Yurube Takashi 由留部崇

… Alternative Names

YURUBE Takashi 由留部崇

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Researcher Number	10514648
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 神戸大学, 医学部附属病院, 助教 2017 – 2020: 神戸大学, 医学部附属病院, 特定助教 2017: 神戸大学, 医学部附属病院, 助教 2015 – 2017: 神戸大学, 医学部附属病院, その他 2014 – 2016: 神戸大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 56020:Orthopedics-related / Medical systems / Orthopaedic surgery
Keywords	Principal Investigator 整形外科 / 脊椎 / 椎間板変性 / mTOR / オートファジー / CRISPR-Cas9 / RNA干渉 / 遺伝子治療 / 脊椎椎間板変性 / 椎間板 / LASCol / 椎間板ヘルニア / 老化 … More Except Principal Investigator … More 椎間板変性 / 椎間板 / 抗炎症 / 抗炎症作用 / アディポロン / アディポネクチン / オートファジー / Raptor / AdipoRon / 脊椎 / 穿刺モデル / mTORC / 変形性膝関節症 / テムシロリムス / 変形性関節症 / 骨転移動物モデル / GCIB / 骨転移 / 脊椎インプラント / 徐放化抗がん剤 / 非金属脊椎インプラント / 徐放化抗癌剤 / 脊椎転移 / RNA干渉 / mTOR経路 / 免疫特権 / 椎間板ヘルニア / 腰部脊柱管狭窄症 / 棘突起間スペーサー / 低侵襲脊椎手術 / 低侵襲手術システム / 固定術 / 脊椎疾患 / 低侵襲治療 / 動物モデル / 腰部脊柱管狭窄 / 遺伝子治療 / 腰痛 / Rictor / mTORC1阻害薬 / セネッセンス / アポトーシス / siRNA / mTOR Less

Development of gene therapy for intervertebral disc degeneration by using cationized gelatin nanospheresPrincipal Investigator
- Principal Investigator
  
  由留部崇
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kobe University
アディポネクチンによる椎間板変性・炎症に対する治療法の開発
- Principal Investigator
  
  張鍾穎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kobe University
Development of gene and pharmacological therapies for intervertebral disc degeneration by modulating mTORC1Principal Investigator
- Principal Investigator
  
  YURUBE Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kobe University
the study of new treatment for spinal metastasis with the combination of sustained release anti-cancer drug and non-metal spinal instrumentation
- Principal Investigator
  
  Kakutani Kenichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kobe University
Development of a new treatment against intervertebral disc degeneration and inflammation using adiponectin
- Principal Investigator
  
  Zhang Zhongying
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kobe University
Development of new therapeutic drugs for osteoarthritis targeting mTORC1
- Principal Investigator
  
  Matsushita Takehiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kobe University
Regeneration of the intervertebral disc in the spine by Low Adhesive Scaffold Collagen (LASCol)Principal Investigator
- Principal Investigator
  
  YURUBE Takashi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kobe University
Development of treatment strategies for intervertebral disc degeneration by modulating mTOR signalingPrincipal Investigator
- Principal Investigator
  
  YURUBE Takashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
The approach of molecular treatments for the intervertebral disc degeneration.
- Principal Investigator
  
  Maeno Koichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University
Elucidation of pathogenesis of low back pain related to degeneration of intervertebral disc and development of minimally invasive treatment system
- Principal Investigator
  
  Nishida Kotaro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical systems
- Research Institution
  Kobe University
Development of treatment strategies for intervertebral disc degeneration by modulating autophagyPrincipal Investigator
- Principal Investigator
  
  YURUBE Takashi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kobe University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Patent

[Journal Article] Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting <scp>mTORC1</scp> and inducing autophagy through Akt activation2024
- Author(s)
  Yurube Takashi、Buchser William J.、Zhang Zhongying、Silwal Prashanta、Lotze Michael T.、Kang James D.、Sowa Gwendolyn A.、Vo Nam V.
- Journal Title
  
  JOR SPINE
  
  Volume: 7 Issue: 1
- DOI
  10.1002/jsp2.1303
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Anti-Inflammatory Effects of Adiponectin Receptor Agonist AdipoRon against Intervertebral Disc Degeneration2023
- Author(s)
  Ohnishi Hiroki、Zhang Zhongying、Yurube Takashi、Takeoka Yoshiki、Kanda Yutaro、Tsujimoto Ryu、Miyazaki Kunihiko、Matsuo Tomoya、Ryu Masao、Kumagai Naotoshi、Kuroshima Kohei、Hiranaka Yoshiaki、Kuroda Ryosuke、Kakutani Kenichiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 10 Pages: 8566-8566
- DOI
  10.3390/ijms24108566
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Concepts of Regeneration for Spinal Diseases in 20232023
- Author(s)
  Yurube Takashi、Han Inbo、Sakai Daisuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 22 Pages: 16335-16335
- DOI
  10.3390/ijms242216335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Intervertebral disc cell fate during aging and degeneration: apoptosis, senescence, and autophagy2023
- Author(s)
  Yurube Takashi、Takeoka Yoshiki、Kanda Yutaro、Kuroda Ryosuke、Kakutani Kenichiro
- Journal Title
  
  North American Spine Society Journal (NASSJ)
  
  Volume: 14 Pages: 100210-100210
- DOI
  10.1016/j.xnsj.2023.100210
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] 特集椎間板の基礎と臨床椎間板変性とオートファジー2023
- Author(s)
  由留部崇、武岡由樹、神田裕太郎、伊藤雅明、垣内裕司、辻本龍、黒田良祐、角谷賢一朗
- Journal Title
  
  脊椎脊髄ジャーナル
  
  Volume: 36 Issue: 1 Pages: 13-18
- DOI
  10.11477/mf.5002202004
- ISSN
  0914-4412
- Year and Date
  2023-04-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Cytokine Inhibitors Upregulate Extracellular Matrix Anabolism of Human Intervertebral Discs under Alginate Beads and Alginate-Embedded Explant Cultures2023
- Author(s)
  Kakutani Kenichiro、Yurube Takashi、An Howard S.、Doita Minoru、Masuda Koichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 15 Pages: 12336-12336
- DOI
  10.3390/ijms241512336
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Involvement of autophagy in the maintenance of rat intervertebral disc homeostasis: an in-vitro and in-vivo RNA interference study of Atg52022
- Author(s)
  Tsujimoto R.、Yurube T.、Takeoka Y.、Kanda Y.、Miyazaki K.、Ohnishi H.、Kakiuchi Y.、Miyazaki S.、Zhang Z.、Takada T.、Kuroda R.、Kakutani K.
- Journal Title
  
