HARASHIMA Hideyoshi 原島秀吉

… Alternative Names

Researcher Number	00183567
Other IDs
Affiliation (Current)	2019 : 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2019 : 北海道大学, 薬学研究科(研究院), 教授 2009 – 2014 : 北海道大学, 薬学研究科(研究院), 教授 2013 : 北海道大学, 薬学研究院, 教授 2006 – 2012 : 北海道大学, 大学院・薬学研究院, 教授 2011 : 北海道大学, 薬学研究科・研究院, 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / 応用薬理学・医療系薬学 / Biomedical engineering/Biological material science / Physical pharmacy / Science and Engineering / Physical pharmacy / Medical pharmacy / Drug development chemistry / Biological pharmacy / Medium-sized Section 90:Biomedical engineering and related fields … More Except Principal Investigator … More
Keywords	Principal Investigator GALA / トランスフェリン / MEND / エンドサイトーシス / 細胞内動態制御 / 薬物送達システム / 細胞内動態 / エンドソーム / リポソーム / がん … More Except Principal Investigator 脂質 / Glial-Derived Neurotrophic Factor / 薬物送達システム / リポソーム / 結核 / 核酸医薬 / ゲノム創薬 / HVJ-liposomes / ライソゾーム / 強心配糖体 / ヌクレアーゼ祇抗性核酸 / Na^+,K^+ ATPase / Liposome / 膜融合リポソーム / Isolated perfused heart / アプタマー / ウアバイン / オプソニン / Macrophage / 免疫学 / ワクチン / ヌクレアーゼ抵抗性核酸 / Complement receptor / 細菌 / Na^+,Ka^+ATPase / Lysosome / MEND / ホタルルシフェラーゼ / RNAi / 遺伝子の発現 / 膜透過性ペプチド / 血液脳関門 / 感染症 / Dicer / 心筋収縮力 / 機能性人工核酸 / 2'-O-メチル-4'-チオリボヌクレオシド / 補体 / K^+ATPase / DDS / Drug delivery system / 2'-0-メチル-4'-チオリポヌクレオシド / Na^+ / クリアランス / Glucose metabolism / パーキンソン病 / グルコース代謝 / 糖脂質 / Apo-B / 2型糖尿病 / ナノメディスン / ベクター / マクロピノサイトーシス / ミトコンドリア / ２型糖尿病 / Parkinson' disease / 薬物速度論 / ヌクレアーゼ抵抗性 / 遺伝子治療 / 脳毛細血管内皮細胞 / マクロファージ / 疾患モデルマウス / 薬物送達 / antisense RNA / マクロビノサイトーシス / miRNA / 2'-O-メチル-4'-チオリポヌクレオシド / NMR / 4'-チオ核酸 / SNALP / Na^+,K^+ATPase / Gene Therapy / ベンゾジアゼピンレセプター / Brain capillary endothelial cells / siRNA / si RNA / コレステロール / 補体レセプター / 細胞内運命 / Ouabain / 脳 / 4'-チオDNA / 2'-0-メチル-4'-チオリボヌクレオシド / in vivo / 心臓灌流実験 / リポソ-ム / RNA干渉 / Positive inotropic action / Blood-brain barrier / Cardiac glycosides / in vitro / ベンゾジアゼピン / Brain / Pharmacokinetics / Opsonin Less

律速段階の解明に基づいたウイルスを凌駕する革新的医薬分子送達システムの創製Principal InvestigatorOngoing
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
ＢＣＧ搭載ナノ粒子の細胞内動態制御に基づいた革新的膀胱癌治療システムの創製Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
MENDで拓く遺伝子治療への道：遺伝子の運び屋からナノマシンへPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Programmed Activationに基づく人工DNAワクチンの創製Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
Novel gene delivery system with switch functionPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides
- Principal Investigator
  
  SASAKI Shigeki
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyushu University
Developent of glycolipid vaccines against tuberculos is
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapyPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチンPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Development of multifunctional envelope-type nano device encapsulating highly nuclease resistant oligonucleotides
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and ratsPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
ミトコンドリアを標的とする多重型・多機能性エンベロープ型ナノ構造体の開発Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
2型糖尿病の遺伝子診断用候補遺伝子の網羅的解析及びその機能解析Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
臨床試験導入を目指した肝がん用in vivo高発現型人工遺伝子ベクターの開発Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Development of Multifunctional Envelope type Nano Device based on Programmed PackagingPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  HOKKAIDO UNIVERSITY
ゲノム機能情報に基づいた糖尿病薬の処方設計支援システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hokkaido University
選択的抗癌システムを目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング系の構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Optimization of pharmacokinetics and intracellular pharmacokinetics of viral and non-viral gene delivery systemPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング素の構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
核ターゲティングの新戦略:核膜の特殊性に基づいた標的化Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Intracellular control of transferrin-modified liposomes with Cholesteryl GALA for optimum drug delivery systemPrincipal Investigator
- Principal Investigator
  
  HIDEYOSHI Harashima
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
選択的抗腫瘍システムの開発を目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.
- Principal Investigator
  
