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SHIRAI Mikiyasu  白井 幹康

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Researcher Number 70162758
Other IDs
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Affiliation (based on the past Project Information) *help 2019: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
2016 – 2018: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員
2016: 国立循環器病研究センター, 研究所, 特任研究員
2016: 国立循環器病研究センター, 肺高血圧症先端医学研究部, 特任研究員
2015: 国立研究開発法人国立循環器病研究センター, 研究所, 部長 … More
2014 – 2015: 独立行政法人国立循環器病研究センター, 心機能生理部, 部長
2014: 独立行政法人国立循環器病研究センター, 部長
2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 部長
2013: 国立循環器病研究センター, 心臓生理機能部, 部長
2012 – 2013: 独立行政法人国立循環器病研究センター, その他部局等, その他
2011: 国立循環器病研究センター, 心臓生理機能部, 部長
2011: 独立行政法人国立循環器病研究センター研究所, 心臓生理機能部, 部長
2010 – 2011: Hiroshima International University, 心臓生理機能部, 部長
2009: National Cardiovascular Center Research Institute, 心臓生理部, 部長
2008: Hiroshima International University, 保健医療学部, 教授
2004 – 2006: 広島国際大学, 保健医療学部, 教授
1989 – 2003: 国立循環器病センター研究所, 心臓生理部, 室長
1997: National Cardiovascular Center Research Institute, Cardiac Physiology, Director, 心臓生理部, 室長
1995: 国立循環器病センター研究所, 心臓生理部, 研究 室長
1994: 国立循環器病センター研究所心臓生理部, 室長
1993 – 1994: 国立循環器病センター研究所, 室長 Less
Review Section/Research Field
Principal Investigator
General physiology / Cardiovascular medicine / Circulatory organs internal medicine / Environmental physiology (including Physical medicine and Nutritional physiology) / Neurophysiology and muscle physiology / General physiology
Except Principal Investigator
General physiology / Emergency medicine / Cardiovascular medicine / Respiratory organ internal medicine … More / Legal medicine / Thoracic surgery / Circulatory organs internal medicine / Cardiovascular medicine / General physiology Less
Keywords
Principal Investigator
肺高血圧 / 低酸素性肺血管収縮 / 循環器・高血圧 / hypoxic pulmonary vasoconstriction / 心筋収縮タンパク質 / 放射光 / ラット / 低酸素 / 心筋梗塞 / グレリン … More / ムスカリン性アセチルコリン受容体 / 不整脈 / 低酸素性肺高血圧 / 肺交感神経 / 心拍変動 / 間歇的低酸素 / 肺循環 / 微小循環 / 肺高血圧症 / 血管口径 / 放射光X線回折法 / クロスブリッジ動態 / X線回折法 / 小角散乱 / ナノテクノロジー / 高血圧ラット / 心肥大 / 心筋収縮タンパク / ミオシン間距離 / βアドレナリン受容体刺激 / リアノジン / 細胞内Ca^<2+>放出機構 / 生体内拍動心臓 / 出血性低血圧 / 睡眠時無呼吸症候群 / 交感神経 / βアドレナリン受容体 / Rho-kinase / 心臓交感神経 / マウス肺血管造影 / β-アドレナリン受容体 / 副腎 / 心不全 / 拡張型心筋症 / 心臓自律神経活動 / 心臓マイクロダイアリシス / 慢性心不全 / 心臓リモデリング / 冠循環 / 橋渡し研究 / 高血圧 / 交感神経活動 / 心臓血管中枢 / 延髄微小循環 / 高血圧自然発症ラット / 肺交感神経活動 / 内因性一酸化窒素 / 外因性吸入一酸化窒素 / 一酸化窒素合成阻害薬 / 肺微小循環 / モノクロタリン / 肺血管口径 / 急性肺高血圧 / 慢性肺高血圧 / 肺胞性低酸素 / 吸入一酸化窒素 / L-アルギニン / endogenous nitric oxide / exogenous inhaled nitric oxide / nitric oxide synthase inhibitor / pulmonary microcirculation / pulmonary hypertension / monocrotaline / vascular internal diameter / 筋性肺動脈 / 弾性肺動脈 / 一酸化窒素合成酵素 / カリウムチャネル / 慢性低酸素性肺高血圧 / 免疫組織化学 / 肺小葉 / 肺細葉 / 肺小血管 / 一酸化窒素 / プロスタサイクリン / 電位依存性カリウムチャネル / カルシウム活性化カリウムチャネル / 4-アミノピリジン / イベリオトキシン / pulmonary circulation / muscular pulmonary arteries / elastic pulmonary arteries / nitric oxide synthase / K^+ channel / chronic hypoxic pulmonary hypertension / microcirculation / テレメトリー計測 / プロスタサイクリン欠損マウス / ムスカリン受容体欠損マウス / 微小血管造影術 / アドレノメデュリン / 心筋クロスブリッジ動態 / M_2ノックアウトマウス / 呼吸性変動 / 運動 / 化学受容器反射 / 神経型一酸化窒素合成酵素 / α_2アドレナリン受容体 / 心拍応答 / 換気応答 / 覚醒下無拘束小動物 / 呼吸機能 / 酸素消費量 / 二酸化炭素排出量 / 微小血管造影 / telemetry / prostacyclin KO mouse / muscarinic receptor KO mouse / microangiography / adrenomedullin / synchrotron X-ray diffraction / cardiac crossbridge dynamics / 生理学 / マクロファージ / 糖尿病 / 心臓拡張機能障害 / 心筋拡張機能障害 / 放射光X線回折法 … More
Except Principal Investigator
酸化ストレス / ヘモグロビン / 心臓交感神経活動 / 微小循環 / 酸素 / 外呼吸 / 内呼吸 / 水素 / 心不全 / 肺高血圧 / 一酸化窒素 / 虚血 / 人工酸素運搬体 / 再灌流障害 / 肺高血圧症 / 炎症 / interleukin-6 / interleukin-21 / サイトカイン / 心筋組織間ノルエピネフリン / Myocardial interstitial norepinephrine / Lung Transplantation / 救急蘇生学 / 人工赤血球 / 脳梗塞 / 創傷治癒 / 虚血・再還流 / 酸素ラジカル / ナノバイオ / 救命 / 救急 / エネルギー代謝 / 薬理学 / 老化 / 肺循環障害 / 生活習慣 / 水素ガス / 水素水 / 熱電型水素センサ / モノクロタリン肺高血圧症 / 急性一酸化炭素中毒 / 睡眠時無呼吸症候群 / 間歇低酸素暴露 / オートファジー / アルギナーゼ / 間歇低酸素 / 高血圧 / 加齢 / 閉経 / 間歇的低酸素 / 心機能障害 / 性差医学 / 歯学 / 認知機能障害 / 低酸素 / ユビキチン化 / β-アドレナリン受容体 / 酸素代謝障害 / 一酸化炭素中毒 / シアン中毒 / 人工酸素運搬対 / 再還流障害 / Th17細胞 / M2マクロファージ / interleukin-6受容体抗体 / インターロイキン6 / インターロイキン6受容体抗体 / 冠循環 / 軟X線TVシステム / 冠動脈内径 / 神経性調節 / 冠周圍神経活動 / 心筋組織間ノルエピネフリン濃度 / 神経調節 / 冠周囲神経活動 / 冠動脈口径 / Coronary Circulation / Soft X ray TV system / Coronary diameter / Neural control / Pericoronary nerve activity / 心臓迷走神経 / 心筋組織間アセチールコリン / 心筋虚血 / 肺血管口径 / 心臓交威神経 / α,β,γ-ブロッカー / 心表面血流量 / 心臓組織間アセチールコリン / Total Cardiac Sympathetic Nerve Activity / Synchronized CSNA / Nunber of Activated fivers' / Interstitial Norepinephrine Level / Ishemic region / Cardiac Reflex / Cardiac Sympathetic nerve activity / Cardiac vagal nerve / Myocardial interstitial acetylcholine / Myocardial ishemia / Diameter of Puhuonary vessels. / 軟X線血管造影 / 骨格筋微小血管 / 交感神経 / コリン作動性血管拡張 / X-ray angiography / skeletal muscle / small artery / sympathetic nerve / cholinergic / vasodilation / nitric oxide / 心臓興奮リズム / 自律神経性調節 / 随意行動 / 自律神経遮断薬 / 24時間 / 腎臓交感神経活動 / cardiac sympathetic nerve activity / cardiac rhythm / autonomic control / behavior / autonomic blocker / 24-hour / renal sympathetic nerve activity / 肺移植 / 神経再生 / 感染症 / 生体防禦 / 咳反射 / HeringーBreuer反射 / CGRP / Substance-P / 生体防術 / Hering-Breuer反射 / Afferent Denervation / Reinnervation / Neuropeptide / Substance P / Vagus nerve / Defense Reflex / Afferent Reinnervation / Cough / Infection / Local Defense Mechanism / 自律神経性制御 / 心拍数 / 毎分心拍出量 / 一回心拍出量 / 末梢血管抵抗 / 動脈血圧 / 日常24時間 / 神経性制御 / 抹消血管抵抗 / Cardiac sympathetic nerve activity / Autonomic nerve control / Heart rate / Stroke volume / Cardiac output / Arterial blood pressure / Total peripheral Resistance / 24-hour period / プラズマX線 / 微小血管造影法 / X線レーザー / 新生血管 / 遺伝子治療 / プラズマx線 / x線レーザー / Quasi-monocromatic X-ray / Plasma x-ray / Microangiography / Regeneration gtherapy / Myocardial ischemia / Myocardial infarction / Microvessels / Diabetic vasculopathy / 拡張型心筋症 / 迷走神経活動 / ノックインマウス / 突然死 / 心機能 / 肺動脈性肺高血圧症 / 高安動脈炎 / IL-6 / IL-21 / トランスジェニックマウス / heart failure / hypertrophy / hypoxia / Ca2+-binding protein / 心肥大 / Ca2+結合蛋白質 / 低酸素負荷 / CHP3欠損マウス / NHE1 / Ca2+シグナル / ベータ遮断薬 / CHP3 / 一酸化炭素 / 虚血再灌流障害 / アポトーシス / 抗炎症作用 / 臓器虚血 / 循環 Less
  • Research Projects

