KATO Tomoko 加藤朋子

… Alternative Names

Kato Tomoko 加藤朋子

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Researcher Number	10638802
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 研究員 2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 主任研究員 2025: 国立研究開発法人国立成育医療研究センター, システム発生・再生医学研究部, 研究員
Affiliation (based on the past Project Information) *help	2024: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 研究員 2020 – 2022: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 研究員 2017 – 2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 2015 – 2018: 国立研究開発法人国立成育医療研究センター, システム発生・再生医学研究部, 研究員 2015: 国立研究開発法人国立成育医療研究センター, 研究所システム発生・再生医学研究部, 研究員 2014: 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Basic Section 43060:System genome science-related / General anatomy (including histology/embryology) / System genome science Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 44010:Cell biology-related / Basic Section 48040:Medical biochemistry-related / Endocrinology
Keywords	Principal Investigator CRISPR/Cas9 / ゲノム編集 / ノックアウトマウス / 性分化 / 卵巣 / 相同組換えによる修復 / HDR因子 / 相同組み換え / NHEJ抑制 / HDR亢進 … More / NHEJ抑制因子 / HDR亢進因子 / DNA修復 / スクリーニング / CRISPR-Cas9 / HDR / 相同組換え修復 / 遺伝子 / 発生・分化 / 発現制御 / 細胞・組織 / 転写カスケード / 生殖腺 / 卵巣形成 / 発現解析 / 卵巣分化 / 機能解析 / 転写因子 … More Except Principal Investigator iPS細胞 / 遺伝子交換 / 細胞融合 / 骨格筋細胞 / 肝細胞 / 心筋細胞 / 倍数性 / DNA組換え / 欠失導入 / HR / NHEJ / HDR / Cas12a / Cas9 / ゲノム編集 / 発生・分化 / 臨床 / 性分化 Less

細胞種により異なる倍数性の意義をiPS細胞モデルにより追究する
- Principal Investigator
  
  宮岡佑一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
相同組換えを促進する因子の同定とその応用による正確なゲノム編集ツールの開発Principal Investigator
- Principal Investigator
  
  加藤朋子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
マウスの交配のように自在なヒトiPS細胞間の遺伝子交換手法の開発
- Principal Investigator
  
  宮岡佑一郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of non-random genome editing technology for therapeutic applications
- Principal Investigator
  
  MIYAOKA Yuichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Screening for factors that enhance HDR by CRISPR-Cas9Principal Investigator
- Principal Investigator
  
  KATO-INUI Tomoko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Identification of a new gene for 46,XY disorders of sex development
- Principal Investigator
  
  Hasegawa Yukihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Tokyo Metropolitan Children's Medical Center (Department of Clinical Research)
Identification of transcription factors related to mouse ovarian differentiation and construction of transcription networkPrincipal Investigator
- Principal Investigator
  
  KATO Tomoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  National Center for Child Health and Development
The functional analysis of transcription factors and transcriptional co-factors related to embryonic female mouse gonadal differentiationPrincipal Investigator
- Principal Investigator
  
  Kato Tomoko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  System genome science
- Research Institution
  National Center for Child Health and Development

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book

[Book] ゲノム編集技術を応用した製品開発とその実用化2021
- Author(s)
  執筆者:96名（乾　雅史、乾ー加藤朋子（分担執筆））、技術情報協会
- Total Pages
  602
- Publisher
  技術情報協会
- ISBN
  9784861048272
- Data Source
  KAKENHI-PROJECT-19K06631
[Journal Article] PACT/PRKRA and p53 regulate transcriptional activity of DMRT12020
- Author(s)
  Fujitani K, Otomo A, Nagayama Y, Tachibana T, Kato R, Kawashima Y, Kodera Y, Kato T, Takada S, Tamura K, Takamatatsu N and Ito M.
- Journal Title
  
  Genetics and Molecular Biology
  
  Volume: 43
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06631
[Journal Article] Expression of progesterone receptor, estrogen receptors α and β, and kisspeptin in the hypothalamus during perinatal development of gonad-lacking steroidogenic factor-1 knockout mice2019
- Author(s)
  Ikeda Yayoi、Kato-Inui Tomoko、Tagami Ayako、Maekawa Mamiko
- Journal Title
  
