Higuchi Kei 樋口慧

… Alternative Names

樋口慧ヒグチケイ

HIGUCHI Kei 樋口慧

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Researcher Number	10625304
Other IDs
Affiliation (Current)	2023: 東京薬科大学, 薬学部, 講師 2023: 帝京大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2021: 東京薬科大学, 薬学部, 助教 2012 – 2018: 帝京大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator ヒポタウリン / 酸化ストレス / Slc6a13 / 細胞保護効果 / 抗アポトーシス / エズリン / 塩基性薬物 / オーファントランスポーター / 血液脳関門 / 薬物輸送 / オリゴペプチドトランスポーター / 促進拡散 / 小腸上皮細胞 … More Except Principal Investigator … More トランスポーター / 血液脳関門 / ヒト脳移行性 / ヒト血液脳関門モデル細胞 / 血液脳関門モデル細胞 / ヒト細胞株 / カチオン性薬物 / 脳移行性 / 遺伝子解析 / スケールアップ / ヒト由来不死化細胞株 / RNAiライブラリー / 遺伝子抑制 / 輸送特性 / 発現解析 / 有機カチオン性薬物 / 循環培養システム / フロー培養システム / オピオイド鎮痛薬 / オピオイド受容体 / オキシコドン / 脳微小透析法 / 有機カチオン輸送系 / 薬物認識性 / ヒト脳毛細血管モデル / ヒトiPS由来脳毛細血管内皮細胞 / プロトン-有機カチオン交換輸送系 / ヒトiPS細胞由来脳毛細血管内皮細胞 / ヒト不死化脳毛細血管内皮細胞 / 基質認識性 / 塩基性薬物 / ヒトiPS細胞 / 有機カチオン-プロトン交換輸送系 / 有機カチオントランスポーター / ヌクレオシド / 輸送 / 核酸 / 吸収 / 薬物動態 / 促進拡散 / 膜結合型mucin / 遺伝子編集 / 糖鎖 / 脂溶性抗がん剤 / 粘液層 / ゲノム編集 / 薬物吸収 Less

Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract
- Principal Investigator
  
  井上勝央
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
消化管の薬物吸収を制御する新規促進拡散型オリゴペプチドトランスポーターの分子同定Principal Investigator
- Principal Investigator
  
  樋口慧
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of the molecular mechanism of membrane-bound mucins in intestinal drug absorption.
- Principal Investigator
  
  岸本久直
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
塩基性薬物輸送を担う血液脳関門オーファントランスポーターの機能解明Principal Investigator
- Principal Investigator
  
  樋口慧
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Elucidation of the drug recognition properties and molecular entities of the organic cation-proton exchange system at the human blood-brain barrier
- Principal Investigator
  
  Deguchi Yoshiharu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Transport aross the blood-brain barrier in relation to CNS actions of opioid analgesics
- Principal Investigator
  
  Okura Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Development of a novel experimental evaluation method for predicting the drug delivery to the brain in human
- Principal Investigator
  
  DEGUCHI YOSHIHARU
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Mechanism of hypotaurine transport by Slc6a13 for oxidative stress defensePrincipal Investigator
- Principal Investigator
  
  HIGUCHI Kei
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University
Prediction of the human brain distribution for the central nervous system drugs using a novel human immortalized brain capillary endothelial cells
- Principal Investigator
  
  DEGUCHI Yoshiharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Teikyo University

All 2022 2021 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter2022
- Author(s)
  Higuchi K, Sugiyama K, Tomabechi R, Kishimoto H, Inoue K
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Issue: 4 Pages: 101800-101800
- DOI
  10.1016/j.jbc.2022.101800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06678
[Journal Article] Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.2018
- Author(s)
  Hiranaka S, Tega Y, Higuchi K, Kurosawa T, Deguchi Y, Arata M, Ito A, Yoshida M, Nagaoka Y, Sumiyoshi T.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 9(9) Issue: 9 Pages: 884-888
- DOI
  10.1021/acsmedchemlett.8b00099
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-16K08381, KAKENHI-PROJECT-19K07231, KAKENHI-PROJECT-26221204
[Journal Article] Expression and functional characterization of drug transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells.2018
- Author(s)
  4.Kurosawa T, Tega Y, Higuchi K, Yamaguchi T, Kawabata K, Nakakura T, Mochizuki T, Kusuhara H, Deguchi Y
- Journal Title
  
  Mol Pharm.
  