  KOYABU Noriko, 松尾浩民
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokushima
核内転写制御による抗腫瘍効果を最適化するための細胞内動態制御システムの開発Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hokkaido University
  The University of Tokushima
Optimization of drug delivery system for antitumor agents based on the energy metabolism inhibition of tumor cellsPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokushima, Faculty of Pharmaceutical Sciences
Uptake mechanism and intracellular destiny of liposomes in RESPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima, Faculty of Pharmaceutical Sciences
Development of intracellular drug delivery system utilizing liposomes
- Principal Investigator
  
  KIWADA Hiroshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokushima
Kinetical analysis of pharmacodynamics based on drug-receptor interactions
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] Application of a fusiogenic peptide GALA for intracellular delivery2011
- Author(s)
  Nakase I, Kogure K, Harashima H, Futaki S
- Total Pages
  10
- Publisher
  Methods Mol Biol
- Data Source
  KAKENHI-PROJECT-22229001
[Book] Delivery of Nucleic Acids and Gene Delivery2011
- Author(s)
  H.Akita, H.Hatakeyama, I.A.Khalil, Y.Yamada, H.Harashima
- Total Pages
  34
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22229001
[Book] ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用-遺伝子医学MOOK別冊2011
- Author(s)
  山田勇磨、中村孝司、原島秀吉
- Total Pages
  8
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22229001
[Book] バイオテクノロジーシリーズ蛍光イメージング/MRIプローブの開発2011
- Author(s)
  秋田英万、山田勇磨,中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
- Total Pages
  10
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-22229001
[Book] Adv Biochem Eng Biotechnol(A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device.)2009
- Author(s)
  H.Hatakeyama, H.Akita, K.Kogure, H.Harashima
- Data Source
  KAKENHI-PROJECT-20015003
[Book] Contrib Nephrol (Nonviral gene delivery)2008
- Author(s)
  Akita H, Harashima H.
- Total Pages
  19
- Publisher
  KARGER
- Data Source
  KAKENHI-PROJECT-18200032
[Book] 分子薬物動態学(第17章高分子・遺伝子の体内動態の制御(細胞内動態を中心に))2008
- Author(s)
  秋田英万、原島秀吉
- Total Pages
  19
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-18200032
[Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy: Gene Design and Delivery Edit. by Kazunari Taira, Kazunori Kataoka,2005
- Author(s)
  H.Akita, I.A Khalil, K.Kogure, H.Harashima.
- Total Pages
  19
- Publisher
  Springer-Verlag Tokyo, Inc.
- Data Source
  KAKENHI-PROJECT-17659039
[Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller(Eds. Modern Biopharmaceuticals.)2005
- Author(s)
  K.Kogure, H.Akita, H.Kamiya, H.Harashima.
- Total Pages
  15
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-17016005
[Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy : Gene Design and Delivery(Edit. by Kazunari Taira, Kazunori Kataoka,)2005
- Author(s)
  H.Akita, I.A Khalil, K.Kogure, H.Harashima.
- Total Pages
  19
- Publisher
  Springer-Verlag Tokyo, Inc.
- Data Source
  KAKENHI-PROJECT-17016005
[Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller Eds. Modern Biopharmaceuticals.2005
- Author(s)
  K.Kogure, H.Akita, H.Kamiya, H.Harashima.
- Total Pages
  15
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity.2014
- Author(s)
  Nomura M, Hei-lay Z, Wang L, Morinaga H, Takayanagi R, Teramoto N
- Journal Title
  
  Mol. Ther. Nucleic Acids
  
  Volume : 57 Pages : 157-166
- DOI
  10.1007/s00125-013-3062-2
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02426, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23390247, KAKENHI-PROJECT-23591356, KAKENHI-PROJECT-26282148, KAKENHI-PROJECT-26461383
[Journal Article] A nanocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line2014
- Author(s)
  Yamada Y., Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S., Harashima H.
- Journal Title
  
  Biomaterials
  
  Volume : 35 Pages : 6430-6438
- DOI
  10.1016/j.biomaterials.2014.04.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-26461383
[Journal Article] RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system.2014
- Author(s)
  Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Noritaka Ohga, Kyoko Hida, Hideyoshi Harashima
- Journal Title
  
  Journal of Controlled Release
  
  Volume : 173 Pages : 110-118
- DOI
  10.1016/j.jconrel.2013.10.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25893001, KAKENHI-PROJECT-26830101
[Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, mincle2014
- Author(s)
  Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume : 289(22) Pages : 15405-12
- DOI
  10.1074/jbc.m114.566489
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-14J03573, KAKENHI-PROJECT-24390255, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213, KAKENHI-PROJECT-26860323, KAKENHI-PROJECT-25460543
[Journal Article] Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes2014
- Author(s)
  Yasuhiro Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato, Afsana Akhter, Yu Sakurai, Hiroto Hatakeyama, Mamoru Hyodo, Noritada Kaji, Yoshinobu Baba, Hideyoshi Harashima
- Journal Title
  
  Molecular Therapy ― Nucleic Acids
  
  Volume : 3
- DOI
  10.1038/mtna.2014.4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
[Journal Article] Investigation of siRNA nanoparticle formation using mono-cationic detergents and its use in gene silencing in human HeLa cells.2013
- Author(s)
  Yamada Y, Suzuki R, Harashima H.
- Journal Title
  
  Cancers.
  
