SAKAI DAISUKE 酒井大輔

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SAKAI Daisuke 酒井大輔

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Researcher Number	10408007
Affiliation (Current)	2025: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2024: 東海大学, 医学部, 教授 2012 – 2023: 東海大学, 医学部, 准教授 2008 – 2011: Tokai University, 医学部, 講師 2010: 東海大学, 外科学系整形外科, 講師 2007: Tokai University, SCHOOL OF MEDICINE, FELLOW 2006 – 2007: 東海大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Basic Section 56070:Plastic and reconstructive surgery-related
Keywords	Principal Investigator 椎間板 / 再生医療 / 再生医学 / 髄核細胞 / 幹細胞 / 脊椎脊髄病学 / 腰痛 / 椎間板変性 / 整形外科学 / リプログラミング … More / 細胞移植 / 凍結保存 / 椎間板再生 / ニッチ / 脊椎 / 培養法 / 創薬 / iPS細胞技術 / 同種細胞移植 / 移植・再生医療 / iPS細胞 / インシリコ創薬 / iPS技術 / 転写因子 / 線維輪細胞 / 線維輪 / 前駆細胞 / 脊椎外科 / 間葉系幹細胞 … More Except Principal Investigator 椎間板変性 / 創薬 / IL-17 / 椎間板 / インシリコ創薬 / Wntシグナル / 腰痛 / 骨髄間葉系幹細胞 / 髄核細胞 / 創傷治癒 / 表皮角化細胞 / Tie2 / Angiopoietin-1 / 難治性皮膚潰瘍 / シグナル伝達 / 酸化ストレス / 低分子化合物 / インターロイキン17 / 腰痛治療薬 / 転写制御 / ＮＧＦ / 神経栄養因子 / Ｗｎｔシグナル / Cell signaling / 腰痛の解明 / ＣＣＮ　family / CCL20 / CCR6 / CCN family / NGF / 炎症性サイトカイン / ケモカイン / 分子学的研究 / mesenchymal stem cell / nucleus pulposus cell / disc regeneration / regenerative medicine / cell transplantation therapy / 臨床応用 / 共培養法 / 間葉系幹細胞 / 椎間板再生 / 再生医療 / 細胞移植療法 / ＥＰ受容体 / Ｗｎｔｼｸﾞﾅﾙ / ﾌﾟﾛｽﾀﾉｲﾄﾞ / NF-κβ / 椎間板細胞 / EP受容体 / 分子学的解析 / TNF－α / PGE2 / Wnt シグナル / 国際情報交換、ドイツ / 国際情報交換、スイス / 国際研究者交流、香港 / フレキシブル / 配向 / ｺﾗｰｹﾞﾝ繊維 / 細胞骨格 / CD146 / ソーティング / 表面マーカー / 線維輪細胞 / 椎間板線維輪 / ｺﾗｰｹﾞﾝｹﾞﾙ収縮 / 細胞表面マーカー / 前駆細胞 / 線維輪培養細胞 / 線維輪組織再構築 / 椎間板再生医療 / カルシウムシグナル / TonEBP / Intervertebral disc / NFAT / BMP2 / TGF-β / intervertebral disc / GlcAT-I / 脊椎脊髄病学 / 安全性 / 凍結保存法 / 活性化髄核細胞 / 変性抑制 / 椎間板移植 / 凍結保存 Less

Development of of intervertebral disc regeneration technology using reprogramming, organoids, exosomes, and genome editingPrincipal Investigator
- Principal Investigator
  
  酒井大輔
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokai University
椎間板変性に対する新規治療法開発へ向けたBag-1の抗酸化ストレス作用の解明
- Principal Investigator
  
  隅山香織
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokai University
Study of the Tie2/Ang-1 system in epidermal keratinocytes and its application
- Principal Investigator
  
  根本仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Tokai University
The investigation of the new small molecule inhibitors of IL-17A for intervertebral disc disease treatment by In Silico analysis
- Principal Investigator
  
  隅山香織
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokai University
Basic development for reprogramming methods and translation of regenerative medicine in intervertebral disc cellsPrincipal Investigator
- Principal Investigator
  
  Sakai Daisuke
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokai University
Analysis of transcription factors mediated by Wnt signal in intervertebral disc degeneration and search for therapeutic agents for low back pain
- Principal Investigator
  
  HIYAMA Akihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Effects of IL-17 on intervertebral disc degeneration and the investigation of the new small-molecule IL-17 inhibitor for treating degenerative discs
- Principal Investigator
  
  SUYAMA Kaori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technologyPrincipal Investigator
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Analysis of molecular mechanism of Wnt signal and arachidonic acid cascade in intervertebral disc degeneration
- Principal Investigator
  
  HIYAMA Akihiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Isolation and application of progenitor cells from annulus fibrosus of the intervertebral disc
- Principal Investigator
  
  NAKAI Tomoko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Analysis of appropriate cell source for efficient annulus fibrosis regenerationPrincipal Investigator
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Identifying the origin and niche environment of nucleus pulposus progenitor cells of the intervertebral disc and its therapeutic applicationsPrincipal Investigator
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Molecular mechanisms involved in intervertebraldisc degeneration and potential new treatment strategies
- Principal Investigator
  
  HIYAMA Akihiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Disc repair with transplantation of activated nucleus pulposus cells-how to preserve the cells and its safety-
- Principal Investigator
  
  MOCHIDA Joji, MOCHIDA Joji
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
Identification of endogenous stem cells of the intervertebral disc in degeneration and treatment applicationsPrincipal Investigator
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
椎間板再生医療における基礎的研究:推間板細胞解析と幹細胞からの分化誘導実験Principal Investigator
- Principal Investigator
  
  酒井大輔
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University
DISC REPAIR WITH HUMAN CELL, THERAPYINFLUENCED BY MESENCHYMAL STEM CELLS
- Principal Investigator
  
  MOCHIDA Joji
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokai University

[Journal Article] SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential.2024
- Author(s)
  Tamagawa, S., Sakai, D., Nojiri, H., Nakamura, Y., Warita, T., Matsushita, E., Schol, J., Soma, H., Ogasawara, S., Munesada, D., Koike, M., Shimizu, T., Sato, M., Ishijima, M., Watanabe, M.
- Journal Title
  
  Redox Biol
  
  Volume: 71 Pages: 103091-103091
- DOI
  10.1016/j.redox.2024.103091
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19607, KAKENHI-PROJECT-20H03809
[Journal Article] ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain2024
- Author(s)
  Ambrosio Luca、Schol Jordy、Ruiz-Fernandez Clara、Tamagawa Shota、Soma Hazuki、Tilotta Veronica、Di Giacomo Giuseppina、Cicione Claudia、Nakayama Shunya、Kamiya Kosuke、Papalia Rocco、Sato Masato、Vadala Gianluca、Watanabe Masahiko、Denaro Vincenzo、Sakai Daisuke
- Journal Title
  
  European Spine Journal
  
  Volume: - Issue: 5 Pages: 1713-1727
- DOI
  10.1007/s00586-024-08163-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] Nuclear Factor-κB Decoy Oligodeoxynucleotide Attenuates Cartilage Resorption In Vitro2024
- Author(s)
  Nemoto Hitoshi、Sakai Daisuke、Watson Deborah、Masuda Koichi
- Journal Title
  
