Takizawa Hitoshi 滝澤仁

Researcher Number	10630866
Other IDs
Affiliation (Current)	2025: 熊本大学, 国際先端医学研究機構, 特定事業教員(教授)
Affiliation (based on the past Project Information) *help	2017 – 2024: 熊本大学, 国際先端医学研究機構, 特別招聘教授 2015 – 2017: 熊本大学, 国際先端医学研究機構, 特別招聘准教授 2016: 熊本大学, 学内共同利用施設等, その他
Review Section/Research Field	Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54010:Hematology and medical oncology-related / Basic Section 54010:Hematology and medical oncology-related / Hematology / Biological Sciences / Hematology / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Basic Section 50010:Tumor biology-related / Hematology
Keywords	Principal Investigator 造血幹細胞 / 炎症 / クローナル造血 / 間葉系ストローマ細胞 / 骨髄ニッチ / 造血ニッチ / 赤血球造血 / inflammation / clonal hematopoiesis / Inflammation … More / Leukemia / Tracing / Lineage / Hematopoiesis / Clonal / 免疫記憶 / 自然免疫シグナル / 骨髄造血 / 遊走 / 老化 / 腸管炎症 / 造血前駆細胞 / 間葉系幹細胞 / ヒト化マウス、造血幹細胞、骨髄ニッチ、白血病 / 造血幹細胞ニッチ / ヒト化マウス / 移植・再生医療 / 造血幹細胞、炎症、感染 / 炎症ストレス / Toll-like receptor / 感染 … More Except Principal Investigator シングルセル / ゲノミクス / ゲノム編集 / ヒト患者腫瘍組織移植モデル / BCR-ABL1 / B前駆細胞型急性リンパ性白血病 / メタボロミクス / PDX / IKZF1 / BCP-ALL / リンパ腫 / 発がん機序 / 点突然変異 / がん遺伝子 / シグナル伝達 / B細胞 / 遺伝子変異 / 悪性リンパ腫 / 造血幹細胞 / 血液内科学 / 血液内科 Less

Understanding brain dysfunction caused by clonal hematopoiesisPrincipal Investigator
- Principal Investigator
  
  滝澤仁
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University
IKZF1変異によるB前駆細胞型急性リンパ性白血病悪性化の機序
- Principal Investigator
  
  吉田年美
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
造血幹細胞における自然免疫記憶の形成と維持Principal Investigator
- Principal Investigator
  
  滝澤仁
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
tRNA修飾異常を起点とした赤血球プロテオスタシスの破綻Principal Investigator
- Principal Investigator
  
  滝澤仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University
Mechanism underlying initiation of bone marrow hematopoiesis in neonatePrincipal Investigator
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Modulation of immune memory in blood stem cell toward effective host defensePrincipal Investigator
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University
Investigating the mechanisms of B cell lymphomagenesis driven by MYD88 and CD79B mutations
- Principal Investigator
  
  Horikawa Keisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Understanding of hematopoietic stem cell trafficking across developmental hematopoietic organsPrincipal Investigator
- Principal Investigator
  
  TAKIZAWA Hitoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Inflammation induced emergence and evolution of clonal hematopoiesisPrincipal Investigator
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kumamoto University
Role of inflammation in initiation and progression of clonal hematopoiesisHost Researcher
- Principal Investigator
  
  滝澤仁
- Host Researcher
  
  滝澤仁
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Mechanism of stem cell aging induced by inflammatory stressPrincipal Investigator
- Principal Investigator
  
  滝澤仁
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
understanding of leukemic niche signal to establish niche-targeting thearpyPrincipal Investigator
- Principal Investigator
  
  滝澤仁
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Reconstiution of functional artificail bone marrow niche via induction of mesenchymal stromal cell divisionPrincipal Investigator
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
炎症性因子による造血幹細胞老化のメカニズムPrincipal Investigator
- Principal Investigator
  
  滝澤仁
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Analysis of normal and malignant hematopoietic niche using nove bone marrow humanized micePrincipal Investigator
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
Induction of self-renewal in single hematopoietic stem cells
- Principal Investigator
  
  Ema Hideo
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kumamoto University
  Keio University

All 2023 2022 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 炎症に対する造血幹細胞応答2016
- Author(s)
  滝澤　仁
- Publisher
  日本血液学会　臨床血液
- Data Source
  KAKENHI-PUBLICLY-15H01519
[Book] Humanized Mice for HIV Research2015
- Author(s)
  Kovtonyuk LV, Takizawa H.
- Total Pages
  538
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15H05669
[Journal Article] Inflammation Regulates Haematopoietic Stem Cells and Their Niche2022
- Author(s)
  Ho Nicole Pui-Yu、Takizawa Hitoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1125-1125
- DOI
  10.3390/ijms23031125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21KK0150
[Journal Article] Hlf expression marks the developmental pathway for hematopoietic stem cells but not for erythroid-myeloid progenitors2019
- Author(s)
  Yokomizo T*, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T
- Journal Title
  
