Maehara Takashi 前原隆

… Alternative Names

MAEHARA TAKASHI 前原隆

前原隆マエハラタカシ

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Researcher Number	10637333
Other IDs
Affiliation (Current)	2025: 九州大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 九州大学, 大学病院, 講師 2023: 九州大学, 歯学研究院, 講師 2018 – 2023: 九州大学, 歯学研究院, 助教 2015: 九州大学, 歯学研究科(研究院), 助教 2014: 九州大学, 歯学研究科(研究院), 助教授
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Medium-sized Section 57:Oral science and related fields / Basic Section 57020:Oral pathobiological science-related / Surgical dentistry Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator B細胞 / T細胞 / IgG4関連疾患 / IgG4-RD / CD4+CTL / 自己免疫疾患 / シェーグレン症候群 / B / クラススイッチ / Tfh … More / 異所性胚中心 / 疲労T細胞 / エンハンサーRNA / 細胞傷害性T細胞 / 臓器線維化 / スイッチ遺伝子 / Tfr / T 細胞 / 免疫グロブリン / CD4+ / 線維芽細胞 / Bリンパ球 / Tリンパ球 / CD8+CTL / 細胞障害性T細胞 / マクロファージ / 線維化 / 全身性強皮症 / サイトカイン / CD4+T細胞 / 遺伝子解析 / T / IgE / アレルギー / Type 2 / 木村病 / IgG4 / IL10 / 論文報告 / 国際研究者交流（米国） / TFH / IgG4-DS … More Except Principal Investigator 口腔扁平上皮癌 / T細胞 / IgG4関連疾患 / 難治性がん / 治療抵抗性 / 制御性T細胞 / シングルセル / エンハンサーRNA / シングルセルRNA / 口腔扁平苔癬 / 疾患モデルマウス / 病因 / IgG4疾患モデルマウス / IgG4産生B細胞 / T細胞サブセット / TLR7 / マクロファージ / B細胞 / 唾液 / 診断 / バイオマーカー Less

細胞傷害性T細胞と相互連関する特異なB細胞同定の為の国際共同研究Principal Investigator
- Principal Investigator
  
  前原隆
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
IgG4関連疾患に特異な細胞傷害性T細胞の活性化経路の全容解明Principal Investigator
- Principal Investigator
  
  前原隆
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Kyushu University
難治性癌の悪性形質獲得に関わる特異な制御性T細胞サブセットの同定とその活性化機構
- Principal Investigator
  
  川野真太郎
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
口腔扁平苔癬の創薬ターゲットの探索～病因T細胞と関連エンハンサーRNAの同定～
- Principal Investigator
  
  中村誠司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
IgG4関連疾患の異所性胚中心オルガノイドから病因解明と新規モデル動物の樹立Principal Investigator
- Principal Investigator
  
  前原隆
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
IgG4関連疾患の創薬ターゲットとなり得る病因関連エンハンサーRNAの探索Principal Investigator
- Principal Investigator
  
  前原隆
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Immunologic specificity based pathogenesis of IgG4-related diseases and validation in mouse models of the disease
- Principal Investigator
  
  Nakamura Seiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
唾液中の可溶性マーカーに着目したIgG4関連疾患の新たな診断方法の開発
- Principal Investigator
  
  中村誠司
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Elucidation of the mechanisms of orang fibrosis using patients with IgG4-related disease and their mouse modelsPrincipal Investigator
- Principal Investigator
  
  Maehara Takashi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
New therapy targets for IgG4-RD and other human autoimmune disease focused on clonal expanded T and B cells.Principal Investigator
- Principal Investigator
  
  MAEHARA TAKASHI
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
IgG4関連疾患の病態解明に向けた免疫学的研究―異所性胚中心形成とTh細胞―Principal Investigator
- Principal Investigator
  
