hosen naoki 保仙直毅

… Alternative Names

HOSEN Naoki 保仙直毅

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Researcher Number	10456923
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 大阪大学, 大学院医学系研究科, 教授 2019 – 2021: 大阪大学, 医学系研究科, 教授 2016 – 2018: 大阪大学, 医学系研究科, 寄附講座准教授 2016: 大阪大学, 大学院医学系研究科, 准教授 2015: 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 … More 2015: 大阪大学, 大学院医学系研究科・寄附講座, 准教授 2011 – 2015: 大阪大学, 医学(系)研究科(研究院), 准教授 2011: 大阪大学, 医学系・研究科, 准助教 2009 – 2011: Osaka University, 医学系研究科, 准教授 2009 – 2010: 大阪大学, 大学院・医学系研究科, 准教授 Less
Review Section/Research Field	Principal Investigator Hematology / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54010:Hematology and medical oncology-related / Biological Sciences / Transformative Research Areas, Section (III) / Medium-sized Section 50:Oncology and related fields Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 54010:Hematology and medical oncology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56010:Neurosurgery-related … More / Cerebral neurosurgery / Physical pharmacy / Cardiovascular medicine / Neurosurgery / Biological Sciences Less
Keywords	Principal Investigator 多発性骨髄腫 / NK細胞 / CAR T細胞 / 抗体療法 / CAR NK細胞 / CAR-NK細胞 / CAR T細胞療法 / がん幹細胞 / がん免疫療法 / 遺伝子細胞治療 … More / 細胞医薬 / ＣAR－Ｔ細胞 / CAR-T細胞 / ネオセルフ / CAR T 細胞療法 / ＣＡＲ－Ｔ細胞 / 免疫療法 / がん / 癌 / インテグリン / CAR　T細胞 / 多発性骨髄巣 / 抗体医療 / l抗体療法 / モノクローナル抗体 / 免疫監視 / CD8T細胞 / 腫瘍免疫 / 白血病幹細胞 / 白血病 / 抗体医薬 / 癌幹細胞 / 腫瘍幹細胞 … More Except Principal Investigator 腫瘍幹細胞 / WT1 / 肺癌 / キメラ抗原受容体T細胞療法 / 腫瘍微小環境 / CAR-T / 膠芽腫 / ALCAM / 分子標的治療 / 免疫療法 / 白血病 / 腫瘍間質 / 胸腺上皮性腫瘍 / 寒冷凝集素 / 補体関連疾患 / 自己免疫性溶血性貧血 / CAD / 血管外溶血 / 抗補体薬 / 古典経路 / 補体 / 寒冷凝集素症 / 多発性骨髄腫 / プロバイオティクス / 免疫細胞療法 / 血液悪性疾患 / 造血細胞移植 / 腸内細菌叢 / 胸膜播種 / 癌関連線維芽細胞 / Dimshift / デジタルPCR / キメリズム / CART細胞療法 / CAR-T細胞療法 / 系統樹 / 遺伝学的系統樹解析 / 全ゲノム解析 / 血液疾患 / PNH / 発作性夜間ヘモグロビン尿症 / バイオテクノロジー / シグナル伝達 / 薬学 / 生体分子 / 沈降速度法 / 超遠心分析 / TNF / 免疫複合体 / 抗体 / 立体構造 / 質量分析 / 凝集体 / 蛋白質 / バイオ医薬品 / 分析 / 免疫原性 / 界面 / タンパク質 / 凝集 / 安定性 / 抗体医薬 / バイオ医薬 / トランスジェニックマウス / 肺高血圧症 / IL-21 / IL-6 / interleukin-21 / interleukin-6 / 高安動脈炎 / 肺動脈性肺高血圧症 / サイトカイン / 炎症 / 腫瘍免疫 / 免疫逃避 / 腫瘍血管正常化 / 免疫逃避現象 / 悪性神経膠腫 / 神経膠腫 / 脳腫瘍幹細胞 / 腫瘍内免疫 / 主要幹細胞 / 治療耐性 / 腫瘍発生 / 分子標的薬剤 / 悪性脳腫瘍 / 免疫学 / 癌 / 遺伝子 / 免役療法 / 分子標的治療法 / 分子標的療法 / 分子診断 Less

早期肺癌組織内の線維芽細胞による細胞外基質改変の機序解明と悪性度診断法の探索
- Principal Investigator
  
  木村亨
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  The University of Osaka
膠芽腫に対するCAR-T、CAR-NK細胞療法の標的抗原の最適化と腫瘍微小環境の解析
- Principal Investigator
  
  木嶋教行
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  The University of Osaka
腫瘍微小環境をmodifyするデザイナー免疫細胞の開発Principal Investigator
- Principal Investigator
  
  保仙直毅
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Osaka
血液がん患者体内で増殖し長期間生存するCAR-T細胞の単離とその制御分子の同定Principal Investigator
- Principal Investigator
  
  保仙直毅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Osaka University
デジタルPCRを用いた造血幹細胞移植後新規キメリズム解析法の開発
- Principal Investigator
  
  上田智朗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
胸膜播種モデルマウスに対するFAP CAR-T細胞を用いた新規治療法の検討
- Principal Investigator
  
