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HOSEN Naoki  保仙 直毅

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Researcher Number 10456923
Other IDs
Affiliation *help 2016 – 2018 : 大阪大学, 医学系研究科, 寄附講座准教授
2016 : 大阪大学, 大学院医学系研究科, 准教授
2011 – 2015 : 大阪大学, 医学(系)研究科(研究院), 准教授
2015 : 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授
2015 : 大阪大学, 大学院医学系研究科・寄附講座, 准教授 … More
2011 : 大阪大学, 医学系・研究科, 准助教
2009 – 2011 : Osaka University, 医学系研究科, 准教授
2009 – 2010 : 大阪大学, 大学院・医学系研究科, 准教授 Less
Review Section/Research Field
Principal Investigator
Hematology / Medium-sized Section 50:Oncology and related fields / Biological Sciences
Except Principal Investigator
Cerebral neurosurgery / Neurosurgery / Cardiovascular medicine / Physical pharmacy / Biological Sciences
Keywords
Principal Investigator
多発性骨髄腫 / 抗体療法 / がん幹細胞 / 白血病 / l抗体療法 / 免疫療法 / 免疫監視 / 多発性骨髄巣 / 白血病幹細胞 / CAR T細胞 … More / 抗体医療 / 腫瘍幹細胞 / 癌幹細胞 / 抗体医薬 / 腫瘍免疫 / モノクローナル抗体 / 癌 / CAR T細胞 / CD8T細胞 / インテグリン / がん … More
Except Principal Investigator
腫瘍幹細胞 / WT1 / ALCAM / 免疫療法 / 腫瘍発生 / 免役療法 / 免疫学 / 分子標的療法 / 神経膠腫 / IL-6 / 沈降速度法 / 生体分子 / 肺動脈性肺高血圧症 / 分子標的治療 / 分子標的薬剤 / サイトカイン / 肺高血圧症 / シグナル伝達 / IL-21 / 立体構造 / interleukin-6 / 治療耐性 / 主要幹細胞 / 脳腫瘍幹細胞 / interleukin-21 / 抗体医薬 / 悪性神経膠腫 / 遺伝子 / 癌 / 免疫逃避 / トランスジェニックマウス / 免疫原性 / 腫瘍免疫 / 高安動脈炎 / 腫瘍内免疫 / 分子診断 / 薬学 / 白血病 / 分子標的治療法 / バイオテクノロジー / 超遠心分析 / 質量分析 / 炎症 / 悪性脳腫瘍 / TNF / 免疫複合体 / 抗体 / 蛋白質 Less
  • Research Projects

    (12results)
  • Research Products

    (64results)
  • Co-Researchers

    (30People)
  •  がん特異的タンパク立体構造を標的としたCAR-T細胞療法の開発Principal InvestigatorOngoing

    • Principal Investigator
      保仙 直毅
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Osaka University
  •  抗体凝集体による免疫原性関連シグナル誘導の物理化学解析と数理モデル構築Ongoing

    • Principal Investigator
      内山 進
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University
  •  恒常的インテグリンβ7活性化シグナルを標的とした骨髄腫幹細胞排除法の開発Principal InvestigatorOngoing

    • Principal Investigator
      保仙 直毅
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Osaka University
  •  WT1ペプチドワクチンを中心とした悪性神経膠腫幹細胞標的療法の探索Ongoing

    • Principal Investigator
      香川 尚己
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Osaka University
  •  Molecular mechanism of Vasculitis and Pulmonary arterial hypertension via inflammatory cytokines

    • Principal Investigator
      Nakaoka Yoshikazu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of antibody therapy targeting multiple myeloma-specific glyco-epitopePrincipal Investigator

    • Principal Investigator
      Hosen Naoki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Osaka University
  •  Influence of Glioblastoma stem cells to the escape phenomenon in immunotherapy including WT1 vaccination

    • Principal Investigator
      KAGAWA Naoki
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Osaka University
  •  白血病幹細胞の腫瘍免疫監視からの逸脱機序の解明およびその制御Principal Investigator

    • Principal Investigator
      保仙 直毅
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Identification of multiple myeloma stem cells and development of antibody therapy targeting themPrincipal Investigator

    • Principal Investigator
      HOSEN Naoki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Osaka University
  •  Identification of novel brain tumor stem cell markers and development of molecular targeting therapies for malignant gliomas

    • Principal Investigator
      KAGAWA Naoki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Osaka University
  •  Identification of multiple myeloma stem cells and establishment of antibody therapy against themPrincipal Investigator