  Brain Research
  
  Volume: 1712 Pages: 167-179
- DOI
  10.1016/j.brainres.2019.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08476, KAKENHI-PROJECT-19K06631
[Journal Article] Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken.2019
- Author(s)
  Yamashita S, Kataoka K, Yamamoto H, Kato T, Hara S, Yamaguchi K, Renard-Guillet C, Katou Y, Shirahige K, Ochi H, Ogino H, Uchida T, Inui M, Takada S, Shigenobu S, and Asahara H
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 12560-12560
- DOI
  10.1038/s41598-019-48979-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06631, KAKENHI-PROJECT-19K06672, KAKENHI-PROJECT-19K06689, KAKENHI-PROJECT-15H02560, KAKENHI-PROJECT-16H04794
[Journal Article] Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development.2018
- Author(s)
  Tsuji-Hosokawa A, Kashimada K, Kato T, Ogawa Y, Nomura R, Takasawa K, Lavery R, Coschiera A, Schiessinger D, Harley V, Takada S and Morio T.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 13263-13263
- DOI
  10.1038/s41598-018-31376-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21664
[Journal Article] Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair2018
- Author(s)
  Tomoko Kati-Inui, Gou Takahashi, Szuyin Hsu, Yuichiro Miyaoka
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 1 Issue: 9 Pages: 4677-4688
- DOI
  10.1093/nar/gky264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21664, KAKENHI-PROJECT-17H04993
[Journal Article] Mapping of a responsible region for sex reversal upstream of Sox9 by production of mice with serial deletion in a genomic locus.2018
- Author(s)
  Yuya Ogawa, Miho Terao, Satoshi Hara, Moe Tamano, Haruka Okayasu, Tomoko Kato, Shuji Takada.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 17514-17514
- DOI
  10.1038/s41598-018-35746-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07429, KAKENHI-PROJECT-16K21664
[Journal Article] A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1/Dio3 domain during embryonic development.2018
- Author(s)
  Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H and Takada S.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 27 Issue: 18 Pages: 3283-3292
- DOI
  10.1093/hmg/ddy235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21664, KAKENHI-PROJECT-17K18403
[Journal Article] CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46,XY gonadal dysgenesis observed in 9p24.3 deletion patients2017
- Author(s)
  Masafumi Inui, Moe Tamano, Tomoko Kato, Shuji Takada
- Journal Title
  
  BB Reports
  
  Volume: 9 Pages: 238-244
- DOI
  10.1016/j.bbrep.2017.01.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K18558, KAKENHI-PROJECT-16K21664
[Journal Article] Creation of mutant mice with megabase-sized deletions containing custom-designed breakpoints by means of the CRISPR/Cas9 system2017
- Author(s)
  Kato T, Hara S, Goto Y, Ogawa Y, Okayasu H, Kubota S, Tamano M, Terao M, Takada S
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1
- DOI
  10.1038/s41598-017-00140-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21664
[Journal Article] Utilization of the CRISPR/Cas9 system for the efficient production of mutant mice using crRNA/tracrRNA with Cas9 nickase and FokI-dCas92016
- Author(s)
  Terao M, Tamano M, Hara S, Kato T, Kinoshita M, Takada S
- Journal Title
  
  Exp. Anim.
  
  Volume: 65 Issue: 3 Pages: 275-283
- DOI
  10.1538/expanim.15-0116
- NAID
  130006882365
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21664
[Journal Article] Cord Blood-Derived Endothelial Colony-Forming Cell Function is Disrupted in Congenital Diaphragmatic Hernia2016
- Author(s)
  Hideshi Fujinaga, Hiroko Fujinaga, Nobuyuki Watanabe, Tomoko Kato, Moe Tamano, Miho Terao, Shuji Takada, Yushi Ito, Akihiro Umezawa, Masahiko Kuroda
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: 310 Issue: 11 Pages: 1143-1154
- DOI
  10.1152/ajplung.00357.2015
- NAID
  120005845870
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670493, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-15K15100, KAKENHI-PROJECT-16K21664
[Journal Article] Microinjection-based generation of mutant mice with a double mutation and a 0.5 Mb deletion in their genome by the CRISPR/Cas9 system2016
- Author(s)
  Hara S, Kato T, Goto Y, Kubota S, Tamano M, Terao M, Takada S
- Journal Title
  