  前原隆
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018 2015

All Journal Article Presentation Book

[Book] B細胞とT細胞から紐解くIgG4関連疾患の病態形成メカニズム2024
- Author(s)
  坂本瑞樹、金子直樹、森山雅文、前原　隆、中村誠司
- Total Pages
  7
- Publisher
  臨床と病理
- Data Source
  KAKENHI-PROJECT-22K18401
[Book] IgG4関連疾患と木村病における疾患特異的な濾胞性Ｔ細胞.2023
- Author(s)
  前原　隆、宗村龍祐、古賀　理紗子、中村誠司
- Total Pages
  8
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-22K18401
[Book] IgG4 関連疾患と木村病における疾患特異的な濾胞性T細胞2023
- Author(s)
  前原隆、宗村龍祐、古賀理紗子、中村誠司
- Total Pages
  9
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-20H00553
[Book] Cytotoxic T cell2022
- Author(s)
  前原隆、古賀理紗子、中村誠司
- Total Pages
  2
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-20H00553
[Book] IgG4関連疾患の代替療法2020
- Author(s)
  前原隆、中村誠司
- Total Pages
  5
- Publisher
  Current Therapy
- Data Source
  KAKENHI-PROJECT-18KK0260
[Book] 新規疾患概念；IgG4関連疾患の免疫学的特徴から臓器線維化と炎症の病態解明へ向けて2020
- Author(s)
  前原隆、宗村龍祐、村上祐香、中村誠司
- Total Pages
  4
- Publisher
  アレルギーの臨床
- Data Source
  KAKENHI-PROJECT-18KK0260
[Book] IgG4関連疾患の代替療法2020
- Author(s)
  前原隆、中村誠司
- Total Pages
  5
- Publisher
  Current Therapy
- Data Source
  KAKENHI-PROJECT-19H03854
[Book] IgG4関連疾患の病態2020
- Author(s)
  前原隆、宗村龍祐、村上祐香、中村誠司
- Total Pages
  4
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-19H03854
[Book] 新規疾患概念；IgG4関連疾患の免疫学的特徴から臓器線維化と炎症の病態解明へ向けて2020
- Author(s)
  前原隆、宗村龍祐、村上祐香、中村誠司
- Total Pages
  4
- Publisher
  アレルギーの臨床
- Data Source
  KAKENHI-PROJECT-19H03854
[Book] IgG4関連疾患の病態2020
- Author(s)
  前原隆、宗村龍祐、村上祐香、中村誠司
- Total Pages
  4
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-18KK0260
[Journal Article] Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease2024
- Author(s)
  Koga Risako、Maehara Takashi、Aoyagi Ryuichi、Munemura Ryusuke、Murakami Yuka、Doi Atsushi、Kono Michihito、Yamamoto Hidetaka、Niiro Hiroaki、Kiyoshima Tamotsu、Tanabe Mika、Nakano Toshiaki、Matsukuma Yuta、Kawano Mitsuhiro、Stone John H.、Pillai Shiv、Nakamura Seiji、Kawano Shintaro
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 153 Issue: 4 Pages: 1095-1112
- DOI
  10.1016/j.jaci.2023.11.916
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18401, KAKENHI-PROJECT-21K19607
[Journal Article] Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD2024
- Author(s)
  Aoyagi Ryuichi、Maehara Takashi、Koga Risako、Munemura Ryusuke、Tomonaga Tadashi、Murakami Yuka、Doi Atsushi、Yamamoto Hidetaka、Kiyoshima Tamotsu、Kawano Shintaro、Nakamura Seiji
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 153 Issue: 2 Pages: 513-520.e10
- DOI
  10.1016/j.jaci.2023.08.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18401, KAKENHI-PROJECT-21K19607, KAKENHI-PROJECT-23K24549
[Journal Article] Extrafollicular IgD?CD27?CXCR5?CD11c? DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-192023
- Author(s)
  Allard-Chamard H、Kaneko N、Bertocchi A、Sun N、Boucau J、Kuo H、Farmer JR.、Perugino C、Mahajan VS.、Murphy SJ.H.、Premo K、Diefenbach T、Ghebremichael M、Yuen G、Kotta A、Akman Z、Lichterfeld M、Walker BD.、Yu XG.、Moriyama M、Maehara T、Nakamura S、Stone JH.、Padera RF.、Pillai S
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 6 Pages: 112630-112630
- DOI
  10.1016/j.celrep.2023.112630
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18401, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-21K19607, KAKENHI-PROJECT-22K19631, KAKENHI-PROJECT-21KK0163, KAKENHI-PROJECT-23KK0164, KAKENHI-PROJECT-23K24548
[Journal Article] Immune dysregulation in immunoglobulin G4 related disease2023
- Author(s)
  Maehara Takashi、Koga Risako、Nakamura Seiji
- Journal Title
  
