HATA Nobuhiro 秦暢宏

Researcher Number	10596034
Other IDs	https://orcid.org/0000-0002-5523-7166
Affiliation *help	2017 – 2018 : 九州大学, 大学病院, 講師 2016 : 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 医師 2011 – 2013 : 九州大学, 大学病院, 助教 2013 : 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, その他 2013 : 独立行政法人国立病院機構九州医療センター, 臨床研究センター
Review Section/Research Field	Principal Investigator Neurosurgery / Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery / Neurosurgery / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator glioma / glioblastoma / トランスレーショナルリサーチ / 神経膠腫 / next-generation sequencing / IDH / 脳腫瘍 / 1p/19q LOH / TERT / IDH1 … More Except Principal Investigator バイオマーカー / 脳腫瘍 / microRNA / glioma / エキソソーム / 脳動脈瘤 / 神経膠腫 / グリオーマ / 分子病理学 / エクソソーム / 間葉系幹細胞 / マクロファージ / 頭蓋内胚細胞腫瘍 / DNA損傷応答 / micro RNA / exosome / 膠芽腫 Less

新規バイオマーカーに基づく頭蓋内胚細胞腫瘍の革新的診断／治療システムの開発Ongoing
- Principal Investigator
  
  空閑太亮
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Keio University
グリオーマの分子病理学的診断のための、統合的解析プラットフォームの構築Principal InvestigatorOngoing
- Principal Investigator
  
  秦暢宏
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  National Hospital Organization, Kyushu Medical Center (Clinical Institute)
Investigation of brain tumor derived exosomes; the role in tumorigeneity and therapy
- Principal Investigator
  
  Mizoguchi Masahiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyushu University
Potential novel treatment approach for cerebral aneurysm with mesenchymal stem cell
- Principal Investigator
  
  NAKAMIZO AKIRA
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyushu University
The dynamics of DNA damage response in glioblastoma-Toward the development of new therapy-
- Principal Investigator
  
  YOSHIMOTO KOJI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyushu University
Identification of a novel biomarker of brain tumor based on the analysis of exosomal microRNA
- Principal Investigator
  
  MIZOGUCHI Masahiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyushu University
Comprehensive analysis of glioma LOH regions using next-generation sequencingPrincipal Investigator
- Principal Investigator
  
  HATA Nobuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kyushu University

All 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Insular primary glioblastomas with IDH mutations: Clinical and biological specificities.2017
- Author(s)
  Hata N, Hatae R, Yoshimoto K, Murata H, Kuga D, Akagi Y, Sangatsuda Y, Suzuki SO, Iwaki T, Mizoguchi M, Iihara K.
- Journal Title
  
  Neuropathology
  
  Volume : 印刷中 Pages : 200-207
- DOI
  10.1111/neup.12362
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K10779, KAKENHI-PROJECT-16K20015, KAKENHI-PROJECT-15K15529
[Journal Article] Add-on bevacizumab can prevent early clinical deterioration and prolong survival in newly diagnosed partially resected glioblastoma patients with a poor performance status.2017
- Author(s)
  Hata N, Yoshimoto K, Hatae R, Kuga D, Akagi Y, Sangatsuda Y, Suzuki SO, Shono T, Mizoguchi M, Iihara K.
- Journal Title
  
  Onco Targets Ther.
  
  Volume : 10 Pages : 429-437
- DOI
  10.2147/OTT.S125587
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K10779, KAKENHI-PROJECT-16K20015, KAKENHI-PROJECT-15K15529
[Journal Article] A comprehensive analysis identifies BRAF hotspot mutations associated with gliomas with peculiar epithelial morphology.2016
- Author(s)
  Hatae R, Hata N, Suzuki SO, Yoshimoto K, Kuga D, Murata H, Akagi Y, Sangatsuda Y, Iwaki T, Mizoguchi M, Iihara K.
- Journal Title
  
  Neuropathology
  
  Volume : 28 Pages : 191-199
- DOI
  10.1111/neup.12347
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15529, KAKENHI-PROJECT-16K10779, KAKENHI-PROJECT-16K20015
[Journal Article] Deferred radiotherapy and upfront procarbazine-ACNU-vincristine administration for 1p19q codeleted oligodendroglial tumors are associated with favorable outcome without compromising patient performance, regardless of WHO grade.2016
- Author(s)
  Hata N, Yoshimoto K, Hatae R, Kuga D, Akagi Y, Suzuki SO, Iwaki T, Shono T, Mizoguchi M, Iihara K.
- Journal Title
  
  OncoTargets and Therapy
  
  Volume : 9 Pages : 7123-7131
- DOI
  10.2147/OTT.S115911
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15529, KAKENHI-PROJECT-16K10779, KAKENHI-PROJECT-16K20015
[Journal Article] Precise Detection of IDH1/2 and BRAF Hotspot Mutations in Clinical Glioma Tissues by a Differential Calculus Analysis of High-Resolution Melting Data.2016
- Author(s)
  Hatae R, Hata N, Yoshimoto K, Kuga D, Akagi Y, Murata H, Suzuki SO, Mizoguchi M, Iihara K.
- Journal Title
  
  PLoS One.
  
