YAHATA TAKASHI 八幡崇

… Alternative Names

YAHATA Takashi 八幡崇

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Researcher Number	10398753
Other IDs	https://orcid.org/0000-0002-9332-0358
Affiliation (Current)	2025: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東海大学, 医学部, 教授 2013 – 2020: 東海大学, 医学部, 准教授 2014: 東海大学, 医学部, 講師 2008 – 2012: Tokai University, 医学部, 講師 2007: Tokai University, School of Medicine, department of Medicine, Assistant Professor 2006: Tokai University, School of Medicine, Assistant Researcher, 医学部, 教授 2005 – 2006: 東海大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General medical chemistry / Laboratory animal science / Basic Section 50010:Tumor biology-related / Tumor biology Except Principal Investigator Hematology / Laboratory animal science / Laboratory animal science / Basic Section 54010:Hematology and medical oncology-related / Basic Section 53020:Cardiology-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields … More / Medium-sized Section 50:Oncology and related fields / Basic Section 49030:Experimental pathology-related / Tumor therapeutics / General medical chemistry Less
Keywords	Principal Investigator 造血幹細胞 / ヒト化モデルマウス / PAI-1 / 再生医療 / 間葉系幹細胞 / ニッチ / 分子標的薬 / 白血病 / 低分子化合物 / 線維素溶解系 … More / 細胞周期 / クローン解析 / プラスミノーゲン活性化阻害因子（PAI-1） / 腫瘍生物学 / 線維素溶解径 / 線溶系 / 創薬 / 免疫チェックポイント / がん免疫療法 / がん / MT1-MMP / 治療抵抗性 / 繊維素溶解系 / 薬剤耐性 / がん幹細胞 / TGF-b / 白血病幹細胞 / TGF-beta / 幹細胞 / cell cycle / cord blood / intra-bone marrow transplantation / mesehcnymal stem cells / humanized mouse / niche / hematopoietic stern cells / 造血制御 / 造血環境 / ヒトビモデンレマウス / 臍帯血 / 骨髄内移植 / Mesenchymal Stem Cell / Self-renewal ability / Hematopoietic Microenvironment / Clonal Analysis / Humanized mouse / Leukemia / Hematopoietic Stem Cell / Human / LAM-PCR法 / 骨髄内移植法 / モデル動物 / 自己複製能 / 骨髄内造血微小環境 / ヒト / 再生 / 造血再生 / 幹細胞移植 / 自己複製 / DNA損傷 / ヒト化モデル動物 / DNA障害 / 酸化ストレス / 移植 / 再生医学 / 間系幹細胞 / 骨髄移植 … More Except Principal Investigator Notch / PAI-1 / 造血幹細胞 / CD34 / 骨髄異形成症候群 / 多発性骨髄腫 / 免疫不全マウス / FLT3-ITD / PML-RARA / NOGマウス / 急性骨髄性白血病 / 骨芽細胞 / 骨代謝 / プラスミノーゲン活性化抑制因子（PAI-1） / 運動能の制御 / がん治療 / 再生医療 / 細胞運動能制御 / がん幹細胞 / 幹細胞 / 癌転移 / 動脈血栓 / 静脈血栓 / 動脈血栓症 / 静脈血栓症 / 発生工学 / SEND / マウス / mRNA転送 / ウイルス様粒子 / 白血病 / 遺伝子治療 / ゲノム編集 / mev1 / 造血ホメオスタシス / 造血幹細胞移植 / 活性酸素 / myeloid-skewing / ROS過剰産生 / Sdhc変異マウス / 脂肪細胞 / 全エクソン解析 / ROS / ミトコンドリア複合体II / complex II / ミトコンドリア / 全エクソンシークエンス / Sdhc-mut マウス / 酸化ストレス / 人環境マウス / ニッチ間相互作用 / ヒト環境マウス / インタラクトーム / ニッチ / 創薬 / 急性リンパ球性白血病 / 悪性腫瘍 / LMO2 / 抗腫瘍薬 / Lmo2 / T-ALL / 血液腫瘍 / Intra-BM transplantation / Myelodysplastic syndrome / BM niche / Immunedeficient mice / Hematopoietic stem cells / クローン / 骨髄内移植 / 骨髄ニッチ / ヒト造血細胞 / Delta-like 1 / リモデリング / Delta-like1 / Jagged1 / リガンド特異性 / Notchシグナル / in vivoモデル / 臍帯血由来CD34陽性細 / NPM1 / DNMT3A / 臍帯血由来CD34陽性細胞 / ヒトCD34陽性細胞 / 遺伝子変異 / epigenetics / 骨髄微小環境 / microenvironment / xenograft / humanized mice / multiple myeloma / 個別衣料 / ヒト化モデル / 免疫不全動物 / 個別化医療 / 実験動物 / 個別医療 / 実験動物学 / ヒト化マウス / レチノイン酸 / 白血病幹細胞 / ヒト臍帯血 / 急性前骨髄球性白血病 / ヒト臍帯血CD34陽性細胞 / class II異常 / class I異常 / 破骨細胞 / 造骨細胞 / 造血代謝 / 造血恒常性 / niche / 骨と骨髄 / 再生医学 Less

内在性分子で構築されたウイルス様粒子による細胞間mRNA転送の特性の解明と応用
- Principal Investigator
  
  大塚正人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Tokai University
Development of novel anti-platelet agents targeting CLEC-2 and GPVI and assessment of their therapeutic targets
- Principal Investigator
  
  渡邊伸央
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokai University
Elucidation of stem cell motility mechanism and its application to regeneration and cancer therapy
- Principal Investigator
  
  アブドゥルアジズ
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokai University
Establishment of novel combination cancer immunotherapy targeting regulators of the fibrinolytic systemPrincipal Investigator
- Principal Investigator
  
