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HARASHIMA Hideyoshi  原島 秀吉

ORCIDConnect your ORCID iD *help
Researcher Number 00183567
Other IDs
Affiliation *help 2009 – 2014 : 北海道大学, 薬学研究科(研究院), 教授
2013 : 北海道大学, 薬学研究院, 教授
2006 – 2012 : 北海道大学, 大学院・薬学研究院, 教授
2011 : 北海道大学, 薬学研究科・研究院, 教授
2009 – 2011 : 北海道大学, 薬学研究院, 教授 … More
2010 : 北海道大学
2010 : 北海道大学, 大学院・農学研究院, 教授
2001 – 2009 : 北大, 薬学研究科(研究院), 教授
2006 : 北海道大学, 大学院薬学研究院, 教授
1999 – 2005 : 北海道大学, 大学院・薬学研究科, 教授
2000 : 北大, 薬学研究科, 教授
2000 : Hokkaido Univ., Faculty of Pharmaceutical Sciences, Prof., 薬学研究科, 教授
1997 – 1999 : 徳島大, 薬学部, 助教授
1997 – 1998 : 徳島大学, 薬学部, 助教授
1990 – 1995 : 徳島大学, 薬学部, 助教授
1987 : 東京大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / 応用薬理学・医療系薬学 / Biomedical engineering/Biological material science / Physical pharmacy / Science and Engineering / Physical pharmacy / Medical pharmacy / Drug development chemistry / Biological pharmacy
Except Principal Investigator
Physical pharmacy / Infectious disease medicine / Drug development chemistry / 応用薬理学・医療系薬学
Keywords
Principal Investigator
GALA / トランスフェリン / MEND / エンドサイトーシス / 薬物送達システム / 細胞内動態制御 / 細胞内動態 / エンドソーム / リポソーム / がん … More / siRNA / オクタアルギニン / 網羅的解析 / 遺伝子診断 / 2型糖尿病 / 遺伝子治療 / 遺伝子ベクター / 遺伝子デリバリー / endocytosis / 非ウイルスベクター / KALA / 核局在化シグナル / 耐性 / ハイドロダイナミクス法 / intracellular trafficking / レセプター / 多重型 / ワクチン / 人工遺伝子デリバリーシステム / ターゲティング / Drug delivery system / OLETFラット / 核内動態制御 / アデノウイルス / ミトコンドリア / 核移行シグナル / アジュバント / 抗腫瘍効果 / パッケージング / ウイルスベクター / 多機能性エンベロープ型ナノ構造体 / 定量的評価 / ソーティング / 分子シンクロナイゼーション / Liposomes / トランスサイトーシス / 遺伝子カテゴリー / カルパイン10 / 血管透過 / 細胞性免疫 / ライソゾーム / 遺伝子発現 / ナノパッケージング / Gene / アンチセンス / transcriptional efficiency / オプソニン / ステアリルオクタアルギニン / 癌 / Complement receptor / 飽和性 / 遺伝子デリバリーシステム / スイッチ / 機能性核酸 / 体内動態制御 / Diameter / トポロジー / 抗原提示 / 転写阻害 / 核送達 / PCR / gene delivery system / 核膜融合モデル / 遺伝子導入 / MHCクラス-I / 原子間顕微鏡 / リポリーム / スイツチ / DDS / マイクロ流路 / Tumor / リソリーム / 自己活性化システム / 人工遺伝子デリバリー / 抗がん剤 / シンクロナイゼーション / PPD-MEND / recycling / オルガネラターゲティング / 薬物速度論 / がん治療 / DNAワクチン / 粒子径 / 核膜 / ポリエチレンイミン / エンドソーム脱出 / 遺伝子デソバソー / ソーティング素子 / カベオラ / エンドサイドシス / 細胞内シグナル / pH-感受性カチオニック脂質 / transferrin liposomes / MMP / octaarginin / adeno-virus / 還元環境応答性 / programmed packaging / スイッチ機能 / 共焦点レーザー顕微鏡 / 細胞内ターゲティング / quantification / R8-NEND / Saturation / ナノ構造体 / PPD / 動写阻害 / Othuka Long-Evans Tokushima Fatty (OLETF)ラット / 樹状細胞 / 細胞透過性ペプチド / リサイクル / デリバリーシステム / ナノマシン / in vivo / トランスフェリン修飾リポソーム / MTS / 遺伝子 / エネルギー代謝 / ミトコンドリア送達 / IRO / 転写効率 / 補体レセプター / Pharmacokinetics / バイセル / Opsonin … More
Except Principal Investigator
脂質 / Glial-Derived Neurotrophic Factor / 薬物送達システム / リポソーム / 結核 / 核酸医薬 / ゲノム創薬 / HVJ-liposomes / ライソゾーム / 強心配糖体 / ヌクレアーゼ祇抗性核酸 / Na^+,K^+ ATPase / Liposome / 膜融合リポソーム / Isolated perfused heart / アプタマー / ウアバイン / オプソニン / Macrophage / 免疫学 / ワクチン / ヌクレアーゼ抵抗性核酸 / Complement receptor / 細菌 / Na^+,Ka^+ATPase / Lysosome / MEND / ホタルルシフェラーゼ / RNAi / 遺伝子の発現 / 膜透過性ペプチド / 血液脳関門 / 感染症 / Dicer / 心筋収縮力 / 機能性人工核酸 / 2'-O-メチル-4'-チオリボヌクレオシド / 補体 / K^+ATPase / DDS / Drug delivery system / 2'-0-メチル-4'-チオリポヌクレオシド / Na^+ / クリアランス / Glucose metabolism / パーキンソン病 / グルコース代謝 / 糖脂質 / Apo-B / 2型糖尿病 / ナノメディスン / ベクター / マクロピノサイトーシス / ミトコンドリア / 2型糖尿病 / Parkinson' disease / 薬物速度論 / ヌクレアーゼ抵抗性 / 遺伝子治療 / 脳毛細血管内皮細胞 / マクロファージ / 疾患モデルマウス / 薬物送達 / antisense RNA / マクロビノサイトーシス / miRNA / 2'-O-メチル-4'-チオリポヌクレオシド / NMR / 4'-チオ核酸 / SNALP / Na^+,K^+ATPase / Gene Therapy / ベンゾジアゼピンレセプター / Brain capillary endothelial cells / siRNA / si RNA / コレステロール / 補体レセプター / 細胞内運命 / Ouabain / 脳 / 4'-チオDNA / 2'-0-メチル-4'-チオリボヌクレオシド / in vivo / 心臓灌流実験 / リポソ-ム / RNA干渉 / Positive inotropic action / Blood-brain barrier / Cardiac glycosides / in vitro / ベンゾジアゼピン / Brain / Pharmacokinetics / Opsonin Less
  • Research Projects