  Volume : 5 Pages : 1413-25
- DOI
  10.3390/cancers5041413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication2013
- Author(s)
  Hossen MN, Kajimoto K, Akita H, Hyodo M, Harashima H.
- Journal Title
  
  J. Control. Release
  
  Volume : 171 Pages : 104-12
- DOI
  10.1016/j.jconrel.2013.07.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002
[Journal Article] The transfection activity of R8-modifiednanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine.2013
- Author(s)
  Toriyabe N, Hayashi Y, Harashima H.
- Journal Title
  
  Biomaterials
  
  Volume : 34 Pages : 1337-43
- DOI
  10.1016/j.biomaterials.2012.10.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23790038
[Journal Article] Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide2013
- Author(s)
  Eriko Kawamura, Yuma Yamada, Yukari Yasuzaki, Mamoru Hyodo and Hideyoshi Harashima.
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume : 116(5) Issue : 5 Pages : 634-637
- DOI
  10.1016/j.jbiosc.2013.05.001
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013
- Author(s)
  Toriyabe N, Hayashi Y, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume : 34(4) Pages : 1337-1343
- DOI
  10.1016/j.biomaterials.2012.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Determination of the Optimal Cell-Penetrating Peptide Sequence for Intestinal Insulin Delivery Based on Molecular Orbital Analysis with Self-Organizing Maps2013
- Author(s)
  Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
- Journal Title
  
  J. Pharm. Sci
  
  Volume : 102 Pages : 1008-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23590056, KAKENHI-PROJECT-23310075
[Journal Article] Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier.2013
- Author(s)
  Yamada Y, Harashima H.
- Journal Title
  
  Mitochondrion
  
  Volume : 13 Pages : 526-32
- DOI
  10.1016/j.mito.2012.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053
[Journal Article] A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence2013
- Author(s)
  Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, Harashima H.
- Journal Title
  
  Int J Pharm.
  
  Volume : 456 Pages : 195-201
- DOI
  10.1016/j.ijpharm.2013.07.068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-25462909
[Journal Article] Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques.2013
- Author(s)
  Morita D, Miyamoto A, Hattori Y, Komori T, Nakamura T, lgarashi T, Harashima H, Sugita M
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 441(1) Pages : 108-113
- DOI
  10.1016/j.bbrc.2013.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-24390255
[Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells,2013
- Author(s)
  Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
- Journal Title
  
  J. Pharm Sci.
  
  Volume : 102 Pages : 1008-1015
- DOI
  10.1002/jps.23442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-24659007, KAKENHI-PUBLICLY-24106731
[Journal Article] Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system2013
- Author(s)
  Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Harashima H
- Journal Title
  
  Mol. Ther.
  
  Volume : (印刷中) Pages : 1195-1203
- DOI
  10.1038/mt.2013.57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02352, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
[Journal Article] Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter2013
- Author(s)
  Kawamura E, Yamada Y, Harashima H.
- Journal Title
  
  Mitochondrion
  
  Volume : 13 Pages : 610-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002
[Journal Article] Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide2013
- Author(s)
  Akita H, Enoto K, Tanaka H, Harashima H
- Journal Title
  
  Molecular Therapy
  
  Volume : 21(2) Pages : 309-317
- DOI
  10.1038/mt.2012.235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Development of a novel drug delivery system consisting of an antitumor agent tocopheryl succinate2012
- Author(s)
  Hama S, Utsumi S, Fukuda Y, Nakayama K, Okamura Y, Tsuchiya H, Fukuzawa K, Harashima H, Kogure K
- Journal Title
  
  J Control Release
  
  Volume : 161(3) Pages : 843-851
- DOI
  10.1016/j.jconrel.2012.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23390014
[Journal Article] The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition2012
- Author(s)
  Furukawa R, Yamada Y, Matsushima Y, Goto Y-I, Harashima H.
- Journal Title
  
  FEBS Open Bio
  
  Volume : 2 Pages : 145-150
- DOI
  10.1016/j.fob.2012.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes2012
- Author(s)
  Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, N.Yui
- Journal Title
  
  Biomaterials
  
  Volume : 33 Pages : 3952-3958
- DOI
  10.1016/j.biomaterials.2012.01.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053, KAKENHI-PLANNED-23107004
[Journal Article] Stearylated INF7 Peptide enhances endosomal escape and gene expression of PEGylated nanoparticles both in vitro and in vivo2012
- Author(s)
  El-Sayed A, Masuda T, Akita H, Harashima H
- Journal Title
  
  J Pharm Sci
  
  Volume : 101(2) Pages : 879-882
- DOI
  10.1002/jps.22807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
[Journal Article] Effect of the Anchor in Polyethylene Glycol-Lipids on the Transfection Activity of PEGylated Cationic Liposomes Encapsulating DNA2012
- Author(s)
  Kusumoto K, Akita H, El-Sayed A, Harashima H
- Journal Title
  
  Biol Pharm Bull
  
  Volume : 35(4) Issue : 4 Pages : 445-448
- DOI
  10.1248/bpb.35.445
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
[Journal Article] Different Mechanisms for nanoparticle formation between pDNA and siRNA using polyrotaxane as the polycation2012
- Author(s)
  Y.Yamada, M.Hashida, T.Nomura, H.Harashima, Y Yamasaki, K.Kataoka, A.Yamashita, R.Katoono, N.Yui
- Journal Title
  
  ChemPysChem
  
  Volume : 13(5) Pages : 1161-1165
- DOI
  10.1002/cphc.201100800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PLANNED-23107004, KAKENHI-PROJECT-23680053
[Journal Article] Fabrication of functionalized double-lamellar multifunctional envelope-type nanodevices using a microfluidic chip with achaotic mixer array2012
- Author(s)
  Kitazoe K, Park YS, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
- Journal Title
  
  PLoS One
  
  Volume : 7(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter2012
- Author(s)
  Y.Yamada, H.Harashima
- Journal Title
  
  Biomaterials
  
  Volume : 33(5) Pages : 1589-1595
- DOI
  10.1016/j.biomaterials.2011.10.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system2012
- Author(s)
  G. Kanda, H. Ochiai, H. Harashima, and H. Kamiya
- Journal Title
  
  J.Biotechnol.
  
