Yamada Daisuke 山田大輔

Researcher Number	10621302
Other IDs	https://orcid.org/0000-0002-6989-6736
Affiliation (Current)	2025: 東京理科大学, 薬学部薬学科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京理科大学, 薬学部薬学科, 講師 2018 – 2022: 東京理科大学, 薬学部薬学科, 助教 2016 – 2017: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 科研費研究員 2015: 国立研究開発法人国立精神・神経医療研究センター, 疾病研究第四部, 科研費研究員
Review Section/Research Field	Principal Investigator Basic Section 46030:Function of nervous system-related / Psychiatric science Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 47040:Pharmacology-related / Psychiatric science
Keywords	Principal Investigator 神経回路 / 情動神経回路 / オピオイドδ受容体 / シナプス可塑性 / 扁桃体 / カンナビノイド / 恐怖記憶 / 多価不飽和脂肪酸 / 自律神経系 / 脳腸相関 … More / 代理社会的敗北ストレス / 病態モデル / 過敏性腸症候群 / δオピオイド受容体 / 島皮質 / 情動行動 / オピオイド / 抗不安 / 不安 / 内側前頭前野 / 不安様行動 / 不飽和脂肪酸 / ドーパミン / 腹側被蓋野 / 側坐核 / ドパミン / うつ様行動 / 長期増強 / 恐怖神経回路 / オプトジェネティクス / 聴覚野 … More Except Principal Investigator 内側前頭前野 / オピオイド / 情動行動 / 不安 / 恐怖記憶 / ラットモデル / マイクロウエーブ / びまん性脳損傷 / 光遺伝学 / 神経回路 / 動物モデル / 記憶・学習 / 精神薬理学 / 抗うつ薬 / オピオイド受容体 / 抑うつ / 海馬 / 扁桃体 / 情動 / 消去学習 / 恐怖 / ERK / 抗不安薬 / PTSD / オピオイドδ受容体 Less

末梢－中枢連環による情動変容におけるオピオイドδ受容体の機能解明Principal Investigator
- Principal Investigator
  
  山田大輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Tokyo University of Science
マイクロ波びまん性脳損傷に対する病態可視化と集学的治療の開発
- Principal Investigator
  
  横堀将司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Nippon Medical School
Region-specific regulation of anxiety and fear in the medial prefrontal cortex via delta-opioid receptors.
- Principal Investigator
  
  斎藤顕宜
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo University of Science
Elucidation of regulatory mechanism of neural circuit of emotion regulation through delta-opioid receptorsPrincipal Investigator
- Principal Investigator
  
  Yamada Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Tokyo University of Science
Elucidation of the neural circuit mechanism of antidepressant-like effect of dietary polyunsaturated fatty acidsPrincipal Investigator
- Principal Investigator
  
  Yamada Daisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo University of Science
  National Center of Neurology and Psychiatry
The mechanisms of the anxiolytic-like effects induced by delta opioid receptor agonists using conditioned fear test in mice
- Principal Investigator
  
  Saitoh Akiyoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo University of Science
  National Center of Neurology and Psychiatry
Elucidation of underlying mechanism for the modulation of fear circuit by dietary polyunsaturated fatty acidsPrincipal Investigator
- Principal Investigator
  
  Yamada Daisuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  National Center of Neurology and Psychiatry

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] ファルマシア52巻4号2016
- Author(s)
  山田大輔
- Total Pages
  1
- Publisher
  日本薬学会
- Data Source
  KAKENHI-PROJECT-15K21653
[Journal Article] The delta opioid receptor agonist <scp>KNT</scp>‐127 relieves innate anxiety‐like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala2023
- Author(s)
  Kawaminami Ayako、Yamada Daisuke、Yoshioka Toshinori、Hatakeyama Azumi、Nishida Moeno、Kajino Keita、Saitoh Tsuyoshi、Nagase Hiroshi、Saitoh Akiyoshi
- Journal Title
  
  Neuropsychopharmacology Reports
  
  Volume: 44 Issue: 1 Pages: 256-261
- DOI
  10.1002/npr2.12406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06636
[Journal Article] δオピオイド受容体を介した情動行動制御とその神経メカニズム2022
- Author(s)
  山田大輔、斎藤顕宜
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 157 Pages: 448-452
- Data Source
  KAKENHI-PROJECT-20K06930
[Journal Article] 情動調節におけるδオピオイド受容体の役割とそのメカニズム2022
- Author(s)
  山田大輔, 斎藤顕宜
- Journal Title
  
