Higasa Koichiro 日笠幸一郎

… Alternative Names

HIGASA Koichiro 日笠幸一郎

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Researcher Number	10419583
Affiliation (Current)	2025: 関西医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2025: 関西医科大学, 医学部, 教授 2017: 京都大学, スーパーグローバルコース医学生命系ユニット, 特定准教授 2009: 九州大学, 学術研究員 2009: Kyushu University, 統計解析研究チーム, 研究員 2008: Kyushu University, 生体防御医学研究所, 学術研究員 … More 2007: 九州大学, システム生命学府, 学術研究員 2007: Kyushu University, システム生命科学府, 学術研究員 2006: 九州大学, 生体防御医学研究所, 学術研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related / 基礎ゲノム科学 / Medical genome science / Complex Systems Disease Theory Except Principal Investigator Basic Section 49070:Immunology-related / Basic Section 45060:Applied anthropology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 49020:Human pathology-related / Basic Section 56010:Neurosurgery-related / Basic Section 52030:Psychiatry-related / Basic Section 48040:Medical biochemistry-related / Obstetrics and gynecology / Biological Sciences
Keywords	Principal Investigator ヒトゲノム構造多様性 / ハプロタイプ / 進化 / ゲノム / ヒトゲノム多様性 / オミックス解析 / 構造多型 Except Principal Investigator うつ病 / 代謝 / 細胞死 … More / ADP-ribosylation factor / T細胞 / 環境適応 / RNA-seq / エピゲノム / ネパール / チベット高地集団 / 高地適応 / 低圧低酸素 / シナプス分子 / 網羅解析 / 慢性疼痛 / 可塑的変化 / 治療効果 / 組織形態 / 腎癌 / 空間的遺伝子発現解析 / 全ゲノム解析 / ゲノム編集 / 二分脊椎症 / 適切なゴール / 長期評価 / 定量脳波 / サイトカイン / 双極性障害 / mtDNA / miRNA / ゲノム / プレシジョンメディスン / Pharmacogenomics / スプライシング / 尿酸取り込み実験 / 全ゲノム関連解析 / 佐渡PROSTコホート / ながはまコホート / レアバリアント / まれな変異 / 地域差 / 遺伝率 / 尿酸トランスポーター / 遺伝子フュージョン / カーネル / 統計検定 / コホート研究 / 痛風 / 尿酸値 / 分子進化 / 塩基置換モデル / 卵巣癌 / トランスレーショナルリサ―チ / ゲノム解析 / トランスレーショナルリサーチ / 卵巣明細胞癌 / 全身性エリテマトーデス(SLE) / ゲノムワイドな関連解析 / ゲノムワイドな確定ハプロタイプ / 胞状奇胎 / ソフトウェア「QSNP lite」 / 高精度アレル頻度決定 / SSCP解析 / 一塩基多型(SNP) / CpGアイランド / 家族性滲出性硝子体網膜症 / SLE / DHaploDB / 日本人確定ハプロタイプ / プールDNAによるゲノムワイド関連解析 / QSNPlite / 全胞状奇胎 / 確定ハプロタイプ / 一塩基多型 / PLACE-SSCP / 関連解析 / データベース / ハプロタイプ / SSCP / 自己免疫疾患 / 疾患関連解析 / SNP Less

ヒトゲノム未開拓領域探索法の確立Principal Investigator
- Principal Investigator
  
  日笠幸一郎
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Kansai Medical University
Development of a treatment effect prediction system based on architectural classification of renal cancer using spatial gene expression analysis
- Principal Investigator
  
  大江知里
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Osaka Metropolitan University
生体・細胞の全遺伝子発現変動に基づく急性低酸素応答を駆動する主要遺伝子群の解明
- Principal Investigator
  
  安河内彦輝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45060:Applied anthropology-related
- Research Institution
  Kansai Medical University
Arf経路を介したT細胞脂質代謝リプログラミングの分子基盤解明
- Principal Investigator
  
  住吉麻実
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kansai Medical University
オミックスと長期評価による適切なゴールを目指す気分障害の革新的治療の基盤構築
- Principal Investigator
  
  加藤正樹
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kansai Medical University
二分脊椎症と診断された患者およびその家族を対象とした原因遺伝子の探索
- Principal Investigator
  
  武田純一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kansai Medical University
中枢神経系の可塑的変化を病態基盤とする慢性疼痛とうつ病の新規分子機序の解明
- Principal Investigator
  
  片野泰代
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kansai Medical University
超精密個別化ゲノム解析法の開発による遺伝性疾患の病因病態解明Principal Investigator
- Principal Investigator
  
  日笠幸一郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Kansai Medical University
ながはまコホートおよび佐渡コホートのゲノム情報解析による、尿酸値関連変異の探索
- Principal Investigator
  
  三澤計治
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Yokohama City University
  Kansai Medical University
Development and Application of Omics Data Integrated Association Analysis Method Using Multi-Hierarchical Tensor FactorizationPrincipal Investigator
- Principal Investigator
  
  HIGASA Koichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Kansai Medical University
  Kyoto University
The genome analyses for advanced and recurrent ovarian clear cell carcinoma
- Principal Investigator
  
  Ikuo Konishi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Construction of high-dimensional Japanese genome reference sequences suitable for the search for disease-associated mutationsPrincipal Investigator
- Principal Investigator
  
  HIGASA Koichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical genome science
- Research Institution
  Kansai Medical University
  Kyoto University
Detection of Japanese Structural Variation Using Definitive Haplotype Data Obtained from Complete Hydatidiform Moles.Principal Investigator
- Principal Investigator
  
  HIGASA Koichiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  基礎ゲノム科学
- Research Institution
  Kyushu University
決定的ハプロタイプに基づく日本人ヒトゲノム中の自然選択領域の検出Principal Investigator
- Principal Investigator
  
  日笠幸一郎
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  基礎ゲノム科学
- Research Institution
  Kyushu University
DEVELOPMENT OF QUANTITATIVE METHODS FOR SINGLE NUCLEOTIDE POLYMORPHISMS ANALYSIS AND ITS APPLICATION IN MEDICAL GENETICS
- Principal Investigator
  
  TAHIRA Tomoko, HAYASHI Kenshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University