  Volume: 15 Issue: 12 Pages: 5546-5555
- DOI
  10.1021/acs.molpharmaceut.8b00697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18982, KAKENHI-PROJECT-16K08381
[Journal Article] Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells.2017
- Author(s)
  Kurosawa T, Higuchi K, Okura T, Kobayashi K, Kusuhara H, Deguchi Y.
- Journal Title
  
  J Pharm Sci.
  
  Volume: In press Issue: 9 Pages: 2576-2582
- DOI
  10.1016/j.xphs.2017.04.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08080, KAKENHI-PROJECT-16K08381
[Journal Article] Cocktail-dosing microdialysis study to simultaneously assess delivery of multiple organic-cationic drugs to the brain.2016
- Author(s)
  Atsushi Kitamura, Takashi Okura, Kei Higuchi, Yoshiharu Deguchi
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 105 Issue: 2 Pages: 935-940
- DOI
  10.1002/jps.24691
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08080, KAKENHI-PROJECT-25460199, KAKENHI-PROJECT-16K08381
[Journal Article] Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model2015
- Author(s)
  Higuchi K, Kitamura A, Okura T, Deguchi Y
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 30 Issue: 2 Pages: 182-187
- DOI
  10.1016/j.dmpk.2014.12.006
- NAID
  210000180315
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460199
[Journal Article] The Blood-Brain Barrier Transport Mechanism Controlling Analgesic Effects of Opioid Drugs in CNS2015
- Author(s)
  黄倉　崇、樋口　慧、出口芳春
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 135 Issue: 5 Pages: 697-702
- DOI
  10.1248/yakushi.14-00234-2
- NAID
  130005066918
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2015-05-01
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-15K08080, KAKENHI-PROJECT-25460199
[Journal Article] System amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.2014
- Author(s)
  Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi, K, Maruyama T, Tomi M, Nakashima E
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: VOL. 1838 Issue: 5 Pages: 1306-12
- DOI
  10.1016/j.bbamem.2014.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249076, KAKENHI-PROJECT-24390381, KAKENHI-PROJECT-24790171, KAKENHI-PROJECT-25462574, KAKENHI-PROJECT-25560063, KAKENHI-PROJECT-25670706, KAKENHI-PROJECT-25860396
[Journal Article] Proton-Coupled Organic Cation Antiporter-Mediated Uptake of Apomorphine Enantiomers in Human Brain Capillary Endothelial Cell Line hCMEC/D32014
- Author(s)
  Okura T, Higuchi K, Kitamura A, Deguchi Y
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 2 Pages: 286-291
- DOI
  10.1248/bpb.b13-00773
- NAID
  130003382121
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-25460199
[Journal Article] Transport characteristics of tramadol in the blood-brain barrier2014
- Author(s)
  Atsushi Kitamura, Kei Higuchi, Takashi Okura, Yoshiharu Deguchi
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 103 Issue: 10 Pages: 3335-3341
- DOI
  10.1002/jps.24129
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590213, KAKENHI-PROJECT-25460199
[Journal Article] Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion.2013
- Author(s)
  Nishimura T, Takanohashi T, Tomi M, Horikoshi M, Higuchi K, Sai Y, Nakashima E.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102(9) Issue: 9 Pages: 3356-3363
- DOI
  10.1002/jps.23551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790171, KAKENHI-PROJECT-25860396
[Journal Article] Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.2013
- Author(s)
  Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E.
- Journal Title
  