  Precision Medicine
  
  Volume: 5 Pages: 84-89
- Data Source
  KAKENHI-PROJECT-20K06930
[Journal Article] オピオイドの情動における役割 δ受容体を介した情動調節の分子・神経回路2022
- Author(s)
  河南絢子、山田大輔、斎藤顕宜
- Journal Title
  
  LiSA
  
  Volume: 29 Pages: 181-187
- Data Source
  KAKENHI-PROJECT-20K06930
[Journal Article] Selective δ-opioid receptor agonist, KNT-127, facilitates contextual fear extinction via infralimbic cortex and amygdala in mice2022
- Author(s)
  Kawaminami A, Yamada D, Yanagisawa S, Shirakata M, Iio K, Nagase H, Saitoh A
- Journal Title
  
  Frontiers in Behavioral Neuroscience
  
  Volume: 16 Pages: 808232-808232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06930
[Journal Article] Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice.2021
- Author(s)
  Yamada D, Takahashi J, Iio K, Nagase H, Saitoh A.
- Journal Title
  
  Biochemical & Biophysical Research Communications
  
  Volume: 560 Pages: 192-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06930
[Journal Article] Are δ-Opioid Receptor Agonists with Facilitating Effects on Fear Extinction Learning Candidates for the Treatment of Post-Traumatic Stress Disorder?2021
- Author(s)
  Saitoh A, Kawaminami A, Yamada D
- Journal Title
  
  Journal of Basic and Clinical Pharmacy
  
  Volume: 12 Pages: 92-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06930
[Journal Article] Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids2020
- Author(s)
  Takeuchi Eri、Yamada Daisuke、Suzuki Satoshi、Saitoh Akiyoshi、Itoh Masayuki、Hayashi Takashi、Yamada Mitsuhiko、Wada Keiji、Sekiguchi Masayuki
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 3 Pages: e0230647-e0230647
- DOI
  10.1371/journal.pone.0230647
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08086, KAKENHI-PROJECT-17K07124, KAKENHI-PROJECT-17K18402
[Journal Article] Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice2019
- Author(s)
  DaisukeYamada,Shoko Yanagisawa, Kazumi Yoshizawa, Shinya Yanagita, Jun-Ichiro Oka, Hiroshi Nagase, Akiyoshi Saitoh
- Journal Title
  
  NEUROPHARMACOLOGY
  
  Volume: 160 Pages: 111974-111974
- DOI
  10.1016/j.neuropharm.2019.107792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10830, KAKENHI-PROJECT-17K10286
[Journal Article] オピオイドδ受容体をターゲットとした向精神薬の可能性2017
- Author(s)
  斎藤顕宜、山田光彦
- Journal Title
  
  精神科
  
  Volume: 30 Pages: 95-99
- Data Source
  KAKENHI-PROJECT-17K10286
[Journal Article] Modulation of long-term potentiation of cortico-amygdala synaptic responses and auditory fear memory by dietary polyunsaturated fatty acid2016
- Author(s)
  Daisuke Yamada, Keiji Wada, Masayuki Sekiguchi
- Journal Title
  
