MORISHIMA TATSUYA 森嶋達也

… Alternative Names

Morishima Tatsuya 森嶋達也

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Researcher Number	40421375
Other IDs	https://orcid.org/0000-0003-3876-3217
Affiliation (Current)	2026: 国際医療福祉大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2026: 熊本大学, 国際先端医学研究機構, 特任講師 2022 – 2024: 熊本大学, 国際先端医学研究機構, 特任講師 2019 – 2021: 熊本大学, 国際先端医学研究機構, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 抗炎症薬 / ドラッグ・リポジショニング / 脂肪酸代謝 / 薬剤耐性 / IDH遺伝子変異 / 急性骨髄性白血病 / T-ALL / タンパク質アセチル化 / 造血幹細胞 / 代謝 … More / Sirtuin / NAMPT / NAD+ / LMO2 / アセチル化 / 白血病 … More Except Principal Investigator 赤血球造血 / 鉄 / ミトコンドリア / 赤芽球 Less

tRNA修飾異常による加齢性造血器疾患発症機序の解明Principal Investigator
- Principal Investigator
  
  森嶋達也
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Red cell proteostasis dirupted by dysregulation of tRNA modification
- Principal Investigator
  
  Takizawa Hitoshi
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University
Elucidation of leukemia clone survival mechanism via lipid metabolic adaptationPrincipal Investigator
- Principal Investigator
  
  Morishima Tatsuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University
Development of novel therapy for leukemia targeting metabolism-dependent protein modificationPrincipal Investigator
- Principal Investigator
  
  Morishima Tatsuya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kumamoto University

All 2025 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis2025
- Author(s)
  Morishima, T., Fakruddin, M., Kanamori, Y., Masuda, T., Ogawa, A., Wang, Y., Schoonenberg, V. A. C., Butter, F., Arima, Y., Akaike, T., Moroishi, T., Tomizawa, K., Suda, T., Wei, F. Y., & Takizawa, H.
- Journal Title
  
  Science advances
  
  Volume: 11 Issue: 8 Pages: 1-17
- DOI
  10.1126/sciadv.adu3011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05265, KAKENHI-PUBLICLY-24H01292, KAKENHI-PROJECT-24H00065, KAKENHI-PROJECT-23K23867, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-22K19548, KAKENHI-PROJECT-23K20040
[Journal Article] GPRC5C drives branched-chain amino acid metabolism in leukemogenesis2023
- Author(s)
  Zhang YW, ... , Morishima T, ... , Cabezas-Wallscheid N.
- Journal Title
  
  Blood Advances
  
  Volume: 7 Issue: 24 Pages: 7525-7538
- DOI
  10.1182/bloodadvances.2023010460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Journal Article] Humanized mouse models with endogenously developed human natural killer cells for in?vivo immunogenicity testing of HLA class I-edited iPSC-derived cells2023
- Author(s)
  Flahou Charlotte、Morishima Tatsuya、Higashi Natsumi、Hayashi Yoshikazu、Xu Huaigeng、Wang Bo、Zhang Chaoqi、Ninomiya Atsushi、Qiu Wei-Yin、Yuzuriha Akinori、Suzuki Daisuke、Nakamura Sou、Manz Markus、Kaneko Shin、Hotta Akitsu、Takizawa Hitoshi、Eto Koji、Sugimoto Naoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 662 Pages: 76-83
- DOI
  10.1016/j.bbrc.2023.04.067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18299, KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-21K08413, KAKENHI-PROJECT-21H05047
[Journal Article] Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL‐1R/TLR signals2023
- Author(s)
  Wang Yuxin、Morishima Tatsuya、Sezaki Maiko、Sato Ryo、Nakato Gaku、Fukuda Shinji、Kobiyama Kouji、Ishii Ken J、Li Yuhua、Takizawa Hitoshi
- Journal Title
  
  EMBO reports
  
  Volume: 24 Issue: 12
- DOI
  10.15252/embr.202357485
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Journal Article] Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells2023
- Author(s)
  Morishima Tatsuya、Takahashi Koichi、Chin Desmond Wai Loon、Wang Yuxin、Tokunaga Kenji、Arima Yuichiro、Matsuoka Masao、Suda Toshio、Takizawa Hitoshi
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 1 Pages: 197-210
- DOI
  10.1111/cas.15994
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Journal Article] Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans.2022
- Author(s)
  Mende N, Bastos HP, Santoro A, Mahbubani KT, Ciaurro V, Calderbank EF, Quiroga Londono M, Sham K, Mantica G, Morishima T, Mitchell E, Lidonnici MR, Meier-Abt F, Hayler D, Jardine L, Curd A, Haniffa M, Ferrari G, Takizawa H, Wilson NK, Gottgens B, Saeb-Parsy K, Frontini M, Laurenti E.
- Journal Title
  