  八幡崇
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokai University
Development of novel genome editing tool for gene therapy and its application to cancer therapy
- Principal Investigator
  
  Ohtsuka Masato
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Tokai University
An analysis for development of myelodysplastic syndrome and influence of ROS
- Principal Investigator
  
  ONIZUKA Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Tokai University
Analysis of interraction of multiple myeloma cells and bone marrow stroma cells using xenograft models
- Principal Investigator
  
  ANDO Kiyoshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
The exploration of new drug for the treatment of Notch-active tumor cells.
- Principal Investigator
  
  ANDO Kiyoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokai University
Blockade of PAI-1 eliminates leukemic stem cellsPrincipal Investigator
- Principal Investigator
  
  YAHATA Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokai University
Maintenance of bone homeostasis by DLL1-mediated Notch activation
- Principal Investigator
  
  NAKAYAMA-MUGURUMA YUKARI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Establishment of hematopoietic regeneration by the novel molecular targeting drugPrincipal Investigator
- Principal Investigator
  
  YAHATA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokai University
In vivo analysis of gene mutations related to epigenetic alterations in acute myeloid leukemia
- Principal Investigator
  
  MATSUSHITA Hiromichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokai University
Analysis of Multiple myeloma pahtophysiology using xenograft model having humanized BM microenvironment
- Principal Investigator
  
  MUGURUMA Yukari
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Development of experimentation systems related to personalized medicine using humanized NOG mice
- Principal Investigator
  
  ITO Mamoru
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
DNA damage response in human hematopoietic stem cellPrincipal Investigator
- Principal Investigator
  
  YAHATA Takashi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokai University
Genetic abnormality require their specific differentiation stage in leukemogenensis
- Principal Investigator
  
  MATSUSHITA Hiromichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokai University
Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis
- Principal Investigator
  
  NAKAYAMA Yukari
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokai University
Analysis of repopulating dynamics of human hematopoietic stem cellsPrincipal Investigator
- Principal Investigator
  
  YAHATA Takashi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokai University
Molecular mechanism of leukemica stem cells maintenance in vivo
- Principal Investigator
  
  ANDO Kiyoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokai University
Establishment of human hematopoietic system model mouse for understanding the regulatory mechanisms of human hematopoiesis.Principal Investigator
- Principal Investigator
  
  YAHATA Takashi, 中山ゆかり (六車ゆかり)
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Establishment of a novel in vivo model of human leukemiaPrincipal Investigator
- Principal Investigator
  
  YAHATA Takashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University

[Book] iPS細胞による鎌状貧血の治療2009
- Author(s)
  八幡崇
- Total Pages
  5
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-20790238
[Book] 血液・腫瘍科(インターフェロンaは造血幹細胞を細胞周期に導入する)2009
- Author(s)
  八幡崇
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20790238
[Book] 血液フロンティア(iPS細胞による鎌状貧血の治療)2008
- Author(s)
  八幡崇
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-20790238
[Journal Article] Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 12023
- Author(s)
  Ibrahim Abd Aziz, Fujimura Taku, Uno Tomoko, Terada Tomoya, Hirano Ken-ichi, Hosokawa Hiroyuki, Ohta Akio, Miyata Toshio, Ando Kiyoshi, Yahata Takashi,
- Journal Title
  
  Frontiers in Immunology
  
  Volume: -
- DOI
  10.21203/rs.3.rs-3637984/v1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07820
[Journal Article] Mitochondrial Electron Transport Chain Complex II Dysfunction Causes Premature Aging of Hematopoietic Stem Cells2023
- Author(s)
  Kaito Harada, Takashi Yahata, Makoto Onizuka, Takamasa Ishii, Abd Aziz Ibrahim, Eri Kikkawa, Yoichi Gondo, Kiyoshi Ando
- Journal Title
  
  Stem Cells
  
  Volume: 41(1) Issue: 1 Pages: 39-49
- DOI
  10.1093/stmcls/sxac072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-23K21386
[Journal Article] Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells2022
- Author(s)
  Kawakami Shohei、Tsuma-Kaneko Mitsuyo、Sawanobori Masakazu、Uno Tomoko、Nakamura Yoshihiko、Matsuzawa Hideyuki、Suzuki Rikio、Onizuka Makoto、Yahata Takashi、Naka Kazuhito、Ando Kiyoshi、Kawada Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 04654-1
- DOI
  10.1038/s41598-021-04654-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07897, KAKENHI-PROJECT-20H03517, KAKENHI-PROJECT-21K19353, KAKENHI-PROJECT-23K21386
[Journal Article] LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice2021
- Author(s)
  Hirano K., Hosokawa H., Koizumi M., Endo Y., Yahata T., and Hozumi K
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.68227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-20K07330, KAKENHI-PROJECT-23K21386
[Journal Article] IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform2021
- Author(s)
  Harama Daisuke、Yahata Takashi、Kagami Keiko、Abe Masako、Ando Norie、Kasai Shin、Tamai Minori、Akahane Koshi、Inukai Takeshi、Kiyokawa Nobutaka、Ibrahim Abd Aziz、Ando Kiyoshi、Sugita Kanji
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41420-021-00523-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-23K21386
[Journal Article] Plasminogen activator inhibitor type-1 is a negative regulator of hematopoietic regeneration in the adipocyte-rich bone marrow microenvironment2021
- Author(s)
  Harada Kaito、Yahata Takashi、Onizuka Makoto、Ibrahim Abd Aziz、Kikkawa Eri、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 557 Pages: 180-186
- DOI
  10.1016/j.bbrc.2021.04.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-18K07073, KAKENHI-PROJECT-20K22941, KAKENHI-PROJECT-23K21386
[Journal Article] Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium2021
- Author(s)
  Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K.
- Journal Title
  