  Volume : 157(# 1) Pages : 41-101
- DOI
  10.1016/j.jbiotec.2011.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] A multifunctional envelope-type nano device for use in nanomedicine: concept and Applications.2012
- Author(s)
  Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H
- Journal Title
  
  Accounts of Chemical Research
  
  Volume : 45(7) Pages : 1113-1121
- DOI
  10.1021/ar200254s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PUBLICLY-24107502
[Journal Article] Noninvasive and efficient transdermal delivery of CpGoligodeoxynucleotide for cancer immunotherapy2011
- Author(s)
  Kigasawa K, Kajimoto K, Nakamura T, Hama S, Kanamura K, Harashima H, Kogure K
- Journal Title
  
  J Control Release
  
  Volume : 150(3) Pages : 256-265
- DOI
  10.1016/j.jconrel.2011.01.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Improving in Vivo Hepatic Transfection Activity by Controlling Intracellular Trafficking: The Function of GALA and Maltotriose2011
- Author(s)
  Akita H, Masuda T, Nishio T, Niikura K, Ijiro K, Harashima H
- Journal Title
  
  Mol. Pharmaceutics
  
  Volume : 8(4) Pages : 1436-1442
- DOI
  10.1021/mp200189s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22350076, KAKENHI-PROJECT-22655050, KAKENHI-PROJECT-22655059
[Journal Article] KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume : 32(26) Pages : 6342-6350
- DOI
  10.1016/j.biomaterials.2011.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22659006
[Journal Article] Dual imaging of mRNA and protein production : an investigation of the mechanism of heterogeneity in cationic lipid-mediated transgene expression2011
- Author(s)
  Akita H, Umetsu Y, Kurihara D, Harashima H
- Journal Title
  
  Int J Pharm
  
  Volume : 415(1-2) Pages : 218-220
- DOI
  10.1016/j.ijpharm.2011.05.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. Biochem2011
- Author(s)
  Hattori Y, Matsunaga I, Komori T, UrakawaT, Nakamura T, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
- Journal Title
  
  Biophys. Res. Commun
  
  Volume : 409(2) Pages : 304-307
- Data Source
  KAKENHI-PROJECT-21390304
[Journal Article] A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver2011
- Author(s)
  S. Fukunaga, G. Kanda, J. Tanase, H. Harashima, T. Ohyama, and H. Kamiya
- Journal Title
  
  Gene Ther
  
  Volume : (in press)
- DOI
  10.1038/gt.2011.127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system2011
- Author(s)
  H. Ochiai, H. Harashima, and H. Kamiya
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume : 112(# 5) Issue : 5 Pages : 432-434
- DOI
  10.1016/j.jbiosc.2011.07.001
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] Functional improvement of an I.RQ-PEG-MEND for delivering genes to the lung2011
- Author(s)
  Ishitsuka T, Akita H, Harashima H
- Journal Title
  
  J Control Release
  
  Volume : 154(1) Pages : 77-83
- DOI
  10.1016/j.jconrel.2011.05.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity2011
- Author(s)
  Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
- Journal Title
  
  J. Biol. Chem
  
  Volume : 286(19) Pages : 16800-16806
- Data Source
  KAKENHI-PROJECT-21390304
[Journal Article] Correction of Frameshift Mutations with Tailed Duplex DNAs2011
- Author(s)
  Y. Morita, H. Tsuchiya, H. Harashima, and H. Kamiya
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume : 34(# 9) Issue : 9 Pages : 1465-1468
- DOI
  10.1248/bpb.34.1465
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] KALA-modified multi-layered nano- particles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume : 32(26) Pages : 6342-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Cell penetrating peptide-mediated systemic siRNA delivery to the liver2011
- Author(s)
  Hayashi Y, Yamauchi J, Khalil IA, Kajimoto K, Akita H, Harashima H
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume : 419(1-2) Pages : 308-13
- DOI
  10.1016/j.ijpharm.2011.07.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23790038
[Journal Article] A touch-and-go lipid wrapping technique in microfluidic channels for rapid fabrication of multifunctional envelope-type gene delivery nanodevices2011
- Author(s)
  Kitazoe K, Wang J, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
- Journal Title
  
  Lab. Chip
  
  Volume : 11 Pages : 3256-3262
- DOI
  10.1039/c1lc20392d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23390014
[Journal Article] Dual Function MITO-Porter, a nano carrier integrating both effcient cytoplasmic delivery and mitochondrial macromolecule delivery2011
- Author(s)
  Yamada Yuma, Ryo Furukawa, Yukari Yasuzaki, Harashima Hideyoshi
- Journal Title
  
  Mol.Ther.
  