  Osteoarthritis and Cartilage
  
  Volume: 30 Issue: 3 Pages: 481-493
- DOI
  10.1016/j.joca.2021.12.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Protective Effects of Growth Differentiation Factor-6 on the Intervertebral Disc: An In Vitro and In Vivo Study2022
- Author(s)
  Miyazaki Kunihiko、Miyazaki Shingo、Yurube Takashi、Takeoka Yoshiki、Kanda Yutaro、Zhang Zhongying、Kakiuchi Yuji、Tsujimoto Ryu、Ohnishi Hiroki、Matsuo Tomoya、Ryu Masao、Kuroda Ryosuke、Kakutani Kenichiro
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 7 Pages: 1174-1174
- DOI
  10.3390/cells11071174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18464, KAKENHI-PROJECT-21K09323
[Journal Article] Concepts of Regeneration for Spinal Diseases in 20222022
- Author(s)
  Yurube Takashi、Han Inbo、Sakai Daisuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 17 Pages: 9710-9710
- DOI
  10.3390/ijms23179710
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Involvement of Atg5-dependent autophagy in the maintenance of rat intervertebral disc homeostasis: <i>in-vitro</i> and <i>in-vivo</i> study2021
- Author(s)
  武岡由樹、由留部崇、辻本龍、神田裕太郎、黒田良祐、角谷賢一朗
- Journal Title
  
  The Central Japan Journal of Orthopaedic Surgery & Traumatology
  
  Volume: 64 Issue: 5 Pages: 615-616
- DOI
  10.11359/chubu.2021.615
- NAID
  130008140958
- ISSN
  0008-9443, 1349-0885
- Year and Date
  2021-09-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Concepts of Regeneration for Spinal Diseases in 20212021
- Author(s)
  Yurube Takashi、Han Inbo、Sakai Daisuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8356-8356
- DOI
  10.3390/ijms22168356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Involvement of Autophagy in Rat Tail Static Compression-Induced Intervertebral Disc Degeneration and Notochordal Cell Disappearance2021
- Author(s)
  Yurube Takashi、Hirata Hiroaki、Ito Masaaki、Terashima Yoshiki、Kakiuchi Yuji、Kuroda Ryosuke、Kakutani Kenichiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 11 Pages: 5648-5648
- DOI
  10.3390/ijms22115648
- NAID
  120007097070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the <scp>ORS</scp> spine section2021
- Author(s)
  Gullbrand Sarah E.、Ashinsky Beth G.、Lai Alon、Gansau Jennifer、Crowley James、Cunha Carla、Engiles Julie B.、Fusellier Marion、Muehleman Carol、Pelletier Matthew、Presciutti Steven、Schol Jordy、Takeoka Yoshiki、Yurube Takashi、Zhang Yejia、Masuda Koichi、Iatridis James C.
- Journal Title
  
  JOR SPINE
  
  Volume: 4 Issue: 2
- DOI
  10.1002/jsp2.1147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Inhibition of Autophagy at Different Stages by ATG5 Knockdown and Chloroquine Supplementation Enhances Consistent Human Disc Cellular Apoptosis and Senescence Induction rather than Extracellular Matrix Catabolism2021
- Author(s)
  Ito Masaaki、Yurube Takashi、Kanda Yutaro、Kakiuchi Yuji、Takeoka Yoshiki、Takada Toru、Kuroda Ryosuke、Kakutani Kenichiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 8 Pages: 3965-3965
- DOI
  10.3390/ijms22083965
- NAID
  120007032328
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the <scp>ORS</scp> spine section2021
- Author(s)
  Lai Alon、Gansau Jennifer、Gullbrand Sarah E.、Crowley James、Cunha Carla、Dudli Stefan、Engiles Julie B.、Fusellier Marion、Goncalves Raquel M.、Nakashima Daisuke、Okewunmi Jeffrey、Pelletier Matthew、Presciutti Steven M.、Schol Jordy、Takeoka Yoshiki、Yang Sidong、Yurube Takashi、Zhang Yejia、Iatridis James C.
- Journal Title
  
  JOR SPINE
  
  Volume: 4 Issue: 2
- DOI
  10.1002/jsp2.1150
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Journal Article] Reduced nucleotomy-induced intervertebral disc disruption through T spontaneous spheroid formation by the Low Adhesive Scaffold Collagen (LASCol)2020
- Author(s)
  Yoshiki Takeoka, Takashi Yurube, Koichi Morimoto, Saori Kunii, Yutaro Kanda, Ryu Tsujimoto, Yohei Kawakasa Fukase, Toshiyuki Takemori, Kaoru Omae, Yuji Kakiuchi, Shingo Miyazaki, Kenichiro Kakutani, Toru Takada, Kotaro Nishidaa, Masanori Fukushimac, Ryosuke Kurodami, Naom
- Journal Title
  
  Biomaterials
  
  Volume: 235 Pages: 119781-119781
- DOI
  10.1016/j.biomaterials.2020.119781
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01398, KAKENHI-PROJECT-18K16659
[Journal Article] Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.2019
- Author(s)
  Kakiuchi Y, Yurube T, Kakutani K, Takada T, Ito M, Takeoka Y, Kanda Y, Miyazaki S, Kuroda R, Nishida K.
- Journal Title
  
  Osteoarthritis Cartilage
  
  Volume: Epubahead of print Issue: 6 Pages: 1-19
- DOI
  10.1016/j.joca.2019.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03033
[Journal Article] オートファジーと椎間板変性2018
- Author(s)
  由留部　崇、伊藤雅明、角谷賢一郎、高田　徹、黒田良祐、西田康太郎
- Journal Title
  
  別冊　BIO Clinica
  
  Volume: 7 Pages: 20-23
- Data Source
  KAKENHI-PROJECT-15H03033
[Journal Article] 脊椎椎間板髄核におけるオートファジーの重要性とその誘導による椎間板変性予防の可能性2017
- Author(s)
  由留部崇、伊藤雅明、角谷賢一朗、前野耕一郎、黒田良祐、西田康太郎
- Journal Title
  
  中部日本整形外科災害外科学会雑誌
  
  Volume: 60(3) Pages: 547-548
- NAID
  130006108244
- Data Source
  KAKENHI-PROJECT-16K20051
[Journal Article] 椎間板では他の筋骨格系組織よりもオートファジーの関与が大きく、その活性は変性とともに減少する2017
- Author(s)
  由留部崇、平田裕亮、伊藤雅明、垣内裕司、寺嶋良樹、武岡由樹、角谷賢一朗、前野耕一郎、高田徹、黒田良佑、西田康太郎
- Journal Title
  
  Journal of Spine Research
  
  Volume: 8 Pages: 106-111
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K20051
[Journal Article] Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Miyazaki S, Kuroda R, Nishida K.
- Journal Title
  
  Osteoarthritis Cartilage
  
  Volume: 25 Issue: 12 Pages: 2134-2146
- DOI
  10.1016/j.joca.2017.08.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03033, KAKENHI-PROJECT-15K10406, KAKENHI-PROJECT-16K20051
[Journal Article] 椎間板の微小環境－細胞代謝、オートファジーの観点から2017
- Author(s)
  由留部崇、伊藤雅明、角谷賢一朗、前野耕一郎、黒田良佑、西田康太郎
- Journal Title
  