  Front Immunol
  
  Volume: 13 Pages: 852427-852427
- DOI
  10.3389/fimmu.2022.852427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330, KAKENHI-PROJECT-22K08042, KAKENHI-PROJECT-23K21386
[Journal Article] Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning2019
- Author(s)
  Ibrahim Abd Aziz、Yahata Takashi、Muguruma Yukari、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 516(2) Issue: 2 Pages: 500-505
- DOI
  10.1016/j.bbrc.2019.06.076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-17H03572
[Journal Article] TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche2017
- Author(s)
  Yahata Takashi、Ibrahim Abd Aziz、Muguruma Yukari、Eren Mesut、Shaffer Alexander M.、Watanabe Nobuo、Kaneko Satoko、Nakabayashi Tetsuo、Dan Takashi、Hirayama Noriaki、Vaughan Douglas E.、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Blood
  
  Volume: 130 Issue: 21 Pages: 2283-2294
- DOI
  10.1182/blood-2017-02-767384
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-15K10523
[Journal Article] Jagged 1-induced Notch activatio contributes to the acquisition of bortezomib resistance in myeloma cells2017
- Author(s)
  Yukari Muguruma, Takashi Yahata, Takayuki Warita, Katsuyo Hozumi, Yoshihiko Nakamura, Rikio Suzuki, Mamoru Ito, Kiyoshi Ando
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 7 Issue: 12 Pages: 1408-1408
- DOI
  10.1038/s41408-017-0001-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04287, KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-16K14635
[Journal Article] Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling.2017
- Author(s)
  Muguruma Y, Hozumi K, Warita H, Yahata T, Uno T, Ito M, Ando K.
- Journal Title
  
  J Cell Physiol.
  
  Volume: 印刷中 Issue: 9 Pages: 2569-2580
- DOI
  10.1002/jcp.25647
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-26430094, KAKENHI-PROJECT-17H03572
[Journal Article] Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model2017
- Author(s)
  Matsuzawa H, Matsushita H, Yahata T, Tanaka M, Ando K.
- Journal Title
  
  Tokai Journal of Experimental Clinical Medicine
  
  Volume: 42 Pages: 41-51
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04301
[Journal Article] Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model.2017
- Author(s)
  Matsuzawa H, Matsushita H, Yahata T, Tanaka M, Ando K.
- Journal Title
  
  Tokai J Exp Clin Med.
  
  Volume: 42 Pages: 41-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04301
[Journal Article] Common marmoset CD117-positive hematopoietic cells possess multipotency2015
- Author(s)
  Shimada S, Nunomura S, Mori S, Suemizu H, Itoh T, Takabayashi S, Okada Y, Yahata T, Shiina T, Katoh H, Suzuki R, Tani K, Ando K, Yagita H, Habu S, Sasaki E, Kametani Y.
- Journal Title
  
  Int Immune
  
  Volume: 27 Issue: 11 Pages: 567-577
- DOI
  10.1093/intimm/dxv031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-25430095
[Journal Article] Functional analysis of the SEPT9-ABL1 chimeric fusion gene derived from T-prolymphocytic leukemia.2014
- Author(s)
  Kawai H, Matsushita H, Suzuki R, Sheng Y, Lu J, Matsuzawa H, Yahata T, Tsuma-Kaneko M, Tsukamoto H, Kawada H, Ogawa Y, Ando K.
- Journal Title
  
  Leukemia Research.
  
  Volume: 38 Issue: 12 Pages: 1451-1559
- DOI
  10.1016/j.leukres.2014.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-24591411
[Journal Article] Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration.2014
- Author(s)
  IbrahimAA,Yahata T,Onizuka M,Dan T,Van Yperscle De Stribou C,Miyata T,Ando K
- Journal Title
  
  Stem Cells,
  
  Volume: 32 Issue: 4 Pages: 946-958
- DOI
  10.1002/stem.1577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390248, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-26890022
[Journal Article] Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice2014
- Author(s)
  Matsushita, H. Yahata, T. Sheng, Y. Nakamura, Y. Muguruma, Y. Matsuzawa, H. Tanaka, M. Hayashi, H. Sato, T. Damdinsuren, A. Onizuka, M. Ito, M. Miyachi, H. Pandolfi, P. P. Ando, K.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 11 Pages: e111082-e111082
- DOI
  10.1371/journal.pone.0111082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-24591411, KAKENHI-PROJECT-26430094
[Journal Article] Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged-12014
- Author(s)
  Negishi, N. Suzuki, D. Ito, R. Irie, N. Matsuo, K. Yahata, T. Nagano, K. Aoki, K. Ohya, K. Hozumi, K. Ando, K. Tamaoki, N. Ito, M. Habu, S.
- Journal Title
  
  Exp Hematol
  
  Volume: 42 Issue: 6 Pages: 487-94
- DOI
  10.1016/j.exphem.2014.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-25430099
[Journal Article] RUNX1/AML1 mutant collaborates with BMI1 overexpression in tnedevelopment of human and murine myelodysplastic syndromes.2013
- Author(s)
  原田結花、井上大地, 他
- Journal Title
  
  Blood
  
  Volume: 128(3) Issue: 17 Pages: 3434-3446
- DOI
  10.1182/blood-2012-06-434423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04145, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-23249051, KAKENHI-PROJECT-23310183, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24591398, KAKENHI-PROJECT-24591411, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-25461422
[Journal Article] Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.2013
- Author(s)
  Inoue S, Sato T, Suzuki-Utsunomiya K, Komori Y, Hozumi K, Chiba T, Yahata T, Nakai K, Inokuchi S.
- Journal Title
  
  Shock
  
  Volume: 39 Issue: 3 Pages: 311-316
- DOI
  10.1097/shk.0b013e3182845445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590361, KAKENHI-PUBLICLY-23118529
[Journal Article] RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.2013
- Author(s)
  Harada Y, Inoue D, Ding Y, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Sashida G, Iwama A, Kitamura T, Harada H.
- Journal Title
  
