MIZUKAMI Yoshihisa 水上喜久

Researcher Number	30756698
Affiliation (based on the past Project Information) *help	2021 – 2022: 聖マリアンナ医科大学, 医学部, 助教 2016 – 2019: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 骨髄増殖性腫瘍 / メトホルミン / リーリン / ミクログリア / ニューロン新生 / 免疫細胞 / 細胞移植療法 / 認知症モデルマウス / アミロイドβ / アルツハイマー病 … More / TPO受容体 c-MPL / 分子シャペロン CALR / 骨髄増殖性腫瘍 MPN / 黄色蛍光タンパク質Venus / キメラタンパク質 / KDEL / サイトカイン受容体c-MPL / 分子シャペロンCALR / TPOR / ライブセルイメージング / CALR / 分子シャペロン / 疾患iPS細胞 / 原発性骨髄線維症 / 免疫不全マウス / 変異型CALR / 奇形腫 / カルレティキュリン / 造血幹細胞 / iPS細胞 / 本態性血小板血症 / 骨髄線維症 / ドライバー変異 / JAK2 / calreticulin Less

認知症の予防と根治を目指した細胞移植療法の開発Principal Investigator
- Principal Investigator
  
  水上喜久
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  St. Marianna University School of Medicine
Live imaging system to monitor mutant Calreticulin which promote myeroproliferative neoplasmsPrincipal Investigator
- Principal Investigator
  
  Mizukami Yoshihisa
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Establishment of in vitro model for essential thrombocythemia by mutant calreticulinPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Yoshihisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University

All 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.2021
- Author(s)
  Arimitsu N, Mizukami Y, Shimizu J, Takai K, Suzuki T, Suzuki N
- Journal Title
  
