Okamoto Isamu 岡本勇

… Alternative Names

OKAMOTO Isamu 岡本勇

Less

Researcher Number	10411597
Affiliation (Current)	2025: 九州大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2015 – 2017: 九州大学, 大学病院, 講師 2014: 九州大学, 大学病院, 特任准教授 2014: 九州大学, 大学病院, 学術研究員 2013 – 2014: 九州大学, 大学病院, 研究員 2013: 九州大学, 医学部, 准教授 2009 – 2012: Kinki University, 医学部, 准教授 2006: Kinki University, School of Medicine. Medical Oncology, Assistant Professor, 医学部腫瘍内科, 講師
Review Section/Research Field	Principal Investigator Tumor therapeutics / Clinical oncology / Respiratory organ internal medicine Except Principal Investigator Clinical oncology / Respiratory organ internal medicine
Keywords	Principal Investigator EGFR遺伝子変異 / 非小細胞肺癌 / 癌幹細胞 / EGFR遺伝子 / 肺癌 / CD44 / ROS / レドックスバランス / 抗癌剤感受性 / グルタチオン … More / 上皮成長因子受容体(EGFR) / 活性酸素 / CD44バリアント(CD44v) / EML4-ALK融合遺伝子 / 分子標的治療 / 癌 / 呼吸器感染症 / 肺線維症 / 非閉塞性肺疾患 … More Except Principal Investigator 分子標的治療 / EGFR / 臨床腫瘍学 / dimerization / auto-phosphorylation / gene amplification / somatic mutation / tyrosine kinase inhibitor / Epidermal Growth Factor / Non Small Cell Lung Cancer / KRAS / コピー数の増加 / インフレーム変異 / ミスセンス変異 / Gefitinib / EGFR-TKIs / 非小細胞肺癌 / チロシンキナーゼ阻害剤(TKIs) / 二量体形成 / 自己リン酸化 / 遺伝子増幅 / 遺伝子変異 / チロシンキナーゼ阻害剤 / 上皮成長因子受容体(EGFR) / 非肺小細胞癌(NSCLC) / Resistance / MET / Gastric Cancer / 分子標的薬 / 胃癌 / MET遺伝子増幅 / ゲフィチニブ / ゲフィニチブ / 腫瘍治療学 / EML4-ALK / 肺癌 Less

Functional analysis of cancer stem cell marker CD44v in EGFR-mutated non-small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Okamoto Isamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyushu University
Multiplex molecular profiling in advanced non-small cell lung cancersPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Isamu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Kyushu University
  Kinki University
Antitumor Action of the MET Tyrosine Kinase Inhibitor in Gastric Cancer Positive for MET Amplification
- Principal Investigator
  
  OKAMOTO Wataru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  National Cancer Center Japan
  Kinki University
EML4-ALK陽性肺癌におけるシグナル伝達経路の解析
- Principal Investigator
  
  宮崎昌樹
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Kinki University
Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations.
- Principal Investigator
  
  OKAMOTO Kunio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Kinki University
Molecular-based approach for overcoming acquired resistance to EGFR tyrosine kinase inhibitorsPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Isamu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kinki University
Investigation of the relationship between EGFR gene status and clinical effect and the elucidation of the resistance mechanism
- Principal Investigator
  
  TAKADA Minoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  NHO Kinki-Chuo Chest Medical Center Clinical Research Center

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 Other

All Journal Article Presentation

[Journal Article] CD44 variant dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment2017
- Author(s)
  Kawano Y., Iwama E., Tsuchihashi K., Shibahara D., Harada T., Tanaka K., Nagano O., Saya H., Nakanishi Y. & Okamoto I.
- Journal Title
  
  Lung Cancer
  
  Volume: 113 Pages: 72-78
- DOI
  10.1016/j.lungcan.2017.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06874
[Journal Article] Survival outcome assessed according to tumor response and shrinkage pattern in patients with EGFR mutation-positive non-small cell lung cancer treated with gefitinib or erlotinib.2014
- Author(s)
  Takeda K, Okamoto I (Correspondence author), Nakagawa K
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 9(2) Pages: 200-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Multiplex genomic profiling of non–small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study2014
- Author(s)
  Okamoto I, Sakai K, Morita S, Yoshioka H, Kaneda H, Takeda K, Hirashima T, Kogure Y, Kimura T, Takahashi T, Atagi S, Seto T, Sawa T, Yamamoto M, Satouchi M, Okuno M, Nagase S, Takayama K, Tomii K, Maeda T, Oizumi S, Fujii S, Akashi Y, Nishino K, Ebi N, Nakagawa K, Nakanishi Y, Nishio K.
- Journal Title
  
  Oncotarget
  
  Volume: 5 Pages: 2293-2304
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Development of ALK inhibitors and molecular diagnosis in ALK rearrangement–positive lung cancer.2014
- Author(s)
  Iwama E, Okamoto I (Correspondence author), Harada T, Takayama K, Nakanishi Y
- Journal Title
  
  OncoTargets and Therapy
  
  Volume: 7 Pages: 375-385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer.2014
- Author(s)
  Azuma K, Ota K, Kawahara A, Hattori S, Iwama E, Harada T, Matsumoto K, Takayama K, Takamori S, Kage M, Hoshino T, Nakanishi Y, Okamoto I
- Journal Title
  
  Annals of Oncology
  
  Volume: 25 Issue: 10 Pages: 1935-1940
- DOI
  10.1093/annonc/mdu242
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement2014
- Author(s)
  Fujiwara A, MD, Higashiyama M, Kanou T, Tokunaga T, Okami J, Kodama K, Nishino K, Tomita Y, Okamoto I (Correspondence author)
- Journal Title
  