  Blood
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-24591411
[Journal Article] Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells2011
- Author(s)
  Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
- Journal Title
  
  Blood
  
  Volume: 118(11) Pages: 2941-50
- NAID
  40019489714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500501
[Journal Article] Establishment of a xenograft model of human myelodysplastic syndromes.2011
- Author(s)
  Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
- Journal Title
  
  Haematologica. 96(4)
  
  Pages: 543-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590289
[Journal Article] Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells2011
- Author(s)
  Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
- Journal Title
  
  Blood
  
  Volume: 118(11) Pages: 2941-50
- NAID
  40019489714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790299
[Journal Article] Establishment of xenograft model of human myelodysplastic syndromes2011
- Author(s)
  Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
- Journal Title
  
  Haematologica
  
  Volume: Vol.96, No.4 Pages: 543-551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591224
[Journal Article] Establishment of a xenograft model of human myelodysplastic syndromes2011
- Author(s)
  Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
- Journal Title
  
  Haematologica
  
  Volume: 96(4) Pages: 543-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500501
[Journal Article] Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells2011
- Author(s)
  Yahata, T.
- Journal Title
  
  Blood
  
  Volume: 118 Issue: 11 Pages: 2941-2950
- DOI
  10.1182/blood-2011-01-330050
- NAID
  40019489714
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-22790299, KAKENHI-PROJECT-23500501
[Journal Article] Establishment of xenograft model of human myelodysplastic syndromes2011
- Author(s)
  Muguruma Y, Matsushita H, Yahata H, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
- Journal Title
  
  Haematologica
  
  Volume: 96 Issue: 4 Pages: 543-551
- DOI
  10.3324/haematol.2010.027557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591224, KAKENHI-PROJECT-22790299, KAKENHI-PROJECT-23500501
[Journal Article] MDS stem cells suppress normal hematopoiesis by niche invasion and microenvironment disruption2011
- Author(s)
  Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
- Journal Title
  
  Haematologica
  
  Volume: 96(4) Pages: 543-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790299
[Journal Article] 造血幹細胞ニッチ2010
- Author(s)
  八幡崇
- Journal Title
  
  Medical Science Digest
  
  Volume: 36巻6号 Pages: 2-4
- Data Source
  KAKENHI-PROJECT-22790299
[Journal Article] Adipocyte-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo : advantages over bone marrow-derived mesenchymal stem cells2010
- Author(s)
  Nakao N, Nakayama T, Yahata T, Muguruma Y, Miyata Y, Naoe T
- Journal Title
  
  Am J Pathol
  
  Volume: 117(2) Pages: 547-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790299
[Journal Article] Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo : advantages over bone marrow-derived mesenchymal stem cells.2010
- Author(s)
  Nakao N, Nakayama T, Yahata T, Muguruma Y, Saito S, Miyata Y, Yamamoto K, Naoe T.
- Journal Title
  
  Am J Pathol. 177(2)
  
  Pages: 547-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590289
[Journal Article] FACSを用いたヒト造血幹細胞の生体内における性状解析2009
- Author(s)
  八幡崇、六車ゆかり、安藤潔
- Journal Title
  
  Cytometry Research 19(2)
  
  Pages: 19-23
- NAID
  10026084405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790238
[Journal Article] FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression2009
- Author(s)
  Jin G, Matsushita H, Asai S, Tsukamoto H, Ono R, Nosaka T, Yahata T, Takahashi S, Miyachi H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Vol.390, No.3 Pages: 1001-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591224
[Journal Article] FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression.2009
- Author(s)
  Jin G, Matsushita H, Asai S, Tsukamoto H, Ono R, Nosaka T, Yahata T, Takahashi S, Miyachi H.
- Journal Title
  
  Biochem Biophys Res Commun. 390(3)
  
  Pages: 1001-1006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790238
[Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis.2008
- Author(s)
  Yahata, et al.
- Journal Title
  
  stem Cells. 26(12)
  
  Pages: 3238-3236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590289
[Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis.2008
- Author(s)
  Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K.
- Journal Title
  
  Stem Cells. 26(12)
  
  Pages: 3228-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590289
[Journal Article] Humanizing bone marrow in immune-deficient mice.2008
- Author(s)
  Ando K, Muguruma Y, Yahata T
- Journal Title
  
  Curr Top Microbiol Immunol. 324(Review)
  
  Pages: 77-86
- Data Source
  KAKENHI-PROJECT-20590289
[Journal Article] Quiescent human hematopoietic stem cells in the bone m arrow niches organize the hierarchical structure of hemat opoiesis2008
- Author(s)
  Yahata T., et.al.
- Journal Title
  
  Stem Cells 26
  
  Pages: 3228-3236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790238
[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008
- Author(s)
  Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, Zuklys S, Hollander GA, Shima DT, Habu S
- Journal Title
  
  J Exp Med. 205(11)
  
  Pages: 2507-2513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790238
[Journal Article] Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development.2008
- Author(s)
  Sheng Y, Yahata T, Negishi N, Nakano Y, Habu S, Hozumi K, Ando K
- Journal Title
  
  Immunol Lett. 121(1)
  
  Pages: 33-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790238
[Journal Article] Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis.2008
- Author(s)
  Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K.
- Journal Title
  
  Stem Cells. 26(12)
  
  Pages: 3228-3236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790238
[Journal Article] Angiopoietin-linduces SRC activity of human CD34-bone marrow cells2007
- Author(s)
  Nakamura Y., Yahata T., Muguruma Y., Uno T., Sato T., Matuzawa Y., Kato S., Shirasugi Y., Hotta T., Ando K.
- Journal Title
  
  Exp Hematol 35
  
  Pages: 1872-1883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells.2006
- Author(s)
  Yahata, T
- Journal Title
  