[Book] 遺伝子医学2022
- Author(s)
  日笠幸一郎
- Total Pages
  6
- Publisher
  メディカルドゥ
- ISBN
  9784909508171
- Data Source
  KAKENHI-PROJECT-23K21722
[Book] 最新医学 Vol.74(2)2019
- Author(s)
  川口修治、日笠幸一郎、山田亮、松田文彦
- Total Pages
  6
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-17K07255
[Book] HLA typing2018
- Author(s)
  Kawaguchi S, Higasa K, Yamada R, Matsuda F.
- Total Pages
  9
- Publisher
  Humana Press
- ISBN
  9781493985456
- Data Source
  KAKENHI-PROJECT-17K07255
[Book] Methods Mol Biol.(Estimation of SNP allele frequencies by SSCP analysis of pooled DNA)2009
- Author(s)
  Tahira T, Kukita Y, Higasa K, Okazaki Y, Yoshinaga A, Hayashi K.
- Data Source
  KAKENHI-PROJECT-20710147
[Journal Article] OLIG2 translocates to chromosomes during mitosis via a temperature downshift: A novel neural cold response of mitotic bookmarking.2024
- Author(s)
  Hayashi S, Seki-Omura R, Yamada S, Kamata T, Sato Y, Oe S, Koike T, Nakano Y, Iwashita H, Hirahara Y, Tanaka S, Sekijima T, Ito T, Yasukochi Y, Higasa K, Kitada M.
- Journal Title
  
  Gene
  
  Volume: 891 Pages: 7829-7829
- DOI
  10.1016/j.gene.2023.147829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06763, KAKENHI-PROJECT-22K06821, KAKENHI-PROJECT-22K06822, KAKENHI-PROJECT-21K20747, KAKENHI-PROJECT-22K20700, KAKENHI-PROJECT-23K21722
[Journal Article] Relationship between circulating mitochondrial DNA and microRNA in patients with major depression2023
- Author(s)
  Ogata Haruhiko、Higasa Koichiro、Kageyama Yuki、Tahara Hidetoshi、Shimamoto Akira、Takekita Yoshiteru、Koshikawa Yosuke、Nonen Shinpei、Kato Tadafumi、Kinoshita Toshihiko、Kato Masaki
- Journal Title
  
  Journal of Affective Disorders
  
  Volume: 339 Pages: 538-546
- DOI
  10.1016/j.jad.2023.07.073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07607, KAKENHI-PROJECT-23K07024, KAKENHI-PROJECT-23K21722
[Journal Article] Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy2023
- Author(s)
  Ueda Hiroko、Tran Quynh Thuy Huong、Tran Linh Nguyen Truc、Higasa Koichiro、Ikeda Yoshiki、Kondo Naoyuki、Hashiyada Masaki、Sato Chika、Sato Yoshinori、Tsukaguchi Hiroyasu
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 12003-12003
- DOI
  10.1038/s41598-023-38588-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16195, KAKENHI-PROJECT-20K08624, KAKENHI-PROJECT-23K07730, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-21K08224, KAKENHI-PROJECT-23K21722
[Journal Article] OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse2023
- Author(s)
  Hayashi Shinichi、Oe Souichi、Koike Taro、Seki‐Omura Ryohei、Nakano Yosuke、Hirahara Yukie、Tanaka Susumu、Ito Takeshi、Yasukochi Yoshiki、Higasa Koichiro、Kitada Masaaki
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: - Issue: 3 Pages: 303-317
- DOI
  10.1111/jnc.15746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06821, KAKENHI-PROJECT-22K06822, KAKENHI-PROJECT-21K20747, KAKENHI-PROJECT-18K06814, KAKENHI-PROJECT-19K06891, KAKENHI-PROJECT-21K06763, KAKENHI-PROJECT-23K21722
[Journal Article] Raman Multi-Omic Snapshot and Statistical Validation of Structural Differences between Herpes Simplex Type I and Epstein?Barr Viruses2023
- Author(s)
  Pezzotti Giuseppe、Ohgitani Eriko、Imamura Hayata、Ikegami Saki、Shin-Ya Masaharu、Adachi Tetsuya、Adachi Keiji、Yamamoto Toshiro、Kanamura Narisato、Marin Elia、Zhu Wenliang、Higasa Koichiro、Yasukochi Yoshiki、Okuma Kazu、Mazda Osam
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 21 Pages: 15567-15567
- DOI
  10.3390/ijms242115567
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10313, KAKENHI-PROJECT-23K09359, KAKENHI-PROJECT-23K10941, KAKENHI-PROJECT-23K21722
[Journal Article] Raman Fingerprints of SARS-CoV-2 Omicron Subvariants: Molecular Roots of Virological Characteristics and Evolutionary Directions2023
- Author(s)
  Pezzotti Giuseppe、Ohgitani Eriko、Fujita Yuki、Imamura Hayata、Pappone Francesco、Grillo Alfio、Nakashio Maiko、Shin-Ya Masaharu、Adachi Tetsuya、Yamamoto Toshiro、Kanamura Narisato、Marin Elia、Zhu Wenliang、Inaba Tohru、Tanino Yoko、Nukui Yoko、Higasa Koichiro、Yasukochi Yoshiki、Okuma Kazu、Mazda Osam
- Journal Title
  
  ACS Infectious Diseases
  
  Volume: 9 Issue: 11 Pages: 2226-2251
- DOI
  10.1021/acsinfecdis.3c00312
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09359, KAKENHI-PROJECT-23K09603, KAKENHI-PROJECT-23K10941, KAKENHI-PROJECT-23K21722
[Journal Article] Areas of Crush Nuclear Streaming Should Be Included as Tumor Content in the Era of Molecular Diagnostics2023
- Author(s)
  Noda Yuri、Yamaka Ryosuke、Atsumi Naho、Higasa Koichiro、Tsuta Koji
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 6 Pages: 1910-1910
- DOI
  10.3390/cancers15061910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21722
[Journal Article] Changes in Multiple microRNA Levels with Antidepressant Treatment Are Associated with Remission and Interact with Key Pathways: A Comprehensive microRNA Analysis2023
- Author(s)
  Funatsuki Toshiya、Ogata Haruhiko、Tahara Hidetoshi、Shimamoto Akira、Takekita Yoshiteru、Koshikawa Yosuke、Nonen Shinpei、Higasa Koichiro、Kinoshita Toshihiko、Kato Masaki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 15 Pages: 12199-12199
- DOI
  10.3390/ijms241512199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07607, KAKENHI-PROJECT-23K07024, KAKENHI-PROJECT-23K21722
[Journal Article] Adenoid Ameloblastoma with BRAF p.V600E Mutation Revealing Ameloblastomatous Origin: A First Case Report2023
- Author(s)
  Noda Yuri、Sawada Shunsuke、Sakagami Tomofumi、Kojima Yuka、Higasa Koichiro、Tsuta Koji
- Journal Title
  
