006627427
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972
[Journal Article] Mutational subtypes of JAK2 and CALR correlate with different clinical features in Japanese patients with myeloproliferative neoplasms2018
- Author(s)
  Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
- Journal Title
  
  Int J Hematol.
  
  Volume: 印刷中 Pages: 673-680
- DOI
  10.1007/s12185-018-2421-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17H04211
[Journal Article] Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations.2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihsa Mizukami, Misa Imai, Soji Morishita, Kyohei Misawa, Tomonori Ochiai, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Journal Title
  
  Br J Haematol.
  
  Volume: 印刷中 Pages: 791-802
- DOI
  10.1111/bjh.15266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11017, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Journal Article] Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis2018
- Author(s)
  Kirito K, Okamoto S, Ohishi K, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Oritani K, Akashi K, Okada H, Amagasaki T, Suzuki K, Yonezu T, Komatsu N
- Journal Title
  
  Int J Hematol.
  
  Volume: 107(1) Pages: 92-97
- DOI
  10.1007/s12185-017-2332-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09872, KAKENHI-PROJECT-17H04210, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K09470
[Journal Article] Effect of ruxolitinib therapy on the quality-of-life of Japanese patients with myelofibrosis2018
- Author(s)
  Oritani K, Ohishi K, Okamoto S, Kirito K, Komatsu N, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Okada H, Amagasaki T, Wakase S, Shimozuma K, Akashi K
- Journal Title
  
  Current Medical Research and Opinion
  
  Volume: 34 Pages: 531-537
- DOI
  10.1080/03007995.2017.1415874
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08894, KAKENHI-PROJECT-16K09872, KAKENHI-PROJECT-15K09470, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17H04210, KAKENHI-PROJECT-15K07972
[Journal Article] Multiple Placental Infarcts in a Pregnant Woman with Essential Thrombocythemia2018
- Author(s)
  Edahiro Yoko、Ando Jun、Suzuki Toshifumi、Fukumura Yuki、Masuda Azuchi、Sakayori Shiori、Takeda Jun、Maruyama Yojiro、Makino Shintaro、Itakura Atsuo、Komatsu Norio
- Journal Title
  
  Internal Medicine
  
  Volume: 57 Issue: 24 Pages: 3647-3650
- DOI
  10.2169/internalmedicine.1311-18
- NAID
  130007432644
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K07273, KAKENHI-PROJECT-15K07972
[Journal Article] The 2014 BCSH criteria and the 2016 WHO criteria for essential thrombocythemia: A comparison in a large-scale cohort2018
- Author(s)
  Ochiai T, Yasuda H, Araki M, Misawa K, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
- Journal Title
  
  Eur J Haematol.
  
  Volume: 印刷中 Pages: 544-549
- DOI
  10.1111/ejh.13041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-15K19559, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17H04211
[Journal Article] Meet the MPN experts in EHA　フィラデルフィア染色体陰性MPNの診断・治療の課題と将来展望 MPNを巡る臨床的課題と将来展望を語る(座談会)2018
- Author(s)
  小松則夫(順天堂大学血液内科学), Kiladjian Jean-Jacques, ROY Lydia, Shih Lee-Yung, Chen Chin-Cheng, 後藤明彦
- Journal Title
  
  血液フロンティア
  
  Volume: 28 Pages: 263-267
- Data Source
  KAKENHI-PROJECT-18K06690
[Journal Article] Mutant molecular chaperone activates cytokine receptor as a homomultimer2018
- Author(s)
  Araki Marito、Komatsu Norio
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 35201-35202
- DOI
  10.18632/oncotarget.26221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Journal Article] Multiple Placental Infarcts in a Pregnant Woman with Essential Thrombocythemia.2018
- Author(s)
  Edahiro Y, Ando J, Suzuki T, Fukumura Y, Masuda A, Sakayori S, Takeda J, Maruyama Y, Makino S, Itakura A, Komatsu N.
- Journal Title
  
  Internal Medicine.
  
  Volume: 57 Pages: 3647-3650
- NAID
  130007531198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04211
[Journal Article] The impact of myeloproliferative neoplasms (MPNs) on patient quality of life and productivity: results from the international MPN Landmark survey.2017
- Author(s)
  Harrison CN, Koschmieder S, Foltz L, Guglielmelli P, Flindt T, Koehler M, Mathias J, Komatsu N, Boothroyd RN, Spierer A, Perez Ronco J, Taylor-Stokes G, Waller J, Mesa RA.
- Journal Title
  
  Ann Hematol.
  
  Volume: 96 Pages: 1653-1665
- DOI
  10.1007/s00277-017-3082-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04211
[Journal Article] Novel molecular mechanism of cellular transformation by a mutant molecular chaperone in myeloproliferative neoplasms.2017
- Author(s)
  Araki Marito、Komatsu Norio
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Pages: 1907-1912
- DOI
  10.1111/cas.13327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17H04211
[Journal Article] Somatic mutations of calreticulin in myeloproliferative neoplasms.2017
- Author(s)
  Imai Misa、Araki Marito、Komatsu Norio
- Journal Title
  
  Int J Hematol.
  
  Volume: 105 Pages: 743-747
- DOI
  10.1007/s12185-017-2246-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-17H04211
[Journal Article] The 2016 WHO diagnostic criteria for polycythemia vera renders an accurate diagnosis to a broader range of patients including masked polycythemia vera: comparison with the 2008 WHO diagnostic criteria.2017
- Author(s)
  Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
- Journal Title
  
  American journal of hematology
  
  Volume: 92
- DOI
  10.1002/ajh.24752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K19559
[Journal Article] Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis.2017
- Author(s)
  Komatsu N, Kirito K, Shimoda K, Ishikawa T, Ohishi K, Ohyashiki K, Takahashi N, Okada H, Amagasaki T, Yonezu T, Akashi K.
- Journal Title
  
  Int J Hematol
  
  Volume: 105 Pages: 309-317
- DOI
  10.1007/s12185-016-2130-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis.2017
- Author(s)
  Komatsu N, Kirito K, Shimoda K, Ishikawa T, Ohishi K, Ohyashiki K, Takahashi N, Okada H, Amagasaki T, Yonezu T, Akashi K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 105 Pages: 309-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04211
[Journal Article] Gene mutations in myeloproliferative neoplasms2017
- Author(s)
  荒木真理, 森下総司, 小松則夫
- Journal Title
  
  Jpn. J. Clin. Hematol.
  
  Volume: 12 Issue: 12 Pages: 2526-2534
- DOI
  10.11406/rinketsu.57.2526
- NAID
  130005286786
- ISSN
  0485-1439, 1882-0824
- Year and Date
  2017-01-13
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] 9.Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms2017
- Author(s)
  Ueda K, Ikeda K, Ikezoe T, Harada-Shirado K, Ogawa K, Hashimoto Y, Sano T, Ohkawara H, Kimura S, Shichishima-Nakamura A, Nakamura Y, Shikama Y, Mori T, Mason PJ, Bessler M, Morishita S, Komatsu N, Shide K, Shimoda K, Koide S, Aoyama K, Oshima M, Iwama Aand Takeishi Y.
- Journal Title
  
  Ｂｌｏｏｄ　Ａｄｖａｎｃｅｓ
  
  Volume: 1 Pages: 1001-1001
- DOI
  10.1182/bloodadvances.2017004457
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09852, KAKENHI-PROJECT-17H04210, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K09457, KAKENHI-PROJECT-15K09483, KAKENHI-PROJECT-15K09484, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K19582
[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  Miyahara K, Kazama H, Kokuba H, Komatsu S, Hirota A, Takemura J, Hirasawa K,Moriya S, Abe A, Hiramoto M, Ishikawa T, Miyazawa K.
- Journal Title
  
  Int J Oncol
  
  Volume: 49 Pages: 1848-1858
- DOI
  10.3892/ijo.2016.3673
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387
[Journal Article] 2.Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016
- Author(s)
  Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O.
- Journal Title
  
  PLoS One.
  
