NIIRO Hiroaki 新納宏昭

Researcher Number	20380636
Affiliation (Current)	2022: 九州大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 九州大学, 医学研究院, 教授 2014 – 2015: 九州大学, 大学病院, 准教授 2013: 九州大学, 大学病院, 講師 2013: 九州大学, 大学病院, 講師(Lecture) 2007 – 2012: Kyushu University, 大学病院, 助教 2011: 九州大学, 病院, 助教 2005 – 2006: 九州大学, 大学病院, 特任助手
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator Gastroenterology / Medium-sized Section 57:Oral science and related fields / Basic Section 57060:Surgical dentistry-related / Hematology / Otorhinolaryngology / Surgical dentistry / Medical sociology
Keywords	Principal Investigator 自己免疫疾患 / 免疫学 / 内科 / 細胞・組織 / シグナル伝達 / B細胞 / Autoimmune disease / Cell and tissue / Immunology / Signal transduction / Internal medicine … More Except Principal Investigator … More IgG4関連疾患 / B細胞 / マクロファージ / T細胞 / 消化器癌 / エクソゾーム / 疾患モデルマウス / T細胞サブセット / Toll様受容体 / モデルマウス / 自然免疫 / M2マクロファージ / IgG4-RD / CD4+CTL / シェーグレン症候群 / microRNA / 転写因子 / 造血幹細胞 / マイクロRNA / 末梢血 / バイオマーカー / 癌 / 生体分子 / 内耳再生 / レーザーキャプチャーマイクロダイセクション / Musashil / マイクロアレイ / 内耳障害 / Musasahi1 / chick / 消化器がん / がん幹細胞 / 微小環境 / 可溶性因子 / 癌幹細胞 / 濾胞性T細胞 / B細胞サブセット / CCL16 / マクロファージサブセット / Toll 様受容体 / Resients as teachers / Near Peer Learinig / EPA / Residents as teachers / 若手指導医養成 / 必須 / 医学教育 / 若手指導者養成 / 木村病 / IgE / IgG4 / T / B / Tfh / 遺伝子解析 / CD4+T細胞 / サイトカイン / クラススイッチ / 線維化 / 細胞障害性T細胞 / CD8+CTL / Tリンパ球 / Bリンパ球 / 線維芽細胞 / CD4+ / IgG4産生B細胞 / IgG4疾患モデルマウス / 病因 / TLR7 Less

Toll様受容体7シグナルに着目したIgG4関連疾患の新規治療法の開発
- Principal Investigator
  
  森山雅文
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
自己免疫疾患におけるT-bet＋エフェクターB細胞の役割Principal Investigator
- Principal Investigator
  
  新納宏昭
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyushu University
IgG4関連疾患の免疫学的特異性を基盤とした病因解明と疾患モデルマウスによる検証
- Principal Investigator
  
  中村誠司
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
IgG4関連疾患とその世界初モデルマウスにおける臓器線維化メカニズム解明
- Principal Investigator
  
  前原隆
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Role of cytokine-producing effector B cells in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  NIIRO HIROAKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyushu University
IgG4関連疾患の病因解明と新規治療戦略 -特異なT・B細胞を標的として-
- Principal Investigator
  
  前原隆
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
Elucidation of mechanism on IgG4-related disease and establishment of disease model mouse
- Principal Investigator
  
  Nakamura Seiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Development of Near Pear Learning Program based on Entrustable Professional Activities
- Principal Investigator
  
  Kikukawa Makoto
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical sociology
- Research Institution
  Kyushu University
Role of effector B cells and regulatory B cells in the pathogenesis of autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  NIIRO HIROAKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyushu University
Analysis of plasma exosome containing micro RNA in gastrointestinal cancer
- Principal Investigator
  
  BABA Eishi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
Identification of human regulatory B cells and their role in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  NIIRO HIROAKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyushu University
Functional analysis and clinical application of micro RNAs in gastrointestinal tumor-derived exosomes
- Principal Investigator
  
  BABA Eishi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyushu University
c-Cbl-interacting protein of 85 kDa(CIN85) regulates the function of autoreactive B cellsPrincipal Investigator
- Principal Investigator
  
  NIIRO Hiroaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyushu University
Research of novel genes which contribute to inner ear regeneration
- Principal Investigator
  
  OHASHI Mitsuru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyushu University
c-Cbl-interacting protein of 85 kDa (CIN85) regulates the function of normal and autoimmune B cellsPrincipal Investigator
- Principal Investigator
  
  NIIRO Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyushu University
幹細胞制御に関わるマイクロRNAのプロスペクティブな分離・同定法の開発
- Principal Investigator
  
  赤司浩一
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kyushu University
Regulation of B cell function by a novel adaptor and its role in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  NIIRO Hiroaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  KYUSHU UNIVERCITY