  Head and Neck Pathology
  
  Volume: 17 Issue: 3 Pages: 788-792
- DOI
  10.1007/s12105-023-01555-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21722
[Journal Article] Successful pregnancy and delivery in a young-onset hypertrophic cardiomyopathy patient with a novel doublet-base substitution in the MYH7 gene2023
- Author(s)
  Miyawaki Norihisa、Toyota Toshiaki、Higasa Koichiro、Nakamura Tomoyuki、Furukawa Yutaka
- Journal Title
  
  Journal of Cardiology Cases
  
  Volume: 27 Issue: 1 Pages: 8-11
- DOI
  10.1016/j.jccase.2022.09.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19361, KAKENHI-PROJECT-23K21722, KAKENHI-PROJECT-23K24098
[Journal Article] Dysbiosis of the gut microbiota as a susceptibility factor for Kawasaki disease2023
- Author(s)
  Teramoto Yoshiki、Akagawa Shohei、Hori Shin-ichiro、Tsuji Shoji、Higasa Koichiro、Kaneko Kazunari
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1268453-1268453
- DOI
  10.3389/fimmu.2023.1268453
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15876, KAKENHI-PROJECT-23K21722
[Journal Article] Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase2023
- Author(s)
  Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda, and Tasuku Honjo
- Journal Title
  
  PNAS USA
  
  Volume: 120 (18) e2216918120 h Issue: 18
- DOI
  10.1073/pnas.2216918120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00449, KAKENHI-PROJECT-23K21722
[Journal Article] Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin12023
- Author(s)
  Ueda Yoshihiro、Higasa Koichiro、Kamioka Yuji、Kondo Naoyuki、Horitani Shunsuke、Ikeda Yoshiki、Bergmeier Wolfgang、Fukui Yoshinori、Kinashi Tatsuo
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 8 Pages: 107292-107292
- DOI
  10.1016/j.isci.2023.107292
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06601, KAKENHI-PROJECT-20K07331, KAKENHI-PROJECT-21K06181, KAKENHI-PROJECT-23K21722, KAKENHI-PROJECT-23K23886
[Journal Article] Deep learning-based predictions of clear and eosinophilic phenotypes in clear cell renal cell carcinoma2023
- Author(s)
  Ohe C, Yoshida T, Amin MB, Uno R, Atsumi N, Yasukochi Y, Ikeda J, Nakamoto T, Noda Y, Kinoshita H, Tsuta K, Higasa K.
- Journal Title
  
  Human Pathology
  
  Volume: 131 Pages: 68-78
- DOI
  10.1016/j.humpath.2022.11.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16875, KAKENHI-PROJECT-23K21722, KAKENHI-PROJECT-21K09362
[Journal Article] Histologic-based tumor-associated immune cells status in clear cell renal cell carcinoma correlates with gene signatures related to cancer immunity and clinical outcomes2022
- Author(s)
  Ohe C, Yoshida T, Ikeda J, Tsuzuki T, Ohashi R, Ohsugi H, Atsumi N, Yamaka R, Saito R, Yasukochi Y, Higasa K, Kinoshita H and Tsuta K.
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 2 Pages: 323-323
- DOI
  10.3390/biomedicines10020323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16875, KAKENHI-PROJECT-20K16457, KAKENHI-PROJECT-23K21722
[Journal Article] Accelerated Angiogenesis of Human Umbilical Vein Endothelial Cells Under Negative Pressure Was Associated With the Regulation of Gene Expression Involved in the Proliferation and Migration2022
- Author(s)
  Fukui Michika、Matsuoka Yuki、Taketani Shigeru、Higasa Koichiro、Hihara Masakatsu、Kuro Atsuyuki、Kakudo Natsuko
- Journal Title
  
  Annals of Plastic Surgery
  
  Volume: 89 Issue: 6 Pages: e51-e59
- DOI
  10.1097/sap.0000000000003298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21722
[Journal Article] PBRM1 Immunohistochemical Expression Profile Correlates with Histomorphological Features and Endothelial Expression of Tumor Vasculature for Clear Cell Renal Cell Carcinoma2022
- Author(s)
  Saiga K*, Ohe C* (*equally contributed), Yoshida T, Ohsugi H, Ikeda J, Atsumi N, Noda Y, Yasukochi Y, Higasa K, Taniguchi H, Kinoshita H, Tsuta K.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 14 Issue: 4 Pages: 1062-1062
- DOI
  10.3390/cancers14041062
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16875, KAKENHI-PROJECT-20K16457, KAKENHI-PROJECT-23K21722
[Journal Article] Multidimensional analyses of the pathomechanism caused by the non-catalytic GNE variant, c.620A>T, in patients with GNE myopathy2022
- Author(s)
  Yoshioka Wakako、Iida Aritoshi、Sonehara Kyuto、Yamamoto Kazuki、Oya Yasushi、Mori-Yoshimura Madoka、Kurashige Takashi、Okubo Mariko、Ogawa Megumu、Matsuda Fumihiko、Higasa Koichiro、Hayashi Shinichiro、Nakamura Harumasa、Sekijima Masakazu、Okada Yukinori、Noguchi Satoru、Nishino Ichizo
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 21806-21806
- DOI
  10.1038/s41598-022-26419-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06961, KAKENHI-PROJECT-20H00620, KAKENHI-PROJECT-23K21722
[Journal Article] Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways.2022
- Author(s)
  Kato M, Ogata H, Tahara H, Shimamoto A, Takekita Y, Koshikawa Y, Nishida K, Nonen S, Higasa K, Kinoshita T.
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 23 Issue: 7 Pages: 3873-3873
- DOI
  10.3390/ijms23073873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07607, KAKENHI-PROJECT-23K21722
[Journal Article] Development and validation of a vascularity-based architectural classification for clear cell renal cell carcinoma: correlation with conventional pathological prognostic factors, gene expression patterns, and clinical outcomes2021
- Author(s)
  Ohe C, Yoshida T, Amin MB, Atsumi N, Ikeda J, Saiga K, Noda Y, Yasukochi Y, Ohashi R, Ohsugi H, Higasa K, Kinoshita H and Tsuta K
- Journal Title
  