  整形・災害外科
  
  Volume: 60 Pages: 279-285
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K20051
[Patent] 椎間板変性の治療剤および椎間板細胞培養剤2018
- Inventor(s)
  由留部　崇、武岡　由樹、森本　康一、國井　沙織、尾前　薫
- Industrial Property Rights Holder
  由留部　崇、武岡　由樹、森本　康一、國井　沙織、尾前　薫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-015541
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K16659
[Presentation] Selective RNA interference of Raptor/mTORC1 protects against the progression of intervertebral disc degeneration in a rat tail temporary static compression model2024
- Author(s)
  Kumagai N.、Yurube T.、Ryu M.、Takeoka Y.、Kanda Y.、Tsujimoto T.、Miyazaki K.、Ohnishi H.、Matsuo T.、Kuroshima K.、Hiranaka Y.、Kuroda R.、Kakutani K.
- Organizer
  The 70th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Comparative study between gene silencing strategies for intervertebral disc degeneration using RNA interference and CRISPR-Cas9 through the selective interference of mTOR signaling2024
- Author(s)
  Ryu M.、Yurube T.、Kumagai N.、Takeoka Y.、Kanda Y.、Tsujimoto T.、Miyazaki K.、Ohnishi H.、Matsuo T.、Kuroshima K.、Hiranaka Y.、Kuroda R.、Kakutani K.
- Organizer
  The 70th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] RNA干渉法とCRISPR-Cas9システムを用いたmTORシグナル経路の選択的阻害がもたらすヒト椎間板変性抑止効果の比較2023
- Author(s)
  劉正夫、由留部崇、武岡由樹、宮崎邦彦、大西洋輝、松尾智哉、熊谷直利、黒島康平、平中良明、黒田良祐、角谷賢一朗
- Organizer
  第38回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] CRISPR-Cas9システムとRNA干渉法を用いたmTORシグナル経路の選択的阻害による脊椎椎間板変性治療効果の比較2023
- Author(s)
  由留部崇、劉正夫、辻本龍、武岡由樹、神田裕太郎、宮崎邦彦、大西洋輝、松尾智哉、熊谷直利、黒島康平、平中良明、黒田良祐、角谷賢一朗
- Organizer
  第35回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Selective interference of Raptor/mTORC1 protects against the progression of intervertebral disc degeneration through autophagy induction in a rat tail temporary static compression model2023
- Author(s)
  Kumagai N.、Yurube T.、Ryu M.、Zhang Z.、Takeoka Y.、Kanda Y.、Miyazaki K.、Ohnishi H.、Matsuo T.、Kuroshima K.、Hiranaka Y.、Kuroda R.、Kakutani K.
- Organizer
  The 49th Annual Meeting, International Society for the Study of the Lumbar Spine (Spineweek 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Development of gene therapy by modulating intracellular mTOR signaling and autophagy for degenerative disc disease2023
- Author(s)
  Yurube T.
- Organizer
  The 3rd Annual Conference, Korean Society of Basic Neurosurgical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] CRISPR-Cas9システムを用いたmTORシグナル経路の選択的阻害による椎間板変性への新規治療法の開発2023
- Author(s)
  劉正夫、由留部崇、張鍾穎、武岡由樹、神田裕太郎、宮崎邦彦、大西洋輝、松尾智哉、熊谷直利、黒島康平、平中良明、黒田良祐、角谷賢一朗
- Organizer
  第52回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] 脊椎椎間板の恒常性維持を目指した変性予防・組織修復の試み～基礎研究から学ぶ困難の対処法～2023
- Author(s)
  由留部崇
- Organizer
  第19回名古屋脊椎脊髄Webセミナー2023
- Invited
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Development of treatment for intervertebral disc degeneration by the selective interference of the mTOR signaling pathway using the CRISPR-Cas9 system2023
- Author(s)
  Ryu M.、Yurube T.、Zhang Z.、Takeoka Y.、Kanda Y.、Miyazaki K.、Ohnishi H.、Matsuo T.、Kumagai N.、Kuroshima K.、Hiranaka Y.、Kuroda R.、Kakutani K.
- Organizer
  The 49th Annual Meeting, International Society for the Study of the Lumbar Spine (Spineweek 2023)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] ｍTORシグナル経路への選択的なRNA干渉はラット尾椎椎間板組織において変性抑止効果を有する2023
- Author(s)
  熊谷直利、由留部崇、劉正夫、辻本武尊、武岡由樹、宮﨑邦彦、大西洋輝、松尾智哉、黒島康平、平中良明、黒田良祐、角谷賢一朗
- Organizer
  第38回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] 脊椎椎間板の恒常性維持を目指した変性予防・組織修復の試み2023
- Author(s)
  由留部崇
- Organizer
  第62回大阪脊椎外科フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Selective RNA interference of the mTOR signaling pathway protects against the progression of intervertebral disc degeneration through autophagy induction in a rat tail temporary static compression model2023
- Author(s)
  Kumagai N.、Yurube T.、Ryu M.、Tsujimoto T.、Takeoka Y.、Kanda Y.、Miyazaki K.、Ohnishi H.、Matsuo T.、Kuroshima K.、Hiranaka Y.、Kuroda R.、Kakutani K.
- Organizer
  The 4th Meeting, BioSpine Japan
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] ラット尾椎椎間板におけるRaptor/mTORC1への選択的なRNA遺伝子干渉はオートファジーを誘導するとともに椎間板変性進行に対して抑制的に作用する2023
- Author(s)
  熊谷直利、由留部崇、劉正夫、張鍾穎、武岡由樹、神田裕太郎、宮﨑邦彦、大西洋輝、松尾智哉、黒島康平、平中良明、黒田良祐、角谷賢一朗
- Organizer
  第52回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] ラット椎間板恒常性維持へのオートファジーの関与：Atg5に対するRNA干渉を用いた細胞・動物実験による検討2023
- Author(s)
  辻本龍、由留部崇、武岡由樹、神田裕太郎、宮崎邦彦、大西洋輝、垣内裕司、宮崎真吾、張鍾穎、黒田良祐、角谷賢一朗
- Organizer
  第35回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] The efficacy of Adiponectin receptor agonist AdipoRon against intervertebral disc degeneration on rat tail puncture model2023
- Author(s)
  Ohnishi H, Zhang Z, Hiranaka Y, Kuroshima K, Kumagai N, Ryu M, Matsuo T, Miyazaki K, Takeoka Y, Yurube T, Kuroda R, Kakutani K
- Organizer
  69th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] Development of treatment for degenerative disc disease by the selective gene silencing of mTOR signaling using the RNA interference and CRISPR-Cas9 systems2023
- Author(s)
  Ryu M.、Yurube T.、Zhang Z.、Takeoka Y.、Kanda Y.、Miyazaki K.、Ohnishi H.、Matsuo T.、Kumagai N.、Kuroshima K.、Hiranaka Y.、Kuroda R.、Kakutani K.
- Organizer
  The 69th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Development of treatment for intervertebral disc degeneration by selective interference of the mTOR signaling pathway using the CRISPR-Cas9 system2022
- Author(s)
  Ryu M.、Yurube T.、Zhang Z.、Takeoka Y.、Kanda Y.、Miyazaki K.、Ohnishi H.、Matsuo T.、Kumagai N.、Kuroshima K.、Hiranaka Y.、Kuroda R.、Kakutani K.
- Organizer
  第3回BioSpine Japan研究会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] アディポネクチン受容体アゴニストAdipoRonの椎間板細胞へ与える影響に関する研究2022
- Author(s)
  大西洋輝,張鍾穎, 由留部崇, 武岡由樹, 宮崎邦彦,松尾智哉,劉正夫,熊谷直利,黒島康平,平中良明,黒田良祐,角谷賢一朗
- Organizer
  第37回日本整形外科学会基礎学術総会
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] Effects Of Adiponectin Receptor Agonist Adiporon On Human Intervertebral Disc Cell In A Three-Dimensional Cell Culture System And Rat Tail Puncture Model2022
- Author(s)
  Ohnishi, H , Zhang, Z , Ryu, M , Matsuo, T , Miyazaki, K , Tsujimoto, R , Kanda, Y , Kakiuchi, Y , Yurube, T , Takada, T , Kuroda, R , Kakutani, K
- Organizer
  68th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] Protective roles of Atg5-dependent autophagy against human and rat disc cellular apoptosis and senescence: an in-vitro and in-vivo loss-of-function study2022
- Author(s)
  Takeoka Y.、Kanda Y.、Yurube T.、Ito M.、Tsujimoto R.、Kakiuchi Y.、Miyazaki K.、Ohnishi H.、Matsuo T.、Ryu M.、Zhang Z.、Kuroda R.、Kakutani K.
- Organizer
  The 48th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] 椎間板再生の基礎と臨床（未来）2022