[Book] 今日の治療指針　2019年版［デスク判］2019
- Author(s)
  福井次矢　(分担　新納宏昭: 高安動脈炎、巨細胞性動脈炎)
- Total Pages
  2160
- Publisher
  医学書院
- ISBN
  9784260036504
- Data Source
  KAKENHI-PROJECT-18K08410
[Book] 全身性エリテマトーデス診療ガイドライン20192019
- Author(s)
  厚生労働科学研究費補助金難治性疾患等政策研究事業　自己免疫疾患に関する調査研究（自己免疫班）、日本リウマチ学会 (分担新納宏昭)
- Total Pages
  280
- Publisher
  南山堂
- ISBN
  9784525234713
- Data Source
  KAKENHI-PROJECT-18K08410
[Book] 内科学第9版(好酸球増加症,組織球増殖症)2007
- Author(s)
  新納宏昭他
- Publisher
  朝倉書店 (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591047
[Book] 内科学第9版(好酸球増加症,組織球増殖症)2007
- Author(s)
  新納宏昭他
- Publisher
  朝倉書店(in press)
- Data Source
  KAKENHI-PROJECT-17591047
[Book] インターロイキン-3(IL-3),IL-4,IL-52005
- Author(s)
  新納宏昭
- Total Pages
  4
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-17591047
[Book] インターロイキンー3(IL-3),IL-4,IL-52005
- Author(s)
  新納宏昭
- Total Pages
  4
- Publisher
  日本臨牀社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591047
[Journal Article] Increased Proportion of CD226+ B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus2021
- Author(s)
  61.Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, Mitoma H, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 713225-713225
- DOI
  10.3389/fimmu.2021.713225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-21K08460
[Journal Article] HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: a retrospective study2021
- Author(s)
  64.Kushimoto K, Ayano M, Nishimura K, Nakano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 23 Pages: 238-238
- DOI
  10.1186/s13075-021-02618-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-21K08460
[Journal Article] Human PD-1hiCD8+ T cells are a cellular source of IL-21 in rheumatoid arthritis.2021
- Author(s)
  Higashioka K, Yoshimura M, Sakuragi T, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Horiuchi T, Akashi K, Niiro H.
- Journal Title
  
  Front Immunol
  
  Volume: 12 Pages: 654623-654623
- DOI
  10.3389/fimmu.2021.654623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-21K08460
[Journal Article] Type 1 helper T cells generate CXCL9/10-producing T-bet+ effector B cells potentially involved in the pathogenesis of rheumatoid arthritis.2021
- Author(s)
  Nakayama T, Yoshimura M, Higashioka K, Miyawaki K, Ota Y, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Akashi K, Horiuchi T, Niiro H.
- Journal Title
  
  Cell Immunol
  
  Volume: 360 Pages: 104263-104263
- DOI
  10.1016/j.cellimm.2020.104263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-18K08410
[Journal Article] Generation of a novel CD30 + B cell subset producing GM‐CSF and its possible link to the pathogenesis of systemic sclerosis2020
- Author(s)
  Higashioka K, Kikushige Y, Ayano M, Kimoto Y, Mitoma H, Kikukawa M, Akahoshi M, Arinobu Y, Horiuchi T, Akashi K, Niiro H.
- Journal Title
  
  Clin Exp Immunol
  
  Volume: 201 Pages: 233-243
- DOI
  10.1111/cei.13477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-19H03564
[Journal Article] Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease2020
- Author(s)
  Higashioka K, Ota Y, Maehara T, et. al.
- Journal Title
  
  BMC Immunol
  
  Volume: 21 Pages: 21-31
- DOI
  10.1186/s12865-020-00361-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-18KK0260, KAKENHI-PROJECT-17H04671, KAKENHI-PROJECT-19H03854, KAKENHI-PROJECT-18K08410
[Journal Article] CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines.2019
- Author(s)
  Takaki-Kuwahara Ayako、Arinobu Yojiro、Miyawaki Kohta、Yamada Hisakata、Tsuzuki Hirofumi、Irino Kensuke、Ayano Masahiro、Kimoto Yasutaka、Mitoma Hiroki、Akahoshi Mitsuteru、Tsukamoto Hiroshi、Horiuchi Takahiko、Niiro Hiroaki、Akashi Koichi
- Journal Title
  
  Arthritis Res. Ther.
  
  Volume: 21 Pages: 198-198
- DOI
  10.1186/s13075-019-1984-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-19K08910, KAKENHI-PROJECT-19K17887, KAKENHI-PROJECT-19H03564
[Journal Article] CD34-selected versus unmanipulated autologous haematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: a post hoc analysis of a phase I/II clinical trial conducted in Japan.2019
- Author(s)
  Ayano M, Tsukamoto H, Mitoma H, Kimoto Y, Akahoshi M, Arinobu Y, Miyamoto T, Horiuchi T, Niiro H, Nagafuji K, Harada M, Akashi K
- Journal Title
  
  Arthritis Res. Ther.
  
  Volume: 21 Pages: 30-30
- DOI
  10.1186/s13075-019-1823-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09897, KAKENHI-PROJECT-16K09898, KAKENHI-PROJECT-16K19603, KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-19H03564
[Journal Article] Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study.2018
- Author(s)
  (2)Otsuka Y, Kiyohara C, Kashiwado Y, Sawabe T, Nagano S, Kimoto Y, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Niiro H, Akashi K, Horiuchi T
- Journal Title
  
  PLOS ONE
  
  Volume: 13
- DOI
  10.1371/journal.pone.0196368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-16K09897, KAKENHI-PROJECT-16K19603
[Journal Article] Long-term efficacy of infliximab treatment and the predictors of treatment outcomes in patients with refractory uveitis associated with Beh?et’s disease2018
- Author(s)
  (1)Ueda S, Akahoshi M, Takeda A, Inoue Y, Omoto A, Ayano M, Kimoto Y, Mitoma H, Arinobu Y, Niiro H, Tsukamoto H, Horiuchi T, Hikita SI, Fukuhara T, Ishibashi T, Sonoda KH, Akashi K
- Journal Title
  
  Eur J Rheumatol.
  