  Volume: 11(3)
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06880
[Journal Article] 骨髄増殖性腫瘍を引き起こす変異型calreticulinによるTPO受容体の活性化.2016
- Author(s)
  今井美沙, 荒木真理人, 森下総司, 小松則夫.
- Journal Title
  
  血液内科
  
  Volume: 73 Pages: 789-793
- Data Source
  KAKENHI-PROJECT-16K09859
[Journal Article] Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.2016
- Author(s)
  Matsuoka S, Ishii Y, Nakao A, Abe M, Ohtsuji N, Momose S, Jin H, Arase H, Sugimoto K, Nakauchi Y, Masutani H, Maeda M, Yagita H, Komatsu N, Hino O.
- Journal Title
  
  PLoS One.
  
  Volume: 11(3)
- NAID
  120005838168
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06880
[Journal Article] Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms.2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N
- Journal Title
  
  Blood
  
  Volume: 127 Pages: 1307-1316
- DOI
  10.1182/blood-2015-09-671172
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-15K19559, KAKENHI-PROJECT-26893264
[Journal Article] 診断における遺伝子変異の意義と問題点2016
- Author(s)
  小松則夫
- Journal Title
  
  日本検査血液学会雑誌
  
  Volume: 17 Pages: 347-353
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] 骨髄増殖性腫瘍をひき起こす変異型calreticulinによるTPO受容体の活性化機構2016
- Author(s)
  今井美沙, 荒木真理人, 森下総司, 小松則夫
- Journal Title
  
  血液内科
  
  Volume: 73 Pages: 789-793
- NAID
  40021031814
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] 骨髄増殖性腫瘍の遺伝子変異　最近の知見.2016
- Author(s)
  荒木真理人, 森下総司, 小松則夫.
- Journal Title
  
  臨床血液.
  
  Volume: 57 Pages: 2526-2534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09859
[Journal Article] Reactivation of hepatitis B virus during treatment with hydroxyurea in an elderly patient with essential thrombocythemia.2015
- Author(s)
  Watanabe N, Yasuda H, Aota Y, Ando J, Aoyama T, Tanaka M, Gotoh A, Komatsu N.
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 15 Pages: 812-3
- DOI
  10.1111/ggi.12461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential thrombocythemia.2015
- Author(s)
  Shirane S, Araki M, Morishita S, Edahiro Y, Sunami Y, Hironaka Y, Noguchi M, Koike M, Sato E, Ohsaka A, Komatsu N.
- Journal Title
  
  Int J Hematol.
  
  Volume: 101 Pages: 148-53
- DOI
  10.1007/s12185-014-1721-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-26893264
[Journal Article] Melting curve analysis after T allele enrichment (MelcaTle) as a highly sensitive and reliable method for detecting the JAK2V617F mutation2015
- Author(s)
  Morishita S, Takahashi K, Araki M, Hironaka Y, Sunami Y, Edahiro Y, Tsutsui M, Ohsaka A, Tsuneda S, Komatsu N.
- Journal Title
  
  PLOS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0122003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-25860416, KAKENHI-PROJECT-26893264
[Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.2015
- Author(s)
  Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K
- Journal Title
  
  Int J Oncol
  
  Volume: Feb;46(2) Pages: 474-486
- DOI
  10.3892/ijo.2014.2773
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26430170, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972
[Journal Article] Current problems in the diagnosis of Philadelphia-negative myeloproliferative neoplasms in Japan2015
- Author(s)
  白根脩一、荒木真理人、森下総司、枝廣陽子、大阪顯通、小松則夫
- Journal Title
  
  Jpn. J. Clin. Hematol.
  
  Volume: 56 Issue: 7 Pages: 877-82
- DOI
  10.11406/rinketsu.56.877
- NAID
  130005093120
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-15K19559
[Journal Article] Usefulness of BCSH Criteria for Diagnosing Japanese Polycythemia Vera -Comparative Analysis with WHO 2008 Criteria-2015
- Author(s)
  Yahata Y, Gotoh A, Komatsu N
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 61 Pages: 287-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972
[Journal Article] JAK2V617F mutation status and allele burden in classical Ph-negative myeloproliferative neoplasms in Japan2014
- Author(s)
  EdahiroY, Morishita S, Takahashi K, Hironaka Y, Yahata Y, Sunami Y, Shirane S, Tsutsui M, Noguchi M, Koike M, Imai K, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Araki M, Komatsu N
- Journal Title
  
  Int J Hematol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Journal Article] JAK2V617F mutation status and allele burden in classical Ph-negative myeloproliferative neoplasms in Japan2014
- Author(s)
  EdahiroY, Morishita S, Takahashi K, Hironaka Y, Yahata Y, Sunami Y, Shirane S, Tsutsui M, Noguchi M, Koike M, Imai K, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Araki M, Komatsu N
- Journal Title
  
  International Journal of Hematology
  
  Volume: 99(5) Pages: 625-34
- DOI
  10.1007/s12185-014-1567-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407, KAKENHI-PROJECT-25860416, KAKENHI-PROJECT-26893264
[Journal Article] JAK2V617F mutation status and allele burden in classical Ph-negative myeloproliferative neoplasms in Japan2014
- Author(s)
  EdahiroY, Morishita S, Takahashi K, Hironaka Y, Yahata Y, Sunami Y, Shirane S, Tsutsui M, Noguchi M, Koike M, Imai K, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Araki M, Komatsu N.
- Journal Title
  
  Int J Hematol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118725
[Journal Article] An induced pluripotent stem cell-mediated and integration-free factor VIII expression system2013
- Author(s)
  Yakura y, et. al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 431 Pages: 336-341
- DOI
  10.1016/j.bbrc.2012.12.096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00264, KAKENHI-PROJECT-23591407, KAKENHI-PROJECT-23659040, KAKENHI-PROJECT-24659469, KAKENHI-PROJECT-24790974
[Journal Article] MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia2013
- Author(s)
  Baba T, Naka K, Morishita S, Komatsu N, Hirao A, Mukaida N.
- Journal Title
  
  J Exp Med
  
  Volume: 210 Pages: 2661-2673
- DOI
  10.1084/jem.20130112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407, KAKENHI-PUBLICLY-25118725, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25460492
[Journal Article] A Monoclonal Expansion of Epstein-Barr Virus-Infected Natural Killer Cells after Allogeneic Peripheral Blood Stem Cell Transplantation2013
- Author(s)
  Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N
- Journal Title
  
  J Clin Virol.
  
  Volume: 56 Pages: 150-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Journal Article] Rituximab activates Syk and AKT in CD20-positive B cell lymphoma cells dependent on cell membrane cholesterol levels.2013
- Author(s)
  Nozaki Y, Mitsumori T, Yamamoto T, Kawashima I, Shobu Y, Hamanaka S, Nakajima K, Komatsu N, Kirito K
- Journal Title
  
  Exp Hematol
  
  Volume: 41(8) Pages: 687-696
- DOI
  10.1016/j.exphem.2013.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407, KAKENHI-PUBLICLY-25118725
[Journal Article] A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation2013
- Author(s)
  Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N
- Journal Title
  
  J Clin Virol
  
  Volume: 56(2) Pages: 150-152
- DOI
  10.1016/j.jcv.2012.11.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407, KAKENHI-PUBLICLY-25118725
[Journal Article] Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells.2013
- Author(s)
  Sunami Y, Araki M, Hironaka Y, Morishita S, Kobayashi M, Liew EL, Edahiro Y, Tsutsui M, Ohsaka A, Komatsu N
- Journal Title
  
  PLOS ONE
  
  Volume: 8(2)
- DOI
  10.1371/journal.pone.0057633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407, KAKENHI-PROJECT-23800055, KAKENHI-PUBLICLY-25118725, KAKENHI-PUBLICLY-23118528
[Journal Article] Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes.2013
- Author(s)
  Suzuki HI
- Journal Title
  
  Leukemia.
  