  Lung Cancer
  
  Volume: 83(2) Pages: 302-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Targeting MET Amplification as a New Oncogenic Driver.2014
- Author(s)
  Kawakami H, Okamoto I, Okamoto W, Tanizaki J, Nakagawa K, Nishio K.
- Journal Title
  
  Cancers(Basel)
  
  Volume: 6(3) Issue: 3 Pages: 1540-52
- DOI
  10.3390/cancers6031540
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24240122, KAKENHI-PROJECT-24501359, KAKENHI-PROJECT-24501360
[Journal Article] MET amplification as a potential therapeutic target in gastric cancer.2013
- Author(s)
  Kawakami H, Okamoto I, Arao T, Okamoto W, Matsumoto K, Taniguchi H, Kuwata K, Yamaguchi H, Nishio K, Nakagawa K, Yamada Y.
- Journal Title
  
  Oncotarget
  
  Volume: 4(1) Pages: 9-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501360
[Journal Article] A novel mass spectrometry–based assay for diagnosis of EML4-ALK–positive non–small cell lung cancer.2012
- Author(s)
  Sakai K, Okamoto I, Takezawa K, Hirashima T, Kaneda H, Takeda M, Matsumoto K, Kimura H, Fujita Y, Nakagawa K, Arao T, Nishio K.
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 7 Pages: 913-918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Association of the expression of mutant EGFR protein as determined with mutation-specific antibodies in non-small cell lung cancer with progression-free survival after gefitinib treatment2012
- Author(s)
  Azuma K, Okamoto I, Kawahara A, Taira T, Nakashima K, Hattori S, KinoshitaT, Takeda M, Nakagawa K, Takamori S, Kuwano M, Ono M, KageM
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 7 Pages: 122-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I clinical study of the angiogenesis inhibitor TSU-68 combined with carboplatin and paclitaxel in chemotherapy-naive patients with advanced non-small cell lung cancer2012
- Author(s)
  Okamoto I, Yoshioka H, Takeda K, Satouchi M, Yamamoto N, Seto T, Kasahara K, Miyazaki M, Kitamura R, Ohyama A, Hokoda N, Nakayama H, Yoshihara E, Nakagawa K
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 7 Pages: 427-433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin2012
- Author(s)
  Okamoto K, Okamoto I, Hatashita E, Kuwata K, Yamaguchi H, Kita A, Yamanaka K, Ono M, Nakagawa K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 11(1) Pages: 204-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501316
[Journal Article] Clinical Phase I Study of Elpamotide, a Peptide Vaccine for VEGFR 2, in Patients with Advanced Solid Tumors2012
- Author(s)
  Okamoto I, Arao T, Miyazaki M, Satoh T, Okamoto K, Tsunoda T, Nishio K, Nakagawa K
- Journal Title
  
  Cancer Science
  
  Volume: 103(12) Pages: 2135-2138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501316
[Journal Article] Clinical Outcome of Thoracic Radiotherapy for Locally Advanced NSCLC with EGFR Mutations or EML4-ALK.2012
- Author(s)
  Hayashi H, Okamoto I, Kimura H, Sakai K, Nishimura Y, Nishio K, Nakagawa K.
- Journal Title
  
  Anticancer Research
  
  Volume: 32(10) Pages: 4533-4537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Overcoming Erlotinib Resistance in EGFR Mutation-Positive Non-Small Cell Lung Cancer Cells by Targeting Survivin.2012
- Author(s)
  Okamoto K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 11 Pages: 204-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501316
[Journal Article] Overcoming Erlotinib Resistance in EGFR Mutation-Positive Non-Small Cell Lung Cancer Cells by Targeting SurvivinMolecular2012
- Author(s)
  Okamoto K, Okamoto I, Hatashita E, Kuwata K, Yamaguchi H, Kita A, Yamanaka K, Ono M, Nakagawa K
- Journal Title
  
  Cancer Therapeutics
  
  Volume: 11 Pages: 204-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] EML4-ALK-targeted therapy for advanced non-small cell lung cancer: molecular and clinical aspects.2012
- Author(s)
  Okamoto I, Nakagawa K
- Journal Title
  
  Cancer Science
  
  Volume: 103(8) Pages: 1391-1396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Combined effect of ALK and MEK inhibitor in EML4-ALK-positive non-small-cell lung cancer cells2012
- Author(s)
  Tanizaki J, Okamoto I, Takezawa K, Sakai K, Azuma K, Kuwata K, Yamaguchi H, Hatashita E, Nishio K, Janne PA, Nakagawa K
- Journal Title
  
  British Journal of Cancer
  
  Volume: 106 Pages: 763-767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Overcoming Erlotinib Resistance in EGFR Mutation-Positive Non-Small Cell Lung Cancer Cells by Targeting Survivin2012
- Author(s)
  Okamoto K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 11 Pages: 204-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Clinical outcome for EML4-ALK–positive patients with advanced non–small cell lung cancer treated with first-line platinum-based chemotherapy.2012
- Author(s)
  Takeda M, Okamoto I, Sakai K, Kawakami K, Nishio K, Nakagawa K.
- Journal Title
  
  Annals of Oncology
  
  Volume: 23(11) Pages: 2931-2936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Phase I clinical study of the angiogenesis inhibitor TSU-68 combined with carboplatin and paclitaxel in chemotherapy-naive patients with advanced non-small cell lung cancer2012
- Author(s)
  Okamoto I
- Journal Title
  
  J Thorac Oncol
  
  Volume: 7(2) Pages: 427-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501315
[Journal Article] Marked response to both S-1 and pemetrexed in a patient with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase-positive lung adenocarcinoma.2012
- Author(s)
  Kaneda H, Okamoto I, Sakai K, Tanizaki J, Takeda M, Nishio K, Nakagawa K.
- Journal Title
  