  Mod Pathol
  
  Volume: － Issue: 6 Pages: 816-824
- DOI
  10.1038/s41379-021-00982-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16875, KAKENHI-PROJECT-20K16457, KAKENHI-PROJECT-23K21722
[Journal Article] Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation2021
- Author(s)
  Matsuo Tomohiko、Isosaka Tomoko、Hayashi Yuichiro、Tang Lijun、Doi Akihiro、Yasuda Aiko、Hayashi Mikio、Lee Chia-Ying、Cao Liqin、Kutsuna Natsumaro、Matsunaga Sachihiro、Matsuda Takeshi、Yao Ikuko、Setou Mitsuyoshi、Kanagawa Dai、Higasa Koichiro、Ikawa Masahito、Liu Qinghua、Kobayakawa Reiko、Kobayakawa Ko
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 2074-2074
- DOI
  10.1038/s41467-021-22205-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06773, KAKENHI-PROJECT-20K06738, KAKENHI-PROJECT-18H02546, KAKENHI-PROJECT-20K09337, KAKENHI-PLANNED-20H05911, KAKENHI-PROJECT-19H03259, KAKENHI-PROJECT-20K07715, KAKENHI-PROJECT-20K09400, KAKENHI-PROJECT-21K09191, KAKENHI-PROJECT-19K16933, KAKENHI-PROJECT-23K21722, KAKENHI-PROJECT-20K20578, KAKENHI-PUBLICLY-20H04849
[Journal Article] PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma2021
- Author(s)
  Kitamura S, Yamaguchi K, Murakami R, Furutake Y, Higasa K, Abiko K, Hamanishi J, Baba T, Matsumura N, Mandai M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 11 Pages: 4627-4640
- DOI
  10.1111/cas.15125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09287, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-20K21665, KAKENHI-PROJECT-23K21722
[Journal Article] Genotype-Phenotype Correlations in RP1-Associated Retinal Dystrophies: A Multi-Center Cohort Study in JAPAN2021
- Author(s)
  Mizobuchi Kei、Hayashi Takaaki、Oishi Noriko、Kubota Daiki、Kameya Shuhei、Higasa Koichiro、Futami Takuma、Kondo Hiroyuki、Hosono Katsuhiro、Kurata Kentaro、Hotta Yoshihiro、Yoshitake Kazutoshi、Iwata Takeshi、Matsuura Tomokazu、Nakano Tadashi
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Issue: 11 Pages: 2265-2265
- DOI
  10.3390/jcm10112265
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09825, KAKENHI-PROJECT-21K09756, KAKENHI-PROJECT-23K21722
[Journal Article] Eosinophilic features in clear cell renal cell carcinoma correlate with outcomes of immune checkpoint and angiogenesis blockade2021
- Author(s)
  Yoshida T, Ohe C, Ikeda J, Atsumi N, Ohsugi H, Sugi M, Higasa K, Saito R, Tsuta K, Matsuda T, Kinoshita H.
- Journal Title
  
  J Immunother Cancer .
  
  Volume: 9 Issue: 9 Pages: e002922-e002922
- DOI
  10.1136/jitc-2021-002922
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07601, KAKENHI-PROJECT-19K16875, KAKENHI-PROJECT-23K21722
[Journal Article] Combined Single Nucleotide Variants of ORAI1 and BLK in a Child with Refractory Kawasaki Disease2021
- Author(s)
  Kanda Saki、Fujii Yoshimitsu、Hori Shin-ichiro、Ohmachi Taichi、Yoshimura Ken、Higasa Koichiro、Kaneko Kazunari
- Journal Title
  
  Children
  
  Volume: 8 Issue: 6 Pages: 433-433
- DOI
  10.3390/children8060433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21722
[Journal Article] Population dynamics in the Japanese Archipelago since the Pleistocene revealed by the complete mitochondrial genome sequences.2021
- Author(s)
  Mizuno, F., Gojobori, J., Kumagai, M., Baba, H., Taniguchi, Y., Kondo, O., Matsushita, M., Matsushita, T., Matsuda, F., Higasa, K., Hayashi, M., Wang, L., Kurosaki, K. and Ueda, S.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-021-91357-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00939, KAKENHI-PLANNED-18H05508, KAKENHI-PLANNED-18H05511, KAKENHI-PUBLICLY-21H00350, KAKENHI-PROJECT-21H04363, KAKENHI-PROJECT-20K15884, KAKENHI-PLANNED-20H05820, KAKENHI-PROJECT-21H04983, KAKENHI-PLANNED-17H06381, KAKENHI-PLANNED-19H05737, KAKENHI-PROJECT-23K21722
[Journal Article] Positive renal familial history in IgA nephropathy is associated with worse renal outcomes: a single-center longitudinal study2021
- Author(s)
  Sato Yoshinori、Tsukaguchi Hiroyasu、Higasa Koichiro、Kawata Naoto、Inui Kiyoko、Linh Tran Nguyen Truc、Quynh Tran Thuy Huong、Yoshihiko Inoue、Koiwa Fumihiko、Yoshimura Ashio
- Journal Title
  
  BMC Nephrology
  
  Volume: 22 Issue: 1 Pages: 490-502
- DOI
  10.1186/s12882-021-02425-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09719, KAKENHI-PROJECT-20K08624, KAKENHI-PROJECT-21K16195, KAKENHI-PROJECT-23K21722
[Journal Article] Genome-wide association study of individual differences of human lymphocyte profiles using large-scale cytometry data2020
- Author(s)
  Okada Daigo、Nakamura Naotoshi、Setoh Kazuya、Kawaguchi Takahisa、Higasa Koichiro、Tabara Yasuharu、Matsuda Fumihiko、Yamada Ryo
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 66 Issue: 6 Pages: 557-567
- DOI
  10.1038/s10038-020-00874-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J14816, KAKENHI-PROJECT-23K21722
[Journal Article] Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population2019
- Author(s)
  Imaizumi Akira、Adachi Yusuke、Kawaguchi Takahisa、Higasa Koichiro、Tabara Yasuharu、Sonomura Kazuhiro、Sato Taka-aki、Takahashi Meiko、Mizukoshi Toshimi、Yoshida Hiro-o、Kageyama Naoko、Okamoto Chisato、Takasu Mariko、Mori Maiko、Noguchi Yasushi、Shimba Nobuhisa、Miyano Hiroshi、Yamada Ryo、Matsuda Fumihiko
- Journal Title
  
  European Journal of Human Genetics
  
  Volume: 27 Issue: 4 Pages: 621-630
- DOI
  10.1038/s41431-018-0296-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04123, KAKENHI-PROJECT-17KT0125
[Journal Article] Legacy Data Confound Genomics Studies2019
- Author(s)
  Anderson-Trocme Luke、Farouni Rick、Bourgey Mathieu、Kamatani Yoichiro、Higasa Koichiro、Seo Jeong-Sun、Kim Changhoon、Matsuda Fumihiko、Gravel Simon
- Journal Title
  