  Volume: 27 Pages: 2107-2111
- DOI
  10.1038/leu.2013.121
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-23591407, KAKENHI-PROJECT-24689018, KAKENHI-PUBLICLY-25118725
[Journal Article] Expression of Epstein-Barr virus-encoded proteins in extranodal NK/T-cell Lymphoma, nasal type (ENKL): differences in biologic and clinical behaviors of LMP1-positive and -negative ENKL2012
- Author(s)
  Kanemitsu N,
- Journal Title
  
  Clin Cancer Res
  
  Volume: 18（8） Pages: 2164-2172
- DOI
  10.1158/1078-0432.ccr-11-2395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590338, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-23591407
[Journal Article] T/NK-cell type chronic active Epstein-Barr virus (EBV) disease in adults : an underlying condition for EBV-associated T/NK-cell lymphoma2012
- Author(s)
  Isobe Y, Aritaka N, Setoguchi Y, Ito Y, Kimura H, Hamano Y, Sugimoto K, Komatsu N
- Journal Title
  
  J Clin Pathol
  
  Volume: 65(3) Pages: 278-282
- DOI
  10.1136/jclinpath-2011-200523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407, KAKENHI-PROJECT-23591564, KAKENHI-PROJECT-24659493
[Journal Article] miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-1 7 producing immunophenotype to anaplastic large cell lymphoma2011
- Author(s)
  Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, et al
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 6881-6892
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23118528
[Journal Article] Alternately binding probe competitive PCR as a simple, cost-effective, and accurate quantification method for JAK2V617F allele burden in myeloproliferative neoplasms2011
- Author(s)
  Morishita S, Komatsu N, Kirito K, Koda AH, Sekiguchi Y, Tsuneda S, Noda N
- Journal Title
  
  Leuk Res.
  
  Volume: 35 Pages: 1632-1636
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23118528
[Journal Article] Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis.2011
- Author(s)
  Tabe Y, Kawase Y, Miyake K, Satoh N, Aritaka N, Isobe Y, Oshimi K, Komatsu N, Miida T, Ohsaka A
- Journal Title
  
  Clin Chem Lab Med.
  
  Volume: 49 Pages: 809-815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Journal Article] miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.2011
- Author(s)
  Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 6881-6892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Journal Article] Alternately binding probe competitive PCR as a simple2011
- Author(s)
  Morishita S, Komatsu N, Kirito K, Koda AH, Sekiguchi Y, Tsuneda S, Noda N
- Journal Title
  
  cost-effective, and accurate quantification method for JAK2V617F allele burden in myeloproliferative neoplasms Leukemia Research
  
  Volume: 35 Pages: 1632-1636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] Alternately binding probe competitive PCR as a simple, cost-effective, and accurate quantification method for JAK2V617F allele burden in myeloproliferative neoplasms.2011
- Author(s)
  Morishita S, Komatsu N, Kirito K, Koda AH, Sekiguchi Y, Tsuneda S, Noda N.
- Journal Title
  
  Leuk Res.
  
  Volume: 35 Pages: 1632-1636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Journal Article] Usefulness of systemic computed tomography (CT) scanning in the detection of malignant lymphadenopathy.2011
- Author(s)
  Ichikawa K, Sugimoto K, Isobe Y, Kuwatsuru R, Sasaki M, Horiguchi I, Komatsu N.
- Journal Title
  
  Medicine (Baltimore).
  
  Volume: 90 Pages: 396-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Journal Article] APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans.2011
- Author(s)
  Inoue T, Sugiyama D, Kurita R, Oikawa T, Kulkeaw K, Kawano H, Miura Y, Okada M, Suehiro Y, Takahashi A, Marumoto T, Inoue H, Komatsu N, Tani K
- Journal Title
  
  Humans. Stem Cell Rev.
  
  Volume: 7 Pages: 43-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Journal Article] FOXO3A as a key molecule for all-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010
- Author(s)
  Sakoe Y, Sakoe K, Kirito K, Ozawa K, Komatsu N.
- Journal Title
  
  Blood 115
  
  Pages: 3787-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] FOXO3A as a key molecule forall-trans retinoic acid-induced granulocytic differentiation and apoptosis in acute promyelocytic leukemia2010
- Author(s)
  Sakoe Y, Sakoe K, Kirito K, Ozawa K, Komatsu N
- Journal Title
  
  Blood
  
  Volume: 115(18) Pages: 3787-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] NF-κB mediates aberrant activation of HIF-1 in malignant lymphoma2010
- Author(s)
  Qiao Q, Nozaki Y, Sakoe K, Komatsu N, Kirito K.
- Journal Title
  
  Exp Hematol 38
  
  Pages: 1199-1208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] NF-κB mediates aberrantactivation of HIF-1 in malignantlymphoma2010
- Author(s)
  Qiao Q, Nozaki Y, Sakoe K, Komatsu N, Kirito K
- Journal Title
  
  Exp Hematol
  
  Volume: 38(12) Pages: 1199-1208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] Familial sideroblastic anemia associated with cardiac atrial septal defect.2009
- Author(s)
  Mori M, Nakamoto S, Akifuji Y, Tanaka T, Komatsu N, Hatake K, Ozawa K.
- Journal Title
  
  Am J Hematol 7
  
  Pages: 451-452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] Inhibition of HIF-1 function enhances the sensitivity of multiple myeloma cells to melphalan2009
- Author(s)
  ongzhen Hu, Kirito K, Yoshida K, Mitsumori T, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N.
- Journal Title
  
  Molecular cancer therapeutics 8
  
  Pages: 2329-2338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myelomacells to melphalan2009
- Author(s)
  Hu Y, Kirito K, Yoshida K, MitsumoriT, Nakajima K, Nozaki Y, Hamanaka S, Nagashima T, Kunitama M, Sakoe K, Komatsu N
- Journal Title
  
  Molecular cancer therapeutics
  
  Volume: 8 Pages: 2329-2338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] HIF-1prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-12009
- Author(s)
  Kirito K, Hu Y, Komatsu N
- Journal Title
  
  Cell cycle
  
  Volume: 8 Pages: 2844-2849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591197
[Journal Article] HIF-1 prevents the overproduction of mitochondrial ROS after cytokine stimulation through induction of PDK-12009
- Author(s)
  Kirito K, Hu Y, Komatsu N.
- Journal Title
  
  Cell cycle 8
  
  Pages: 2844-2849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies.2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] Identification of erythropoietin-induced microRNAs in hematopoietic cells during erythroid differentiation2008
- Author(s)
  Kosaka N, Sugiura K,Yamamoto Y, Yoshioka Y, Miyazaki H, Komatsu N, Ochiya T, Kato T.
- Journal Title
  
  Br J Haematol 142
  
  Pages: 293-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Regulation of erythropoiesis and pathogenesis of anemia2008
- Author(s)
  Komatsu N.
- Journal Title
  
  Nippon Rinsho 66
  
  Pages: 420-422
- NAID
  40015862583
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Thrombopoietin (TPO) regulates HIF-1a levels through generation of mitochondrial reactive oxygen species.2008
- Author(s)
  Yoshida K, Kirito K, Yongzhen H, Ozawa K, Kaushansky K, Komatsu N.
- Journal Title
  
  Int J Hematol 88
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591114
[Journal Article] Throrabopoietin (TPO) regulates HIF-lalpha levels through generation of mitochondrial reactive oxvgen species2008
- Author(s)
  Yoshida, K., Kirito, K., Yongzhen, H., Ozawa, K., Kaushansky, K., Komatsu, N.
- Journal Title
  
  Int J Hematol 88
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf22008
- Author(s)
  Nagai T, Kikuchi S, Ohmine K, Miyoshi T, Nakamura M, Kondo T, Furuyama K, Komatsu N, Ozawa K.
- Journal Title
  
  J Cell Biochem 104(2)
  