  Volume : 19 Pages : 1449-1456
- DOI
  10.1038/mt.2011.99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011
- Author(s)
  Hatakeyama H, Ito E, Yamamoto M, Akita H, Hayashi Y, Kajimoto K, Kaji N, Baba Y, Harashima H
- Journal Title
  
  Mol Ther
  
  Volume : 19(8) Pages : 1487-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines : Programmed endosomal escape and dissociation.2010
- Author(s)
  Akita H.; Kogure K.; Moriguchi R.; Nakamura Y.; Higashi T.; Nakamura T.; Serada S.; Fujimoto M.; Naka T.; Futaki S.; Harashima H.
- Journal Title
  
  J.Control.Release 143
  
  Pages : 311-317
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells.2010
- Author(s)
  Sato Y.; Hatakeyama H.; Harashima H.
- Journal Title
  
  Biol Pharm Bull. 33
  
  Pages : 1246-1249
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake.2010
- Author(s)
  Takara K.; Hatakeyama H.; Ohga N.; Hida K.; Harashima H.
- Journal Title
  
  Int J Pharm. 396
  
  Pages : 143-148
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009
- Author(s)
  Hatakeyama H.; Ito E.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
- Journal Title
  
  J Control Release. 139
  
  Pages : 127-132
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a steo-wise membrane fusion process.2009
- Author(s)
  H.Akita, A.Kudo, A.Minoura, M.Yamaguchi, IA.Khalil, R.Moriguchi, T.Masuda, R.Danev, K.Nagayama, K.Kogure, H.Harashima
- Journal Title
  
  Biomaterials 30
  
  Pages : 2940-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system.2009
- Author(s)
  Y.Sakurai, H.Hatakeyama, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages : 928-932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process2009
- Author(s)
  H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A. Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure and H. Harashima.
- Journal Title
  
  Biomaterials 30(15)
  
  Pages : 2940-9
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system.2009
- Author(s)
  Sakurai Y.; Hatakeyama H.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
- Journal Title
  
  Biol Pharm Bull. 32
  
  Pages : 928-932
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.2009
- Author(s)
  H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure, H. Harashima
- Journal Title
  
  Biomaterials 30(15)
  
  Pages : 2940-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009
- Author(s)
  H.Hatakeyama, E.Ito, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
- Journal Title
  
  J.Control.Release 139
  
  Pages : 127-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape.2009
- Author(s)
  El-Sayed A, Masuda T, Khalil I, Akita H, Harashima H.
- Journal Title
  
  J Control Release. 138(2)
  
  Pages : 160-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription.2009
- Author(s)
  Masuda T, Akita H, Niikura K, Nishio T, Ukawa M, Enoto K, Danev R, Nagayama K, Ijiro K, Harashima H.
- Journal Title
  
  Biomaterials 30(27)
  
  Pages : 4806-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine- and octalysine- modified nanoparticles have different modes of endosomal escape.2008
- Author(s)
  A.El-Sayed, IA.Khalil, K.Kogure, S.Futaki, H.Harashima
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages : 23450-23461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives.2008
- Author(s)
  K. Sasaki, S. Chaki, Y. Nakamura, K. Kogure, H. Hamada, M. Ueno, S. Futaki, H. Harashima
- Journal Title
  
  Anal Bioanal Chem 391(8)
  
  Pages : 2717-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes.2008
- Author(s)
  T.Nakamura, R.Moriguchi, K.Kogure, N.Shastri, H.Harashima
- Journal Title
  
  Mol.Ther. 16
  
  Pages : 1507-1514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergisitic action of pH-sensitive fusogenic peptide derivatives.2008
- Author(s)
  K.Sasaki, S.Chaki, Y.Nakamura, K.Kogure, H.Hamada, M.Ueno, S.Futaki, H.Harashima
- Journal Title
  
  Anal.Bioanal.Chem. 391
  
  Pages : 2717-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008
- Author(s)
  El-Sayed A.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
- Journal Title
  
  J Biol Chem. 283
  
  Pages : 23450-23461
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives. Anal.2008
- Author(s)
  Sasaki K.; Kogure K.; Chaki S.; Nakamura Y.; Hamada H.; Ueno M.; Futaki S.; Harashima H.
- Journal Title
  
  Bioanal.Chem. 391
  
  Pages : 2717-2727
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway.2008
- Author(s)
  D. Mudhakir, H. Akita, E. Tan, H. Harashima
- Journal Title
  
  J Control Release 125(2)
  
  Pages : 164-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008
- Author(s)
  A. El-Sayed, IA. Khalil, K. Kogure, S. Futaki, H. Harashima
- Journal Title
  
  J Biol Chem 283(34)
  
  Pages : 23450-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] DNA microarray analysis on type 2 diabetes-related genes co-regulated between white blood cells and liver of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biol.2007
- Author(s)
  Y. Hayashi, S. Iida, Y. Sato, A. Nakaya, A. Sawada, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
- Journal Title
  
  Pharm. Bull 30(4)
  
  Pages : 763-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA2007
- Author(s)
  Nakamura, Y. ; Kogure, K. ; Futaki, S. ; Harashima, H.
- Journal Title
  