  Acta Oncologica
  
  Volume: 51(7) Pages: 942-944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification.2012
- Author(s)
  Okamoto W, Okamoto I, Arao T, Kuwata K, Hatashita E, Yamaguchi H, Sakai K, Yanagihara K, Nishio K, Nakagawa K.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 11(7) Pages: 1557-1564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501360
[Journal Article] Clinical phase I study of elpamotide, a peptide vaccine for vascular endothelial growth factor receptor 2, in patients with advanced solid tumors.2012
- Author(s)
  Okamoto I, Arao T, Miyazaki M, Satoh T, Okamoto K, Tsunoda T, Nishio K, Nakagawa K.
- Journal Title
  
  Cancer Sci
  
  Volume: 103(12) Pages: 2135-2138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501316
[Journal Article] Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer.2012
- Author(s)
  Tanizaki J, Okamoto I, Okabe T, Sakai K, Tanaka K, Hayashi H, Kaneda H, Takezawa K, Kuwata K, Yamaguchi H, Hatashita E, Nishio K, Nakagawa K.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 18(22) Pages: 6219-6226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501359
[Journal Article] Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors2012
- Author(s)
  Okamoto I, Shimizu T, Miyazaki M, Tsurutani J, Ichikawa Y, Terashima M, Takeda M, Fumita S, Ohki E, Kimura N, Hashimoto J, Nakagawa K
- Journal Title
  
  Investigational New Drugs
  
  Volume: 30 Pages: 639-646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors2012
- Author(s)
  Okamoto I
- Journal Title
  
  Invest New Drugs
  
  Volume: 30(2) Pages: 639-646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501315
[Journal Article] Roles of BIM induction and survivin down-regulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification2011
- Author(s)
  Tanizaki J, Okamoto I, Fumita S, Okamoto W, Nishio K, Nakagawa K
- Journal Title
  
  Oncogene
  
  Volume: 30 Pages: 4097-4106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small cell lung cancer harboring mutations of the epidermal growth factor receptor2011
- Author(s)
  Okamoto I, Takahashi T, Okamoto H, Nakagawa K, Watanabe K, Nakamatsu K, Nishimura Y, Fukuoka M, Yamamoto N
- Journal Title
  
  Lung Cancer
  
  Volume: 72(1) Pages: 199-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells2011
- Author(s)
  Okamoto W
- Journal Title
  
  British Journal of Cancer
  
  Volume: 105(3) Pages: 407-412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab2011
- Author(s)
  Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, Ercan D, Rogers A, Roncalli M, Takeda M, FujisakaY, Philips J, Shimizu T, Maenishi O, Cho Y, Sun J, Destro A, Taira K, Takeda K, OkabeT, Swanson J, Itoh H, Takada M, Lifshits E, Okuno K, Engelman A J, Shivdasani A R, Nishio K, Fukuoka M, Garcia V M, Nakagawa K, and Janne A. P
- Journal Title
  
  Science Translation Medicine
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer2011
- Author(s)
  Takezawa K, Okamoto I, Nishio K, Janne P, Nakagawa K
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 17(8) Pages: 2140-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Thymidylate synthase and dihydropyrimidine dehydrogenase expression levels are associated with response to S-1 plus carboplatin in advanced non-small cell lung cancer2011
- Author(s)
  Takeda M, Okamoto I, Hirabayashi N, Kitano M, Nakagawa K
- Journal Title
  
  Lung Cancer
  
  Volume: 73(1) Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification2011
- Author(s)
  Tanizaki J, Okamoto I, Sakai K, Nakagawa K
- Journal Title
  
  British Journal of Cancer
  
  Volume: 105 Pages: 807-813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Differential roles of STAT3 depending on the mechanism of STAT3 activation in gastric cancer cells2011
- Author(s)
  Okamoto W, Okamoto I, Arao T, Yanagihara K, Nishio K, Nakagawa K
- Journal Title
  
  British Journal of Cancer
  
  Volume: 105(3) Pages: 407-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET Alterations2011
- Author(s)
  Tanizaki J, Okamoto I, Okamoto K, Takezawa K, Kuwata K, Yamaguchi H, Nakagawa K
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 6(10) Pages: 1624-1631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501316
[Journal Article] Single-agent gefitinib with concurrent radiotherapy for locally advanced non-small cell lung cancer harboring mutations of the epidermal growth2011
- Author(s)
  Okamoto I
- Journal Title
  
  Lung Cancer
  
  Volume: 72(1) Pages: 199-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors.2011
- Author(s)
  Okamoto I
- Journal Title
  
  Investigational New Drugs.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] MET Tyrosine Kinase Inhibitor Crizotinib(PF-02341066) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET Alterations2011
- Author(s)
  Tanizaki J, Okamoto I, Okamoto K, Takezawa K, Kuwata K, Yamaguchi H, Nakagawa K
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 10 Pages: 1624-1634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] High-dose dexamethasone plus antihistamine prevents colorectal cancer patients treated with modified FOLFOX6 from hypersensitivity reactions induced by oxaliplatinHigh-dose dexamethasone plus antihistamine prevents colorectal cancer patients treated with modified FOLFOX6 from hypersensitivity reactions induced by oxaliplatin2011
- Author(s)
  Kidera Y, Satoh T, Ueda S, Okamoto W, Okamoto I, Fumita S, Yonesaka K, Hayashi H, Makimura C, Okamoto K, Kiyota H, Tsurutani J, Miyazaki M, Yoshinaga M, Fujiwara K, Yamazoe Y, Moriyama K, Tsubaki M, Chiba Y, Nishida S, Nakagawa K
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 16(3) Pages: 244-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501316
[Journal Article] Tymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer2011
- Author(s)
  Takezawa K, Okamoto I, Okamoto W, Takeda M, Sakai K, Tsukioka S, Kuwata K, Yamaguchi H, Nishio K, Nakagawa K
- Journal Title
  