    • Principal Investigator
      HOSEN Naoki
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Osaka University
  •  Development of molecular diagnosis and molecule-targeted therapy for leukemia

    • Principal Investigator
      SUGIYAMA Haruo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 Other

All Journal Article Presentation Book

  • [Book] 骨髄腫幹細胞 多発性骨髄腫治療マニュアル2012

    • Author(s)
      保仙 直毅
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Book] 多発性骨髄腫幹細胞攻略のストラテジー実験医学増刊がん幹細胞2011

    • Author(s)
      保仙直毅
    • Publisher
      羊土社, (東京)
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Book] 骨髄腫幹細胞多発性骨髄腫治療マニュアル2011

    • Author(s)
      保仙直毅
    • Publisher
      南江堂, (東京)
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Book] 造血器腫瘍におけるがん幹細胞を標的とした抗体医薬の開発がん基盤生物学

    • Author(s)
      保仙直毅
    • Publisher
      南山堂, (東京)
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide2016

    • Author(s)
      Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Elisseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
    • Journal Title

      Int J Cancer

      Volume : 139 Pages : 1391-401

    • DOI
      10.1002/ijc.30182
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462257, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K08609, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K09476, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-15K19550
  • [Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide2016

    • Author(s)
      Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Eliseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H
    • Journal Title

      Int J Cancer

      Volume : -

    • Open Access / Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592160
  • [Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016

    • Author(s)
      Oji Y, Naoya Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Eliseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
    • Journal Title

      Int J Cancer.

      Volume : -

    • Open Access / Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10331
  • [Journal Article] Glycosylation status of CD43 protein is associated with resistance of leukemia cells to CTL-mediated cytolysis2016

    • Author(s)
      Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, Okumura A, Fujioka Y, Urakawa R, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Miyoshi E, Hirata T, Kumanogoh A, Sugiyama H, Hosen N.
    • Journal Title

      PLoS ONE

      Volume : 11

    • DOI
      10.1371/journal.pone.0152326
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460588, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-26461404
  • [Journal Article] Wilms tumor 1-peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015

    • Author(s)
      Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
    • Journal Title

      Cancer Immunol Immunother.

      Volume : - Pages : 707-16

    • DOI
      10.1007/s00262-015-1674-8
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25830116, KAKENHI-PROJECT-26462180, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-24592160, KAKENHI-PROJECT-25462256
  • [Journal Article] Interleukin-6/Interleukin-21-signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.2015

    • Author(s)
      Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M, Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K, Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, and Nakaoka Y
    • Journal Title

      Proc Natl Acad Sci USA

      Volume : Early Edition Pages : 1-10

    • DOI
      10.1073/pnas.1424774112
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-15K01712, KAKENHI-PROJECT-15K15309, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25293183
  • [Journal Article] lms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis.2014

    • Author(s)
      Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T.
    • Journal Title

      Anticancer Res.

      Volume : 34(1) Pages : 61-7

    • Data Source
      KAKENHI-PROJECT-24592160
  • [Journal Article] 1.Wilms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis.2014

    • Author(s)
      Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T
    • Journal Title

      Anticancer Res.

      Volume : 34 Pages : 61-67

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592160
  • [Journal Article] The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression2014

    • Author(s)
      Wagner KD, Cherfils-Vicini J, Hosen N, Hohenstein P, Gilson E, Hastie ND, Michiels JF, Wagner N.
    • Journal Title

      Nat Commun

      Volume : 5 Pages : 5852-5852

    • DOI
      10.1038/ncomms6852
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461404
  • [Journal Article] Multiple myeloma-initiating cells2013

    • Author(s)
      Hosen N
    • Journal Title

      Int J Hematol

      Volume : 97(3) Pages : 306-312

    • Data Source
      KAKENHI-PROJECT-23591386
  • [Journal Article] Identification of myeloma-initiating cells and development of their targeting therapy2013

    • Author(s)
      Hosen N , Sugiyama H
    • Journal Title

      Rinsho Ketsueki

      Volume : 54(6) Pages : 505-512

    • Data Source
      KAKENHI-PROJECT-23591386
  • [Journal Article] Identification of myeloma-initiating cells and development of their targeting therapy2013

    • Author(s)
      Hosen, N., and H. Sugiyama.
    • Journal Title

      Rinsho Ketsueki

      Volume : 54 Pages : 505-512

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Journal Article] Cd138-negative clonogenic cells are plasma cells but not b cells in some multiple myeloma patients2012