  Volume : 11
- DOI
  10.1371/journal.pone.0160489
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K10779
[Journal Article] Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression.2015
- Author(s)
  Hideki Murata･Koji Yoshimoto･Ryusuke Hatae･Yojiro Akagi･Masahiro Mizoguchi･Nobuhiro Hata･Daisuke Kuga･Akira Nakamizo･Toshiyuki Amano･Tetsuro Sayama･Koji Iihara
- Journal Title
  
  J Neurooncol
  
  Volume : 125 Pages : 33-41
- DOI
  10.1007/s11060-015-1886-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462185, KAKENHI-PROJECT-15K15529, KAKENHI-PROJECT-25293311
[Journal Article] Clinical implications of microRNAs in human glioblastoma2013
- Author(s)
  Mizoguchi M, Guan Y, Yoshimoto K, Hata N, Amano T, Nakamizo A, Sasaki T
- Journal Title
  
  Frontiers in Oncology
  
  Volume : 3 Pages : 19-19
- DOI
  10.3389/fonc.2013.00019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390280, KAKENHI-PROJECT-23659691
[Journal Article] Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma2012
- Author(s)
  Xinlong Ma
- Journal Title
  
  Neuro Oncol
  
  Volume : 14 Pages : 1153-1162
- DOI
  10.1093/neuonc/nos145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390279, KAKENHI-PROJECT-22390280, KAKENHI-PROJECT-23659691
[Journal Article] Molecular characteristics of glioblastoma with 1p/19q co-deletion.2012
- Author(s)
  Mizoguchi M, Yoshimoto K, Ma X, Guan Y, Hata N, Amano T, Nakamizo A, Suzuki SO, Iwaki T, Sasaki T
- Journal Title
  
  Brain Tumor Pathol
  
  Volume : 29(3) Pages : 148-53
- DOI
  10.1007/s10014-012-0107-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390280, KAKENHI-PROJECT-23500429, KAKENHI-PROJECT-23659691
[Journal Article] Molecular biomarkers of glioblastoma: current targets and clinical implications2012
- Author(s)
  Yoshimoto K, Mizoguchi M, Hata N, et. al.
- Journal Title
  
  Current Biomarker Findings
  
  Volume : 2 Pages : 63-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791608
[Journal Article] Molecular characteristics of glioblastoma with 1p/19q co-deletion2012
- Author(s)
  Mizoguchi M, Yoshimoto K, Ma X, Guan Y, Hata N, et. al.
- Journal Title
  
  Brain Tumor Pathol.
  
  Volume : 29 Pages : 148-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791608
[Journal Article] MicroRNAs in Human Malignant Gliomas2012
- Author(s)
  Mizoguchi M, Guan Y, Yoshimoto K, Hata N, Amano T, Nakamizo A, Sasaki T
- Journal Title
  
  J Oncol
  
  Volume : 2012 Pages : 732874-732874
- DOI
  10.1155/2012/732874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390280, KAKENHI-PROJECT-23659691
[Journal Article] Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma2012
- Author(s)
  Yoshimoto K, Mizoguchi M, Hata N, Murata H, Hatae R, Amano T, Nakamizo A, Sasaki T
- Journal Title
  
  Frontiers in Oncology
  
  Volume : 2 Pages : 186-186
- DOI
  10.3389/fonc.2012.00186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390280, KAKENHI-PROJECT-23659691
[Journal Article] Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma.2012
- Author(s)
  Ma X, Yoshimoto K, Guan Y, Hata N, Mizoguchi M, et. al.
- Journal Title
  
  Neuro Oncol.
  
  Volume : 14 Pages : 1153-1162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791608
[Journal Article] Molecular biomarkers of glioblastoma: current targets and clinical implications2012
- Author(s)
  Yoshimoto K, Mizoguchi M, Hata N, Amano T, Nakamizo A, Sasaki T
- Journal Title
  
  Current Biomarker Findings
  
  Volume : 2012(2) Pages : 63-76
- URL
  http://dx.doi.org/10.2147/CBF.S25590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659691
[Journal Article] Loss of heterozygosity analysis in malignant gliomas2011
- Author(s)
  Mizoguchi M, Kuga D, Guan Y, Hata N, Nakamizo A, Yoshimoto K, Sasaki T
- Journal Title
  