  杉浦裕典
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Osaka University
自己糖鎖認識機構の制御によりがん認識能を増強したCAR-NK細胞の開発Principal Investigator
- Principal Investigator
  
  保仙直毅
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Osaka University
免疫監視能強化CAR-NK細胞を用いたがんの再発予防法の開発Principal Investigator
- Principal Investigator
  
  保仙直毅
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Osaka University
造血細胞移植の予後および合併症リスクを規定する腸内細菌叢関連因子の探索
- Principal Investigator
  
  福島健太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
多発性骨髄腫の炎症性微小環境におけるSTAP蛋白の役割
- Principal Investigator
  
  一井倫子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Osaka University
Unraveling the mechanism of poor response to anti-comlement drug in cold agglutinin disease treatment
- Principal Investigator
  
  植田康敬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Osaka University
胸腺上皮性腫瘍の腫瘍間質をターゲットとした治療戦略の探索
- Principal Investigator
  
  寛島隆史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Osaka University
PNHクローンの起源と変遷
- Principal Investigator
  
  高森弘之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Identification of glioblastoma-specific antigens for chimeric antigen receptor T cell therapy
- Principal Investigator
  
  木嶋教行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka University
Development of a new CAR-NK cell derived from cord bloodPrincipal Investigator
- Principal Investigator
  
  Hosen Naoki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Osaka University
Characterization of novel acute myeloid leukemia-specific cell surface antigen identified as targets for CAR T cell therapyPrincipal Investigator
- Principal Investigator
  
  Hosen Naoki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Osaka University
CAR T cell therapy targeting neo-self antigensPrincipal Investigator
- Principal Investigator
  
  保仙直毅
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Development of CAR-T cell therapy targeting cancer-specific protein conformationsPrincipal Investigator
- Principal Investigator
  
  Hosen Naoki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Osaka University
Physico-chemical and mathematical analyses of immune related signal induced by antibody aggregates
- Principal Investigator
  
  Uchiyama Susumu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
Development of methods for elimination of multiple myeloma stem cells targeting constitutively activated integrin beta 7Principal Investigator
- Principal Investigator
  
  Hosen Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Translational research for cancer immunotherapy targeting glioblastoma initiating cells based on WT1 vaccination
- Principal Investigator
  
  Kagawa Naoki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka University
Molecular mechanism of Vasculitis and Pulmonary arterial hypertension via inflammatory cytokines
- Principal Investigator
  
  Nakaoka Yoshikazu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of antibody therapy targeting multiple myeloma-specific glyco-epitopePrincipal Investigator
- Principal Investigator
  
  Hosen Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Influence of Glioblastoma stem cells to the escape phenomenon in immunotherapy including WT1 vaccination
- Principal Investigator
  
  KAGAWA Naoki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka University
白血病幹細胞の腫瘍免疫監視からの逸脱機序の解明およびその制御Principal Investigator
- Principal Investigator
  
  保仙直毅
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Identification of multiple myeloma stem cells and development of antibody therapy targeting themPrincipal Investigator
- Principal Investigator
  
  HOSEN Naoki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Identification of novel brain tumor stem cell markers and development of molecular targeting therapies for malignant gliomas
- Principal Investigator
  
  KAGAWA Naoki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka University
Identification of multiple myeloma stem cells and establishment of antibody therapy against themPrincipal Investigator
- Principal Investigator
  
  HOSEN Naoki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Development of molecular diagnosis and molecule-targeted therapy for leukemia
- Principal Investigator
  
  SUGIYAMA Haruo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

[Book] 骨髄腫幹細胞　多発性骨髄腫治療マニュアル2012
- Author(s)
  保仙　直毅
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591386
[Book] 多発性骨髄腫幹細胞攻略のストラテジー実験医学増刊がん幹細胞2011
- Author(s)
  保仙直毅
- Publisher
  羊土社, (東京)
- Data Source
  KAKENHI-PROJECT-23591386
[Book] 骨髄腫幹細胞多発性骨髄腫治療マニュアル2011
- Author(s)
  保仙直毅
- Publisher
  南江堂, (東京)
- Data Source
  KAKENHI-PROJECT-23591386
[Book] 造血器腫瘍におけるがん幹細胞を標的とした抗体医薬の開発がん基盤生物学
- Author(s)
  保仙直毅
- Publisher
  南山堂, (東京)
- Data Source
  KAKENHI-PROJECT-23591386
[Journal Article] Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation2024
- Author(s)
  Fukushima Kentaro、Kudo Hayami、Oka Kentaro、Hayashi Atsushi、Onizuka Makoto、Kusakabe Shinsuke、Hino Akihisa、Takahashi Motomichi、Takeda Kiyoshi、Mori Masaki、Ando Kiyoshi、Hosen Naoki
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 59 Issue: 6 Pages: 795-802
- DOI
  10.1038/s41409-024-02250-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06695
[Journal Article] Identification of glioblastoma-specific antigens expressed in patient-derived tumor cells as candidate targets for chimeric antigen receptor T cell therapy2022
- Author(s)
  Nakagawa T, Kijima N, Hasegawa K, Ikeda S, Yaga M, Wibowo T, Tachi T, Kuroda H, Hirayama R, Okita Y, Kinoshita M, Kagawa N, Kanemura Y, Hosen N, Kishima H.
- Journal Title
  
  Neurooncol Adv.
  