  Volume: 5 Pages: 9-15
- DOI
  10.5152/eurjrheum.2017.17068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-16K19603, KAKENHI-PROJECT-15K10896, KAKENHI-PROJECT-18K09471
[Journal Article] Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody2018
- Author(s)
  (3)Yamaguchi K, Mishima K, Ohmura H, Hanamura F, Ito M, Nakano M, Tsuchihashi K, Ota SI, Wada N, Uchi H, Ariyama H, Kusaba H, Niiro H, Akashi K, Baba E
- Journal Title
  
  Cancer Science
  
  Volume: 109 Pages: 3032-3042
- DOI
  10.1111/cas.13758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08410, KAKENHI-PROJECT-16H06391
[Journal Article] Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration.2017
- Author(s)
  Wakasaki T, Niiro H, Jabbarzadeh-Tabrizi S, Ohashi M, Kimitsuki T, Nakagawa T, Komune S, Akashi K
- Journal Title
  
  BMC Neurosci
  
  Volume: 18 Pages: 64-64
- DOI
  10.1186/s12868-017-0382-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09528
[Journal Article] Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes.2017
- Author(s)
  Tsuzuki H, Arinobu Y, Miyawaki K, Takaki A, Ota SI, Ota Y, Mitoma H, Akahoshi M, Mori Y, Iwasaki H, Niiro H, Tsukamoto H, and Akashi K.
- Journal Title
  
  Immunology
  
  Volume: 150 Pages: 64-73
- DOI
  10.1111/imm.12667
- NAID
  40021132441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09527, KAKENHI-PROJECT-15K15365, KAKENHI-PROJECT-15K09528
[Journal Article] Safety, Pharmacokinetics and Pharmacodynamics of Epratuzumab in Japanese Patients with Moderate-to-Severe Systemic Lupus Erythematosus: Results from a Phase 1/2 Randomized Study.2016
- Author(s)
  Tsuru T, Tanaka Y, Kishimoto M, Saito K, Yoshizawa S, Takasaki Y, Miyamura T, Niiro H, Morimoto S, Yamamoto J, Lledo-Garcia R, Shao J, Tatematsu S, Togo O, Koike T
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 26 Pages: 87-93
- DOI
  10.3109/14397595.2015.1079292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09528
[Journal Article] Long-term clinical safety and efficacy of brodalumab in the treatment of Japanese patients with moderate-to-severe plaque psoriasis.2016
- Author(s)
  Umezawa Y, Nakagawa H, Niiro H, Ootaki K the Japanese Brodalumab Study Group
- Journal Title
  
  J Eur Acad Dermatol Venereol.
  
  Volume: 30 Pages: 1957-1960
- DOI
  10.1111/jdv.13785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09528
[Journal Article] Generation mechanism of RANKL+ effector memory B cells: its relevance to the pathogenesis of rheumatoid arthritis.2016
- Author(s)
  Ota Y, Niiro H, Ota S, Ueki N, Tsuzuki H, Nakayama T, Mishima K, Higashioka K, Jabbarzadeh-Tabrizi S, Mitoma H, Akahoshi M, Arinobu Y, Kukita A, Yamada H, Tsukamoto H, and Akashi K.
- Journal Title
  
  Arthritis Reseach & Therapy
  
  Volume: 18 Pages: 67-67
- DOI
  10.1186/s13075-016-0957-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09527, KAKENHI-PROJECT-15K09528, KAKENHI-PROJECT-16K10908
[Journal Article] Brodalumab, a human anti-interleukin-17-receptor antibody in the treatment of Japanese patients with moderate-to-severe plaque psoriasis: Efficacy and safety results from a phase II randomized controlled study.2016
- Author(s)
  Nakagawa H, Niiro H, Ootaki K Japanese brodalumab study group
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 81 Pages: 44-52
- DOI
  10.1016/j.jdermsci.2015.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09528
[Journal Article] Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis.2015
- Author(s)
  Tanaka A, Tsukamoto H, Mitoma H, Kiyohara C, Ueda N, Ayano M, Ohta S, Kimoto Y, Akahoshi M, Arinobu Y, Niiro H, Tada Y, Horiuchi T and Akashi K.
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 17 Pages: 17-27
- DOI
  10.1186/s13075-015-0547-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591465, KAKENHI-PROJECT-15K09527, KAKENHI-PROJECT-15K09528
[Journal Article] Increased CD226 Expression on CD8+ T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis.2015
- Author(s)
  Ayano M, Tsukamoto H, Kohno K, et al.
- Journal Title
  
  J Immunol.
  
  Volume: 195 Pages: 892-900
- DOI
  10.4049/jimmunol.1403046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09527, KAKENHI-PROJECT-15K09528, KAKENHI-PROJECT-15K15365, KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-25253069
[Journal Article] A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression2015
- Author(s)
  Kikushige Y, Miyamoto T, Yuda J, Jabbarzadeh-Tabrizi S, Shima T, Takayanagi S, Niiro H, Yurino A, Miyawaki K, Takenaka K, Iwasaki H, Akashi K
- Journal Title
  
  Cell Stem Cell
  
  Volume: 17 Pages: 341-341
- DOI
  10.1016/j.stem.2015.07.011
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09528, KAKENHI-PROJECT-26461424, KAKENHI-PROJECT-15K15365, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25461424, KAKENHI-PROJECT-26713034
[Journal Article] Charateristics of MPO-ANCA-positive granulomatosis with polyangiitis: a retrospective multi-center study in Japan.2015
- Author(s)
  Ono N, Niiro H, Ueda A, Sawabe T, Nishizaka H, Furugo I, Yoshizawa S, Yoshizawa S, Tsukamoto H, Kiyohara C, Tada Y, Horiuchi
- Journal Title
  
  Rheumatol Int.
  