  J Pharm Sci
  
  Volume: 102 Issue: 9 Pages: 3364-3372
- DOI
  10.1002/jps.23549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590443, KAKENHI-PROJECT-23790199, KAKENHI-PROJECT-24790171, KAKENHI-PROJECT-25860396
[Presentation] MCT6/SLC16A5の細胞内局在の解析と内因性基質の探索2022
- Author(s)
  杉山滉基、樋口慧、志村優太、岸本久直、井上勝央
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] Identification of an endogenous substrate of MCT62021
- Author(s)
  Koki Sugiyama, Kei Higuchi, Yuta Shimura, Hisanao Kishimoto, Katsuhisa Inoue
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-21K06678
[Presentation] 気液界面を模倣する疎水性溶媒を用いた上皮系培養細胞における粘液産生と細胞形態への影響2021
- Author(s)
  鷹野遥、岸本久直、樋口慧、井上勝央
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21K06695
[Presentation] ヒトiPS細胞由来脳毛細血管内皮細胞におけるトランスポーターの機能的発現2018
- Author(s)
  8.手賀悠真、黒澤俊樹、樋口　慧、山口朋子、川端健二、出口芳春
- Organizer
  日本薬剤学会第33 年会（静岡）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門モデル細胞を用いたH+/有機カチオン交換輸送体の基質スクリーニング2018
- Author(s)
  1.手賀悠真，北村　敦，大町蕗子，黒澤俊樹，樋口慧，板垣文雄，出口芳春
- Organizer
  第３回トランスポーター研究会関東部会（千葉）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ゲノム編集ヒト血液脳関門細胞における薬物輸送機能評価2018
- Author(s)
  樋口　慧、手賀悠真、黒澤俊樹、濱弘太郎、横山和明、出口芳春
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-17K15521
[Presentation] Characterization of mesoridazine transport in human cerebral microvessel endothelial cells, hCMEC/D32018
- Author(s)
  6.Yasuyuki Debori1, Tomoko Igari, Masanori Nakakariya, Nobuyuki Amano, Yuma Tega, Kei Higuchi, Takashi Okura and Yoshiharu Deguchi
- Organizer
  第33JSSX第22MDO合同年会（金沢）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Investigation of SLC35F2 drug transport function in mouse brain and primate BBB models.2018
- Author(s)
  4.Tatsuki Mochizuki, Tadahaya Mizuno, Kei Higuchi, Yuma Tega, Toshiki Kurosawa, Tomoko Yamaguchi, Kenji Kawabata, Yoshiharu Deguchi, Hiroyuki Kusuhara
- Organizer
  第33JSSX第22MDO合同年会（金沢）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] 血液脳関門透過性を有するヒストン脱アセチル化酵素阻害剤の探索研究2018
- Author(s)
  2.住吉孝明，平中誠弥，手賀悠真，樋口慧，黒澤俊樹，出口芳春，本間光貴，新真由美，伊藤昭博，吉田稔，長岡康夫
- Organizer
  第36回メディシナルケミストリーシンポジウム（京都）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Screening of proton-coupled organic cation antiporter substrates using hCMEC/D3 cells: an in vitro human blood-brain barrier model2018
- Author(s)
  5.Atsushi Kitamura, Yuma Tega, Toshiki Kurosawa, Kei Higuchi, Yoshiharu Deguchi
- Organizer
  第33JSSX第22MDO合同年会（金沢）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ゲノム編集ヒト血液脳関門細胞における薬物輸送機能評価2018
- Author(s)
  7.樋口　慧、手賀悠真、黒澤俊樹、濱弘太郎、横山和明、出口芳春
- Organizer
  日本薬剤学会第33 年会（静岡）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] CRISPR-Cas9システムを用いたヒト血液脳関門細胞の排出輸送系ノックアウト2017
- Author(s)
  樋口　慧、手賀悠真、黒澤俊樹、濱弘太郎、横山和明、出口芳春
- Organizer
  日本薬学会第137年回（仙台）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Gene expression and　function of drug transporters in brain microvascular endothelial cells derived from human iPS cells2017
- Author(s)
  Toshiki Kurosawa, Yuma Tega, Kei Higuchi, Tomoko Yamaguchi, Kenji Kawabata, Yoshiharu Deguchi
- Organizer
  第32日本薬物動態学会年会（東京）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門プロトン/有機カチオンアンチポーターの機能制御因子の解析2017
- Author(s)
  樋口　慧、近藤麻美、上松祐貴、黒澤俊樹、黄倉　崇、出口芳春
- Organizer
  日本薬学会第137年回
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] ヒト血液脳関門プロトン/有機カチオンアンチポーターの機能制御因子の解析2017
- Author(s)
  〇樋口　慧、近藤麻美、上松祐貴、黒澤俊樹、黄倉　崇、出口芳春
- Organizer
  日本薬学会第137年会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] CRISPR-Cas9システムを用いたヒト血液脳関門細胞の2017
- Author(s)
  樋口　慧、手賀悠真、黒澤俊樹、濱弘太郎、横山和明、出口芳春
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15521
[Presentation] ヒトiPS由来脳毛細血管内皮細胞における薬物輸送能の解明2017
- Author(s)
  黒澤俊樹、手賀悠真、樋口　慧、山口朋子、川端健二、出口芳春
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム（金沢）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] H+/有機カチオン交換輸送体を標的としたHDAC阻害剤の脳へのデリバリー2017
- Author(s)
  手賀悠真、平中誠弥、樋口慧、出口芳春、伊藤昭博、吉田稔、長岡康夫、住吉孝明
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム（金沢）
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Transport characteristics of varenicline in the blood-brain barrier2016
- Author(s)