    (34results)
  • Research Products

    (143results)
  • Co-Researchers

    (59People)
  •  BCG搭載ナノ粒子の細胞内動態制御に基づいた革新的膀胱癌治療システムの創製Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Hokkaido University
  •  Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity

    • Principal Investigator
      SUGITA Masahiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Infectious disease medicine
    • Research Institution
      Kyoto University
  •  MENDで拓く遺伝子治療への道:遺伝子の運び屋からナノマシンへPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  Programmed Activationに基づく人工DNAワクチンの創製Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Hokkaido University
  •  Novel gene delivery system with switch functionPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Hokkaido University
  •  Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides

    • Principal Investigator
      SASAKI Shigeki
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyushu University
  •  Developent of glycolipid vaccines against tuberculos is

    • Principal Investigator
      SUGITA Masahiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Infectious disease medicine
    • Research Institution
      Kyoto University
  •  Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapyPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチンPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Hokkaido University
  •  がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Development of multifunctional envelope-type nano device encapsulating highly nuclease resistant oligonucleotides

    • Principal Investigator
      MATSUDA Akira
    • Project Period (FY)
      2006 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Drug development chemistry
    • Research Institution
      Hokkaido University
  •  Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and ratsPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Hokkaido University
  •  がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  ミトコンドリアを標的とする多重型・多機能性エンベロープ型ナノ構造体の開発Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Hokkaido University
  •  2型糖尿病の遺伝子診断用候補遺伝子の網羅的解析及びその機能解析Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  臨床試験導入を目指した肝がん用in vivo高発現型人工遺伝子ベクターの開発Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Development of Multifunctional Envelope type Nano Device based on Programmed PackagingPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  ゲノム機能情報に基づいた糖尿病薬の処方設計支援システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Hokkaido University
  •  選択的抗癌システムを目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      Hokkaido University
  •  遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング系の構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Optimization of pharmacokinetics and intracellular pharmacokinetics of viral and non-viral gene delivery systemPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング素の構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  核ターゲティングの新戦略:核膜の特殊性に基づいた標的化Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Hokkaido University
  •  Intracellular control of transferrin-modified liposomes with Cholesteryl GALA for optimum drug delivery systemPrincipal Investigator

    • Principal Investigator
      HIDEYOSHI Harashima
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  選択的抗腫瘍システムの開発を目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Science and Engineering
    • Research Institution
      Hokkaido University
  •  Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.