  J. Cont. Rel. 119
  
  Pages : 360-367
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Tumor targeting of doxorubicin by anti MT1-MMP antibodymodified PEG liposomes.2007
- Author(s)
  Hatakeyama H.; Akita H.; Ishida E.; Hashimoto K.; Kobayashi H.; Aoki T.; Yasuda J.; Obata K.; Kikuchi H.; Ishida T.; Kiwada H.; Harashima H.
- Journal Title
  
  Int.J.Pharm. 342
  
  Pages : 194-200
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Octaarginine-modified envelope-type nanoparticles for gene delivery. Gene Therapy nanoparticles for gene delivery2007
- Author(s)
  I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, K. Kataoka, and H. Harashima
- Journal Title
  
  Gene Therapy 14(8)
  
  Pages : 682-9
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007
- Author(s)
  Nakamura Y.; Kogure K.; Futaki S.; Harashima H.
- Journal Title
  
  J.Cont.Rel. 119
  
  Pages : 360-367
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007
- Author(s)
  Y. Nakamura, K. Kogure, S. Futaki, H. Harashima
- Journal Title
  
  J. Cont. Rel. 119(3)
  
  Pages : 360-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature.2006
- Author(s)
  Iwasa A.; Akita H.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
- Journal Title
  
  BBA-Biomembranes 1758
  
  Pages : 713-720
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Evaluation of the nuclear delivery and intra-nuclear transcription of the plasmid DNA condensed with m (mu) and NLS- m by cytoplasmic and nuclear microinjection : comparative study with poly L-lysine.2006
- Author(s)
  H.Akita, M.Tanimoto, T.Masuda, K.Kogure, S.Futaki, H.Harashima.
- Journal Title
  
  J.Gen.Med. 8・2
  
  Pages : 198-206
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Non-linear pharmacodynamics in non-viral gene delivery system : Synergistic relationship between dose and nuclear transcription efficiency.2006
- Author(s)
  R.Moriguchi, K.Kogure, H.Harashima.
- Journal Title
  
  J.Cont.Re.l. 110・3
  
  Pages : 605-609
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006
- Author(s)
  I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
- Journal Title
  
  J.Biol.Chem. 281・6
  
  Pages : 3544-3551
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006
- Author(s)
  I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
- Journal Title
  
  J.Biol.Chem. 281・6
  
  Pages : 3544-5551
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.2006
- Author(s)
  Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
- Journal Title
  
  J.Pharm. Pharmacol. (in press)
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray.2006
- Author(s)
  S. Iida, Y. Sato, A. Nakaya, Y. Shinohara, Y. Hayashi, A. Sawada, H. Nagata, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
- Journal Title
  
  Biol. Pharm. Bull 29(12)
  
  Pages : 2451-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression2006
- Author(s)
  1. I. A Khalil, K. Kogure, S. Futaki, and H. Harashima
- Journal Title
  
  J. Biol. Chem. 281(6)
  
  Pages : 3544-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.2006
- Author(s)
  Hatakeyama H.; Akita H.; Kogure K.; Oishi M.; Nagasaki Y.; Kihira Y.; Ueno M.; Kobayashi H.; Kikuchi H.; Harashima H.
- Journal Title
  
  Gene Therapy 14
  
  Pages : 68-77
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.2005
- Author(s)
  Y.Yamada, Y.Shinohara, T.Kakudo, S.Chaki, S.Futaki, H.Kamiya, H.Harashima
- Journal Title
  
  Int.J.Pharm. 303
  
  Pages : 1-7
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Pharmacokinetics And Brain Uptake Of Lactoferrin In Rats.2005
- Author(s)
  B.Ji, J.Maeda, K.Inoue, H.Akita, H.Harashima, T.Suhara.
- Journal Title
  
  Life Sciences 78・8
  
  Pages : 851-855
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Kinetic analysys of protein production after DNA transfection.2005
- Author(s)
  Y.Yamada, H.Kamiya, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 299
  
  Pages : 34-40
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005
- Author(s)
  K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 296・1-2
  
  Pages : 142-150
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Biodistribution of octaarginine modified lisposomes in mice.2005
- Author(s)
  D.Mudhakir, H.Akita, I.A.Khalil, S.Futaki, H.Harashima.
- Journal Title
  
  Drug metabolism and Pharmacokinetics 20・4
  
  Pages : 275-281
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005
- Author(s)
  Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
- Journal Title
  
  Biol. Pharm. Bull. 28・10
  
  Pages : 1939-1942
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005
- Author(s)
  K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 296・1-2
  
  Pages : 142-150
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005
- Author(s)
  R.Moriguchi, K.Kogure H.Akita, S.Futaki, M.Miyagishi, K.Taira, H.Harashima
- Journal Title
  
  Int.J.Pharm. 301
  
  Pages : 277-285
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005
- Author(s)
  R.Moriguchi, K.Kogure H.Akila, S.Futaki, M.Miyagishi, K.Taira, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 301
  
  Pages : 277-285
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005
- Author(s)
  Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
- Journal Title
  
  Biol.Pharm.Bull. 28・10
  
  Pages : 1939-1942
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Evaluation of nuclear translocation and transcription of plasmid DNA condensed with protamine by microinjection : introduction of Nuclear Translocation score.2005
- Author(s)
  T.Masuda, H.Akita, H.Harashima.
- Journal Title
  