  J Exp Med
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02843
[Journal Article] Development of the Hematopoietic System: Role of Inflammatory Factors2019
- Author(s)
  Hayashi Y#, Sezaki M#, Takizawa H*
- Journal Title
  
  Wiley Interdiscip Rev Dev Biol
  
  Volume: 27 Issue: 4
- DOI
  10.1002/wdev.341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05651, KAKENHI-PROJECT-18H02843, KAKENHI-PROJECT-18J20690, KAKENHI-PROJECT-18K16091
[Journal Article] 炎症と造血”Inflammation and early hematopoiesis2018
- Author(s)
  滝澤仁、林慶和
- Journal Title
  
  臨床血液
  
  Volume: 59 Pages: 1955-1961
- Data Source
  KAKENHI-PUBLICLY-17H05651
[Journal Article] Engineered humanized bone organs maintain human hematopoiesis in vivo2018
- Author(s)
  Kristin Fritsch; Sebastien;bastien Pigeot; Xiaomin Feng; Paul E Bourgine; Timm Schroeder; Ivan Martin; Markus Manz; Hitoshi Takizawa
- Journal Title
  
  Experimental Hematology
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17F17424
[Journal Article] Engineered humanized bone organs maintain human hematopoiesis in vivo,2018
- Author(s)
  1.Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H
- Journal Title
  
  Experimental Hematology
  
  Volume: 61 Pages: 45-51.e5
- DOI
  10.1016/j.exphem.2018.01.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05669, KAKENHI-PROJECT-16K15504
[Journal Article] Inflamm-Aging of hematopoiesis, hematopoietic stem cells, bone marrow microenvironment.2016
- Author(s)
  Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 502-502
- DOI
  10.3389/fimmu.2016.00502
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01519
[Journal Article] Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo.2016
- Author(s)
  Kovtonyuk LV, Markus G. Manz, Takizawa H
- Journal Title
  