  Volume: 5(1) Issue: 1
- DOI
  10.1093/noajnl/vdac177
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09457, KAKENHI-PROJECT-19K09526, KAKENHI-PROJECT-22K09200, KAKENHI-PROJECT-22K09283, KAKENHI-PROJECT-20H03710, KAKENHI-PROJECT-22K09231
[Journal Article] Autonomous TGFbeta signaling induces phenotypic variation in human acute myeloid leukemia.2021
- Author(s)
  1.Shingai, Y., T. Yokota, D. Okuzaki, T. Sudo, T. Ishibashi, Y. Doi, T. Ueda, T. Ozawa, R. Nakai, A. Tanimura, M. Ichii, H. Shibayama, Y. Kanakura, and N. Hosen.
- Journal Title
  
  Stem Cells
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H04810
[Journal Article] Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.2020
- Author(s)
  Toda J, Ichii M, Oritani K, Shibayama H, Tanimura A, Saito H, Yokota T, Motooka D, Okuzaki D, Kitai Y, Muromoto R, Kashiwakura JI, Matsuda T, Hosen N, Kanakura Y.
- Journal Title
  
  Oncogene
  
  Volume: 39 Issue: 34 Pages: 5601-5615
- DOI
  10.1038/s41388-020-01387-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-20K08356, KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-20H03710, KAKENHI-PROJECT-18K08355, KAKENHI-PROJECT-19K17829
[Journal Article] Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma2019
- Author(s)
  Hosen Naoki
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 12 Pages: 2024-2024
- DOI
  10.3390/cancers11122024
- NAID
  130007496853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04207
[Journal Article] A phase I clinical study of a cocktail vaccine of Wilms’ tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma2018
- Author(s)
  Tsuboi A, Hashimoto N, Fujiki F, Morimoto S, Kagawa N, Nakajima H, Hosen N, Nishida S, Nakata J, Morita S, Sakamoto J, Oji Y, Oka Y, Sugiyama H
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 68(2) Issue: 2 Pages: 331-340
- DOI
  10.1007/s00262-018-2274-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-17K07215, KAKENHI-PROJECT-17K07216
[Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016
- Author(s)
  Oji Y, Naoya Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Eliseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
- Journal Title
  
  Int J Cancer.
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10331
[Journal Article] Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis.2016
- Author(s)
  Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, Okumura A, Fujioka Y, Urakawa R, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Miyoshi E, Hirata T, Kumanogoh A, Sugiyama H, Hosen N.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e0152326-e0152326
- DOI
  10.1371/journal.pone.0152326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-25460588, KAKENHI-PROJECT-25460685, KAKENHI-PROJECT-26461404
[Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016
- Author(s)
  Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Elisseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
- Journal Title
  
  Int J Cancer.
  
  Volume: 139 Issue: 6 Pages: 1391-401
- DOI
  10.1002/ijc.30182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462257, KAKENHI-PROJECT-26430162, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K18446, KAKENHI-PROJECT-15K08609, KAKENHI-PROJECT-15K09173, KAKENHI-PROJECT-15K09476, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-16K11136, KAKENHI-PROJECT-15K19550
[Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide2016
- Author(s)
  Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Eliseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H
- Journal Title
  
  Int J Cancer
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592160
[Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015
- Author(s)
  Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
- Journal Title
  
  Cancer Immunology Immunotherapy
  
  Volume: - Issue: 6 Pages: 707-16
- DOI
  10.1007/s00262-015-1674-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25830116, KAKENHI-PROJECT-26462180, KAKENHI-PROJECT-26462195, KAKENHI-PROJECT-15K10331, KAKENHI-PROJECT-24592160, KAKENHI-PROJECT-25462256
[Journal Article] Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension2015
- Author(s)
  Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M, Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K, Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, and Nakaoka Y
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: Early Edition Issue: 20 Pages: 1-10
- DOI
  10.1073/pnas.1424774112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-15K01712, KAKENHI-PROJECT-15K15309, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25293183
[Journal Article] lms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis.2014
- Author(s)
  Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T.
- Journal Title
  
  Anticancer Res.
  
  Volume: ３４（１） Pages: 61-7
- Data Source
  KAKENHI-PROJECT-24592160
[Journal Article] The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression2014
- Author(s)
  Wagner KD, Cherfils-Vicini J, Hosen N, Hohenstein P, Gilson E, Hastie ND, Michiels JF, Wagner N.
- Journal Title
  
  Nat Commun
  
  Volume: 5 Issue: 1 Pages: 5852-5852
- DOI
  10.1038/ncomms6852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461404
[Journal Article] 1.Wilms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis.2014
- Author(s)
  Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T
- Journal Title
  
  Anticancer Res.
  