- Author(s)
  由留部崇、武岡由樹、神田裕太郎、垣内裕司、辻本龍、伊藤雅明、平田裕亮、張鍾穎、黒田良祐、角谷賢一朗
- Organizer
  第95回日本整形外科学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] 椎間板恒常性維持を目指した変性予防・組織修復の試み2022
- Author(s)
  由留部崇、武岡由樹、神田裕太郎、辻本龍、垣内裕司、伊藤雅明、平田裕亮、張鍾穎、黒田良祐、角谷賢一朗
- Organizer
  第37回日本整形外科学会基礎学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] アディポネクチン受容体アゴニストAdipoRonの椎間板細胞へ与える影響に関する研究2022
- Author(s)
  大西洋輝；張鍾穎；由留部崇；武岡由樹 ; 垣内裕司；辻本龍；宮崎邦彦；松尾智哉；劉正夫；黒田良祐；角谷賢一朗
- Organizer
  第51回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] GCIB照射がPEEK製椎弓根スクリューの引き抜き強度に与える影響2022
- Author(s)
  角谷賢一朗　豊田紀章　長宗高樹　由留部崇　張鍾穎　垣内裕司　武岡由樹　神田裕太郎　辻本龍　宮崎邦彦　宮崎真吾　高田徹　土井田稔　黒田良祐
- Organizer
  脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-20K09505
[Presentation] Effect of Adiponectin receptor agonist AdipoRon on human intervertebral disc cell in a three-dimensional cell culture and rat tail puncture model2022
- Author(s)
  Ohnishi H, Zhang Z, Ryu M, Matsuo T, Miyazaki K, Takeoka Y, Kakiuchi Y, Yurube T, Kuroda R, Kakutani K
- Organizer
  48th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] Protective roles of Atg5-dependent autophagy against human and rat disc cellular apoptosis and senescence: an in-vitro and in-vivo loss-of-function study2022
- Author(s)
  Yurube T.、Ito M.、Tsujimoto R.、Takeoka Y.、Kanda Y.、Kakiuchi Y.、Miyazaki K.、Ohnishi H.、Matsuo T.、Ryu M.、Zhang Z.、Kuroda R.、Kakutani K.
- Organizer
  The 48th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] 三次元細胞培養を用いたアディポネクチン受容体アゴニストAdipoRon投与に対するヒト椎間板細胞へ与える影響の検討2021
- Author(s)
  大西洋輝；張鍾穎；由留部崇；垣内裕司；神田裕太郎；辻本龍；宮崎邦彦；高田徹；土井田稔；黒田良祐；角谷賢一朗
- Organizer
  第36回日本整形外科学会基礎学術総会
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] ラット椎間板恒常性維持に対するAtg5依存性オートファジーの関与：ラット細胞・動物実験の検討2021
- Author(s)
  武岡由樹、由留部崇、辻本龍、神田裕太郎、黒田良祐、角谷賢一朗
- Organizer
  第136回中部日本整形外科災害外科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Effect of Adiponectin receptor agonist AdipoRon on human intervertebral disc cell in a three-dimensional cell culture2021
- Author(s)
  Ohnishi H; Zhang Z; Miyazaki；K; Tsujimoto；R; Kanda；Y; Kakiuchi；Y; Yamamoto J; Yurube；T; Takada；T; Kuroda；R; Kakutani；K
- Organizer
  47th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] Involvement of autophagy in human lumbar spine herniated and degenerative disc diseases2021
- Author(s)
  Yurube T.、Kakiuchi Y.、Ito M.、Tsujimoto R.、Kanda Y.、Miyazaki K.、Ohnishi H.、Takeoka Y.、Miyazaki S.、Yamamoto J.、Zhang Z.、Takada T.、Tadokoro K.、Kuroda R.、 Kakutani K.
- Organizer
  The 47th Virtual Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] Effect of Adiponectin receptor agonist AdipoRon on human intervertebral disc cell in a three-dimensional cell culture2021
- Author(s)
  Hiroki Ohnishi, Zhongying Zhang, Takashi Yurube, Yuji Kakiuchi,Junya Yamamoto, Yutaro Kanda, Ryu Tsujimoto, Kunihiko Miyazaki, Toru Takada, Ryosuke Kuroda, Kenichiro Kakutani
- Organizer
  The 67th, Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] In-vitro and in-vivo maintenance of rat intervertebral disc homeostasis through Atg5-dependent autophagy2021
- Author(s)
  Tsujimoto R.、Yurube T.、Takeoka Y.、Kanda Y.、Miyazaki K.、Ohnishi H.、Kakiuchi Y.、Yamamot J.、Zhang Z.、Takada T.、Kuroda R.、Kakutani K.
- Organizer
  The 47th Virtual Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09323
[Presentation] 三次元細胞培養を用いたアディポネクチン受容体アゴニストAdipoRon投与に対するヒト椎間板細胞へ与える影響の検討2021
- Author(s)
  大西洋輝；張鍾穎；宮﨑邦彦；辻本龍；神田裕太郎；垣内裕司；山本潤哉；由留部崇；髙田徹；黒田良祐；角谷賢一朗
- Organizer
  第50回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09480
[Presentation] Regenerative potential of the damaged intervertebral disc by the Low Adhesive Scaffold Collagen (LASCol)2019
- Author(s)
  Takeoka Y, Yurube T, Kunii S, Morimoto K, Fukase N, Takemori T, Kakiuchi Y, Kanda Y, Tsujimoto R, Kakutani K, Takada T, Kuroda R, Nishida K
- Organizer
  The 65th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16659
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor to protect human disc cells depending on Akt and autophagy induction2018
- Author(s)
  Yuji Kakiuchi+, Takashi Yurube*, Yoshiki Takeoka+, Masaaki Ito+, Yutaro Kanda+, Kenichiro Kakutani*, Toru Takada, Ryosuke Kuroda*, Kotaro Nishida*
- Organizer
  International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 動的圧迫負荷が,integrina5B1を介して脊索由来細胞に与える影響2018
- Author(s)
  神田　裕太郎+、角谷　賢一朗*、森田　有亮、由留部　崇*、垣内　裕司+、武岡　由樹+、蔵川　拓外、髙田　徹、土井田　稔、西田　康太郎*、黒田　良祐*
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] テムシロリムスのヒト椎間板髄核細胞保護効果はオートファジー及びAktの活性化に由来する2018
- Author(s)
  垣内　裕司+、由留部　崇*、角谷　賢一朗*、高田　徹、伊藤　雅明+、武岡　由樹+、神田　裕太郎+、黒田　良祐*、西田　康太郎*
- Organizer
  日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Involvement of autophagy in intervertebral disc degeneration and its contribution to cell homeostasis with the maintenance of notochordal phenotype2018
- Author(s)
  Yurube T, Ito M, Kakiuchi Y, Takeoka Y, Kakutani K, Takada T, Kanda Y, Miyazaki S, Kuroda R, Nishida K
- Organizer
  The 64th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] 細胞低接着性コラーゲン（Low Adhesive Scaffold Collagen：LASCol）による脊椎椎間板再生の可能性2018
- Author(s)
  武岡由樹、由留部崇、國井沙織、森本康一、深瀬直政、竹森俊幸、垣内裕司、伊藤雅明、神田裕太郎、角谷賢一朗、高田徹、黒田良祐、西田康太郎
- Organizer
  第47回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-18K16659
[Presentation] Autophagy plays protective roles against human disc cellular apoptosis, senescence, and extracellular matrix degradation2018
- Author(s)
  Masaaki Ito+, Takashi Yurube*, Kenichiro Kakutani*, Toru Takada, Yuji Kakiuchi+, Yoshiki Takeoka+, Yutaro Kanda+, Ryosuke Kuroda*, Kotaro Nishida*
- Organizer
  International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 椎間板動的圧迫負荷が脊索由来髄核細胞に及ぼした影響2018
- Author(s)
  神田祐太郎、角谷賢一朗、森田有亮、由留部　崇、伊藤雅明、垣内裕司、武岡由樹、蔵川拓外、寺島良樹、高田　徹、黒田良祐、西田康太郎
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 細胞低接着性コラーゲン（LASCol)を用いた脊椎椎間板再生の可能性2018
- Author(s)
  武岡由樹、由留部崇、國井沙織、森本康一、深瀬直政、竹森俊幸、垣内裕司、辻本龍、角谷賢一朗、髙田徹、黒田良祐、西田康太郎
- Organizer
  第8回DDS再生医療研究会・第10回多血小板血漿（PRP)療法研究会
- Data Source
  KAKENHI-PROJECT-18K16659
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス・セネッセンスを誘導するが、細胞外基質代謝への影響は少ない2018
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第47回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 細胞低接着性コラーゲン（Low Adhesive Scaffold Collagen：LASCol）を用いた脊椎椎間板再生の試み2018
- Author(s)
  武岡由樹、由留部崇、森本康一、國井沙織、深瀬直政、竹森俊幸、垣内裕司、角谷賢一朗、高田徹、黒田良祐、西田康太郎
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K16659
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor to protect human disc cells through AKT rather than autophagy induction2018
- Author(s)
  Kakiuchi Y, Yurube T, Takeoka Y, Ito M, Kanda Y, Kakutani K, Takada T, Kuroda R, Nishida K
- Organizer