  Blood
  
  Volume: ０ Pages: 0-0
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01519
[Presentation] Erythroblast differentiation driven by mitochondrial translation2023
- Author(s)
  Hitoshi Takizawa
- Organizer
  Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] Terminal erythroid differentiation is regulated by mitochondrial translation via maintenance of iron homeostasis2022
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
- Organizer
  The 64th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] Mitochondrial tRNA modification regulates erythroid differentiation by maintaining iron homeostasis2022
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
- Organizer
  The 84th Annual Meeting of Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] Innate Immune Signal-Regulated Hematopoiesis2019
- Author(s)
  Hitoshi Takizawa
- Organizer
  61st ASH annual meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19520
[Presentation] Microbial signal instructs early hematopoiesis upon intestinal tissue damage2019
- Author(s)
  Yoshikazu Hayashi, Maiko Sezaki, Sumit Sheoran, Tatsuya Morishima1, Gaku Nakato, Shinji Fukuda, Hitoshi Takizawa
- Organizer
  48th Annual Scientific Meeting of International Society of Experimental Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19520
[Presentation] EARLY HEMATOPOIESIS TRANSLATES MICROBIAL SIGNALS TO INTESTINAL TISSUE REPAIR2019
- Author(s)
  Hitoshi Takizawa
- Organizer
  24th Congress of European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19520
[Presentation] Taurine Modification of Mitochondrial tRNAs is Indispensable for Fetal Erythroid Differentiation2019
- Author(s)
  Md. Fakruddin, Hitoshi Takizawa
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18F18408
[Presentation] Engineered human bone organ maintains hematopoietic stem cell and hematopoiesis2018
- Author(s)
  Hitoshi Takizawa
- Organizer
  JSPS-NUS joint symposium
- Invited
- Data Source
  KAKENHI-PROJECT-15H05669
[Presentation] CyTof-driven discovery for hematopoietic stem cell biology2018
- Author(s)
  Hitoshi Takizawa
- Organizer
  CyTOF User Meeting
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05651
[Presentation] 炎症と造血制御(Inflammation and hematopoietic regulation)2018
- Author(s)
  Hitoshi Takizawa
- Organizer
  The 80th Annual Meeting of the Japanese Society of Hematology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05651
[Presentation] Gut inflammatory stress impacts early hematopoiesis2018
- Author(s)
  Yoshikazu Hayashi and Hitoshi Takizawa
- Organizer
  JSPS-NUS joint symposium
- Data Source
  KAKENHI-PUBLICLY-17H05651
[Presentation] 感染における造血制御とその機能変容2018
- Author(s)
  Hitoshi Takizawa
- Organizer
  The 36th Annual Meeting of The Japanese Society for Bone and Mineral Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05651
[Presentation] Humanization of bone marrow niche for better maintenance of human hematopoiesis in xenograft model2017
- Author(s)
  Xiaomin Feng1 Kristin Fritsch, Sebastien Pigeot, Yuichiro Arima, Koichi Nishiyama, Ivan Martin, Markus G. Manz, Hitoshi Takizawa
- Organizer
  Japanese society of hematology
- Data Source
  KAKENHI-PROJECT-16K15504
[Presentation] Humanization of bone marrow niche for better maintenance of human hematopoiesis in xenograft model2017
- Author(s)
  Xiaomin Feng, Kristin Fritsch, Sebastien Pigeot, Yuichiro Arima, Koichi Nishiyama, Ivan Martin, Markus G. Manz, Hitoshi Takizawa
- Organizer
  Japanese society of hematology
- Data Source
  KAKENHI-PROJECT-15H05669
[Presentation] Impact of inflammatory stress on early hematopoiesis2017
- Author(s)
  Yoshikazu Hayashi and Hitoshi Takizawa
- Organizer
  Japanese soceity for immunology
- Data Source
  KAKENHI-PUBLICLY-17H05651
[Presentation] Humanization of bone marrow niche for better maintenance of human hematopoiesis in xenograft model2017
- Author(s)
  Xiaomin Feng, Kristin Fritsch, Sebastien Pigeot, Yuichiro Arima, Koichi Nishiyama, Ivan Martin, Markus G. Manz, Hitoshi Takizawa
- Organizer
  日本血液学会
- Place of Presentation
  東京
- Year and Date
  2017-10-20
- Data Source
  KAKENHI-PROJECT-17F17424
[Presentation] Impact of Inflammation in Hematopoietic Stem Cell Behavior2016
- Author(s)
  Hitoshi Takizawa
- Organizer
  JSPS-NUS symposium
- Place of Presentation
  Singapore
- Year and Date
  2016-01-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01519
[Presentation] Hematopoietic Stem Cell Response to Inflammation2015
- Author(s)
  Hitoshi Takizawa
- Organizer
  77th Annual Meeting of Japanese Society of Hematology
- Place of Presentation
  Kanazawa, Japan
- Year and Date
  2015-11-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01519
[Presentation] its HDirect Activation of TLR4-TRIF-ROS-p38 Pathways Limematopoietic Stem Cell Fitness2015
- Author(s)
  Hitoshi Takizawa
- Organizer
  13th Stem Cell Symposium
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2015-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01519

1. FAKRUDDIN MD.

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. Ema Hideo (50344445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Fumio Arai (90365403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ryuji Yokokawa (10411216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Horikawa Keisuke (60313095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 黒滝大翼 (10568455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 波江野洋 (70706754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HO Pui・Yu (40888385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 山下真幸 (80588038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 河合麻友 (50942687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 吉田年美 (80639154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FAKRUDDIN MD (20816475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 山下貴之 (40466321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森嶋達也 (40421375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 増田豪 (70383940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. FENG XIAOMIN

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. HO PUI YU

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takizawa Hitoshi 滝澤 仁

Research Projects

Research Products

Co-Researchers

Understanding brain dysfunction caused by clonal hematopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IKZF1変異によるB前駆細胞型急性リンパ性白血病悪性化の機序

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

造血幹細胞における自然免疫記憶の形成と維持Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

tRNA修飾異常を起点とした赤血球プロテオスタシスの破綻Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism underlying initiation of bone marrow hematopoiesis in neonatePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modulation of immune memory in blood stem cell toward effective host defensePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating the mechanisms of B cell lymphomagenesis driven by MYD88 and CD79B mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of hematopoietic stem cell trafficking across developmental hematopoietic organsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inflammation induced emergence and evolution of clonal hematopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of inflammation in initiation and progression of clonal hematopoiesisHost Researcher

Principal Investigator

Host Researcher

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of stem cell aging induced by inflammatory stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

understanding of leukemic niche signal to establish niche-targeting thearpyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reconstiution of functional artificail bone marrow niche via induction of mesenchymal stromal cell divisionPrincipal Investigator

Principal Investigator

Project Period (FY)

Takizawa Hitoshi 滝澤仁