Hatake Kiyohiko 畠清彦

… Alternative Names

HATAKE Kitohiko 畠清彦

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Researcher Number	80192699
Affiliation (Current)	2025: 国際医療福祉大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2010: Japanese Foundation For Cancer Research, 癌化学療法センター臨床部, 部長 2009: Japanese Foundation For Cancer Research, 癌化学療法センター臨床部, 部長 2008: Japanese Foundation For Cancer Research, 癌化学療法センター・臨床部, 部長 2007: Japanese Foundation For Cancer Research, 癌化学療法センター臨床部, 部長 2005 – 2006: (財)癌研究会, 癌化学療法センター臨床部, 部長 … More 2003 – 2004: (財)癌研究会, 癌化学療法センター・臨床部, 部長 2001 – 2002: 財団法人癌研究会, 癌化学療法センター・臨床部, 部長 2000: Japanese Foundation for Cancer Research, Div. of Clinical Chemotherapy, Cancer Chemotherapy Center. Cancer Institute. Associate Chief, 癌化学療法センター・臨床部, 副部長 1994 – 1999: Jichi Medical School, Associate Professor, 医学部, 助教授 1990 – 1993: 自治医科大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences Except Principal Investigator Hematology / Cerebral neurosurgery
Keywords	Principal Investigator アポトーシス / シグナル伝達 / 細胞死 / FAP-1 / 薬剤反応性 / 癌 / 化学療法 / 抗癌剤 / 抗腫瘍効果 / 白血病 … More / インターロイキン8 / 内皮細胞 / purging tumor cells / aminopeptidase N / endothelial IL-8 / apoptosis / 腫瘍細胞除去 / アミノペプチダーゼ / 内皮細胞由来インターロイキン8 / T cell leukemia / endothelial cell derived interleukin-8 / Apoptosis / HIV / Fas / Fasリガンド / T細胞性白血病 / 共焦点顕微鏡 / 耐性 / 抗体療法 / 薬剤耐性 / 耐性克服 / 抗体医薬 / 内皮型IL-8 / SLAP(Src-like adaptor protein) / retinoic acid / 分化誘導 … More Except Principal Investigator 造血因子 / 造血幹細胞 / ex vivo / apoptosis / hemopoietic stem cell disorders / erythropoietin receptor / megakaryocytic cell line / hemopoietic factor / hemopoietic stem cell / CD34 / gene therapy / human being / experimenta model imitating / SCID mouse / malignant glioma / IL-12 gene / IL-12 / 遺伝子療法 / ヒト疑似環境モデル / SCIDマウス / 悪性グリオーマ細胞 / IL-12遺伝子 / transcription factor / erythropoietin gene / 赤白血病 / GATA-1 / アポトーシス / STAT転写因子群 / 赤芽球分化 / 巨核球株細胞 / シグナル伝達 / 受容体 / tyrosine phosphorylation / receptor / チロシンフォスファターゼ / アポトーシスと造血 / 幹細胞異常血液疾患 / エリスロポエチン受容体 / チロシン燐酸化 / 巨核球細胞株 / 造血因子受容体 / anti-leukemic cell antibody / spleen colony / mucopolysaccharide / c-kit / monoclonal antibody / hemopoietic growth factors / hemopoietic stem cells / 破骨細胞 / DIF / CD33 / WGA / cーkit / 抗白血病細胞抗体 / 脾コロニ- / ムコ多糖 / Cーkit / モノクロ-ナル抗体 Less

Analysis of resistance mechanism of cell death in chemotherapy and monoclonal antibody therapyPrincipal Investigator
- Principal Investigator
  
  HATAKE Kitohiko
- Project Period (FY)
  2005 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
化学療法と抗体療法における細胞死の耐性機序の解析Principal Investigator
- Principal Investigator
  
  畠清彦
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
内皮細胞との相互作用によるがん細胞のアポトーシス誘導機序の解析Principal Investigator
- Principal Investigator
  