  Bioengineering
  
  Volume: 11 Issue: 1 Pages: 46-46
- DOI
  10.3390/bioengineering11010046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] Monomeric CRP regulates inflammatory responses in human intervertebral disc cells2023
- Author(s)
  Ruiz-Fernandez Clara、Ait Eldjoudi Djedjiga、Gonzalez-Rodriguez Maria、Cordero Barreal Alfonso、Farrag Yousof、GarcIa-Caballero Lucia、Lago Francisca、Mobasheri Ali、Sakai Daisuke、Pino Jesus、Gualillo Oreste
- Journal Title
  
  Bone & Joint Research
  
  Volume: 12 Issue: 3 Pages: 189-198
- DOI
  10.1302/2046-3758.123.bjr-2022-0223.r1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] Investigation of the Mitigation of DMSO-Induced Cytotoxicity by Hyaluronic Acid following Cryopreservation of Human Nucleus Pulposus Cells2023
- Author(s)
  Munesada Daiki、Sakai Daisuke、Nakamura Yoshihiko、Schol Jordy、Matsushita Erika、Tamagawa Shota、Sako Kosuke、Ogasawara Shota、Sato Masato、Watanabe Masahiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 15 Pages: 12289-12289
- DOI
  10.3390/ijms241512289
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] Comprehensive narrative review on the analysis of outcomes from cell transplantation clinical trials for discogenic low back pain2023
- Author(s)
  Schol J, Sakai D
- Journal Title
  
  N Am Spine Soc J .
  
  Volume: 13 Pages: 100195-100195
- DOI
  10.1016/j.xnsj.2022.100195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] Recombinant Laminin-511 Fragment (iMatrix-511) Coating Supports Maintenance of Human Nucleus Pulposus Progenitor Cells In Vitro2023
- Author(s)
  Soma Hazuki、Sakai Daisuke、Nakamura Yoshihiko、Tamagawa Shota、Warita Takayuki、Schol Jordy、Matsushita Erika、Naiki Mitsuru、Sato Masato、Watanabe Masahiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 23 Pages: 16713-16713
- DOI
  10.3390/ijms242316713
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] N-acetylcysteine attenuates oxidative stress-mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production.2022
- Author(s)
  Tamagawa S, Sakai D, Schol J
- Journal Title
  
  JOR Spine
  
  Volume: 5 Issue: 4 Pages: 863-863
- DOI
  10.1002/jsp2.1223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review2022
- Author(s)
  Kaori Suyama, Daisuke Sakai , Masahiko Watanabe
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10
- DOI
  10.3389/fcell.2022.857164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09490
[Journal Article] Morphological and biomechanical effects of annulus fibrosus injury and repair in an ovine cervical model2020
- Author(s)
  Long Rose G.、Ferguson Stephen J.、Benneker Lorin M.、Sakai Daisuke、Li Zhen、Pandit Abhay、Grijpma Dirk W.、Eglin David、Zeiter Stephan、Schmid Tanja、Eberli Ursula、Nehrbass Dirk、Di Pauli von Treuheim Theodor、Alini Mauro、Iatridis James C.、Grad Sibylle
- Journal Title
  
  JOR SPINE
  
  Volume: 3 Issue: 1
- DOI
  10.1002/jsp2.1074
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review.2020
- Author(s)
  Volleman TNE, Schol J, Morita K, Sakai D, Watanabe M.
- Journal Title
  
  Neurospine
  
  Volume: 1 Issue: 1 Pages: 19-35
- DOI
  10.14245/ns.2040040.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03809
[Journal Article] Annulus fibrosus cell sheets limit disc degeneration in a rat annulus fibrosus injury model2019
- Author(s)
  Nukaga Tadashi、Sakai Daisuke、Schol Jordy、Sato Masato、Watanabe Masahiko
- Journal Title
  
  JOR SPINE
  
  Volume: 2 Issue: 2
- DOI
  10.1002/jsp2.1050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] IVD progenitor cells: a new horizon for understanding disc homeostasis and repair2019
- Author(s)
  Lyu Feng-Juan、Cheung Kenneth M.、Zheng Zhaomin、Wang Hua、Sakai Daisuke、Leung Victor Y.
- Journal Title
  
  Nature Reviews Rheumatology
  
  Volume: 15 Issue: 2 Pages: 102-112
- DOI
  10.1038/s41584-018-0154-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Cell therapy for intervertebral disc herniation and degenerative disc disease: clinical trials2019
- Author(s)
  Jordy Schol、Daisuke Sakai
- Journal Title
  
  International Orthopaedics
  
  Volume: 43 Issue: 4 Pages: 1011-1025
- DOI
  10.1007/s00264-018-4223-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro2019
- Author(s)
  Nukaga Tadashi、Sakai Daisuke、Schol Jordy、Suyama Kaori、Nakai Tomoko、Hiyama Akihiko、Watanabe Masahiko
- Journal Title
  
  Spine Surgery and Related Research
  
  Volume: 3 Issue: 4 Pages: 385-391
- DOI
  10.22603/ssrr.2019-0019
- NAID
  130007734403
- ISSN
  2432-261X
- Year and Date
  2019-10-27
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response2019
- Author(s)
  Wangler Sebastian、Peroglio Marianna、Menzel Ursula、Benneker Lorin M.、Haglund Lisbet、Sakai Daisuke、Alini Mauro、Grad Sibylle
- Journal Title
  
  SPINE
  
  Volume: 44 Issue: 23 Pages: 1613-1622
- DOI
  10.1097/brs.0000000000003150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods2019
- Author(s)
  Frauchiger Daniela A.、Tekari Adel、May Rahel D.、D?afo Emina、Chan Samantha C.W.、Stoyanov Jivko、Bertolo Alessandro、Zhang Xingshuo、Guerrero Julien、Sakai Daisuke、Schol Jordy、Grad Sibylle、Tryfonidou Marianna、Benneker Lorin M.、Gantenbein Benjamin
- Journal Title
  
  Tissue Engineering Part C: Methods
  
  Volume: 25 Issue: 10 Pages: 571-580
- DOI
  10.1089/ten.tec.2018.0375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration2018
- Author(s)
  Zhou Zhiyu、Zeiter Stephan、Schmid Tanja、Sakai Daisuke、Iatridis James C.、Zhou Guangqian、Richards R. Geoff、Alini Mauro、Grad Sibylle、Li Zhen
- Journal Title
  
  CARTILAGE
  
  Volume: - Issue: 2 Pages: 169-180
- DOI
  10.1177/1947603518764263
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease.2018
- Author(s)
  Kaori Suyama, Daisuke Sakai, Noriaki Hirayama, Yoshihiko Nakamura, Erika Matsushita, Hayato Terayama, Ning Qu, Osamu Tanaka, Kou Sakabe, Masahiko Watanabe
- Journal Title
  
  Journal of Cellular and Molecular Medicine
  
  Volume: Nov;22 Issue: 11 Pages: 5539-5551
- DOI
  10.1111/jcmm.13828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10946, KAKENHI-PROJECT-18K10031, KAKENHI-PROJECT-16H05456
[Journal Article] Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury2018
- Author(s)
  Mohd Isa Isma Liza、Abbah Sunny A.、Kilcoyne Michelle、Sakai Daisuke、Dockery Peter、Finn David P.、Pandit Abhay
- Journal Title
  
