Nagao Mototsugu 長尾元嗣

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NAGAO Mototsugu 長尾元嗣

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Researcher Number	10468762
Other IDs	https://orcid.org/0000-0001-6880-5161
Affiliation (Current)	2024: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 日本医科大学, 医学部, 准教授 2019 – 2023: 日本医科大学, 医学部, 講師 2016 – 2017: 日本医科大学, 大学院医学研究科, 助教 2013 – 2016: 日本医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / 0803:Pathology, infection/immunology, and related fields / Experimental pathology Except Principal Investigator Experimental pathology / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator CD36 / 糖尿病 / Oikawa-Nagaoマウス / β細胞 / 2型糖尿病 / インスリン分泌能 / 膵β細胞 / インスリン分泌不全 / 膵ランゲルハンス島 / インスリン分泌機構 … More / ２型糖尿病 / ヒト膵ランゲルハンス島 / グルカゴン / インスリン / 肥満 / インスリンシグナル / 脂肪酸 / インスリン分泌 / ONマウス / エキソサイトーシス / 糖尿病モデルマウス / レプチン分泌能 / 摂食行動 / 耐糖能異常 / 高脂肪食 / モデルマウス / 選抜交配 … More Except Principal Investigator 糖尿病 / 動脈硬化 / モデルマウス / 耐糖能異常 / 疫学 / 高血圧 / 疫学研究 / コレステロール取込 / 高比重リポ蛋白 / 脂肪毒性 / 膵β細胞 / 脂肪酸 / インスリン分泌 / 血糖値変動 / レプチン / 実験病理学 / マウス / 肥満 / 過食 / メタボリックシンドローム Less

Impaired islet hormone secretion by CD36, a new pathophysiology of type 2 diabetes : Validation in human pancreatic isletsPrincipal Investigator
- Principal Investigator
  
  長尾元嗣
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Nippon Medical School
New pathophysiology of type 2 diabetes: Altered beta-cell CD36 expression and impaired insulin secretionPrincipal Investigator
- Principal Investigator
  
  長尾元嗣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Nippon Medical School
健常集団におけるHDL機能の分布及び動脈硬化・高血圧との関連性を検討する疫学研究
- Principal Investigator
  
  大塚俊昭
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Nippon Medical School
２型糖尿病発症における膵β細胞の脂肪適応と脂肪毒性についての栄養生理学的検証
- Principal Investigator
  
  浅井明
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Nippon Medical School
Addressing the role of CD36 in insulin secretion and diabetes incidence using a new mouse modelPrincipal Investigator
- Principal Investigator
  
  NAGAO Mototsugu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Nippon Medical School
Development of metabolic syndrome and feeding behavior: analysis in new model mice
- Principal Investigator
  
  SUGIHARA Hitoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nippon Medical School
Impaired glucose tolerance as a risk factor for arteriosclerotic disease: analysis in new model mice
- Principal Investigator
  
  ASAI Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
  Nippon Medical School
Identification of the determinants of susceptibility to high-fat diet-induced glucose intolerance using a new mouse modelPrincipal Investigator
- Principal Investigator
  
  NAGAO Mototsugu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nippon Medical School

All 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Selectively bred rodent models for studying the etiology of type 2 diabetes: Goto-Kakizaki rats and Oikawa-Nagao mice2023
- Author(s)
  Nagao Mototsugu、Asai Akira、Eliasson Lena、Oikawa Shinichi
- Journal Title
  
  Endocr J
  
  Volume: 70 Issue: 1 Pages: 19-30
- DOI
  10.1507/endocrj.EJ22-0253
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05453, KAKENHI-PROJECT-22K07008
[Journal Article] 新規糖尿病モデルOikawa-Nagaoマウスの開発と２型糖尿病・動脈硬化の病態生理研究2022
- Author(s)
  長尾元嗣
- Journal Title
  
  糖尿病合併症
  
  Volume: 26 Pages: 171-179
- Data Source
  KAKENHI-PROJECT-22K07008
[Journal Article] Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells2022
- Author(s)
  Mototsugu Nagao, Jens O. Lagerstedt, Lena Eliasson
- Journal Title
  
  Diabetology International
  
  Volume: 13 Issue: 3 Pages: 471-479
- DOI
  10.1007/s13340-022-00580-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07008
[Journal Article] Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice2020
- Author(s)
  Nagao Mototsugu、Esguerra Jonathan Lou S.、Wendt Anna、Asai Akira、Sugihara Hitoshi、Oikawa Shinichi、Eliasson Lena
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2128 Pages: 25-54
- DOI
  10.1007/978-1-0716-0385-7_3
- ISBN
  9781071603840, 9781071603857
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
[Journal Article] Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells2020
- Author(s)
  Nagao Mototsugu、Esguerra Jonathan L.S.、Asai Akira、Ofori Jones K.、Edlund Anna、Wendt Anna、Sugihara Hitoshi、Wollheim Claes B.、Oikawa Shinichi、Eliasson Lena
- Journal Title
  