    • Author(s)
      Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, Mugitani A, Ichihara H, Aoyama Y, Nishida S, Tsuboi A, Fujiki F, Tatsumi N, Nakajima H, Hino M, Kimura T, Yata K, Abe M, Oka Y, Oji Y, Kumanogoh A, Sugiyama H.
    • Journal Title

      Leukemia

      Volume : (in press) Pages : 2135-2141

    • DOI
      10.1038/leu.2012.80
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591205, KAKENHI-PUBLICLY-23130509, KAKENHI-PROJECT-23591386, KAKENHI-PROJECT-23591390, KAKENHI-PROJECT-23790622
  • [Journal Article] Long-term wt1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease2012

    • Author(s)
      1Tsuboi A, Oka Y, Kyo T, Katayama Y, Elisseeva OA, Kawakami M, Nishida S, Morimoto S, Murao A, Nakajima H, Hosen N, Oji Y, Sugiyama H
    • Journal Title

      Leukemia

      Volume : 26 Pages : 1410-1413

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23130509
  • [Journal Article] CD 138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients2012

    • Author(s)
      Hosen N, Matsuoka Y, Kishida S, et al
    • Journal Title

      Leukemia

      Volume : 26(9) Pages : 2135-2141

    • Data Source
      KAKENHI-PROJECT-23591386
  • [Journal Article] CD 48 as a novel molecular target for antibody therapy in multiple myeloma2012

    • Author(s)
      Hosen N, Ichihara H, Mugitani A, et al
    • Journal Title

      Br J Haematol

      Volume : 156(2) Pages : 213-224

    • Data Source
      KAKENHI-PROJECT-23591386
  • [Journal Article] Enhanced tumor immunity of WT1 peptide vaccination by interferon-βadministration2012

    • Author(s)
      Nakajima H, Hosen N(4番目), et al(16名)
    • Journal Title

      Vaccine

      Volume : 30(4) Pages : 722-729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] WT1 Peptide Therapy for a Patient with Chemotherapy-resistant Salivary Gland Cancer2012

    • Author(s)
      Shirakata T, Hosen N(4番目), et al(11名)
    • Journal Title

      Anticancer Res

      Volume : 32(3) Pages : 1081-1085

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] Activated leukocyte cell adhesion molecule (ALCAM) is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion2012

    • Author(s)
      Noriyuki Kijima
    • Journal Title

      Neuro Oncol

      Volume : (in Press) Pages : 1254-1264

    • DOI
      10.1093/neuonc/nor202
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791343, KAKENHI-PUBLICLY-23130509, KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-24592160, KAKENHI-PROJECT-24791499, KAKENHI-PROJECT-21591870, KAKENHI-PUBLICLY-22103508, KAKENHI-PROJECT-22659259, KAKENHI-PROJECT-23791595
  • [Journal Article] Biased usage of T cell receptorβ-chain variable region genes of Wilms' tumor gene(WT1)-specific CD8+ T cells in patients with solid tumors and healthy donors2012

    • Author(s)
      Morimoto S., et al
    • Journal Title

      Cancer Sci

      Volume : 103 Pages : 408-414

    • DOI
      10.1111/j.1349-7006.2011.02163.x
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590991, KAKENHI-PROJECT-21591205, KAKENHI-PROJECT-22700896, KAKENHI-PROJECT-23390364, KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-23592148, KAKENHI-PROJECT-24592160, KAKENHI-PROJECT-21591870, KAKENHI-PUBLICLY-22103508
  • [Journal Article] CD48 as a novel molecular target for antibody therapy in multiple myeloma2012

    • Author(s)
      Hosen N(1番目), et al(20名)
    • Journal Title

      Leukemia

      Volume : 156(2) Pages : 213-224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] CD48 as a novel molecular target for antibody therapy in multiple myeloma.2011

    • Author(s)
      Hosen N, Ichihara H, Mugitani A, Aoyama Y, Fukuda Y, Kishida S, Matsuoka Y,Nakajima H, et al
    • Journal Title

      British Journal of Haematology

      Volume : 156 Pages : 213-224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Journal Article] WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse : successful maintenance of durable remission2011

    • Author(s)
      Hashii Y, Hosen N(7番目), et al(12名)
    • Journal Title

      Leukemia

      Volume : 26(3) Pages : 530-532

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] Biased usage of T cell receptorβ-chain variable region genes of Wilms' tumor gene(WT1)-specific CD8(+) T cells in patients with solid tumors and healthy donors2011