  British Journal of Cancer
  
  Volume: 104(10) Pages: 1594-601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors2010
- Author(s)
  Okamoto I, Kaneda H, Satoh T, Okamoto W, Miyazaki M, Morinaga R, Ueda S, Terashima M, Tsuya A, Sarashina A, Konishi K, Arao T, Nishio K, Kaiser R, Nakagawa K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(10) Pages: 2825-2833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition2010
- Author(s)
  Okamoto W, Okamoto I, Yoshida T, Okamoto K, Takezawa K, Hatashita E, Yamada Y, Kuwata K, Arao T, Yanagihara K, Fukuoka M, Nishio K, Nakagawa K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(5) Pages: 1188-1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Identification of thymidylate synthase as a potential therapeutic target for lung cancer2010
- Author(s)
  Takezawa K, Okamoto I, Tsukioka S, Uchida J, Kiniwa M, Fukuoka M, Nakagawa K
- Journal Title
  
  British Journal of Cancer
  
  Volume: 103(3) Pages: 354-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I Clinical and Pharmacokinetic Study of RAD001 (Everolimus) Administered Daily to Japanese Patients with Advanced Solid Tumors.2010
- Author(s)
  Okamoto I
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 40(1) Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Epidermal growth factor receptor in relation to tumor development : EGFR-targeted anticancer therapy2010
- Author(s)
  Okamoto I
- Journal Title
  
  FEBS Journal
  
  Volume: 277(2) Pages: 309-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations2010
- Author(s)
  Okamoto K, Okamoto I, Okamoto W, Tanaka K, Takezawa K, Kuwata K, Yamaguchi H, Nishio K, Nakagawa K
- Journal Title
  
  Cancer Research
  
  Volume: 70(24) Pages: 10402-10410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] TAK-701, a humanized monoclonal antibody to HGF, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation2010
- Author(s)
  Okamoto W, Okamoto I, Tanaka K, Hatashita E, Yamada Y, Kuwata K, Yamaguchi H, Arao T, Nishio K, Fukuoka M, Janne PA, Nakagawa K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(10) Pages: 2785-2792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Disturbance of the Growth Hormone-Insulin-like Growth Factor-1 Axis Associated with Poor Performance Status in Patients with Solid Tumors.2010
- Author(s)
  Okamoto I
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 40(3) Pages: 222-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Does escalation study of pemetrexed in combination with carboplatin followed by pemetrexed maintenance therapy for advanced non-small cell lung cancer2010
- Author(s)
  Okamoto I, Takeda K, Daga H, Miyazaki M, Yonesaka K, Kiyota H, Tsurutani J, Ueda S, Ichikawa Y, Takeda M, Sekiguchi R, Tominaga K, Enatsu S, Nambu Y, Nakagawa K
- Journal Title
  
  Lung Cancer
  
  Volume: 70(2) Pages: 168-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Rundomeed, on-label, phase 111, noninferiority, trial comparing oral 5-1 plus curboplatlin with pacllranet plow carhnplat fhewNmvapv-nelve unueuts pith advanced icon-small cell lung cancer : result of a Rust Japan Oncology GI-1 (WTS) study2010
- Author(s)
  Okamoto I
- Journal Title
  
  Journal of Clinical Oncology
  
  Volume: 28(36) Pages: 5240-5246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Cisplatin and Etoposide Chemotherapy Combined with Early Concurrent Twice daily Thoracic Radiotherapy for Limited-disease Small Cell Lung Cancer in2010
- Author(s)
  Okamoto K
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 40(1) Pages: 54-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition.2010
- Author(s)
  Okamoto W
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(5) Pages: 1188-1197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer2010
- Author(s)
  Okamoto I, Miyazaki M, Morinaga R, Kaneda H, Ueda S, Hasegawa Y, Satoh T, Kawada A, Fukuoka M, Fukino K, Tanigawa T, Nakagawa K
- Journal Title
  
  Investigational New Drugs
  
  Volume: 28(6) Pages: 844-853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] The emerging role of epidermal growth factor receptor(EGFR) inhibitors in first-line treatment for patients with advanced non-small cell lung cancer positive for EGFR mutations2010
- Author(s)
  Okamoto I. Mitsudomi T, Nakagawa K, Fukuoka M
- Journal Title
  
  Therapeutic Advences in Medical Oncology
  
  Volume: 2(5) Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Cisplatin and Etoposide Chemotherapy Combined with Early Concurrent Twice-daily Thoracic Radiotherapy for Limited-disease Small Cell Lung Cancer in Elderly Patients2010
- Author(s)
  Okamoto K
- Journal Title
  
  Japanese Journal of Clinical Oncology 40(1)
  
  Pages: 54-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for FGFR mutations.2010
- Author(s)
  Okamoto K
- Journal Title
  
  Cancer Research
  
  Volume: 70(24) Pages: 10402-10410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I clinical and pharmacokinetic study of sorafenib in combination with carhoplatin and paclitaxel in patients with advanced non-small cell lung cancer.2010
- Author(s)
  Okamoto I
- Journal Title
  
  Investigational New Drugs
  
  Volume: 28(6) Pages: 844-853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor2010
- Author(s)
  Takezawa K, Okamoto I, Tanizaki J, Kuwata K, Yamaguchi H, Fukuoka M, Nishio K, Nakagawa K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(6) Pages: 1647-1656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I Clinical and Pharmacokinetic Study of RAD001(Everolimus) Administered Daily to Japanese Patients with Advanced Solid Tumors2010
- Author(s)
  Okamoto I, Doi T, Ohtsu A, Miyazaki M, Tsuya A, Kurei K, Kobayashi K, Nakagawa K
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 40(1) Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Synergistic antitumor effect of S-1 and HER2-targeting agents in gastric cancer with HER2 amplification2010
- Author(s)
  Tanizaki J, Okamoto I, Takezawa K, Tsukioka S, Uchida J, Kiniwa M, Fukuoka M, Nakagawa K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(5) Pages: 1198-1207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs2010
- Author(s)
  Iwasa T, Okamoto I, Takezawa K, Yamanaka K, Nakahara T, Kita A, Koutoku H, Sasamata M, Hatashita E, Yamada Y, Kuwata K, Fukuoka M, Nakagawa K
- Journal Title
  