  Volume: 34 Pages: 61-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592160
[Journal Article] Multiple myeloma-initiating cells2013
- Author(s)
  Hosen N
- Journal Title
  
  Int J Hematol
  
  Volume: 97(3) Pages: 306-312
- NAID
  10031162894
- Data Source
  KAKENHI-PROJECT-23591386
[Journal Article] Identification of myeloma-initiating cells and development of their targeting therapy2013
- Author(s)
  Hosen N , Sugiyama H
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 54(6) Pages: 505-512
- NAID
  10031185450
- Data Source
  KAKENHI-PROJECT-23591386
[Journal Article] Identification of myeloma-initiating cells and development of their targeting therapy2013
- Author(s)
  Hosen, N., and H. Sugiyama.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 54 Pages: 505-512
- NAID
  10031185450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591386
[Journal Article] Long-term wt1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease2012
- Author(s)
  1Tsuboi A, Oka Y, Kyo T, Katayama Y, Elisseeva OA, Kawakami M, Nishida S, Morimoto S, Murao A, Nakajima H, Hosen N, Oji Y, Sugiyama H
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 1410-1413
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23130509
[Journal Article] Enhanced tumor immunity of WT1 peptide vaccination by interferon-βadministration2012
- Author(s)
  Nakajima H, Hosen N(4番目), et al(16名)
- Journal Title
  
  Vaccine
  
  Volume: 30(4) Pages: 722-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] CD 48 as a novel molecular target for antibody therapy in multiple myeloma2012
- Author(s)
  Hosen N, Ichihara H, Mugitani A, et al
- Journal Title
  
  Br J Haematol
  
  Volume: 156(2) Pages: 213-224
- NAID
  40019458257
- Data Source
  KAKENHI-PROJECT-23591386
[Journal Article] CD48 as a novel molecular target for antibody therapy in multiple myeloma2012
- Author(s)
  Hosen N(1番目), et al(20名)
- Journal Title
  
  Leukemia
  
  Volume: 156(2) Pages: 213-224
- NAID
  40019458257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8^+ T cells in patients with solid tumors and healthy donors2012
- Author(s)
  Morimoto S., et al
- Journal Title
  
  Cancer Science
  
  Volume: 103 Issue: 3 Pages: 408-414
- DOI
  10.1111/j.1349-7006.2011.02163.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590991, KAKENHI-PROJECT-21591205, KAKENHI-PROJECT-21591870, KAKENHI-PUBLICLY-22103508, KAKENHI-PROJECT-22700896, KAKENHI-PROJECT-23390364, KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-23592148, KAKENHI-PROJECT-24592160
[Journal Article] CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients2012
- Author(s)
  Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, Mugitani A, Ichihara H, Aoyama Y, Nishida S, Tsuboi A, Fujiki F, Tatsumi N, Nakajima H, Hino M, Kimura T, Yata K, Abe M, Oka Y, Oji Y, Kumanogoh A, Sugiyama H.
- Journal Title
  
  Leukemia
  
  Volume: (in press) Issue: 9 Pages: 2135-2141
- DOI
  10.1038/leu.2012.80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591205, KAKENHI-PUBLICLY-23130509, KAKENHI-PROJECT-23591386, KAKENHI-PROJECT-23591390, KAKENHI-PROJECT-23790622
[Journal Article] WT1 Peptide Therapy for a Patient with Chemotherapy-resistant Salivary Gland Cancer2012
- Author(s)
  Shirakata T, Hosen N(4番目), et al(11名)
- Journal Title
  
  Anticancer Res
  
  Volume: 32(3) Pages: 1081-1085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] CD 138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients2012
- Author(s)
  Hosen N, Matsuoka Y, Kishida S, et al
- Journal Title
  
  Leukemia
  
  Volume: 26(9) Pages: 2135-2141
- Data Source
  KAKENHI-PROJECT-23591386
[Journal Article] Biased usage of T cell receptorβ-chain variable region genes of Wilms' tumor gene(WT1)-specific CD8(+) T cells in patients with solid tumors and healthy donors2011
- Author(s)
  Morimoto S, Hosen N(7番目), Kagawa N(16番目), Hashimoto N(17番目), Yoshimine T(18番目), et al(21名)
- Journal Title
  
  Cancer Science
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse : successful maintenance of durable remission2011
- Author(s)
  Hashii Y, Hosen N(7番目), et al(12名)
- Journal Title
  
  Leukemia
  
  Volume: 26(3) Pages: 530-532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] Long-term WT1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease2011
- Author(s)
  Tuboi A、Hosen N(11番目), et al(13名)
- Journal Title
  
  Leukemia
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] CD166/Activated leukocyte cell adhesion molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion2011
- Author(s)
  Noriyuki Kijima
- Journal Title
  
  Neuro-Oncology
  
  Volume: (in press) Issue: 10 Pages: 1254-1264
- DOI
  10.1093/neuonc/nor202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870, KAKENHI-PUBLICLY-22103508, KAKENHI-PROJECT-22659259, KAKENHI-PROJECT-22791343, KAKENHI-PUBLICLY-23130509, KAKENHI-PROJECT-23592123, KAKENHI-PROJECT-23791595, KAKENHI-PROJECT-24592160, KAKENHI-PROJECT-24791499
[Journal Article] CD48 as a novel molecular target for antibody therapy in multiple myeloma.2011
- Author(s)
  Hosen N, Ichihara H, Mugitani A, Aoyama Y, Fukuda Y, Kishida S, Matsuoka Y,Nakajima H, et al
- Journal Title
  