  Blood 108・7
  
  Pages: 9-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17500290
[Journal Article] Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment2006
- Author(s)
  Muguruma Y, Yahata T, tho J, Itho M, Kato S, Hotta T, Ando K
- Journal Title
  
  Blood 107
  
  Pages: 1878-1887
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells.2006
- Author(s)
  Yahata, T.
- Journal Title
  
  Blood 108-7
  
  Pages: 9-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500290
[Journal Article] Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic cells2006
- Author(s)
  Yahata, T et al.
- Journal Title
  
  Blood 108・7
  
  Pages: 2446-2454
- Data Source
  KAKENHI-PROJECT-18500332
[Journal Article] Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment.2006
- Author(s)
  Muguruma Y, Yahata T, tho J, Itho M, Kato S, Hotta T, Ando K
- Journal Title
  
  Blood 107
  
  Pages: 1878-1887
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Direct evidence for ex vivo expansion of human hematopoietic stem cells.2006
- Author(s)
  Ando K, Yahata T, Sato T, Miyatake H, Miyoshi H, Tsuji T, Kato S, Hotta T.
- Journal Title
  
  Blood 107
  
  Pages: 3371-3377
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Direct evidence for ex vivo expansion of human hematopoietic stem cells2006
- Author(s)
  Ando K, Yahata T, Sato T, Miyatake H, Miyoshi H, Tsuji T, Kato S, Hotta T.
- Journal Title
  
  Blood 107
  
  Pages: 3371-3377
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells.2006
- Author(s)
  Yahata T, Yumino S, Sheng Y, Miyatake H, Uno T, Muguruma Y, Ito M, Miyoshi H, Kato S, Hotta T, Ando K.
- Journal Title
  
  Blood 108
  
  Pages: 2446-2454
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Clonal anlysis of thymus-repopulatint cells presents direct evidence for Self-rebewal division of human hematopoietic stem cells2006
- Author(s)
  Yahata, T, et. al.
- Journal Title
  
  Blood 108
  
  Pages: 2446-2454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Measuring human hematopoietic stem cells.2006
- Author(s)
  Ando K, Yahata T.
- Journal Title
  
  Blood 108
  
  Pages: 771-772
- Data Source
  KAKENHI-PROJECT-18390285
[Journal Article] Establishment of xenograft model of human myelodysplastic syndromes.
- Author(s)
  Muguruma, Matsushita, Yahata, Yumino, Tanaka, Miyachi, Ogawa, Kawada, Ito, Ando
- Journal Title
  
  Haematologica
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591224
[Journal Article] Adipocyte-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo: advantages over bone marrow-derived mesenchymal stem cells.
- Author(s)
  Nakao N, Nakayama T, Yahata T, Muguruma Y, Miyata Y, Naoe T.
- Journal Title
  