    • Principal Investigator
      KOYABU Noriko, 松尾 浩民
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KYUSHU UNIVERSITY
  •  トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokushima
  •  核内転写制御による抗腫瘍効果を最適化するための細胞内動態制御システムの開発Principal Investigator

    • Principal Investigator
      原島 秀吉
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Hokkaido University
      The University of Tokushima
  •  Optimization of drug delivery system for antitumor agents based on the energy metabolism inhibition of tumor cellsPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokushima, Faculty of Pharmaceutical Sciences
  •  Uptake mechanism and intracellular destiny of liposomes in RESPrincipal Investigator

    • Principal Investigator
      HARASHIMA Hideyoshi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      The University of Tokushima, Faculty of Pharmaceutical Sciences
  •  Development of intracellular drug delivery system utilizing liposomes

    • Principal Investigator
      KIWADA Hiroshi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokushima
  •  Kinetical analysis of pharmacodynamics based on drug-receptor interactions

    • Principal Investigator
      HANANO Manabu
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      University of Tokyo

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

  • [Book] バイオテクノロジーシリーズ蛍光イメージング/MRIプローブの開発2011

    • Author(s)
      秋田英万、山田勇磨,中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
    • Total Pages
      10
    • Publisher
      CMC出版
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] Delivery of Nucleic Acids and Gene Delivery2011

    • Author(s)
      H.Akita, H.Hatakeyama, I.A.Khalil, Y.Yamada, H.Harashima
    • Total Pages
      34
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] Application of a fusiogenic peptide GALA for intracellular delivery2011

    • Author(s)
      Nakase I, Kogure K, Harashima H, Futaki S
    • Total Pages
      10
    • Publisher
      Methods Mol Biol
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用-遺伝子医学MOOK別冊2011

    • Author(s)
      山田勇磨、中村孝司、原島秀吉
    • Total Pages
      8
    • Publisher
      メディカルドゥ
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Book] Adv Biochem Eng Biotechnol(A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device.)2009

    • Author(s)
      H.Hatakeyama, H.Akita, K.Kogure, H.Harashima
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Book] Contrib Nephrol (Nonviral gene delivery)2008

    • Author(s)
      Akita H, Harashima H.
    • Total Pages
      19
    • Publisher
      KARGER
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Book] 分子薬物動態学(第17章高分子・遺伝子の体内動態の制御(細胞内動態を中心に))2008

    • Author(s)
      秋田英万、原島秀吉
    • Total Pages
      19
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy: Gene Design and Delivery Edit. by Kazunari Taira, Kazunori Kataoka,2005

    • Author(s)
      H.Akita, I.A Khalil, K.Kogure, H.Harashima.
    • Total Pages
      19
    • Publisher
      Springer-Verlag Tokyo, Inc.
    • Data Source
      KAKENHI-PROJECT-17659039
  • [Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller Eds. Modern Biopharmaceuticals.2005

    • Author(s)
      K.Kogure, H.Akita, H.Kamiya, H.Harashima.
    • Total Pages
      15
    • Publisher
      Wiley-VCH
    • Data Source
      KAKENHI-PROJECT-17659039
  • [Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller(Eds. Modern Biopharmaceuticals.)2005

    • Author(s)
      K.Kogure, H.Akita, H.Kamiya, H.Harashima.
    • Total Pages
      15
    • Publisher
      Wiley-VCH
    • Data Source
      KAKENHI-PROJECT-17016005
  • [Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy : Gene Design and Delivery(Edit. by Kazunari Taira, Kazunori Kataoka,)2005

    • Author(s)
      H.Akita, I.A Khalil, K.Kogure, H.Harashima.
    • Total Pages
      19
    • Publisher
      Springer-Verlag Tokyo, Inc.
    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] A nanocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line2014

    • Author(s)
      Yamada Y., Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S., Harashima H.
    • Journal Title

      Biomaterials

      Volume : 35 Issue : 24 Pages : 6430-6438

    • Publisher
      Elsevier
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-26461383
  • [Journal Article] Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes2014

    • Author(s)
      Hayashi Y., Suemitsu E., Kajimoto K., Sato Y., Akhter A., Sakurai Y., Hatakeyama H., Hyodo M., Kaji N., Baba Y., Harashima H
    • Journal Title