    (25 results)
  • Research Products

    (189 results)
  • Co-Researchers

    (108 People)
  •  Role of pulmonary sympathetic nerves in the regulation of the pulmonary circulation by beta-receptors on pulmonary macrophages during chronic intermittent hypoxiaPrincipal Investigator

    • Principal Investigator
      SHIRAI Mikiyasu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Synchrotron radiation investigation of cardiac contractile protein dynamics at end diastole in a type 2 prediabetes model ratPrincipal Investigator

    • Principal Investigator
      SHIRAI Mikiyasu
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  拡張型心筋症の心臓迷走神経性病態の解明と新規治療薬の開発に関する研究Host Researcher

    • Host Researcher
      白井 幹康
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Molecular mechanism of Vasculitis and Pulmonary arterial hypertension via inflammatory cytokines

    • Principal Investigator
      Nakaoka Yoshikazu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Study on the drug exercise therapy that is effective for cardiac hypertrophy heart failure that develops in Ca2 + load model mouse

    • Principal Investigator
      JIN MEIHUA
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Experimental approach to respiratory and circulatory failure using artificial oxygen carriers and their derivatives

    • Principal Investigator
      KAWAGUCHI Akira
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Emergency medicine
    • Research Institution
      Tokai University
  •  Role of microvascular dysfunction in the cardiovascular center for development of hypertensionPrincipal Investigator

    • Principal Investigator
      Shirai Mikiyasu
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  The novel therapeutic strategy for pulmonary hypertension targeting inflammation amplification loop mediated by IL-6

    • Principal Investigator
      NAKAOKA YOSHIKAZU
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Innovative Approaches for Oxygen Metabolism Disorder with Artificial Oxygen Carriers and Related Compounds

    • Principal Investigator
      KAWAGUCHI Akira
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Emergency medicine
    • Research Institution
      Tokai University
  •  Study on sudden cardiovascular death in animal model of sleep apnea syndrome

    • Principal Investigator
      YOSHIDA Ken-ichi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Legal medicine
    • Research Institution
      The University of Tokyo
  •  Fundamental study on developing heart failure treatment targeting the central nervous system.Principal Investigator

    • Principal Investigator
      SIRAI Mikiyasu
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Breath hydrogen as a possible anti-oxidative stress marker against hydroxyl radicals

    • Principal Investigator
      SHIMOUCHI Akito
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Utility of Innovative Artificial Oxygen Carriers for Diseases Derived From Circulatory Derangements

    • Principal Investigator
      KAWAGUCHI Akira
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Emergency medicine
    • Research Institution
      Tokai University
  •  Neural regulatory mechanisms of cardiopulmonary function in hypoxic conditions.Principal Investigator

    • Principal Investigator
      SHIRAI Mikiyasu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      Hiroshima International University
  •  放射光を用いた心筋クロスブリッジ動態の実時間解析法の確立と臨床応用Principal Investigator

    • Principal Investigator
      白井 幹康
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Hiroshima International University
  •  Development of in-house microangiography using high-intensity quasi-monochromatic x-ray Irradiation from the linear plasma target

    • Principal Investigator
      MORI Hidezo
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Integrative studies on the control of circulation and respiration.Principal Investigator

    • Principal Investigator
      SHIRAI Mikiyasu
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Cardiac sympathetic nerve control of cardiac output during 24-hour period

    • Principal Investigator
      MATSUKAWA Kanji
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Hiroshima University
  •  Segmental differences in the mechanism of vascular tone regulation along the serially-connected pulmonary vessels in vivoPrincipal Investigator

    • Principal Investigator
      SHIRAI Mikiyasu
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Role Of endogenous nitoric oxide in regulating pulmonary microvascular tone in normal and pulmonary hypertensive animalsPrincipal Investigator

    • Principal Investigator
      SHIRAI Mikiyasu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Cardiac sympathetic control of heart excitation rhythm in conscious cats

    • Principal Investigator
      MATSUKAWA Kanji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      HIROSHIMA UNIVERSITY
      National Cardiovascular Center Research Institute
  •  Afferent Reinnervation After Lung Transplantation in the Rat

    • Principal Investigator
      KAWAGUCHI Akira
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Tokai Uniersity School of Medicine
      National Cardiovascular Center Research Institute
  •  Neural control of skeletal muscle small arteries in the cat

    • Principal Investigator
      MATSUKAWA Kanji
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Study on neural factors regulating coronary flow distribution.

    • Principal Investigator
      NINOMIYA Ishio
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      HIROSHIMA UNIVERSITY
      National Cardiovascular Center Research Institute
  •  Basic Research of Neural Control of Coronary Circulation.

    • Principal Investigator
      NINOMIYA Ishio
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Center Research Instutite

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2006 Other

All Journal Article Presentation Book

  • [Book] SPring-8 Research Frontiers 20102011

    • Author(s)
      Schwenke DO, Umetani K, and Shirai, M
    • Total Pages
      2
    • Publisher
      財団法人高輝度光科学研究センター
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Book] SPring-8 Research Frontiers 2010. 財団法人高輝度光科学研究センター編集2011

    • Author(s)
      Schwenke DO, Umetani K, and Shirai M.
    • URL

      http://www.spring8.or.jp/pdf/en/res_fro/10/036-037.pdf

    • Data Source
      KAKENHI-PROJECT-23650213
  • [Book] 「からだと酸素の事典」酸素ダイナミクス研究会編(低酸素性肺血管攣縮)2009

    • Author(s)
      下内章人, 白井幹康
    • Total Pages
      3
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Book] 低酸素性血管攣縮2009

    • Author(s)
      下内章人,白井幹康
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Book] 低酸素性血管攣縮(酸素ダイナミクス研究会「からだと酸素の事典」)(高橋英嗣、精山明敏編集)2009

    • Author(s)
      下内章人, 白井幹康
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on a High-Salt Diet.2019

    • Author(s)
      Sukumaran V, Tsuchimochi H, Sonobe T, Shirai M, Pearson JT
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 363(3) Pages: 375-388

    • DOI

      10.1124/jpet.118.254821

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Journal Article] Progressive Decrease in Coronary Vascular Function Associated With Type 2 Diabetic Heart Disease.2018

    • Author(s)
      Katare R, Pearson JT, Lew JK, Wei M, Tsuchimouchi H, Du CK, Zhan DY, Umetani K, Shirai M, Schwenke DO
    • Journal Title

      Front Physiol.

      Volume: 9 Pages: 1-11

    • DOI

      10.3389/fphys.2018.00696

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K08514
  • [Journal Article] Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats.2017

    • Author(s)
      Kainuma S, Miyagawa S, Fukushima S, Tsuchimochi H, Sonobe T, Fujii Y, Pearson JT, Saito A, Harada A, Toda K, Shirai M, Sawa Y.
    • Journal Title

      PLoS One

      Volume: 12(8)

    • DOI

      10.1371/journal.pone.0183323

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
  • [Journal Article] Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE-2/ANG 1-7/Mas receptor cascade.2017

    • Author(s)
      Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M, Pearson JT.
    • Journal Title

      Biochem Pharmacol

      Volume: 144 Pages: 90-99

    • DOI

      10.1016/j.bcp.2017.07.022

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
  • [Journal Article] Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet induced obesity with alteration of energy expenditure.2017

    • Author(s)
      Hino J, Nakatani M, Arai Y, Tsuchida K, Shirai M, Miyazato M, Kangawa K
    • Journal Title

      Int J Obes (Lond)

      Volume: 41 Pages: 483-488

    • DOI

      10.1038/ijo.2017.15

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05306, KAKENHI-PROJECT-16K08599, KAKENHI-PROJECT-17K11041, KAKENHI-PROJECT-16H05126
  • [Journal Article] Vagal denervation inhibits the increase in pulmonary blood flow during partial lung aeration at birth.2017

    • Author(s)
      Lang JA, Pearson JT, Binder-Heschl C, Wallace MJ, Siew ML, Kitchen MJ, Te Pas AB, Lewis RA, Polglase GR, Shirai M, Hooper SB.
    • Journal Title

      J Physiol.

      Volume: 595(5) Pages: 1593-1606

    • DOI

      10.1113/jp273682

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
  • [Journal Article] Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion2017

    • Author(s)
      Du CK, Zhan DY, Akiyama T, Inagaki T, Shishido T, Shirai M, Pearson JT.
    • Journal Title

      Am J Physiol

      Volume: 312(1)

    • DOI

      10.1152/ajpheart.00471.2016

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-16K15452
  • [Journal Article] Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation2017

    • Author(s)
      Zhan DY, Du CK, Akiyama T, Morimoto S, Shimizu S, Kawada T, Shirai M, Pearson JT.
    • Journal Title

      Auton Neurosci

      Volume: 205 Pages: 33-40

    • DOI

      10.1016/j.autneu.2017.03.002

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-17K11604, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-16K15452
  • [Journal Article] Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography.2017

    • Author(s)
      Torii M, Fukui T, Inoue M, Kanao S, Umetani K, Shirai M, Inagaki T, Tsuchimochi H, Pearson JT, Toi M.
    • Journal Title

      J Synchrotron Radiat

      Volume: 24 Pages: 1039-1047

    • DOI

      10.1107/s1600577517008372

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16033, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
  • [Journal Article] Effect of hydroxyethyl starch priming on the systemic inflammatory response and lung edema following cardiopulmonary bypass in a rat model.2017

    • Author(s)
      Fujii Y, Tanabe T, Yamashiro T, Shirai M, Takewa Y, Tatsumi E.
    • Journal Title

      ASAIO J.