    • Author(s)
      Morimoto S, Hosen N(7番目), Kagawa N(16番目), Hashimoto N(17番目), Yoshimine T(18番目), et al(21名)
    • Journal Title

      Cancer Science

      Volume : (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] CD166/ Activated leukocyte cell adhesion, molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion2011

    • Author(s)
      Kijima N, Hosen N(2番目), Kagawa N(3番目), Hashimoto N(4番目), Yoshimine T(9番目), et al:
    • Journal Title

      Neuro-Oncology

      Volume : (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] Long-term WT1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease2011

    • Author(s)
      Tuboi A、Hosen N(11番目), et al(13名)
    • Journal Title

      Leukemia

      Volume : (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] Use of(11) C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2011

    • Author(s)
      Chiba Y, Kinoshita M(2番目), Kagawa N(6番目), Hashimoto N(2番目), Hosen N(14番目), Yoshimine T(15番目), et al(15名)
    • Journal Title

      Journal of Neurosurgery

      Volume : (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] Biased usage of BV gene families of T cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies2010

    • Author(s)
      Tanaka-Harada Y, Kawakami M, Oka Y, Tsuboi A, Katagiri T, Elisseeva O, Nishida S, Shirakata T, Hosen N, Fujiki F, Murao A, Nakajima H, Oji Y, Kanda Y, Kawase I, Sugiyama H.
    • Journal Title

      Cancer Science 101

      Pages : 594-600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma2010

    • Author(s)
      Chiba Y, Hashimoto N(2番目), Kinoshita M(6番目), Kagawa N(7番目), Hosen N(9番目), Yoshimine T(12番目), et al(12名)
    • Journal Title

      JPN J Clin Oncol

      Volume : 40(5) Pages : 395-408

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591870
  • [Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow (BM) in tumor-bearing patients: an important role of BM as a secondary lymphoid organ.2010

    • Author(s)
      Murao A, Oka Y, Tsuboi A, Elisseeva OA, Harada Y, Fujiki F, Nakajima H, Nishida S, Hosen N, Shirakata T, Hashimoto N, Myoui A, Ueda T, Takeda Y, Osaki T, Enomoto T, Yoshikawa H, Kimura T, Oji Y, Kawase I, Sugiyama H.
    • Journal Title

      Cancer Science (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Journal Article] Identification of a WT1 protein-derived peptide, WT1187 as an HLA-A*0206-restricted, WT1-specific CTL epitope" is currently at the following stage of production.2008

    • Author(s)
      Li Z, Oka Y, Tsuboi A, Fujiki F, Harada Y, Nakajima H, Masuda T, Fukuda Y, Kawakatsu M, Morimoto S, Katagiri T, Tatsumi N, Hosen N, Shirakata T, Nishida S, Kawakami Y, Udaka K, Kawase I, Oji Y, Sugiyama H.
    • Journal Title

      Microbiol Immunol 52

      Pages : 551-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Journal Article] Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies.2005

    • Author(s)
      Wu F, Oka Y, Tsuboi A, Elisseeva O. A, Nakajima H, Fujiki F, Masuda T, Murakami M, Yoshihara S, Ikegame K, Hosen N, Kawakami M, Nakagawa M, Kubota T, Soma T, Yamagami T, Tsukaguchi M, Ogawa H, Oji Y, Hamaoka T, Kawase I, Sugiyama H.
    • Journal Title

      Leukemia 19

      Pages : 268-274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Presentation] Identification of multiple myeloma-specific antigens as immunotherapeutic targets2016

    • Author(s)
      Naoki Hosen1), Kana Hasegawa1), Yasutaka Aoyama5, Ichihara, Atsuko Mugitani, Takafumi Nakao6, Yamane, Manabe7, Akihiro Tsuboi2), Jun Nakata2), Sumiyuki Nishida3), Yoshihiro Oka4),Yusuke Oji1), Masayuki Hino8, Atsushi Kumanogoh3), Haruo Sugiyama4)
    • Organizer
      日本血液学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-10-14
    • Data Source
      KAKENHI-PROJECT-26461404
  • [Presentation] RESPONSEASSESSMENTS IN WT1 PEPTIDE VACCINATION AND LONG TERM RESULTS OF COMOZOLOMIDE THERAPY2014