  畠清彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Jichi Medical University
Development of treatment strategies for malignancies using novel apoptosis-inducing factors.Principal Investigator
- Principal Investigator
  
  HATAKE Kiyohiko
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Hematology
- Research Institution
  Japanese Foundation for Cancer Research
  Jichi Medical University
白血病細胞の分化により発現する新規SLAPと分化制御の解析Principal Investigator
- Principal Investigator
  
  畠清彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
Analysis of FAP-1 gene undegoing prevention of apoptosisPrincipal Investigator
- Principal Investigator
  
  HATAKE Kiyohiko
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Experimental study of gene therapy for malignant glial cells by transfection with IL-12 gene -using SCID mouse model imitating human being-
- Principal Investigator
  
  HASHIMOTO Masaaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Jichi Medical School
Molecular control of the regulation of hemopoiesis and clinical application
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  jichi Medical School
Analysis of collected primitive hemopoietic stem cells and its clinical application
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Isolation concentration, and preservation of hemopoietic stem cells and its clinical
- Principal Investigator
  
  MIURA Yasusada
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School

All 2010 2009 2007 2006 2005 2004

All Journal Article Presentation Patent

[Journal Article] Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways2010
- Author(s)
  Kobayashi T, Kuroda J, Ashihara E, Oomizu S, Terui Y, Taniyama A, Adachi S,Takagi T, Yamamoto M, Sasaki N, Horiike S, Hatake K, Yamauchi A, Hirashima M, Taniwaki M.
- Journal Title
  
  Leukemia. 24
  
  Pages: 843-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Circulating tumor cells as a surrogate marker for determining Responseto chemotherapy in patients with advanced gastric cancer2010
- Author(s)
  Matsusaka S, Chin K, Ogura M, Suenaga M, Shinozaki E, Mishima Y, Terui Y, Mizunuma N, Hatake K.
- Journal Title
  
  Cancer Sci. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Dlk-1, a cell surface antigen on fetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency2010
- Author(s)
  Yanai H, Nakamura K, Hijioka S, Kamei A, Ikari T, Ishikawa Y, Shinozaki E, Mizunuma N, Hatake K, Miyajima A.
- Journal Title
  
  J Biochem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells2009
- Author(s)
  Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S, Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 2085-92
- NAID
  10027196865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy2009
- Author(s)
  Ennishi D, Asai H, Maeda Y, Shinagawa K, Ikeda K, Yokoyama M, Terui Y, Takeuchi K, Yoshino T, Matsuo K, Hatake K, Tanimoto M.
- Journal Title
  
  Ann Oncol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Breast Possible use of combination chemotherapy with mitomycin C and methotrexate for metastatic breast cancer pretreated with anthracycline and taxanes2009
- Author(s)
  Tanabe M, Ito Y, Tokudome N, Sugihara T, Miura H, Takahashi S, Seto Y, Iwase T, Hatake K
- Journal Title
  
  Cancer. 16
  
  Pages: 301-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Familial sideroblastic anemia associated with cardiac atrial septal defect. A2009
- Author(s)
  Mori M, Nakamoto S, Akifuji Y, Tanaka T, Komatsu N, Hatake K, Ozawa K.
- Journal Title
  
  Am J Hematol. 84
  
  Pages: 451-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Chemotherapy for small-bowel Adenocarcinoma at a single institution2009
- Author(s)
  Suenaga M, Mizunuma N, Chin K, Matsusaka S, Shinozaki E, Oya M, Ueno M, Yamaguchi T, Muto T, Konishi F, Hatake K.
- Journal Title
  