  Volume: 35 Pages: 555-559
- DOI
  10.1007/s00296-014-3106-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591450, KAKENHI-PROJECT-15K09528
[Journal Article] Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus.2015
- Author(s)
  Iwata S, Yamaoka K, Niiro H, Jabbarzadeh-Tabrizi S, Wang SP, Kondo M, Yoshikawa M, Akashi K, Tanaka
- Journal Title
  
  Lupus
  
  Volume: 24 Pages: 695-704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591450
[Journal Article] Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy.2014
- Author(s)
  Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A, Kono T, Hafezi-Moghadam A, Ishibashi T.
- Journal Title
  
  FASEB J
  
  Volume: 28 Pages: 131-142
- DOI
  10.1096/fj.13-229740
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592573, KAKENHI-PROJECT-23592574, KAKENHI-PROJECT-24591450, KAKENHI-PROJECT-25293224
[Journal Article] Reduced carotid intima-media thickness in systemic lupus erythematosus patients treated with cyclosporine A.2014
- Author(s)
  Oryoji K, Kiyohara C, Horiuchi T, Tsukamoto H, Niiro H, Shimoda T, Akashi K, Yanase T
- Journal Title
  
  Modern rheumatology
  
  Volume: 24 Pages: 86-92
- DOI
  10.3109/14397595.2013.852838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591450, KAKENHI-PROJECT-24591465
[Journal Article] The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor alpha2013
- Author(s)
  Ueda N, Tsukamoto H, Mitoma H, Ayano M, Tanaka A, Ohta S, Inoue Y, Arinobu Y, Niiro H, Akashi K, Horiuchi T.
- Journal Title
  
  Inflamm Bowel Dis
  
  Volume: 19 Pages: 1224-1231
- DOI
  10.1097/mib.0b013e318280b169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591463, KAKENHI-PROJECT-23591464, KAKENHI-PROJECT-24591450, KAKENHI-PROJECT-24591465
[Journal Article] PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells2013
- Author(s)
  Yuki H
- Journal Title
  
  BLOOD
  
  Volume: 121 Pages: 962-970
- DOI
  10.1182/blood-2012-05-431429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249039, KAKENHI-PROJECT-23591395, KAKENHI-PROJECT-24591450, KAKENHI-PUBLICLY-25118719, KAKENHI-PLANNED-22130002
[Journal Article] Amplification of toll-like receptor-mediated signaling through Syk in human B activation.2012
- Author(s)
  Iwata S, Yamaoka K, Niiro H, Nakano K, Wang SP, Akashi K, and Tanaka Y
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 129 Pages: 1594-1601
- DOI
  10.1016/j.jaci.2012.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591450
[Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.2012
- Author(s)
  Niiro H,…, Tsukamoto H, et al(16名中12番目)
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 2263-2273
- DOI
  10.1182/blood-2011-04-351965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591266, KAKENHI-PROJECT-24590944, KAKENHI-PROJECT-24591450, KAKENHI-PROJECT-24591465
[Journal Article] Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity.2012
- Author(s)
  Tanaka A, Tsukamoto H, Mitoma H, Kiyohara C, Ueda N, Ayano M, Ohta SI, Inoue Y, Arinobu Y, Niiro H, Horiuchi T, and Akashi K
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591450
[Journal Article] The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.2012
- Author(s)
  Shimoda S, Tsuneyama K, et al.
- Journal Title
  
  Clin Exp Immunol
  
  Volume: 168(3) Pages: 279-284
- DOI
  10.1111/j.1365-2249.2012.04581.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24591450
[Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor sign aling in human B cells2012
- Author(s)
  Niiro H, et al
- Journal Title
  
  Blood
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590816
[Journal Article] CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells2012
- Author(s)
  Hiroaki Niiro, Eishi Baba, Koichi Akashi et al
- Journal Title
  
  Blood
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590816
[Journal Article] Self-renewing hematopoietic stem cell is theprimary target in pathogenesis ofhuman chron is lymphocytic leukemia2011
- Author(s)
  Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, Mort Y, lino T, Yamauchi T, Eta T, Niiro H, Iwasaki H, Takenaka K, and Akashi K
- Journal Title
  
  Cancer Cell
  
  Volume: 20(2) Pages: 246-259
- DOI
  10.1016/j.ccr.2011.06.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267, KAKENHI-PROJECT-22249039
[Journal Article] Analysis of immune re constitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis : predominant re constitution of Thl CD4+ T cells2011
- Author(s)
  Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, and Akashi K
- Journal Title
  
  Rheumatology
  
  Volume: 50(5) Pages: 944-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267
[Journal Article] Interaction between Toll-like receptors and natural iiller cells in the destruction of bile ducts in primary biliary cirrhosis2011
- Author(s)
  Shimoda S.
- Journal Title
  
  Hepatology
  
  Volume: 53(4) Pages: 1270-1281
- DOI
  10.1002/hep.24194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590433, KAKENHI-PROJECT-21591267
[Journal Article] Tacrolimus is effective for lupus nephritis patients with persistent proteinuria2010
- Author(s)
  Uchino A, Tsukamoto H, Nakashima H, Yoshizawa S, Furugo I, Mitoma H, Oryoji K, Shimoda T, Niiro H, Tada Y, Yano T, Nonaka T, Oishi R, Akashi K, and Horiuchi T
- Journal Title
  
  Crin Exp Rheumatol
  
  Volume: 28(1) Pages: 6-12
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20346231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267
[Journal Article] A critical role of c-Cbl interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas via the Ras-ERK pathway2010
- Author(s)
  Wakasaki T, Masuda M, Niiro H, Jabbarzadeh-Tabrizi S, Neda K, Taniyama T, Komune S, and Akashi K
- Journal Title
  
  Neoplasia
  
  Volume: 12(10) Pages: 789-796
- URL
  http://www.neoplasia.com8pdf/manuscript/v12i10/neo10396.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267
[Journal Article] SLEにおけるinterferon signature:発見から臨床試験までの道のり2010
- Author(s)
  新納宏昭, ほか
- Journal Title
  