  FEBS Lett. 579・10
  
  Pages : 2143-2148
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article]
- Author(s)
  H.Akita, K.Kogure, R.Moriguchi, Y.Nakamura, T.Higashi, T.Nakamura, S.Serada, M.Fujimoto, T.Naka, S.Futaki, H.Harashima
- Journal Title
  
  J.Control.Release (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.
- Author(s)
  Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
- Journal Title
  
  J.Pharm.Pharmacol. (in press)
- Data Source
  KAKENHI-PROJECT-17016005
[Presentation] DNAマイクロアレイとin vivo siRNA送達システムの融合による新規2型糖尿病治療薬創出2013
- Author(s)
  末光永理奈、林泰弘、梶本和昭、佐藤悠介、Afsana Akhter、櫻井遊、畠山浩人、兵藤守、加地範匡、馬場嘉信、原島秀吉
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋 (ウインクあいち)
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] An approach to mitochondrial genesilencing by the mitochondrial delivery of anti-sense RNA2013
- Author(s)
  Y. Yamada, R. Furukawa, E. Kawamura, H. Harashima
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] ミトコンドリアを標的とした遺伝子発現制御の試み2013
- Author(s)
  山田勇磨、古川亮、原島秀吉.
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋 (ウインクあいち)
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] 膵β細胞株MIN6細胞を標的としたDDS, β-MENDの構築および核酸導入・機能発現の検証2013
- Author(s)
  田端麻衣、山田勇磨、安崎友香理、野村政壽、柴田篤志、佐々木茂樹、原島秀吉
- Organizer
  日本薬学会北海道支部第140回例会
- Place of Presentation
  札幌(札幌コンベンションセンター)
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides2013
- Author(s)
  E. Kawamura, Y. Yamada, H. Harashima
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] A new approach for innovative nanomedicine of type 2 diabetes in combination with DNA microarray and in vivo siRNA delivery2013
- Author(s)
  Suemitsu E, Hayashi Y, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Harashima H,
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] Technologies in Gene Delivery for Nanomedicines2012
- Author(s)
  Hideyoshi Harashima, Breakthrough
- Organizer
  FIP Centennial, 2012
- Place of Presentation
  Amsterdam, the Netherlands, Amsterdam RAI
- Year and Date
  2012-10-08
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 3rd Asian Biomaterials Congress
- Place of Presentation
  BEXCO Busan (Korea)(招待講演)
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Controlled Intracellular trafficking of Non-viral Vectors2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 14th Annual Meeting of ASGCT Scientific Symposium Gene & Cell Therapy Around the Globe : A Showcase of Asia
- Place of Presentation
  Washington State Convention & Trade Center (USA)(招待講演)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] DDS製剤の臨床応用への課題、DDS製剤の臨床応用を目指して2011
- Author(s)
  原島秀吉
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀(東京)(招待講演)
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  Joint Meeting of the Austrian and German Pharmaceutical Sciences
- Place of Presentation
  University of Innsbruck (Austria)(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] KALA-modified multi-layered nano particles as antigen gene carrier for MHC Class-I mediated antigen presentation in DNA vaccine approach2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yanashita A, Katoono R, Yui N, Harashima H
- Organizer
  38th Annual Meeting & Exposition of the Controlled Release Society (CRS)
- Place of Presentation
  Gaylord National Hotel and Convention Center (U.S.A.)
- Year and Date
  2011-08-02
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011
- Author(s)
  Harashima H
- Organizer
  Joint Meeting of the Austrian and German PharmaceuticalSciences
- Place of Presentation
  University of Innsbruck (Austria)(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011
- Author(s)
  原島秀吉
- Organizer
  第40回日本免疫学会学術集会関連分野セミナー
- Place of Presentation
  幕張メッセ(千葉)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery: Concept and Application for Nanomedicine2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  Joint Meeting of the Austrian and German Pharmaceutical Sciences
- Place of Presentation
  Innsbruck, Austria, University of Innsbruck
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] バイオイメージングで可視化するナノメディシンの世界～多機能性エンベロープ型ナノ構造体が拓く遺伝子治療への道～2011
- Author(s)
  原島秀吉
- Organizer
  第20回日本バイオイメージング学会学術集会
- Place of Presentation
  千歳科学技術大学(北海道)(招待講演)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011
- Author(s)
  原島秀吉
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Concept and Application of MEND2010
- Author(s)
  Hideyoshi Harashima, Nanotechnology for In Vivo Gene Delivery
- Organizer
  2010 FIP PSWC/AAPS Annual Meeting and Exposition, Short Course: Nanotechnology from A to Z: Achievement in Drug Delivery and Tissue Engineering
- Place of Presentation
  New Orleans, U. S. A. Ernest N. Morial Convention Center
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] 多機能性エンベロープ型ナノ構造体による次世代医薬への新たな展開2010
- Author(s)
  原島秀吉
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島招待講演
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] MENDで拓く創薬への道2010
- Author(s)
  原島秀吉
- Organizer
  金沢大学薬学シンポジウム2010創薬動態フォーラムin金沢
- Place of Presentation
  金沢大学角間キャンパス金沢招待講演
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application for nanomedicine2009
- Author(s)
  Hideyoshi Harashima
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  Centennial Hall Kyushu University, Fukuoka, Japan
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application of programmed packaging2009
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 8^<th> Cerebral Vascular Biology 2009
- Place of Presentation
  Sendai Excel Hotel Tokyu, Sendai, Japan
- Year and Date
  2009-07-01
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Multifunctional envelope-type nano device for non-viral gene delivery: Concept and application for nanomedicine2009
- Author(s)
  H. Harashima
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  Hakata, Japan(invited)
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Multifunctional envelope-type Nano Device for in vivo systemic delivery of siRNA2008
- Author(s)
  H. Harashima
- Organizer
  68th International Congres of FIP
- Place of Presentation
  Basel, Switzerland(invited)
- Year and Date
  2008-09-02
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Controlled Intracellular Trafficking of Non-viral Vector.2008
- Author(s)
  H.Harashima
- Organizer
  The 10th Annual Meeting of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy.
- Place of Presentation
  Seatle.Washington.USA
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] 血液サンプルを用いた2型糖尿病の遺伝子診断システムの開発2007
- Author(s)
  林泰弘、飯田慎也、中谷明弘、澤田章弘、加地範匡、紙谷浩之、馬場嘉信、原島秀吉
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  大宮(大宮ソニックシティ)
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  第23会日本DDS学会
- Place of Presentation
  熊本
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007
- Author(s)
  H.Harashima
- Organizer
  13th International Symposium on Recent Advances in Drug Delivery Systems
- Place of Presentation
  Salt Lake City.Utah.USA.
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] 血管内皮細胞標的化ペプチド搭載リポソームの細胞内取り込み機構の解析2007
- Author(s)
  秋田英万、ディッキー・ムダキュル、タン・エルダル、原島秀吉
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  大宮(大宮ソニックシティ)
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] A Multi-functional envelope type nano device as an anti-tumor gene delivery system2007
- Author(s)
  原島秀吉
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18015004
[Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007
- Author(s)
  H. Harashima
- Organizer
  13th International Symposium on Recent Advances in Drug Delivery Systems
- Place of Presentation
  Salt Lake City, Utah, USA.(invited)
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Cellular uptake mechanism and intracellular trafficking study of the novel C152-peptide-modified liposomes(C152-Lip)2007
- Author(s)
  ディッキームダキュル、秋田英万、タンエルダル、原島秀吉
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本(熊本日航ホテル)
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  第23回日本DDS学会永井賞受賞講演
- Place of Presentation
  熊本(invited)
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  日本薬学会第127年会(学術振興賞受賞講演)
- Place of Presentation
  富山(invited)
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Controlled Intracellular Trafficking of Non-viral Vector2007
- Author(s)
  H. Harashima
- Organizer
  The 10th Annual Meeing of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy
- Place of Presentation
  Seatle, Washington, USA
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines
- Author(s)
  Hideyoshi Harashima
- Organizer
  FIP Centennial, 2012
- Place of Presentation
  Amsterdam RAI, Amsterdam, The Netherland
- Invited
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Multifunctional Envelope-type Nano Device as gene delivery system for Nanomedicine
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 10th France - Japan DDS Symposium
- Place of Presentation
  Grande Hotel de Bordeaux, Bordeaux, France
- Invited
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery
- Author(s)
  Hideyoshi Harashima
- Organizer
  IBS 2012 15th International Biotechnology Symposium and Exhibition
- Place of Presentation
  EXCO Daegu, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines
- Author(s)
  Hideyoshi Harashima
- Organizer
  FIP Centennial, 2012
- Place of Presentation
  Amsterdam RAI (The Netherlands)
- Invited
- Data Source
  KAKENHI-PROJECT-22659006