  Am J Pathol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790238
[Patent] PAI-1阻害剤の新規用途2014
- Inventor(s)
  安藤　潔、八幡　崇、宮田　敏男
- Industrial Property Rights Holder
  安藤　潔、八幡　崇、宮田　敏男
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-15
- Overseas
- Data Source
  KAKENHI-PROJECT-24590361
[Presentation] MITOCHONDRIAL ELECTRON TRANSPORT CHAIN COMPLEX II DYSFUNCTION DRIVES PREMATURE AGING OF HEMATOPOIETIC STEM CELLS2020
- Author(s)
  Kaito Harada*, Takashi Yahata, Makoto Onizuka, Takamasa Ishii, Abd Aziz Ibrahim, Eri Kikkawa, Yoichi Gondo, Kiyoshi Ando
- Organizer
  第25回欧州血液学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07073
[Presentation] Mitochondrial complex II dysfunction leads to hematopoietic stem cells aging and myelodysplastic syndrome2020
- Author(s)
  Kaito Harada*, Takashi Yahata, Makoto Onizuka, Takamasa Ishii, Abd Aziz Ibrahim, Eri Kikkawa, Yoichi Gondo,Kiyoshi Ando
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K07073
[Presentation] Pharmacological Inhibition of PAI-1 Empties BM Niche Without Myeloablative Conditioning2019
- Author(s)
  Abd Aziz Ibrahim,八幡　崇、安藤　潔
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03572
[Presentation] Bone Marrow Adipocyte-Derived PAI-1 As a Negative Regulator of Hematopoietic Regeneration2019
- Author(s)
  Kaito Harada, Takashi Yahata, Kiyoshi Ando
- Organizer
  Annual Meeting of the ASH
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03572
[Presentation] PAI-1活性の阻害による慢性骨髄性白血病幹細胞の治療高感受性2018
- Author(s)
  八幡崇、Abd Aziz Ibrahim, 仲一仁、宮田敏男、安藤潔
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03572
[Presentation] G-CSF-induced cAMP-PKA-CREB pathway counteracts TGF-β-PAI-1 signaling-dependent retention of HSCs2017
- Author(s)
  Abd Aziz Ibrahim, Takashi Yahata
- Organizer
  第７９回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] G-CSF-induced cAMP-PKA-CREB pathway counteracts TGF-β-PAI-1 signaling-dependent retention of HSCs in the niche2017
- Author(s)
  Takashi Yahata
- Organizer
  59th American Society of Hematology Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] Jagged-1-Notch interaction in the niche is responsible for acquisition of drug-resistance2016
- Author(s)
  六車ゆかり、八幡　崇
- Organizer
  第７８回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] Intracellular PAI-1 is a critical regulator of hematopoietic stem and progenitor cell localization in the niche2016
- Author(s)
  Yahata T, Ibrahim AA, Muguruma Y, Kaneko S, Miata T, Ando K
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA
- Year and Date
  2016-02-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] TGF-b induced intracellular PAI-1 is a critical regulator HSC localization in the niche2016
- Author(s)
  アブドゥルアジズ、八幡　崇
- Organizer
  第７８回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] Jagged1-Notch interaction in the niche is responsible for acquisition of drug-resistance2016
- Author(s)
  Muguruma Y, Hozumi K, Warita H, Yahata T, Uno T, Ito M, Ando K
- Organizer
  日本血液学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-26430094
[Presentation] Intracellular PAI1 is a critical regulator of stem cell localization in the niche2016
- Author(s)
  Takashi Yahata, Abd Aziz Ibrahim, Yukari Muguruma, Toshio Miyata, Kiyosi Ando
- Organizer
  Gordon Conference
- Place of Presentation
  Four Points Sheraton (CA, USA)
- Year and Date
  2016-02-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430094
[Presentation] Identification of molecular interactions in MM nich in vivo2015
- Author(s)
  Yukari Muguruma, Takashi Yahata, Takayuki Warita, Yoshihiko Nakamura, Rikio Suzuki, Shumpei Ishikawa, Takayuki Isagawa,Kiyoshi Ando
- Organizer
  日本血液学会
- Place of Presentation
  ホテル日航金沢(石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26430094
[Presentation] 超免疫不全マウスを利用したヒト造血再生の解析2014
- Author(s)
  八幡　崇
- Organizer
  第４７回日本無菌生物ノートバイオロジー学会
- Place of Presentation
  アルカディア市ヶ谷
- Data Source
  KAKENHI-PROJECT-24590361
[Presentation] Functional analysis of SEPT9-ABL1 chimeric fusion gene derived from T-prolymphocytic leukemia2013
- Author(s)
  Kawai H, Matsushita H, Suzuki R, Sheng Y, Lu J, Yahata T, Matsuzawa H, Tsukamoto H, Kawada H, Ogawa Y, Ando K
- Organizer
  第７５回　日本血液学会学術集会
- Place of Presentation
  ロイトン札幌、札幌市
- Data Source
  KAKENHI-PROJECT-24591411
[Presentation] Functional analysis of SEPT9-ABL1 chimeric fusion gene derived from T-prolymphocytic leukemia2013
- Author(s)
  Kawai H, Matsushita H, Suzuki R, Sheng Y, Lu J, Matsuzawa H, Yahata T, Kaneko M, Tsukamoto H, Kawada H, Ogawa Y, Ando K
- Organizer
  55th ASH Annual Meeting and Exposition
- Place of Presentation
  Ernest N. Morial Convention Center, New Orleans, LA
- Data Source
  KAKENHI-PROJECT-24591411
[Presentation] ニッチ因子を標的とした新規造血促進薬の開発2013
- Author(s)
  八幡　崇
- Organizer
  第２３回日本サイトメトリー学会
- Place of Presentation
  日本医科大学
- Invited
- Data Source
  KAKENHI-PROJECT-24590361
[Presentation] 免疫不全マウスを用いたヒト造血幹細胞老化メカニズムの解析2013
- Author(s)
  八幡　崇
- Organizer
  第４６回日本無菌生物ノートバイオロジー学会総会
- Place of Presentation
  神奈川県
- Invited
- Data Source
  KAKENHI-PROJECT-24590361
[Presentation] Antibody-Secreting B Cells are Directly Developed from Transitional B cells of Humanized NOG Mice.2013
- Author(s)
  Kametani, Y., Mori, S., Shimada, S., Oshima, S., Aokawa, J., Okada, Y., Goto, Y., Tsuda, B., Yahata, T., Ito, R., Katano, I., Suemizu, H., Ito, M., Habu, S. and Ando, K.
- Organizer
  第4回国際ヒト化マウスワークショップ
- Place of Presentation
  ソウル
- Data Source
  KAKENHI-PROJECT-22220007
[Presentation] CD34+/CD38+ cells from human cord blood initiate APL by induction of PML-RARA2012
- Author(s)
  Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Ando K
- Organizer
  JSH International Symposium
- Place of Presentation
  川越プリンスホテル
- Data Source
  KAKENHI-PROJECT-23500501
[Presentation] Non-telomeric stem cell aging in hematopoietic regeneration2012
- Author(s)
  八幡　崇
- Organizer
  第７４回日本血液学会学術集会
- Place of Presentation
  京都府
- Data Source
  KAKENHI-PROJECT-24590361
[Presentation] Non-telomeric stem cell aging in hematopoietic regeneration2012
- Author(s)
  Takashi Yahata, Tomoni Takanashi, Yukari Muguruma, Abd Aziz Ibrahim, Hiedyuki Matsuzawa, Tomoko Uno, Yin Sheng, Makoto Onizuka, Mamoru Ito, Shyunichi Kato, Kiyoshi Ando
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23500501
[Presentation] unctional analysis of SEPT9-ABL1 chimeric fusion gene derived from T-prolymphocytic leukemia.2012
- Author(s)
  Matsushita H, Suzuki R, Sheng Y, Yahata T, Matsuzawa H, Tsukamoto H, Kawai H, Kawada H, Ogawa Y, Miyachi H, Ando K
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-24591411
[Presentation] CD34+/CD38+ cells from human cord blood onotoate APL by induction of PML-RARA2012
- Author(s)
  Hiromichi Matsushita, Takashi Yahata, Yoshihiko Nakamura, Yin Sheng, Yukari Muguruma, et al.
- Organizer
  JSH International Symposium
- Place of Presentation
  Kawagoe Prince Hotel
- Data Source
  KAKENHI-PROJECT-23500501
[Presentation] Non-telomeric stem cell aging in hematopoietic regeneration2012
- Author(s)
  Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23500501
[Presentation] 酸化的DNA損傷はヒト造血幹細胞の自己複製能を制限する2012
- Author(s)
  八幡　崇
- Organizer
  第２９回臨床フリーラジカル会議
- Place of Presentation
  京都府
- Invited
- Data Source
  KAKENHI-PROJECT-24590361
[Presentation] Humanized in vivo APL model using human cord blood initiate by induction of PML-RARA.2012
- Author(s)
  Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Satou T, Tanaka M, Hayashi H, Miyachi H, Ando K
- Organizer
  The 3rd JSH International Symposium 2012 in Kawagoe
- Place of Presentation
  埼玉県川越市
- Data Source
  KAKENHI-PROJECT-24591411
[Presentation] APL mice model using PML-RARA-transduced CD34-positive hematopoietic cells from human cord blood2011
- Author(s)
  Hiromichi Matsushita, Takashi Yahata, Yoshihiko Nakamura, Yin Sheng, Yukari Muguruma, Hideyuki Matsuzawa Tomoko Uno, Tomomi Takanashi, Tadayuki Sato, Masayuki Tanaka, Hideki Hayashi, Makoto Onizuka, Yoshiaki Ogawa, Hayato Miyachi, Kiyoshi Ando
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-22790299
[Presentation] Activation of Fibrinolytic Pathway Using a Novel Small Molecule Enhanced Hematopoietic Regeneration2011
- Author(s)