  British Journal of Cancer
  
  Volume: 103(1) Pages: 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Randomized, open-label, phase III, noninferiority trial comparing oral S-1 plus carboplatin with paclitaxel plus carboplatin in chemotherapy-naive patients with advanced non-small cell lung cancer : results of a West Japan Oncology Group(LETS) study2010
- Author(s)
  Okamoto I, Yoshioka H, Morita S, Ando M, Takeda K, Seto T, Yamamoto N, Saka H, Asami K, Hirashima T, Kudoh S, Satouchi M, Ikeda N, Iwamoto Y, Sawa T, Miyazaki M, Tamura K, Kurata K, Fukuoka M, Nakagawa K
- Journal Title
  
  Journal of Clinical Oncology
  
  Volume: 28(36) Pages: 5240-5246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] TAK-701, a humanized monoclonal antibody to HGF, reverses gefitinib resistance induced bytumor-derived HGF in non-small cell lung cancer with an EGFR mutation.2010
- Author(s)
  Okamoto W
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(10) Pages: 2785-2792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] S-1 : a new oral fluoropyrimidine in the treatment of patients with advanced non-small-cell lung cancer2010
- Author(s)
  Okamoto I
- Journal Title
  
  Clinical Lung Cancer 10(4)
  
  Pages: 290-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Successful treatment with erlotinib after gefitinib-induced severe interstitial lung disease2010
- Author(s)
  Takeda M, Okamoto I, Makimura C, Fukuoka M, Nakagawa K
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 5(7) Pages: 1103-1104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Epidermal growth factor receptor in relation to tumor development : EGFR-targeted anticancer therapy2010
- Author(s)
  Okamoto I
- Journal Title
  
  FEBS Journal 277(2)
  
  Pages: 309-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Disturbance of the Growth Hormone-Insulin-like Growth Factor-1 Axis Associated with Poor Performance Status in Patients with Solid Tumors2010
- Author(s)
  Okamoto I, Munakata M, Miyazaki M, Satoh T, Takahata T, Takamatsu Y, Muto O, Koike K, Ishitani K, Mukaiyama T, Sakata Y, Nakagawa K, Tamura K
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 40(3) Pages: 222-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I Clinical and Pharmacokinetic Study of RAD001(Everolimus)Administered Daily to Japanese Patients with Advanced Solid Tumors2010
- Author(s)
  Okamoto I
- Journal Title
  
  Japanese Journal of Clinical Oncology 40(1)
  
  Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Epidermal growth factor receptor in relation to tumor development EGFR targeted anticancer therapy.2010
- Author(s)
  Okamoto I
- Journal Title
  
  FEBS Journal
  
  Volume: 277(2) Pages: 309-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Ora Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors.2010
- Author(s)
  Okamoto I
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 9(10) Pages: 2825-2833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Does escalation study of pemetrexed in combination with carboplatin followed by pemetrexed maintenance therapy for advanced non-small cell2010
- Author(s)
  Okamoto I
- Journal Title
  
  Lung Cancer
  
  Volume: 70(2) Pages: 168-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] The emerging role of epidermal growth factor receptor (EGFR) inhibitors in first-line treatment for patients with advanced non-small cell lung cancer positive for2010
- Author(s)
  Okamoto I
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: 2(5) Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Zoledronic acid-induced regression of multiple metastases at nonskeletal sites2009
- Author(s)
  Okamoto K
- Journal Title
  
  Annals of Oncology 20(4)
  
  Pages: 796-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591011
[Journal Article] Differential constitutive activation of the Epidermal Growth Factor Receptor (EGFR) in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.2007
- Author(s)
  Isamu Okamoto
- Journal Title
  
  Cancer Research. 67
  
  Pages: 2046-2053
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590812
[Journal Article] Differential constitutive activation of the Epidermal Growth Factor Receptor (EGFR) in non- small cell lung cancer cells bearing EGFR gene mutation and amplification.2007
- Author(s)
  Isamu Okamoto
- Journal Title
  
  Cancer Research. 67
  
  Pages: 2046-2053
- Data Source
  KAKENHI-PROJECT-17590812
[Journal Article] Differential constitutive activation of the Epidermal Growth Factor Receptor (EGFR) in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.2007
- Author(s)
  Okabe T, Okamoto I, Tamura K, Terashima M, Yoshida T, Satoh T, Takada M, Fukuoka M, Nakagawa K
- Journal Title
  
  Cancer Res 67(5)
  