  Frontiers in Behavioral Neuroscience
  
  Volume: 10 Pages: 1-10
- DOI
  10.3389/fnbeh.2016.00164
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K21653, KAKENHI-PROJECT-15K06730
[Presentation] Mechanisms of inhibitory effects of fear memory reconsolidation in mice by opioid δ-receptor agonists.2023
- Author(s)
  Ayako Kawaminami, Daisuke Yamada, Toshinori Yoshioka, Azumi Hatakeyama, Keita Kajino, Hiroshi Nagase, Akiyoshi Saitoh
- Organizer
  第９７回薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K06636
[Presentation] 過敏性腸症候群様症状を示すモデル動物の確立とδオピオイド受容体を介した症状改善作用のメカニズム解析2023
- Author(s)
  山田大輔、吉岡寿倫、濱野匠、山﨑万有奈、公木彩夏、松本健次郎、飯尾啓太、羽田紀康、加藤伸一、長瀬博、斎藤顕宜
- Organizer
  日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-23K06019
[Presentation] 内側前頭前野前辺縁皮質-偏桃体規定外側核神経回路は不安様行動の発現に関与する2022
- Author(s)
  河南絢子、西田萌乃、山田大輔、飯尾啓太、長瀬博、斎藤顕宜
- Organizer
  第45回日本神経科学会・第65回日本神経科学会大会・第32回日本神経回路学会大会
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] δオピオイド受容体作動薬による恐怖記憶の消去促進とその作用脳部位・分子メカニズムの検討2022
- Author(s)
  山田大輔、河南絢子、飯尾啓太、長瀬博、斎藤顕宜
- Organizer
  第14回日本不安症学会学術大会
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] 情動行動制御におけるオピオイド受容体の役割2022
- Author(s)
  山田大輔、斎藤顕宜
- Organizer
  BPCNPNPPP４学会合同年会
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] オピオイドδ受容体を介した情動制御メカニズム2022
- Author(s)
  山田大輔、斎藤顕宜
- Organizer
  第95回日本薬理学会年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] オピオイドδ受容体を介した恐怖記憶制御とその脳内メカニズムの検討2021
- Author(s)
  山田大輔、河南絢子、白方基揮、飯尾啓太、長瀬博、斎藤顕宜
- Organizer
  第40回鎮痛薬・オピオイドペプチドシンポジウム
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] Delta-opioid receptors in the insular cortex participate in the regulation of intestinal motility change induced by emotional chronic social defeat stress in mice2021
- Author(s)
  Daisuke Yamada, Misaki Ohashi, Toshinori Yoshhioka, Tomoki Omata, Kenjiro Matsumoto, Riho Kobayashi, Kotaro Okano, Momoka Nakatani, Keita Iio, Hiroshi Nagase, Shinichi Kato, Akiyoshi Saitoh.
- Organizer
  第44回日本神経科学大会第1回CJK国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] オピオイドδ受容体を介した内側前頭前野グルタミン酸神経伝達と神経細胞膜興奮性の修飾2021
- Author(s)
  山田大輔、飯尾啓太、長瀬博、斎藤顕宜
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] 内側前頭前野におけるデルタオピオイド受容体を介したグルタミン酸作動性シナプス伝達の修飾2021
- Author(s)
  山田大輔、飯尾啓太、長瀬博、斎藤顕宜
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] 恐怖記憶の消長におけるδオピオイド神経系の役割2021
- Author(s)
  山田大輔、斎藤顕宜
- Organizer
  第30回神経行動薬理若手研究者の集い（第94回日本薬理学会年会サテライトシンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] オピオイドδ受容体をターゲットとした向精神薬開発2021
- Author(s)
  斎藤顕宜、山田大輔、長瀬博
- Organizer
  第40回鎮痛薬・オピオイドペプチドシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K06930
[Presentation] KNT-127, but not SNC80, facilitates extinction learning of contextual fear memory via delta opioid receptor in mice2019
- Author(s)
  Akiyoshi Saitoh, Daisuke Yamada, Shoko Yanagisawa, Shinya Yanagita, Jun-Ichiro Oka, Hiroshi Nagase
- Organizer
  International Narcotics Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10286
[Presentation] Modulation of excitatory synaptic transmission via δ-opioid receptors in the mouse cerebral cortex2019
- Author(s)
  Daisuke Yamada, Jun-ichiro Oka, Hiroshi Nagase, Akiyoshi Saitoh
- Organizer
  The 42nd Annual Meeting of the Japan Neuroscience Society, The 62nd Annual Meeting of the Japanese for Neurochemistry
- Data Source
  KAKENHI-PROJECT-17K10286
[Presentation] 文脈的恐怖条件づけ試験における選択的δオピオイド受容体作動薬の消去学習に対する影響2019
- Author(s)
  柳澤祥子、山田大輔、長瀬博、斎藤顕宜
- Organizer
  第139回日本薬学会
- Data Source
  KAKENHI-PROJECT-17K10286
[Presentation] Selective agonists for delta-opioid receptor, KNT-127 and SNC80, differentially act on extinction learning of contextual fear memory in mice2019
- Author(s)
  Daisuke Yamada, Shoko Yanagisawa, Shinya Yanagita, Jun-Ichiro Oka, Hiroshi Nagase, Akiyoshi Saitoh
- Organizer
  Society for Neuroscience 49th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10286
[Presentation] KNT127, a selective agonist for delta-receptors, modulates excitatory synaptic transmission in the medial prefrontal cortex2019
- Author(s)
  Daisuke Yamada, Jun-Ichiro Oka, Hiroshi Nagase, Akiyoshi Saitoh
- Organizer
  International Narcotics Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10286
[Presentation] A Selective agonist for δ-opioid receptors, KNT-127, but not SNC80, facilitates extinction learning of contextual fear memory in mice2019
- Author(s)
  Shoko Yanagisawa, Daisuke Yamada, Shinya Yanagita, Jun-ichiro Oka, Hiroshi Nagase, Akiyoshi Saitoh
- Organizer
  The 42nd Annual Meeting of the Japan Neuroscience Society, The 62nd Annual Meeting of the Japanese for Neurochemistry
- Data Source
  KAKENHI-PROJECT-17K10286
[Presentation] 多価不飽和脂肪酸バランスによる情動神経回路の修飾メカニズム2018
- Author(s)
  山田大輔、和田圭司、関口正幸
- Organizer
  下総薬理研究会
- Data Source
  KAKENHI-PROJECT-17K18402
[Presentation] 多価不飽和脂肪酸バランスによる情動神経回路の修飾メカニズム2018
- Author(s)
  山田大輔
- Organizer
  東京理科大学脳学際研究部門BIRD脳科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K18402
[Presentation] オピオイドδ受容体を標的とした向精神薬開発の可能性2017
- Author(s)
  斎藤顕宜、長瀬博、山田光彦
- Organizer
  第37回鎮痛薬・オピオイドペプチドシンポジウム
- Data Source
  KAKENHI-PROJECT-17K10286
[Presentation] 食中脂肪酸バランスによる情動制御とその神経メカニズム2016
- Author(s)
  山田大輔、関口正幸
- Organizer
  第134回日本薬理学会関東部会
- Place of Presentation
  栃木県大田原市・国際医療福祉大学
- Year and Date
  2016-07-09
- Invited
- Data Source
  KAKENHI-PROJECT-15K21653
[Presentation] 食中脂肪酸バランスによる情動制御とその神経メカニズム2016
- Author(s)
  山田大輔
- Organizer
  第134回日本薬理学会関東部会
- Place of Presentation
  国際医療福祉大学、栃木県大田原市
- Year and Date
  2016-07-09
- Invited
- Data Source
  KAKENHI-PROJECT-15K21653
[Presentation] Modulation of fear memory by dietary polyunsaturated fatty acids via cannabinoid receptors2015
- Author(s)
  山田大輔、和田圭司、関口正幸
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  兵庫県神戸市・神戸国際会議場
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-15K21653