  British Journal of Haematology
  
  Volume: 156 Pages: 213-224
- NAID
  40019458257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591386
[Journal Article] Use of(11) C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2011
- Author(s)
  Chiba Y, Kinoshita M(2番目), Kagawa N(6番目), Hashimoto N(2番目), Hosen N(14番目), Yoshimine T(15番目), et al(15名)
- Journal Title
  
  Journal of Neurosurgery
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] CD166/ Activated leukocyte cell adhesion, molecule is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion2011
- Author(s)
  Kijima N, Hosen N(2番目), Kagawa N(3番目), Hashimoto N(4番目), Yoshimine T(9番目), et al:
- Journal Title
  
  Neuro-Oncology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8+ T cells in bone marrow (BM) in tumor-bearing patients: an important role of BM as a secondary lymphoid organ.2010
- Author(s)
  Murao A, Oka Y, Tsuboi A, Elisseeva OA, Harada Y, Fujiki F, Nakajima H, Nishida S, Hosen N, Shirakata T, Hashimoto N, Myoui A, Ueda T, Takeda Y, Osaki T, Enomoto T, Yoshikawa H, Kimura T, Oji Y, Kawase I, Sugiyama H.
- Journal Title
  
  Cancer Science (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma2010
- Author(s)
  Chiba Y, Hashimoto N(2番目), Kinoshita M(6番目), Kagawa N(7番目), Hosen N(9番目), Yoshimine T(12番目), et al(12名)
- Journal Title
  
  JPN J Clin Oncol
  
  Volume: 40(5) Pages: 395-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591870
[Journal Article] Biased usage of BV gene families of T cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies2010
- Author(s)
  Tanaka-Harada Y, Kawakami M, Oka Y, Tsuboi A, Katagiri T, Elisseeva O, Nishida S, Shirakata T, Hosen N, Fujiki F, Murao A, Nakajima H, Oji Y, Kanda Y, Kawase I, Sugiyama H.
- Journal Title
  
  Cancer Science 101
  
  Pages: 594-600
- NAID
  10026589035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Identification of a WT1 protein-derived peptide, WT1187 as an HLA-A*0206-restricted, WT1-specific CTL epitope" is currently at the following stage of production.2008
- Author(s)
  Li Z, Oka Y, Tsuboi A, Fujiki F, Harada Y, Nakajima H, Masuda T, Fukuda Y, Kawakatsu M, Morimoto S, Katagiri T, Tatsumi N, Hosen N, Shirakata T, Nishida S, Kawakami Y, Udaka K, Kawase I, Oji Y, Sugiyama H.
- Journal Title
  
  Microbiol Immunol 52
  
  Pages: 551-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Journal Article] Th1-biased humoral immune responses against Wilms tumor gene WT1 product in the patients with hematopoietic malignancies.2005
- Author(s)
  Wu F, Oka Y, Tsuboi A, Elisseeva O. A, Nakajima H, Fujiki F, Masuda T, Murakami M, Yoshihara S, Ikegame K, Hosen N, Kawakami M, Nakagawa M, Kubota T, Soma T, Yamagami T, Tsukaguchi M, Ogawa H, Oji Y, Hamaoka T, Kawase I, Sugiyama H.
- Journal Title
  