  Pages: 680-691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] .A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies2008
- Author(s)
  K. Kirito, K. Sakoe, D. Shinoda, Y. Takiyama, K. Kaushansky and N. Komatsu
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Thrombopoietin (TPO) regulates HIF-1a levels through generation of mitochondrial reactive oxygen species2008
- Author(s)
  Yoshida K, Kirito K, Yongzhen H,Ozawa K, Kaushansky K, Komatsu N.
- Journal Title
  
  Int J Hematol 88(1)
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N.
- Journal Title
  
  Haematologica 93
  
  Pages: 155-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies2008
- Author(s)
  Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N
- Journal Title
  
  Haematologica 93
  
  Pages: 155-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Regulation of erythropoiesis and pathogenesis of anemia.2008
- Author(s)
  Komatsu N
- Journal Title
  
  Nippon Rinsho 66
  
  Pages: 420-422
- NAID
  40015862583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species2008
- Author(s)
  Yoshida K, Kirito K, Yongzhen H, Ozawa K, Kaushansky K, Komatsu N
- Journal Title
  
  International journal of hematology 88
  
  Pages: 43-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Activation of FKHRL1 plays an important role in protecting erythroid cells from erythropoietin deprivation-induced apoptosis in a human erythropoietin-dependent leukemia cell line, UT-7/EPO2007
- Author(s)
  Uchida M, Kirito K, Endo H, Ozawa K, Komatsu N
- Journal Title
  
  International journal of hematology 86
  
  Pages: 315-24
- NAID
  10019990096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand2007
- Author(s)
  Kikuchi S, Nagai T, Kunitama M, Kirito K, Ozawa K, Komatsu N.
- Journal Title
  
  Cancer science 98
  
  Pages: 1949-58
- NAID
  10019996600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosisinducing ligand2007
- Author(s)
  Kikuchi S, Nagai T, Kunitama M, Kirito K, Ozawa K, Komatsu N.
- Journal Title
  
  Cancer Sci 98(12)
  
  Pages: 1949-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Activation of FKHRL1 plays an important role in protecting erythroid cells from erythropoietin deprivation-induced apoptosis in a human erythropoietin-dependent leukemia cell line2007
- Author(s)
  Uchida M, Kirito K, Endo H, Ozawa K, Komatsu N.
- Journal Title
  
  UT-7/EPO. Int J Hematol 86(4)
  
  Pages: 315-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Cloning and characterization of a human BCR/ABL-positive cell line2007
- Author(s)
  Miyoshi T, Nagai T, Kikuchi S, Ohmine K, Nakamura M, Hanafusa T, Komatsu N, Ozawa K.
- Journal Title
  
  K562/RR, resistant to the farnesyltransferase inhibition by tipifarnib. Exp Hematol 35(9)
  
  Pages: 1358-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Erythropoietin for the treatment of chemotherapy-induced anemia2007
- Author(s)
  Komatsu N.
- Journal Title
  
  Rinsho Ketsueki 48(10)
  
  Pages: 1435-41
- NAID
  10019829495
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] .Active FKHRL1 overcomes imatinib resistance in chronic myelogenous leukemia-derived cell lines via the production of tumor necrosis factor-related apoptosis-inducing ligand2007
- Author(s)
  S. Kikuchi, T. Nagai, M. Kunitama, K. Kirito, K. Ozawa and N. Komatsu
- Journal Title
  
  Cancer Science 98
  
  Pages: 1949-1958
- NAID
  10019996600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591103
[Journal Article] Erythropoietin for the treatment of chemotherapy-induced anemia2007
- Author(s)
  Komatsu N
- Journal Title
  
  Rinsho Ketsueki 48
  
  Pages: 1435-1441
- NAID
  10019829495
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] Suppression of RUNX1 by siRNA in megakaryocytic UT-7/GM cells2006
- Author(s)
  Okada Y, Nagai R, Matsuura E, Hoshika Y, Nakata E, Nagura H, Watanabe A, Komatsu N, Doi T.
- Journal Title
  
  Nucleic Acids Symposium Series 50
  
  Pages: 261-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] RUNX1 suppression induces megakaryocytic differentiation of UT-7/GM cells2006
- Author(s)
  R.Nagai, E.Matsuura, Y.Hoshika, E.Nakata, H.Nagura, A.Watanabe, N.Komatsu, Y.Okada, T.Doi.
- Journal Title
  
  Biochem Biophys Res Commun 345-1
  
  Pages: 78-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Suppression of RUNX1 by siRNA in megakaryocytic UT-7/GM cells.2006
- Author(s)
  Okada Y, Nagai R, Matsuura E, Hoshika Y, Nakata E, Nagura H, Watanabe A, Komatsu N, Doi T.
- Journal Title
  
  Nucleic Acids Symp Ser (Oxf) 50
  
  Pages: 261-262
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] RUNX1 suppression induces megakaryocytic differentiation of UT- 7/GM cells2006
- Author(s)
  Nagai R, Matsuura E, Hoshika Y, Nakata E, Nagura H, Watanabe A, Komatsu N, Okada Y, Doi T.
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 78-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390282
[Journal Article] RUNX1 suppression induces megakaryocytic differentiation of UT-7/GM cells2006
- Author(s)
  Nagai R, Matsuura E, Hoshika Y, Nakata E, Nagura H, Watanabe A, Komatsu N, Okada Y, Doi T.
- Journal Title
  
  Biochem Biophys Res Commun. 345・1
  
  Pages: 78-84
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Suppression of RUNX1 by siRNA in megakaryocytic UT-7/GM cells.2006
- Author(s)
  Okada Y, Nagai R, Matsuura E, Hoshika Y, Nakata E, Nagura H, Watanabe A, Komatsu N, Doi T
- Journal Title
  
  Nucleic Acids Symp Ser (Oxf) 50
  
  Pages: 261-262
- Data Source
  KAKENHI-PROJECT-17659291
[Journal Article] RUNX1 suppression induces megakaryocytic differentiation of UT-7/GM cells2006
- Author(s)
  Nagai R, Matsuura E, Hoshika Y, Nakata E, Nagura H, Watanabe A, Komatsu N, Okada Y, Doi T
- Journal Title
  
  Biochem Biophys Res Commun. 345・1
  
  Pages: 78-84
- Data Source
  KAKENHI-PROJECT-17659291
[Journal Article] Suppression of RUNX1 by siRNA in megakaryocytic UT-7/GM cells2006
- Author(s)
  Y.Okada, R.Nagai, E.Matsuura, Y.Hoshika, E.Nakata, H.Nagura, A.Watanabe, N.Komatsu, T.Doi.
- Journal Title
  
  Nucleic Acids Symp Ser (Oxf) 50
  
  Pages: 261-2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO2005
- Author(s)
  A.Yazaki, S.Tamaru, Y.Sasaki, N.Komatsu, H.wada, H.Shiku, M.Nishikawa.
- Journal Title
  
  Cell Signal 17-3
  
  Pages: 321-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Retropharyngeal abscess due to methicillin-resistant Staphylococcus aureus in a case of acute myeloid leukemia2005
- Author(s)
  K.Sato, T.Izumi, M.Toshima, T.Nagai, K.Muroi, N.Komatsu, K.Ozawa
- Journal Title
  
  Intern Med 44-4
  
  Pages: 346-9
- NAID
  10015461976
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Relative importance of apoptosis and cell cycle blockage in the synergistic effect of combined R115777 and imatinib treatment in BCR/ABL-positive cell lines2005
- Author(s)
  T.Miyoshi, T Nagai, K.Ohmine, M.Nakamura, Y.Kano, K.Muroi, N.Komatsu, K Ozawa
- Journal Title
  
  Biochem Pharmacol 69-11
  
  Pages: 1585-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha2005
- Author(s)
  K.Kirito, N.Fox, N.Komatsu, K.Kaushansky.
- Journal Title
  
  Blood 105-11
  
  Pages: 4258-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] TEL/ETV6 accelerates erythroid differentiation and inhibits megakaryocytic maturation in a human leukemia cell line UT-7/GM2005
- Author(s)
  W.Takahashi, K.Sasaki, N.Komatsu, K.Mitani.
- Journal Title
  