  Japanese Dental Science Review
  
  Volume: 59 Pages: 1-7
- DOI
  10.1016/j.jdsr.2022.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-22K18401, KAKENHI-PROJECT-21K19607, KAKENHI-PROJECT-23K24549
[Journal Article] Orchestration of Immune Cells Contributes to Fibrosis in IgG4-Related Disease2022
- Author(s)
  Kaneko Naoki、Moriyama Masafumi、Maehara Takashi、Chen Hu、Miyahara Yuka、Nakamura Seiji
- Journal Title
  
  Immuno
  
  Volume: 2 Issue: 1 Pages: 170-184
- DOI
  10.3390/immuno2010013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-21KK0163, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-22K19631, KAKENHI-PROJECT-21H03141
[Journal Article] Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease.2022
- Author(s)
  Ryusuke M,Takashi M, Yuka M, Rusako K, Ryuichi A, Naoki K, Atsushi D, Cory A.P., Emanuel DT, Takako S, Yasuharu S, Hidetaka Y, Tamotsu K, John HS, Shiv P, Seiji N.
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: in press Issue: 2 Pages: 440-455.e17
- DOI
  10.1016/j.jaci.2022.03.034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-18KK0260
[Journal Article] Distinct disease-specific Tfh cell populations in two different fibrotic diseases: IgG4-related disease and Kimura's disease.2022
- Author(s)
  Munemura Ryusuke, Maehara Takashi, Yuka Murakami, Risako Koga, Ryuichi Aoyagi, Kaneko Naoki, John H Stone, Shiv Pillai, Nakamura Seiji.
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00553
[Journal Article] Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sj?gren’s syndrome2022
- Author(s)
  Kaneko Naoki、Chen Hu、Perugino Cory A.、Maehara Takashi、Munemura Ryusuke、Yokomizo Shiho、Sameshima Junsei、Diefenbach Thomas J.、Premo Katherine R.、Chinju Akira、Miyahara Yuka、Sakamoto Mizuki、Moriyama Masafumi、Stone John H.、Nakamura Seiji、Pillai Shiv
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 15427-15427
- DOI
  10.1038/s41598-022-19397-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17142, KAKENHI-PROJECT-21KK0163, KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-23K24548, KAKENHI-PROJECT-21H03141
[Journal Article] Neutralizing anti IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease2022
- Author(s)
  Jarrell Justin A.、Baker Matthew C.、Perugino Cory A.、Liu Hang、Bloom Michelle S.、Maehara Takashi、Wong Heidi H.、Lanz Tobias V.、Adamska Julia Z.、Kongpachith Sarah、Sokolove Jeremy、Stone John H.、Pillai Shiv S.、Robinson William H.
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 149 Issue: 1 Pages: 358-368
- DOI
  10.1016/j.jaci.2021.05.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03854
[Journal Article] CD163+ M2 Macrophages Promote Fibrosis in IgG4-Related Disease Via Toll-like Receptor 7/Interleukin-1 Receptor-Associated Kinase 4/NF-κB Signaling2022
- Author(s)
  Chinju Akira、Moriyama Masafumi、Kakizoe‐Ishiguro Noriko、Chen Hu、Miyahara Yuka、Haque A. S. M. Rafiul、Furusho Katsuhiro、Sakamoto Mizuki、Kai Kazuki、Kibe Kotono、Hatakeyama‐Furukawa Sachiko、Ito‐Ohta Miho、Maehara Takashi、Nakamura Seiji
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: in press Issue: 5 Pages: 1-10
- DOI
  10.1002/art.42043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-20K18727, KAKENHI-PROJECT-21K17142, KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-21K10075, KAKENHI-PROJECT-22K19631, KAKENHI-PROJECT-20K23085, KAKENHI-PROJECT-21H03141
[Journal Article] CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease2021
- Author(s)
  Perugino Cory A., Moriyama Masafumi（28名中24番目）, et al.
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 147 Issue: 1 Pages: 368-382
- DOI
  10.1016/j.jaci.2020.05.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-19K24097, KAKENHI-PROJECT-20H00553, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-21K10075, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-21H03141
[Journal Article] Mer tyrosine kinase as a possible link between resolution of inflammation and tissue fibrosis in IgG4-related disease2021
- Author(s)
  Rovati Lucrezia、Kaneko Naoki、Pedica Federica、Monno Antonella、Maehara Takashi、Perugino Cory、Lanzillotta Marco、Pecetta Simone、Stone John H、Doglioni Claudio、Manfredi Angelo A、Pillai Shiv、Della-Torre Emanuel
- Journal Title
  