  リウマチ科
  
  Volume: 43 Pages: 427-433
- Data Source
  KAKENHI-PROJECT-21591267
[Journal Article] T cell leukemia/lymphoma 1 and Galectin-l regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins2009
- Author(s)
  JabbarzadehTabrizi S, Niiro H, Masui M, Yoshimoto G, Iino T, Kikushige Y, Wakasaki T, Baba E, Shimoda S, Miyamoto T, Hara T, Akashi K
- Journal Title
  
  J. Immunol
  
  Volume: 182(3) Pages: 1490-1499
- URL
  http://www.jimmunol.org/content/182/3/1490.long
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267
[Journal Article] Identification of the human eosinophil lineagecommitted progenitor : revision of phenotypic definition of the human common myeloid progenitor2009
- Author(s)
  Mori Y, Iwasaki H, Kohno K, Yoshimoto G, Kikushige Y, Okeda A, Uike N, Niiro H, Takenaka K, Nagafuji K, Miyamoto T, Harada M, Takatsu K, Akashi K
- Journal Title
  
  J. Exp. Med
  
  Volume: 206(1) Pages: 183-193
- DOI
  10.1084/jem.20081756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267
[Journal Article] FLTs-ITD upregulates MCL-l to promote survival of stem cells in acute myeloid leukemia via FLTs-ITD specific STATs activation Blood2009
- Author(s)
  Yoshimoto G, Miyamoto T, Jabbarzadeh Tabrizi S, lino T, Rocnik IL, Kikushige Y, Mort Y, Shima T, Iwasaki H, Takenaka K, Nagafuji K, Mizuno S-I, Niiro H, Gilliland GD, and Akashi K
- Volume
  114(24)
- Pages
  5034-5043
- DOI
  10.1182/blood-2008-12-196055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591267
[Journal Article] Biliary epithelial cells and primary biliary cirrhosis : the role of liverinfiltrating mononuclear cells2008
- Author(s)
  Shimoda S, Harada K, Niiro H, Yoshizumi T, Soejima Y, Taketomi A, Maehara Y, Tsuneyama K, Nakamura M, Komori A, Migita K, Nakanuma Y, Ishibashi H, Selmi C, Gershwin ME
- Journal Title
  
  Hepatology 47(3)
  
  Pages: 958-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591169
[Journal Article] B cell activation regulates exosomal HLA production2008
- Author(s)
  Arita S, Baba E, Shibata Y, Niiro H, Shimoda S, Isobe T, Kusaba H, Nakano S, Harada M
- Journal Title
  
  Eur. J. Immunol 38(5)
  
  Pages: 1423-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591169
[Journal Article] Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival2008
- Author(s)
  Kikushige Y, Yoshimoto G, Miyamoto T, Iino T, Mori Y, Iwasaki H, Niiro H, Takenaka K, Nagafuji K, Harada M, Ishikawa F, Akashi K
- Journal Title
  
  J. Immunol 180(11)
  
  Pages: 7358-7367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591169
[Journal Article] The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways2007
- Author(s)
  Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, Onohara S, Miyamoto T, Minagawa H, Fujii SI, Shultz LD, Harada M, Akashi K
- Journal Title
  
  Blood 110(10)
  
  Pages: 3591-3600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591169
[Journal Article] Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis2007
- Author(s)
  Kawano A, Shimoda S, Kamihira T, Ishikawa F, Niiro H, Soejima Y, Taketomi A, Maehara Y, Nakamura M, Komori A, Migita K,Ishibashi H, Azuma M, Gershwin ME, Harada M
- Journal Title
  
  J. Immunol 179(5)
  
  Pages: 3315-3324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591169
[Journal Article] Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice2007
- Author(s)
  Sadanaga A, Nakashima H, Akahoshi M, Masutani K, Miyake K, Igawa T, Sugiyama N, Niiro H, Harada M
- Journal Title
  
  Arthritis Rheum 56(5)
  