  Science Advances
  
  Volume: 4 Issue: 4
- DOI
  10.1126/sciadv.aaq0597
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Histological and reference system for the analysis of mouse intervertebral disc2017
- Author(s)
  Tam Vivian、Chan Wilson C.W.、Leung Victor Y.L.、Cheah Kathryn S.E.、Cheung Kenneth M.C.、Sakai Daisuke、McCann Matthew R.、Bedore Jake、S?guin Cheryle A.、Chan Danny
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: 36 Issue: 1 Pages: 233-243
- DOI
  10.1002/jor.23637
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Regenerative technologies to bed side: Evolving the regulatory framework2017
- Author(s)
  Sakai Daisuke、Schol Jordy、Foldager Casper B.、Sato Masato、Watanabe Masahiko
- Journal Title
  
  Journal of Orthopaedic Translation
  
  Volume: 9 Pages: 1-7
- DOI
  10.1016/j.jot.2017.02.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Animal models for studying the etiology and treatment of low back pain2017
- Author(s)
  Shi Changgui、Qiu Sujun、Riester Scott M.、Das Vaskar、Zhu Bingqian、Wallace Atiyayein A.、van Wijnen Andre J.、Mwale Fackson、Iatridis James C.、Sakai Daisuke、Votta-Velis Gina、Yuan Wen、Im Hee-Jeong
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: - Issue: 5 Pages: 1305-1312
- DOI
  10.1002/jor.23741
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells2016
- Author(s)
  Tekari A, Chan SCW, Sakai D, Grad S, Gantenbein B
- Journal Title
  
  Stem Cell Research and therapy
  
  Volume: 7 Issue: 1 Pages: 75-75
- DOI
  10.1186/s13287-016-0337-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] CD146 defines commitment of cultured annulus fibrosus cells to express a contractile phenotype2016
- Author(s)
  Nakai T, Sakai D, Nakamura Y, Nukaga T, Grad S, Li Z, Alini M, Chan D, Mausda K, Ando K, Watanabe M
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: 34 Issue: 8 Pages: 1361-72
- DOI
  10.1002/jor.23326
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Journal Article] Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.2016
- Author(s)
  Rho Nakamichi, Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz M, Sakai D, Masuda K, Ozaki T, Asahara H.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 12503-12503
- DOI
  10.1038/ncomms12503
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01486, KAKENHI-PLANNED-26113008, KAKENHI-PROJECT-15K15387, KAKENHI-PROJECT-15K15544, KAKENHI-INTERNATIONAL-15K21720, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-16H05456
[Journal Article] Migration of bone marrow-derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study2015
- Author(s)
  Sakai D, Nishimura K, Tanaka M, Nakajima D, Grad S, Alini M, Kawada H, Ando K, Mochida J
- Journal Title
  
  Spine Journal
  
  Volume: 15 Issue: 6 Pages: 1356-1365
- DOI
  10.1016/j.spinee.2013.07.491
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] Advancing the cellular and molecular therapy for intervertebral disc disease.2015
- Author(s)
  Sakai D, Grad S
- Journal Title
  
  Advanced Drug Delivery Reviews
  
  Volume: 未定 Pages: 159-171
- DOI
  10.1016/j.addr.2014.06.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] Stem cell therapy for intervertebral disc regeneration: obstacles and solutions2015
- Author(s)
  Sakai D, Andersson GBJ
- Journal Title
  
  Nature Reviews Rheumatology
  
  Volume: 11 Issue: 4 Pages: 243-256
- DOI
  10.1038/nrrheum.2015.13
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] 【脊椎脊髄の科学-基礎と臨床の進歩Review 2014】 (第1章)基礎科学　椎間板再生の現況と問題点2014
- Author(s)
  酒井大輔、持田讓治
- Journal Title
  
  脊椎脊髄ジャーナル
  
  Volume: 27 Pages: 239-246
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] 運動器再生医療研究の最先端椎間板再生の今2014
- Author(s)
  酒井大輔、持田讓治
- Journal Title
  
  日本整形外科学会雑誌
  
  Volume: 88 Pages: 216-223
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture2014
- Author(s)
  Pattappa G, Peroglio M, Sakai D, Mochida J, Benneker LM, Alini M, Grad S
- Journal Title
  
  European Cells and Materials
  
  Volume: 27 Pages: 124-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells2013
- Author(s)
  Yokoyama K1, Hiyama A, Arai F, Nukaga T, Sakai D, Mochida J
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 9 Pages: e73210-e73210
- DOI
  10.1371/journal.pone.0073210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] Cell Signaling Pathways Related to Pain Receptors in the Degenerated Disk2013
- Author(s)
  Hiyama A, Sakai D, Mochida J
- Journal Title
  
  Global Spine Journal
  
  Volume: 3 Pages: 165-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] Effect of cryopreservation on canine and human activated nucleus pulposus cells: a feasibility study for cell therapy of the intervertebral disc.2013
- Author(s)
  田中真弘、酒井大輔、檜山明彦、新井文征、中島大輔、額賀唯至、中井知子、持田譲治
- Journal Title
  
  BioResearch
  
  Volume: 2 Issue: 4 Pages: 273-282
- DOI
  10.1089/biores.2013.0023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592212
[Journal Article] The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.2012
- Author(s)
  Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J.
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 14 Issue: 3
- DOI
  10.1186/ar3830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592213
[Journal Article] The expression and role of non-canonical(PKC) signaling in nucleus pulposus cell metabolism2012
- Author(s)
  Arai F, Hiyama A, Sakai D, Yokoyama K, Mochida J
- Journal Title
  
  J Orthop Res
  
  Volume: 30(In press) Issue: 9 Pages: 1478-85
- DOI
  10.1002/jor.22095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406, KAKENHI-PROJECT-24592213
[Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012
- Author(s)
  Abe, K. et al.
- Journal Title
  
  Genesis
  
  Volume: 50 Issue: 10 Pages: 758-765
- DOI
  10.1002/dvg.22035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-22500392, KAKENHI-PROJECT-22791388, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23592892, KAKENHI-PROJECT-23593038, KAKENHI-PROJECT-23700562, KAKENHI-PROJECT-24580411, KAKENHI-PROJECT-24592213, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-24115712
[Journal Article] Homing of mesenchymal stem cells in induced degenerative intervertebral discs in a whole organ culture system2012
- Author(s)
  Illien-Junger S, Sakai D, et al
- Journal Title
  
  Spine
  
  Volume: 37(In press) Issue: 22 Pages: 1865-1873
- DOI
  10.1097/brs.0b013e3182544a8a
- NAID
  10031169857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406, KAKENHI-PROJECT-24592213
[Journal Article] Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc.2012
- Author(s)
  Sakai, D. et al.
- Journal Title
  
  Nature Comm.
  
