Sato Yusuke 佐藤悠介

… Alternative Names

SATO Yusuke 佐藤悠介

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Researcher Number	10735624
Other IDs
External Links
Affiliation (Current)	2022: 北海道大学, 薬学研究院, 助教
Affiliation (based on the past Project Information) *help	2016 – 2022: 北海道大学, 薬学研究院, 助教 2014 – 2015: 北海道大学, 薬学研究科(研究院), 特任助教 2014: 北海道大学, 大学院薬学研究院, 特任助教
Review Section/Research Field	Principal Investigator Physical pharmacy / Medical pharmacy / Biomedical engineering/Biomaterial science and engineering / Medium-sized Section 90:Biomedical engineering and related fields Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Drug development chemistry / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator siRNA / 脂質ナノ粒子 / 核酸送達 / 粒子径 / マイクロ流体デバイス / 脂質ナノキャリア / pH応答性 / 体内動態 / 細胞内動態 / PEG … More / デリバリー / がん浸透性 / 動態制御 / 薬物送達 / 粒径 / ゲノム編集 / in vivoゲノム編集 / RNP送達 / pH感受性カチオン性脂質 / 肝疾患治療 / ph感受性カチオン性脂質 / 安全治療域 / タンパク質送達 / RNP / In vivoゲノム編集 / RNA送達 / 足場構造 / 遺伝子ノックダウン / 粒径制御 / がん治療 / 組織浸透 … More Except Principal Investigator 核酸医薬 / 脂質ナノ粒子 / 組織標的化 / PSMA / オリゴヌクレオチド / ヌクレアーゼ抵抗性 / SPAAC / DNMT1 / stat3 / 核酸創薬 / 2'-OMe-4'-チオリポヌクレオシド / アンチマイクロRNA / shRNA / ホスホロチオエート結合 / ホスホジエステル結合 / 核酸ナノ医療 / 細胞内動態制御 / ナノDDS / がん免疫療法 / ミトコンドリア遺伝子治療 / siRNA / 細胞内局在 / 核酸送達 / 遺伝子治療 / ミトコンドリア / ナノＤＤＳ / 肝線維化 / TLL1 / TGFβ / miR-6133-5p / MEND / HCV / miRNA / LNP / 肝臓線維化 / ドラッグデリバリーシステム / 高分子ナノ粒子 / 精密重合 Less

Strategic creation of polymer-lipid hybrid nanoparticles for tissue-selective nucleic acid delivery
- Principal Investigator
  
  磯野拓也
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking steps
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Identification of novel therapeutic target for liver fibrosis and elucidation of the mechanism
- Principal Investigator
  
  Tanaka Yasuhito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
novel cancer treatment by highly permeable small-sized siRNA-loaded lipid nanoparticlesPrincipal Investigator
- Principal Investigator
  
  Sato Yusuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Development of lipid nanoparicles for treatment of hepatic diseases by in vivo genome editingPrincipal Investigator
- Principal Investigator
  
  Sato Yusuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Development of niucleic delivery system for targeting primary and metametastatic tumorPrincipal Investigator
- Principal Investigator
  
  SATO Yusuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
肝細胞標的siRNA送達システムの創製：体内動態と細胞内動態の真の両立Principal Investigator
- Principal Investigator
  
  佐藤悠介
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Targeting of the nuclease-resistant functional oligonucleotides
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2011

All Journal Article Presentation Book Patent

[Book] 医薬ジャーナル　2014年7月号(Vol.50 No.7)2014
- Author(s)
  佐藤悠介・中村孝司・山田勇磨・原島秀吉
- Total Pages
  200
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-26893001
[Book] Advances in Genetics Volume 88 Nonviral Vectors for Gene Therapy Lipid- and Polymer-based Gene Transfer2014
- Author(s)
  Sato Y, Nakamura T, Yamada Y, Akita H, Harashima H.
- Total Pages
  409
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-26893001
[Journal Article] Engineered ε-decalactone lipomers bypass the liver to selectively in vivo deliver mRNA to the lungs without targeting ligands2021
- Author(s)
  Elwakil A, Gao T, Isono T, Sato Y, Elewa Y, Satoh T, Harashima H,
- Journal Title
  