  Pages: 1618-1628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591169
[Presentation] 当院SLE患者に対するベリムマブ使用後の臨床経過の検討2021
- Author(s)
  吉村元樹、三嶋耕司、木本泰孝、綾野雅宏、三苫弘喜、小野伸之、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第62回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-21K08460
[Presentation] 活動性残存全身性エリテマトーデスに対する追加治療：ヒドロキシクロロキン vs タクロリムス2021
- Author(s)
  綾野雅宏、木本泰孝、三苫弘喜、小野伸之、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第62回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-21K08460
[Presentation] Type I and type II anti-CD202021
- Author(s)
  Hiroaki Niiro
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08460
[Presentation] 全身性エリテマトーデスに対する初回寛解導入治療後の早期寛解達成に関連する因子の検討2021
- Author(s)
  綾野雅宏、木本泰孝、三苫弘喜、小野伸之、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08460
[Presentation] 実臨床におけるベリムマブ使用下でのSLE患者の臨床経過の検討2020
- Author(s)
  吉村元樹、三嶋耕司、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] 肺病変・慢性感染症合併の関節リウマチ患者における生物学的製剤の使用2020
- Author(s)
  吉村元樹、三嶋耕司、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] Identification of IFN-γ-producing Effector B Cells in Humans: Their Relevance to the Pathogenesis of Systemic Lupus Erythematosus2019
- Author(s)
  Kazuhiko Higashioka, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro
- Organizer
  2019 ACR/ARP Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] Activation of caspase-1 in CD16-positive monocyte and correlation with disease activity in systemeic lupus erythmatosus2019
- Author(s)
  Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] Pathologic role of activated SLAMF7+Tfh1 cells in facilitating IgG4 production by B cells in IgG4-related disease2019
- Author(s)
  Kazuhiko Higashioka, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] Tumor Necrosis Factor Receptor 2 Signaling Potentiates Proliferation and Suppressive Activities of Follicular Regulatory T Cells2019
- Author(s)
  Shotaro Kawano, Hiroki Mitoma, Shoichiro Inokuchi, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro
- Organizer
  2019 ACR/ARP Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] A novel IL-21-producing CD8+ T cell subset involved in the pathogenesis of rheumatoid arthritis2019
- Author(s)
  Kazuhiko Higashioka, Hiroaki Niiro
- Organizer
  Keystone Symposia B Cell-T Cell Interactions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] キャッスルマン病2018
- Author(s)
  新納宏昭
- Organizer
  第33回日本臨床リウマチ学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] Distinct Roles of Tfh2, SLAMF7+ Tfh1 Cells and Th1 Cells in the Pathogenesis of IgG4-RD2018
- Author(s)
  Kazuhiko Higashioka, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro.
- Organizer
  2018 ACR/ARHP Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] 膠原病とエフェクターB細胞2018
- Author(s)
  新納宏昭
- Organizer
  第46回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] Deoxyribonuclease 1-like-3 Digests Self-DNA from Dead Cells and Prevents Autoimmunity2018
- Author(s)
  （5）Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro
- Organizer
  2018 ACR/ARHP Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] 関節リウマチにおけるIL-21産生性CD8+T細胞の役割2018
- Author(s)
  東岡和彦、中山剛志、三嶋耕司、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08410
[Presentation] 一般血液検査値による関節リウマチに対する生物製剤治療効果予測の可能性2017
- Author(s)
  中川仁、小山芳伸、川上純、植木幸孝、塚本浩、永野修司、内野愛弓、大田俊行、赤星光輝、綾野雅宏、三苫弘喜、木本泰孝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] コラーゲン誘導関節炎モデルマウスにおける自然リンパ球の分化と機能に関する検討2017
- Author(s)
  髙木綾子、有信洋二郎、大塚恭子、入野健佑、押領司大助、大田友里、久本仁美、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、塚本浩、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 関節リウマチ患者のリンパ球サブセットに対するアバタセプトの経時的作用2017
- Author(s)
  三嶋耕司、大田俊一郎、井上靖、吉澤誠司、吉澤滋、永野修司、西坂浩明、澤部琢哉、押領司健介、多田芳史、小山芳伸、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、大塚毅、上田章、大田俊行、中島衡、塚本浩、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 全身性強皮症におけるGM-CSF産生性エフェクターB細胞の役割2017
- Author(s)
  東岡和彦、大田友里、三嶋耕司、中山剛志、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第45回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] Rho activation plays an important role in the additive effect between methotrexate and anti-TNF agents in TNF-producing cells.2017
- Author(s)
  Qiaolei Wang, Hiroki Mitoma, Yasutaka Kimoto, Masahiro Ayano, Mituteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, and Takahiko Horiuchi
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 関節リウマチに対するイグラチモド投与における腎障害の検討2017
- Author(s)
  猪口翔一朗、綾野雅宏、河野正太郎、三苫弘喜、木本泰孝、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第54回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 全身性強皮症におけるGM-CSF産生性エフェクターB細胞の役割2017
- Author(s)
  東岡和彦、大田友里、三嶋耕司、中山剛志、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 大型血管炎の病態とサイトカインの役割2017
- Author(s)
  新納宏昭
- Organizer
  第45回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] トシリズマブ治療による関節リウマチ患者の酸化ストレスマーカーの評価-52週解析-2017
- Author(s)
  新納宏昭、綾野雅宏、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、押領司健介、井上靖、澤部琢哉、永野修司、西坂浩明、吉澤誠司、多田芳史、吉澤滋、大塚毅、中島衡、赤司浩一、堀内孝彦
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] MTX-LPDを発症した関節リウマチ患者の治療経過および活動性推移に関する検討2017
- Author(s)