      Mol. Ther. Nucleic Acids

      Volume : 3 Pages : 157-166

    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23390247, KAKENHI-PROJECT-23591356, KAKENHI-PROJECT-26282148, KAKENHI-PROJECT-26461383, KAKENHI-PROJECT-12F02426
  • [Journal Article] RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system2014

    • Author(s)
      Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Ohga N, Hida K, Harashima H.
    • Journal Title

      Journal of controlled release

      Volume : 173 Pages : 110-118

    • Publisher
      Elsevier science bv
    • Year and Date
      2014-01-10
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25893001, KAKENHI-PROJECT-26830101, KAKENHI-PROJECT-11J05557
  • [Journal Article] Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes2014

    • Author(s)
      Hayashi Y, Suemitsu E, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Kaji N, Baba Y, Harashima H.
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume : 3 Pages : e154

    • Publisher
      Nature Publishing Group
    • Year and Date
      2014-03-18
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-11J05557
  • [Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle.2014

    • Author(s)
      Hattori Y, Morita D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M
    • Journal Title

      Journal of Biological Chemistry

      Volume : 289 Pages : 15405-15412

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390255, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213, KAKENHI-PROJECT-26860323, KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-14J03573, KAKENHI-PROJECT-25460543
  • [Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells2013

    • Author(s)
      Yuma Yamada, Kohei Nakamura, Ryo Furukawa, Eriko Kawamura, Takuya Moriwaki, Kenji Matsumoto, Katsuhiro Okuda, Mitsuru Shindo and Hideyoshi Harashima
    • Journal Title

      J. Pharm Sci.

      Volume : 102 Pages : 1008-1015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells2013

    • Author(s)
      Yamada Y., Nakamura K., Furukawa R., Kawamura E., Moriwaki T., Matsumoto K., Okuda K., Shindo M., Harashima H
    • Journal Title

      J. Pharm Sci

      Volume : 102 Pages : 1008-1015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-24659007, KAKENHI-PUBLICLY-24106731, KAKENHI-PROJECT-10J02273
  • [Journal Article] Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide2013

    • Author(s)
      Kawamura E, Yamada Y, Yasuzaki Y, Hyodo M, Harashima H.
    • Journal Title

      Journal of bioscience and bioengineering

      Volume : 116 Issue : 5 Pages : 634-637

    • Publisher
      Soc bioscience bioengineering japan
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-11J05438
  • [Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells2013

    • Author(s)
      Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
    • Journal Title

      J Pharm Sci. (Wiley)

      Volume : 102 Pages : 1008-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23310075
  • [Journal Article] Investigation of siRNA nanoparticle formation using mono-cationic detergents and its use in gene silencing in human HeLa cells2013

    • Author(s)
      Yamada Y, Suzuki R, Harashima H.
    • Journal Title

      Cancers (MDPI)

      Volume : 5 Pages : 1413-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
  • [Journal Article] Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter2013

    • Author(s)
      Kawamura E, Yamada Y, Harashima H.
    • Journal Title

      Mitochondrion

      Volume : 13 Pages : 610-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Journal Article] Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system2013

    • Author(s)
      Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Harashima H.
    • Journal Title

      Mol. Ther.

      Volume : 21 Pages : 1195-203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-10J02352
  • [Journal Article] Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier2013

    • Author(s)
      Yamada Y, Harashima H.
    • Journal Title

      Mitochondrion

      Volume : 13 Issue : 5 Pages : 526-532

    • Publisher
      Elsevier sci ltd
    • PMID
      info:pmid/23000575
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053
  • [Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013

    • Author(s)
      Toriyabe N, Hayashi Y, Harashima H
    • Journal Title

      Biomaterials

      Volume : 34(4) Pages : 1337-1343

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide2013

    • Author(s)
      Akita H, Enoto K, Tanaka H, Harashima H
    • Journal Title

      Molecular Therapy

      Volume : 21(2) Pages : 309-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication2013

    • Author(s)
      Hossen MN, Kajimoto K, Akita H, Hyodo M, Harashima H.
    • Journal Title

      Journal of controlled release

      Volume : 171 Issue : 2 Pages : 104-112

    • Publisher
      Elsevier science bv
    • PMID
      info:pmid/23871959
    • Year and Date
      2013-10-28
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013

    • Author(s)
      Toriyabe N, Hayashi Y, Harashima H.
    • Journal Title

      Biomaterials. (Elsevier)