  Molecular and Cellular Neuroscience
  
  Volume: 112 Pages: 103614-103614
- DOI
  10.1016/j.mcn.2021.103614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09009, KAKENHI-PROJECT-21K07529, KAKENHI-PROJECT-21K12673
[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019
- Author(s)
  Masubuchi Nami、Araki Marito、Yang Yinjie、Hayashi Erina、Imai Misa、Edahiro Yoko、Hironaka Yumi、Mizukami Yoshihisa、Kihara Yoshihiko、Takei Hiraku、Nudejima Mai、Koike Masato、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 34 Issue: 2 Pages: 499-509
- DOI
  10.1038/s41375-019-0564-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126
[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018
- Author(s)
  Araki Marito、Yang Yinjie、Imai Misa、Mizukami Yoshihisa、Kihara Yoshihiko、Sunami Yoshitaka、Masubuchi Nami、Edahiro Yoko、Hironaka Yumi、Osaga Satoshi、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 1 Pages: 122-131
- DOI
  10.1038/s41375-018-0181-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16100, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Journal Article] Skewed megakaryopoiesis in human iPS cell-derived hematopoietic progenitor cells harboring calreticulin mutations2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19587
[Journal Article] Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihsa Mizukami, Misa Imai, Soji Morishita, Kyohei Misawa, Tomonori Ochiai, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中 Issue: 6 Pages: 791-802
- DOI
  10.1111/bjh.15266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11017, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-18H04164
[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定2019
- Author(s)
  水上喜久、荒木真理人、今井美沙、林絵里奈、増渕菜弥、楊印杰、木原慶彦、弘中由美、大坂顯通、小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定2019
- Author(s)
  水上喜久, 荒木真理人, 今井美沙, 林英里奈, 増渕菜弥, 楊印杰, 木原慶彦, 弘中由美, 大坂顯通, 小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] calreticulin変異による骨髄増殖性腫瘍発症の分子メカニズム2019
- Author(s)
  荒木真理人, 楊印杰, 増渕菜弥, 林英里奈, 水上喜久, 木原慶彦, 今井美沙, 弘中由美, 橳島麻衣, 枝廣陽子, 大坂顯通, 小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] Mutant specific sequence promotes accumulation of mutant CALR in the Golgi apparatus2019
- Author(s)
  Mizukami Y, Araki M, Imai M, Hayashi E, Masubuchi N, Yang Y, Kihara Y, Hironaka Y, Ohsaka A, Komatsu N.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] 変異型Calreticulin特異的配列によるゴルジ体への局在2019
- Author(s)
  水上喜久, 荒木真理人, 今井美沙, 林英里奈, 増渕菜弥, 楊印杰, 木原慶彦, 弘中由美, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] 分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化2019
- Author(s)
  増渕菜弥, 荒木真理人, 木原慶彦, 楊印杰, 今井美沙, 水上喜久, 林英里奈, 弘中由美, 竹井拓, 枝廣陽子, 大坂顯通, 小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] 分子シャペロンの異常により生じる細胞腫瘍化の分子メカニズム2019
- Author(s)
  荒木真理人, 楊印杰, 増渕菜弥, 水上喜久, 木原慶彦, 今井美沙, 枝廣陽子, 大坂顯通, 小松則夫
- Organizer
  第15回血液学若手研究者勉強会(麒麟塾)
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] The Zygosity of JAK2V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis.2018
- Author(s)
  Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  第60回米国血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] JAK2V617F変異アレル数はヒト血球分化を変化させる2018
- Author(s)
  Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16126
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N
- Organizer
  22nd Congress European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Skewed megakaryopoiesis by mutant calreticulin is associated with increased GATA2 expression.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 家族性骨髄増殖性腫瘍患者からの iPS 細胞株の樹立.2017
- Author(s)
  眞野修一, 竹井拓, 森下総司, 水上喜久, 増渕菜弥, 弘中由美, 橳島麻衣 ,常田聡, 大坂顯通, 荒木真理人, 小松則夫
- Organizer
  第 79 回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Skewed megakaryopoiesis observed in hematopoietic progenitor cells harboring calreticulin mutation.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation.2017
- Author(s)
  Nami Masubuchi, Marito Araki, Erina Hayashi, Yinjie Yang, Misa Imai, Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihiko Kihara, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms (MPNs)2016
- Author(s)
  Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Ohsaka A, Komatsu N
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Modeling MPN phenotypes in vitro by using iPSC harboring CALR ins5 mutation,2016
- Author(s)
  Takei H, Masubuchi N, Mano S, Araki M, Morishita S, Mizukami Y, Kan S, Edahiro Y, Sunami Y, Hironaka Y, Endo H, Nakamura S, Eto K, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 骨髄増殖生腫瘍を引き起こす変異型Calreticulinの細胞内局在.2016
- Author(s)
  増渕菜弥、荒木真理人、楊印杰、弘中由美、竹井拓、森下総司、今井美沙、水上喜久、カンシン、大坂顯通、小松則夫
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N
- Organizer
  21st Congress European hematology association
- Place of Presentation
  Copenhagen
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Mutant calreticulin activate the thrombopoietin receptor in myeloproliferative neoplasm2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587

1. Komatsu Norio (50186798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. Araki Marito (80613843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. 鈴木登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高井憲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUKAMI Yoshihisa 水上 喜久

Research Projects

Research Products

Co-Researchers

認知症の予防と根治を目指した細胞移植療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Live imaging system to monitor mutant Calreticulin which promote myeroproliferative neoplasmsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of in vitro model for essential thrombocythemia by mutant calreticulinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Skewed megakaryopoiesis in human iPS cell-derived hematopoietic progenitor cells harboring calreticulin mutations2018

Author(s)

Journal Title

Data Source

[Journal Article] Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定2019

Author(s)

Organizer

Data Source

[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定2019

Author(s)

Organizer

Data Source

[Presentation] calreticulin変異による骨髄増殖性腫瘍発症の分子メカニズム2019

Author(s)

Organizer

Data Source

[Presentation] Mutant specific sequence promotes accumulation of mutant CALR in the Golgi apparatus2019

Author(s)

Organizer

Data Source

[Presentation] 変異型Calreticulin特異的配列によるゴルジ体への局在2019

Author(s)

Organizer

Data Source

[Presentation] 分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化2019

Author(s)

Organizer

Data Source

[Presentation] 分子シャペロンの異常により生じる細胞腫瘍化の分子メカニズム2019

Author(s)

Organizer

Data Source

[Presentation] The Zygosity of JAK2V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis.2018

Author(s)

Organizer

Data Source

[Presentation] JAK2V617F変異アレル数はヒト血球分化を変化させる2018

Author(s)

MIZUKAMI Yoshihisa 水上喜久