      Volume: 63(5) Pages: 618-623

    • DOI

      10.1097/mat.0000000000000543

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452, KAKENHI-PROJECT-15K21692
  • [Journal Article] Widespread coronary dysfunction in the absence of HDL receptor SR-B1 in an ischemic cardiomyopathy mouse mode2017

    • Author(s)
      Pearson JT, Yoshimoto M, Chen YC, Sultani R, Edgley AJ, Nakaoka H, Nishida M, Umetani K, Waddingham MT, Jin HL, Zhang Y, Kelly DJ, Schwenke DO, Inagaki T, Tsuchimochi H, Komuro I, Yamashita S, Shirai M.
    • Journal Title

      Sci Rep.

      Volume: Dec 22;7(1) Pages: 1-13

    • DOI

      10.1038/s41598-017-18485-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16033, KAKENHI-INTERNATIONAL-15K21716, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-17H02100, KAKENHI-PROJECT-16K15452
  • [Journal Article] 遺伝性拡張型心筋症に対する新規治療法の開発に向けて2016

    • Author(s)
      戦 冬雲、杜 成坤、森本 幸生、秋山 剛、Daryl O. Schwenke、細田 洋司、寒川 賢治、白井 幹康、Pearson James
    • Journal Title

      BIO Clinica

      Volume: 31 Pages: 101-104

    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Journal Article] Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion in rats.2016

    • Author(s)
      Tadakatsu Inagaki, Tsuyoshi Akiyama, Cheng-Kun Du, Dong-Yun Zhan, Misa Yoshimoto & Mikiyasu Shirai
    • Journal Title

      Free Radic Res

      Volume: 50 Pages: 645-653

    • DOI

      10.3109/10715762.2016.1162300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-26860165, KAKENHI-PROJECT-16K08514
  • [Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin resistant Goto-Kakizaki rats.2016

    • Author(s)
      Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R426-39.

      Volume: 311(2) Pages: 426-439

    • DOI

      10.1152/ajpregu.00112.2016

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-26860165, KAKENHI-PROJECT-16K15452, KAKENHI-PROJECT-15K21692
  • [Journal Article] SPring-8 synchrotron radiation imaging for analyzing cardiovascular function in anesthetized small animals2016

    • Author(s)
      Shirai M, Yagi N, Umetani K.
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 148(2) Issue: 2 Pages: 92-99

    • DOI

      10.1254/fpj.148.92

    • NAID

      130005253974

    • ISSN
      0015-5691, 1347-8397
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
  • [Journal Article] Acute arterial baroreflex-mediated changes in plasma catecholamine concentrations in a chronic rat model of myocardial infarction2016

    • Author(s)
      Kawada T, Akiyama T, Li M, Zheng C, Turner MJ, Shirai M, Sugimachi M.
    • Journal Title

      Physiol Rep

      Volume: 4(15)

    • DOI

      10.14814/phy2.12880

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-26461099, KAKENHI-PROJECT-26462774
  • [Journal Article] Ghrelin supresses sympathetic hyper-excitation in acute heart failure in male rats - assessing centrally and peripherally mediated pathways2015

    • Author(s)
      Shirai M, Joe N, Tsuchimochi H, Sonobe T, Schwenke DO.
    • Journal Title

      Endocrinology

      Volume: 156 Pages: 3309-3316

    • DOI

      10.1210/en.2015-1333

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Journal Article] 生理活性ペプチドを用いた拡張型心筋症の新規治療法の開発2015

    • Author(s)
      戦 冬雲, 杜 成坤, 秋山 剛, 白井 幹康.
    • Journal Title

      Medical Science Digest

      Volume: 41(13) Pages: 476-479

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Journal Article] Interleukin-6/Interleukin-21-signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.2015

    • Author(s)
      Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M, Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K, Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, and Nakaoka Y
    • Journal Title

      Takayasu arteritis and ulcerative colitis-high concurrence ratio and genetic overlap.

      Volume: Early Edition Pages: 1-10

    • DOI

      10.1073/pnas.1424774112

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-15K01712, KAKENHI-PROJECT-15K15309, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25293183
  • [Journal Article] Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits.2015

    • Author(s)
      Shimizu S, Kawada T, Akiyama T, Turner MJ, Shishido T, Kamiya A, Shirai M, Sugimachi M.
    • Journal Title

      Auton Neurosci

      Volume: 187 Pages: 84-87

    • DOI

      10.1016/j.autneu.2014.11.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-26750153
  • [Journal Article] Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension2015

    • Author(s)
      Waddingham MT, Edgley AJ, Astolfo A, Inagaki T, Fujii Y, Du CK, Zhan DY, Tsuchimochi H, Yagi N, Kelly DJ, Shirai M, Pearson JT.
    • Journal Title

      Cardiovasc Diabetol.

      Volume: 14 Pages: 92-105

    • DOI

      10.1186/s12933-015-0256-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21692, KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25860184
  • [Journal Article] readmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography.2015

    • Author(s)
      Sonobe T, Tsuchimochi H, Schwenke DO, Pearson JT, Shirai M.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 13

    • DOI

      10.1186/s12933-015-0217-0

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Journal Article] Pulmonary macrophages attenuate hypoxic pulmonary vasoconstriction via β3AR/iNOS pathway in rats exposed to chronic intermittent hypoxia.2015

    • Author(s)
      Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Sayoko Ogura, Takashi Sonobe, Tadakatsu Inagaki, Yutaka Fujii, Rutsuko Yamaguchi, Lisa Wingenfeld, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, Koichi Uemura, James T. Pearson, Mikiyasu Shirai
    • Journal Title

      PLoS One.

      Volume: 10 Pages: 1-20

    • DOI

      10.1371/journal.pone.0131923

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26461262
  • [Journal Article] APJ Regulates Parallel Alignment of Arteries and Veins in the Skin2015

    • Author(s)
      Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N.
    • Journal Title

      Dev Cell

      Volume: 33 Pages: 247-259

    • DOI

      10.1016/j.devcel.2015.02.024

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14380, KAKENHI-PROJECT-15K18409, KAKENHI-INTERNATIONAL-15K21737, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-26830072, KAKENHI-PROJECT-24300330
  • [Journal Article] Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia2014

    • Author(s)
      Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hisashi Nagai, Emily Gray, James Todd Pearson, Takashi Sonobe, Misa Yoshimoto, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Ichiro Kuwahira, Daryl Schwenke
    • Journal Title

      Basic Res. Cardiol.

      Volume: 109 Pages: 432-432

    • DOI

      10.1007/s00395-014-0432-y

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26670413
  • [Journal Article] β2-Adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats2014

    • Author(s)
      Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Tadakatsu Inagaki, Sayoko Ogura, Yutaka Fujii, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, James T. Pearson, Koichi Uemura, Mikiyasu Shirai
    • Journal Title

      PLoS One.

      Volume: 10 Pages: 1-10

    • DOI

      10.1371/journal.pone.0110693

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26461262, KAKENHI-PROJECT-26670413
  • [Journal Article] Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.2014

    • Author(s)
      Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I
    • Journal Title

      Nature Commun.

      Volume: 5 Pages: 4452-4452

    • DOI

      10.1038/ncomms5552

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24300330, KAKENHI-PUBLICLY-25111705, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-25293183, KAKENHI-PROJECT-25293238, KAKENHI-PROJECT-25670386, KAKENHI-PROJECT-26290035, KAKENHI-PROJECT-26640069, KAKENHI-PROJECT-26670394, KAKENHI-PROJECT-26670396, KAKENHI-PROJECT-24249047
  • [Journal Article] Acute effects of arterial baroreflex on sympathetic nerve activity and plasma norepinephrine concentration.2014

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Sata Y, Turner MJ, Shirai M, Sugimachi M.
    • Journal Title

      Auton Neurosci

      Volume: 186 Pages: 62-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Journal Article] Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart2013

    • Author(s)
      Maeda H, Nagai H, Takemura G, Shintani-Ishida K, Komatsu M, Ogura S, Aki T, Shirai M, Kuwahira I, Yoshida K
    • Journal Title

      Biochim Biophys Acta (molecular basis of disease)

      Volume: 1832(8) Pages: 1159-1166

    • Data Source
      KAKENHI-PROJECT-23249038
  • [Journal Article] In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anesthetized mice.2013

    • Author(s)
      Zhan DY, Du CK, Akiyama T, Sonobe T, Tsuchimochi H, Shirai M.
    • Journal Title

      Autonomic Neuroscience: Basic and Clinical

      Volume: 176(1-2) Pages: 91-94

    • DOI

      10.1016/j.autneu.2013.02.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790791
  • [Journal Article] Impaired pulmonary blood flow distribution in congestive heart failure assessed using synchrotron radiation microangiography2013

    • Author(s)
      Shirai M, Beard M, Pearson JT, Son obe T, Tsuchimochi H, Fujii Y, Gray E, Umetani K. Schwenke DO.
    • Journal Title

      J. Synchrotron Rad.

      Volume: 20(3) Pages: 441-448

    • DOI

      10.1107/s0909049513007413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-25350547
  • [Journal Article] Myosin heads are displaced from actin filaments in the in situ beating rat heart in early diabetes2013

    • Author(s)
      Jenkins MJ, Pearson JT, Schwenke DO, Edgley AJ, Sonobe T, Fujii Y, Ishibashi-Ueda H, Kelly DJ, Yagi N, Shirai M.
    • Journal Title

      Biophys. J.