    • Author(s)
      Naoya Hashimoto,Akihiro Tsuboi,Yasuyoshi Chiba,Yoshihiro Oka,Soyoko Morimoto,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Naoki Kagawa,Yusuke Oji,Toshiki Yoshimine,Haruo Sugiyama
    • Organizer
      The7th International Conference on WT1 in human neoplasia
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-04-23
    • Data Source
      KAKENHI-PROJECT-24592160
  • [Presentation] CD48 as a novel molecular target for antibody therapy in multiple myeloma2013

    • Author(s)
      保仙直毅
    • Organizer
      Keystone Symposium
    • Year and Date
      2013-01-30
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Presentation] Expression of activated leukocyte cell adhesion molecule (ALCAM) influences prognosis in malignant glioma2012

    • Author(s)
      Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, Yasunori Fujimoto, and Toshiki Yoshimine
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24592160
  • [Presentation] Retrospective analysis of relation between clinical outcome and molecular classification of medulloblastomas2012

    • Author(s)
      Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, and Toshiki Yoshimine
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24592160
  • [Presentation] Relationship between activated leukocyte cell adhesion molecule and prognosis in malignant glioma2012

    • Author(s)
      Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, Yasunori Fujimoto, and Toshiki Yoshimine
    • Organizer
      第30回日本脳腫瘍病理学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-24592160
  • [Presentation] Analysis of escape mechanism from tumor immunity in leukemia-initiating cells using mouse leukemia models induced by MLL-ENL oncogenes2012

    • Author(s)
      保仙直毅
    • Organizer
      幹細胞シンポジウム
    • Year and Date
      2012-05-31
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Presentation] Origin of the myeloma initiating cells and development of its targeting therapies2012

    • Author(s)
      Naoki Hosen
    • Organizer
      第74回日本血液学会総会
    • Place of Presentation
      国立京都国際会館
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Presentation] Origin of the myeloma initiating cells and development of its targeting therapies2012

    • Author(s)
      保仙直毅
    • Organizer
      日本血液学会総会
    • Year and Date
      2012-10-21
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Presentation] Clonogenic Multiple Myeloma Cells2012

    • Author(s)
      保仙直毅
    • Organizer
      日本血液学会国際シンポジウム
    • Year and Date
      2012-05-26
    • Data Source
      KAKENHI-PROJECT-23591386
  • [Presentation] Analysis of immune escape in leukemia-initiating cells using mouse leukemia models induced by MLL-fusion oncogene2012

    • Author(s)
      保仙 直毅
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      ウェスティンホテル淡路、兵庫
    • Year and Date
      2012-05-31
    • Data Source
      KAKENHI-PUBLICLY-23130509
  • [Presentation] Clonogenic myeloma progenitor exists in CD19-CD38^<++> plasma cells2010

    • Author(s)
      保仙直毅、岸田諭、松岡由和、市原弘善、青山泰孝、麥谷安津子、川上学、山上保、村上雅樹、玉置広哉、中尾隆文、藤重夫、中島博子、日野雅之、岡芳弘、杉山治夫
    • Organizer
      日本血液学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] MMSC-1 as a novel molecular target for antibody therapy in multiple myeloma2010

    • Author(s)
      保仙直毅、津子、川上学、山上保、村上雅樹、玉置広哉、中尾隆文、藤重夫、中島博子、日野雅之、岡芳弘、杉山治夫
    • Organizer
      日本血液学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-26
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] Clonogenic myeloma progenitor exists in CD19-CD38^<++> plasma cells2010

    • Author(s)
      保仙直毅、杉山治夫
    • Organizer
      米国血液学会
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2010-12-04
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] Identification and targeting of multiple myeloma progenitor cells2010

    • Author(s)
      保仙直毅、岸田諭、中田潤、松岡由和、杉山治夫
    • Organizer
      幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Year and Date
      2010-05-13
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] 腫瘍幹細胞:B細胞系悪性腫瘍からの考察2010

    • Author(s)
      保仙直毅
    • Organizer
      第69回日本癌学会総会ランチョンセミナー
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] Multiple myeloma progenitor cells exist in CD19^-CD38^<++> plasma cell population2010

    • Author(s)
      保仙直毅
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] Multiple myeloma progenitor cells exist in CD19^-CD38^<++> plasma cell population2010

    • Author(s)
      保仙直毅
    • Organizer
      第52回米国血液学会
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2010-12-05
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] 腫瘍幹細胞:B細胞性腫瘍幹細胞からの考察(ランチョンセミナー)2010

    • Author(s)
      保仙直毅
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] MMSC-1 is a novel target molecule for antibody therapy against both multiple myeloma progenitor cells and mature myeloma plasma cells2009