  Kurosawa T, Higuchi K, Okura T, Kusuhara H, Deguchi Y.
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  長野県松本市キッセイ文化ホール
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Transport characteristics of varenicline in the blood-brain barrier2016
- Author(s)
  Toshiki Kurosawa, Kei Higuchi, Takashi Okura, Hiroyuki Kusuhara, and Yoshiharu Deguchi
- Organizer
  第31日本薬物動態学会年会（松本）
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] 血液脳関門におけるバレニクリンの輸送解析2016
- Author(s)
  樋口　慧、黒澤俊樹、黄倉　崇、楠原洋之、出口芳春
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム（名古屋）
- Place of Presentation
  名古屋
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08381
[Presentation] Gene expression profiles in hCMEC/D3 cells with different transport activities of proton/organic cation antiporter2015
- Author(s)
  Higuchi K, Okura T, Uematsu Y, Kondo A, Ito H, Deguchi Y
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Histamine H1-receptor signaling in human blood-brain barrier cells2015
- Author(s)
  Okura T, Higuchi K, Ueno M, Ito H, Kondo A, Deguchi Y
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Analysis of gene expression profiles related to the transport activity of the proton/organic cation antiport system in hCMEC/D3 cells2015
- Author(s)
  Higuchi K, Okura T, Uematsu Y, Kondo A, Ito H, Deguchi Y
- Organizer
  Barcelona BioMed Conference, Blood Brain Barrier
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2015-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Histamine H1-receptor signaling in human blood-brain barrier cells2015
- Author(s)
  Takashi Okura, Kei Higuchi, Manami Ueno , Hironao Ito, Asami Kondo, Yoshiharu Deguchi
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Blood-to-brain transport of apomorphine enantiomers by proton-coupled organic cation antiporter at the blood-brain barrier2015
- Author(s)
  Okura T, Higuchi K, Kitamura A, Deguchi Y
- Organizer
  11th International Conference on Cerebral Vascular Biology
- Place of Presentation
  Paris (France)
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Blood-to-brain transport of apomorphine enantiomers by proton-coupled organic cation antiporter at the blood-brain barrier2015
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  11th Cerebral Vascular Biology International Conference
- Place of Presentation
  パリ
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Involvement of functionally diverse proton-coupled organic cation antiporter in blood-brain barrier transport of memantine2015
- Author(s)
  Higuchi K, Kitamura A, Okura T, Deguchi Y
- Organizer
  11th International Conference on Cerebral Vascular Biology
- Place of Presentation
  Paris (France)
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Memantine uptake mediated by a functionally diverse proton-coupled organic cation antiporter in human brain endothelial cells2015
- Author(s)
  Higuchi K, Okura T, Deguchi Y
- Organizer
  The Asian Federation for Pharmaceutical Sciences (AFPS) Conference 2015
- Place of Presentation
  Bangkok (Thailand)
- Year and Date
  2015-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Involvement of functionally diverse proton-coupled organic cation antiporter in blood-brain barrier transport of memantine2015
- Author(s)
  Kei Higuchi, Atsushi Kitamura, Takashi Okura, Yoshiharu Deguchi
- Organizer
  11th Cerebral Vascular Biology International Conference
- Place of Presentation
  パリ
- Year and Date
  2015-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] Gene expression profiles in hCMEC/D3 cells with different transport activities of proton/organic cation antiporter2015
- Author(s)
  Kei Higuchi, Takashi Okura, Yuki Uematsu, Asami Kondo, Hironao Ito, Yoshiharu Deguchi
- Organizer
  第30回日本薬物動態学会年会
- Place of Presentation
  東京（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08080
[Presentation] アポモルヒネの高い脳移行性を担う血液脳関門輸送のインビボ解析2014
- Author(s)
  黄倉　崇、佐藤樹夏、樋口　慧、北村　敦、柄谷礼人、久保敬史、小林俊生、櫻庭美菜子、出口芳春
- Organizer
  第58回薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] hCMEC/D3細胞を用いたカクテル法によるH+/有機カチオン交換輸送体基質探索の基礎的検討2014