  Diabetes
  
  Volume: in press Issue: 6 Pages: 1193-1205
- DOI
  10.2337/db19-0944
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
[Journal Article] Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa?Nagao Diabetes-Prone and Diabetes-Resistant mice2020
- Author(s)
  Asai Akira、Nagao Mototsugu、Hayakawa Koji、Miyazawa Teruo、Sugihara Hitoshi、Oikawa Shinichi
- Journal Title
  
  Diabetologia
  
  Volume: 63 Issue: 9 Pages: 1836-1846
- DOI
  10.1007/s00125-020-05191-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23872
[Journal Article] 脂肪摂取と2型糖尿病2015
- Author(s)
  長尾元嗣, 浅井明, 杉原仁, 及川眞一
- Journal Title
  
  オレオサイエンス
  
  Volume: 15 Pages: 69-78
- NAID
  130006329110
- Data Source
  KAKENHI-PROJECT-25860300
[Journal Article] 脂肪摂取と2型糖尿病2015
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Journal Title
  
  オレオサイエンス
  
  Volume: 15 Pages: 21-30
- NAID
  130006329110
- Data Source
  KAKENHI-PROJECT-26460497
[Journal Article] Repetitive Glucose Spikes Accelerate Atherosclerotic Lesion Formation in C57BL/6 Mice2015
- Author(s)
  Yuki Shuto, Akira Asai, Mototsugu Nagao, Hitoshi Sugihara, and Shinichi Oikawa
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 8 Pages: e0136840-e0136840
- DOI
  10.1371/journal.pone.0136840
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460497
[Journal Article] Fat intake and the development of type 2 diabetes [Review]2015
- Author(s)
  M Nagao, A Asai, H Sugihara, S Oikawa
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 7 Pages: 561-572
- DOI
  10.1507/endocrj.EJ15-0055
- NAID
  130005089858
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
[Journal Article] Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance2015
- Author(s)
  Nagao M, Asai A, Sugihara H, Oikawa S
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 4 Pages: 371-378
- DOI
  10.1507/endocrj.EJ14-0241
- NAID
  130005066937
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860300, KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
[Journal Article] 高血糖と動脈硬化実験動物からのアプローチ2014
- Author(s)
  長尾元嗣, 浅井明, 及川眞一
- Journal Title
  
  糖尿病合併症
  
  Volume: 28 Pages: 66-69
- Data Source
  KAKENHI-PROJECT-25860300
[Journal Article] Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance.2014
- Author(s)
  Nagao M, Asai A, Inaba W, Kawahara M, Shuto Y, Kobayashi S, Sanoyama D, Sugihara H, Yagihashi S, Oikawa S
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e84725-e84725
- DOI
  10.1371/journal.pone.0084725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659158, KAKENHI-PROJECT-25860300
[Journal Article] Effect of impaired glucose tolerance on atherosclerotic lesion formation: an evaluation in selectively bred mice with different susceptibilities to glucose intolerance2013
- Author(s)
  Asai A, Nagao M, Kawahara M, Shuto Y, Sugihara H, Oikawa S
- Journal Title
  
  Atherosclerosis
  
  Volume: 231 Issue: 2 Pages: 421-426
- DOI
  10.1016/j.atherosclerosis.2013.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860300
[Journal Article] メタボリックシンドロームにおける疾患感受性規定因子の解明-新規モデルマウスを用いた解析-2013
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Journal Title
  