  Blood
  
  Volume: - Issue: 23 Pages: 3387-3401
- DOI
  10.1182/blood.2021013450
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Journal Article] Hematopoietic stem and progenitor cells integrate microbial signals to promote post‐inflammation gut tissue repair2022
- Author(s)
  Sezaki Maiko、Hayashi Yoshikazu、Nakato Gaku、Wang Yuxin、Nakata Sayuri、Biswas Subinoy、Morishima Tatsuya、Fakruddin Md、Moon Jieun、Ahn Soyeon、Kim Pilhan、Miyamoto Yuji、Baba Hideo、Fukuda Shinji、Takizawa Hitoshi
- Journal Title
  
  The EMBO Journal
  
  Volume: 41 Issue: 22
- DOI
  10.15252/embj.2022110712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-20K17381
[Journal Article] Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity.2021
- Author(s)
  Flahou C, Morishima T, Takizawa H, Sugimoto N.
- Journal Title
  
  Front Immunol
  
  Volume: 12 Pages: 662360-662360
- DOI
  10.3389/fimmu.2021.662360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-21K08413
[Journal Article] NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells2021
- Author(s)
  Xu Yun、Nasri Masoud、Dannenmann Benjamin、Mir Perihan、Zahabi Azadeh、Welte Karl、Morishima Tatsuya*#、Skokowa Julia*#. (*corresponding authors; #equally contribution)
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: 12 Issue: 1
- DOI
  10.1186/s13287-021-02144-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17833
[Journal Article] iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.2021
- Author(s)
  Dannenmann B, Klimiankou M, Oswald B, Solovyeva A, Mardan J, Nasri M, Ritter M, Zahabi A, Arreba-Tutusaus P, Mir P, Stein F, Kandabarau S, Lachmann N, Moritz T, Morishima T, Konantz M, Lengerke C, Ripperger T, Steinemann D, Erlacher M, Niemeyer CM, Zeidler C, Welte K, Skokowa J.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 28(5) Issue: 5 Pages: 906-922
- DOI
  10.1016/j.stem.2021.03.023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Journal Article] Genetic fingerprint defines hematopoietic stem cell pool size and function.2020
- Author(s)
  Morishima T*, Takizawa H*.(*corresponding authors)
- Journal Title
  
  Haematologica
  
  Volume: 105(3) Issue: 3 Pages: 526-528
- DOI
  10.3324/haematol.2019.241299
- Open Access
- Data Source
  KAKENHI-PROJECT-19K17833
[Journal Article] LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.2019
- Author(s)
  Morishima T*, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Haehnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Mueller P, Bajoghli B, Skokowa J*. (*corresponding authors)
- Journal Title
  