  Molecular Biology and Evolution
  
  Volume: 37 Issue: 1 Pages: 2-10
- DOI
  10.1093/molbev/msz201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07255
[Journal Article] Association of ALPL variants with serum alkaline phosphatase and bone traits in the general Japanese population: The Nagahama Study2019
- Author(s)
  Nagata Miho、Setoh Kazuya、Takahashi Meiko、Higasa Koichiro、Kawaguchi Takahisa、Kawasaki Hidenori、Wada Takahito、Watanabe Atsushi、Sawai Hideaki、Tabara Yasuharu、Yamada Takahiro、Matsuda Fumihiko、Kosugi Shinji
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65 Issue: 3 Pages: 337-343
- DOI
  10.1038/s10038-019-0712-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07411, KAKENHI-PROJECT-17KT0125
[Journal Article] IgG4-related disease in the Japanese population: a genome-wide association study2019
- Author(s)
  Terao, C. et al.
- Journal Title
  
  The Lancet Rheumatology
  
  Volume: 1 Issue: 1 Pages: e14-e22
- DOI
  10.1016/s2665-9913(19)30006-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07349, KAKENHI-PROJECT-17KT0125
[Journal Article] Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells2018
- Author(s)
  Yamaura Tadayoshi、Miyoshi Hiroyuki、Maekawa Hisatsugu、Morimoto Tomonori、Yamamoto Takehito、Kakizaki Fumihiko、Higasa Koichiro、Kawada Kenji、Matsuda Fumihiko、Sakai Yoshiharu、Taketo M. Mark
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 101 Pages: 37534-37548
- DOI
  10.18632/oncotarget.26495
- NAID
  120006546167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0125
[Journal Article] Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project2018
- Author(s)
  Yasuda Jun、et al.,
- Journal Title
  
  BMC Genomics
  
  Volume: 19 Issue: 1 Pages: 551-551
- DOI
  10.1186/s12864-018-4942-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K07255, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-16K08638
[Journal Article] Risk allele of the FZD4 gene for familial exudative vitreoretinopathy2018
- Author(s)
  Kondo H, Uchio E, Kusaka S, Higasa K
- Journal Title
  
  Ophthalmic Genet
  
  Volume: 39 Issue: 3 Pages: 405-406
- DOI
  10.1080/13816810.2017.1401090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10911, KAKENHI-PROJECT-17K11441, KAKENHI-PROJECT-17K07255
[Journal Article] Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy2018
- Author(s)
  Ishiura Hiroyuki、Doi Koichiro、Mitsui Jun、Yoshimura Jun、Matsukawa Miho Kawabe、Takahashi Yuji、Date Hidetoshi、Matsukawa Takashi、Shimizu Jun、Koh Kishin、Takiyama Yoshihisa、Goto Jun、Morishita Shinichi、Tsuji Shoji
- Journal Title
  
  Nature Genetics
  
  Volume: 50 Issue: 4 Pages: 581-590
- DOI
  10.1038/s41588-018-0067-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17772, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-PROJECT-15H06161, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05874, KAKENHI-PROJECT-17H05085, KAKENHI-PROJECT-16K09670, KAKENHI-PROJECT-16K14571, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17K07255, KAKENHI-PROJECT-17K09798, KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-18K07542, KAKENHI-PROJECT-16K09681
[Journal Article] HLA-HD: An accurate HLA typing algorithm for next-generation sequencing data2017
- Author(s)
  Kawaguchi Shuji, Higasa Koichiro, Shimizu Masakazu, Yamada Ryo, Matsuda Fumihiko
- Journal Title
  
  Human Mutation
  
  Volume: 38 Issue: 7 Pages: 788-797
- DOI
  10.1002/humu.23230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18474, KAKENHI-PROJECT-17K07255
[Journal Article] A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension.2017
- Author(s)
  Higasa K, Ogawa A, Terao C, Shimizu M, Kosugi S, Yamada R, Date H, Matsubara H, Matsuda F.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 17 Issue: 1 Pages: 57-57
- DOI
  10.1186/s12890-017-0400-z
- NAID
  120006305759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09488, KAKENHI-PROJECT-17KT0125, KAKENHI-PROJECT-15K08646
[Journal Article] Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks.2017
- Author(s)
  Murakami R, Matsumura N, Brown JB, Higasa K, Tsutsumi T, Kamada M, Abou-Taleb H, Hosoe Y, Kitamura S, Yamaguchi K, Abiko K, Hamanishi J, Baba T, Koshiyama M, Okuno Y, Yamada R, Matsuda F, Konishi I, Mandai M.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 187 Issue: 10 Pages: 2246-2258
- DOI
  10.1016/j.ajpath.2017.06.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0125, KAKENHI-PROJECT-17K19591, KAKENHI-PROJECT-17H01587, KAKENHI-PROJECT-16K15707
[Journal Article] A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events.2010
- Author(s)
  Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K.
- Journal Title
  
  Am. J. Hum. Genet. (in press)
- NAID
  120002239171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710147
[Journal Article] A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events.2010
- Author(s)
  Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K.
- Journal Title
  
  Am.J.Hum.Genet. 86(6)
  
  Pages: 918-928
- NAID
  120002239171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Evaluation of haplotype inference using definitive haplotype data obtained from complete hydatidiform moles, and its significance for the analyses of positively selected regions.2009
- Author(s)
  Higasa K, Kukita Y, Kato K, Wake N, Tahira T, Hayashi K.
- Journal Title
  
  PLoS Genetics 5(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Evaluation of haplotype inference using definitive haplotype data obtained from complete hydatidiform moles, and its significance for the analyses of positively selected regions.2009
- Author(s)
  Higasa K, Kukita Y, Kato K, Wake N, Tahira T, Hayashi K.
- Journal Title
  
  PLoS Genet. 5(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710147
[Journal Article] Evaluation of haplotype inference using definitive haplotype data obtained from complete hydatidiform moles, and its significance for the analyses of positively selected regions2009
- Author(s)
  Higasa K, et al.
- Journal Title
  
  PLoS Genetics 5(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710147
[Journal Article] Evaluation of haplotype inference using definitive haplotype data obtained from complete hydatidiform moles, and its significance for the analyses of positively selected regions.2009
- Author(s)
  Higasa K, et al.
- Journal Title
  
  PLoS Genetics
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Evaluation of haplotype inference using definitive haplotype data obtained from complete hydatidiform moles, and its significance for the analyses of positively selected reaions2009
- Author(s)
  Higasa K, et.al.
- Journal Title
  
  PLoS Genetics 5(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Estimation of SNP allele frequencies by SSCP analysis of poolepooleolepooleleNA.2009
- Author(s)
  Tahira T, Kukita Y, Higasa K, Okazaki Y, Yoshinaga A, Hayashi K.
- Journal Title
  