  Therapeutic Research
  
  Volume: 34 Pages: 931-935
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] CD36 subcellular localisation in beta cells between diabetes-prone and -resistant mice: possible involvement of CD36 in beta cell dysfunction2022
- Author(s)
  Nagao Mototsugu、Asai Akira、Mikiko Okazaki-Hada、Hitoshi Sugihara、Eliasson Lena、Oikawa Shinichi
- Organizer
  58th Annual Meeting of the European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] CD36 subcellular localisation in beta cells between diabetes-prone and -resistant mice: possible involvement of CD36 in beta cell dysfunction2022
- Author(s)
  Mototsugu Nagao, Akira Asai, Mikiko Okazaki-Hada, Hitoshi Sugihara, Lena Eliasson, Shinichi Oikawa
- Organizer
  58th Annual Meeting of the European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07008
[Presentation] Oikawa-Nagao Diabetes-Prone マウスの体重増加・耐糖能悪化を規定するレプチン遺伝子の発現調節2022
- Author(s)
  羽田幹子、浅井明、長尾元嗣、及川眞一、岩部真人
- Organizer
  日本肥満学会(第43回) 日本肥満症治療学会(第40回) 学術集会
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] 新規糖尿病モデルOikawa-Nagaoマウスの開発と2型糖尿病の病態生理研究2021
- Author(s)
  長尾元嗣
- Organizer
  第94回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] 新規糖尿病モデルOikawa-Nagaoマウスの開発と2型糖尿病・動脈硬化の病態生理研究2021
- Author(s)
  長尾元嗣
- Organizer
  第36回日本糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] 新規糖尿病モデルOikawa-Nagaoマウスの開発と２型糖尿病の病態生理研究2021
- Author(s)
  長尾元嗣
- Organizer
  第94回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23872
[Presentation] Pathogenic role of beta-cell CD36 in the development of type 2 diabetes with obesity2021
- Author(s)
  長尾元嗣、浅井明、杉原仁、Claes B. Wollheim、及川眞一、 Lena Eliasson
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] Pathogenic role of beta-cell CD36 in the development of type 2 diabetes with obesity2021
- Author(s)
  長尾元嗣,、浅井明、杉原仁、Claes B. Wollheim、及川眞一、 Lena Eliasson
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23872
[Presentation] 新規糖尿病モデルOikawa-Nagaoマウスの開発と２型糖尿病・動脈硬化の病態生理研究2021
- Author(s)
  長尾元嗣
- Organizer
  第36回日本糖尿病合併症学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K23872
[Presentation] CD36によるβ細胞機能障害と糖尿病発症：Oikawa-Nagao（ON）マウスを端緒とした研究成果2020
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Organizer
  第34回日本肥満・糖尿病動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K23872
[Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加と脂肪組織におけるレプチン産生能との関係2018
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第32回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Reduced insulin secretion in a diet-induced glucose intolerance susceptible mouse model is coupled with increased CD36 and triglycerides in the β cells2017
- Author(s)
  Asai A, Nagao M, Tsuduki T, Miyazawa T, Esguerra JLS, Eliasson L, Sugihara H, Oikawa S
- Organizer
  European Association for the Study of Diabetes 53rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加：若齢期におけるレプチン動態との関係2017
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホールヴィアマーレ（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加：若齢期におけるレプチン動態との関係2017
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホールヴィアマーレ（横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 膵島におけるCD36/FATの発現と脂肪酸動態、インスリン分泌能との関係：新規耐糖能異常モデルマウスを用いた解析2017
- Author(s)
  浅井明、長尾元嗣、都築毅、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 高脂肪食投与後の糖尿病発症における過食、体重増加とレプチンとの関係：新規選抜交配モデルマウスの解析から2016
- Author(s)
  浅井明、長尾元嗣、川原百代、加藤俊治、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Antiatherogenic effect of metformin in two mouse lines with different susceptibility to glucose intolerance2016
- Author(s)
  A Asai, M Nagao, M Kawahara, T Miyazawa, H Sugihara, S Oikawa
- Organizer
  84th European Atherosclerosis Society Congress
- Place of Presentation
  Congress und Messe Innsbruck GmbH, Innsbruck, Austria
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 選抜交配による高脂肪食誘発性糖尿病モデルマウスの開発2016
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  武庫川女子大学（兵庫県西宮市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 高脂肪食投与後の糖尿病発症における過食、体重増加とレプチンとの関係：新規選抜交配モデルマウスの解析から2016
- Author(s)
  浅井明、長尾元嗣、川原百代、加藤俊治、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 選抜交配による高脂肪食誘発性糖尿病モデルマウスの開発2016
- Author(s)
  浅井明、長尾元嗣、川原百代、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  武庫川女子大学（兵庫県西宮市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Antiatherogenic effect of metformin in two mouse lines with different susceptibility to glucose intolerance2016
- Author(s)
  A Asai, M Nagao, M Kawahara, T Miyazawa, H Sugihara, S Oikawa
- Organizer
  84th European Atherosclerosis Society Congress
- Place of Presentation
  Congress und Messe Innsbruck GmbH, Innsbruck, Austria
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] 新規耐糖能異常モデルマウスにおけるメトホルミンの抗動脈硬化作用2015
- Author(s)
  周東佑樹、浅井明、長尾元嗣、杉原仁、及川眞一
- Organizer
  第23回日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  東北大学片平キャンパス北門会館（宮城県仙台市）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 選抜交配により作成した新規糖尿病モデルマウスの摂食行動に関する解析2015
- Author(s)
  長尾元嗣、浅井明、真山大輔、周東佑樹、小林俊介、杉原仁、及川眞一
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Spontaneous high fat diet overeating and body weight gain in selectively bred mice for diet-induced glucose intolerance: possible role of leptin2015
- Author(s)