- Author(s)
  樋口　慧、北村　敦、黄倉　崇、出口芳春
- Organizer
  日本薬学会第13４年会
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 脳マイクロダイアリシス法による薬物カクテルの脳移行性評価2014
- Author(s)
  北村敦、黒澤俊樹、樋口慧、黄倉崇、福島貴人、祖父江佳奈、出口芳春
- Organizer
  第58回薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Slc6a13を介した胎盤へのヒポタウリン供給が示す抗酸化作用.2013
- Author(s)
  杉田友紀、Mariam Duereh、樋口慧、西村友宏、崔吉道、登美斉俊、中島恵美.
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] ヒト血液脳関門細胞hCMEC/D3におけるメマンチンの輸送特性2013
- Author(s)
  樋口　慧、北村敦、黄倉　崇、出口芳春
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] Slc6a13を介した胎盤へのヒポタウリン供給が示す抗酸化作用2013
- Author(s)
  杉田友紀、Mariam Duereh、樋口慧、西村友宏、崔吉道、登美斉俊、中島恵美
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] ヒト血液脳関門におけるアポモルヒネのプロトン交換輸送機構2013
- Author(s)
  黄倉　崇、樋口慧、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインク愛知（名古屋）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] トランスポーターを利用した薬物の脳移行　－ヒト血液脳関門におけるメマンチンの輸送機構解析－2013
- Author(s)
  樋口　慧、黄倉　崇、出口芳春
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインク愛知（名古屋）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] EzrinがSlc6a13の細胞内局在および輸送機能に与える影響.2012
- Author(s)
  荒木光, 樋口慧, 西村友宏, 崔吉道, 登美斉俊, 中島恵美.
- Organizer
  第7回トランスポーター研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] ヒポタウリンのヒドロキシラジカル消去活性による胎盤細胞保護効果2012
- Author(s)
  Mariam Duereh、西村友宏、杉田友紀、樋口慧、登美斉俊、中島恵美
- Organizer
  日本動物実験代替法学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] ヒポウリタンによるヒドロキシラジカルからの胎盤細胞保護効果.2012
- Author(s)
  Mariam Duereh, 樋口慧, 杉田友紀, 西村友宏, 登美斉俊, 中島恵美.
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] ヒポウリタンによるヒドロキシラジカルからの胎盤細胞保護効果2012
- Author(s)
  Mariam Duereh,樋口慧,杉田友紀,西村友宏,登美斉俊,中島恵美
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] EzrinがSlc6a13の細胞内局在および輸送機能に与える影響2012
- Author(s)
  荒木光,樋口慧,西村友宏,崔吉道,登美斉俊,中島恵美
- Organizer
  第7回トランスポーター研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] Effect of ezrin on cellular localization and transport function of Slc6a13.2012
- Author(s)
  Araki H, Higuchi K, Nishimura T, Sai Y, Tomi M, Nakashima E.
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] ヒト脳毛細血管内皮細胞株hCMEC/D3を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉崇、下村慶太、樋口　慧、Pierre-Oliver Couraud、出口芳春
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] ヒポタウリンのヒドロキシラジカル消去活性による胎盤細胞保護効果.2012
- Author(s)
  Mariam Duereh、西村友宏、杉田友紀、樋口慧、登美斉俊、中島恵美.
- Organizer
  日本動物実験代替法学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] ヒト脳毛細血管内皮細胞株 hCMEC/D3 を用いたカチオン性薬物のヒト血液脳関門透過性予測の試み2012
- Author(s)
  黄倉崇、樋口慧、出口芳春ら
- Organizer
  日本動物実験代替学会第25回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590144
[Presentation] Effect of ezrin on cellular localization and transport function of Slc6a132012
- Author(s)
  Araki H, Higuchi K, Nishimura T, Sai Y, Tomi M, Nakashima E
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790171
[Presentation] A proton-coupled organic cation antiporter mediated transport of apomorphine in human brain capillary endothelial cell line hCMEC/D3
- Author(s)
  Takashi Okura, Kei Higuchi, Atsushi Kitamura, Yoshiharu Deguchi
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東北大学片平キャンパス(仙台）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] ヒト血液脳関門のトラマドール輸送における
- Author(s)
  北村　敦、樋口　慧、黄倉　崇、出口　芳春
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  帝京大学板橋キャンパス（東京）
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] IN VIVO AND IN VITRO TRANSPORT OF APOMORPHINE ENANTIOMERS ACROSS THE BLOOD-BRAIN BARRIER
- Author(s)
  Kitamura A, Higuchi K, Okura T, Deguchi Y
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] 脳マイクロダイアリシス法を用いたカクテル投与による薬物の脳移行性評価
- Author(s)
  北村敦、樋口慧、黄倉崇、祖父江佳奈、福島貴人、出口芳春
- Organizer
  日本薬剤学会第29年回
- Place of Presentation
  埼玉
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] プロトン交換輸送体によるアポモルヒネのヒト血液脳関門輸送
- Author(s)
  黄倉　崇、樋口　慧、北村敦、出口芳春
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀（東京
- Data Source
  KAKENHI-PROJECT-25460199
[Presentation] TRANSPORT CHARACTERISTICS OF TRAMADOL AT THE BLOOD-BRAIN BARRIER
- Author(s)
  Deguchi Y, Kitamura A, Higuchi K, Okura T
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460199