1. KAMIYA Hiroyuki (10204629)

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2. AKITA Hidetaka (80344472)

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# of Collaborated Products : 31results
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20. SUZUKI Yousuke

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28. HAYASHI Yasuhiro (30548178)

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29. IGARASHI Tatuhiko (90467431)

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32. MIZUGUCHI Hiroyuki (50311387)

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57. 由井伸彦

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HARASHIMA Hideyoshi 原島 秀吉

原島 秀吉 ハラシマ ヒデヨシ

Research Projects

Research Products

Co-Researchers

律速段階の解明に基づいたウイルスを凌駕する革新的医薬分子送達システムの創製Principal InvestigatorOngoing

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ＢＣＧ搭載ナノ粒子の細胞内動態制御に基づいた革新的膀胱癌治療システムの創製Principal Investigator

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Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity

Principal Investigator

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MENDで拓く遺伝子治療への道：遺伝子の運び屋からナノマシンへPrincipal Investigator

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Programmed Activationに基づく人工DNAワクチンの創製Principal Investigator

Principal Investigator

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Novel gene delivery system with switch functionPrincipal Investigator

Principal Investigator

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Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides

Principal Investigator

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Developent of glycolipid vaccines against tuberculos is

Principal Investigator

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Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapyPrincipal Investigator

Principal Investigator

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抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチンPrincipal Investigator

Principal Investigator

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がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator

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Development of multifunctional envelope-type nano device encapsulating highly nuclease resistant oligonucleotides

Principal Investigator

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Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and ratsPrincipal Investigator

Principal Investigator

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HARASHIMA Hideyoshi 原島秀吉

原島秀吉ハラシマヒデヨシ