  Rheumatology
  
  Volume: 60 Issue: 10 Pages: 4929-4941
- DOI
  10.1093/rheumatology/keab096
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03854
[Journal Article] Review of a novel disease entity, immunoglobulin G4-related disease2020
- Author(s)
  Maehara Takashi、Moriyama Masafumi、Nakamura Seiji
- Journal Title
  
  Journal of the Korean Association of Oral and Maxillofacial Surgeons
  
  Volume: 46 Issue: 1 Pages: 3-3
- DOI
  10.5125/jkaoms.2020.46.1.3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H04671
[Journal Article] B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease2020
- Author(s)
  Della-Torre Emanuel、Rigamonti Elena、Perugino Cory、Baghai-Sain Simona、Sun Na、Kaneko Naoki、Maehara Takashi、Rovati Lucrezia、Ponzoni Maurilio、Milani Raffaella、Lanzillotta Marco、Mahajan Vinay、Mattoo Hamid、Molineris Ivan、Deshpande Vikram、Stone John H.、Falconi Massimo、Manfredi Angelo A.、Pillai Shiv
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 145 Issue: 3 Pages: 968-981.e14
- DOI
  10.1016/j.jaci.2019.07.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-19H03854
[Journal Article] B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma2020
- Author(s)
  Minici Claudia、Rigamonti Elena、Lanzillotta Marco、Monno Antonella、Rovati Lucrezia、Maehara Takashi、Kaneko Naoki、Deshpande Vikram、Protti Maria Pia、De Monte Lucia、Scielzo Cristina、...Pillai Shiv、Manfredi Angelo A.、Della-Torre Emanuel
- Journal Title
  
  OncoImmunology
  
  Volume: 9 Issue: 1 Pages: 1794359-1794359
- DOI
  10.1080/2162402x.2020.1794359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0260
[Journal Article] Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis2020
- Author(s)
  Maehara Takashi、Kaneko Naoki、Perugino Cory A.、Mattoo Hamid、Kers, Jesper、Allard-Chamard Hugues、Mahajan Vinay S.、Liu Hang、Murphy Samuel J.H.、Ghebremichael Musie、Fox David、Payne Aimee S.、Lafyatis Robert、Stone John H.、Khanna Dinesh、Pillai Shiv
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 5 Pages: 2451-2464
- DOI
  10.1172/jci131700
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-19H03854
[Journal Article] Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease.2020
- Author(s)
  Higashioka K, Ota Y, Maehara T, et. al.
- Journal Title
  
  BMC Immunol.
  
  Volume: 21 Issue: 1 Pages: 31-31
- DOI
  10.1186/s12865-020-00361-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-18K08410
[Journal Article] CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production.2019
- Author(s)
  Haque ASMR, Moriyama M, Kubota K, Ishiguro N, Sakamoto M, Chinju A, Mochizuki K, Sakamoto T, Kaneko N, Munemura R, Maehara T, Tanaka A, Hayashida JN, Kawano S, Kiyoshima T, Nakamura S.
- Journal Title
  
  Sci Rep.
  