  The 64th Annual Meeting, Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス・セネッセンスを誘導するが、細胞外基質代謝への影響は少ない2018
- Author(s)
  伊藤　雅明+、由留部　崇*、角谷　賢一朗*、髙田　徹、垣内　裕司+、武岡　由樹+、神田　裕太郎+、黒田　良祐*、西田　康太郎*
- Organizer
  日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Regenerative potential of the intervertebral disc by using the Low Adhesive Scaffold Collagen (LASCol)2018
- Author(s)
  Takeoka Y, Yurube T, Kunii S, Morimoto K, Fukase N, Takemori T, Kakiuchi Y, Ito M, Kanda Y, Kakutani K, Takada T, Kuroda R, Nishida K
- Organizer
  The 45th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16659
[Presentation] Autophagy plays protective roles against human disc cellular apoptosis, senescence, and extracellular matrix degradation2018
- Author(s)
  M. Ito, T. Yurube, K. Kakutani, T. Takada, Y. Kakiuchi, Y. Takeoka, Y. Kanda, R. Kuroda, K. Nishida
- Organizer
  45th The International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 細胞低接着性コラーゲン（Low Adhesive Scaffold Collagen：LASCol）による脊椎椎間板再生2018
- Author(s)
  武岡由樹、由留部崇、國井沙織、森本康一、竹森俊幸、深瀬直政、垣内裕司、角谷賢一朗、黒田良祐
- Organizer
  第55回日本リハビリテーション医学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16659
[Presentation] The fate of notochordal cell in intervertebral disc degeneration induced by dynamic compressive load through integrin alpha5/beta1 mechanotransduction2018
- Author(s)
  Yutaro Kanda+, Kenichiro Kakutani*, Yusuke Morita, Takashi Yurube*, Masaaki Ito+, Yuji Kakiuchi+, Yoshiki Takeoka+, Takuto Kurakawa, Yoshiki Terashima, Toru Takada, Ryosuke Kuroda*, Kotaro Nishida*
- Organizer
  International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Involvement of autophagy in intervertebral disc degeneration and its possible contribution to the maintenance of notochordal cell homeostasis2017
- Author(s)
  Yurube T, Hirata H, Ito M, Terashima Y, Kakiuchi Y, Takeoka Y, Miyazaki S, Kakutani K, Maeno K, Takada T, Kuroda R, Nishida K
- Organizer
  The 44th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] ATG5のノックダウンによるオートファジーの抑制はヒト椎間板細胞のアポトーシスとセネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K.
- Organizer
  The 44th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] 椎間板髄核におけるオートファジーの重要性とその脊索表現型保持への関与の可能性2017
- Author(s)
  由留部　崇、伊藤雅明、垣内裕司、寺島良樹、武岡由樹、角谷賢一郎、前野耕一郎、高田徹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 椎間板髄核におけるオートファジーの重要性とその脊索表現型保持への関与の可能性2017
- Author(s)
  由留部崇、伊藤雅明、垣内裕司、寺嶋良樹、武岡由樹、角谷賢一朗、前野耕一郎、高田徹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Selective mTORC1 inhibition through RNA interference for Raptor is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with Akt and autophagy induction2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  The 63rd Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Involvement of autophagy in intervertebral disc degeneration and its possible contribution to the maintenance of notochordal cell homeostasis2017
- Author(s)
  Takashi Yurube, Hiroaki Hirata, Masaaki Ito, Yoshiki Terashima, Yuji Kakiuchi, Yoshiki Takeoka, Shingo Miyazaki, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Ryosuke Kuroda, Kotaro Nishida
- Organizer
  The 44th International Society for the Study of the Lumbar Spine（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス、セネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、土井田稔、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] ATG5のノックダウンによるオートファジーの抑制はヒト椎間板細胞のアポトーシスとセネッセンスを誘導し、細胞数を減少させる。2017
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  The 44th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] 脊椎椎間板変性へのオートファジーの関与とその脊索由来細胞における恒常性維持機構の可能性2017
- Author(s)
  由留部　崇、伊藤雅明、垣内裕司、寺島良樹、武岡由樹、角谷賢一郎、前野耕一郎、高田　徹、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Involvement and roles of autophagy in maintaining notochordal cell homeostasis of the intervertebral disc nucleus pulposus2017
- Author(s)
  Yurube T, Ito M, Kakiuchi Y, Terashima Y, Takeoka Y, Kakutani K, Maeno K, Takada T, Kuroda R, Nishida K
- Organizer
  The 63rd Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス、セネッセンスを誘導し、細胞数を減少させる。2017
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、土井田稔、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor in human intervertebral disc nucleus pulposus cells.2017
- Author(s)
  Kakiuchi Y, Yurube T, Ito M, Takeoka Y, Terashima Y, Kakutani K, Maeno K, Takada T, Kuroda R, Nishida K
- Organizer
  63th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor for protecting human intervertebral disc nucleus pulposus cells2017
- Author(s)
  Kakiuchi Y, Yurube T, Takeoka Y, Ito M, Kakutani K, Maeno K, Takada T, Terashima Y, Kuroda R, Nishida K
- Organizer
  The 44th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  The 8th Annual Meeting of the Cervical Spine Research Society Asia Pacific Section
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] mTORC1阻害薬テムシロリムスはヒト椎間板髄核細胞において細胞死、細胞老化、細胞外基質分解を抑制する2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第36回運動器移植再生医学研究会
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] mTORC1阻害薬テムシロリムスはヒト椎間板髄核細胞において細胞死、細胞老化、細胞外基質分解を抑制する。2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第36回運動器移植再生医学研究会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence, resulting in reduced cellularity, in human intervertebral disc cells.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  63th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] ヒト椎間板髄核臍傍におけるmTOR阻害薬の細胞死、細胞老化、細胞外基質分解抑止効果の比較2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor for protecting human intervertebral disc nucleus pulposus cells2017
- Author(s)
  Kakiuchi Y, Yurube T, Takeoka Y, Ito M, Kakutani K, Maeno K, Takada T, Terashima Y, Kuroda R, Nishida K
- Organizer
  The 8th Annual Meeting of the Cervical Spine Research Society Asia Pacific Section
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] ATG5のノックダウンによるオートファジーの抑制はヒト椎間板細胞のアポトーシスとセネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田　徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] mTORシグナル経路におけるRAPTORへの選択的な干渉はヒト椎間板細胞における細胞死，細胞老化と細胞外基質分解を抑制する2017
- Author(s)
  由留部崇、伊藤雅明、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良佑、西田康太郎
- Organizer
  第30回日本軟骨代謝学会
- Place of Presentation
  京都市勧業館みやこめっせ（京都府京都市）
- Year and Date
  2017-03-03
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor in human intervertebral disc nucleus pulposus cells2017
- Author(s)
  Kakiuchi Y, Yurube T, Ito M, Takeoka Y, Terashima Y, Kakutani K, Maeno K, Takada T, Kuroda R, Nishida K
- Organizer
  The 63rd Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] オートファジーの抑制はヒト椎間板細胞においてアポトーシス、セネッセンスを誘導し、細胞数を減少させる2017
- Author(s)