  Pages: 2046-2053
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590812
[Presentation] EGFR遺伝子変異陽性非小細胞肺癌における、CD44v、EGFRシグナルを介した活性酸素制御2016
- Author(s)
  河野裕子、岡本勇、岩間映二、原田大志、土橋賢司、永野修、佐谷秀行、中西洋一
- Organizer
  がん分子標的治療学会
- Place of Presentation
  大分県別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15K06874
[Presentation] EGFR遺伝子変異陽性非小細胞肺癌における、CD44ｖ、EGFRシグナルを介した活性酸素制御2016
- Author(s)
  河野裕子、岡本勇、岩間映二、原田大志、土橋賢司、永野修、佐谷秀行、中西洋一
- Organizer
  がん分子標的治療学会
- Place of Presentation
  大分県別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15K06874
[Presentation] Expression of CD44 variants in EGFR-mutation positive non-small cell lung cancer (NSCLC)2015
- Author(s)
  河野裕子、岡本勇
- Organizer
  日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06874
[Presentation] Antitumor action of the MET tyrosine kinase inhibitor crizotinib in gastric cancer positive for MET amplification2013
- Author(s)
  Wataru Okamoto, Isamu Okamoto, Hisato Kawakami, Kazuyoshi Yanagihara, Kazuto Nishio, Kazuhiko Nakagawa
- Organizer
  International Symposium of Korean Society of Gastrointestinal Cancer
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-24501360
[Presentation] サバイビンを標的としたEGFR チロシンキナーゼ阻害剤に対する耐性克服2013
- Author(s)
  岡本勇,岡本邦男,清水俊雄,中川和彦
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] Biomarker analyses in clinical trials for NSCLC2013
- Author(s)
  Isamu Okamoto
- Organizer
  第11回日本臨床腫瘍学会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24501359
[Presentation] サバイビンを標的としたEGFRチロシンキナーゼ阻害剤に対する耐性克服2013
- Author(s)
  岡本勇、岡本邦男、清水俊雄、中川和彦
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都市左京区
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] ベバジズマブ投与による喀血症例において気管支内視鏡検査での経時観察が出来た1例2012
- Author(s)
  岡本邦男
- Organizer
  第95回日本肺癌学会関西支部会
- Place of Presentation
  薬業年金会館(大阪市)
- Year and Date
  2012-02-25
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] EGFR遺伝子変異陽性非小細胞肺癌に対するサバイビンを標的としたErlotinib耐性の克服2012
- Author(s)
  岡本邦男
- Organizer
  第10回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] EGFR 遺伝子変異陽性非小細胞肺癌に対するサバイビンを標的としたErlotinib 耐性の克服2012
- Author(s)
  岡本邦男
- Organizer
  第10回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] MET遺伝子増幅陽性胃癌に対するMETチロシンキナーゼ阻害剤クリゾチニブの抗腫瘍効果2012
- Author(s)
  岡本渉、岡本勇、荒尾徳三、仁科慎一、上田眞也、川上尚人、柳原五吉、倉田宝保、西尾和人、中川和彦
- Organizer
  第10回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪府大阪市大阪国際会議場
- Data Source
  KAKENHI-PROJECT-24501360
[Presentation] ベバジズマブ投与による喀血症例において気管支内視鏡検査での経時観察が出来た１例2012
- Author(s)
  岡本　邦男
- Organizer
  第95回日本肺癌学会関西支部会
- Place of Presentation
  薬業年金会館（大阪市）
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] MassARRAYによるEML4-ALK検出系の構築2012
- Author(s)
  坂井和子、岡本勇、竹澤健、平島智徳、金田裕靖、武田真幸、松本和子、木村英晴、藤田至彦、中川和彦、荒尾徳三、西尾和人
- Organizer
  第10回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪府大阪市大阪国際会議場
- Data Source
  KAKENHI-PROJECT-24501359
[Presentation] Clinical outcome for EML4-ALK-positive patients with advanced non-small cell lung cancer treated with first-line platinumbased　chemotherapy.2012
- Author(s)
  Masayuki Takeda, Isamu Okamoto, Kazuko Sakai, Hisato Kawakami, Kazuto Nishio, Kazuhiko Nakagawa.
- Organizer
  第10回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪府大阪市大阪国際会議場
- Data Source
  KAKENHI-PROJECT-24501359
[Presentation] 肺癌治療のControversy非小細胞肺癌治療におけるEGFRチロシンキナーゼ阻害剤(EGFR-TKIs)の諸問題2011
- Author(s)
  岡本勇
- Organizer
  第9回日本臨床腫瘍学会学術集会ワークショップ
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations2011
- Author(s)
  岡本　邦男
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] Controversies in the Treatment for Advanced Cancer Controversies in the maintenance therapy for metastatic NSCLC2011
- Author(s)
  Okamoto I
- Organizer
  第9回日本臨床腫瘍学会学術集会ASCO/JSMO Joint Symposium
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 化学放射線療法の新展開放射線療法における分子標的治療薬の役割と展望2011
- Author(s)
  岡本勇
- Organizer
  第9回日本臨床腫瘍学会学術集会日本臨床腫瘍学会・日本放射線腫瘍学会合同シンポジウム
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Emerging role of pemetrexed for first-line and maintenance chemotherapy for advanced nonsquamous NSCLC2011
- Author(s)
  岡本勇
- Organizer
  第52回日本肺癌学会総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2011-11-03
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] サバイビンがEGFR遺伝子変異陽性非小細胞肺癌においてEGFR-TKI　によるアポトーシスに果たす役割2011
- Author(s)
  岡本　邦男
- Organizer
  第15回日本がん分子標的治療学会
- Place of Presentation
  ホテル日航東京（東京都港区）
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] Molecular Based Patient Selection in Global Clinical Trials for Non-Small Cell Lung Cancer2011
- Author(s)
  Okamoto I
- Organizer
  The European Multidisciplinary Cancer CongressESMO/JSMO Joint Symposium
- Place of Presentation
  ストックホルム(スウェーデン)
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive forEGFR mutations2011
- Author(s)
  岡本邦男
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] 化学療法総論II:分子標的薬剤の種類2011
- Author(s)
  岡本勇
- Organizer
  第9回日本臨床腫瘍学会第18回教育セミナーBセッション
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 非小細胞肺癌治療に対する放射線化学療法における分子標的治療薬の役割と展望2011
- Author(s)
  岡本勇
- Organizer
  第13回癌治療増感研究シンポジウム
- Place of Presentation
  猿沢荘(奈良市)
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] サバイビンがEGFR 遺伝子変異陽性非小細胞肺癌においてEGFR-TKI によるアポトーシスに果たす役割2011
- Author(s)
  岡本邦男
- Organizer
  第15回日本がん分子標的治療学
- Place of Presentation
  ホテル日航東京(東京都港区)
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-23501316
[Presentation] 非小細胞肺癌治療に対する放射線化学療法における分子標的治療薬の役割と展望2011
- Author(s)
  岡本勇
- Organizer
  第13回癌治療増感研究シンポジウム
- Place of Presentation
  猿沢荘(奈良県)
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Controversies in the Treatment for Advanced Cancer Controversies in the maintenance therapy for metastatic NSCLC2011
- Author(s)
  Okamoto I
- Organizer
  第9回日本臨床腫瘍学会学術集会ASCO/JSMO Joint Symposium
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 化学放射線療法の新展開放射線療法における分子標的治療薬の役割と展望2011
- Author(s)
  岡本勇
- Organizer
  第9回日本臨床腫瘍学会学術集会日本臨床腫瘍学会・日本放射線腫瘍学会合同シンポジウム
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 肺癌治療のControversy非小細胞肺癌治療におけるEGFRチロシンキナーゼ阻害剤(EGFR-TKIs)の諸問題2011
- Author(s)
  岡本勇
- Organizer
  第9回日本臨床腫瘍学会学術集会ワークショップ
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] がん分子標的治療薬の耐性化メカニズム:基礎と臨床2010
- Author(s)
  岡本勇
- Organizer
  第14回日本がん分子標的治療学会総会
- Place of Presentation
  タワーホール船堀(東京江戸川区)
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 抗がん薬耐性と臨床薬理最近の展開がん分子標的剤における耐性機構とその克服2010
- Author(s)
  岡本勇
- Organizer
  第31回日本臨床薬理学会総会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 進行非小細胞肺癌の化学療法における病理診断の重要性2010
- Author(s)
  岡本勇
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 肺癌の分子標的治療-基から臨床へ分子標的治療薬の作用機序から伺える今後の展開2010
- Author(s)
  岡本勇