      Volume: 104 Pages: 1065-1072

    • DOI

      10.1016/j.bpj.2013.01.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086
  • [Journal Article] Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension.2013

    • Author(s)
      Gray EA, Tsuchimochi H, Pearson JT, Sonobe T, Fujii Y, Yoshimoto M, Umetani K, Shirai M, Schwenke DO.
    • Journal Title

      J Synchrotron Radiat.

      Volume: 20(5) Pages: 756-764

    • DOI

      10.1107/s0909049513021213

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23790285, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25871231
  • [Journal Article] Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model2013

    • Author(s)
      Fujii Y, Shirai M, Inamori S, Shimouchi A, Sonobe T, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.
    • Journal Title

      Circ J

      Volume: 37 Pages: 995-1000

    • DOI

      10.1111/j.1525-1594.2012.01535.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-21240057, KAKENHI-PROJECT-21390398, KAKENHI-PROJECT-23659677, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24300168
  • [Journal Article] Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor.2013

    • Author(s)
      Ogura S, Shimosawa T, Mu SY, Sonobe T, Kawakami-Mori F, Wang H, Uetake y. Yoshida K, Yatomi Y, S hirai M, Fujita T.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 305(2)

    • DOI

      10.1152/ajpheart.00169.2012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-21229012, KAKENHI-PROJECT-23249038, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24659410, KAKENHI-PROJECT-24790863
  • [Journal Article] Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischemia-reperfusion in rabbits2013

    • Author(s)
      Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M.
    • Journal Title

      Acta Physiologica

      Volume: 207 Pages: 260-268

    • DOI

      10.1111/j.1748-1716.2012.02461.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790791
  • [Journal Article] Shirai M, Kuwahira I, Yoshida K.. Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart2013

    • Author(s)
      Hideyuki Maeda, Hisashi Nagai, GenzouTakemura, Masaaki Komatsu, Sayoko Ogura, Kaori Shintani-Ishida, Toshihiko Aki, Mikiyasu Shirai, Ichiro Kuwahira, Ken-ichi Yoshida
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1832 Pages: 1159-1166

    • DOI

      10.1016/j.bbadis.2013.02.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590629, KAKENHI-PROJECT-23249038, KAKENHI-PROJECT-23590843, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24659334, KAKENHI-PROJECT-24790863, KAKENHI-PROJECT-25293162
  • [Journal Article] Synchrotron radiation imaging for advancing our understanding of cardiovascular function2013

    • Author(s)
      Mikiyasu Shirai, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Keiji Umetani, Naoto Yagi, James T. Pearson
    • Journal Title

      Circ. Res.

      Volume: 112(1) Pages: 209-221

    • DOI

      10.1161/circresaha.111.300096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500423, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086
  • [Journal Article] Hyperoxic condition promotes an inflammatory responses during cardiopulmonary bypass in a rat model.2013

    • Author(s)
      Fujii Y, Shirai M, Tsuchimochi H, Pearson JT, Takewa Y, Tatsumi E, Taenaka Y.
    • Journal Title

      Artif Organs

      Volume: 37(12) Pages: 1034-1040

    • DOI

      10.1111/aor.12125

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659677, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24300168, KAKENHI-PROJECT-25293294, KAKENHI-PROJECT-25871231
  • [Journal Article] Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation.2013

    • Author(s)
      Pearson JT, Jenkins Mi. Edgley AJ, Sonobe T, Joshi M. Waddingham MT, Fujii V. Schwenkc DO, Tsuchi mochi H. Yoshimoto M, Umetani K, Kelly DJ, Shirai M.
    • Journal Title

      Cardio vascular diabetology.

      Volume: 12 Pages: 111-111

    • DOI

      10.1186/1475-2840-12-111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23790285, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25871231
  • [Journal Article] Effects of intravenous magnesium infusion on in vivo release of acetylcholine and catecholamine in rat adrenal medulla2013

    • Author(s)
      Komaki F, Akiyama T, Yamazaki T, Kitagawa H, Nosaka S, Shirai M.
    • Journal Title

      Auton Neurosci

      Volume: 177 Pages: 123-128

    • DOI

      10.1016/j.autneu.2013.03.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-24249086
  • [Journal Article] Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor2013

    • Author(s)
      Ogura S, Shimosawa T, Mu S, Sonobe T, Kawakami-Mori F, Wang H, Uetake Y, Yoshida K, Yatomi Y, Shirai M, Fujita T
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 305(2)

    • Data Source
      KAKENHI-PROJECT-23249038
  • [Journal Article] Sympathetic Afferent Stimulation Inhibits Central Vagal Activation Induced by Intravenous Medetomidine in Rats.2013

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Turner Michael J, Shirai M, Sugimachi M
    • Journal Title

      Acta Physiol

      Volume: 10 Pages: 100-110

    • DOI

      10.1111/apha.12123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390415, KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-24249086
  • [Journal Article] Establishment of a novel murine model of ischemic cardiomyopathy with multiple diffuse coronary lesions.2013

    • Author(s)
      Nakaoka H, Nakagawa-Toyama Y, N ishida M, Tsubakio-Yamamoto K, Ya mashita T, Nakatani K, Kawase R, Masuda D, Ohama T, Sonobe T, Shirai M, Komuro I, Yamashita S.
    • Journal Title

      PLoS One

      Volume: 8(8)

    • DOI

      10.1371/journal.pone.0070755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-24249086
  • [Journal Article] A comparative study of cerebral microcirculation during pulsatile and nonpulsatile selective cerebral perfusion: assessment by synchrotron radiation microangiography.2013

    • Author(s)
      Inamori S, Shirai M, Yahagi N, Pearson JT, Fujii Y, Umetani K, Kobayashi Y, Okura Y, Yakehiro M, Minamiyama M.
    • Journal Title

      ASAIO J.

      Volume: 59 Pages: 374-379

    • DOI

      10.1097/mat.0b013e3182976939

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-25871231
  • [Journal Article] Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control2012

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M
    • Journal Title

      Circ J

      Volume: 76 Pages: 152-159

    • NAID

      10030034497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Journal Article] Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control.2012

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S, Sugimachi M.
    • Journal Title

      Circ. J.

      Volume: 76 Pages: 152-159

    • NAID

      10030034497

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Journal Article] Central vagal activation by alpha(2)-adrenergic stimulation is impaired in spontaneously hypertensive rats2012

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, et al
    • Journal Title

      Acta Physiologica

      Volume: (in press) Pages: 72-79

    • DOI

      10.1111/j.1748-1716.2012.02439.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11F01705, KAKENHI-PROJECT-23390415, KAKENHI-PROJECT-23592319, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-23700550, KAKENHI-PROJECT-24500565
  • [Journal Article] Dynamic synchrotron imaging of diabetic rat coronary icrocirculation in vivo2012

    • Author(s)
      Jenkins MJ, Edgley AJ, Sonobe T, Umetani K, Schwenke DO, Fujii Y, Brown RD, Kelly DJ, Shirai M, Pearson JT
    • Journal Title

      Thromb. Vasc. Biol.

      Volume: 32 Pages: 370-377

    • DOI

      10.1161/atvbaha.111.237172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-22500423, KAKENHI-PROJECT-23650213
  • [Journal Article] One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction.2012

    • Author(s)
      Schwenke DO, Tokudome T, Kishimoto I, Horio T, Cragg PA, Shirai M, Kangawa K
    • Journal Title

      Endocrinology.

      Volume: 153(5) Pages: 2436-2443

    • DOI

      10.1210/en.2011-2057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24390204, KAKENHI-PUBLICLY-23122525
  • [Journal Article] Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water2012

    • Author(s)
      Shimouchi A, Nose K, Shirai M, Kondo T
    • Journal Title

      Adv Exp Med Biol

      Volume: 737 Pages: 245-50

    • Data Source
      KAKENHI-PROJECT-21659211
  • [Journal Article] Docking protein Gab1 is an essential component of postbatal angiogenesis after ischemia via HGF/c-Met signaling.2011

    • Author(s)
      Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I
    • Journal Title

      Circ. Res.

      Volume: 108 Pages: 664-675

    • DOI

      10.1161/circresaha.110.232223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591101, KAKENHI-PROJECT-23650213
  • [Journal Article] Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits2011

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M
    • Journal Title

      Auton. Neurosci.

      Volume: 162 Pages: 60-65

    • DOI

      10.1016/j.autneu.2011.04.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-21591190, KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213
  • [Journal Article] Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography.2011

    • Author(s)
      Sonobe T, Schwenke DO, Pearson JT, Yoshimoto M, Fujii Y, Umetani K, Shirai M
    • Journal Title

      Journal of Applied Physiology

      Volume: 111 Pages: 75-80

    • DOI

      10.1152/japplphysiol.00205.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-22500423, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-23790285
  • [Journal Article] Exogenous ghrelin improves blood flow distribution in pulmonary hypertension?assessed using synchrotron radiation microangiography2011

    • Author(s)
      Schwenke DO, Gray EA, Pearson JT, Sonobe T, Ishibashi-Ueda H, Campillo I, Kangawa K, Umetani K, Shirai M
    • Journal Title

      Pflugers Arch-Eur J Physiol

      Volume: 462 Pages: 397-406

    • DOI

      10.1007/s00424-011-0992-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-22500423, KAKENHI-PROJECT-23650213
  • [Journal Article] Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/cmet signaling.2011

    • Author(s)
      Shioyama W, Nakaoka Y, Higuchi K, Minami T, Taniyama Y, Nishida K, Kidoya H, Sonobe T, Naito H, Arita Y, Hashimoto T, Kuroda T, Fujio Y, Shirai M, Takakura N, Morishita R, Yamauchi-Takihara K, Kodama T, Hirano T, Mochizuki N, Komuro I.
    • Journal Title