  Abd Aziz Ibrahim, Takashi Yahata, Tomomi Takanashi, Toshio Miyata, and Kiyoshi Ando
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22790299
[Presentation] CD34+/CD38+cells from human cord blood initiate APL by induction of PML-RARA2011
- Author(s)
  Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Satou T, Tanaka M, Hayashi H, Miyachi H, Ando K
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591224
[Presentation] CD34+/CD38+ cells from human cord blood initiate APL by induction of PML-RARA2011
- Author(s)
  Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Ando K
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23500501
[Presentation] CD34+/CD38+ cells from human cord blood initiate APL by induction of PML-RARA2011
- Author(s)
  Matsushita H, Yahata T, Nakamura Y, Sheng Y, Muguruma Y, Matsuzawa H, Uno T, Takanashi T, Satou T, Tanaka M, Hayashi H, Miyachi H, Ando K
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-21591224
[Presentation] DNA損傷の蓄積がヒト造血幹細胞の再生能力を低下させる2010
- Author(s)
  八幡崇
- Organizer
  日本サイトメトリー学会
- Place of Presentation
  東京慈恵医科大学(東京都)
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22790299
[Presentation] Notch signals regulated hematopoietic homeostasis through osteoblastic niche maintenance.2010
- Author(s)
  六車ゆかり、八幡崇、弓野静、盛音、穂積勝人、安藤潔
- Organizer
  第72回日本血液学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] 骨芽細胞におけるDelta-like ligand1の発現が骨代謝維持に重要である2010
- Author(s)
  六車ゆかり、八幡崇、穂積勝人、安藤潔
- Organizer
  第28回日本骨代謝学会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] DNA損傷の蓄積はヒト造血幹細胞の自己複製能を制限する2010
- Author(s)
  八幡崇
- Organizer
  日本血液学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790299
[Presentation] Notch signals regulate hematopoietic homeostasis through osteoblastic niche maintenance2010
- Author(s)
  Yukari Muguruma, Takashi Yahata, Shizu Yumino, Yin Sheng, Katsuto Hozumi, Kiyoshi Ando
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  神奈川(パシフィコ横浜)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790299
[Presentation] DNA損傷の蓄積はヒト造血幹細胞の自己複製能を制限する2010
- Author(s)
  八幡崇
- Organizer
  日本血液学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22220007
[Presentation] DNA損傷の蓄積がヒト造血幹細胞の再生能力を低下させる2010
- Author(s)
  八幡崇
- Organizer
  日本サイトメトリー学会
- Place of Presentation
  東京慈恵医科大学(東京都)
- Year and Date
  2010-06-26
- Data Source
  KAKENHI-PROJECT-22220007
[Presentation] Accumulation of DNA-damage limits the self-renewal capacity of human hematopoietic stem cells2010
- Author(s)
  Takashi Yahata, Tomomi Takanashi, Hideyuki Matsuzawa, Yin Sheng, Tomoko Uno, Makoto Onizuka, Shunichi Kato, Kiyoshi Ando
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  神奈川(パシフィコ横浜)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790299
[Presentation] ヒト造血幹細胞の造血再生の動態と老化2009
- Author(s)
  八幡崇, 他
- Organizer
  日本再生医療学会
- Place of Presentation
  東京
- Year and Date
  2009-03-05
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009
- Author(s)
  八幡崇、高梨朋美、盛音、宇野トモ子、六車ゆかり, 他
- Organizer
  第71回日本血液学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] Importance of Notch signals in hematopoietic homeostasis.2009
- Author(s)
  Muguruma Y, Yahata T, Yumino S, et al.
- Organizer
  The 26th Naito Conference on Osteobiology
- Place of Presentation
  Awaji, Japan
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009
- Author(s)
  八幡崇, 他
- Organizer
  日本血液学会
- Place of Presentation
  京都
- Year and Date
  2009-10-11
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009
- Author(s)
  八幡崇, 他
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会議場(京都)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] Importance of Notch signals in hematopoietic homeostasis.2009
- Author(s)
  Muguruma Y, Yahata T, Sheng Y, et al.
- Organizer
  The 7th Stem Cell Research Symposium
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] Importance of Notch signals in hematopoietic homeostasis2009
- Author(s)
  六車ゆかり、八幡崇
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会議場(京都)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] Importance of Notch signals in maintaining hematopoietic homeostasis.2009
- Author(s)
  六車ゆかり、八幡崇
- Organizer
  内藤カンファレンスosteobiology
- Place of Presentation
  夢舞台(淡路)
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] ヒト造血幹細胞の造血再生の動態と老化2009
- Author(s)
  八幡崇
- Organizer
  第8回日本再生医療学会総会
- Place of Presentation
  東京
- Year and Date
  2009-03-06
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] DNA損傷の蓄積によるヒト造血幹細胞の自己複製能の低下2009
- Author(s)
  八幡崇, 六車ゆかり
- Organizer
  日本血液学会
- Place of Presentation
  国際会議場(京都)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] Importance of Notch signaling in maintaining hematopoietic homeostasis.2009
- Author(s)
  Muguruma Y, Yahata Y, Sheng Y, et al.
- Organizer
  第71回日本血液学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] FACSを用いたヒト造血幹細胞の生体内における性状解析2008
- Author(s)
  八幡崇, 他
- Organizer
  日本サイトメトリー学会
- Place of Presentation
  東京
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] 骨髄造血微小環境の恒常性維持におけるJagged-1分子の重要性2008
- Author(s)
  八幡崇, 他
- Organizer
  日本血液学会
- Place of Presentation
  京都国際会館
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] FACSを用いたヒト造血幹細胞の生体内における性状解析2008
- Author(s)
  八幡崇、他
- Organizer
  第18回日本サイトメトリー学会学術集会
- Place of Presentation
  東京
- Year and Date
  2008-06-28
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] 骨髄造血微小環境の恒常性維持におけるJagged1分子の重要性2008
- Author(s)
  八幡崇、他
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20790238
[Presentation] 骨髄造血微小環境の恒常性維持におけるJagged-1分子の重要性2008
- Author(s)
  八幡崇、六車ゆかり, 他
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-20590289
[Presentation] Interaction between human hematopoietic stem cells and bone marrow hematopoietic microenvironment2007
- Author(s)
  Yahata, T, et. al.
- Organizer
  Japanese Society of Hematology Meeting
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500332
[Presentation] ヒト造血幹細胞と骨髄内造血微小環境の相互作用2007
- Author(s)
  八幡崇, 他
- Organizer
  日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18500332
[Presentation] Interaction between human hematopoietic stem cells andbone marrow Japanease Society of HematologyMeeting2007
- Author(s)
  Yahata, T, et. al.
- Organizer
  Oct HematologyHemtopoieticmicroenvironment
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390285
[Presentation] Human hematopoietic stem cell hierarchy in bone marrow hematopoietic microenvironment2007
- Author(s)
  Yahata, T, et. al.
- Organizer
  Stem cell symposium
- Place of Presentation
  Awajishima
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500332
[Presentation] Interactiion betweeromentn human hematopoietic stem cells and bone marrow hematopoietic microemviroment2007
- Author(s)
  Yahata T, et. al.
- Organizer
  Japanease Society of Hematology Meeting
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500332
[Presentation] In vivo analysis of PML-RARA in a humanized mouse model
- Author(s)
  Matsushita H, Yahata T, Sheng Y, Nakamura Y, Muguruma Y, Matsuzawa H, Tanaka M, Hayashi H, Sato T, Damdinsuren A, Onizuka M, Ito M, Miyachi H, Pandolfi PP, Ando K
- Organizer
  56th ASH Annual Meeting & Exposition
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-24591411
[Presentation] CD34+/CD38+cells from human cord blood initiate APL by induction of PML-RARA
- Author(s)
  Hiromichi Matsushita, Takashi Yahata, Yoshihiko Nakamura, Yin Sheng, Yukari Muguruma, Hideyuki MAtsuzawa, Tomoko Uno, Tomomi Takanashi, Kiyoshi Ando
- Organizer
  日本血液学会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23500501
[Presentation] Jagged1-Notch signal supports human myeloma cell survival
- Author(s)
  Yukari Muguruma, Takashi Yahata, Mamoru Itoh, Katsuto Hozumi, Mika Yamaguchi, Kiyoshi Ando
- Organizer
  日本血液学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26430094
[Presentation] In Vivo Analysis of PML-RARA in a Humanized Mouse Model
- Author(s)
  Hiromichi Matsushita, Takashi Yahata,, Yin Sheng, Yoshihiko Nakamura, Yukari Muguruma, Hideyuki Matsuzawa, Masayuki Tanaka, Hideki Hayashi, Tadayuki Sato, Anar Damdinsuren, Makoto Onizuka, Mamoru Ito, Hayato Miyachi,, Pier Paolo Pandolfi, Kiyoshi Ando
- Organizer
  America Society of Hematology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26430094