  Materials Horizons
  
  Volume: 8 Pages: 2251-2259
- DOI
  10.1039/d1mh00185j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20J20737
[Journal Article] The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines2021
- Author(s)
  Nakamura T, Nakade T, Yamada K, Sato Y, Harashima H
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 609 Pages: 121140-121140
- DOI
  10.1016/j.ijpharm.2021.121140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03373
[Journal Article] STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation2021
- Author(s)
  Nakamura T, Sato T, Endo R, Sasaki S, Takahashi N, Sato Y, Hyodo M, Hayakawa Y, Harashima H.
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 9
- DOI
  10.1136/jitc-2021-002852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03373
[Journal Article] Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations2021
- Author(s)
  Abbasi S, Higashino H, Sato Y, Minami K, Kataoka M, Yamashita S, Harashima H
- Journal Title
  
  Mol Pharm
  
  Volume: 18 Pages: 3181-3189
- DOI
  10.1021/acs.molpharmaceut.1c00197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution.2020
- Author(s)
  Nakamura Takashi, Kawai Minori, Sato Yusuke, Maeki Masatoshi, Tokeshi Manabu, Harashima Hideyoshi
- Journal Title
  
  Mol Pharm.
  
  Volume: 17 Pages: 944-953
- DOI
  10.1021/acs.molpharmaceut.9b01182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-18K19889, KAKENHI-PROJECT-19H01170
[Journal Article] Different Kinetics for the Hepatic Uptake of Lipid Nanoparticles Between the Apolipoprotein E/low Density Lipoprotein Receptor and the N-acetyl-d-galactosamine/asialoglycoprotein Receptor Pathway.2020
- Author(s)
  Hashiba A, Toyooka M, Sato Y, Maeki M, Tokeshi M, Harashima H.
- Journal Title
  
  J Control Release
  
  Volume: 327 Pages: 217-226
- DOI
  10.1016/j.jconrel.2020.08.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture2020
- Author(s)
  Hamada-Tsutsumi Susumu、Onishi Masaya、Matsuura Kentaro、Isogawa Masanori、Kawashima Keigo、Sato Yusuke、Tanaka Yasuhito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Pages: 7251-7251
- DOI
  10.3390/ijms21197251
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09435, KAKENHI-PROJECT-20K08313, KAKENHI-PROJECT-20K08314, KAKENHI-PROJECT-20K17028, KAKENHI-PROJECT-19H03640
[Journal Article] Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity2020
- Author(s)
  Nakamura T, Yamada K, Sato Y, Harashima H.
- Journal Title
  
  Int J Pharm.
  
  Volume: 587 Pages: 119652-119652
- DOI
  10.1016/j.ijpharm.2020.119652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles2020
- Author(s)
  Sato Y, Okabe N, Note Y, Hashiba K, Maeki M, Tokeshi M, Harashima H
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 102 Pages: 341-350
- DOI
  10.1016/j.actbio.2019.11.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.2019
- Author(s)
  Santiwarangkool S, Akita H, Khalil IA, Abd Elwakil MM, Sato Y, Kusumoto K, Harashima H.
- Journal Title
  
  J Control Release.
  
  Volume: 307 Pages: 55-63
- DOI
  10.1016/j.jconrel.2019.06.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution.2019
- Author(s)
  Nakamura Takashi, Yamada Yuma, Sato Yusuke, Khalil A Ikramy, Harashima Hideyoshi
- Journal Title
  
  Biomaterials.
  
  Volume: 218 Pages: 119329-119329
- DOI
  10.1016/j.biomaterials.2019.119329
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19888, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] Recent advances in the targeting of systemically administered non-viral gene delivery systems2019
- Author(s)
  Khalil IA, Sato Y, Harashima H.
- Journal Title
  
  Expert Opinion on Drug Delivery
  
  Volume: 16 Pages: 1037-1050
- DOI
  10.1080/17425247.2019.1656196
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo2019
- Author(s)
  Yusuke Sato, Kazuki Hashiba, Kosuke Sasaki, Masatoshi Maeki, Manabu Tokeshi, HIdeyoshi Harashima
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 295 Pages: 140-152
- DOI
  10.1016/j.jconrel.2019.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery2018
- Author(s)
  Niko Kimura, Masatoshi Maeki, Yusuke Sato, Yusuke Note, Akihiko Ishida, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi
- Journal Title
  
  ACS Omega
  
  Volume: 3 Pages: 5044-5041
- DOI
  10.1021/acsomega.8b00341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers2017
- Author(s)
  Maeki M, Fujishima Y, Sato Y, Yasui T, Kaji N, Ishida A, Tani H, Baba Y, Harashima H, Tokeshi M
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0187962
- NAID
  120006377541
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes2017
- Author(s)
  Hashiba K, Sato Y, Harashima H
- Journal Title
  