  Surg Today. 39
  
  Pages: 27-31
- NAID
  10025130745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Identification of CD20 C-terminal deletion mutations associated with loss of CD20 expression in non-Hodgkin's lymphoma2009
- Author(s)
  Terui Y, Mishima Y, Sugimura N, Kojima K, Sakurai T, Mishima Y, Kuniyoshi R, Taniyama A, Yokoyama M, Sakajiri S, Takeuchi K, Watanabe C, Takahashi S, Ito Y, Hatake K.
- Journal Title
  
  Clin Cancer Res. 15
  
  Pages: 2523-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] An imaging-based rapid evaluation method for complement-dependent cytotoxicity discriminated clinical response to rituximab-containing chemotherapy2009
- Author(s)
  ishima Y, Sugimura N, Matsumoto-Mishima Y, Terui Y, Takeuchi K, Asai S, Ennishi D, Asai H, Yokoyama M, Kojima K, Hatake K.
- Journal Title
  
  Clin Cancer Res. 15
  
  Pages: 3624-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Management of venous thromboembolism in colorectal cancer patients treated with bevacizumab2009
- Author(s)
  Suenaga M, Mizunuma N, Kobayashi K, Shinozaki E, Matsusaka S, Chin K, Kuboki Y, Ichimura T, Ozaka M, Ogura M, Fujiwara Y, Matsueda K, Konishi F, Hatake K.
- Journal Title
  
  Med Oncol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Next generation molecular targeted agents for breast cancer: focus on EGFR and VEGFR pathways.2007
- Author(s)
  Hatake K, et. al.
- Journal Title
  
  Breast Cancer 14
  
  Pages: 132-49
- NAID
  10019480566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Blockade of bulky lymphoma-associated CD55 expression by RNA interference overcomes resistance to CDC with rituximab.2006
- Author(s)
  Terui Y, Sakurai T, Mishima Y, Mishima Y, Sugimura N, Sasaoka C, Kojima K, Yokoyama M, Mizunuma N, Takahashi S, Ito Y, Hatake K
- Journal Title
  
  Cancer Science 97(1)
  
  Pages: 72-79
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Gene therapy for breast cancer. -- Review of clinical gene therapy trials for breast cancer and MDR1 gene therapy trial in Cancer Institute Hospital.2006
- Author(s)
  S Takahashi, Y Ito, K Hatake, Y Sugimoto
- Journal Title
  
  Breast Cancer 13(1)
  
  Pages: 8-15
- NAID
  10017238537
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Differential Regulation of Eotaxin-1/CCL11 and Eotaxin-3/CCL26 Production by the TNF-a and IL-4 stimulated Human Lung Fibroblast.2006
- Author(s)
  Rokudai A, Terui Y, Kuniyoshi R, Mishima Y, Mishima Y, Aizu-Yokota Y, Sonoda Y, Kasahara T, Hatake K
- Journal Title
  
  Biol.Pharm.Bull. 29(In press)
- Data Source
  KAKENHI-PROJECT-17016077
[Journal Article] Element array by scanning X-ray fluorescence microscopy after cis-diamminedichloro-platinum (II) treatment.2005
- Author(s)
  Shimura M, Saito A, Matsuyama S, Sakuma T, Terui Y, Ueno K, Yumoto H, Yamauchi K, Yamamura K, Mimura H, Sano Y, Yabashi M, Tamasaku K, Nishio K, Nishino Y, Endo K, Hatake K, Mori Y, Ishizaka Y, Ishikawa T:
- Journal Title
  