      Volume : 34 Pages : 1337-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23790038
  • [Journal Article] A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence2013

    • Author(s)
      Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, Harashima H.
    • Journal Title

      International journal of pharmaceutics

      Volume : 456 Issue : 1 Pages : 195-201

    • Publisher
      Elsevier science bv
    • PMID
      info:pmid/23933440
    • Year and Date
      2013-11-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-25462909
  • [Journal Article] Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques.2013

    • Author(s)
      Morita D, Miyamoto A, Hattori Y, Komori T, Nakamura T, Igarashi T, Harashima H, Sugita M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume : 441 Pages : 108-113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390255, KAKENHI-PROJECT-12J04754
  • [Journal Article] Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes2012

    • Author(s)
      Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, N.Yui
    • Journal Title

      Biomaterials

      Volume : 33 Issue : 15 Pages : 3952-3958

    • Publisher
      Elsevier
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053, KAKENHI-PLANNED-23107004
  • [Journal Article] Fabrication of functionalized double-lamellar multifunctional envelope-type nanodevices using a microfluidic chip with achaotic mixer array2012

    • Author(s)
      Kitazoe K, Park YS, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
    • Journal Title

      PLoS One

      Volume : 7(6)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine: Concept and Applications2012

    • Author(s)
      Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H
    • Journal Title

      Acc Chem Res

      Volume : 45(7) Pages : 1113-1121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PUBLICLY-24107502
  • [Journal Article] The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition2012

    • Author(s)
      Furukawa R, Yamada Y, Matsushima Y, Goto Y, Harashima H
    • Journal Title

      FEBS Open Bio

      Volume : 2 Pages : 145-150

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-10J02273
  • [Journal Article] A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver.2012

    • Author(s)
      S. Fukunaga, G. Kanda, J. Tanase, H. Harashima, T. Ohyama, and H. Kamiya
    • Journal Title

      Gene therapy

      Volume : 19 Issue : 8 Pages : 828-835

    • Publisher
      Nature Publishing
    • PMID
      info:pmid/21918548
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system2012

    • Author(s)
      G. Kanda, H. Ochiai, H. Harashima, and H. Kamiya
    • Journal Title

      Journal of Biotechnology

      Volume : 157 Issue : 1 Pages : 7-11

    • Publisher
      Elsevier B.V.
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] Development of a Novel Drug Delivery System consisting of an Antitumor Agent Tocopheryl Succinate2012

    • Author(s)
      Hama S, Utsumi S, Fukuda Y, Nakayama K, Okamura Y, Tsuchiya H, Fukuzawa K, Harashima H, Kogure K
    • Journal Title

      Journal of Control release

      Volume : 161(3) Pages : 843-851

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23390014
  • [Journal Article] Effect of the Anchor in Polyethylene Glycol-Lipids on the Transfection Activity of PEGylated Cationic Liposomes Encapsulating DNA2012

    • Author(s)
      Kusumoto K, Akita H, El-Sayed A, Harashima H
    • Journal Title

      Biol Pharm Bull

      Volume : 35(4) Pages : 445-448

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-10F00421
  • [Journal Article] Stearylated INF7 Peptide enhances endosomal escape and gene expression of PEGylated nanoparticles both in vitro and in vivo2012

    • Author(s)
      El-Saved A, Masuda T, Akita H, Harashima H
    • Journal Title

      J Pharm Sci

      Volume : 101(2) Pages : 879-882

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-10F00421
  • [Journal Article] Different mechanisms for nanoparticle formation between pDNA and siRNA using Polyrotaxane as the polycation2012

    • Author(s)
      Y.Yamada, M.Hashida, T.Nomura, H.Harashima, Y Yamasaki, K.Kataoka, A.Yamashita, R.Katoono, N.Yui
    • Journal Title

      ChemPhysChem

      Volume : 13(5) Pages : 1161-1165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PLANNED-23107004, KAKENHI-PROJECT-23680053
  • [Journal Article] Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter.2012

    • Author(s)
      Y.Yamada, H.Harashima
    • Journal Title

      Biomaterials

      Volume : 33 Issue : 5 Pages : 1589-1595

    • Publisher
      Elsevier
    • PMID
      info:pmid/22105068
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
  • [Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011

    • Author(s)
      Hatakeyama H, Ito E, Yamamoto M, Akita H, Hayashi Y, Kajimoto K, Kaji N, Baba Y, Harashima H
    • Journal Title