  Leukemia 19
  
  Pages: 268-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015028
[Patent] 脳腫瘍幹細胞の検出方法2011
- Inventor(s)
  保仙直毅, 杉山治夫, 香川尚己, 吉峰俊樹
- Industrial Property Rights Holder
  保仙直毅, 杉山治夫, 香川尚己, 吉峰俊樹
- Industrial Property Number
  2011-131050
- Filing Date
  2011-06-13
- Data Source
  KAKENHI-PROJECT-21591870
[Patent] 脳腫瘍幹細胞の検出方法2011
- Inventor(s)
  保仙直毅、杉山治夫、香川尚己、吉峰俊樹
- Industrial Property Rights Holder
  保仙直毅、杉山治夫、香川尚己、吉峰俊樹
- Filing Date
  2011-06-13
- Data Source
  KAKENHI-PROJECT-21591870
[Patent] 形質細胞の腫瘍性増殖をきたす疾患の治療薬2010
- Inventor(s)
  保仙直毅
- Industrial Property Rights Holder
  国立大学法人大阪大学杉山治夫
- Filing Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-21790917
[Patent] THERAPEUTIC AGENT FOR DISEASES IN WHICH NEOPLASTIC PROLIFERATION OF PLASMA CELLS OCCURS2010
- Inventor(s)
  保仙直毅, 杉山治夫
- Industrial Property Rights Holder
  大阪大学
- Filing Date
  2010-04-10
- Overseas
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] Establishment of CAR-NK cell therapy targeting B7-H3 against glioblastoma2023
- Author(s)
  Tetsuro Tachi, Noriyuki Kijima, Hideki Kuroda, Shunya Ikeda, Koki Murakami, Ryuichi Hirayama, Yoshiko Okita, Naoki Kagawa, Naoki Hosen, Haruhiko Kishima
- Organizer
  28th Society for Neuro-Oncology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09231
[Presentation] nsights from Trajectories of PIGA-Mutated Clones in Paroxysmal Nocturnal Hemoglobinuria2023
- Author(s)
  Yasutaka Ueda, Jun-ichi Nishimura, Naoki Hosen et al
- Organizer
  The 65th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07859
[Presentation] Identification of a new therapeutic antigen for glioblastoma using a monoclonal antibody library from patient-derived tumor spheres2023
- Author(s)
  Hideki Kuroda, Noriyuki Kijima, Tetsuro Tachi, Shunya Ikeda, Koki Murakami, Ryuichi Hirayama, Yoshiko Okita, Naoki Kagawa, Naoki Hosen, Haruhiko Kishima
- Organizer
  28th Society for Neuro-Oncology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09231
[Presentation] Development of CAR-T cell therapy using xenograft models2022
- Author(s)
  保仙　直毅
- Organizer
  the 6th International Workshop on Humanized Mice
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03710
[Presentation] Identification of target antigens for chimeric antigen receptor T- cell therapy against glioblastoma using a monoclonal antibody library raised against patient-derived tumor spheres2022
- Author(s)
  Noriyuki Kijima, Tomoyoshi Nakagawa, Kana Hasegawa, Shunya Ikeda, Moto Yaga, Tansri Wibowo, Tetsuro Tachi, Hideki Kuroda, Ryuichi Hirayama, Yoshiko Okita, Manabu Kinoshita, Naoki Kagawa, Yonehiro Kanemura, Naoki Hosen, Haruhiko Kishima
- Organizer
  The 27th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
- Data Source
  KAKENHI-PROJECT-22K09231
[Presentation] Identification of target antigens for chimeric antigen receptor T- cell therapy against glioblastoma using a monoclonal antibody library raised against patient-derived tumor spheres2022
- Author(s)
  Noriyuki Kijima, Tomoyoshi Nakagawa, Kana Hasegawa, Shunya Ikeda, Moto Yaga, Tansri Wibowo, Tetsuro Tachi, Hideki Kuroda, Ryuichi Hirayama, Yoshiko Okita, Manabu Kinoshita, Naoki Kagawa, Yonehiro Kanemura, Naoki Hosen, Haruhiko Kishima
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09231
[Presentation] 患者由来初代培養株を用いた膠芽腫の新規免疫治療の開発2022
- Author(s)
  木嶋教行、中川智義、長谷川加奈、黒田秀樹、平山龍一、沖田典子、香川尚己、金村米博、保仙直毅、貴島晴彦
- Organizer
  第22回日本分子脳神経外科学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09231
[Presentation] Identification of target antigens for chimeric antigen receptor T- cell therapy against glioblastoma using a monoclonal antibody library raised against patient-derived tumor spheres2022
- Author(s)
  Noriyuki Kijima, Tomoyoshi Nakagawa, Kana Hasegawa, Shunya Ikeda, Moto Yaga, Tansri Wibowo, Tetsuro Tachi, Hideki Kuroda, Ryuichi Hirayama, Yoshiko Okita, Manabu Kinoshita, Naoki Kagawa, Yonehiro Kanemura, Naoki Hosen, Haruhiko Kishima
- Organizer
  6th Quadrennial Meeting of the World Federation of Neuro-oncology Societies (WFNOS 2022)
- Data Source
  KAKENHI-PROJECT-22K09231
[Presentation] 遺伝子改変T細胞療法.2020
- Author(s)
  保仙直毅.
- Organizer
  第79回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03710
[Presentation] CAR-T cell therapy for multiple myeloma2020
- Author(s)
  保仙直毅.
- Organizer
  第82回日本血液学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03710
[Presentation] CAR-T細胞療法の現状と展望2020
- Author(s)
  保仙　直毅
- Organizer
  第58回日本癌治療学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04810
[Presentation] The Activated Conformation of Integrin β7 is a Novel Multiple Myeloma-Specific Target for CAR T-cell Therapy.2020
- Author(s)
  Naoki Hosen
- Organizer
  2nd European CAR T cell meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04207
[Presentation] The Activated Conformation of Integrin β7 is a Novel Multiple Myeloma-Specific Target for CAR T-cell Therapy.2019
- Author(s)
  Naoki Hosen
- Organizer
  The 24th Congress European Hematology Assocoation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04207
[Presentation] Development of new CAR T cell therapies2019
- Author(s)
  保仙　直毅
- Organizer
  第78回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19477
[Presentation] Identification of multiple myeloma-specific antigens as immunotherapeutic targets2016
- Author(s)
  Naoki Hosen1), Kana Hasegawa1), Yasutaka Aoyama5, Ichihara, Atsuko Mugitani, Takafumi Nakao6, Yamane, Manabe7, Akihiro Tsuboi2), Jun Nakata2), Sumiyuki Nishida3), Yoshihiro Oka4),Yusuke Oji1), Masayuki Hino8, Atsushi Kumanogoh3), Haruo Sugiyama4)
- Organizer
  日本血液学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県、横浜市）
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-26461404
[Presentation] RESPONSEASSESSMENTS IN WT1 PEPTIDE VACCINATION AND LONG TERM RESULTS OF COMOZOLOMIDE THERAPY2014
- Author(s)
  Naoya Hashimoto,Akihiro Tsuboi,Yasuyoshi Chiba,Yoshihiro Oka,Soyoko Morimoto,Hiroko Nakajima,Sumiyuki Nishida,Naoki Hosen,Naoki Kagawa,Yusuke Oji,Toshiki Yoshimine,Haruo Sugiyama
- Organizer
  The7th International Conference on WT1 in human neoplasia
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-04-23
- Data Source
  KAKENHI-PROJECT-24592160
[Presentation] CD48 as a novel molecular target for antibody therapy in multiple myeloma2013