  Volume: Oct 10;9(1) Issue: 1 Pages: 14611-14611
- DOI
  10.1038/s41598-019-51149-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11846, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-18K17218, KAKENHI-PROJECT-19K24097, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-16K11691
[Journal Article] Activated M2 macrophage contributes to the pathogenesis of IgG4-related disease via TLR7/IL-33 signalin.2019
- Author(s)
  Ishiguro N, Moriyama M, Furusho K, Furukawa S, Shibata T, Murakami Y, Chinju A, Haque ASMR, Gion Y, Ohta M, Maehara T, Tanaka A, Yamauchi M, Sakamoto M, Mochizuki K, Ono Y, Hayashida JN, Sato Y, Kiyoshima T, Yamamoto H, Miyake K, Nakamura S
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: Jan;72(1) Issue: 1 Pages: 166-178
- DOI
  10.1002/art.41052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11846, KAKENHI-PROJECT-17K17265, KAKENHI-PROJECT-19K24097, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-16K11691, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-18KK0260
[Journal Article] Pathogenesis of IgG4-related disease: a critical review.2019
- Author(s)
  Maehara T, Moriyama M, Nakamura S.
- Journal Title
  
  Odontology
  
  Volume: 107 Pages: 127-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03854
[Journal Article] Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis: a review.2019
- Author(s)
  Maehara T, Pillai S, Stone JH, Nakamura S.
- Journal Title
  
  Int J Oral Maxillofac Surg
  
  Volume: 印刷中 Issue: 7 Pages: 908-916
- DOI
  10.1016/j.ijom.2019.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-19H03854
[Journal Article] 2.Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report2019
- Author(s)
  Maehara T, Munemura R, Shimizu M, Kakizoe N, Kaneko N, Murakami Y, Moriyama M, Kiyoshima T, Kawano S, Nakamura S.
- Journal Title
  
  Medicine
  
  Volume: in press Issue: 50 Pages: e18300-e18300
- DOI
  10.1097/md.0000000000018300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09747, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-18KK0260
[Journal Article] The diagnostic utility of submandibular gland sonography and labial salivary gland biopsy in IgG4-related dacryoadenitis and sialadenitis: Its potential application to the diagnostic criteria2019
- Author(s)
  Sakamoto Mizuki、Moriyama Masafumi、Shimizu Mayumi、Chinju Akira、Mochizuki Keita、Munemura Ryusuke、Ohyama Keiko、Maehara Takashi、Ogata Kenichi、Ohta Miho、Yamauchi Masaki、Ishiguro Noriko、Matsumura Mayu、Ohyama Yukiko、Kiyoshima Tamotsu、Nakamura Seiji
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 2 Pages: 1-6
- DOI
  10.1080/14397595.2019.1576271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17265, KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-18K09747, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-18KK0260
[Journal Article] Pathogenesis of IgG4-related disease: a critical review2018
- Author(s)
  Maehara Takashi、Moriyama Masafumi、Nakamura Seiji
- Journal Title
  