  Cancer Sci 96-340-348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] lron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion2005
- Author(s)
  T.Nagai, N.Komatsu, Y.Sakata, Y.Miura, K.Ozawa.
- Journal Title
  
  Intern Med 44-10
  
  Pages: 1090-2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Autologous gamete cryopreservation before hemopoietic stem cell transplantation2005
- Author(s)
  T.Nagashima, K.Muroi, C.Kawano-Yamamoto, T.Miyoshi, K.Ohmine, M.Toshima, A.Miyazato, M.Takatoku, T.Nagai, M.Mori, N.Komatsu, K.Ozawa.
- Journal Title
  
  Med Sci Monit 11-3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation2005
- Author(s)
  S.Kanaji, T.Kanaji, B.Jacquelin, M.Chang, D.J.Nugent, N.Komatsu, M.Moroi, K.Izuhara, T.J.Kunicki.
- Journal Title
  
  Blood 105-10
  
  Pages: 3888-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment.2005
- Author(s)
  T.Toki, F.Katsuoka, R.Kanezaki, G.Xu, H.Kurotaki, J.Sun, T.Kamio, S.Watanabe, S.Tandai, K.Terui, S.Yagihashi, N.Komatsu, K.Igarashi, M.Yamamoto, E.Ito.
- Journal Title
  
  Blood 105-8
  
  Pages: 3100-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591005
[Journal Article] Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in MPN cells
- Author(s)
  Mitumori T, Nozaki Y, Yamamoto T, Kawashima I, Shobu Y, Nakajima K, Komatsu N, Kirito K
- Journal Title
  