  A Asai, M Nagao, H Sugihara, S Oikawa
- Organizer
  European Association for the Study of Diabetes 51st Annual Meeting
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08434
[Presentation] Metforminの抗動脈硬化作用に関する耐糖能異常マウスを用いた検討2015
- Author(s)
  周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
- Organizer
  第47回日本動脈硬化学会・学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 食後高血糖が動脈硬化巣形成に及ぼす影響～新規耐糖能異常モデルマウスを用いた解析～2015
- Author(s)
  浅井明、周東佑樹、長尾元嗣、杉原仁、宮澤陽夫、及川眞一
- Organizer
  日本栄養・食糧学会東北支部（第49回）北海道支部（第45回）合同支部大会
- Place of Presentation
  東北大学農学部（宮城県仙台市）
- Year and Date
  2015-11-24
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 高脂肪食誘導性耐糖能異常への感受性が異なる新規選抜交配モデルマウスにおける動脈硬化巣形成に関する解析2014
- Author(s)
  周東佑樹、浅井明、長尾元嗣、杉原仁、及川眞一
- Organizer
  第28回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] Gene-Environment Interactionに基づいた新しい糖尿病モデルマウスの開発とその解析2014
- Author(s)
  長尾元嗣
- Organizer
  第82回日本医科大学医学会総会
- Place of Presentation
  東京
- Year and Date
  2014-09-06
- Invited
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食誘導性耐糖能異常への感受性が異なる新規選抜交配モデルマウスのインスリン分泌能に関する解析2014
- Author(s)
  長尾元嗣、浅井明、周東佑樹、杉原仁、及川眞一
- Organizer
  第28回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高血糖と動脈硬化－実験動物からのアプローチ－2013
- Author(s)
  長尾元嗣、浅井明、杉原仁、鈴木信也、永島和幸、及川眞一
- Organizer
  第28回日本糖尿病合併症学会
- Place of Presentation
  旭川
- Invited
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食誘発性耐糖能異常に対する感受性の異なる２系統の選抜交配マウスにおける耐糖能・体重・摂餌量の世代間比較2013
- Author(s)
  長尾元嗣、浅井明、周東佑樹、川原百代、小林俊介、真山大輔、杉原仁、及川眞一
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] Impaired islet function and structure in mice with hereditary predisposition to high fat diet-induced glucose intolerance2013
- Author(s)
  Nagao M, Asai A, Inaba W, Kawahara M, Sugihara H, Yagihashi S, Oikawa S
- Organizer
  49th EASD Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食に対する耐糖能異常の感受性が異なる新規選抜交配モデルマウスの単離膵島に関する解析2013
- Author(s)
  長尾元嗣、浅井明、川原百代、小林俊介、真山大輔、周東佑樹、原田太郎、稲垣恭子、杉原仁、及川眞一
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] Feeding behavior as a hereditary predisposition to diet-induced glucose intolerance2013
- Author(s)
  Nagao M, Asai A, Kobayashi S, Shuto Y, Sanoyama D, Harada T, Tanimura-Inagaki K, Sugihara H, Oikawa S
- Organizer
  36th Naito Conference
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] Feeding behavior in mice with hereditary predisposition to high fat-diet induced glucose intolerance2013
- Author(s)
  Nagao M, Asai A, Kobayashi S, Shuto Y, Sanoyama D, Sugihara H, Oikawa S
- Organizer
  Asia-Pacific Diabetes and Obesity Study Group symposium 2013
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] Repetitive selective breeding for susceptibility to glucose intolerance accelerates atherosclerotic lesion formation in mice2013
- Author(s)
  Asai A, Nagao M, Kawahara M, Sugihara H, Oikawa S
- Organizer
  49th EASD Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食による体重増加や耐糖能異常の発症を規定する遺伝的要因の解析：マウスを用いた長期選抜交配からの考察2013
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食誘発性耐糖能異常への感受性が異なる2系統のマウスにおける摂食行動の検討2013
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Organizer
  第40回日本神経内分泌学会学術集会
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食に対する耐糖能異常の感受性を規定する遺伝的要因の考察：マウスを用いた長期選抜交配から2013
- Author(s)
  小林俊介、長尾元嗣、浅井明、川原百代、真山大輔、周東佑樹、原田太郎、稲垣恭子、杉原仁、及川眞一
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食誘発性耐糖能異常に対する感受性の異なる2系統の選抜交配マウスにおける動脈硬化巣形成の選抜交配世代間比較2013
- Author(s)
  周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食誘導性耐糖異常への感受性が異なるSDG-P/Rマウスのインスリン分泌能と膵臓遺伝子発現に関する解析
- Author(s)
  長尾元嗣、浅井明、真山大輔、周東佑樹、小林俊介、杉原仁、及川眞一
- Organizer
  第46回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食誘発生耐糖能異常への感受性が異なる２系統のマウスにおけるレプチン分泌と視床下部レプチン受容体に関する解析
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Organizer
  第41回日本神経内分泌学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 高脂肪食誘発生肥満耐糖能異常マウスと同抵抗性マウスのレプチン分泌動態に関する解析
- Author(s)
  長尾元嗣、浅井明、小林俊介、周東佑樹、真山大輔、杉原仁、及川眞一
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] 耐糖能と摂食行動の遺伝的な差異が寿命に及ぼす影響：新規選抜交配モデルマウスでの解析
- Author(s)
  真山大輔、長尾元嗣、浅井明、周東佑樹、小林俊介、杉原仁、及川眞一
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] Transgenerational phenotypic changes in selectively bred mice for different susceptibilities to diet-induced glucose intolerance
- Author(s)
  Nagao M, Asai A, Sugihara H, Oikawa S
- Organizer
  50th EASD (Annual Meeting of the European Association for the Study of Diabetes)
- Place of Presentation
  Vienna, Austria
- Year and Date
  2014-09-15 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25860300
[Presentation] Twice-daily hyperglycaemic spikes accelerate atherosclerotic lesion formation in C57BL/6 mice
- Author(s)
  Y. Shuto, A. Asai, M. Nagao, M. Kalahari, H. Sugihara, S. Oikawa
- Organizer
  50th EASD Annual Meeting
- Place of Presentation
  Vienna, Austria
- Year and Date
  2014-09-15 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 血糖変動が動脈硬化巣形成に及ぼす影響：マウスを用いた生体レベルでの解析
- Author(s)
  周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
- Organizer
  第46回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 遺伝的な膵島機能によって規定される高脂肪食誘導性耐糖能異常の出現：新規選抜交配モデルマウスでの解析
- Author(s)
  長尾元嗣、浅井明、稲葉渉、小林俊介、周東佑樹、真山大輔、杉原仁、八木橋操六、及川眞一
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25860300