  Odontology
  
  Volume: 107 Issue: 2 Pages: 127-132
- DOI
  10.1007/s10266-018-0377-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003
[Presentation] Granzyme K and Amphiregulin expressing cytotoxic CD4+ T cells and CD8+ T cells are potential drivers of a fibrotic inflammatory disease2024
- Author(s)
  TAKASHI MAEHARA
- Organizer
  The 5th International symposium on IgG4-related disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19607
[Presentation] Granzyme K and Amphiregulin expressing cytotoxic CD4+ T cells and CD8+ T cells are potential drivers of a fibrotic inflammatory disease2024
- Author(s)
  TAKASHI MAEHARA
- Organizer
  The 5th International symposium on IgG4-related disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24549
[Presentation] Single cell interrogation of T-lymphocytes infiltrating IgG4-related disease affected tissues: a novel perspective into the pathogenesis of IgG4-related disease2024
- Author(s)
  TAKASHI MAEHARA
- Organizer
  The 5th International symposium on IgG4-related disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24549
[Presentation] Single cell interrogation of T-lymphocytes infiltrating IgG4-related disease affected tissues: a novel perspective into the pathogenesis of IgG4-related disease2024
- Author(s)
  TAKASHI MAEHARA
- Organizer
  The 5th International symposium on IgG4-related disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19607
[Presentation] 口腔扁平上皮癌における治療標的T細胞の免疫チェックポイント分子の発現2023
- Author(s)
  前原隆、古賀理紗子、青柳龍一、宗村龍祐、川野真太郎
- Organizer
  第42回　日本口腔腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K19607
[Presentation] IgG4関連疾患の唾液腺病変における特異なT細胞について2022
- Author(s)
  前原隆、中村誠司
- Organizer
  第30回　日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00553
[Presentation] IgG4関連疾患における特異なT細胞について Disease specific T cells in IgG4-related disease -Latest approaches to elucidate the pathogenesis of this disease-2022
- Author(s)
  前原隆、Pillai Shiv、中村誠司
- Organizer
  第65回　日本腎臓病学会（招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-20H00553
[Presentation] IgG4関連疾患における特異なT細胞について Disease specific T cells in IgG4-related disease -Latest approaches to elucidate the pathogenesis of this disease-2022
- Author(s)
  前原隆、Pillai Shiv、中村誠司
- Organizer
  第65回　日本腎臓病学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00553
[Presentation] Single-cell transcriptome analysis identifies clonally-expanded infiltrating CD4+ and CD8+ cytotoxic T lymphocytes in IgG4-related disease2021
- Author(s)
  Takashi Maehara
- Organizer
  4th International symposium on IgG4-related disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19607
[Presentation] Single-cell transcriptome analysis identifies clonally-expanded infiltrating CD4+ and CD8+ cytotoxic T lymphocytes in IgG4-related disease2021
- Author(s)
  Takashi Maehara
- Organizer
  International symposium on IgG4-RD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] IgG4-related disease: Immunological insights into the pathogenesis2021
- Author(s)
  Takashi Maehara
- Organizer
  23rd Asia-Pacific League of Associations for Rheumatology Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] IgG4-related disease: Immunological insights into the pathogenesis: Immuno2021
- Author(s)
  Takashi Maehara
- Organizer
  23rd Asia-Pacific League of Associations for Rheumatology Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] IL-1 inducing inflammation by CD163+ M2 macrophages contributes to the fibrosis of IgG4-related disease via TLR7/IRAK4/NFkB signaling.2021
- Author(s)
  Akira Chinju, Masafumi Moriyama, Noriko Ishiguro, Miho Ohta, Takashi Maehara, Akihiko Tanaka, Mizuki Sakamoto, Haque A.S.M. Rafiul, Keita Mochizuki, Yuko Ono, Ryusuke Munemura, Jun-Nosuke Hayashida, and Seiji Nakamura
- Organizer
  Oral Bioscience & OBT Research Center Joint International Symposium 2021
- Data Source
  KAKENHI-PROJECT-19K22723
[Presentation] IgG4-related disease: Immunological insights into the pathogenesis2021
- Author(s)
  Takashi Maehara
- Organizer
  23rd Asia-Pacific League of Associations for Rheumatology Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19607
[Presentation] Single-cell transcriptome analysis identifies clonally-expanded infiltrating CD4+ and CD8+ cytotoxic T lymphocytes in IgG4-related disease2021
- Author(s)
  Takashi Maehara
- Organizer
  4th International symposium of IgG4-related disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] IgG4関連疾患の病因・病態と治療「自然免疫からみたIgG4関連疾患の病因・病態」2021
- Author(s)
  森山雅文、石黒乃理子、鎮守晃、坂本瑞樹、木部琴乃、前原隆、中村誠司
- Organizer
  日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22723