      Mol Ther

      Volume : 19(8) Pages : 1487-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Journal Article] KALA-modified multi-layered nano- particles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
    • Journal Title

      Biomaterials

      Volume : 32(26) Pages : 6342-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Journal Article] KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
    • Journal Title

      Biomaterials

      Volume : 32(26) Pages : 6342-6350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22659006
  • [Journal Article] Correction of Frameshift Mutations with Tailed Duplex DNAs2011

    • Author(s)
      Y. Morita, H. Tsuchiya, H. Harashima, and H. Kamiya
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume : 34 Issue : 9 Pages : 1465-1468

    • Publisher
      Pharmaceutical Society of Japan
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. Biochem2011

    • Author(s)
      Hattori Y, Matsunaga I, Komori T, UrakawaT, Nakamura T, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
    • Journal Title

      Biophys. Res. Commun

      Volume : 409(2) Pages : 304-307

    • Data Source
      KAKENHI-PROJECT-21390304
  • [Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity2011

    • Author(s)
      Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
    • Journal Title

      J. Biol. Chem

      Volume : 286(19) Pages : 16800-16806

    • Data Source
      KAKENHI-PROJECT-21390304
  • [Journal Article] Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system2011

    • Author(s)
      H. Ochiai, H. Harashima, and H. Kamiya
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume : 112 Issue : 5 Pages : 432-434

    • Publisher
      Elsevier B.V.
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
  • [Journal Article] Noninvasive and efficient transdermal delivery of CpGoligodeoxynucleotide for cancer immunotherapy2011

    • Author(s)
      Kigasawa K, Kajimoto K, Nakamura T, Hama S, Kanamura K, Harashima H, Kogure K
    • Journal Title

      J Control Release

      Volume : 150(3) Pages : 256-265

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Functional improvement of an I.RQ-PEG-MEND for delivering genes to the lung2011

    • Author(s)
      Ishitsuka T, Akita H, Harashima H
    • Journal Title

      J Control Release

      Volume : 154(1) Pages : 77-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Improving in vivo hepatic transfection activity by controlling intracellular trafficking : the function of GALA and maltotriose2011

    • Author(s)
      Akita H, Masuda T, Nishio T, Niikura K, Ijiro K, Harashima H
    • Journal Title

      Mol Pharm

      Volume : 8(4) Pages : 1436-1442

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22350076, KAKENHI-PROJECT-22655050, KAKENHI-PROJECT-22655059
  • [Journal Article] Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery.2011

    • Author(s)
      Y.Yamada, R.Furukawa, Y.Yasuzaki, H.Harashima
    • Journal Title

      Molecular therapy : the journal of the American Society of Gene Therapy

      Volume : 19 Issue : 8 Pages : 1449-1456

    • Publisher
      Nature Publishing
    • PMID
      info:pmid/21694702
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-11J05438
  • [Journal Article] Cell penetrating peptide-mediated systemic siRNA delivery to the liver2011

    • Author(s)
      Hayashi Y, Yamauchi J, Khalil IA, Kajimoto K, Akita H, Harashima H
    • Journal Title

      International Journal of Pharmaceutics

      Volume : 419 Issue : 1-2 Pages : 308-313

    • Publisher
      Elsevier B.V.
    • Year and Date
      2011-10-31
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23790038
  • [Journal Article] A touch-and-go lipid wrapping technique in microfluidic channels for rapid fabrication of multifunctional envelope-type gene delivery nanodevices2011

    • Author(s)
      Kitazoe K, Wang J, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
    • Journal Title

      Lab Chip

      Volume : 11 Pages : 3256-3262

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Dual imaging of mRNA and protein production : an investigation of the mechanism of heterogeneity in cationic lipid-mediated transgene expression2011

    • Author(s)
      Akita H, Umetsu Y, Kurihara D, Harashima H
    • Journal Title

      Int J Pharm

      Volume : 415(1-2) Pages : 218-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines : Programmed endosomal escape and dissociation.2010

    • Author(s)
      Akita H.; Kogure K.; Moriguchi R.; Nakamura Y.; Higashi T.; Nakamura T.; Serada S.; Fujimoto M.; Naka T.; Futaki S.; Harashima H.
    • Journal Title

      J.Control.Release 143

      Pages : 311-317

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells.2010

    • Author(s)
      Sato Y.; Hatakeyama H.; Harashima H.
    • Journal Title

      Biol Pharm Bull. 33

      Pages : 1246-1249

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake.2010

    • Author(s)
      Takara K.; Hatakeyama H.; Ohga N.; Hida K.; Harashima H.
    • Journal Title