  Volume: 3 Issue: 1 Pages: 1264-1264
- DOI
  10.1038/ncomms2226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-24390248, KAKENHI-PROJECT-24592212, KAKENHI-PROJECT-24592213
[Journal Article] Effects of a glycogen synthase kinase 3β inhibitor(LiCl) on c-myc protein in intervertebral disc cells2011
- Author(s)
  Hiyama A, Sakai D, Arai F, Nakajima D, Yokoyama K, Mochida J
- Journal Title
  
  J Cell Biochem
  
  Volume: 112(10) Pages: 2974-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Stem cell regeneration of the intervertebral disk2011
- Author(s)
  Sakai D
- Journal Title
  
  Orthop Clin North Am
  
  Volume: 42(4) Pages: 555-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Hypoxia activates the notch signaling pathway in cells of the intervertebral disc : implications in degenerative disc disease2011
- Author(s)
  Hiyama A, Skubutyte R, Markova D, Anderson DG, Yadla S, Sakai D, Mochida J, Albert TJ, Shapiro IM, Risbud MV
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 1355-1364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell2010
- Author(s)
  Hiyama A, Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, Mochida J
- Journal Title
  
  J Cell Physiol
  
  Volume: 226 Pages: 1139-1148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Primary immune system responders to nucleus pulposus cells : evidence for immune response in disc herniation2010
- Author(s)
  Murai K, Sakai D, Nakamura Y, Nakai T, Igarashi T, Seo N, Murakami T, Kobayashi E, Mochida J
- Journal Title
  
  Eur Cell Mater
  
  Volume: 19 Pages: 13-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells.2010
- Author(s)
  Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J.
- Journal Title
  
  Journal of Orthopaedic Research Vol 28
  
  Pages: 623-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390405
[Journal Article] Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model2010
- Author(s)
  Serigano K, Sakai D, Hiyama A, Tamura F, Tanaka M, Mochida J
- Journal Title
  
  J Orthop Res
  
  Volume: 28 Pages: 1267-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Enhanced intervertebral disc cells senescence by Wnt/beta-catenin signaling-induced matrix metalloproteinase expression2010
- Author(s)
  Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, Abe K, Mochida J
- Journal Title
  
  Arthritis Rheum
  
  Volume: 62 Pages: 3036-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Variations in gene and protein expression in human nucleus pulposus in comparisonwith annulus fibrosus and cartilage cells: potential associations with aging and degeneration.2010
- Author(s)
  Rutges J, Creemers LB, Dhert W, Milz S, Sakai D, Mochida J, Alini M, Grad S
- Journal Title
  
  Osteoarthritis Cartilage. 18(3)
  
  Pages: 416-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells2010
- Author(s)
  Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J
- Journal Title
  
  J Orthop Res
  
  Volume: 28 Pages: 623-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells2010
- Author(s)
  Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: Vol.28 Pages: 623-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390405
[Journal Article] Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model2010
- Author(s)
  Serigano K, Sakai D, et al.
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: 28 Pages: 1267-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells2010
- Author(s)
  Watanabe T, Sakai D, et al.
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: 28 Pages: 623-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression.2010
- Author(s)
  Hiyama A, Sakai D, et al.
- Journal Title
  
  Arthritis Rheumatism
  
  Volume: 62 Pages: 3036-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791406
[Journal Article] Primary immune system responders to nucleus pulposus cells: evidence for immune response in disc herniation.2010
- Author(s)
  Murai K, Sakai D, Nakamura Y, Nakai T, Igarashi T, Seo N, Murakami T, Kobayashi E, Mochida J
- Journal Title
  
  Eur Cell Mater. 19
  
  Pages: 13-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] Activation of TonEBP by calcium controls {beta}1, 3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.2009
- Author(s)
  Hiyama A, Gajghate S, Sakai D, Mochida J, Shapiro IM, Risbud MV
- Journal Title
  
  J Biol Chem. 284(15)
  
  Pages: 9824-9834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus.2009
- Author(s)
  Sakai D, Nakai T, Mochida J, Alini M, Grad S
- Journal Title
  
  Spine 34(14)
  
  Pages: 1448-1456
- NAID
  10027244193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells2009
- Author(s)
  Watanabe T, Sakai D, YamamotoY, Iwashina T, Serigano K, Tamura F, Mochida J
- Journal Title
  
  J Orthop Res. 28
  
  Pages: 623-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390405
[Journal Article] Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc.2009
- Author(s)
  Gajghate S, Hiyama A, Shah M, Sakai D, Anderson DG, Shapiro IM, Risbud MV
- Journal Title
  
  Bone Miner Res. 24(6)
  
  Pages: 992-1001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] Differential phenotype of intervertebral disc cells : microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus2009
- Author(s)
  Sakai D, Nakai T, Mochida J, Alini M, Grad S
- Journal Title
  
  Spine 34
  
  Pages: 1448-1456
- NAID
  10027244193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390405
[Journal Article] Differential phenotype of intervertebral disc cells : microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus2009
- Author(s)
  Sakai, Daisuke
- Journal Title
  
  Spine 34
  
  Pages: 1448-56
- NAID
  10027244193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] 細胞レベルからの椎間板再生 -細胞移植療法のその先に-2009
- Author(s)
  酒井大輔、持田譲治
- Journal Title
  
  日本腰痛学会雑誌第15巻
  
  Pages: 95-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390405
[Journal Article] Low-intensity pulsed ultrasound stimulates cell proliferation, proteoglycan synthesis and expression of growth factor-related genes in human nucleus pulposus cell line.2009
- Author(s)
  Kobayashi Y, Sakai D, Iwashina T, Iwabuchi S, Mochida J
- Journal Title
  
  Eur Cell Mater. 17
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] Transplantation of mesenchymal stem cells in a canine disc degenerative model2008
- Author(s)
  Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Tamura F, Sakai D
- Journal Title
  
  Journal of Orthopaedic Research 26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] stem cell applications in intervertebral discrepair2008
- Author(s)
  檜山明彦, 持田譲治, 酒井大輔
- Journal Title
  
  Cell and Molecular Biology 54
  
  Pages: 24-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390405
[Journal Article] Cross talk between Smad transcription factors and TNF-alpha in intervertebral disc degeneration2008
- Author(s)
  Hiyama, A・Mochida, J・Omi, H・Serigano, K・Sakai, D
- Journal Title
  
  Biochemical Biophysical Research Communications 369(In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Low-intensity pulsed ultrasound stimulation enhances TIMP-1 in nucleus pulposus cells and MCP-1 in macrophages in the rat2008
- Author(s)
  Omi, H・Mochida, J・Iwaskma, T・Katsuno, R・Hiyama, A・Watanabe, T・Serigano, K・Iwabuchi, S・Sakai, D
- Journal Title
  
  Journal of Orthopaedic Research 26(In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Future perspectives of cell-based therapy for intervertebral disc disease2008
- Author(s)
  Sakai, Daisuke
- Journal Title
  
  European Spine Journal 17
  
  Pages: 452-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791056
[Journal Article] Transplantation of mesenchymal stem cells in a canine disc degeneration model2008
- Author(s)
  Hiyama, A・Mochida, J・Iwashina, T・Omi, H・Watanabe, T・Serigano, K・kmura, F・Sakai, D
- Journal Title
  