  Cancer Res 65
  
  Pages: 4998-5002
- Data Source
  KAKENHI-PROJECT-17016077
[Patent] 抗体医薬感受性検査方法2007
- Inventor(s)
  杉村夏彦, 三嶋雄二, 畠清彦
- Industrial Property Rights Holder
  財団法人癌研究会オリンパス株式会社
- Filing Date
  2007-09-26
- Overseas
- Data Source
  KAKENHI-PROJECT-17016077
[Patent] Fc受容体遺伝子導入NK細胞株、その作製方法、及びこれを用いた抗体依存性細胞障害のアッセイ方法2007
- Inventor(s)
  杉村夏彦, 三嶋雄二, 畠清彦
- Industrial Property Rights Holder
  財団法人癌研究会オリンパス株式会社
- Industrial Property Number
  2007-254099
- Filing Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-17016077
[Patent] 抗体医薬感受性検査方法2006
- Inventor(s)
  杉村夏彦, 三嶋雄二, 照井康仁, 畠清彦
- Industrial Property Rights Holder
  (財)癌研究会, オリンパス株式会社
- Filing Date
  2006-09-26
- Data Source
  KAKENHI-PROJECT-17016077
[Patent] 抗体医薬感受性検査方法2006
- Inventor(s)
  杉村夏彦、三嶋雄二、照井康仁、畠清彦
- Industrial Property Rights Holder
  (財)癌研究会/オリンパス株式会社
- Filing Date
  2006-09-26
- Data Source
  KAKENHI-PROJECT-17016077
[Patent] 癌治療のための薬剤2004
- Inventor(s)
  畠清彦, 照井康仁, 三嶋雄二
- Industrial Property Rights Holder
  森永乳業(株)
- Industrial Property Number
  2004-080454
- Filing Date
  2004-03-19
- Data Source
  KAKENHI-PROJECT-13218136
[Presentation] EGFR標的療法の効果予測のための生細胞イメージング2009
- Author(s)
  三嶋雄二・照井康仁・松阪諭・國吉良子・三嶋裕子・高木浩一・畠清彦
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016077
[Presentation] リツキシマブ既治療再発・難治B・NHLに対するInotuzumab Ozogamic in(CMC・544)の国内第I相試験2009
- Author(s)
  畠清彦他
- Organizer
  日本臨床腫瘍学会
- Place of Presentation
  名古屋
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-17016077

1. TERUI Yasuhito (10285786)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TOMIZUKA Hiroshi (00285785)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. OHTSUKI Tetuya (60275691)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MIURA Yasusada (60048965)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. IMAGAWA Shigehiko (60231164)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. MUROI Kazuo (50190939)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KOMATSU Norio (50186798)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. SHIMIZU Ritsuko (40226262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 角田純一 (20245054)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MIWA Akiyoshi (40200224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUDA Toshio (60118453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. GUNJI Yuji (90245043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKATOKU Masaaki (20285787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HASHIMOTO Masaaki (60221496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAGAI Mutsumi (10265259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 倉田寛一 (90215038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高木省治郎 (20158992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 星野充明 (70275692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMADA Muneo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 池田正幸

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hatake Kiyohiko 畠 清彦

HATAKE Kitohiko 畠 清彦

Research Projects

Research Products

Co-Researchers

Analysis of resistance mechanism of cell death in chemotherapy and monoclonal antibody therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

化学療法と抗体療法における細胞死の耐性機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

内皮細胞との相互作用によるがん細胞のアポトーシス誘導機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Development of treatment strategies for malignancies using novel apoptosis-inducing factors.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病細胞の分化により発現する新規SLAPと分化制御の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of FAP-1 gene undegoing prevention of apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study of gene therapy for malignant glial cells by transfection with IL-12 gene -using SCID mouse model imitating human being-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular control of the regulation of hemopoiesis and clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of collected primitive hemopoietic stem cells and its clinical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation concentration, and preservation of hemopoietic stem cells and its clinical

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways2010

Author(s)

Journal Title

Data Source

[Journal Article] Circulating tumor cells as a surrogate marker for determining Responseto chemotherapy in patients with advanced gastric cancer2010

Author(s)

Journal Title

Data Source

[Journal Article] Dlk-1, a cell surface antigen on fetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency2010

Author(s)

Journal Title

Data Source

[Journal Article] Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells2009

Author(s)

Journal Title

NAID

Data Source

Hatake Kiyohiko 畠清彦

HATAKE Kitohiko 畠清彦