      Circ.Res. 108(6)(Epub)

      Pages: 664-675

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Role of Rho kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.2011

    • Author(s)
      Schwenke, D.O., Pearson, J.T., Sonobe, T., Ishibashi-Ueda H., Shimouchi, A., Kangawa, K. Umetani, K., Shirai, M.
    • Journal Title

      J Appl Physiol. 110(4)

      Pages: 901-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Role of Rho kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension2011

    • Author(s)
      Schwenke DO, Pearson JT, Sonobe T, Ishibashi-Ueda H, Shimouchi A, Kangawa K, Umetani K, Shirai M
    • Journal Title

      J Appl Physiol

      Volume: 110 Pages: 901-908

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Journal Article] Role of Rho kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension.2011

    • Author(s)
      Daryl Schwenke, James Pearson, Takashi Sonobe, Hatsue Ishibashi-Ueda, Akito Shimouchi, Kenji Kangawa, Keiji Umetani, Mikiyasu Shirai
    • Journal Title

      J. Appl. Physiol.

      Volume: 110 Pages: 901-908

    • DOI

      10.1152/japplphysiol.01318.2010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500423, KAKENHI-PROJECT-23650213
  • [Journal Article] Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension2011

    • Author(s)
      Schwenke DO, Pearson JT, Sonobe T, Ishibashi-Ueda H, Shimouchi A, Kangawa K, Umetani K, Shirai M
    • Journal Title

      J Appl Physiol

      Volume: 110 Pages: 901-908

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Journal Article] Imaging on the closed-chest mouse pulmonary circulation using synchrotron radiation micro- angiography.2011

    • Author(s)
      Sonobe T, Schwenke DO, Pearson JT, Yoshimoto M, Fujii Y, Umetani K, Shirai M
    • Journal Title

      J.Appl.Physiol. Epub ahead of print

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits.2011

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M
    • Journal Title

      Auton.Neurosci. Epub ahead of print

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Analysis of breath and skin gases emanating during exercise using an original biogas sampling system connected to an atmospheric pressure ionization mass spectrometer.2010

    • Author(s)
      Shimouchi A., Nose, K., Shirai, M.
    • Journal Title

      IEEE Sensors J. 10(1)

      Pages: 85-91

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Large conductance Ca^<2+>-activated K^+ channels inhibit vagal acetylcholine release at the rabbit sinoatrial node.2010

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Sata Y, Shirai M, Sugimachi M.
    • Journal Title

      Auton.Neurosci. 156(1-2)

      Pages: 149-151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Analysis of breath and skin gases emanating during exercise using an original biogas sampling system connected to an atmospheric pressure ionization mass spectrometer2010

    • Author(s)
      Shimouchi A, Nose K, Shirai M
    • Journal Title

      IEEE Sensors Journal

      Volume: 10 Pages: 85-91

    • Data Source
      KAKENHI-PROJECT-21659211
  • [Journal Article] Analysis of Breath and Skin Gases Emanating during Exercise using an Original Biogas Sampling System connected to an Atmospheric Pressure Ionization Mass Spectrometer.2010

    • Author(s)
      Shimouchi A, Nose K, Shirai M
    • Journal Title

      IEEE Sensors Journal 10

      Pages: 85-91

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Journal Article] Role of Ca^<2+>-activated K+ channels in catecholamine release from in vivo rat adrenal medulla.2010

    • Author(s)
      Akiyama T, Yamazaki T, Kawada T, Shimizu S, Sugimachi M, Shirai M.
    • Journal Title

      Neurochem.Int. 56(2)

      Pages: 263-269

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Exogenous ghrelin accentuates the acute hypoxic ventilatory response after two weeks of chronic hypoxia in conscious rats.2010

    • Author(s)
      Schwenke DO, Pearson JT, Kangawa K, Cragg PA, Shirai M.
    • Journal Title

      Acta Physiol 200

      Pages: 279-287

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Analysis of Breath and Skin Gases Emanating during Exercise using an Original Biogas Sampling System connected to an Atmospheric Pressure Ionization Mass Spectrometer2010

    • Author(s)
      Shimouchi A, Nose K, Shirai M
    • Journal Title

      IEEE Sensors Journal

      Volume: 10 Pages: 85-91

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Journal Article] Contrast angiography of the renal microcirculation in vivo using synchrotron radiation.2009

    • Author(s)
      Eppel, G.A., Jacono, D.L., Shirai, M., Umetani, K., Evans, R.G., Pearson, J.T.
    • Journal Title

      Am.J.Physiol.Renal Physiol. 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Synchrotron-based angiography for investigating regulation of vasomotor function in the microcirculation in vivo.2009

    • Author(s)
      Shirai, M., Schwenke, D.O., Eppel, G.A., Evans, R.G., Edgley, A.J., Tsuchimochi, H., Umetani, K., Pearson J.T.
    • Journal Title

      (Frontiers in Research Review) Clin.Exp.Pharmacol. Physiol. 36

      Pages: 107-116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Changes in pulmonary blood flow distribution in monocrotaline compared with hypoxia-induced models of pulmonary hypertension.2009

    • Author(s)
      Schwenke, D.O., Pearson, J.T., Shimouchi, A., Kangawa, K., Tsuchimochi, H., Umetani, K., Shirai, M., Cragg PA.
    • Journal Title

      J Hypertens. 27(7)

      Pages: 1410-1419

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle : a possible trigger for ischemic preconditioning.2009

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Li M, Shirai M, Sugimachi M.
    • Journal Title

      Life Sci 85

      Pages: 597-601

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Synchrotron-based angiography for investigating regulation of vasomotor function in the microcirculation in vivo.(Frontiers in Research Review)2009

    • Author(s)
      Shirai,M.
    • Journal Title

      Clin.Exp.Pharmacol. Physiol 36

      Pages: 107-116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia - assessed using synchrotron radiation microangiography.2008

    • Author(s)
      Schwenke, D.O., Pearson, J.T., Umetani, K., Kangawa, K., Shirai, M.
    • Journal Title

      J.Appl.Physiol. 104

      Pages: 88-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.2008

    • Author(s)
      Schwenke, D.O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P.A., Kangawa, K.
    • Journal Title

      Endocrinology 149

      Pages: 5172-5176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.2008

    • Author(s)
      Schwenke D.O., Tokudome, T., Shirai, M., Hosoda, H., Horio, T., Kishimoto, I., Kangawa, K.
    • Journal Title

      Endocrinology 149

      Pages: 237-244

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Journal Article] 放射光X線回折法による拍動心臓の収縮蛋白質分子動態のリアルタイム計測とその応用(特集 ナノメディシン・プロジェクト)2006

    • Author(s)
      白井幹康
    • Journal Title

      分子心血管病 7(4)

      Pages: 32-42

    • Data Source
      KAKENHI-PROJECT-16659210
  • [Presentation] Changes in the Right Coronary Microcirculation in Pulmonary Arterial Hypertension.2019

    • Author(s)
      Waddingham MT, Jin H, Sonobe , Tsuchimochi H, Asano R, Shirai M, Ogo T, Pearson JT.
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Liraglutide treatment improves the coronary microcirculation in Zucker obese rats on high-salt diet.2019

    • Author(s)
      Sukumaran V, Tsuchimochi H, Sonobe T, Shirai M, Pearson JT.
    • Organizer
      JCS 2019
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Microangiography Reveals the Protective Role of Liraglutide on Renal Microvascular Impairment in Rats with Metabolic Syndrome.2018

    • Author(s)
      Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M, Pearson JT
    • Organizer
      J Am Soc Nephrol
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Understanding the pathogenesis of diastolic dysfunction: from the whole heart to the level of the myofilament proteins.2018

    • Author(s)
      Waddingham MT, Tsuchimochi H, Sonobe T, Hamdani N, Yagi N, Shirai M, Pearson JT, Ogo T
    • Organizer
      The 2nd JCS Council Forum on Basic CardioVascular Research.
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] 拡張型心筋症ノックインマウスにおける心臓交感神経終末ノルエピネフリン動態異常2017

    • Author(s)
      戦 冬雲、杜 成坤、秋山 剛、森本 幸生、白井 幹康、James T. Pearson
    • Organizer
      第94回日本生理学会大会(浜松)
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Beta-blockade prevents coronary microvascular endothelial dysfunction in non-obese salt-sensitive insulin resistant rats on a high salt diet2017

    • Author(s)
      H Tsuchimochi, H Thambyah, AJ Edgley, T Inagaki, MT Waddingham, YC Chen, CK Du, DY Zhan, V Sukumaran, T Sonobe, K Umetani, M Shirai, JT Pearson
    • Organizer
      ESC Congress 2017(Barcelona)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] 拡張型心筋症ノックインマウスにおける心臓ノルエピネフリン動態異常2017

    • Author(s)
      戦冬雲、杜成坤、秋山剛、森本幸生、白井幹康、ピアソン ジェームズ
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Beta-blockade prevents coronary microvascular endothelial dysfunction in non-obese salt-sensitive insulin resistant rats on a high salt diet.2017

    • Author(s)
      H Tsuchimochi, H Thambyah, AJ Edgley, T Inagaki, MT Waddingham, YC Chen, CK Du, DY Zhan, V Sukumaran, T Sonobe, K Umetani, M Shirai, JT Pearson
    • Organizer
      ESC Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] 拡張型心筋症ノックインマウスにおける心臓ノルエピネフリン動態異常2017

    • Author(s)
      戦 冬雲,杜 成坤,秋山 剛,森本 幸生,白井 幹康,ピアソン ジェームズ
    • Organizer
      第94回日本生理学会総会
    • Place of Presentation
      アクトシティー浜松
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Investigating in vivo myocardial and coronary molecular pathophysiology in mice with X-ray radiation imaging approaches2017