  Exp Hematol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591407
[Patent] 非公開2019
- Inventor(s)
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Holder
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-036119
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K09859
[Patent] 骨髄増殖性腫瘍の診断2018
- Inventor(s)
  森下総司，小松則夫，山脇紗耶，常田聡，川路英哉，伊藤昌可
- Industrial Property Rights Holder
  森下総司，小松則夫，山脇紗耶，常田聡，川路英哉，伊藤昌可
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-078074
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15K15368
[Patent] 骨髄増殖性腫瘍の診断2018
- Inventor(s)
  森下総司, 小松則夫, 他
- Industrial Property Rights Holder
  森下総司, 小松則夫, 他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-078074
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H04211
[Patent] リンパ節腫脹病変の評価方法2014
- Inventor(s)
  森下総司、荒木真理人、小松則夫
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-003192
- Acquisition Date
  2014-01-10
- Overseas
- Data Source
  KAKENHI-PROJECT-23591407
[Patent] 急性白血病における分化誘導薬の診断薬2013
- Inventor(s)
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Holder
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-212611
- Filing Date
  2013-10-10
- Data Source
  KAKENHI-PUBLICLY-25118725
[Patent] 急性白血病における分化誘導薬の診断薬2013
- Inventor(s)
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-212611
- Acquisition Date
  2013-10-10
- Overseas
- Data Source
  KAKENHI-PROJECT-23591407
[Patent] JAK2変異遺伝子の検出方法2013
- Inventor(s)
  森下総司,小松則夫
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-207818
- Acquisition Date
  2013-10-03
- Overseas
- Data Source
  KAKENHI-PROJECT-23591407
[Patent] 急性前骨髄性白血病治療薬のスクリーニング方法2012
- Inventor(s)
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Holder
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-181369
- Filing Date
  2012-08-20
- Data Source
  KAKENHI-PUBLICLY-23118528
[Patent] 急性前骨髄球性白血病治療薬のスクリーニング方法2012
- Inventor(s)
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-181369
- Filing Date
  2012-08-20
- Overseas
- Data Source
  KAKENHI-PROJECT-23591407
[Patent] JAK2遺伝子の変異解析法2010
- Inventor(s)
  野田尚宏,関口勇地,森下総司,常田聡,小松則夫,蓮沼彩,桐戸敬太
- Industrial Property Rights Holder
  独立行政法人産業技術総合研究所・早稲田大学・順天堂大学
- Industrial Property Rights Type
  特許
- Patent Publication Number
  2012-034580
- Acquisition Date
  2010-08-03
- Overseas
- Data Source
  KAKENHI-PROJECT-23591407
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin.2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  23rd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Copy number of JAK2V617 modulates human hematopoietic cell differentiation .2018
- Author(s)
  Edahiro Y, Mano S, Takei H, Li L, Morishita S, Gotoh A, Tsuneta S, Osaka A, Araki M, Komatsu N
- Organizer
  8th International Conference on Myeloproliferative Neoplasms
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06690
[Presentation] トリプルネガティブ本態性血小板血症症例の臨床像と遺伝子変異.2018
- Author(s)
  稲野資明, 荒木真理人, 福田泰隆, 森下総司, 落合友則, 三澤恭平, 伊藤雅文, 山本紘司, 楊印杰, 田口鉄平, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 変異型CALRの多量体化はMPLとの結合と活性化に必須である2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Interferon therapy for pregnant patients with myeloproliferative neoplasms.2018
- Author(s)
  Edahiro Y, Gotoh A, Ando J, Tsutsui M, Morishita S, Osaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06690
[Presentation] Clinical and molecular features of patients with triple-negative essential thrombocythemia.2018
- Author(s)
  Inano T, Araki M, Fukuda Y, Morishita S, Ochiai T, Misawa K, Ito M, Yamamoto K, Yang Y, Taguchi T, Edahiro Y, Imai M, Gotoh A, Osaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] The Zygosity of JAK2V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis2018
- Author(s)
  Takei H, Edahiro Y, Li L, Mizukami Y, Imai M, Morishita S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  60th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] The Zygosity of JAK2V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis.2018
- Author(s)
  Takei H, Edahiro Y, Li L, Mizukami Y, Imai M, Morishita S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  ASH 60th Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] APL細胞の分化誘導におけるATRA標的遺伝子の同定.2018
- Author(s)
  角南義孝, 荒木真理人, 山本誠司, 堀内祥行, 辻岡一也, 薫茂, 今井美沙, 森下総司, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Introduction of CALR and JAK2 V617F mutations to UT-7/Epo and K562 by the CRISPR/Cas9 system.2018
- Author(s)
  Yasuda S, Aoyama S, Watanabe D, Araki M, Komatsu N, Miura O, Kawamata N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 細胞減少療法はPMF患者における腎機能の悪化を防止する.2018
- Author(s)
  福田泰隆, 荒木真理人, 山本紘司, 森下総司, 稲野資明, 三澤恭平, 落合友則, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] SLAMF7high CD16negative Monocytes Increase in Peripheral Blood of Patients with Myelofibrosis in Correlation with JAK2V617F Mutation2018
- Author(s)
  Maekawa T, Kato S, Okada Y, Tachi N, Teramoto M, Kawamura T, Osawa Y, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita S, Araki M, Komatsu N, Kimura F.
- Organizer
  60th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] JAK2V617F変異アレル数はヒト血球分化を変化させる.2018
- Author(s)
  竹井拓, 枝廣陽子, 李麗華, 水上喜久, 森下総司, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 変異型 CALRの多量体化は MPLとの結合と活性化に必須である.2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  23rd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] トリプルネガティブ本態性血小板血症症例の臨床像と遺伝子変異.2018
- Author(s)
  稲野資明, 荒木真理人, 福田泰隆, 森下総司, 落合友則, 三澤恭平, 伊藤雅文, 山本紘司, 楊印杰, 田口鉄平, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] UT-7/EpoおよびK562に対するCRISPR/Cas9法を用いたCALRおよびJAK2V617F変異の導入.2018
- Author(s)
  安田峻一郎, 青山慧, 渡邊大介, 荒木真理人, 小松則夫, 三浦修, 川又紀彦.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Cytoreductive therapy prevents worsening go renal function in patients with primary myelofibrosis.2018
- Author(s)
  Fukuda Y, Araki M, Imamoto K, Morishita S, Inano T, Misawa K, Ochiai T, Edahiro Y, Imai M, Gotoh A, Osaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06690
[Presentation] Interferon therapy for pregnant patients with myeloproliferative neoplasms.2018
- Author(s)
  Edahiro Y, Gotoh A, Ando J, Tsutsui M, Morishita S, Osaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] 受容体活性化において野生型JAK2は変異型JAK2を抑制しているようである.2018
- Author(s)
  北澤爽汰, 荒木真理人, 森下総司, 楊印杰, 今井美沙, 大坂顕通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 変異型 CALRの多量体化は MPLとの結合と活性化に必須である.2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin.2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  23rd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] ターゲット遺伝子シーケンスパネルによる原発性骨髄線維症の遺伝子変異解析.2018
- Author(s)
  森下総司, 落合友則, 三澤恭平, 稲野資明, 橳島麻衣, 大坂顕道, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Copy number of JAK2V617F modulates human hematopoietic cell differentiation2018
- Author(s)
  Edahiro Y, Mano S, Takei H, Morishita S, Tsuneda S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  8th International Conference on Myeloproliferative Neoplasms
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Clinical and molecular features of patients with triple-negative essential thrombocythemia.2018
- Author(s)
  Inano T, Araki M, Fukuda Y, Morishita S, Ochiai T, Misawa K, Ito M, Yamamoto K, Yang Y, Taguchi T, Edahiro Y, Imai M, Gotoh A, Osaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06690
[Presentation] JAK2V617F変異アレル数はヒト血球分化を変化させる.2018
- Author(s)
  竹井拓, 枝廣陽子, 李麗華, 水上喜久, 森下総司, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 細胞減少療法はPMF患者における腎機能の悪化を防止する.2018
- Author(s)
  福田泰隆, 荒木真理人, 山本紘司, 森下総司, 稲野資明, 三澤恭平, 落合友則, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 変異型分子シャペロンによるサイトカイン受容体活性化の分子メカニズム2018
- Author(s)
  荒木真理人, 小松則夫
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] トリプルネガティブ本態性血小板血症症例の臨床像と遺伝子変異.2018
- Author(s)
  稲野資明, 荒木真理人, 福田泰隆, 森下総司, 落合友則, 三澤恭平, 伊藤雅文, 山本紘司, 楊印杰, 田口鉄平, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08372
[Presentation] Wild-type JAK2 may suppress mutant JAK2 activity in cytokine receptor activation.2018
- Author(s)
  Kitazawa S, Araki M, Morishita S, Yang Y, Imai M, Ohsaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 骨髄線維化を伴う骨髄異形成症候群の臨床病態および分子発症機序の解明.2018
- Author(s)
  新谷直樹, 原田浩徳, 原田結花, 飯塚弘子, 森下総司, 荒木真理人, 大坂顯通, 土岐典子, 大橋一輝, 萩原政夫, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Cytoreductive therapy prevents worsening of renal function in patients with primary myelofibrosis.2018
- Author(s)
  Fukuda Y, Araki M, Imamoto K, Morishita S, Inano T, Misawa K, Ochiai T, Edahiro Y, Imai M, Gotoh A, Osaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Copy number of JAK2V617 modulates human hematopoietic cell differentiation .2018
- Author(s)
  Edahiro Y, Mano S, Takei H, Li L, Morishita S, Gotoh A, Tsuneta S, Osaka A, Araki M, Komatsu N
- Organizer
  8th International Conference on Myeloproliferative Neoplasms
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Copy number of JAK2V617F modulates human hematopoietic cell differentiation.2018
- Author(s)
  Edahiro Y, Mano S, Takei H, Li L, Morishita S, Gotoh A, Tsuneda S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  8th International Conference on Myeloproliferative Neoplasms
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation.2017
- Author(s)
  Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Mizukami Y, Hironaka Y, Takei H, Morishita S, Kihara Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] カルレチキュリン変異を有する血球前駆細胞は巨核球への分化偏向性を有する.2017
- Author(s)
  竹井拓, 眞野修一, 増渕菜弥, 水上喜久, 今井美沙, 森下総司, 枝廣陽子, 弘中由美, 橳島麻衣, 常田聡, 遠藤大, 中村壮, 江藤浩之, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation.2017
- Author(s)
  Nami Masubuchi, Marito Araki, Erina Hayashi, Yinjie Yang, Misa Imai, Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihiko Kihara, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 家族性骨髄増殖性腫瘍患者からの iPS 細胞株の樹立.2017
- Author(s)
  眞野修一, 竹井拓, 森下総司, 水上喜久, 増渕菜弥, 弘中由美, 橳島麻衣 ,常田聡, 大坂顯通, 荒木真理人, 小松則夫
- Organizer
  第 79 回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 骨髄増殖性腫瘍に見出される変異型 CALR 蛋白質の細胞内局在.2017
- Author(s)
  林英里奈, 荒木真理人, 増渕菜弥, 水上喜久, 楊印杰, 今井美沙, 弘中由美, 竹井拓, 木原慶彦, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Mechanisms governing the accumulation of mutant calreticulin2017
- Author(s)
  Yoshihiko Kihara, Marito Araki, Yinjie Yang, Misa Imai, Nami Masubuchi, Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 変異型 CALR による巨核球分化偏向性は GATA2 の発現亢進と相関している.2017
- Author(s)
  竹井拓, 眞野修一, 増渕菜弥, 水上喜久, 今井美沙, 森下総司, 枝廣陽子, 弘中由美, 橳島麻衣, 遠藤大, 中村壮, 江藤浩之, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第79回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Localization of mutant calreticulin in the Golgi apparatus is required for its oncogenic capacity2017
- Author(s)
  Nami Masubuchi, Marito Araki, Erina Hayashi, Yinjie Yang, Misa Imai Yoshihiko Kihara, Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  59th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells2017
- Author(s)
  Hiraku Takei, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Soji Morishita, Misa Imai, Yoko Edahiro, Yumi Hironaka, Mai Nudejima, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Organizer
  22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] BCR-JAK2 陽性骨髄増殖性腫瘍.2017
- Author(s)
  筒井深雪, 後藤明彦, 森下総司, 荒木真理人, 福田泰隆, 新田英昭, 安藤純, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Skewed megakaryopoiesis by mutant calreticulin is associated with increased GATA2 expression2017
- Author(s)
  Hiraku Takei, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Yoko Edahiro Yumi Hironaka Mai Nudejima Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Skewed megakaryopoiesis observed in hematopoietic progenitor cells harboring calreticulin mutation.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 変異型 CALR タンパク質の発現を制御するメカニズム.2017
- Author(s)
  木原慶彦, 荒木真理人, 楊印杰, 今井美沙, 増渕菜弥, 水上喜久, 弘中由美, 竹井拓, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Skewed megakaryopoiesis by mutant calreticulin is associated with increased GATA2 expression.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Myeloproliferative neoplasm with BCR-JAK2 fusion2017
- Author(s)
  Tsutsui M, Gotoh , Morishita S, Araki M, Fukuda Y, Nitta H, Ando J, Komatsu N.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] iPS 細胞由来若返りCTL 治療のためのCD8b の役割.2017
- Author(s)
  崎山祐未, 安藤美樹, 村越勇人, 安藤純, 大坂顯通, 小松則夫, 滝口雅文, 中内啓光.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Mutant Calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms.2017
- Author(s)
  Marito Araki, Yinjie Yang, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Erina Hayashi, Yumi Hironaka, Soji Morishita, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  The annual GAP Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 変異型CALRの細胞内コンパートメントへの局在がトロンボポエチン受容体の活性化に必要である2017
- Author(s)
  荒木真理人, 小松則夫
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity.2017
- Author(s)
  Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Takei H, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  59th Annual Meeting of the American Society of Hematology and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 家族性骨髄増殖性腫瘍患者からの iPS細胞株の樹立.2017
- Author(s)
  眞野修一, 竹井拓, 森下総司, 水上喜久, 増渕菜弥, 弘中由美, 橳島麻衣, 常田聡, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] マウス胎仔における造血幹細胞依存性および非依存性の血球系譜の発生起源.2017
- Author(s)
  横溝智雅, 渡邊直紀, 森誠一, 髙久智生, 大里元美, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N
- Organizer
  22nd Congress European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Clinical Performance Study of a novel JAK2V617F mutation quantitative kits for patients with Ph-MPN.2017
- Author(s)
  野口雅章, 小松則夫, 小池道明, 木崎昌弘, 片山直之, 土橋史明, 薄井紀子, 桐戸敬太.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 骨髄増殖性腫瘍に見出される変異型 CALR 蛋白質の細胞内局在2017
- Author(s)
  林英里奈, 荒木真理人, 増渕菜弥, 水上喜久, 楊印杰, 今井美沙 , 弘中由美, 竹井拓, 木原慶彦, 枝廣陽子, 大坂顯通, 小松則夫
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 変異型CALRの細胞内コンパートメントへの局在がトロンボポエチン受容体の活性化に必要である.2017
- Author(s)
  Araki M, Komatsu N.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation2017
- Author(s)
  Nami Masubuchi, Marito Araki, Erina Hayashi, Yinjie Yang, Misa Imai Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihiko Kihara, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 骨髄増殖性腫瘍細胞において変異型Calreticulinはトロンボポエチン受容体と相互作用しJAK2を活性化する2016
- Author(s)
  荒木真理人, 小松則夫
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis2016
- Author(s)
  Kirito K, Okamoto S, Shishi K, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Ogitani K, Komatsu N, Okada H, Amagasaki T, Suzuki K Yonezo T, Akashi K
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Mutant calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] 骨髄増殖生腫瘍を引き起こす変異型Calreticulinの細胞内局在2016
- Author(s)
  増渕菜弥, 荒木真理人, Yinjie Yang, 弘中由美, 竹井拓, 森下総司, 今井美沙, 水上喜久, Kan Shin、大坂顯通, 小松則夫.
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Mutant Calreticulin activates JAK2 by an interaction with thrombopoietin receptor in myeloproliferative neoplasm cells.2016
- Author(s)
  Araki M, Komatsu N.
- Organizer
  第75回日本癌学会学術総会.
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N
- Organizer
  21st Congress European hematology association
- Place of Presentation
  Copenhagen
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Cell surface localization of mutant Calreticulin that induces myeloproliferative neoplasms (MPNs).2016
- Author(s)
  Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Mutant calreticulin activate the thrombopoietin receptor in myeloproliferative neoplasm2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Impact of mutations on efficacy of anagrelide in Japanese patients with essential thrombocythemia2016
- Author(s)
  Tsutsui M, Gotoh, A Araki M, Morishita S, Komatsu N
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Mutant Calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms.2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms.2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
- Organizer
  21st Congress of the European Hematology Association.
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Differential clinical features by subtypes of Calreticulin mutation in myeloproliferative neoplasms2016
- Author(s)
  Misawa K, Araki M, Ochiai T, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Sunami S, Gotoh A, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Modeling MPN phenotypes in vitro by using iPSC harboring CALR ins5 mutation2016
- Author(s)
  Takei T, Masubuchi N, Mano S, Araki M, Morishita S, Mizukami Y, Kan S, Edahiro Y, Sunami Y, Hironaka Y, Endo H, Nakamura S, Eto K, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Modeling MPN phenotypes in vitro by using iPSC harboring CALR ins5 mutation.2016
- Author(s)
  Takei H, Masubuchi N, Mano S, Araki M, Morishita S, Mizukami Y, Kan S, Edahiro Y, Sunami Y, Hironaka Y, Endo H, Nakamura S, Eto K, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms (MONs)2016
- Author(s)
  Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms (MPNs)2016
- Author(s)
  Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Ohsaka A, Komatsu N
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Clinical characteristics of BCSH criteria defined PV and ET patients in Japan2016
- Author(s)
  Ochiai M, Araki M, Misawa K, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Sunami Y, Goth A, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Modeling MPN phenotypes in vitro by using iPSC harboring CALR ins5 mutation,2016
- Author(s)
  Takei H, Masubuchi N, Mano S, Araki M, Morishita S, Mizukami Y, Kan S, Edahiro Y, Sunami Y, Hironaka Y, Endo H, Nakamura S, Eto K, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] ビノレルビンは乳癌細胞株においてアグリソーム形成を阻害することによりボルテゾミブ誘導性の細胞毒性を増強する2016
- Author(s)
  宮原か奈, 森谷昇太, 小松誠一郎, 平澤一浩, 阿部晃久, 平本正樹, 石川孝, 宮澤啓介
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] 骨髄増殖生腫瘍を引き起こす変異型Calreticulinの細胞内局在.2016
- Author(s)
  増渕菜弥、荒木真理人、楊印杰、弘中由美、竹井拓、森下総司、今井美沙、水上喜久、カンシン、大坂顯通、小松則夫
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] A highly specific method for detecting a single copy JAK2V617F mutation2015
- Author(s)
  森下総司, 荒木真理人, 弘中由美, 角南義孝, 枝廣陽子, 筒井深雪, 大坂顯通, 小松則夫
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム（石川県、金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Establishment of iPS cells from myeloproliferative neoplasms patients with CALR mutation2015
- Author(s)
  竹井拓, 森下総司, 荒木真理人, 水上喜久, 枝廣陽子, 角南義孝, 弘中由美, 津村真知子, 常田聡, 遠藤大, 中村壮, 江藤浩之, 大坂顯通, 小松則夫
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム（石川県、金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Assessing the Safety and Efficacy of Ruxolitinib in a Multicenter, Open-Label, Expanded-Access Study in Japanese Patients with Myelofibrosis (MF)2015
- Author(s)
  Keita Kirito, Norio Komatsu, Kazuya Shimoda, Hikaru Okada, Taro Amagasaki, Toshio Yonezu, Koichi Akashi
- Organizer
  第57回米国血液学会議
- Place of Presentation
  Orland,Florida, USA
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] A interim analysis of stop trial against CMP-CP in CMR patients who had received sequential TKIs2015
- Author(s)
  佐藤恵理子，森下総司，野口雅章，小池道明，大津洋，小松則夫
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県，金沢市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25460699
[Presentation] Activation of AP-1 By JAK2V617F through Induction and Stabilization of c-FOS2015
- Author(s)
  Yoko Edahiro, Marito Araki, Yumi Hironaka, Yinjie Yang, Soji Morishita, Yoshitaka Sunami, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第57回米国血液学会議
- Place of Presentation
  Orland,Florida, USA
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Early disease onset of patients with triple-negative myeloproliferative neoplasms2015
- Author(s)
  白根脩一, 荒木真理人, 森下総司, 枝廣陽子, 竹井拓, 津村真知子, 弘中由美, 落合友則, 三澤恭平, 大坂顯通, 小松則夫
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム（石川県、金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Management of adult chronic immune thrombocytopenia in JAPAN : Patient and hematologist perspective2013
- Author(s)
  Tsukune Y, Edahiro Y, Komatsu N
- Organizer
  The 18th Congress of the European Hematology Association
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-23591407
[Presentation] Identification of FOXO3A as a key downstream target for the oncogenic JAK2V617F2013
- Author(s)
  Kobayashi M, Araki M, Hironaka Y, Ohsaka A, Komatsu N
- Organizer
  55th Annual Meeting of the American Society of Hematology
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23591407
[Presentation] The Sirtuin inhibitor induces APL cell differentiation2012
- Author(s)
  Sunami Y, Araki M,Morishita S,Hironaka Y,Edahiro Y,Ohsaka A,Komatsu N
- Organizer
  The 3rd JSH International Symposium 2012
- Place of Presentation
  Kawagoe, Japan
- Data Source
  KAKENHI-PROJECT-23591407
[Presentation] Rituximab Activation of AKTand Pathways Is Dependent on Membrane Lipid Raft Cholesterol Levels in Lymphoma Cells2011
- Author(s)
  Nozaki Y, Mitsumori T, Komatsu N, Kirito K
- Organizer
  第53回米国血液学会
- Place of Presentation
  SanDiego
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] Lipid RaftはリツキシマブによるHIF-1活性化を規定する2011
- Author(s)
  野崎由美、Qiao Qiao、迫江公己、小松則夫、桐戸敬太
- Organizer
  第8回がんとハイポキシア研究会
- Place of Presentation
  札幌市
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] Hypoxia Blocks Activation of JAK2V617F Through Suppression of SHP-2 Expression in MPN cells2011
- Author(s)
  Mitsumori T, Nozaki Y, Komatsu N, Kirito K
- Organizer
  第53回米国血液学会
- Place of Presentation
  SanDiego
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 真性赤血球増加症における血栓症のリスク解析2011
- Author(s)
  山本健夫、三森徹、川島一郎、濱中聡至、野崎由美、中嶌圭、小松則夫、桐戸敬太
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] MPN細胞において、低酸素状態はSHP-2誘導を介しJAK2V617Fの活性化を阻害する2011
- Author(s)
  三森徹、野崎由美、川島一郎、山本健夫、濱中聡至、中嶌圭、小松則夫、桐戸敬太
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] The membrane cholesterollevels of B cell lymphoma cells determine rituximab-induced AKT activation2011
- Author(s)
  Nozaki Y, Mitsumori T, Komatsu N, Kirito K
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] The SirT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells2011
- Author(s)
  角南義孝、小松則夫, 他
- Organizer
  53回米国血液学会(53rd.ASH annual meeting)
- Place of Presentation
  サンディェゴ
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PUBLICLY-23118528
[Presentation] リツキシマブによるHIF-1活性化にはLipid Raftが関与する2010
- Author(s)
  野崎由美、Qiao Qiao、迫江公己、小松則夫、桐戸敬太
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 治療難治性であったTリンパ芽球性リンパ腫の一例2010
- Author(s)
  雨宮憲彦,小岩井孝夫,風間文智,畑山一貴,遠藤武,高野勝弘,三森徹,桐戸敬太,小松則夫,尾崎由基男
- Organizer
  第11回日本検査血液学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 低酸素によるJAK2V617F活性制御2010
- Author(s)
  三森徹、野崎由美、小松則夫、桐戸敬太
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] 膵癌が疑われた膵臓原発の髄外性形質細胞腫の1例2010
- Author(s)
  沼田裕樹,小佐野雅識,川島一郎,中嶌圭,野崎由美,山本健夫,三森徹,小松則夫,桐戸敬太
- Organizer
  第573回日本内科学会関東地方会例会
- Place of Presentation
  東京都
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] リツキシマブはHIF-1を介して抗アポトーシス蛋白Survivinを誘導する2009
- Author(s)
  野崎由美,桐戸敬太, QiaoQiao,迫江公己,小松則夫
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都府
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] たこつぼ型心筋症を発症した多発性骨髄腫2009
- Author(s)
  三森徹,中嶌圭,野崎由美,濱中聡至,永嶋貴博,岩尾憲明,桐戸敬太,小松則夫
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都府
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591197
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-12008
- Author(s)
  Keita Kirito, Kozue Yoshida, Yongzhen Hu, Qiao Qiao, Kumi Sakoe, and Norio Komatsu
- Organizer
  第50回米国血液学会
- Place of Presentation
  San Francisco
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-18390282
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-12008
- Author(s)
  Kirito, K., Yoshida, K., Yongzhen H., Qiao Q., Sakoe, K., Komatsu, N.
- Organizer
  50 th Annual Meeting of American Society of Hematology
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-19591103
[Presentation] HIF-1 Prevents Hematopoietic Cells from Cell Damage by Overproduction of Mitochondrial ROS after Cytokine Stimulation through Induction of PDK-12008
- Author(s)
  1.Kirito K, Yoshida K, Hu Y, Qiao Q, Sakoe K, Komatsu N.
- Organizer
  第50回米国血液学会
- Place of Presentation
  San Fransico
- Year and Date
  2008-12-07
- Data Source
  KAKENHI-PROJECT-19591103
[Presentation] HIF-1 Supports the Survival of Multiple Myeloma Cells through the Induction of Survivin Gene2007
- Author(s)
  Kirito, K. Yongzhen, Hu., Yoshida, K., Mitsumori, T., Nakajima, K., Nozaki, Y., Nagashima, T., Kunitamae, M., Sakoe, K., Komatsu, N.
- Organizer
  49th Annual Meeting of American Society of Hematology
- Place of Presentation
  Atlanta, GA, USA
- Year and Date
  2007-12-09
- Data Source
  KAKENHI-PROJECT-19591103
[Presentation] Histone acetyltransferase PCAF is required for ATRA-induced granulocytic differentiation in acute promyelocytic leukemia cells.
- Author(s)
  Yoshitaka Sunami, Marito Araki, Akihiro Ito, Yumi Hironaka, Akimichi Ohsaka, Minoru Yoshida, Norio Komatsu
- Organizer
  American Society of Hematology 56th Annual Meeting
- Place of Presentation
  San Francisco, US
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PUBLICLY-25118725
[Presentation] Histone acetyltransferase PCAF is required for ATRA-induced granulocytic differentiation in APL cells.
- Author(s)
  Yoshitaka Sunami, Marito Araki, Akihiro Ito, Yumi Hironaka, Akimichi Ohsaka, Minoru Yoshida, Norio Komatsu
- Organizer
  International Society of Hematology 35th World Congress 2014
- Place of Presentation
  Beijing, China
- Year and Date
  2014-09-04 – 2014-09-07
- Data Source
  KAKENHI-PUBLICLY-25118725
[Presentation] ATRA induces APL cell granulocytic differentiation through the PCAF overexpression.
- Author(s)
  Yoshitaka Sunami, Marito Araki, Akihiro Ito, Yumi Hironaka, Akimichi Ohsaka, Minoru Yoshida, Norio Komatsu
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PUBLICLY-25118725