1. Saitoh Akiyoshi (00366832)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
2. 山田美佐 (10384182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. 岡淳一郎 (40134613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 山田光彦 (60240040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 関口正幸 (80260339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 横堀将司 (70449271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐々木和馬 (30832266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 五十嵐豊 (50771101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山田真吏奈 (70508621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 布施明 (80238641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 阪本太吾 (90587073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YANAGITA Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹内絵理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamada Daisuke 山田 大輔

Research Projects

Research Products

Co-Researchers

末梢－中枢連環による情動変容におけるオピオイドδ受容体の機能解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マイクロ波びまん性脳損傷に対する病態可視化と集学的治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Region-specific regulation of anxiety and fear in the medial prefrontal cortex via delta-opioid receptors.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of regulatory mechanism of neural circuit of emotion regulation through delta-opioid receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the neural circuit mechanism of antidepressant-like effect of dietary polyunsaturated fatty acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of the anxiolytic-like effects induced by delta opioid receptor agonists using conditioned fear test in mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of underlying mechanism for the modulation of fear circuit by dietary polyunsaturated fatty acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ファルマシア52巻4号2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The delta opioid receptor agonist <scp>KNT</scp>‐127 relieves innate anxiety‐like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] δオピオイド受容体を介した情動行動制御とその神経メカニズム2022

Author(s)

Journal Title

Data Source

[Journal Article] 情動調節におけるδオピオイド受容体の役割とそのメカニズム2022

Author(s)

Journal Title

Data Source

[Journal Article] オピオイドの情動における役割 δ受容体を介した情動調節の分子・神経回路2022

Author(s)

Journal Title

Data Source

[Journal Article] Selective δ-opioid receptor agonist, KNT-127, facilitates contextual fear extinction via infralimbic cortex and amygdala in mice2022

Author(s)

Journal Title

Data Source

[Journal Article] Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice.2021

Author(s)

Journal Title

Data Source

[Journal Article] Are δ-Opioid Receptor Agonists with Facilitating Effects on Fear Extinction Learning Candidates for the Treatment of Post-Traumatic Stress Disorder?2021

Author(s)

Journal Title

Data Source

Yamada Daisuke 山田大輔