  伊藤雅明、由留部　崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、垣内裕司、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Autophagy contributes to cell survival, anti-apoptosis, anti-senescence and extracellular matrix homeostasis in human disc nucleus pulposus cells2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  The 63rd Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells2017
- Author(s)
  Masaaki Ito, Takashi Yurube, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Yoshiki Terashima, Yuji Kakiuchi, Yoshiki Takeoka, Ryosuke Kuroda, Kotaro Nishida
- Organizer
  The 44th International Society for the Study of the Lumbar Spine（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Involvement of autophagy in intervertebral disc degeneration and its contribution to cell survival with the maintenance of notochordal phenotype2017
- Author(s)
  Yurube T, Hirata H, Ito M, Terashima Y, Kakiuchi Y, Takeoka Y, Kakutani K, Takada T, Miyazaki S, Kuroda R, Nishida K
- Organizer
  The 45th Annual Meeting, Cervical Spine Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] ヒト椎間板髄核臍傍におけるmTOR阻害薬の細胞死、細胞老化、細胞外基質分解抑止効果の比較。2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、黒田良祐、西田康太郎
- Organizer
  第46回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] ｍTORC1阻害薬テムシロリスムはヒト椎間板髄核細胞において細胞死、細胞老化、細胞外基質分解を抑制する2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、土井田稔、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Selective mTORC1 inhibition through RNA interference for RAPTOR is protective against human intervertebral disc cellular apoptosis, senescence, and extracellular matrix degradation with Akt and autophagy induction.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  63th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  San Diego (USA)
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor for protecting human intervertebral disc nucleus pulposus cells.2017
- Author(s)
  Kakiuchi Y, Yurube T, Takeoka Y, Ito M, Kakutani K, Maeno K, Takada T, Terashima Y, Kuroda R, Nishida K.
- Organizer
  The 44th Annual Meeting, International Society for the Study of the Lumbar Spine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Temsirolimus is a candidate of the optimal mTOR inhibitor in human intervertebral disc nucleus pulposus cells.2017
- Author(s)
  Kakiuchi Y, Yurube T, Ito M, Takeoka Y, Terashima Y, Kakutani K, Maeno K, Takada T, Kuroda R, Nishida K
- Organizer
  8th Annual Meeting of Cervical Spine Research Society -Asia Pacific Section-
- Place of Presentation
  Kobe (JAPAN)
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Inhibition of autophagy through ATG5 knock down induces apoptosis and senescence in human intervertebral disc cells.2017
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Terashima Y, Kakiuchi Y, Takeoka Y, Kuroda R, Nishida K
- Organizer
  8th Annual Meeting of Cervical Spine Research Society -Asia Pacific Section-
- Place of Presentation
  Kobe (JAPAN)
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] 脊椎椎間板変性へのオートファジーの関与とその脊索由来細胞における恒常性維持機構の可能性2017
- Author(s)
  由留部崇、伊藤雅明、寺嶋良樹、垣内裕司、武岡由樹、角谷賢一朗、前野耕一郎、高田徹、土井田稔、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] mTORC1阻害薬テムシロリスムはヒト椎間板髄核細胞において細胞死、細胞老化、細胞外基質分解を抑制する。2017
- Author(s)
  垣内裕司、由留部崇、角谷賢一朗、前野耕一郎、高田徹、寺嶋良樹、伊藤雅明、武岡由樹、土井田稔、黒田良祐、西田康太郎
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] 椎間板では他の筋骨格系組織よりもオートファジーの関与が大きく、その活性は変性とともに減少する：オートファジー制御による椎間板変性予防の可能性2016
- Author(s)
  由留部　崇、平田　裕亮、伊藤　雅明、垣内　裕司、角谷　賢一朗、前野　耕一郎、宮崎　真吾、寺嶋　良樹、黒坂　昌弘、西田　康太郎
- Organizer
  第45回日本脊椎脊髄病学会
- Place of Presentation
  千葉幕張、日本
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction.2016
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kakiuchi Y, Kurosaka M, Nishida K.
- Organizer
  43th Annual Meeting of the International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore (SINGAPORE)
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction.2016
- Author(s)
  Ito M, Yurube T, Maeno K, et.al.,
- Organizer
  The 43rd annual meeting of International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-16
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し、ヒト椎間板細胞における細胞死、老化と細胞外基質分解を抑制する2016
- Author(s)
  伊藤　雅明、由留部　崇、角谷　賢一朗、前野　耕一郎、高田　徹、宮崎　真吾、寺嶋　良樹、黒坂　昌弘、西田　康太郎
- Organizer
  第45回日本脊椎脊髄病学会
- Place of Presentation
  千葉幕張、日本
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し，ヒト椎間板細胞における細胞死，細胞老化と細胞外基質分解を抑制する：　椎間板遺伝子治療の可能性2016
- Author(s)
  伊藤雅明, 由留部崇, 角谷賢一朗, 前野耕一郎, 高田徹, 寺嶋良樹, 垣内裕司, 武岡由樹, 黒田良祐, 西田康太郎
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県博多市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し、ヒト椎間板細胞における細胞死、老化と細胞外基質分解を抑制する2016
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺嶋良樹、垣内裕司、黒坂昌弘、西田康太郎
- Organizer
  第45回日本脊椎脊髄病学会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] mTORシグナル経路への選択的な干渉はAktの活性化およびオートファジーを誘導し、ヒト椎間板における細胞死、老化と細胞外基質分解を抑制する。2016
- Author(s)
  伊藤雅明, 由留部崇, 角谷　賢一朗, 前野耕一郎, 高田徹, 宮崎　真吾, 寺嶋良樹, 垣内裕司, 黒坂昌弘, 西田康太郎
- Organizer
  第45回日本脊椎脊髄病学会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し、ヒト椎間板細胞における細胞死、細胞老化と細胞外基質分解を抑制する：椎間板遺伝子治療の可能性2016
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺嶋良樹、垣内裕司、黒坂昌弘、西田康太郎
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Intervertebral disc nucleus pulposus has intensive involvement of autophagy compared to other musculoskeletal tissues and its degeneration is linked with decreased autophagy2016
- Author(s)
  Yurube T., Hirata H., Ito M., Kakiuchi Y., Kakutani K., Maeno K., Takada T., Miyazaki S., Terashima Y., Kurosaka M., Nishida K.
- Organizer
  The International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Intervertebral disc nucleus pulposus has intensive involvement of autophagy compared to other musculoskeletal tissues and its degeneration is linked with decreased autophagy2016
- Author(s)
  Yurube T, Hirata H, Ito M, Kakiuchi Y, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kurosaka M, Nishida K
- Organizer
  The 4３ｒd Annual Meeting, International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore, Singapore
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction2016
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kakiuchi Y, Kurosaka M, Nishida K
- Organizer
  The 62nd Annual Meeting, Orthopaedic Research Society
- Place of Presentation
  Orlando, USA
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction2016
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kakiuchi Y, Kurosaka M, Nishida K
- Organizer
  The 43rd Annual Meeting of the International Society for the Study of the Lumbar Spine (Spineweek 2016)
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction2016
- Author(s)
  to M., Yurube T., Kakutani K., Maeno K., Takada T., Miyazaki S., Terashima Y., Kakiuchi Y., Kurosaka M., Nishida K.