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島国際会議場(広島県)
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Lung Cancer : ASC02010 topics2010
- Author(s)
  Okamoto I
- Organizer
  Best of ASCO in Japan
- Place of Presentation
  東京ビッグサイト国際会議場(東京)
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] EGFR-TKI therapy for EGFR-mutated non-small cell lung cancer2010
- Author(s)
  Okamoto I
- Organizer
  第48回日本癌治療学会総会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Chemo-radiation for locally advanced NSCLC Integration of EGFR-targeted agents2010
- Author(s)
  Okamoto I
- Organizer
  9th International Conference of the Asian Clinical Oncology Society(ACOS)
- Place of Presentation
  岐阜グランドホテル(岐阜市)
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 進行非小細胞肺癌治療における分子標的治療の実地導入2010
- Author(s)
  岡本勇
- Organizer
  第98回日本呼吸器学会東海地方学会
- Place of Presentation
  三重県総合文化センター(三重県)
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 肺癌の分子標的治療肺がん診療における血管新生阻害剤の現状と課題2010
- Author(s)
  岡本勇
- Organizer
  第48回日本癌治療学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Chemo-radiation for locally advanced NSCLC Integration of EGFR-targeted agents2010
- Author(s)
  Okamoto I
- Organizer
  9th International Conference of the Asian Clinical Oncology Society (ACOS)
- Place of Presentation
  岐阜グランドホテル(岐阜県)
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 肺癌の分子標的治療-基礎から臨床へ分子標的治療薬の作用機序から伺える今後の展開2010
- Author(s)
  岡本勇
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 非小細胞肺癌におけるTS-1の新たなエビデンス-Counterattack of 5-FU agents in NSCLC-2010
- Author(s)
  岡本勇
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 進行非小細胞肺癌治療における分子標的治療の実地導入2010
- Author(s)
  岡本勇
- Organizer
  第98回日本呼吸器学会東海地方学会
- Place of Presentation
  三重県総合文化センター(津市)
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] がん分子標的治療薬の耐性化メカニズム:基礎と臨床2010
- Author(s)
  岡本勇
- Organizer
  第14回日本がん分子標的治療学会総会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Emerging role of new oral agent S-1 in treatment of advanced NSCLC2010
- Author(s)
  Okamoto I
- Organizer
  The 13th Chinese Society of Clinical
- Place of Presentation
  Jiuhua Resort and Convention Center(中国北京)
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 化学療法I非小細胞肺がん2010
- Author(s)
  岡本勇
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 非小細胞肺癌におけるTS-1の新たなエビデンス-Counterattack of 5-FU agents in NSCLC-2010
- Author(s)
  岡本勇
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島国際会議場(広島県)
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 進行非小細胞肺癌の化学療法における病理診断の重要性2010
- Author(s)
  岡本勇
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2010-04-27
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] EGFR-TKI for EGFR mutated NSCLC : New evidence2010
- Author(s)
  Okamoto I
- Organizer
  35th European Society of Clinical Oncology
- Place of Presentation
  FIERA MILANO(イタリアミラノ)
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 抗がん薬耐性と臨床薬理最近の展開がん分子標的剤における耐性機構とその克服2010
- Author(s)
  岡本勇
- Organizer
  第31回日本臨床薬理学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 局所進行非小細胞肺癌に対する放射線化学療法に対する新展開～分子標的治療薬の役割～2010
- Author(s)
  岡本勇
- Organizer
  第92回日本肺癌学会関西支部会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] EGFR-TKI therapy for EGFR-mutated non-small cell lung cancer2010
- Author(s)
  Okamoto I
- Organizer
  第48回日本癌治療学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 局所進行非小細胞肺癌に対する射線化学療法に対する新展開～分子標的治療薬の役割～2010
- Author(s)
  岡本勇
- Organizer
  第92回日本肺癌学会関西支部会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 化学療法1 非小細胞肺がん2010
- Author(s)
  岡本勇
- Organizer
  第51回日本肺癌学会総会
- Place of Presentation
  広島国際会議場(広島県)
- Year and Date
  2010-11-04
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] 肺癌の分子標的治療肺がん診療における血管新生阻害剤の現状と課題2010
- Author(s)
  岡本勇
- Organizer
  第48回日本癌治療学会総会
- Place of Presentation
  国立京都国際会(京都府)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] MET遺伝子増幅を伴うゲフィチニプ獲得耐性非小細胞肺癌におけるSrc阻害剤の効果2009
- Author(s)
  岡本勇
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコヨコハマ(神奈川県)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Phase I Clinical and Biomarker Study of BIBF11202009
- Author(s)
  岡本勇
- Organizer
  45th Annual Meeting of the American Society of Clinical Oncology
- Place of Presentation
  Orange County Convention Center(アメリカフロリダ州)
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Phase I Clinical and Biomarker Study of BIBF11202009
- Author(s)
  Isamu Okamoto
- Organizer
  45th Annual Meeting of the American Society of Clinical Oncology
- Place of Presentation
  County Convention Center(アメリカフロリダ州)
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] MET遺伝子増幅を伴うゲフィチニブ獲得耐性非小細胞肺癌におけるSrc阻害剤の効果2009
- Author(s)
  岡本勇
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコヨコハマ(横浜市)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] シンポジウム;分子標的治療の基礎と臨床EGFR遺伝子検査とEGFR-TKI治療の実践2009
- Author(s)
  岡本勇
- Organizer
  第50回日本肺癌学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] パネルデイスカッション;非小細胞肺癌の組織型と治療戦略化学療法(分子標的治療を含む)2009
- Author(s)
  岡本勇
- Organizer
  第50回日本肺癌学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] EGFR-TKI in non-small cell lung cancer ～WJOG trial～2009
- Author(s)
  岡本勇
- Organizer
  WJOG 3rd International Symposium on Clinical Trial
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] パネルデイスカッション;非小細胞肺癌の組織型と治療戦略化学療法(分子標的治療を含む)2009
- Author(s)
  岡本勇
- Organizer
  第50回日本肺癌学会総会
- Place of Presentation
  京王プラザホテル(東京都新宿区)
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] シンポジウム;分子標的治療の基礎と臨床 EGFR遺伝子検査とEGFR-TKI治療の実践2009
- Author(s)
  岡本勇
- Organizer
  第50回日本肺癌学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Molecular-based treatment strategy in EGFR-targeted therapies2009
- Author(s)
  岡本勇
- Organizer
  The 19th HCS-The 3rd Three Universities' Consortium International Symposium
- Place of Presentation
  広島国際会議場(広島県)
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Molecular-based treatment strategy in EGFR-targeted therapies2009
- Author(s)
  Isamu Okamoto
- Organizer
  The 19th HCS-The 3rd Three Universities' Consortium International Symposium
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-21591011
[Presentation] Multiplex genomic profiling of non-small cell lung cancer patients enrolled in the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin (WJOG6611LTR)
- Author(s)
  H Yoshioka, I Okamoto, K Sakai, S Morita, H Kaneda, K Takeda, T Hirashima, Y Kogure, T Kimura, T Takahashi, S Atagi, T Seto, T Sawa, M Yamamoto, M Satouchi, M Okuno, S Nagase, K Nakagawa, Y Nakanishi, K Nishio
- Organizer
  ASCO Annual Meeting
- Place of Presentation
  Chicago
- Year and Date
  2014-05-30 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-24501359