  Journal of Orthopaedic Research 26(In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Synergistic effect of low-intensity pulsed ultrasound on growth factor stimulation of nucleus pulposus cells2007
- Author(s)
  Hiyama, A・Mochida, J・Omi, H・Serigano, K・Sakai, D
- Journal Title
  
  Journal of Orthopaedic Research 25
  
  Pages: 1574-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Nkx2.2 expression in differentiation of oligodendrocyte precursor cells and inhibitory factors for differentiation of oligodendrocytes afier traumatic spinal cord injury2007
- Author(s)
  Suyama, K・Watanabe, M・Sakai, D・Osada, T・Imai, M・Mochida, J
- Journal Title
  
  Joumal of Neurotrauma 26
  
  Pages: 1013-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] 椎間板再生の現状と展望椎間板髄核、線維輪細胞の識別と間葉系幹細胞からの誘導2007
- Author(s)
  酒井大輔
- Journal Title
  
  日本整形外科学会雑誌 81
  
  Pages: 545-550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Synergic effect of low-intensity pulsed ultrasound on growth factor stimulation of nucleus pulposus cells2007
- Author(s)
  Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K, Iwabuchi S, Sakai D
- Journal Title
  
  Journal of Orthopaedic Research 25
  
  Pages: 1574-1581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 椎間板再生の現状と展望椎間板髄核、線維輪細胞の識別と間葉系幹細胞からの誘導2007
- Author(s)
  酒井大輔、岩品徹、渡邊拓也、檜山明彦、大見博子、持田譲治
- Journal Title
  
  日本整形外科学会雑誌 81
  
  Pages: 545-550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 椎間板再生の現状と展望椎間板髄核,線維輪細胞の識別と間葉系幹細胞からの誘導2007
- Author(s)
  酒井大輔, 岩品徹, 渡邊拓也, 檜山明彦, 大見博子, 持田譲治
- Journal Title
  
  日本整形外科学会雑誌 81
  
  Pages: 545-550
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] A phenotypic comparison of intervertebral disc and articular cartilage oells in the rat2007
- Author(s)
  Lee, CR・Sakai, D・Nakai, T・Toyama, K・Mccbida, J・Alini, M・Grad, S
- Journal Title
  
  European Spine Journal 16
  
  Pages: 2174-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] 腰痛に対する再生医療の現状と展望2007
- Author(s)
  酒井大輔
- Journal Title
  
  Pharma Medica 25
  
  Pages: 51-56
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] 腰椎椎間板ヘルニアの基礎から最先端治療まで椎間板の変性と再生2007
- Author(s)
  酒井大輔, 岩品徹, 渡邊拓也, 桧山明彦, 大見博子, 中井知子, 持田譲治
- Journal Title
  
  整災外 50
  
  Pages: 197-204
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Low-intensity pulsed ultrasound stimulates cell proliferation and proteoglycan production in rabbit intervertebral disc cells cultured in alginate2006
- Author(s)
  Sakai, Daisuke
- Journal Title
  
  Biomaterials 27・1
  
  Pages: 354-361
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Low-intensity pulsed ultrasound stimulates cell proliferation and proteoglycan production in rabbit intervertebral disc cells cultured in alginate2006
- Author(s)
  Iwashina, T, Mochida, J, Miyazaki, T, Watanabe, T, Iwabuchi, S, Ando, K, Hotta, T, Sakai, D
- Journal Title
  
  Biomaterials 27
  
  Pages: 354-361
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Atelocollagen for culture of human nucleus pulposus cells forming nucleus pulposus-like tissue in vitro : influence on the proliferation and proteoglycan production of HNPSV-1 cells2006
- Author(s)
  Sakai, Daisuke
- Journal Title
  
  Biomaterials 27・1
  
  Pages: 346-353
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc2006
- Author(s)
  Sakai, D, Mochida, J, Iwashina, T, Hiyama, A, Omi, H, Imai, M, Nakai, T, Ando, K, Hotta, T
- Journal Title
  
  Biomaterials 27
  
  Pages: 335-345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] ヒト髄核細胞の分化調節におけるCTGFの機能解析2006
- Author(s)
  酒井大輔, 持田譲治他
- Journal Title
  
  日本整形外科学会雑誌 80巻8号
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Feasibility of using a human nucleus pulposus cell line as a cell source in cell transplantation therapy for intervertebral disc degeneration2006
- Author(s)
  Sakai, Daisuke
- Journal Title
  
  Spine 31
  
  Pages: 1177-1186
- NAID
  10020594452
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Expression of CD90 on keratinocyte stem/progenitor cells2006
- Author(s)
  Sakai, Daisuke
- Journal Title
  
  British Journal of Dermatology 154
  
  Pages: 1062-1070
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] 組織工学的手法を用いた人工髄核組織構築の試み2006
- Author(s)
  酒井大輔, 持田譲治他
- Journal Title
  
  日本整形外科学会雑誌 80巻8号
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Atelocollagen for culture of human nucleus pulposus cells forming nucleus pulposus-like tissue in vitro:influence on the proliferation and proteoglycan production of HNPSV-1 cells2006
- Author(s)
  Sakai D, Mochida J, Iwashina T, Watanabe T, Suyama K, Ando K, Hotta T
- Journal Title
  
  Biomaterials 27
  
  Pages: 346-353
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Atelocollagen for culture of human nucleus pulposus cells forming nucleus pulposus-like tissue in vitro : influence on the proliferation and proteoglycan production of HNPSV-1 cells2006
- Author(s)
  Sakai, D, Mochida, J, Iwashina, T, Watanabe, T, Suyama, K, Ando, K, Hotta, T
- Journal Title
  
  Biomaterials 27
  
  Pages: 346-353
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc2006
- Author(s)
  Sakai, Daisuke
- Journal Title
  
  Biomaterials 27・1
  
  Pages: 335-345
- Data Source
  KAKENHI-PROJECT-18791060
[Journal Article] Feasibility of using a human nucleus pulposus cell line as a cell source in cell transplantation therapy for intervertebral disc degeneration2006
- Author(s)
  Iwashina T, Mochida J, Sakai D
- Journal Title
  
  Spine 31
  
  Pages: 1177-1186
- NAID
  10020594452
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc.2006
- Author(s)
  Daisuke Sakai, Joji Mochida et al.
- Journal Title
  
  Biomaterials Vol.27
  
  Pages: 335-345
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Feasibility of using a human nucleus pulposus cell line as a cell source in cell transplantation therapy for intervertebral disc degeneration2006
- Author(s)
  Iwashina, T, Mochida, J, Sakai, D
- Journal Title
  
  Spine 31
  
  Pages: 1177-1186
- NAID
  10020594452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc2006
- Author(s)
  Sakai D, Mochida J, Iwashina T, Hiyama A, Omi H, Imai M, Nakai T, Ando K, Hotta T
- Journal Title
  
  Biomaterials 27
  
  Pages: 335-345
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Low-intensity pulsed ultrasound stimulates cell proliferation and proteoglycan production in rabbit intervertebral disc cells cultured in alginate2006
- Author(s)
  Iwashina T, Mochida J, Miyazaki T, Watanabe T, Iwabuchi S, Ando K, Hotta T, Sakai D
- Journal Title
  