[Presentation] IgG4関連疾患においてTLR7はIRAK4/NFκBシグナルを介して線維化を惹起する2020
- Author(s)
  鎮守晃、森山雅文、柿添乃理子、古庄克宏、前原隆、伊東美穂、坂本瑞樹、望月敬太、宗村龍祐、中村誠司
- Organizer
  第65回（公社）日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K22723
[Presentation] IgG4関連疾患の臓器線維化と炎症の免疫学的病態解明2020
- Author(s)
  前原隆、宗村龍祐、金子直樹、村上祐香、中村誠司
- Organizer
  第65回　日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] IgG4関連疾患の病態形成におけるClonalに増殖したCD4+CTLとCD8+CTL細胞の病態への関与2020
- Author(s)
  前原隆、金子直樹、宗村龍祐、村上祐香、中村誠司
- Organizer
  第74回　日本口腔科学会
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] IgG4関連疾患の病態形成におけるClonalに増殖したCD4+CTLとCD8+CTL細胞の病態への関与2020
- Author(s)
  前原隆、金子直樹、宗村龍祐、村上祐香、中村誠司
- Organizer
  第74回　日本口腔科学会
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] IgG4関連疾患の臓器線維化と炎症の免疫学的病態解明2020
- Author(s)
  前原隆、宗村龍祐、金子直樹、村上祐香、中村誠司
- Organizer
  第65回　日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] 次世代シークエンサー解析が紐解く，全身性強皮症の病態における Clonal に増殖した CD4+T 細胞 -国際共同研究-2019
- Author(s)
  前原隆、PERUGINO Cory、金子直樹、MATTOO Hamid、宗村龍祐、山元英崇、PILLAI Shiv、中村誠司
- Organizer
  第73回NPO 法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] A novel disease entity, IgG4-related disease: Immunological insights into the pathogenesis2019
- Author(s)
  Takashi Maehara, Seiji Nakamura
- Organizer
  The 9th Japan-Thailand-Korea Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] A novel disease discovered and established in Japan: IgG4-related disease2019
- Author(s)
  Takashi Maehara
- Organizer
  4th Meeting of the International Association for Dental Research Asia Pacific Region
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] 次世代シークエンサー解析が紐解く，全身性強皮症の病態における Clonal に増殖した CD4+T 細胞 -国際共同研究-2019
- Author(s)
  前原隆、PERUGINO Cory、金子直樹、MATTOO Hamid、宗村龍祐、山元英崇、PILLAI Shiv、中村誠司
- Organizer
  第73回NPO 法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] IgG4関連疾患の病態と治療へ向けて2019
- Author(s)
  前原隆
- Organizer
  第28回　日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03854
[Presentation] 次世代シークエンサー解析が紐解く，全身性強皮症の病態における Clonal に増殖した CD4+T 細胞 -国際共同研究-2019
- Author(s)
  前原隆、Perugino Cory、金子直樹、Mattoo Hamid、宗村龍祐、山本英崇、Pillai Shiv、中村誠司
- Organizer
  第73回　日本口腔科学会総会
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] A novel disease entity, IgG4-related disease: Immunological insights into the pathogenesis2019
- Author(s)
  Takashi Maehara, Seiji Nakamura
- Organizer
  The 9th Japan-Thailand-Korea Joint Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] A Novel diseases discovered and established in 21st Century: IgG4-related disease - Mechanistic insights from both clinical and immunologic understanding of this condition -,2019
- Author(s)
  Takashi Maehara
- Organizer
  Kyudai Oral Bioscience & OBT Research Center Joint International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] 全身性強皮症患者の疾患特異的 T 細胞の発見と新規治療法の検討2019
- Author(s)
  前原隆、金子直樹、宗村龍祐、村上祐香、中村誠司
- Organizer
  第64回日本口腔外科学会・総会
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] IgG4関連疾患の病態と治療へ向けて2019
- Author(s)
  前原隆
- Organizer
  第28回　日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] A novel disease discovered and established in Japan: IgG4-related disease2019
- Author(s)
  Takashi Maehara
- Organizer
  4th Meeting of the International Association for Dental Research Asia Pacific Region
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] The expansion in lymphoid organs of IL-4+BATF+TFH cells is linked to IgG4 class switching in vivo2018
- Author(s)
  TAKASHI Maehara, HAMID Mattoo, NORIKO Ishiguro, MASAFUMI Moriyama, SEIJI Nakamura, SHIV Pillai
- Organizer
  96th GENERAL SESSION & EXHIBITION OF THE INTERNATIONAL ASSOCIATION FOR DENTAL RESEARCH
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] IgG4関連疾患の病態 -免疫学的アプローチ-2018
- Author(s)
  前原隆、Mattoo Hamid、Emanuel Della Torre、森山雅文、佐伯敬子、山元英崇、Stone John、Pillai Shiv、中村誠司
- Organizer
  日本シェーグレン症候群学会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] Clonalに増殖したCD4+CTLとTfh細胞はIgG4関連疾患の病態形成に関与する2018
- Author(s)
  前原隆
- Organizer
  第46回　日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] Clonalに増殖したCD4+CTLとTfh細胞はIgG4関連疾患の病態形成に関与する2018
- Author(s)
  前原隆、MATTOO Hamid、森山雅文、柿添乃理子、坂本瑞樹、佐伯敬子、山元英崇、STONE John、PILLAI Shiv、中村誠司
- Organizer
  第63回日本口腔外科学会・総会
- Data Source
  KAKENHI-PROJECT-18KK0260
[Presentation] DNA microarray analysis of submandibular glands in IgG4-related dacryoadenitis and sialoadenitis.2015
- Author(s)
  Miho Ohta, Masafumi Moriyama, Takashi Maehara. et al.
- Organizer
  The 13th international Symposium on Sjogren's Syndrome
- Place of Presentation
  Bergen/Norway
- Year and Date
  2015-05-19
- Data Source
  KAKENHI-PROJECT-26861728