    • Author(s)
      JT Pearson, M Shirai
    • Organizer
      第12回上原国際シンポジウム2017 Make Life Visible
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] 拡張型心筋症ノックインマウスに対するドネペジルの治療効果2017

    • Author(s)
      杜 成坤、戦 冬雲、森本 幸生、秋山 剛、白井 幹康、James T. Pearson
    • Organizer
      第94回日本生理学会大会(浜松)
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Abnormalities of cardiac norepinephrine kinetics in a knock-in mouse model of dilated cardiomyopathy2017

    • Author(s)
      Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, Mikiyasu Shirai, James T Pearson
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] Short term administration of azilsartan ameliorates diabetic cardiomyopathy in db/db mice2017

    • Author(s)
      Sukumaran Vijayakumar, Hirotsugu Tsuchimochi, Mikiyasu Shirai, James T Pearson
    • Organizer
      第94回日本生理学会総会
    • Place of Presentation
      アクトシティー浜松
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Investigating in vivo myocardial and coronary molecular pathophysiology in mice with X-ray radiation imaging approaches2017

    • Author(s)
      JT Pearson, M Shirai
    • Organizer
      第12回上原国際シンポジウム2017 Make Life Visible
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017

    • Author(s)
      JT Pearson, H Tsuchimochi, N Yagi, M Shirai
    • Organizer
      第94回日本生理学会大会(浜松)
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Abnormalities of cardiac norepinephrine kinetics in a knock-in mouse model of dilated cardiomyopathy2017

    • Author(s)
      Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, Mikiyasu Shirai, James T Pearson
    • Organizer
      The 90th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagasaki
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] A Novel Role of Calcineurin B Homologous Protein 3 in Hypoxia-induced Cardiac Hypertrophy and Heart Failure2017

    • Author(s)
      MeiHua Jin, Shigeo Wakabayashi, Soushi Kobayashi, Hirotsugu Tsuchimochi, Mikiyasu Shirai, James T. Pearson, Takeshi Ogo.
    • Organizer
      The 94th Annual Meeting of the Phisiological Society
    • Place of Presentation
      Hamamatu
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15K18975
  • [Presentation] Short term administration of azilsartan ameliorates diabetic cardiomyopathy in db/db mice.2017

    • Author(s)
      Sukumaran Vijayakumar, Hirotsugu Tsuchimochi, Mikiyasu Shirai, James Pearson
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Effect of insulin resistance on compound 21 mediated coronary microvascular dilation in female rats in vivo.2017

    • Author(s)
      JT Pearson, P Meagher, H Tsuchimochi, AJ Edgley, M Yoshimoto, MT Waddingham, YC Chen, KM Mirabito Colafella, LM Hilliard, K Umetani, RE Widdop, M Shirai, KM Denton
    • Organizer
      ESC Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] 低酸素により誘発される心肥大におけるカルシニュリンB用蛋白質3(CHP3)の新しい役割2017

    • Author(s)
      金美花、若林繁夫、古林創史、土持裕胤、白井幹康、ピアソン ジェームズ、大郷剛
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Beneficial effects of donepezil in a knock-in mouse model of dilated cardiomyopathy caused by troponin T mutation2017

    • Author(s)
      Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto, Tsuyoshi Akiyama, Mikiyasu Shirai, James T Pearson
    • Organizer
      The 94th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017

    • Author(s)
      ピアソン ジェームズ,土持 裕胤,八木 直人,白井 幹康
    • Organizer
      第94回日本生理学会総会
    • Place of Presentation
      アクトシティー浜松
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] 拡張型心筋症ノックインマウスにおける心臓交感神経終末ノルエピネフリン動態異常2017

    • Author(s)
      戦 冬雲、杜 成坤、秋山 剛、森本 幸生、白井 幹康、James T. Pearson
    • Organizer
      第94回日本生理学会大会(浜松)
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] 低酸素により誘発される心肥大におけるカルシニュリンB様蛋白質3(CHP3)の新しい役割2017

    • Author(s)
      金 美花,若林 繁夫,古林 創史,土持 裕胤,白井 幹康,ピアソン ジェームズ,大郷 剛
    • Organizer
      第94回日本生理学会総会
    • Place of Presentation
      アクトシティー浜松
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Bolus ghrelin administration ameliorates the inflammatory response and oxidative stress during percutaneous cardiopulmonary support in a rat model.2017

    • Author(s)
      Sukumaran V,&nbsp;Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
    • Organizer
      Experimental Biology meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] 拡張型心筋症ノックインマウスに対するドネペジルの治療効果2017

    • Author(s)
      杜 成坤,戦 冬雲,森本 幸生,秋山 剛,白井 幹康,ピアソン ジェームズ
    • Organizer
      第94回日本生理学会総会
    • Place of Presentation
      アクトシティー浜松
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Liraglutide treatment improves renal vascular function in Zucker rats as visualized by microangiography2017

    • Author(s)
      Sukumaran V,&nbsp;Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
    • Organizer
      American Society of Nephrology meeting Kidney Week 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] Effects of Alzheimer drug Aricept in a knock-in mouse model of dilated cardiomyopathy2017

    • Author(s)
      Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto, Tsuyoshi Akiyama, Mikiyasu Shirai, James T Pearson
    • Organizer
      The 90th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagasaki
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017

    • Author(s)
      ピアソン ジェームズ、土持裕胤、八木直人、白井幹康
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Liraglutide treatment improves renal vascular function in Zucker rats as visualized by microangiography.2017

    • Author(s)
      Sukumaran V,&nbsp;Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
    • Organizer
      American Society of Nephrology meeting Kidney Week 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] 張型心筋症ノックインマウスに対するドネペジルの治療効果2017

    • Author(s)
      杜成坤、戦冬雲、森本幸生、秋山剛、白井幹康、ピアソン ジェームズ
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Bolus ghrelin administration ameliorates the inflammatory response and oxidative stress during percutaneous cardiopulmonary support in a rat model.2017

    • Author(s)
      Sukumaran V,&nbsp;Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
    • Organizer
      Experimental Biology meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126
  • [Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017

    • Author(s)
      JT Pearson, H Tsuchimochi, N Yagi, M Shirai
    • Organizer
      第94回日本生理学会大会(浜松)
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Sympathetic hyper-excitation in obesity and pulmonary hypertension; relevance to the Obesity Paradox2016

    • Author(s)
      Schwenke D, Diong C, Shirai M.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-03-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Presentation] Cardiac vagal control in knock-in mouse model of dilated cardiomyopathy2016

    • Author(s)
      Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Sachio Morimoto, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai, James T Pearson
    • Organizer
      The American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] 心筋トロポニンT突然変異に起因する肥大型心筋症における拡張機能障害のメカニズム2016

    • Author(s)
      杜 成坤、戦 冬雲、森本 幸生、西井 清雅、水上 令子、謝 明芳、土持 裕胤、盧 群偉、秋山 剛、白井 幹康
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] Production of calcineurin B homologous protein 3 knockout mice and analysis of cardiac function2016

    • Author(s)
      Shigeo Wakabayashi,MeiHua Jin, Soushi Kobayashi, Hirotsugu Tsuchimochi, Mikiyasu Shirai
    • Organizer
      The 93th Annual Meeting of the Phisiological Society
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2016-03-22
    • Data Source
      KAKENHI-PROJECT-15K18975
  • [Presentation] 拡張型心筋症における心臓迷走神経調節機構異常と新規治療薬の開発2016

    • Author(s)
      戦 冬雲、杜 成坤、秋山 剛、森本 幸生、清水 秀二、川田 徹、寒川 賢治、白井 幹康
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] Fluorescence imaging guided identification of autonomic nerve fibers and the measurement of their activities in vivo by using Thy1-YFP transgenic mice.2016

    • Author(s)
      Tsuchimochi H, Inagaki T, Shirai M.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-03-22
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Presentation] Exercise training attenuates the development of diabetic cardiomyopathy through modulating inflammation and oxidative stress2016

    • Author(s)
      Sukumaran V, Inagaki T, Tsuchimochi H, Shirai M.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-03-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Presentation] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in young insulin resistant Goto-Kakizaki rats.2016

    • Author(s)
      Perason J, Chen Y, Inagaki T, Fujii, Y, Schwenke D, Edgley A, Umetani K, Zhan Y, Yoshimoto M, Tsuchimochi H, Nagai H, Kuwahira I, Evans R, Shirai M.
    • Organizer
      The 93rd Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Sapporo
    • Year and Date
      2016-03-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Presentation] 心筋トロポニンT突然変異に起因する肥大型心筋症ノックインマウスモデル2016

    • Author(s)
      杜 成坤、戦 冬雲、森本 幸生、西井 清雅、水上 令子、謝 明芳、土持 裕胤、盧 群偉、秋山 剛、白井 幹康
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15F15119
  • [Presentation] Critical protective role of endogenous nitric oxide in established severe pulmonary arterial hypertension in rats.2015

    • Author(s)
      Tanaka M, Abe K, Oka M, Schwenke DO, Shirai M, Kuwahira I, Hirooka Y, Hoka S, Sunagawa K.
    • Organizer
      American Heart Association scientific session
    • Place of Presentation
      Florida
    • Year and Date
      2015-11-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Presentation] The effect of blood contact surface area reduction during extracorporeal circulation in a rat cardiopulmonary bypass model.2015

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, Taenaka Y, Tatsumi E
    • Organizer
      American Society for Artificial Internal Organs 61th Annual Conference
    • Place of Presentation
      Chicago
    • Year and Date
      2015-06-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Presentation] Ghrelin acts directly on the CNS to suppress cardiac sympathetic tone and arrhythmias following acute myocardial infarction in rats2015