  Biomaterials 27
  
  Pages: 354-361
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 間葉系幹細胞から髄核、線維輪細胞へのin vitroでの誘導系におけるcell-associated matrix、接着分子、表面抗原の解析2005
- Author(s)
  酒井大輔, 持田讓治他
- Journal Title
  
  日本脊椎脊髄病学会雑誌 16巻1号
  
  Pages: 100-100
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model.2005
- Author(s)
  Daisuke Sakai, Joji Mochida et al.
- Journal Title
  
  SPINE Vol.30 No.21
  
  Pages: 2379-2387
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 椎間板髄核、線維輪細胞の識別と間葉系幹細胞からの誘導2005
- Author(s)
  酒井大輔, 持田讓治他
- Journal Title
  
  日本整形外科学会雑誌 79巻8号
- NAID
  10020157807
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model. potential and limitation for stem cell therapy in disc degeneration2005
- Author(s)
  Sakai, D, Mochida, J, Iwashina, T, Watanabe, T, Nakai, T, Ando, K, Hotta, T
- Journal Title
  
  Spine 30
  
  Pages: 2379-2387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model.potential and limitation for stem cell therapy in disc degeneration2005
- Author(s)
  Sakai D, Mochida J, Iwashina T, Watanabe T, Nakai T, Ando K, Hotta T
- Journal Title
  
  Spine 30
  
  Pages: 2379-2387
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 椎間板髄核細胞のマーカー解析-インテグリンα6は髄核特異的に発現する-2005
- Author(s)
  酒井大輔, 持田讓治他
- Journal Title
  
  日本整形外科学会雑誌 79巻8号
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells ; significance of direct cell-to-cell contact in coculture system2004
- Author(s)
  Yamamoto, Y, Mochida, J, Sakai, D, Nakai, T, Nishimura, K, Kawada, H, Hotta, T
- Journal Title
  
  Spine 29
  
  Pages: 1508-1514
- NAID
  10017379543
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Immortalization of human nucles pulposus cells by recombinant SV 40 adenovirus vector:Establishment of a novel cell line for the study of human nucleus pulposus cells2004
- Author(s)
  Sakai D, Mochida J, Yamamoto Y, Toh E, Iwashina T, Miyazaki T, Inokuchi S, Ando K, Hotta T
- Journal Title
  
  Spine 29
  
  Pages: 1515-1523
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 椎間板変性抑制に対する骨髄間葉系幹細胞移植の研究2004
- Author(s)
  酒井大輔他
- Journal Title
  
  臨床整形外科 39巻4号
  
  Pages: 497-502
- NAID
  10010522824
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Immortalization of human nucleus pulposus cells by recombinant SV 40 adenovirus vector : Establishment of a novel cell line for the study of human nucleus pulposus cells2004
- Author(s)
  Sakai, D, Mochida, J, Yamamoto, Y, Toh, E, Iwashina, T, Miyazaki, T, Inokuchi, S, Ando, K, Hotta, T
- Journal Title
  
  Spine 29
  
  Pages: 1515-1523
- NAID
  10017379572
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 幹細胞を用いた細胞移植による椎間板再生2004
- Author(s)
  酒井大輔他
- Journal Title
  
  日本整形外科学会雑誌 78巻12号
  
  Pages: 929-933
- NAID
  10014295013
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] 椎間板変性の分子メカニズムから治療へ幹細胞を用いた細胞移植による椎間板再生2004
- Author(s)
  酒井大輔, 持田譲治, 山本至宏, 野村武
- Journal Title
  
  日整会誌 78
  
  Pages: 929-933
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Journal Article] Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells;significance of direct cell-to-cell contact in coculture system2004
- Author(s)
  Yamamoto Y, Mochida J, Sakai D, Nakai T, Nishimura K, Kawada H, Hotta T
- Journal Title
  