  Blood
  
  Volume: 134(14) Issue: 14 Pages: 1159-1175
- DOI
  10.1182/blood.2019000095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17833
[Presentation] tRNA 修飾による造血制御2024
- Author(s)
  森嶋達也
- Organizer
  エピトランスクリプトーム制御の分子機構と生理機能
- Invited
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] Establishing a novel culture system for lymphoid-biased human HSC induction.2024
- Author(s)
  Wang Y, Morishima T, Khalilnezhad A, Suda T, Takizawa H.
- Organizer
  The Keystone Hematopoiesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Mitochondrial translation regulates fetal erythropoiesis through regulation of iron homeostasis.2024
- Author(s)
  Morishima T, Fakruddin M, Masuda T, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Akaike T, Tomizawa K, Wei FY, Suda T, Takizawa H.
- Organizer
  The Keystone Hematopoiesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] tRNA 修飾による造血制御2024
- Author(s)
  森嶋　達也
- Organizer
  遺伝研研究会「エピトランスクリプトーム制御の分子機構と生理機能」
- Invited
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] ミトコンドリアtRNA修飾による赤血球分化制御2023
- Author(s)
  森嶋達也
- Organizer
  赤血球研究シンポジウム-基礎から応用へ
- Invited
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] Erythroid differentiation is mediated by mitochondrial translation and its regulation of iron homeostasis2023
- Author(s)
  Morishima T, Fakruddin M, Masuda T, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Tomizawa K, Wei FY, Suda T, Takizawa H
- Organizer
  Lund Stem Cell Center 20th Anniversary Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] ミトコンドリアtRNA修飾による赤血球分化制御2023
- Author(s)
  森嶋　達也
- Organizer
  赤血球研究シンポジウム-基礎から応用へ-
- Invited
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Erythroid differentiation is mediated by mitochondrial translation and its regulation of iron homeostasis.2023
- Author(s)
  Morishima T, Fakruddin M, Masuda T, Wang Y, Schoonenberg VAC, Butter F, Arima Y, Tomizawa K, Wei FY, Suda T, Takizawa H.
- Organizer
  Lund Stem Cell Center 20th Anniversary Conference.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Terminal erythroid differentiation is mediated by mitochondrial translation through regulation of iron homeostasis2023
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
- Organizer
  第20回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Terminal erythroid differentiation is regulated by mitochondrial translation via maintenance of iron homeostasis2022
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
- Organizer
  The 64th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] Mitochondrial tRNA modification regulates erythroid differentiation via maintenance of intracellular iron homeostasis2022
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
- Organizer
  The 51st Annual Scientific Meeting of International Society for Experimental Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] ミトコンドリアtRNA修飾による細胞内鉄動態を介した赤血球分化制御2022
- Author(s)
  森嶋　達也、Md. Fakruddin、増田　豪、Yuxin Wang、Vivien A. C. Schoonenberg、Falk Butter、有馬　勇一郎、富澤　一仁、Fan-Yan Wei、須田　年生、滝澤　仁
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Oncometabolite-independent anti-apoptotic feature via phospholipid metabolic adaptation in IDH2 mutant AML cells2022
- Author(s)
  Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa
- Organizer
  The 64th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Mitochondrial tRNA modification regulates erythroid differentiation by maintaining iron homeostasis2022
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
- Organizer
  The 84th Annual Meeting of Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-22K19548
[Presentation] Mitochondrial tRNA modification regulates terminal erythroid differentiation2022
- Author(s)
  Tatsuya Morishima
- Organizer
  The 5th KU-KAIST Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Terminal erythroid differentiation is regulated by mitochondrial translation via maintenance of iron homeostasis2022
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
- Organizer
  The 64th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] 脂肪酸代謝適応を介したIDH2変異AML細胞のアポトーシス耐性獲得2021
- Author(s)
  森嶋達也, 高橋康一, Desmond Chin, 徳永賢治, 松岡雅雄, 須田年生, 滝澤仁
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] Taurine modification of mitochondrial tRNAs regulates fetal erythropoiesis via ER stress response2021
- Author(s)
  Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Vivien Schoonenberg, Falk Butter, Yuichiro Arima, Kenichi Tsujita, Fan-Yan Wei, Hitoshi Takizawa
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] 脂質代謝適応獲得によるIDH変異白血病の生存メカニズムの解明2021
- Author(s)
  森嶋達也, Desmond Chin, 高橋康一,徳永賢治, 松岡雅雄, 須田年生, 滝澤仁
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K17833
[Presentation] Phospholipid metabolism adaptation induces drug resistance in IDH mutant AML cells2021
- Author(s)
  Tatsuya Morishima, Koichi Takahashi, Desmond Chin, Kenji Tokunaga, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa
- Organizer
  第18回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-21K08397
[Presentation] アラキドン酸低下を介したIDH関連オンコメタボライト非依存性AML細胞増殖2020
- Author(s)
  森嶋達也, Desmond Chin, 高橋康一, 有田　誠，徳永賢治, 松岡雅雄, 須田年生, 滝澤仁
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17833
[Presentation] 正常および悪性造血における代謝制御の解析2019
- Author(s)
  森嶋達也高橋康一, 徳永賢治, 松岡雅雄, 須田年生, 滝澤仁
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17833
[Presentation] LMO2 activation by NAMPT-NAD+-SIRT2 pathway mediated deacetylation is indispensable for early hematopoiesis and T-ALL leukemogenesis2019
- Author(s)
  Morishima T, Krahl AC, Xu Y, Aghaallaei N, Nasri M, Klimiankou M, Ritter M, Hartmann MD, Findik B, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Haehnel K, Hermanutz-Klein U, Kanz L, Bajoghli B, Andre M, Mueller P, Welte K, Skokowa J
- Organizer
  第17回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-19K17833

1. Takizawa Hitoshi (10630866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 増田豪 (70383940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 増田真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 魏范研

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MORISHIMA TATSUYA 森嶋 達也

Morishima Tatsuya 森嶋 達也

Research Projects

Research Products

Co-Researchers

tRNA修飾異常による加齢性造血器疾患発症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Red cell proteostasis dirupted by dysregulation of tRNA modification

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of leukemia clone survival mechanism via lipid metabolic adaptationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapy for leukemia targeting metabolism-dependent protein modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GPRC5C drives branched-chain amino acid metabolism in leukemogenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Humanized mouse models with endogenously developed human natural killer cells for in?vivo immunogenicity testing of HLA class I-edited iPSC-derived cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL‐1R/TLR signals2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hematopoietic stem and progenitor cells integrate microbial signals to promote post‐inflammation gut tissue repair2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic fingerprint defines hematopoietic stem cell pool size and function.2020

MORISHIMA TATSUYA 森嶋達也

Morishima Tatsuya 森嶋達也