1. ASAI Akira (30500011)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. SUGIHARA Hitoshi (60183414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. NAKAGAWA Kiyotaka (80361145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大塚俊昭 (80339374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 川田智之 (00224791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小谷英太郎 (10287708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 加藤活人 (40409157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAGIHASHI Souroku

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. INABA Wataru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Nagao Mototsugu 長尾 元嗣

NAGAO Mototsugu 長尾 元嗣

Research Projects

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Co-Researchers

Impaired islet hormone secretion by CD36, a new pathophysiology of type 2 diabetes : Validation in human pancreatic isletsPrincipal Investigator

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New pathophysiology of type 2 diabetes: Altered beta-cell CD36 expression and impaired insulin secretionPrincipal Investigator

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健常集団におけるHDL機能の分布及び動脈硬化・高血圧との関連性を検討する疫学研究

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２型糖尿病発症における膵β細胞の脂肪適応と脂肪毒性についての栄養生理学的検証

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Addressing the role of CD36 in insulin secretion and diabetes incidence using a new mouse modelPrincipal Investigator

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Development of metabolic syndrome and feeding behavior: analysis in new model mice

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Impaired glucose tolerance as a risk factor for arteriosclerotic disease: analysis in new model mice

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Identification of the determinants of susceptibility to high-fat diet-induced glucose intolerance using a new mouse modelPrincipal Investigator

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[Journal Article] Selectively bred rodent models for studying the etiology of type 2 diabetes: Goto-Kakizaki rats and Oikawa-Nagao mice2023

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[Journal Article] 新規糖尿病モデルOikawa-Nagaoマウスの開発と２型糖尿病・動脈硬化の病態生理研究2022

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[Journal Article] Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells2022

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[Journal Article] Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice2020

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[Journal Article] Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells2020

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Nagao Mototsugu 長尾元嗣

NAGAO Mototsugu 長尾元嗣

[Journal Article] 高血糖と動脈硬化実験動物からのアプローチ2014