  Spine 29 29
  
  Pages: 1508-1514
- NAID
  10017379543
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16390443
[Patent] 髄核細胞マスターレギュレーター転写因子を含む分化誘導剤、誘導髄核細胞の製造方法、および誘導髄核細胞の用途2022
- Inventor(s)
  酒井大輔、ショール　ジョルディ、平石駿介、升井伸治
- Industrial Property Rights Holder
  学校法人東海大学、国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-502340
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20H03809
[Patent] 髄核細胞マスターレギュレーター転写因子を含む分化誘導剤、誘導髄核細胞の製造方法、および誘導髄核細胞の用途2021
- Inventor(s)
  酒井大輔、ジョルディショール、中村嘉彦
- Industrial Property Rights Holder
  学校法人東海大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-557862
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20H03809
[Patent] Tie2陽性幹/前駆細胞を含む細胞集団の培養方法およびその利用2019
- Inventor(s)
  酒井大輔、中村嘉彦、松下枝利香
- Industrial Property Rights Holder
  学校法人東海大学、日本臓器製薬株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-546051
- Filing Date
  2019
- Acquisition Date
  2020
- Data Source
  KAKENHI-PROJECT-16H05456
[Patent] 髄核細胞マスターレギュレーター転写因子を含む分化誘導剤、誘導髄核細胞の製造方法、および誘導髄核細胞の用途2019
- Inventor(s)
  酒井大輔、ジルディショール、平石駿介、升井伸治
- Industrial Property Rights Holder
  学校法人東海大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-066535
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05456
[Patent] Tie2陽性幹/前駆細胞を含む細胞集団の培養方法およびその利用2019
- Inventor(s)
  酒井大輔、中村嘉彦、松下枝利香
- Industrial Property Rights Holder
  学校法人東海大学、日本臓器製薬株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-16H05456
[Patent] Tie2陽性幹/前駆細胞を含む細胞集団の培養方法およびその利用2019
- Inventor(s)
  酒井大輔、中村嘉彦、松下枝利香
- Industrial Property Rights Holder
  学校法人東海大学、日本臓器製薬株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-163750
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05456
[Patent] IL-17受容体結合部の阻害によるIL-17活性の制御方法2019
- Inventor(s)
  酒井大輔、隅山香織、平山令明
- Industrial Property Rights Holder
  学校法人東海大学、日本臓器製薬株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-030061
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05456
[Patent] IL-17A活性阻害剤およびその用途2019
- Inventor(s)
  酒井大輔、平山令明、隅山香織
- Industrial Property Rights Holder
  酒井大輔、平山令明、隅山香織
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K10946
[Patent] IL-17A活性阻害剤およびその用途2019
- Inventor(s)
  酒井大輔、平山令明、隅山香織
- Industrial Property Rights Holder
  酒井大輔、平山令明、隅山香織
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K10946
[Patent] 髄核マスターレギュレーター転写因子を含む分化転換剤、誘導髄核細胞の製造方法、および誘導髄核細胞の用途2019
- Inventor(s)
  酒井大輔、ジョルディショール、平石駿介、升井伸治
- Industrial Property Rights Holder
  酒井大輔、ジョルディショール、平石駿介、升井伸治
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-066535
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16H05456
[Patent] ＩＬ－１７Ａ活性阻害剤およびその用途2018
- Inventor(s)
  酒井大輔、平山令明、隅山香織
- Industrial Property Rights Holder
  酒井大輔、平山令明、隅山香織
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K10946
[Patent] 椎間板髄核幹/前駆細胞、その培養方法および用途2010
- Inventor(s)
  酒井大輔、持田讓治、安藤潔、中村嘉彦
- Industrial Property Rights Holder
  東海大学共同
- Industrial Property Number
  2010-077743
- Filing Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-22791406
[Patent] 椎間板髄核幹/前駆細胞、その作成方法および用途2010
- Inventor(s)
  酒井大輔、持田讓治、安藤潔、中村嘉彦
- Industrial Property Rights Holder
  学校法人東海大学
- Filing Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20791056
[Presentation] 椎間板再生医療は腰痛治療となり得るか?2022
- Author(s)
  酒井大輔
- Organizer
  第95回　日本整形外科学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03809
[Presentation] 椎間板再生医療とリハビリテーションによる腰痛治療の変革への期待2022
- Author(s)
  酒井大輔
- Organizer
  第95回　日本整形外科学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03809
[Presentation] 椎間板変性に対する再生医療の産業化への挑戦2022
- Author(s)
  酒井大輔
- Organizer
  第51回　日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03809
[Presentation] Hunt for Transcriptional Control of Nucleus Pulposus Cells using iPS Cell Technology2020
- Author(s)
  酒井大輔
- Organizer
  ORS 2020 Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] 新規低分子IL-17A阻害剤による椎間板変性治療法の可能性を評価する2019
- Author(s)
  隅山香織、酒井大輔、平山令明、坂部貢、渡辺雅彦
- Organizer
  第48回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] Regenerative medicine for intervertebral disc degeneration: Challenges towards realization2019
- Author(s)
  酒井大輔
- Organizer
  第48回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] Reprogramming the Future of Cell Based Therapy for Intervertebral Disc Disease2019
- Author(s)
  酒井大輔
- Organizer
  ICRS 2019 International Cartilage Repair Society 15th World Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] 椎間板再生におけるスフェロイド形成培養法に関する基礎的検討2019
- Author(s)
  酒井大輔
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] In Silico創薬による新規低分子IL-17A阻害剤を用いた椎間板変性治療の可能性2019
- Author(s)
  隅山香織、酒井大輔、平山令明、坂部貢、渡辺雅彦
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] 腰痛診療up date2019～新腰痛診療ガイドラインからiPS細胞技術による椎間板再生まで～2019
- Author(s)
  酒井大輔
- Organizer
  第3回日本リハビリテーション医学会秋季学術集会
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] 表面マーカーを用いた細胞機能解析による椎間板再生の新知見2016
- Author(s)
  酒井大輔
- Organizer
  第45回日本脊椎脊髄病学会学術集会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] 椎間板再生医療が開く脊椎変性疾患治療の未来2016
- Author(s)
  酒井大輔
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05456
[Presentation] マウス線維輪培養細胞の分化過程におけるCD146の発現について2013
- Author(s)
  中井知子、中村嘉彦、酒井大輔、持田譲治
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場（千葉市）
- Data Source
  KAKENHI-PROJECT-24592212
[Presentation] Non-notochordal origin in chondrocyte-like cells of the nucleus pulposus appearing in early stage disc degeneration in the mouse model2012
- Author(s)
  田中真弘、酒井大輔、檜山明彦、田村太、新井文征、中島大輔、中井知子、持田讓治
- Organizer
  2012 Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Francisco CA, USA
- Year and Date
  2012-02-05
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] 活性化髄核細胞の凍結保存方法についての基礎的検討22011
- Author(s)
  田中真弘、酒井大輔、檜山明彦、田村太、新井文征、中島大輔、中井知子、持田讓治
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  ベイシア文化ホール、前橋
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] Basic research on cryopreservation of aqctivated human nucleus pulposus cells2011
- Author(s)
  Tanaka M, Sakai D, Mochida J
- Organizer
  ISSLS meeting at Gotenburg
- Place of Presentation
  Sweden
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] Basic research on cryopreservation of activated human nucleus pulposus cells2011
- Author(s)
  田中真弘、酒井大輔、檜山明彦、田村太、新井文征、中島大輔、中井知子、持田讓治
- Organizer
  2011 Annual Meeting of International Society for the Study of the Lumbar Spine
- Place of Presentation
  Gothenburg, Sweden
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] 活性化髄核細胞の凍結保存方法についての基礎的検討(第2報)2011
- Author(s)
  田中真弘, 酒井大輔, 檜山明彦, 新井文征, 中島大輔, 中井知子, 持田讓治
- Organizer
  日本整形外科学会雑誌
- Year and Date
  2011-08-28
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] 椎間板再生のための細胞移植療法臨床研究の進捗および幹細胞研究による新展開2010
- Author(s)
  酒井大輔、田中真弘、新井文征、持田讓治
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] 活性化髄核細胞の凍結保存法についての基礎的検討2010
- Author(s)
  田中真弘、酒井大輔、新井文征、持田讓治
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] 臨床への橋渡し研究の現況関節軟骨・骨・椎間板(ヒト幹細胞指針以後)椎間板再生のための細胞移植療法臨床研究の進捗および幹細胞研究による新展開2010
- Author(s)
  酒井大輔, 持田讓治
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  京都国際会議場(京都府)
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-22791406
[Presentation] 軟骨再生の基礎と臨床の進歩(椎間板を含む)椎間板再生細胞移植療法のその先に2010
- Author(s)
  酒井大輔, 持田讓治
- Organizer
  第83回日本整形外科学会学術総会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22791406
[Presentation] 椎間板再生のための細胞移植療法臨床研究の進捗および幹細胞研究による新展開2010
- Author(s)
  酒井大輔、田中真弘、新井文征、持田讓治
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] 椎間板再生のための細胞移植療法臨床研究の進捗および幹細胞研究による新展開2010
- Author(s)
  酒井大輔、田中真弘、新井文征、持田讓治
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  京都市
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] Stem Cell therapy for disc repair2010
- Author(s)
  Sakai D
- Organizer