- Organizer
  The International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 椎間板では他の筋骨格系組織よりもオートファジーの関与が大きく、その活性は変性とともに減少する：オートファジー制御による椎間板変性予防の可能性2016
- Author(s)
  由留部崇、平田裕亮、伊藤雅明、垣内裕司、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺島良樹、黒坂昌弘、西田康太郎
- Organizer
  第４５回　日本脊椎脊髄病学会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] mTORシグナル経路への選択的な干渉はAktの活性化およびオートファジーを誘導し、ヒト椎間板における細胞死・老化と細胞外基質分解を抑制する2016
- Author(s)
  伊藤雅明、由留部崇、前野耕一郎ほか
- Organizer
  第45回日本脊椎脊髄病学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K10406
[Presentation] mTORシグナル経路への選択的な干渉はオートファジーとAktの活性化を誘導し、ヒト椎間板細胞における細胞死、老化と細胞外気質分解を抑制する2016
- Author(s)
  伊藤雅明、由留部崇、角谷賢一朗、前野耕一郎、高田徹、宮崎真吾、寺島良樹、垣内裕司、黒坂昌弘、西田康太郎
- Organizer
  第４５回　日本脊椎脊髄病学会
- Place of Presentation
  千葉
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] 腰部脊柱管狭窄症に対する最小侵襲手術を目指した棘突起間スペーサーの開発2016
- Author(s)
  西田康太郎、前野耕一郎、角谷賢一朗、由留部　崇、高田　徹、伊藤雅明、寺嶋良樹、垣内裕司、武岡由樹
- Organizer
  第２４回　日本腰痛学会
- Place of Presentation
  山梨
- Year and Date
  2016-09-02
- Invited
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] Selective interference of mTOR signaling is protective against human disc cellular apoptosis, senescence, and extracellular matrix degradation with autophagy induction2016
- Author(s)
  Ito M, Yurube T, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kakiuchi Y, Kurosaka M, Nishida K
- Organizer
  The 4３ｒd Annual Meeting, International Society for the Study of the Lumbar Spine
- Place of Presentation
  Singapore, Singapore
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] 椎間板では他の筋骨格系組織よりもオートファジーの関与が大きく、その活性は変性とともに減少する：オートファジー制御による椎間板変性予防の可能性2016
- Author(s)
  由留部崇、平田裕亮、伊藤雅明、垣内裕司、角谷賢一朗、前野耕一郎、宮崎真吾、寺嶋良樹、黒坂昌弘、西田康太郎
- Organizer
  第45回日本脊椎脊髄病学会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] 脊椎椎間板髄核では他の筋骨格・神経組織よりもオートファジーの関与が大きく、変性が進行するとその活性は減少する2016
- Author(s)
  由留部崇、平田裕亮、伊藤雅明、垣内裕司、寺嶋良樹、角谷賢一朗、前野耕一郎、高田徹、黒坂昌弘、西田康太郎
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] 脊椎椎間板髄核におけるオートファジーの重要性とその誘導による椎間板変性予防の可能性2016
- Author(s)
  由留部崇、伊藤雅明、角谷賢一朗、前野耕一郎、黒田良佑、西田康太郎
- Organizer
  第127回中部日本整形外科災害外科学会学術集会
- Place of Presentation
  まつもと市民芸術館・ホテルブエナビスタ（長野県松本市）
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] 椎間板変性モデルについて2016
- Author(s)
  西田康太郎、由留部崇、高田徹、角谷賢一朗、前野耕一郎、伊藤雅明、寺嶋良樹、垣内裕司、武岡由樹
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Intervertebral disc nucleus pulposus has intensive involvement of autophagy compared to other musculoskeletal tissues and its degeneration is linked with decreased autophagy2016
- Author(s)
  Yurube T, Hirata H, Ito M, Kakiuchi Y, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kurosaka M, Nishida K
- Organizer
  The 43rd Annual Meeting of the International Society for the Study of the Lumbar Spine (Spineweek 2016)
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20051
[Presentation] Intervertebral disc nucleus pulposus is a major autophagy-involved musculoskeletal organ and its degeneration is linked with decreased autophagy2016
- Author(s)
  Yurube T, Hirata H, Ito M, Kakiuchi Y, Kakutani K, Maeno K, Takada T, Miyazaki S, Terashima Y, Kurosaka M, Nishida K
- Organizer
  The 62nd Annual Meeting, Orthopaedic Research Society
- Place of Presentation
  Orlando, USA
- Year and Date
  2016-03-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] Protective effects of rapamycin against intervertebral disc cellular apoptosis, senescence, and extracellular matrix degradation are linked to Akt phosphorylation as well as to autophagy induction2015
- Author(s)
  Yurube T, Lozito TP, Hartman RA, Pohl PHI, Zhang Z, Nishida K, Kurosaka M, Vo NV, Sowa GA, Kang JD
- Organizer
  The 42nd Annual Meeting, International Society for the Study of the Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] Rapamycin, but not other mTOR modulators, is protective against intervertebral disc cellular apoptosis, senescence, and extracellular matrix degradation2015
- Author(s)
  Yurube T, Lozito TP, Hartman RA, Pohl PHI, Zhang Z, Nishida K, Kurosaka M, Vo NV, Sowa GA, Kang JD
- Organizer
  The 42nd Annual Meeting, International Society for the Study of the Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] 神戸大式棘突起間スペーサーの開発2015
- Author(s)
  西田康太郎、前野耕一郎、角谷賢一朗、由留部崇
- Organizer
  第１４回　関西MISt 研究会
- Place of Presentation
  大阪
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-15H03033
[Presentation] The anti-aging agent rapamycin mitigates age-associated proteoglycan matrix loss in intervertebral discs of the nonhuman primate marmoset model2015
- Author(s)
  Prashanti P, Ngo K, Pohl P, Yurube T, Dong Q, Cory R, Tardif S, Sowa G, Kang J, Vo N
- Organizer
  The 42nd Annual Meeting, International Society for the Study of the Lumbar Spine
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] ラパマイシンの椎間板細胞保護作用はオートファジーの誘導だけでなく、Akt活性の上昇に由来している2015
- Author(s)
  由留部　崇、Sowa GA、Vo NV、西田　康太郎、黒坂　昌弘、Kang JD
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山、日本
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] 椎間板変性と坑老化因子との関係について2015
- Author(s)
  角谷　賢一朗、由留部　崇、前野　耕一郎、高田　徹、宮崎　真吾、寺嶋　良樹、伊藤　雅明、垣内　裕司、黒坂　昌弘、西田　康太郎
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山、日本
- Year and Date
  2015-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] mTORシグナル経路への選択的な干渉は椎間板における細胞死、老化と細胞外基質分解を抑制する2015
- Author(s)
  伊藤　雅明、由留部　崇、角谷　賢一朗、前野　耕一郎、高田　徹、寺嶋　良樹、宮崎　真吾、蔵川　拓外、黒坂　昌弘、西田　康太郎
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山、日本
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] Rapamycin, a mTORC1 inhibitor, has beneficial, but other mTOR modulators have harmful effects on the intervertebral disc cellular apoptosis, senescence, and extracellular matrix degradation2015
- Author(s)
  Yurube T, Sowa GA, Vo NV, Nishida K, Kurosaka M, Kang JD
- Organizer
  第44回日本脊椎脊髄病学会
- Place of Presentation
  福岡、日本
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] ラパマイシン以外のmTOR阻害薬は椎間板細胞におけるアポトーシス、セネッセンス、細胞外基質分解を抑制しない2015
- Author(s)
  由留部　崇、Sowa GA、Vo NV、西田　康太郎、黒坂　昌弘、Kang JD
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山、日本
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-26893151
[Presentation] Rapamycin, a mTORC1 inhibitor, protects the intervertebral disc against cellular apoptosis, senescence, and extracellular matrix degradation through Akt activation rather than autophagy induction
- Author(s)
  Yurube T, Lozito TP, Hartman RA, Pohl PHI, Zhang Z, Nishida K, Kurosaka M, Vo NV, Kang JD, Sowa GA
- Organizer
  The 61st Annual Meeting, Orthopaedic Research Society
- Place of Presentation
  Las Vegas, NV, USA
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-26893151