  J. Control. Release
  
  Volume: 262 Pages: 239-246
- DOI
  10.1016/j.jconrel.2017.07.046
- NAID
  120006523729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05052
[Journal Article] Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus2017
- Author(s)
  Sato Y, Matsui H, Yamamoto N, Sato R, Munakata T, Kohara M, Harashima H
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 266 Pages: 216-225
- DOI
  10.1016/j.jconrel.2017.09.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08871, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-15K19120
[Journal Article] Innovative Technologies in Nanomedicines: from Passive Targeting to Active Targeting / from Controlled Pharmacokinetics to Controlled Intracellular Pharmacokineticks2017
- Author(s)
  Sato Y, Sakurai Y, Kajimoto K, Nakamura T, Yamada Y, Akita H, Harashima H.
- Journal Title
  
  Macromolecular Biosciences
  
  Volume: 17 Pages: 1-16
- DOI
  10.1002/mabi.201600179
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26282132, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
[Journal Article] マイクロ流体デバイスによる脂質ナノ粒子作製とDDSへの応用2016
- Author(s)
  真栄城正寿, 佐藤悠介, 原島秀吉, 渡慶次学
- Journal Title
  
  機能材料
  
  Volume: 36 Pages: 15-21
- Data Source
  KAKENHI-PROJECT-15K20831
[Journal Article] Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery2016
- Author(s)
  Yusuke Sato, Yusuke Note, Masatoshi Maeki, Noritada Kaji, Yoshinobu Baba, Manabu Tokeshi, Hideyoshi Harashima
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 229 Pages: 48-57
- DOI
  10.1016/j.jconrel.2016.03.019
- NAID
  120006219995
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K20831
[Journal Article] Development of a multifunctional envelope-type nano device and its application to nanomedicine2016
- Author(s)
  Sato Y, Nakamura T, Yamada Y, Harashima H.
- Journal Title
  
  J Control Release.
  
  Volume: 244 Pages: 194-204
- DOI
  10.1016/j.jconrel.2016.06.042
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
[Journal Article] pH感受性脂質を基盤とした脂質ナノ粒子の開発と核酸ナノメディシンへの応用2016
- Author(s)
  佐藤悠介, 原島秀吉
- Journal Title
  
  化学工業
  
  Volume: 67 Pages: 21-27
- Data Source
  KAKENHI-PROJECT-15K20831
[Journal Article] Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells.2016
- Author(s)
  Yusuke Sato, Hiroto Hatakeyama, Mamoru Hyodo, Hideyoshi Harashima
- Journal Title
  
  Mol Ther.
  
  Volume: 24 Pages: 788-795
- DOI
  10.1038/mt.2015.222
- NAID
  120005906929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-26830101
[Journal Article] The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.2015
- Author(s)
  Sato S, Li K, Kameyama T, Hayashi T, Ishida Y, Murakami S, Watanabe T, Iijima S, Sakurai Y, Watashi K, Tsutsumi S, Sato Y, Akita H, Wakita T, Rice CM, Harashima H, Kohara M, Tanaka Y, Takaoka A
- Journal Title
  
  Immunity
  
  Volume: 42 Pages: 123-132
- DOI
  10.1016/j.immuni.2014.12.016
- NAID
  120005822521
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25253030, KAKENHI-PROJECT-25870015, KAKENHI-PROJECT-25893001, KAKENHI-PUBLICLY-26102747, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-26893001
[Journal Article] In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.2014
- Author(s)
  Watanabe T, Hatakeyama H, Matsuda-Yasui C, Sato Y, Sudoh M, Takagi A, Hirata Y, Ohtsuki T, Arai M, Inoue K, Harashima H, Kohara M
- Journal Title
  
  Sci Rep
  
  Volume: in press Pages: 4750-4750
- DOI
  10.1038/srep04750
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24590988, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25860305, KAKENHI-PROJECT-26893001
[Journal Article] Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain.2014
- Author(s)
  Tamaru M, Akita H, Nakatani T, Kajimoto K, Sato Y, Hatakeyama H, Harashima H.
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 9 Pages: 4267-4276
- DOI
  10.2147/ijn.s65402
- NAID
  120005476202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893001
[Journal Article] Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo.2014
- Author(s)
  Kazuaki Kajimoto, Yusuke Sato, Takashi Nakamura, Yuma Yamada, Hidesyoshi Harashima.
- Journal Title
  