1. KIRITO Keita (90306150)

# of Collaborated Projects: 13 results

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2. UCHIDA Mie (80316520)

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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. ITO akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
52. KUROSAKI Hajime

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. BABA Tomohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. SAITO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. CHE Xiao-fang

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. SUZUKI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. SHIDE Kotaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. UEDA Koki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. OGAWA Kazuei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. HIROSHI Kimura

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 平尾敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
62. 角南義孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
63. 平本正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
64. 森谷昇太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
65. 平澤一浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
66. 枝廣陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
67. 織谷健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
68. 下田和哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
69. 下妻晃二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
70. 東守洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
71. 田丸淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
72. 小松誠一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
73. 宮園浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
74. 池田和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
75. 青山和正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
76. 伊藤嘉規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOMATSU Norio 小松 則夫

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本態性血小板血症に特異的な転写ネットワークによる細胞腫瘍化メカニズムの解明Principal InvestigatorOngoing

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変異型CALRのホモ多量体化を標的とした治療概念の確立Ongoing

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ERストレスを介した新規骨髄線維症腫瘍クローン廃絶法の開発Ongoing

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CALR遺伝子変異により発症する骨髄増殖性腫瘍に対する新規治療戦略の開発Ongoing

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本態性血小板血症の遺伝子情報に基づく個別化治療の実現Ongoing

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家族内発症例の遺伝的要因の同定を基盤とした骨髄増殖性腫瘍発症機序の解明Principal InvestigatorOngoing

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Identification of promising marker(s) for essential thrombocythemia diagnosis by differential gene expression approachPrincipal Investigator

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Sirtuin阻害による急性前骨髄球性白血病細胞の分化誘導Principal Investigator

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ＡＴＲＡによるＡＰＬ細胞の分化誘導の分子メカニズムPrincipal Investigator

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KOMATSU Norio 小松則夫