    • Author(s)
      保仙直毅
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      スイス
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] MDSに対するWT1ワクチン療法2009

    • Author(s)
      坪井昭博、岡芳弘、川上学、尾路祐介、保仙直毅、西田純幸、米谷昇、杉山治夫
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Presentation] 多発性骨髄腫に対する抗体療法のための新規標的抗原2009

    • Author(s)
      保仙直毅、水谷陽介、小林丈二、岸田諭、岡芳弘、川瀬一郎、杉山治夫
    • Organizer
      日本造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-08-28
    • Data Source
      KAKENHI-PROJECT-21790917
  • [Presentation] グリベックとの併用によるCMLに対するWT1ペプチドワクチン免疫療法2009

    • Author(s)
      尾路祐介、岡芳弘、西田純幸、白方俊章、保仙直毅、坪井昭博、中島博子、村尾綾子、杉山治夫
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Presentation] MDS-AMLに対しHLA-A*2402拘束性改変型WT1ペプチドワクチン療法を行い、長期間AMLの再発なく経過している1例2008

    • Author(s)
      西田純幸、川上学、坪井昭博、村尾綾子、宮井沙緒里、白方俊章、保仙直毅、尾路祐介、塚口真知子、岡芳弘、杉山治夫
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-11
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Presentation] グリベックとの併用によるCMLに対するWT1ペプチドワクチン免疫療法2008

    • Author(s)
      尾路祐介、白方俊章、岡芳弘、西田純幸、坪井昭博、保仙直毅、杉山治夫
    • Organizer
      第89回近畿血液学地方会
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-21
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Presentation] グリベックとの併用によるCMLに対するWT1ペプチドワクチン免疫療法2008

    • Author(s)
      尾路祐介、岡芳弘、西田純幸、白方俊章、保仙直毅、高橋和子、村尾綾子、中島博子、坪井昭博、杉山治夫
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Presentation] WT1 peptide vaccination at very low-dose for myelodysplastic syndrome.2007

    • Author(s)
      Kawakami M, Oka Y, Tsuboi A, Harada Y, Elisseeva OA, Furukawa Y, Hayashi T, Nishida S, Shirakata T; Hosen N, Nakajima H, Yamagami T, Soma T, Oji Y, Sugiyama H.
    • Organizer
      3rd International Conference on WT1 in Human Malignancies
    • Place of Presentation
      Berlin
    • Year and Date
      2007-09-19
    • Data Source
      KAKENHI-PROJECT-17015028
  • [Presentation] 神経膠芽腫におけるCD166発現とsubventricular zoneとの関係-再発形式と予後への影響

    • Author(s)
      香川尚己、木嶋教行、保仙直毅、平山龍一、千葉泰良、高野浩司、木下学、中西克彦、永野大輔、福屋章悟、藤本康倫、橋本直哉、吉峰俊樹
    • Organizer
      日本脳腫瘍学会学術集会
    • Place of Presentation
      フェニックスシーガイアリゾート(宮崎)
    • Data Source
      KAKENHI-PROJECT-24592160
  • 1.  KAGAWA Naoki (50444542)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 17results
  • 2.  HASHIMOTO Naoya (90315945)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 16results
  • 3.  SUGIYAMA Haruo (70162906)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 10results
  • 4.  OKA Yoshihiro (20273691)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 11results
  • 5.  OJI Yusuke (20294100)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 13results
  • 6.  FUJIKI Fumihiro (40456926)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 7results
  • 7.  YOSHIMINE Toshiki (00201046)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 4results
  • 8.  KINOSHITA Manabu (40448064)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 4results
  • 9.  Nakaoka Yoshikazu (90393214)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 10.  SHIRAI MIKIYASU (70162758)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 11.  内山 進 (90335381)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 12.  大戸 梅治 (90451856)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 13.  TATSUMI Naoya
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 14.  Chiba Yasuyoshi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 15.  Hirata Takako
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 16.  INAGAKI TADAKATSU
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 17.  KOMURO ISSEI
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 18.  安倍 正博
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 19.  坪井 昭博
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 20.  泉本 修一
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 21.  藤田 貢
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 22.  加藤 天美
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 23.  奥田 武司
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 24.  一迫 玲
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 25.  西田 純幸
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 26.  中田 潤
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 27.  森本 創世子
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 28.  木嶋 教行
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 29.  森 鑑二
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 30.  瀧原 圭子
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results

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