  J Control Release
  
  Volume: 190 Pages: 593-606
- DOI
  10.1016/j.jconrel.2014.03.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26893001
[Journal Article] Selective transcription of an unnatural Naphthyridine:Imidazopyridopyrimidine base pair containing four hydrogen bonds with T7 RNA polymerase.2014
- Author(s)
  Nomura, Y.; Kashiwagi, S.; Sato, K.; Matsuda, A.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 53 Pages: 12844-12848
- DOI
  10.1002/anie.201406402
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-25410165
[Journal Article] The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.2014
- Author(s)
  Hiroto Hatakeyama, Manami Murata, Yusuke Sato, Mayumi Takahashi, Noriyuki Minakawa, Akira Matsuda, Hideyoshi Harashima
- Journal Title
  
  Journal of Controled Release
  
  Volume: 173 Pages: 43-50
- DOI
  10.1016/j.jconrel.2013.10.023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-23249008, KAKENHI-PUBLICLY-24107502, KAKENHI-PUBLICLY-24107518
[Journal Article] An apolipoprotein E modified liposomal nanoparticle : Ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells.2014
- Author(s)
  Mina Tamaru, Hidetaka Akita, Kazuaki Kajimoto, Yusuke Sato, Hiroto Hatakeyama, Hideyoshi Harashima
- Journal Title
  
  Int J Pharm
  
  Volume: 465 Pages: 77-82
- DOI
  10.1016/j.ijpharm.2014.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-11J05746, KAKENHI-PROJECT-26893001
[Journal Article] Highly Fluorescent 5-(5,6-Dimethoxy- benzothiazol-2-yl)-2'-Deoxyuridine 5'-Triphosphate as an Efficient Substrate for DNA Polymerases2011
- Author(s)
  Sato, K.
- Journal Title
  