  東岡和彦、綾野雅宏、柏戸佑介、猪口翔一朗、木本泰孝、三苫弘喜、赤星光輝、有信洋二郎、赤司浩一、堀内孝彦、新納宏昭
- Organizer
  第54回九州リウマチ学会
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] サイトカイン産生性エフェクターB細胞2016
- Author(s)
  新納宏昭
- Organizer
  第44回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2016-09-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] IgG4関連疾患における末梢血および組織リンパ球の免疫学的解析2016
- Author(s)
  大田友里、古川祥子、中山剛志、三嶋耕司、東岡和彦、高木綾子、猪口翔一郎、中川仁、中野翔太、押領司大助、三苫弘喜、赤星光輝、有信洋二郎、森山雅文、中村誠司、新納宏昭、塚本浩、赤司浩一
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] Functional and quantitative changes of CCR6+ type 3 innate lymphoid cells in murine collagen-induced arthritis.2016
- Author(s)
  Ayako Takaki, Yojiro Arinobu, Kensuke Irino, Hirofumi Tsuzuki, Yuri Ota, Daisuke Oryoji, Masahiro Ayano, Yashutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Hiroaki Niiro, Hiroshi Tsukamoto, Takahiko Horiuchi, and Koichi Akashi.
- Organizer
  2016 ACR/ARHP annual meeting
- Place of Presentation
  Washington, DC
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 関節リウマチの免疫学的異常に対するアバタセプトの経時的効果2016
- Author(s)
  三嶋耕司、新納宏昭、大田俊一郎、井上靖、吉澤誠司、吉澤滋、永野修司、西坂浩明、澤部琢哉、押領司健介、多田芳史、小山芳伸、三苫弘喜、赤星光輝、有信洋二郎、大塚毅、上田章、大田俊行、中島衡、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 関節リウマチ患者におけるトシリズマブの有効性および酸化ストレスマーカー変化量の検討ー 52週解析から得られた知見ー2015
- Author(s)
  新納宏昭、塚本浩、有信洋二郎、赤星光輝、三苫弘喜、押領司健介、井上靖、澤部琢哉、永野修司、西坂浩明、吉澤誠司、多田芳史、吉澤滋、大塚毅、上田章、中島衡、堀内孝彦、赤司浩一
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] Correlation between efficacy of tocilizumab and levels of oxidative stress markers in patients with rheumatoid arthritis: the 52-week analysis.2015
- Author(s)
  Hiroaki Niiro, Hiroshi Tsukamoto, Yojiro Arinobu, Mitsuteru Akahoshi, Hiroki Mitoma, Kensuke Oryoji, Yasushi Inoue, Takuya Sawabe, Shuji Nagano, Hiroaki Nishizaka, Seiji Yoshizawa, Yoshifumi Tada, Shigeru Yoshizawa, Takeshi Otsuka, Akira Ueda, Hitoshi Nakashima, Takahiko Horiuchi, Koichi Akashi
- Organizer
  2015 ACR/ARHP annual meeting
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 関節リウマチの骨破壊に寄与するRANKL 発現エフェクターB細胞の機能解析2015
- Author(s)
  廣崎友里、新納宏昭、大田俊一郎、植木尚子、中山剛志、三嶋耕司、猪口翔一朗、髙木綾子、中川仁、中野翔太、押領司大助、綾野雅宏、上田彰、久本仁美、田中淳、三苫弘喜、赤星光輝、有信洋二郎、山田久方、久木田明子、塚本浩、赤司浩一
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] Role of the chemokine receptor CXCR3 in the function of regulatory B cells in patients with SLE2015
- Author(s)
  Shun-ichiro Ota, Hiroaki Niiro, Naoko Ueki, Yuri Hirosaki, Hirofumi Tsuzuki, Siamak Jabbarzadeh-Tabrizi, Tsuyoshi Nakayama, Koji Mishima, Ayako Takaki, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto, Koichi Akashi
- Organizer
  2015 ACR/ARHP annual meeting
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2015-11-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] ADAMTS13活性低下を伴わないTMA2015
- Author(s)
  新納宏昭
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K09528
[Presentation] 関節リウマチ患者におけるトシリズマブの有効性および酸化ストレスマーカー変化量の検討　―中間解析から得られた知見 - (W4-4)2014
- Author(s)
  新納宏昭、塚本浩、有信洋二郎、赤星光輝、木本泰孝、藤健太郎、押領司健介、井上靖、澤部琢哉、永野修司、西坂浩明、吉澤誠司、多田芳史、吉澤滋、大塚毅、上田章、中島衡、堀内孝彦、赤司浩一
- Organizer
  第58回日本リウマチ学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] 健常人ならびにSLE患者における制御性B細胞の誘導メカニズムの検討2014
- Author(s)
  大田俊一郎、新納宏昭、植木尚子、廣崎友里、野田久美子、田中淳、綾野雅宏、上田彰、久本仁美、押領司大助、中川仁、中野翔太、上田尚靖、木本泰孝、赤星光輝、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第58回日本リウマチ学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] 全身性エリテマトーデス患者におけるGranzyme B産生B細胞の役割 (W10-1)2014
- Author(s)
  植木尚子、新納宏昭、大田俊一郎、廣崎友里、野田久美子、上田尚靖、田中淳、綾野雅宏、上田彰、久本仁美、押領司大助、中川仁、中野翔太、木本泰孝、赤星光輝、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第58回日本リウマチ学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] エフェクターB細胞2014
- Author(s)
  新納　宏昭
- Organizer
  第42回日本臨床免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] Elucidation of melecular mechanisms of Breg induction in autoimmune diseases2014
- Author(s)
  Shun-ichiro Ota, Hiroaki Niiro, Naoko Ueki, Yuri Hirosaki, Hirofumi Tsuzuki, Kumiko Noda, Siamak Jabbarzadeh-Tabrizi,Atsushi Tanaka, Hiroki Mitoma, Yojiro Arinobu, Mitsuteru Akahoshi, Hiroshi Tsukamoto, and Koichi Akashi.
- Organizer
  ACR annual meeting 2014
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] 健常人ならびにSLE患者B細胞におけるIRAK発現とその役割2011
- Author(s)
  新納宏昭, 他
- Organizer
  第55回日本リウマチ学会総会
- Place of Presentation
  神戸
- Year and Date
  2011-07-19
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] A vital role of CIN85 in Cblmediated regulation of B cell survival, growth and differentiation2010
- Author(s)
  Hiroaki Niiro, Siamak JabbarzadehTabrizi, Kumiko Noda, Yasushi Inoue, Yojiro Arinobu, Koichi Akashi
- Organizer
  2010 Keystone Symposia February
- Place of Presentation
  Taos Convention Center, Taos, New Mexico, USA
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] ヒトB細胞におけるIRAK発現調節と自己免疫疾患におけるその関与2010
- Author(s)
  新納宏昭、JabbarzadehTabrizi Siamak,相澤久美子、上田尚靖、押領司健介、三苫弘喜、井上靖、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第54回日本リウマチ学会総会
- Place of Presentation
  神戸
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] A vital role of CIN85 in Cbl-mediated regulation of B cell survival, growth and differentiation.2010
- Author(s)
  Niiro H, et al.
- Organizer