  Methods in Molecular Biology 578
  
  Pages: 193-207
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Narrowing of the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis.2008
- Author(s)
  Guan Y, Hata N, Kuga D, Yoshimoto K, Mizoguchi M, Shono T, Suzuki SO, Tahira T, Kukita Y, Higasa K, Yokoyama N, Nagata S, Iwaki T, Sasaki T, Hayashi K.
- Journal Title
  
  Int J Cancer 15,122(8)
  
  Pages: 1820-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710147
[Journal Article] Narrowing the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis.2008
- Author(s)
  Guan Y, Hata N, Kuga D, Yoshimoto K, Mizoguchi M, Shono T, Suzuki S, Tahira T, Kukita Y, Higasa K, Yokoyama N, Nagata S, Iwaki T, Sasaki T, Hayashi K.
- Journal Title
  
  Int.J.Cancer 122(8)
  
  Pages: 1820-1826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] D-HaploDB : a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples.2007
- Author(s)
  Higasa K, Miyatake K, Kukita Y, Tahira T, Hayashi K.
- Journal Title
  
  Nucleic Acids Res. 35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] D-HaploDB : a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples.2007
- Author(s)
  Higasa K, et al.
- Journal Title
  
  Nucleic Acids Res. 35
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] D-HaploDB : a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples.2007
- Author(s)
  Higasa K et al.
- Journal Title
  
  Nucleic Acids Research 35
- Data Source
  KAKENHI-PROJECT-18710163
[Journal Article] Periodicity of SNP distribution around transcription start sites2006
- Author(s)
  Higasa K, Hiyashi K
- Journal Title
  
  BMC Genomics 7
  
  Pages: 66-66
- Data Source
  KAKENHI-PROJECT-18710163
[Journal Article] QSNPlite, a software system for quantitative analysis of SNPs based on capillary array SSCP analysis.2006
- Author(s)
  Tahira T, Okazaki Y, Miura K, Yoshinaga A, Masumoto K, Higasa K, Kukita Y, Hayashi K.
- Journal Title
  
  Electrophoresis 27(19)
  
  Pages: 3869-3878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Periodicity of SNP distribution around transcription start sites.2006
- Author(s)
  Higasa K, Hayashi K.
- Journal Title
  
  BMC Genomics 7
  
  Pages: 66-66
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Periodicity of SNP distribution around transcription start sites.2006
- Author(s)
  Higasa K, Hayashi K
- Journal Title
  
  BMC Genomics 7
  
  Pages: 66-66
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Allelic Losses of Chromosome 10 in Glioma Tissues Detected by Quantitative Single-Strand Conformation Polymorphism Analysis.2006
- Author(s)
  Hata N, Yoshimoto K, Yokoyama N, Mizoguchi M, Shono T, Guan Y, Tahira T, Kukita Y, Higasa K, Nagata S, Iwaki T, Sasaki T, Hayashi K.
- Journal Title
  
  Clin.Chem 52(3)
  
  Pages: 370-378
- NAID
  120000986935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] dbQSNP : a database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism- based method.2005
- Author(s)
  Tahira T, Baba S, Higasa K, Kukita Y, Suzuki Y, Sugano S, Hayashi K.
- Journal Title
  
  Human Mutation 26(2)
  
  Pages: 69-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Journal Article] Genome-wide definitive haplotypes determined using a collection of complete hydatidiform moles.2005
- Author(s)
  Kukita Y, Miyatake K, Stokowski R, Hinds D, Higasa K, Wake N, Hirakawa T, Kato H, Matsuda T, Pant K, Cox D, Tahira T, Hayashi K.
- Journal Title
  
  Genome Res. 15(11)
  