  16th Triennial Congress of the Asia Pacific Orthopaedic Association
- Place of Presentation
  International Conference Center,(Taipei, Taiwan)
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-22791406
[Presentation] 活性化髄核細胞の凍結保存法についての基礎的検討2010
- Author(s)
  田中真弘、酒井大輔、新井文征、持田讓治
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  京都市
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] 椎間板再生医療における培養髄核細胞の質を簡便に評価できるアッセイの開発2009
- Author(s)
  酒井大輔, 田村太, 芹ヶ野健司, 持田讓治
- Organizer
  第38回日本脊椎脊髄病学
- Place of Presentation
  神戸ポートピアホテル(神戸市)
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-22791406
[Presentation] シンポジウム自家骨髄間葉系幹細胞により活性化された椎間板髄核細胞を用いた椎間板再生実現過程での問題点と対処2009
- Author(s)
  持田譲治, 酒井大輔
- Organizer
  第8回日本再生医療学会
- Place of Presentation
  東京
- Year and Date
  2009-03-05
- Data Source
  KAKENHI-PROJECT-20390405
[Presentation] Biological treatments : cells. how do they work2009
- Author(s)
  Sakai D
- Organizer
  Global Spine Conference
- Place of Presentation
  Westin St. Francis,(San Francisco, CA, USA)
- Year and Date
  2009-06-24
- Data Source
  KAKENHI-PROJECT-22791406
[Presentation] Stem cell therapy in disc : What happens to transplanted disc cells2009
- Author(s)
  Sakai D
- Organizer
  The 24th Annual Meeting of the North American Spine Society
- Place of Presentation
  Moscone West Convention Center,(San Francisco, CA, USA)
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-22791406
[Presentation] Cell-mediated therapy for interverebral disc repair2008
- Author(s)
  Daisuke, Sakai
- Organizer
  World Forum for Spine Research 2008
- Place of Presentation
  Westin Miyako, Kyoto
- Year and Date
  2008-01-26
- Data Source
  KAKENHI-PROJECT-18791060
[Presentation] 細胞レベルからの椎間板再生-細胞移植療法のその先に-2008
- Author(s)
  酒井大輔
- Organizer
  第19回日本腰痛学会
- Place of Presentation
  東京
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-20791056
[Presentation] 適切な組織再生に向けた椎間板の遺伝子発現解析大・小動物における相違2007
- Author(s)
  酒井大輔
- Organizer
  第36回日本脊椎脊髄病学会
- Place of Presentation
  石川県立音楽堂
- Year and Date
  2007-04-26
- Data Source
  KAKENHI-PROJECT-18791060
[Presentation] 椎間板内細胞移植療法の現状と展望2007
- Author(s)
  岩品徹, 酒井大輔, 持田譲治
- Organizer
  第15回日本腰痛学会
- Place of Presentation
  大阪市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 椎間板再生への細胞移植療法の展開2007
- Author(s)
  持田譲治, 酒井大輔, 岩品徹, 檜山明彦, 大見博子, 芹ケ野健司
- Organizer
  第80回日本整形外科学会学術総会
- Place of Presentation
  神戸市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] Cell-mediated therapy for interverebral disc repair2007
- Author(s)
  Daisuke, Sakai
- Organizer
  6th Combined Meeting of the Orthopaedic Research Societies
- Place of Presentation
  Hawaii Convention Center
- Year and Date
  2007-10-21
- Data Source
  KAKENHI-PROJECT-18791060
[Presentation] 運動器の再生医療臨床応用への関門椎間板内細胞移植法の臨床応用化に向けて大型動物での検討2006
- Author(s)
  岩品徹, 持田譲治, 酒井大輔
- Organizer
  第21回日本整形外科学会基礎学術集会
- Place of Presentation
  長崎
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] ヒト髄核細胞の分化,調整におけるCTGFの機能解析について細胞接着因子の発現変動から2006
- Author(s)
  酒井大輔, 岩品徹, 渡邉拓也, 檜山明彦, 大見博子, 持田譲治
- Organizer
  第21回日本整形外科学会基礎学術集会
- Place of Presentation
  長崎
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 椎間板変性に対する細胞移植療法-臨床応用化への道のり-2006
- Author(s)
  酒井大輔, 岩品徹, 持田譲治
- Organizer
  第35回日本脊椎脊髄病学会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] Combination of coculture system with mesenchymal stem cells and autologous platelet rich plasma significantly activates human nucleus pulposus cells2006
- Author(s)
  Iwashina T, Watanabe T, Sakai D, Mochida J
- Organizer
  51th annual meeting of Orthopaedic Research Society in USA
- Place of Presentation
  Chicago
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] Activation of human nucleus pulposus cells with autologous mesenchymal stem cells -In vitro pre-clinical study for transplantation of activated mucleus pulposus cells-2005
- Author(s)
  Watanabe T, Sakai D, Iwashina T, Mochida J
- Organizer
  51th annual meeting of Orthopaedic Research Society in USA
- Place of Presentation
  Washington DC
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 椎間板髄核細胞のマーカー解析-インテグリンアルファ-6は髄核特異的に発現する-2005
- Author(s)
  酒井大輔, 持田譲治
- Organizer
  第20回日本整形外科学会基礎学術集会
- Place of Presentation
  三重
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 大型動物における活性化髄核細胞,椎間板内移植療法の変性抑制効果2005
- Author(s)
  岩品徹, 酒井大輔, 渡邉拓也, 檜山明彦, 持田譲治
- Organizer
  第20回日本整形外科学会基礎学術集会
- Place of Presentation
  三重
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 活性化図威嚇細胞移植療法の臨床応用化に向けた研究-臨床症例10例における骨髄間葉系幹細胞(MSC)とのcoculture法の効果2005
- Author(s)
  渡邉拓也, 酒井大輔, 岩品徹, 檜山明彦, 大見博子, 持田譲治
- Organizer
  第20回日本整形外科学会基礎学術集会
- Place of Presentation
  三重
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 基礎の成果を臨床に萌芽的最先端医療-脊椎変性椎間板の再生を目指した幹細胞の応用実験系2004
- Author(s)
  酒井大輔, 持田譲治, 山本至宏, 岩品徹, 宮崎武志, 中井知子
- Organizer
  第19回日本整形外科学会基礎学術集会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 間葉系幹細胞との細胞間接着共培養法により活性化した髄核細胞再挿入術の検討2004
- Author(s)
  山本至宏, 酒井大輔, 宮崎武志, 岩品徹, 西村和博, 持田譲治
- Organizer
  第33回日本脊椎脊髄病学会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] 椎間板変性に対する細胞移植療法の臨床応用化に向けた研究大型動物における椎間板変性モデルの検討2004
- Author(s)
  岩品徹, 酒井大輔, 宮崎武志, 中井知子, 持田譲治
- Organizer
  第19回日本整形外科学会基礎学術集会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390443
[Presentation] マウス線維輪培養細胞に発現するCD146の機能
- Author(s)
  中井知子、中村嘉彦、酒井大輔、持田譲治
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島市
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24592212
[Presentation] 再生医療の最先端椎間板再生　ES細胞による細胞移植の可能性と線維輪再生に向けた新展開
- Author(s)
  酒井大輔, 中井知子, 額賀唯至, 持田讓治
- Organizer
  第87回日本整形外科学会学術総会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24592213

1. HIYAMA Akihiko (00514382)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. SUYAMA Kaori (20433914)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. MOCHIDA Joji (30129697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 82 results
4. MOCHIDA Joji (50174347)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAI Tomoko (20624589)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 平山令明 (70238393)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 升井伸治 (20342850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. IWASHINA Tooru (10433913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. NOMURA Takeshi (60246121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. OKUMA Masahiko (10317787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 根本仁 (40465183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 森雅樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 渡辺憲史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 清水孝彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAI DAISUKE 酒井 大輔

SAKAI Daisuke 酒井 大輔

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Development of of intervertebral disc regeneration technology using reprogramming, organoids, exosomes, and genome editingPrincipal Investigator

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Basic development for reprogramming methods and translation of regenerative medicine in intervertebral disc cellsPrincipal Investigator

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Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technologyPrincipal Investigator

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Analysis of appropriate cell source for efficient annulus fibrosis regenerationPrincipal Investigator

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Identifying the origin and niche environment of nucleus pulposus progenitor cells of the intervertebral disc and its therapeutic applicationsPrincipal Investigator

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SAKAI DAISUKE 酒井大輔

SAKAI Daisuke 酒井大輔