  Brain Tumor Pathol
  
  Volume : 28(3) Pages : 191-6
- DOI
  10.1007/s10014-011-0038-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390280, KAKENHI-PROJECT-23659691
[Presentation] 1p19q co-deletionを有する oligodendrogliomaに対するPAV先行治療：分子診断による治療層別化の長期成績2017
- Author(s)
  秦暢宏、吉本幸司、空閑太亮、波多江龍亮、赤木洋二郎、鈴木諭、岩城徹、溝口昌弘、飯原弘二
- Organizer
  第34回日本脳腫瘍病理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16K10779
[Presentation] Deferred Radiotherapy and Upfront Procarbazine-ACNU-Vincristine Administration for 1p19q Codeleted Oligodendroglial Tumors is Associated with Favorable Outcome without Compromising Patient Performance, Regardless of WHO Grade2016
- Author(s)
  Nobuhiro HATA, Koji YOSHIMOTO, Daisuke KUGA, Ryusuke HATAE, Yojiro AKAGI, Satoshi O SUZUKI, Toru IWAKI, Masahiro MIZOGUCHI, Koji IIHARA
- Organizer
  The 14th Young-Honam and Kyushu Neurosurgical Joint Meeting
- Place of Presentation
  福岡県　福岡市
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10779
[Presentation] 初発神経膠芽腫に対するBevacizumab併用療法の治療成績2016
- Author(s)
  秦暢宏、吉本幸司、空閑太亮、波多江龍亮、赤木洋二郎、三月田祐平、溝口昌弘、、飯原弘二
- Organizer
  第34回日本脳腫瘍学会
- Place of Presentation
  山梨県　甲府市
- Data Source
  KAKENHI-PROJECT-16K10779
[Presentation] 初発膠芽腫に対するBevacizumab承認後の新規治療戦略：現況と展望2016
- Author(s)
  秦暢宏、吉本幸司、溝口昌弘、波多江龍亮、赤木洋二郎、三月田祐平、空閑太亮、庄野禎久、飯原弘二
- Organizer
  第75回日本脳神経外科学会総会
- Place of Presentation
  福岡県　福岡市
- Data Source
  KAKENHI-PROJECT-16K10779
[Presentation] IDH/TERT変異解析による、グリオーマの分子病理学的層別化：255症例の検討2015
- Author(s)
  波多江龍亮、秦暢宏、赤木洋二郎、村田秀樹、空閑太亮、吉本幸司、溝口昌弘、飯原弘二
- Organizer
  日本脳神経外科学会第74回学術総会
- Place of Presentation
  北海道札幌市
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-25293311
[Presentation] 神経膠芽腫症例におけるBRAF遺伝子点突然変異解析2015
- Author(s)
  波多江龍亮、秦暢宏、鈴木諭、赤木洋二郎、村田秀樹、天野敏之、吉本幸司、溝口昌弘、飯原弘二
- Organizer
  第33回日本脳腫瘍病理学会
- Place of Presentation
  香川県高松市
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-25293311
[Presentation] pGBMにおけるIDH/TERT promoter/ch10 LOHの解析2015
- Author(s)
  波多江龍亮、秦暢宏、赤木洋二郎、村田秀樹、空閑太亮、吉本幸司、溝口昌弘、飯原弘二
- Organizer
  第33回日本脳腫瘍学会学術集会
- Place of Presentation
  京都府京都市
- Year and Date
  2015-12-06
- Data Source
  KAKENHI-PROJECT-25293311
[Presentation] Long-term outcome of patients with oligodendroglial tumors treated up-front with PAV therapy2013
- Author(s)
  秦　暢宏
- Organizer
  Joint Neurosurgical Convention 2013
- Place of Presentation
  Hawaii Wailkoloa Village (Hawaii)
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] 神経膠腫におけるmicroRNA発現解析の意義2013
- Author(s)
  溝口昌弘、吉本幸司、村田秀樹、波多江龍亮、秦暢宏、天野敏之、中溝玲
- Organizer
  日本脳神経外科学会第72回学術総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-25293311
[Presentation] High grade glioma 診断における遺伝子解析の役割2013
- Author(s)
  溝口昌弘、吉本幸司、秦暢宏、村田秀樹、波多江龍亮、天野敏之、中溝玲、鈴木論、岩城徹、佐々木富男
- Organizer
  第31回日本脳腫瘍病理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293311
[Presentation] IDH mutant primary GBMの臨床像2011
- Author(s)
  秦　暢宏
- Organizer
  第29回日本脳腫瘍学会
- Place of Presentation
  下呂温泉水明館(岐阜）
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] grade II, IIIグリオーマの遺伝子解析と治療成績：IDH1 mutationは予後因子か？2011
- Author(s)
  秦　暢宏
- Organizer
  第70回日本脳神経外科学会総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] ダイレクトシークエンス法によるIDH1 mutation解析：グリオーマ126例での検討2011
- Author(s)
  秦　暢宏
- Organizer
  第29回日本脳腫瘍病理学会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] HRM法によるIDH1 mutation解析
- Author(s)
  秦　暢宏
- Organizer
  第30回日本脳腫瘍病理学会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] テモダール時代において、PAV療法はOligodendroglial tumorに対する有用な選択肢となり得るか？
- Author(s)
  秦　暢宏
- Organizer
  日本脳神経外科学会第71回学術総会
- Place of Presentation
  大阪国際会議場（大阪）
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] IDH1 /2変異解析簡便化の試み
- Author(s)
  秦　暢宏
- Organizer
  第30回日本脳腫瘍学会学術集会
- Place of Presentation
  グランドプリンスホテル広島（広島）
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] 高齢者に対するテモダール放射線同期療法の治療成績
- Author(s)
  秦　暢宏
- Organizer
  第26回日本老年脳神経外科学会
- Place of Presentation
  東京ステーションコンファレンス（東京）
- Data Source
  KAKENHI-PROJECT-23791608
[Presentation] 高解像度融解曲線法(HRM)によるBRAF V600E 及びH3F3A変異解析の試み
- Author(s)
  波多江龍亮、秦暢宏、赤木洋二郎、村田秀樹、天野敏之、吉本幸司、溝口昌弘、飯原弘二
- Organizer
  第73回脳神経外科学会学術総会
- Place of Presentation
  東京
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-25293311
[Presentation] GliomaにおけるBRAF点突然変異の解析
- Author(s)
  波多江龍亮、秦暢宏、赤木洋二郎、村田秀樹、天野敏之、吉本幸司、溝口昌弘、飯原弘二
- Organizer
  第32回日本脳腫瘍学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2014-11-30 – 2014-12-02
- Data Source
  KAKENHI-PROJECT-25293311
[Presentation] Secondary glioblastoma症例における免疫染色法によるIDH1遺伝子変異同定について～シークエンス法との比較～
- Author(s)
  波多江龍亮、秦暢宏、赤木洋二郎、村田秀樹、天野敏之、中溝玲、鈴木諭、吉本幸司、溝口昌弘、飯原弘二
- Organizer
  第32回脳腫瘍病理学会
- Place of Presentation
  徳島
- Year and Date
  2014-05-23 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25293311