      Int J Pharm. 396

      Pages : 143-148

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system.2009

    • Author(s)
      Y.Sakurai, H.Hatakeyama, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages : 928-932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process2009

    • Author(s)
      H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A. Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure and H. Harashima.
    • Journal Title

      Biomaterials 30(15)

      Pages : 2940-9

    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape.2009

    • Author(s)
      El-Sayed A, Masuda T, Khalil I, Akita H, Harashima H.
    • Journal Title

      J Control Release. 138(2)

      Pages : 160-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a steo-wise membrane fusion process.2009

    • Author(s)
      H.Akita, A.Kudo, A.Minoura, M.Yamaguchi, IA.Khalil, R.Moriguchi, T.Masuda, R.Danev, K.Nagayama, K.Kogure, H.Harashima
    • Journal Title

      Biomaterials 30

      Pages : 2940-2949

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009

    • Author(s)
      Hatakeyama H.; Ito E.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
    • Journal Title

      J Control Release. 139

      Pages : 127-132

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system.2009

    • Author(s)
      Sakurai Y.; Hatakeyama H.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
    • Journal Title

      Biol Pharm Bull. 32

      Pages : 928-932

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.2009

    • Author(s)
      H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure, H. Harashima
    • Journal Title

      Biomaterials 30(15)

      Pages : 2940-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription.2009

    • Author(s)
      Masuda T, Akita H, Niikura K, Nishio T, Ukawa M, Enoto K, Danev R, Nagayama K, Ijiro K, Harashima H.
    • Journal Title

      Biomaterials 30(27)

      Pages : 4806-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009

    • Author(s)
      H.Hatakeyama, E.Ito, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
    • Journal Title

      J.Control.Release 139

      Pages : 127-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes.2008

    • Author(s)
      T.Nakamura, R.Moriguchi, K.Kogure, N.Shastri, H.Harashima
    • Journal Title

      Mol.Ther. 16

      Pages : 1507-1514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergisitic action of pH-sensitive fusogenic peptide derivatives.2008

    • Author(s)
      K.Sasaki, S.Chaki, Y.Nakamura, K.Kogure, H.Hamada, M.Ueno, S.Futaki, H.Harashima
    • Journal Title

      Anal.Bioanal.Chem. 391

      Pages : 2717-2727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Octaarginine- and octalysine- modified nanoparticles have different modes of endosomal escape.2008

    • Author(s)
      A.El-Sayed, IA.Khalil, K.Kogure, S.Futaki, H.Harashima
    • Journal Title

      J.Biol.Chem. 283

      Pages : 23450-23461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives. Anal.2008

    • Author(s)
      Sasaki K.; Kogure K.; Chaki S.; Nakamura Y.; Hamada H.; Ueno M.; Futaki S.; Harashima H.
    • Journal Title

      Bioanal.Chem. 391

      Pages : 2717-2727

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008

    • Author(s)
      El-Sayed A.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
    • Journal Title

      J Biol Chem. 283

      Pages : 23450-23461

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives.2008

    • Author(s)
      K. Sasaki, S. Chaki, Y. Nakamura, K. Kogure, H. Hamada, M. Ueno, S. Futaki, H. Harashima
    • Journal Title

      Anal Bioanal Chem 391(8)

      Pages : 2717-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway.2008

    • Author(s)
      D. Mudhakir, H. Akita, E. Tan, H. Harashima
    • Journal Title

      J Control Release 125(2)

      Pages : 164-173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008

    • Author(s)
      A. El-Sayed, IA. Khalil, K. Kogure, S. Futaki, H. Harashima
    • Journal Title

      J Biol Chem 283(34)

      Pages : 23450-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine-modified envelope-type nanoparticles for gene delivery. Gene Therapy nanoparticles for gene delivery2007

    • Author(s)
      I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, K. Kataoka, and H. Harashima
    • Journal Title

      Gene Therapy 14(8)

      Pages : 682-9

    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007

    • Author(s)
      Nakamura Y.; Kogure K.; Futaki S.; Harashima H.
    • Journal Title

      J.Cont.Rel. 119

      Pages : 360-367

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Tumor targeting of doxorubicin by anti MT1-MMP antibodymodified PEG liposomes.2007