1. Nakamura Seiji (60189040)

# of Collaborated Projects: 8 results

# of Collaborated Products: 42 results
2. 森山雅文 (20452774)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
3. 新納宏昭 (20380636)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 山元英崇 (30404073)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. 村川泰裕 (50765469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 川野真太郎 (00398067)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 柴田琢磨 (30554505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 安河内友世 (70507813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 坪井洋人 (80580505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 川野充弘 (20361983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 河野通仁 (00835192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 古賀理紗子 (41003635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 清島保 (20264054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 金子直樹 (80805284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 林田淳之介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 吉野真弓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 坂本瑞樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maehara Takashi 前原 隆

MAEHARA TAKASHI 前原 隆

前原 隆 マエハラ タカシ

Research Projects

Research Products

Co-Researchers

細胞傷害性T細胞と相互連関する特異なB細胞同定の為の国際共同研究Principal Investigator

Principal Investigator

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IgG4関連疾患に特異な細胞傷害性T細胞の活性化経路の全容解明Principal Investigator

Principal Investigator

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難治性癌の悪性形質獲得に関わる特異な制御性T細胞サブセットの同定とその活性化機構

Principal Investigator

Project Period (FY)

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口腔扁平苔癬の創薬ターゲットの探索～病因T細胞と関連エンハンサーRNAの同定～

Principal Investigator

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IgG4関連疾患の異所性胚中心オルガノイドから病因解明と新規モデル動物の樹立Principal Investigator

Principal Investigator

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IgG4関連疾患の創薬ターゲットとなり得る病因関連エンハンサーRNAの探索Principal Investigator

Principal Investigator

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Immunologic specificity based pathogenesis of IgG4-related diseases and validation in mouse models of the disease

Principal Investigator

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唾液中の可溶性マーカーに着目したIgG4関連疾患の新たな診断方法の開発

Principal Investigator

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Research Institution

Elucidation of the mechanisms of orang fibrosis using patients with IgG4-related disease and their mouse modelsPrincipal Investigator

Principal Investigator

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Research Institution

New therapy targets for IgG4-RD and other human autoimmune disease focused on clonal expanded T and B cells.Principal Investigator

Principal Investigator

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Research Institution

IgG4関連疾患の病態解明に向けた免疫学的研究―異所性胚中心形成とTh細胞―Principal Investigator

Principal Investigator

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[Book] B細胞とT細胞から紐解くIgG4関連疾患の病態形成メカニズム2024

Author(s)

Total Pages

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Data Source

[Book] IgG4関連疾患と木村病における疾患特異的な濾胞性Ｔ細胞.2023

Author(s)

Total Pages

Maehara Takashi 前原隆

MAEHARA TAKASHI 前原隆

前原隆マエハラタカシ

[Book] IgG4 関連疾患と木村病における疾患特異的な濾胞性T細胞2023