- Author(s)
  保仙直毅
- Organizer
  Keystone Symposium
- Year and Date
  2013-01-30
- Data Source
  KAKENHI-PROJECT-23591386
[Presentation] Origin of the myeloma initiating cells and development of its targeting therapies2012
- Author(s)
  保仙直毅
- Organizer
  日本血液学会総会
- Year and Date
  2012-10-21
- Data Source
  KAKENHI-PROJECT-23591386
[Presentation] Analysis of immune escape in leukemia-initiating cells using mouse leukemia models induced by MLL-fusion oncogene2012
- Author(s)
  保仙　直毅
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  ウェスティンホテル淡路、兵庫
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PUBLICLY-23130509
[Presentation] Clonogenic Multiple Myeloma Cells2012
- Author(s)
  保仙直毅
- Organizer
  日本血液学会国際シンポジウム
- Year and Date
  2012-05-26
- Data Source
  KAKENHI-PROJECT-23591386
[Presentation] Analysis of escape mechanism from tumor immunity in leukemia-initiating cells using mouse leukemia models induced by MLL-ENL oncogenes2012
- Author(s)
  保仙直毅
- Organizer
  幹細胞シンポジウム
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23591386
[Presentation] Retrospective analysis of relation between clinical outcome and molecular classification of medulloblastomas2012
- Author(s)
  Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, and Toshiki Yoshimine
- Organizer
  第30回日本脳腫瘍病理学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24592160
[Presentation] Expression of activated leukocyte cell adhesion molecule (ALCAM) influences prognosis in malignant glioma2012
- Author(s)
  Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, Yasunori Fujimoto, and Toshiki Yoshimine
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24592160
[Presentation] Origin of the myeloma initiating cells and development of its targeting therapies2012
- Author(s)
  Naoki Hosen
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-23591386
[Presentation] Relationship between activated leukocyte cell adhesion molecule and prognosis in malignant glioma2012
- Author(s)
  Naoki Kagawa, Naoki Hosen, Noriyuki Kijima, Ryuichi Hirayama, Hideyuki Arita, Manabu Kinoshita, Naoya Hashimoto, Yasunori Fujimoto, and Toshiki Yoshimine
- Organizer
  第30回日本脳腫瘍病理学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24592160
[Presentation] MMSC-1 as a novel molecular target for antibody therapy in multiple myeloma2010
- Author(s)
  保仙直毅
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] Multiple myeloma progenitor cells exist in CD19^-CD38^<++> plasma cell population2010
- Author(s)
  保仙直毅
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] 腫瘍幹細胞:B細胞性腫瘍幹細胞からの考察(ランチョンセミナー)2010
- Author(s)
  保仙直毅
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] MMSC-1 as a novel molecular target for antibody therapy in multiple myeloma2010
- Author(s)
  保仙直毅、津子、川上学、山上保、村上雅樹、玉置広哉、中尾隆文、藤重夫、中島博子、日野雅之、岡芳弘、杉山治夫
- Organizer
  日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] Clonogenic myeloma progenitor exists in CD19-CD38^<++> plasma cells2010
- Author(s)
  保仙直毅、岸田諭、松岡由和、市原弘善、青山泰孝、麥谷安津子、川上学、山上保、村上雅樹、玉置広哉、中尾隆文、藤重夫、中島博子、日野雅之、岡芳弘、杉山治夫
- Organizer
  日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] 腫瘍幹細胞:B細胞系悪性腫瘍からの考察2010
- Author(s)
  保仙直毅
- Organizer
  第69回日本癌学会総会ランチョンセミナー
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] Multiple myeloma progenitor cells exist in CD19^-CD38^<++> plasma cell population2010
- Author(s)
  保仙直毅
- Organizer
  第52回米国血液学会
- Place of Presentation
  オーランド、米国
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] Identification and targeting of multiple myeloma progenitor cells2010
- Author(s)
  保仙直毅、岸田諭、中田潤、松岡由和、杉山治夫
- Organizer
  幹細胞シンポジウム
- Place of Presentation
  淡路島
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] Clonogenic myeloma progenitor exists in CD19-CD38^<++> plasma cells2010
- Author(s)
  保仙直毅、杉山治夫
- Organizer
  米国血液学会
- Place of Presentation
  オーランド、米国
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] 多発性骨髄腫に対する抗体療法のための新規標的抗原2009
- Author(s)
  保仙直毅、水谷陽介、小林丈二、岸田諭、岡芳弘、川瀬一郎、杉山治夫
- Organizer
  日本造血器腫瘍免疫療法研究会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-08-28
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] グリベックとの併用によるCMLに対するWT1ペプチドワクチン免疫療法2009
- Author(s)
  尾路祐介、岡芳弘、西田純幸、白方俊章、保仙直毅、坪井昭博、中島博子、村尾綾子、杉山治夫
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] MMSC-1 is a novel target molecule for antibody therapy against both multiple myeloma progenitor cells and mature myeloma plasma cells2009
- Author(s)
  保仙直毅
- Organizer
  Gordon Research Conference
- Place of Presentation
  スイス
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] MDSに対するWT1ワクチン療法2009
- Author(s)
  坪井昭博、岡芳弘、川上学、尾路祐介、保仙直毅、西田純幸、米谷昇、杉山治夫
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] MMSC-1 is a novel target molecule for antibody therapy against both multiple myeloma progenitor cells and mature myeloma plasma cells2009
- Author(s)
  保仙直毅
- Organizer
  Gordon Research Conference
- Place of Presentation
  ジュネーブ(スイス)
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21790917
[Presentation] MDS-AMLに対しHLA-A*2402拘束性改変型WT1ペプチドワクチン療法を行い、長期間AMLの再発なく経過している1例2008
- Author(s)
  西田純幸、川上学、坪井昭博、村尾綾子、宮井沙緒里、白方俊章、保仙直毅、尾路祐介、塚口真知子、岡芳弘、杉山治夫
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] グリベックとの併用によるCMLに対するWT1ペプチドワクチン免疫療法2008
- Author(s)
  尾路祐介、白方俊章、岡芳弘、西田純幸、坪井昭博、保仙直毅、杉山治夫
- Organizer
  第89回近畿血液学地方会
- Place of Presentation
  大阪
- Year and Date
  2008-06-21
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] グリベックとの併用によるCMLに対するWT1ペプチドワクチン免疫療法2008
- Author(s)
  尾路祐介、岡芳弘、西田純幸、白方俊章、保仙直毅、高橋和子、村尾綾子、中島博子、坪井昭博、杉山治夫
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] WT1 peptide vaccination at very low-dose for myelodysplastic syndrome.2007
- Author(s)
  Kawakami M, Oka Y, Tsuboi A, Harada Y, Elisseeva OA, Furukawa Y, Hayashi T, Nishida S, Shirakata T; Hosen N, Nakajima H, Yamagami T, Soma T, Oji Y, Sugiyama H.
- Organizer
  3rd International Conference on WT1 in Human Malignancies
- Place of Presentation
  Berlin
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-17015028
[Presentation] 神経膠芽腫におけるCD166発現とsubventricular zoneとの関係-再発形式と予後への影響
- Author(s)
  香川尚己、木嶋教行、保仙直毅、平山龍一、千葉泰良、高野浩司、木下学、中西克彦、永野大輔、福屋章悟、藤本康倫、橋本直哉、吉峰俊樹
- Organizer
  日本脳腫瘍学会学術集会
- Place of Presentation
  フェニックスシーガイアリゾート（宮崎）
- Data Source
  KAKENHI-PROJECT-24592160