1. YOSHIMOTO Koji (70444784)

# of Collaborated Projects : 4results

# of Collaborated Products : 25results
2. NAKAMIZO Akira (80529800)

# of Collaborated Projects : 4results

# of Collaborated Products : 11results
3. AMANO Toshiyuki (70448413)

# of Collaborated Projects : 4results

# of Collaborated Products : 13results
4. MIZOGUCHI Masahiro (50380621)

# of Collaborated Projects : 2results

# of Collaborated Products : 20results
5. 空閑太亮 (40759932)

# of Collaborated Projects : 2results

# of Collaborated Products : 9results
6. KIKKAWA Yuichiro (80423515)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 赤木洋二郎 (10570773)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. IWAKI Toru

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
9. MURATA Hideki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
10. 鈴木諭

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. 飯原弘二

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 佐山徹郎

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

HATA Nobuhiro 秦 暢宏

Research Projects

Research Products

Co-Researchers

新規バイオマーカーに基づく頭蓋内胚細胞腫瘍の革新的診断／治療システムの開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グリオーマの分子病理学的診断のための、統合的解析プラットフォームの構築Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of brain tumor derived exosomes; the role in tumorigeneity and therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Potential novel treatment approach for cerebral aneurysm with mesenchymal stem cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The dynamics of DNA damage response in glioblastoma-Toward the development of new therapy-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a novel biomarker of brain tumor based on the analysis of exosomal microRNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of glioma LOH regions using next-generation sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Insular primary glioblastomas with IDH mutations: Clinical and biological specificities.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Add-on bevacizumab can prevent early clinical deterioration and prolong survival in newly diagnosed partially resected glioblastoma patients with a poor performance status.2017

Author(s)

Journal Title

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[Journal Article] A comprehensive analysis identifies BRAF hotspot mutations associated with gliomas with peculiar epithelial morphology.2016

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[Journal Article] Deferred radiotherapy and upfront procarbazine-ACNU-vincristine administration for 1p19q codeleted oligodendroglial tumors are associated with favorable outcome without compromising patient performance, regardless of WHO grade.2016

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[Journal Article] Precise Detection of IDH1/2 and BRAF Hotspot Mutations in Clinical Glioma Tissues by a Differential Calculus Analysis of High-Resolution Melting Data.2016

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[Journal Article] Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression.2015

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[Journal Article] Clinical implications of microRNAs in human glioblastoma2013

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HATA Nobuhiro 秦暢宏