  Pages: 1511-1518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019051
[Presentation] マウス脊髄損傷へのイモリ型脊髄再生原理の導入へ向けて2023
- Author(s)
  林真一、関亮平、大江総一、小池太郎、中野洋輔、伊藤健、安河内彦輝、日笠幸一郎、北田容章
- Organizer
  両生類研究センターバイオリソース棟落成記念シンポジウム
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 本邦のうつ病患者における疾患発症に関するゲノムワイド関連解析2023
- Author(s)
  島本優太郎, 安河内彦輝, 村瀬雄士, 山本敦子, 内藤みなみ, 越川陽介, 舩槻紀也, 緒方治彦, 嶽北佳輝, 木下利彦, 日笠幸一郎, 加藤正樹
- Organizer
  第20回日本うつ病学会総会/第39回日本ストレス学会・学術総会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 本邦のうつ病患者における疾患発症、薬物治療反応性に関するゲノムワイド関連解析2023
- Author(s)
  島本優太郎, 安河内彦輝, 村瀬雄士, 越川陽介, 舩槻紀也, 緒方治彦, 嶽北佳輝, 木下利彦, 日笠幸一郎, 加藤正樹
- Organizer
  第45回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 本邦のうつ病患者における疾患発症、薬物治療反応性に関するゲノムワイド関連解析（GWAS）2023
- Author(s)
  島本優太郎、安河内彦輝、村瀬雄士、越川陽介、舩槻紀也、緒方治彦、嶽北佳輝、木下利彦、日笠幸一郎、加藤正樹
- Organizer
  第45回日本生物学的精神医学会総会
- Data Source
  KAKENHI-PROJECT-22K07607
[Presentation] マウス脊髄損傷へのイモリ型脊髄再生原理の導入へ向けて2023
- Author(s)
  林真一、関亮平、大江総一、小池太郎、中野洋輔、伊藤健、安河内彦輝、日笠幸一郎、北田容章
- Organizer
  日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] マウス脊髄損傷へのイモリ型脊髄再生原理の導入へ向けて2023
- Author(s)
  林真一、関亮平、大江総一、小池太郎、中野洋輔、伊藤健、安河内彦輝、日笠幸一郎、北田容章
- Organizer
  日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] ゲノム解析に基づく北河内医療圏における新型コロナウイルス変異株の時空間分布解2023
- Author(s)
  安河内彦輝，下埜敬紀，神田靖士，上野孝治，宮下修行，甲田勝康，藤澤順一，大隈和，神田晃，西山利正，大橋順，中森靖，日笠幸一郎
- Organizer
  日本進化学会第25回沖縄大会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 全ゲノム解析を用いた難治性脳形成障害の遺伝子異常検索2023
- Author(s)
  埜中正博, 日笠浩一郎, 小森裕美子, 磯﨑春奈, 淺井昭雄
- Organizer
  第51回日本小児神経外科学会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 全ゲノム解析にて特定した tubulin 遺伝子の変異を有する難治性脳形成障害2023
- Author(s)
  埜中正博, 日笠幸一郎, 小森裕美子, 磯﨑春奈, 淺井昭雄
- Organizer
  第65回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] Multi-dimensional analyses of the pathomechanism of GNE myopathy with non-catalytic site variant, GNE: c.620A>T2022
- Author(s)
  Wakako Yoshioka, Aritoshi Iida, Kyuto Sonehara, Kazuki Yamamoto, Yasushi Oya, Madoka Mori-Yoshimura, Takashi Kurashige, Mariko Okubo, Megumu Ogawa, Fumihiko Matsuda, Koichiro Higasa, Shinichiro Hayashi, Harumasa Nakamura, Masakazu Sekijima, Yukinori Okada, Satoru Noguchi, Ichizo Nishino
- Organizer
  Myology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 本邦のうつ病患者と健常者サンプルを用いたゲノムワイド関連解析（GWAS）2022
- Author(s)
  島本優太郎, 安河内彦輝, 村瀬雄士, 越川陽介, 舩槻紀也, 緒方治彦, 木下利彦, 日笠幸一郎, 加藤正樹
- Organizer
  第19回日本うつ病学会総会／第5回日本うつ病リワーク協会年次大会【合同開催】
- Data Source
  KAKENHI-PROJECT-22K07607
[Presentation] Gut microbiota as a factor underlying Kawasaki disease susceptibility2022
- Author(s)
  Yoshiki Teramoto , Shohei Akagawa , Yuko Akagawa , Shin-ichiro Hori , Sohsaku Yamanouchi , Shoji Tsuji , Koichiro Higasa , Kazunari Kaneko
- Organizer
  International Human Microbiome Consortium 9thCongress
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 本邦のうつ病患者における疾患発症、重症度、薬物治療反応性に関するゲノムワイド関連解析（GWAS)2022
- Author(s)
  島本優太郎, 安河内彦輝, 村瀬雄士, 越川陽介, 舩槻紀也, 緒方治彦, 嶽北佳輝, 木下利彦, 日笠幸一郎, 加藤正樹
- Organizer
  BPCNPNPPP4学会合同年会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways2022
- Author(s)
  Masaki Kato, Haruhiko Ogata, Hidetoshi Tahara, Akira Shimamoto, Yoshiteru Takekita, Yosuke Koshikawa, Keiichiro Nishida, Shinpei Nonen, Koichiro Higasa, Toshihiko Kinoshita
- Organizer
  World Congress of Psychiatric Genetics (WCPG 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07607
[Presentation] 本邦のうつ病患者と健常者サンプルを用いたゲノムワイド関連解析（GWAS）2022
- Author(s)
  島本優太郎, 安河内彦輝, 村瀬雄士, 越川陽介, 舩槻紀也, 緒方治彦, 木下利彦, 日笠幸一郎, 加藤正樹
- Organizer
  第19回日本うつ病学会総会／第5回日本うつ病リワーク協会年次大会【合同開催】
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 本邦のうつ病患者における疾患発症、薬物治療反応性に関するゲノムワイド関連解析（GWAS)2022
- Author(s)
  島本優太郎, 安河内彦輝, 村瀬雄士, 越川陽介, 舩槻紀也, 緒方治彦, 嶽北佳輝, 木下利彦, 日笠幸一郎, 加藤正樹
- Organizer
  第41回躁うつ病の薬理・生化学的研究懇話会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] GNE pathogenic variant p.D207V rarely develops myopathy in homozygote2021
- Author(s)
  Yoshioka W, Sonehara K, Iida A, Oya Y, Kurashige T, Okubo M, Ogawa M, Matsuda F, Higasa K, Mori-Yoshimura M, Nakamura H, Hayashi S, Okada Y, Noguchi S, Nishino I.
- Organizer
  World Muscle Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] Novel double missense mutation at the same codon in the MYH7 gene in a patient with hypertrophic cardiomyopathy.2021
- Author(s)
  Miyawaki N, Toyota T, Kim K, Kitai T, Kaji S, Higasa K, Nakamura T, Furukawa Y.
- Organizer
  European Society of Cardiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 日本人におけるRP1関連網膜症の遺伝的、臨床的特徴について2021
- Author(s)
  溝渕圭、林孝彰、林孝彰、大石典子、亀谷修平、日笠幸一郎、二見拓磨、近藤寛之、細野克博、倉田健太郎、堀田喜裕、吉武和敏、岩田岳、中野匡
- Organizer
  第125回日本眼科学会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] 陰圧が血管内皮細胞（HUVEC）に与える影響：次世代シーケンサーを用いた遺伝子発現の網羅的解析2021
- Author(s)
  福井充香、日笠幸一郎、竹谷茂、光井俊人、松岡祐貴、日原正勝、孫仲鑫、覚道奈津子
- Organizer
  第30回日本形成外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21722
[Presentation] GNEミオパチー p.D207V変異は軽症型変異であり、ホモ接合体では極めて稀にしか発症しない2019
- Author(s)
  吉岡和香子、飯田有俊、岡田随象、大矢寧、大久保真理子、小川恵、松田文彦、日笠幸一郎、森まどか、中村治雅、林晋一郎、野口悟、西野一三
- Organizer
  日本筋学会第5回学術集会
- Data Source
  KAKENHI-PROJECT-17KT0125
[Presentation] Visualization of comprehensively changes in whole cell subsets after influenza vaccination2019
- Author(s)
  Okada D, Nakamura N, Setoh K, Kawaguchi T, Narahara M, Higasa K, Tabara Y, Matsuda F, Yamada R
- Organizer
  VIZBI 2019 - the 10th Visualizing biological data
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0125
[Presentation] MicroRNA Profiles as Predictor of Phenotrypic Features of the Therapeutic Effect of Mirtazapine and SSRI in Mdd Patients2019
- Author(s)
  Kato M, Ogata H, Higasa K, Tahara H, Shimamoto A, Tkekita Y, Bandou H, Kosikawa Y, Sakai S, Nishida K, Nonen S, Kinoshita T
- Organizer
  26th World Congress of Psychiatric Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07255
[Presentation] THE RELATIONSHIP BETWEEN CIRCULATING MITOCHONDRIAL DNA AND MIRNA IN PATIENTS WITH MAJOR DEPRESSION2019
- Author(s)
  Ogata H, Higasa K, Kato T, Kageyama Y, Tahara H, Shimamoto A, Takekita Y, Bando H, Koshikawa Y, Sakai S, Nishida K, Nonen S, Kinoshita T, Kato M
- Organizer