1. Kakutani Kenichiro (10533739)

# of Collaborated Projects: 7 results

# of Collaborated Products: 75 results
2. Zhang Zhongying (00824195)

# of Collaborated Projects: 4 results

# of Collaborated Products: 28 results
3. 垣内裕司 (40849212)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
4. Maeno Koichiro (70403269)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
5. Nishida Kotaro (00379372)

# of Collaborated Projects: 2 results

# of Collaborated Products: 39 results
6. 武岡由樹 (30943592)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
7. Matsushita Takehiko (40467650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高田徹 (00598526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
9. 豊田紀章 (00382276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 松本知之 (50546588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高山孝治 (80546490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 田畑泰彦 (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西田英高 (00622804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Miyazaki Shingo

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. Terashima Yoshiki

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
16. Ito Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
17. MORIMOTO Kouichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yurube Takashi 由留部 崇

YURUBE Takashi 由留部 崇

Research Projects

Research Products

Co-Researchers

Development of gene therapy for intervertebral disc degeneration by using cationized gelatin nanospheresPrincipal Investigator

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アディポネクチンによる椎間板変性・炎症に対する治療法の開発

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Development of gene and pharmacological therapies for intervertebral disc degeneration by modulating mTORC1Principal Investigator

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the study of new treatment for spinal metastasis with the combination of sustained release anti-cancer drug and non-metal spinal instrumentation

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Development of a new treatment against intervertebral disc degeneration and inflammation using adiponectin

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Development of new therapeutic drugs for osteoarthritis targeting mTORC1

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Regeneration of the intervertebral disc in the spine by Low Adhesive Scaffold Collagen (LASCol)Principal Investigator

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Development of treatment strategies for intervertebral disc degeneration by modulating mTOR signalingPrincipal Investigator

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The approach of molecular treatments for the intervertebral disc degeneration.

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Elucidation of pathogenesis of low back pain related to degeneration of intervertebral disc and development of minimally invasive treatment system

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Development of treatment strategies for intervertebral disc degeneration by modulating autophagyPrincipal Investigator

Principal Investigator

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[Journal Article] Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting <scp>mTORC1</scp> and inducing autophagy through Akt activation2024

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[Journal Article] Anti-Inflammatory Effects of Adiponectin Receptor Agonist AdipoRon against Intervertebral Disc Degeneration2023

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Yurube Takashi 由留部崇

YURUBE Takashi 由留部崇

[Journal Article] 特集椎間板の基礎と臨床椎間板変性とオートファジー2023