  ChemBioChem
  
  Volume: 12 Pages: 2341-2346
- DOI
  10.1002/cbic.201100452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249008, KAKENHI-PROJECT-23750178
[Patent] 脂質ナノ粒子2022
- Inventor(s)
  佐藤悠介、原島秀吉、小沼はるの
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-060960
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 溶解剤2021
- Inventor(s)
  原島秀吉、佐藤悠介、アッバシ　サエド　アムジャド　ヨセフ、他
- Industrial Property Rights Holder
  国立大学法人北海道大学、常翔学園
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 代謝改善剤2021
- Inventor(s)
  西英一郎、岩﨑広高、大野美紀子、佐藤悠介、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2021
- Inventor(s)
  中村孝司、原島秀吉、佐藤悠介、山田小春、中出泰誠
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-023184
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2021
- Inventor(s)
  佐藤悠介、佐々木宏輔、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-085985
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2020
- Inventor(s)
  佐藤悠介、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2019
- Inventor(s)
  佐藤悠介, 原島秀吉, 渡慶次学, 真栄城正寿
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-101203
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H05052
[Patent] siRNA細胞内送達のための脂質膜構造体2018
- Inventor(s)
  原島秀吉, 佐藤悠介
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17H05052
[Patent] siRNA細胞内送達のための脂質膜構造体2017
- Inventor(s)
  原島秀吉, 佐藤悠介
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-117708
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17H05052
[Patent] 肝線維化修復剤2015
- Inventor(s)
  中島美紀, 小田祐輝, 原島秀吉, 佐藤悠介
- Industrial Property Rights Holder
  金沢大学, 北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-020308
- Filing Date
  2015-02-04
- Data Source
  KAKENHI-PROJECT-26893001
[Patent] 脂質膜構造体2014
- Inventor(s)
  原島秀吉, 佐藤悠介, など
- Industrial Property Rights Holder
  北海道大学, 公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-217011
- Filing Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-26893001
[Presentation] マイクロ流体デバイスによる脂質ナノ粒子の粒径制御とin vivo RNA送達2022
- Author(s)
  佐藤悠介, 奥田健斗, 岩川和樹, 佐々木宏輔, 原島秀吉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] マイクロ流体デバイスによる脂質ナノ粒子の粒径制御とin vivo RNA送達2022
- Author(s)
  佐藤悠介、奥田健斗、岩川和樹、佐々木宏輔、原島秀吉
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 脂質ナノ粒子の粒子径制御技術の確立と有用性の検討2021
- Author(s)
  奥田健斗, 佐藤悠介, 岩川和樹, 原島秀吉
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] mRNA ワクチンへの応用を目指した脂質ナノ粒子の粒子径制御技術の確立2021
- Author(s)
  奥田健斗, 佐藤悠介, 岩川和樹, 原島秀吉
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] 低温下での脂質ナノ粒子の免疫細胞表面への結合が引き起こすトランスフェクション活性の消失2021
- Author(s)
  中村孝司、山田小春、佐藤悠介、原島秀吉
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 脂質ナノ粒子の粒子径増大技術の確立とその有用性の検討2021
- Author(s)
  奥田健斗, 佐藤悠介, 岩川和樹, 原島秀吉
- Organizer
  日本薬学会北海道支部第148回例会
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] 機能性脂質を基盤とした脂質ナノ粒子製剤の開発とゲノム編集への応用2021
- Author(s)
  佐藤悠介
- Organizer
  第7回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 効率的かつ安全な高分子送達を可能とする脂質ナノ粒子製剤の開発2021
- Author(s)
  佐藤悠介
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 脂質ナノ粒子の特性がリンパ節送達とリンパ節内分布へ与える影響2020
- Author(s)
  中村孝司、河合美典、佐藤悠介、真栄城正寿、渡慶次学、原島秀吉
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] ゲノム編集タンパク質搭載脂質ナノ粒子の開発とHBV抑制効果の検証2020
- Author(s)
  佐藤悠介
- Organizer
  第27回次世代医工学研究会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Nucleic Acid Drugs and Nanomedicine: Multifunctional Envelope-type Nano Device for Nanomedicine2020
- Author(s)
  Hideyoshi Harashima, Yusuke Sato, Takashi Nakamura, Yuma Yamada
- Organizer
  The 79 Annual Meeting of the Japanese Cancer Association.
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Cas9-gRNA RNP搭載脂質ナノ粒子による高効率ゲノム編集2019
- Author(s)
  佐藤悠介, 鈴木裕一, 佐藤里咲, 真栄城正寿, 渡慶次学, 原島秀吉
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19889
[Presentation] Development of Ribonucleoprotein-loaded lipid nanoparticles for genome editing2019
- Author(s)
  Suzuki Y, Sato Y, Sato R, Maeki M, Tokeshi M, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] ゲノム編集タンパク質搭載脂質ナノ粒子の開発2019
- Author(s)
  佐藤悠介, 鈴木裕一, 佐藤里咲, 真栄城正寿, 渡慶次学, 原島秀吉
- Organizer
  日本核酸医薬学学会第5回年会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids.2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H.
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03640
[Presentation] 優れたsiRNA送達効率と安全性を両立する脂質ナノ粒子の開発2018
- Author(s)
  佐藤悠介, 橋場一毅, 原島秀吉.
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 効率的なin vivo核酸送達を実現する高機能脂質ナノ粒子2018
- Author(s)
  佐藤悠介, 橋場一毅, 原島秀吉.
- Organizer
  第27回インテリジェント材料・システムシンポジウム
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] siRNAデリバリーが可能な直径20 nmの極小脂質ナノ粒子の開発2018
- Author(s)
  岡部奈々, 佐藤悠介, 真栄城正寿, 渡慶次学, 原島秀吉
- Organizer
  日本薬学会北海道支部第145回例会
- Data Source
  KAKENHI-PROJECT-18K19889
[Presentation] Targeted delivery of siRNAs by manipulating acid dissociation constant of lipid nanoparticles2017
- Author(s)
  Shobaki N, Sato Y, Harashima H.
- Organizer
  The 5th International Life Science Symposium for Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 脂質ナノ粒子の膜酸乖離定数の操作による細胞選択的なsiRNA送達2017
- Author(s)
  ショバキヌレ, 佐藤悠介, 原島秀吉.
- Organizer
  第3回日本核酸医薬学会
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] メカニズムに基づいた安全性の高いsiRNA搭載脂質ナノ粒子の開発とB型肝炎治療への応用2017
- Author(s)
  佐藤悠介, 松井秀樹, 佐藤里咲, 原島秀吉
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] 機能性脂質を基盤としたin vivo核酸送達システムの開発2017
- Author(s)
  佐藤悠介.
- Organizer
  日本薬学会北海道支部主催第1回若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 肝臓標的型siRNA送達システムの安全性向上に関する検討2017
- Author(s)
  佐藤里咲, 佐藤悠介, 松井秀樹, 原島秀吉
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] 新規pH応答性脂質の開発による効率的なin vivo siRNAデリバリー2017
- Author(s)
  橋場一毅, 佐藤悠介, 原島秀吉.
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-17H05052
[Presentation] 肝臓を標的としたsiRNA搭載脂質ナノ粒子の物理化学的性質がsiRNA導入効率に及ぼす影響の評価2016
- Author(s)
  佐藤悠介, 野手雄介, ショバキヌレ, 原島秀吉
- Organizer
  第2回日本核酸医薬学会
- Place of Presentation
  東京理科大学（東京都葛飾区）
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] Optimizing siRNA delivery using specific multifunctional envelope-type nanodevice for liver sinusoidal endothelial cells2016
- Author(s)
  Shobaki N, Sato Y, Harashima H
- Organizer
  AsiaNANO 2016: Asian Conference on Nanoscience and Nanotechnology
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-10-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] pH応答性脂質ナノ粒子による肝実質細胞選択的なsiRNA導入とB型肝炎治療2015
- Author(s)
  佐藤悠介, 畠山浩人, 兵藤守, 山本直樹, 小原道法, 原島秀吉
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学（熊本県熊本市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] Elucidation of the physicochemical properties and potency for siRNA delivery of the siRNA-loaded small-sized nanoparticles2015
- Author(s)
  Yusuke Note, Yusuke Sato, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima
- Organizer
  The 18th Hokkaido University-Seoul National University Joint Sympojium
- Place of Presentation
  Seoul National University（韓国・ソウル）
- Year and Date
  2015-11-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20831
[Presentation] Development of siRNA delivery system for the treatment of hepatitis B viral infection2015
- Author(s)
  Yusuke Sato, Hiroto Hatakeyama, Naoki Yamamoto, Michinori Kohara, Hideyoshi Harashima
- Organizer
  The 18th Hokkaido University-Seoul National University Joint Sympojium
- Place of Presentation
  Seoul National University（韓国・ソウル）
- Year and Date
  2015-11-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20831