    • Author(s)
      Shirai M, Joe N, Tsuchimochi H, Schwenke DO
    • Organizer
      92th Annual Meeting of Japan Physiological Society
    • Place of Presentation
      Kobe International Conference Center
    • Year and Date
      2015-03-21
    • Data Source
      KAKENHI-PROJECT-26670413
  • [Presentation] 低酸素誘発性肺高血圧モデルでIL-6/Th17細胞シグナルは肺血管リモデリングに必須である2013

    • Author(s)
      片岡 崇弘、中岡 良和、曽野部 崇、保仙 直毅、稲垣 薫克、樋口 香織、有田 陽、安居 琢、池岡 邦泰、正木 豪、瀧原 圭子、白井 幹康、小室 一成
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      千里阪急ホテル(大阪府豊中市)
    • Data Source
      KAKENHI-PROJECT-25670386
  • [Presentation] 腎血管性高血圧ラットモデルでの高血圧発症初期における動脈圧と交感神経活動の変化2013

    • Author(s)
      吉本光佐、秋山剛、曽野部崇、藤井豊、三木健寿、白井幹康
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 人工心肺中の高酸素吸送は生体の炎症反応を助長する2013

    • Author(s)
      藤井豊、白井幹康、武輪能明、巽英介、妙中義之
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] Blockade of interleukin-6 signaling prevents hypoxia induced pulmonary hypertension in mice2013

    • Author(s)
      Takahiro Hashimoto-Kataoka, Yoshikazu Nakaoka, Takashi Sonobe, Kaori Higuchi, Yoh Arita, Taku Yasui, Kuniyasu Ikeoka, Takeshi Masaki, Keiko Yamauchi-Takihara, Mikiyasu Shirai, Issei Komuro
    • Organizer
      American Heart Association Scientific Sessions 2013
    • Place of Presentation
      Dallas Convention Center (Dallas, TX, USA)
    • Data Source
      KAKENHI-PROJECT-25670386
  • [Presentation] 視床下部歩行誘発野の刺激は麻酔下ラットの心筋組織血流量を増加させる2013

    • Author(s)
      土持裕胤、曽野部崇、稲垣薫克、白井幹康
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] マウス心臓交感神経終末におけるノルエピネフリン動態の解析-マイクロダイアリシス法を用いて-2013

    • Author(s)
      戦冬雲、杜成坤、秋山剛、曽野部崇、白井幹康
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 初期糖尿病ラットの拍動心臓で検出されたクロスブリッジ形成・解離の異常2013

    • Author(s)
      白井幹康、ジェンキンス・マシュー、曽野部崇、藤井豊、土持裕胤、吉本光佐、稲垣薫克、八木直人
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 拡張型心筋症ノックインマウスに対するグレリンの治療効果2013

    • Author(s)
      杜成坤、戦冬雲、森本幸生、秋山剛、寒川賢治、白井幹康
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 慢性低酸素により生じる右心室肥大におけるNCS-1の働き2013

    • Author(s)
      稲垣薫克、土持裕胤、西谷友重、若林繁夫、白井幹康
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] モノクロタリン肺高血圧症ラットにおける呼気水素と一酸化炭素生成の相互関連2013

    • Author(s)
      水上智恵、下内章人、野瀬和利、谷口健太郎、白井幹康
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 高血圧自然発症ラットにおける交感神経活動と動脈圧の長期連続計測とその因果関係2013

    • Author(s)
      峯山直子、吉本光佐、粟津裕子、大西佑美、島津明佳、白井幹康、三木健寿
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] α2Aアドレナリン受容体作動薬であるグアンファシンは、過度の交感神経抑制なしに心臓迷走神経活動を亢進する2013

    • Author(s)
      清水秀二、川田徹、秋山剛、神谷厚範、白井幹康、杉町勝
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 低酸素誘発性肺高血圧モデルでIL-6/Th17細胞シグナルは肺血管リモデリングに必須である2013

    • Author(s)
      片岡 崇弘、中岡 良和、曽野部 崇、保仙 直毅、稲垣 薫克、樋口 香織、有田 陽、安居 琢、池岡 邦泰、正木 豪、瀧原 圭子、白井 幹康、小室 一成
    • Organizer
      第4回Molecular Cardiovascular ConferenceII
    • Place of Presentation
      キロロリゾートホテルピアノ(北海道余市郡赤井川村)
    • Data Source
      KAKENHI-PROJECT-25670386
  • [Presentation] ダール食塩感受性ラットの高血圧発症初期における交感神経活動の変化2012

    • Author(s)
      峯山直子、吉本光佐、大西由美子、白井幹康、三木健寿
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 心虚血再灌流時の心筋間質中セロトニン動態-再取り込み・代謝の寄与-2012

    • Author(s)
      曽野部崇、秋山剛、杜成坤、戦冬雲、白井幹康
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 麻酔下マウスにおける心臓迷走神経終末からのアセチルコリン分泌モニタリング-マイクロダイアリシス法を用いて-2012

    • Author(s)
      戦冬雲、杜成坤、秋山剛、曽野部崇、白井幹康
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 意識下ラットおよびマウスにおける運動時心筋血流の直接計測2012

    • Author(s)
      土持裕胤、曽野部崇、白井幹康
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] Early diabetic diastolic dysfunction displaces myosin heads from actin in the beating heart2012

    • Author(s)
      Pearson J, Jenkins M, Edgley AJ, Sonobe T, Schwenke DO, Fujii Y, Kelly D, Yagi N, Shirai M.
    • Organizer
      24^<th> Meeting of the International Society of Hypertension
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2012-10-04
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 心筋間質5-HTとモノアミンオキシダーゼによる5-HIAAの同時モニタリング2012

    • Author(s)
      杜成坤、戦冬雲、秋山剛、曽野部崇、白井幹康
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-30
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] In vivo dynamic synchrotron imaging of coronary endothelial dysfunction in rats with early stage diabetes.2012

    • Author(s)
      Shirai M, Jenkins M, Pearson J, Sonobe T, Fujii Y, Tsuchimochi H, Yoshimoto M, Umetani K
    • Organizer
      89th Annual Meeting of the Physiological Society of Japa
    • Place of Presentation
      松本市総合体育館(長野)
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 人工灌流時の病態生理学研究のためのラット小型体外循環システムの構築2012

    • Author(s)
      藤井豊、白井幹康、稲盛修二、武輪能明、巽英介、妙中義之
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 2-kidney, 1-clip Goldblatt (2K1C)高血圧ラットモデルでの腎臓交感神経活動と動脈圧の変化2012

    • Author(s)
      吉本光佐、曽野部崇、藤井豊、三木健寿、白井幹康
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] アナフィラキシーショックによるラット門脈の血管収縮応答2012

    • Author(s)
      柳田洋、下内章人、曽野部崇、シュエンキ・ダリル、白井幹康
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 放射光微小血管造影法によるラット糖尿病冠動脈内皮障害の初期病態の検出2012

    • Author(s)
      白井幹康、ジェンキンス・マシュー、ピアソン・ジェームズ、曽野部崇、藤井豊、土持裕胤、吉本光佐、梅谷啓二
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] SPring-8放射光画像の心血管機能・再生研究への応用2012

    • Author(s)
      白井幹康
    • Organizer
      第11回日本再生医療学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-14
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 放射光X線機能画像の循環器研究への応用2011

    • Author(s)
      白井幹康
    • Organizer
      第23回北摂循環器研究会(招待講演)
    • Place of Presentation
      大阪大学(大阪)
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] Estimation of Molecular Hydrogen Consumption in the Human Whole Body after the Ingestion of Hydrogen-Rich Water2011

    • Author(s)
      Akito Shimouchi, Kazutoshi Nose, Tomoe Mizukami, Mikiyasu Shirai, Takaharu Kondo
    • Organizer
      第15回酸素ダイナミクス研究会
    • Place of Presentation
      佐賀大学(佐賀市)
    • Year and Date
      2011-09-12
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Presentation] アナフィラキシーショックに対するラット門脈の血管収縮応答2011

    • Author(s)
      柳田洋、下内章人、曽野部崇、藤井豊、芝本利重、白井幹康
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] Rho-kinase inhibition improves localised coronary dysfunction in vivo, in the diabetic microcirculation.2011

    • Author(s)
      Jenkins M, Shirai M, Edgley AJ, Kelly DJ, Pearson J, Sonobe T, Umetani K, Brown R, Schwenke DO
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      パリ(フランス)
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] モノクロタリン肺高血圧ラットでの血管内皮とRho-kinaseの機能障害は肺微小血管レベルで起こる2011

    • Author(s)
      白井幹康、シュエンキ・ダリル、曽野部崇、藤井豊、吉本光佐、下内章人、寒川賢治、梅谷啓二
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] 水素水飲水に伴う生体内水素消費量の計測2011

    • Author(s)
      下内章人,野瀬和利,水上智恵,白井幹康,近藤孝晴
    • Place of Presentation
      東邦大学医学部,東京
    • Year and Date
      2011-11-05
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Presentation] 放射光X線機能画像の循環器研究への応用2011

    • Author(s)
      白井幹康
    • Organizer
      第23回北摂循環器研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-05-10
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] 水素水飲水に伴う生体内水素消費量の計測2011

    • Author(s)
      下内章人, 野瀬和利, 水上智恵, 白井幹康, 近藤孝晴
    • Organizer
      日本安定同位体生体ガス医学応用学会
    • Place of Presentation
      東邦大学(東京)
    • Year and Date
      2011-11-05
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Presentation] Rho-kinase inhibition improves localised coronary dysfunction in vivo, in the diabetic microcirculation2011

    • Author(s)
      Jenkins M, Shirai M, Edgley AJ, Kelly DJ, Pearson J, Sonobe T, Umetani K, Brown R, Schwenke DO.
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Paris (France)
    • Year and Date
      2011-08-27
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] Specific microvascular dysfunction and Rho kinase-mediated rat pulmonary hypertension2011