  Journal of Reproduction and Development
  
  Volume: 62 Issue: 5 Pages: 531-536
- DOI
  10.1262/jrd.2016-058
- NAID
  130005431273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21664
[Journal Article] TALEN-mediated gene disruption on Y Chromosome reveals critical role of EIF2S3Y in mouse spermatogenesis2015
- Author(s)
  Matsubara Y, Kato T, Kashimada K, Tanaka H, Zhi Z, Ichinose S, Mizutani S, Morio T, Chiba T, Ito Y, Saga Y, Takada S and Asahara H
- Journal Title
  
  Stem cells and Development
  
  Volume: 24 Pages: 1164-1170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26870888
[Journal Article] Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas92015
- Author(s)
  Hara S, Tamano M , Yamashita S , Kato T, Saito T, Sakuma T, Yamamoto T, Inui M, Takada S
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 11221-11221
- DOI
  10.1038/srep11221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870888, KAKENHI-PROJECT-26870891
[Presentation] 高精度改変型Cas9によるHDR亢進因子の探索2022
- Author(s)
  小野　輝美、加藤　朋子、宮岡　佑一郎
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] CRISPR-Cas9による相同組換え修復(HDR)を亢進する因子の探索2022
- Author(s)
  加藤　朋子、宮岡　佑一郎
- Organizer
  日本ゲノム編集学会第7回大会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] CRISPR-Cas9システムを基盤とした相同組換えによる修復(HDR)亢進因子の新規探索2021
- Author(s)
  加藤　朋子
- Organizer
  第44回日本分子生物学会年会（横浜・オンラインのハイブリッド開催）
- Data Source
  KAKENHI-PROJECT-19K06631
[Presentation] CRISPR-Cas9システムを基盤とした相同組換えによる修復(HDR)亢進因子の新規探索2021
- Author(s)
  加藤　朋子、高橋　剛、宮岡　佑一郎
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] Genome editing via Cas9 RNP improves the HDR/NHEJ ratio2018
- Author(s)
  Tomoko Kato, Gou Takahashi, Szuyin Hsu, Yuichiro Miyaoka
- Organizer
  Cold Spring Harbor Laboratory Meeting (Genome Engineering: The CRISPR-Cas Revolution
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21664
[Presentation] Cas9リボ核タンパク質(RNP)を介したゲノム編集はHDR/NHEJ比を亢進する2018
- Author(s)
  加藤朋子、高橋剛、許絲茵、宮岡佑一郎
- Organizer
  日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-16K21664
[Presentation] Cas9とDNAの結合力がHDRとNHEJの活性を規定する2017
- Author(s)
  加藤朋子、高橋剛、許絲茵、宮岡佑一郎
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K21664
[Presentation] マウス軟骨・生殖腺特異的Sox9エンハンサーの同定と機能解析2015
- Author(s)
  加藤朋子、原聡史、玉野萌恵、小川湧也、岡安春佳、乾雅史、浅原弘嗣、高田修治
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会（BMB2015）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26870888
[Presentation] マウス胎仔期雌性生殖腺分化に関わる転写因子・転写コファクターの機能解析
- Author(s)
  加藤朋子、原聡史、玉野萌恵、秋元未来、乾雅史、浅原弘嗣、高田修治
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-26870888

1. MIYAOKA Yuichiro (20549521)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 高橋剛 (70802817)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. Hasegawa Yukihiro (70172898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高田修治 (20382856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 梅澤明弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 藤永英志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 池田やよい

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 池田正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 乾雅史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KATO Tomoko 加藤 朋子

Kato Tomoko 加藤 朋子

Research Projects

Research Products

Co-Researchers

細胞種により異なる倍数性の意義をiPS細胞モデルにより追究する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

相同組換えを促進する因子の同定とその応用による正確なゲノム編集ツールの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウスの交配のように自在なヒトiPS細胞間の遺伝子交換手法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of non-random genome editing technology for therapeutic applications

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Screening for factors that enhance HDR by CRISPR-Cas9Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of a new gene for 46,XY disorders of sex development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of transcription factors related to mouse ovarian differentiation and construction of transcription networkPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional analysis of transcription factors and transcriptional co-factors related to embryonic female mouse gonadal differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ゲノム編集技術を応用した製品開発とその実用化2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] PACT/PRKRA and p53 regulate transcriptional activity of DMRT12020

Author(s)

Journal Title

Data Source

[Journal Article] Expression of progesterone receptor, estrogen receptors α and β, and kisspeptin in the hypothalamus during perinatal development of gonad-lacking steroidogenic factor-1 knockout mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair2018

Author(s)

KATO Tomoko 加藤朋子

Kato Tomoko 加藤朋子