  XXVIIth World Congress of Psychiatric Genetics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07255
[Presentation] 次世代シークエンサーと国際データベースを用いた高効率・高精度なHLA遺伝子群の包括的タイピング技術の確立2018
- Author(s)
  川口修治、日笠幸一郎、清水正和、山田亮、松田文彦
- Organizer
  第63回日本人類遺伝学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07255
[Presentation] 人工知能を用いたデータマイニングと全ゲノムデータ解析技術の融合によるメンデル遺伝性疾患の新規疾患遺伝子同定への試み2018
- Author(s)
  川口修治、徳増玲太郎、日笠幸一郎、高野敦司、松田文彦
- Organizer
  第63回日本人類遺伝学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07255
[Presentation] MAFB転写因子変異によるDuan眼球後退症候群を合併する巣状分節性糸球体硬化症発症の分子機序2018
- Author(s)
  佐藤芳憲、塚口裕康、小岩文彦、日笠幸一郎、松田文彦、高橋智
- Organizer
  第63回日本人類遺伝学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0125
[Presentation] Frequency of c.620A>T homozygotes is extremely low in Japanese GNE myopathy patients: What is determining the pathogenicity?2018
- Author(s)
  Yoshioka W, Okubo M, Ogawa M, Matsuda F, Higasa K, Mori-Yoshimura M, Oya Y, Kimura E, Nakamura H, Hayashi S, Iida A, Noguchi S, Nishino I
- Organizer
  International conference at Institut des Hautes Etudes Scientifiques (IHES)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0125
[Presentation] 大規模シングルセル発現データを用いた細胞集団プロファイル全体の異同の解析2018
- Author(s)
  岡田大瑚、中村直俊、瀬藤和也、川口喬久、奈良原舞子、日笠幸一郎、田原康玄、松田文彦、山田亮
- Organizer
  第42回日本分子生物学会年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0125
[Presentation] 一般地域住民における低ホスファターゼ症の未診断罹患者および非発症キャリアの研究：ながはまスタディ2018
- Author(s)
  永田美保、山田崇弘、十川麗美、馬場遥香、川崎秀徳、和田敬仁、澤井英明、瀬藤和也、川口喬久、日笠幸一郎、中山健夫、田原康玄、松田文彦、小杉眞司
- Organizer
  第63回日本人類遺伝学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0125
[Presentation] Development of AI technology to identify unknown causal genes and its integration in platform based on registry system.2018
- Author(s)
  Kawaguchi S, Tokumasu R, Numa S, Higasa K, Oishi A, Miyake M, Oishi M, Kamatani Y, Tsujikawa A, Takano A, Matsuda F
- Organizer
  International conference at Institut des Hautes Etudes Scientifiques (IHES)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07255
[Presentation] 胞状奇胎から得られた確定ハプロタイプに基づく推定ハプロタイプの評価と自然選択解析への影響2009
- Author(s)
  日笠幸一郎
- Organizer
  日本人類遺伝学会
- Place of Presentation
  日本・東京
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-20710147
[Presentation] 胞状奇胎から得られた確定ハプロタイプに基づく推定ハプロタイプの評価と自然選択解析への影響2009
- Author(s)
  日笠幸一郎、久木田洋児、田平知子、林健志
- Organizer
  日本人類遺伝学会、第54回大会
- Place of Presentation
  日本・東京
- Year and Date
  2009-09-23
- Data Source
  KAKENHI-PROJECT-20710147
[Presentation] Impact of definitive haplotypes for detecting recent positive selection2008
- Author(s)
  日笠幸一郎
- Organizer
  2008 Cold Spring Harbor Laboratory Meeting on The Biology of Genomes
- Place of Presentation
  New York, USA
- Year and Date
  2008-05-06
- Data Source
  KAKENHI-PROJECT-20710147
[Presentation] Impact of definitive haplotypes for detecting recent positive selection.2008
- Author(s)
  Higasa K, Kukita Y, Tahira T, Hayashi K
- Organizer
  Cold Spring Harbor Laboratory Meeting on The Biology of Genomes
- Place of Presentation
  New York, USA
- Year and Date
  2008-05-08
- Data Source
  KAKENHI-PROJECT-20710147
[Presentation] Impact of definitive haplotypes on genetical analysis2008
- Author(s)
  日笠幸一郎
- Organizer
  58th Annual Meeting of the American Society of Human Genetics
- Place of Presentation
  Pennsylvania, USA
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-20710147
[Presentation] Impact of definitive haplotypes on genetical analysis2008
- Author(s)
  Higasa K, et.al.
- Organizer
  58th Annual Meeting of the American Society of Human Genetic
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2008-11-12
- Data Source
  KAKENHI-PROJECT-17019051
[Presentation] Impact of definitive haplotypes on genetical analysis.2008
- Author(s)
  Higasa K, Kukita Y, Tahira T, Hayashi K
- Organizer
  58th Annual Meeting of the American Society of Human Genetics
- Place of Presentation
  Pennsylvania, USA
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-20710147
[Presentation] Impact of definitive haplotypes for detecting recent positive selection2008
- Author(s)
  Higasa K, et.al.
- Organizer
  2008 Cold Spring Harbor Laboratory Meeting on The Biology of Genomes
- Place of Presentation
  New York, USA
- Year and Date
  2008-05-07
- Data Source
  KAKENHI-PROJECT-17019051
[Presentation] Enhanced D-HaploDB: definitive haplotyes and extended haplotype information determined by genotyping complete hydatidiform mole samples.2007
- Author(s)
  日笠幸一郎
- Organizer
  The 7th International Workshop on Advanced Genomics
- Place of Presentation
  東京
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-18710163
[Presentation] Enhanced D-HaploDB: definitive haplotyes and extended haplotype information determined by genotyping complete hydatidiform mole samples.2007
- Author(s)
  日笠幸一郎
- Organizer
  The American Society of Human Genetics 57th annual meeting
- Place of Presentation
  San Diego, California, America
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18710163
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Higasa Koichiro 日笠 幸一郎

HIGASA Koichiro 日笠 幸一郎

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ヒトゲノム未開拓領域探索法の確立Principal Investigator

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超精密個別化ゲノム解析法の開発による遺伝性疾患の病因病態解明Principal Investigator

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Development and Application of Omics Data Integrated Association Analysis Method Using Multi-Hierarchical Tensor FactorizationPrincipal Investigator

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Construction of high-dimensional Japanese genome reference sequences suitable for the search for disease-associated mutationsPrincipal Investigator

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Detection of Japanese Structural Variation Using Definitive Haplotype Data Obtained from Complete Hydatidiform Moles.Principal Investigator

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決定的ハプロタイプに基づく日本人ヒトゲノム中の自然選択領域の検出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Higasa Koichiro 日笠幸一郎

HIGASA Koichiro 日笠幸一郎