1. 原島秀吉 (00183567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. MATSUDA Akira (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. SATO Kosuke (70415686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Tanaka Yasuhito (90336694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 中村孝司 (20604458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. 山田勇磨 (60451431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. 大石久史 (30375513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 磯野拓也 (70740075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 佐藤敏文 (80291235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. WATANABE Tsunamasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. SATO Seiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. MATSUURA Kentarou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. KAJIMOTO Kazuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. HYOUDOU Mamoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. Abd Elwakil Mahmoud

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. 畠山浩人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 安井文彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 平田雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 小原道法

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 大槻貴博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 芫岡晃教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 櫻井遊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 渡士幸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 南川典昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 五十川正記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 棟方翼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 山本直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 秋田英万

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 喜多知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sato Yusuke 佐藤 悠介

SATO Yusuke 佐藤 悠介

Research Projects

Research Products

Co-Researchers

Strategic creation of polymer-lipid hybrid nanoparticles for tissue-selective nucleic acid delivery

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Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking steps

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Identification of novel therapeutic target for liver fibrosis and elucidation of the mechanism

Principal Investigator

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Review Section

Research Institution

novel cancer treatment by highly permeable small-sized siRNA-loaded lipid nanoparticlesPrincipal Investigator

Principal Investigator

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Review Section

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Development of lipid nanoparicles for treatment of hepatic diseases by in vivo genome editingPrincipal Investigator

Principal Investigator

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Development of niucleic delivery system for targeting primary and metametastatic tumorPrincipal Investigator

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肝細胞標的siRNA送達システムの創製：体内動態と細胞内動態の真の両立Principal Investigator

Principal Investigator

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Targeting of the nuclease-resistant functional oligonucleotides

Principal Investigator

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[Book] 医薬ジャーナル 2014年7月号(Vol.50 No.7)2014

Author(s)

Total Pages

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Data Source

[Book] Advances in Genetics Volume 88 Nonviral Vectors for Gene Therapy Lipid- and Polymer-based Gene Transfer2014

Author(s)

Total Pages

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Data Source

[Journal Article] Engineered ε-decalactone lipomers bypass the liver to selectively in vivo deliver mRNA to the lungs without targeting ligands2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines2021

Author(s)

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DOI

Data Source

[Journal Article] STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Maximizing the Oral Bioavailability of Poorly Water-Soluble Drugs Using Novel Oil-Like Materials in Lipid-Based Formulations2021

Author(s)

Sato Yusuke 佐藤悠介

SATO Yusuke 佐藤悠介

[Book] 医薬ジャーナル　2014年7月号(Vol.50 No.7)2014