1. KAGAWA Naoki (50444542)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. 新谷康 (90572983)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 木村亨 (90580796)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. HASHIMOTO Naoya (90315945)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
5. 西村純一 (80464246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 植田康敬 (30533848)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 木嶋教行 (80534627)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
8. 福島健太郎 (70546879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 舟木壮一郎 (50464251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 渡部直史 (90648932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SUGIYAMA Haruo (70162906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
12. OKA Yoshihiro (20273691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
13. OJI Yusuke (20294100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
14. FUJIKI Fumihiro (40456926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. YOSHIMINE Toshiki (00201046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. KINOSHITA Manabu (40448064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. Nakaoka Yoshikazu (90393214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SHIRAI MIKIYASU (70162758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Uchiyama Susumu (90335381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大戸梅治 (90451856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高森弘之 (80792077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 南谷泰仁 (60451811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 藤岡龍哉 (70403045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 松岡由和 (70533420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 上田智朗 (60747517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 杉浦裕典 (30982029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 草壁信輔 (50747186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 一井倫子 (30633010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 寛島隆史 (90966673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. YOKOTA Takahumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. TSUBOI Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. CHIBA Yasuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 森本創世子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 稲垣薫克

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 柴山浩彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

hosen naoki 保仙 直毅

HOSEN Naoki 保仙 直毅

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腫瘍微小環境をmodifyするデザイナー免疫細胞の開発Principal Investigator

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血液がん患者体内で増殖し長期間生存するCAR-T細胞の単離とその制御分子の同定Principal Investigator

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自己糖鎖認識機構の制御によりがん認識能を増強したCAR-NK細胞の開発Principal Investigator

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免疫監視能強化CAR-NK細胞を用いた がんの再発予防法の開発Principal Investigator

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Development of a new CAR-NK cell derived from cord bloodPrincipal Investigator

hosen naoki 保仙直毅

HOSEN Naoki 保仙直毅

免疫監視能強化CAR-NK細胞を用いたがんの再発予防法の開発Principal Investigator