  2010 Keystone Symposia
- Place of Presentation
  Taos Convention Center, Taos, New Mexico, USA
- Year and Date
  2010-02-24
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] 抗原受容体シグナルによる正常ならびにSLE B細胞サブセットの生存の制御2009
- Author(s)
  新納宏昭、ジャバルザデタブリジシアマック、相澤久美子、三苫弘喜、井上靖、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第53回日本リウマチ学会総会
- Place of Presentation
  東京
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] Cb1のB細胞機能制御におけるCIN85の役割/A vital role of CIN85 in Cblmediated regulation of B cell functions2009
- Author(s)
  Hiroaki Niiro, Siamak JabbarzadehTabrizi, Kumiko Noda, Yasushi Inoue, Yojiro Arinobu, Shinji Shimoda, Eishi Baba, Tadayoshi Taniyama, Toshiro Hara, Koichi Akashi
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] Critical role of CIN85 in Cblmediated regulation of B cell function after antigen receptor stimulation2009
- Author(s)
  Hiroaki Niiro, Siamak JabbarzadehTabrizi, Kumiko Aizawa, Yasushi Inoue, Yojiro Arinobu, Koichi Akashi
- Organizer
  96th annual meeting AAI Immunology
- Place of Presentation
  Washington State Convention & Trade Center, Seattle, WA
- Year and Date
  2009-05-10
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] Critical role of CIN85 in Cbl-mediated regulation of B cell function after antigen receptor stimulation2009
- Author(s)
  Niiro H, et al.
- Organizer
  96^<th> annual meeting AAI Immunology 2009
- Place of Presentation
  Washington State Convention & Trade Center
- Year and Date
  2009-05-10
- Data Source
  KAKENHI-PROJECT-21591267
[Presentation] SLE B細胞機能異常における新規アダプター分子CIN85の関与2008
- Author(s)
  新納宏昭、ジャバルザデシアマック、有信洋二郎、小野伸之、赤司浩一
- Organizer
  第52回日本リウマチ学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-04-22
- Data Source
  KAKENHI-PROJECT-19591169
[Presentation] SLE B細胞機能異常における新規アダプター分子CIN85の関与2008
- Author(s)
  新納宏昭, 他
- Organizer
  第52回日本リウマチ学会総会・学術集会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2008-04-22
- Data Source
  KAKENHI-PROJECT-19591169
[Presentation] 新規アダプター分子CIN85によるヒトB細胞の機能制御機構2007
- Author(s)
  新納宏昭, 他
- Organizer
  第51回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-04-28
- Data Source
  KAKENHI-PROJECT-19591169
[Presentation] 新規アダプター分子CIN85によるヒトB 細胞の機能制御機構2007
- Author(s)
  新納宏昭、ジャバルザデシアマック、吉本五一、赤司浩一
- Organizer
  第51回日本リウマチ学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-04-28
- Data Source
  KAKENHI-PROJECT-19591169
[Presentation] 健常人ならびにSLE患者B細胞におけるIRAK-M発現とその機能
- Author(s)
  新納宏昭、ジャバルザデータブリッジシアマック、大田俊一郎、植木尚子、廣崎友里、野田久美子、上田尚靖、田中淳、上田彰、久本仁美、綾野雅宏、押領司大助、赤星光輝、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第57回日本リウマチ学会総会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] 健常人ならびにSLE患者における制御性B細胞の比較検討
- Author(s)
  大田俊一郎、新納宏昭、植木尚子、Siamak Jabbarzadeh-Tabrizi、野田久美子、上田尚靖、田中淳、上田彰、久本仁美、綾野雅宏、古川牧緒、井上靖、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第56回日本リウマチ学会総会•学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] Cblアダプター分子CIN85によるB細胞機能制御とSLE患者B細胞における役割
- Author(s)
  新納宏昭、Siamak Jabbarzadeh-Tabrizi、大田俊一郎、植木尚子、野田久美子、上田尚靖、田中淳、上田彰、綾野雅宏、久本仁美、古川牧緒、井上靖、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第56回日本リウマチ学会総会•学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] 健常人ならびにSLEにおけるgranzyme B産生制御性B細胞の比較検討
- Author(s)
  植木尚子、新納宏昭、大田俊一郎、廣崎友里、ジャバルザデータブリッジシアマック、野田久美子、上田尚靖、田中淳、綾野雅宏、上田彰、久本仁美、押領司大助、赤星光輝、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第57回日本リウマチ学会総会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] 抗BAFF抗体、TACI-Ig
- Author(s)
  新納宏昭
- Organizer
  第56回日本リウマチ学会総会•学術集会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24591450
[Presentation] 関節リウマチ患者と健常人におけるB細胞のRANKL発現の比較検討
- Author(s)
  廣崎友里、新納宏昭、大田俊一郎、植木尚子、綾野雅宏、赤星光輝、有信洋二郎、塚本浩、堀内孝彦、赤司浩一
- Organizer
  第41回日本臨床免疫学会総会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-24591450

1. AKASHI Koichi (80380385)

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2. Nakamura Seiji (60189040)

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20. TSUKAMOTO Hiroshi

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# of Collaborated Products: 1 results
38. 赤星光輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NIIRO Hiroaki 新納 宏昭

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自己免疫疾患におけるT-bet＋エフェクターB細胞の役割Principal Investigator

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Role of cytokine-producing effector B cells in autoimmune diseasesPrincipal Investigator

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Role of effector B cells and regulatory B cells in the pathogenesis of autoimmune diseasesPrincipal Investigator

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Identification of human regulatory B cells and their role in autoimmune diseasesPrincipal Investigator

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c-Cbl-interacting protein of 85 kDa(CIN85) regulates the function of autoreactive B cellsPrincipal Investigator

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c-Cbl-interacting protein of 85 kDa (CIN85) regulates the function of normal and autoimmune B cellsPrincipal Investigator

NIIRO Hiroaki 新納宏昭

[Book] 今日の治療指針　2019年版［デスク判］2019

[Book] 内科学第9版(好酸球増加症,組織球増殖症)2007