1. ANDO Kiyoshi (70176014)

# of Collaborated Projects: 16 results

# of Collaborated Products: 61 results
2. NAKAYAMA Yukari (80398750)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
3. IBRAHIM Abd Aziz (50738789)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
4. HOZUMI Katsuto (30246079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. MATSUSHITA Hiromichi (50286481)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
6. MIYATA Toshio (10222332)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. Ohtsuka Masato (90372945)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ITO Mamoru (00176364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. KOYANAGI Yoshio (80215417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAMETANI Yoshie (50338787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. TAKAHASI Takeshi (80335215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKAHATA Tatsutoshi (20110744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SUEMIZU Hiroshi (40332209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. ETO Tomoo (30370175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIRAYAMA Noriaki (70238393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ONIZUKA Makoto (80366012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 石井恭正 (20548680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 藤村卓 (50396496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 渡邊伸央 (80396928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 増田治史 (50278496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ITO Ryoji

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
22. KATANO Ikumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 遠藤裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 中村雅登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 川田浩志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 鈴木利貴央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 井上大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 犬飼岳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 赤羽弘資

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 原間大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 今井仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAHATA TAKASHI 八幡 崇

YAHATA Takashi 八幡 崇

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Establishment of novel combination cancer immunotherapy targeting regulators of the fibrinolytic systemPrincipal Investigator

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Blockade of PAI-1 eliminates leukemic stem cellsPrincipal Investigator

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Establishment of hematopoietic regeneration by the novel molecular targeting drugPrincipal Investigator

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DNA damage response in human hematopoietic stem cellPrincipal Investigator

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YAHATA TAKASHI 八幡崇

YAHATA Takashi 八幡崇