1. DEGUCHI Yoshiharu (40254255)

# of Collaborated Projects: 4 results

# of Collaborated Products: 44 results
2. OKURA Takashi (80326123)

# of Collaborated Projects: 4 results

# of Collaborated Products: 34 results
3. 井上勝央 (50315892)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. 岸本久直 (80723600)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. KATO Sayaka (70505940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HOSOYAMADA MAKOTO (00291659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 平田圭一 (80424852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中谷絵理子 (90803916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Kawabata Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. Yamaguchi Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. Kusuhara Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 丸山哲夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 飯笹久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 中倉敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higuchi Kei 樋口 慧

樋口 慧 ヒグチ ケイ

HIGUCHI Kei 樋口 慧

Research Projects

Research Products

Co-Researchers

Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract

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消化管の薬物吸収を制御する新規促進拡散型オリゴペプチドトランスポーターの分子同定Principal Investigator

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Evaluation of the molecular mechanism of membrane-bound mucins in intestinal drug absorption.

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塩基性薬物輸送を担う血液脳関門オーファントランスポーターの機能解明Principal Investigator

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Elucidation of the drug recognition properties and molecular entities of the organic cation-proton exchange system at the human blood-brain barrier

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Transport aross the blood-brain barrier in relation to CNS actions of opioid analgesics

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Development of a novel experimental evaluation method for predicting the drug delivery to the brain in human

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Mechanism of hypotaurine transport by Slc6a13 for oxidative stress defensePrincipal Investigator

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Prediction of the human brain distribution for the central nervous system drugs using a novel human immortalized brain capillary endothelial cells

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[Journal Article] Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter2022

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[Journal Article] Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.2018

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[Journal Article] Expression and functional characterization of drug transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells.2018

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[Journal Article] Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells.2017

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Higuchi Kei 樋口慧

樋口慧ヒグチケイ

HIGUCHI Kei 樋口慧