1. NAKAGAWA Kazuhiko (40298964)

# of Collaborated Projects: 5 results

# of Collaborated Products: 51 results
2. NISHIO Kazuto (10208134)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
3. OKAMOTO Kunio (90460865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
4. SAKAI Kazuko (20580559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. OKAMOTO Wataru (30441075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. ARAO Tokuzo (20441074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. TAKADA Minoru (20373516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. OKADA Masaji (40160684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWAHARA Masaoki (30344352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SASAKI Hidefumi (00336695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUKUOKA Jyunya (00324575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 宮崎昌樹 (90319682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 原田大志 (10380619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 中西洋一 (20172356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 岩間映二 (40567343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 田中謙太郎 (00536849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. KAWAKAMI Hisato

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Okamoto Isamu 岡本 勇

OKAMOTO Isamu 岡本 勇

Research Projects

Research Products

Co-Researchers

Functional analysis of cancer stem cell marker CD44v in EGFR-mutated non-small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Multiplex molecular profiling in advanced non-small cell lung cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antitumor Action of the MET Tyrosine Kinase Inhibitor in Gastric Cancer Positive for MET Amplification

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EML4-ALK陽性肺癌におけるシグナル伝達経路の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular-based approach for overcoming acquired resistance to EGFR tyrosine kinase inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the relationship between EGFR gene status and clinical effect and the elucidation of the resistance mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CD44 variant dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Survival outcome assessed according to tumor response and shrinkage pattern in patients with EGFR mutation-positive non-small cell lung cancer treated with gefitinib or erlotinib.2014

Author(s)

Journal Title

Data Source

[Journal Article] Multiplex genomic profiling of non–small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study2014

Author(s)

Journal Title

Data Source

[Journal Article] Development of ALK inhibitors and molecular diagnosis in ALK rearrangement–positive lung cancer.2014

Author(s)

Journal Title

Data Source

[Journal Article] Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement2014

Author(s)

Journal Title

Data Source

[Journal Article] Targeting MET Amplification as a New Oncogenic Driver.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MET amplification as a potential therapeutic target in gastric cancer.2013

Author(s)

Okamoto Isamu 岡本勇

OKAMOTO Isamu 岡本勇