    • Author(s)
      Shirai M, Schwenke D, Sonobe T, Fujii Y, Yoshimoto M, Shimouchi A, Kangawa K, Umetani K
    • Organizer
      日本生理学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Presentation] Yanagida H, Shimouchi A, Sonobe T, Fujii Y, Shibamoto T, Shirai M. Constrictive response to anaphylactic shock in rat portal veins2011

    • Author(s)
      Yanagida H, Shimouchi A, Sonobe T, Fujii Y, Shibamoto T, Shirai M
    • Organizer
      日本生理学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Presentation] グレリンノックアウトマウスでは慢性低酸素負荷で怒る換気適応が減弱する2011

    • Author(s)
      曽野部崇、シュエンキ・ダリル、徳留健、岸本一郎、寒川賢治、白井幹康
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] アンジオテンシンII慢性投与による交感神経活動と動脈圧の変化2011

    • Author(s)
      吉本光佐、三木健寿、白井幹康、Osborn John
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-28
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] マグネシウム静脈内投与の副腎交感神経節伝達に及ぼす影響2010

    • Author(s)
      秋山剛、川田徹、清水秀二、曽野部崇、杉町勝、白井幹康
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] 運動負荷に伴う呼気・皮膚ガス微量成分の動態2010

    • Author(s)
      下内章人、野瀬和利、白井幹康
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] Estimation of oxygen radical production in the human whole body by molecular hydrogen consumption after the Ingestion of hydrogen-rich water2010

    • Author(s)
      Shimouchi A, Nose K, Shirai M, Kondo T.
    • Organizer
      The International Society on O2 Transport to Tissue 2010
    • Place of Presentation
      Ascona, Switzerland
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Presentation] 心臓交感・副交感神経活動に対するα_2アゴニストの影響2010

    • Author(s)
      清水秀二、秋山剛、川田徹、神谷厚範、宍戸稔聡、白井幹康、杉町勝
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.2010

    • Author(s)
      白井幹原
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] In vivo放射光微小血管造影法によるマウス肺循環系の評価2010

    • Author(s)
      曽野部崇、シュエンキ・ダリル、ピアーソン・ジェイムズ、梅谷啓二、白井幹康
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-19
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] グレリン投与は急性心筋梗塞時の心臓交感神経活動増大と致死率を低下させる2010

    • Author(s)
      白井幹康、シュエンキ・ダリル、徳留健、岸本一郎、寒川賢治
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] Estimation of oxygen radical production in the human whole body by molecular hydrogen consumption after the Ingestion of hydrogen-rich water2010

    • Author(s)
      Shimouchi A, Nose K, Shirai M, Kondo T
    • Organizer
      The International Society on O2 Transport to Tissue
    • Place of Presentation
      Switzerland
    • Data Source
      KAKENHI-PROJECT-21659211
  • [Presentation] Dynamic synchrotron imaging of the coronary vasculature in vivo in rat models of heart failure and diabetes.2009

    • Author(s)
      Pearson J, Jenkins MJ, Okura Y, Tani D, Schwenke DO, Umetani K, Kangawa K, Shirai M
    • Organizer
      36^<th> International congress of Physiological Sciences
    • Place of Presentation
      Kyoto.
    • Year and Date
      2009-07-30
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] Contrast angiography of the rat renal microcirculation in vivo using synchrotron radiation2009

    • Author(s)
      白井幹康
    • Organizer
      第36回国際生理学会世界大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-07-29
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] Changes in pulmonary blood flow in monocrotaline and hypoxia-induced models of pulmonary hypertension, assessed using synchrotron radiation.2009

    • Author(s)
      Schwenke DO, Pearson JT, Kangawa K, Ymetani, K, Shirai M, Cragg PA.
    • Organizer
      36^<th> International congress of Physiol- ogical Sciences
    • Place of Presentation
      Kyoto.
    • Year and Date
      2009-07-29
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] The importance of interfilament spacing in the regulation of crossbridge kinetics in the in situ heart.2009

    • Author(s)
      Pearson J, Yagi N, Schwenke DO, Shirai M
    • Organizer
      36^<th> International congress of Physiological Sciences
    • Place of Presentation
      Kyoto.
    • Year and Date
      2009-07-28
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] contrast angiography of the rat renal microcirculation in vivo using synchrotron radiation.2009

    • Author(s)
      Shirai M, Eppel GG, Jacono DL, Umetani K, Evans RG, Pearson J
    • Organizer
      36^<th> Inter- national congress of Physiological Sciences
    • Place of Presentation
      Kyoto.
    • Year and Date
      2009-08-01
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] 放射光を用いた心血管機能の評価2008

    • Author(s)
      白井幹康
    • Organizer
      第152回医用画像情報学会(特別講演)
    • Place of Presentation
      広島
    • Year and Date
      2008-10-04
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] シュエンキ・ダリル、ピアーソン・ジェームズ、梅谷啓二 放射光高速微小血管造影法を用いた低酸素性肺循環応答の観察:閉胸ラットを用いて2008

    • Author(s)
      白井幹康
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] 放射光を用いた心血管機能の評価2008

    • Author(s)
      白井幹康
    • Organizer
      医用画像情報学会(特別講演)
    • Place of Presentation
      広島市
    • Year and Date
      2008-10-04
    • Data Source
      KAKENHI-PROJECT-20590242
  • [Presentation] Early diabetic diastolic dysfunction displaces myosin heads from actin the beating heart

    • Author(s)
      Pearson J, Jenkins M, Edgley AJ, Sonobe T, Schwenke DO, Fujii Y, Kelly D, Yagi N, Shirai M.
    • Organizer
      24th Meeting of the International Society of Hypertension
    • Place of Presentation
      Sydney
    • Invited
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] Hyperoxia condition promotes an inflamatory response during extracorporeal circulation in rat model

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, et al
    • Organizer
      51st Japanese Society of Artificial Organs
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-24249086
  • [Presentation] 抗Interleukin-6(IL-6)受容体抗体によるIL-6阻害療法は低酸素誘発性肺高血圧の病態形成を抑制する

    • Author(s)
      中岡良和、橋本崇弘、曽野部崇、瀧原圭子、白井幹康、小室一成
    • Organizer
      第2回日本肺循環学会学術集会
    • Place of Presentation
      東京ステーションコンファレンス(東京都千代田区)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670386
  • [Presentation] Abnormal cross-bridge dynamics in the in situ beating rat heart in early diabetes

    • Author(s)
      Shirai M, Jenkins M, Sonobe T, Fujii Y, Tsuchimochi H, Yoshimoto M, Inagaki T, Yagi N
    • Organizer
      90th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23650213
  • [Presentation] Hydrogen gas suppresses systemic inflammatory response during cardiopulmonary bypass in a rat model

    • Author(s)
      Fujii Y, Shirai M, Takewa Y, et al
    • Organizer
      American Society for Artificial Internal Organs
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-24249086
  • [Presentation] Blockade of interleukin-6 signaling might be a promising therapeutic option for pulmonary arterial hypertension via regulating Th17 cell differentiation

    • Author(s)
      Takahiro Hashimoto-Kataoka, Yoshikazu Nakaoka, Takashi Sonobe, Naoki Hosen, Yoh Arita, Taku Yasui, Kuniyasu Ikeoka, Takeshi Masaki, Tadakatsu Inagaki, Keiko Yamauchi-Takihara, Mikiyasu Shirai, Issei Komuro
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Data Source
      KAKENHI-PROJECT-25670386
  • [Presentation] Alteration of hydrogen exhalation and carbon monoxide production in monocrotaline-induced pulmonary hypertension rats

    • Author(s)
      Mizukami T, Shimouchi A, Shirai M, et al
    • Organizer
      Breath Analysis Summit
    • Place of Presentation
      Berlin
    • Data Source
      KAKENHI-PROJECT-24249086
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  • 53.  清水 希功 (40309662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 54.  山崎 登自 (20116122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 55.  藤里 俊哉 (60270732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 56.  松本 睦子 (90263706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 57.  北岸 宏亮 (60448090)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 58.  YAGI Naoto
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 59.  UMETANI Keiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 60.  TOKUDOME Takeshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 61.  ピアーソン ジェームズ
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 62.  JAMES T.Pearson
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 63.  DARYL O.Schwenke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 64.  西上 和弘
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 65.  ZHAN DONGYUN
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 66.  KAWADA Toru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 67.  KURODA Tadashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 68.  FUJII Yutaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 8 results
  • 69.  UMEKI Akihide
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 70.  NISHIYAMA Koichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 71.  KIDOYA Hiroyasu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 72.  YAMASHITA Jun
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 73.  MURAMATSU Fumitaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 74.  LI Meihua
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 75.  神谷 厚範
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 76.  杉町 勝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 77.  清水 秀二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 78.  佐田 悠輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 79.  上村 和紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 80.  細田 洋司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 81.  吉本 光佐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 82.  瀧原 圭子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 83.  武輪 能明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 84.  妙中 義之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 85.  巽 英介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 86.  TURNER MICHAEL
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 87.  藤田 敏郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 88.  小倉 彩世子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 89.  秋 利彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 90.  新谷 香
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 91.  下澤 達雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 92.  日野 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 93.  宮里 幹也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 94.  土田 邦博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 95.  中谷 直史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 96.  高倉 伸幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 97.  山岸 敬幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 98.  南 敬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 99.  栗原 由紀子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 100.  栗原 裕基
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 101.  内藤 尚道
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 102.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 103.  山川 大史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 104.  SCHWENKE Daryl O.
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 105.  岸本 一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 106.  寒川 賢治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 107.  鄭 燦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 108.  山下 静也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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