    • Author(s)
      Hatakeyama H.; Akita H.; Ishida E.; Hashimoto K.; Kobayashi H.; Aoki T.; Yasuda J.; Obata K.; Kikuchi H.; Ishida T.; Kiwada H.; Harashima H.
    • Journal Title

      Int.J.Pharm. 342

      Pages : 194-200

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007

    • Author(s)
      Y. Nakamura, K. Kogure, S. Futaki, H. Harashima
    • Journal Title

      J. Cont. Rel. 119(3)

      Pages : 360-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] DNA microarray analysis on type 2 diabetes-related genes co-regulated between white blood cells and liver of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biol.2007

    • Author(s)
      Y. Hayashi, S. Iida, Y. Sato, A. Nakaya, A. Sawada, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
    • Journal Title

      Pharm. Bull 30(4)

      Pages : 763-771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA2007

    • Author(s)
      Nakamura, Y. ; Kogure, K. ; Futaki, S. ; Harashima, H.
    • Journal Title

      J. Cont. Rel. 119

      Pages : 360-367

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006

    • Author(s)
      I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
    • Journal Title

      J.Biol.Chem. 281・6

      Pages : 3544-5551

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.2006

    • Author(s)
      Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
    • Journal Title

      J.Pharm. Pharmacol. (in press)

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray.2006

    • Author(s)
      S. Iida, Y. Sato, A. Nakaya, Y. Shinohara, Y. Hayashi, A. Sawada, H. Nagata, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
    • Journal Title

      Biol. Pharm. Bull 29(12)

      Pages : 2451-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature.2006

    • Author(s)
      Iwasa A.; Akita H.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
    • Journal Title

      BBA-Biomembranes 1758

      Pages : 713-720

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.2006

    • Author(s)
      Hatakeyama H.; Akita H.; Kogure K.; Oishi M.; Nagasaki Y.; Kihira Y.; Ueno M.; Kobayashi H.; Kikuchi H.; Harashima H.
    • Journal Title

      Gene Therapy 14

      Pages : 68-77

    • Data Source
      KAKENHI-PROJECT-18109001
  • [Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression2006

    • Author(s)
      1. I. A Khalil, K. Kogure, S. Futaki, and H. Harashima
    • Journal Title

      J. Biol. Chem. 281(6)

      Pages : 3544-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006

    • Author(s)
      I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
    • Journal Title

      J.Biol.Chem. 281・6

      Pages : 3544-3551

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Non-linear pharmacodynamics in non-viral gene delivery system : Synergistic relationship between dose and nuclear transcription efficiency.2006

    • Author(s)
      R.Moriguchi, K.Kogure, H.Harashima.
    • Journal Title

      J.Cont.Re.l. 110・3

      Pages : 605-609

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Evaluation of the nuclear delivery and intra-nuclear transcription of the plasmid DNA condensed with m (mu) and NLS- m by cytoplasmic and nuclear microinjection : comparative study with poly L-lysine.2006

    • Author(s)
      H.Akita, M.Tanimoto, T.Masuda, K.Kogure, S.Futaki, H.Harashima.
    • Journal Title

      J.Gen.Med. 8・2

      Pages : 198-206

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005

    • Author(s)
      R.Moriguchi, K.Kogure H.Akila, S.Futaki, M.Miyagishi, K.Taira, H.Harashima.
    • Journal Title

      Int.J.Pharm. 301

      Pages : 277-285

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.2005

    • Author(s)
      Y.Yamada, Y.Shinohara, T.Kakudo, S.Chaki, S.Futaki, H.Kamiya, H.Harashima
    • Journal Title

      Int.J.Pharm. 303

      Pages : 1-7

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005

    • Author(s)
      K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
    • Journal Title

      Int.J.Pharm. 296・1-2

      Pages : 142-150

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005

    • Author(s)
      Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
    • Journal Title

      Biol. Pharm. Bull. 28・10

      Pages : 1939-1942

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Kinetic analysys of protein production after DNA transfection.2005

    • Author(s)
      Y.Yamada, H.Kamiya, H.Harashima.
    • Journal Title

      Int.J.Pharm. 299

      Pages : 34-40

    • Data Source
      KAKENHI-PROJECT-17659039
  • [Journal Article] Biodistribution of octaarginine modified lisposomes in mice.2005

    • Author(s)
      D.Mudhakir, H.Akita, I.A.Khalil, S.Futaki, H.Harashima.
    • Journal Title

      Drug metabolism and Pharmacokinetics 20・4

      Pages : 275-281

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Pharmacokinetics And Brain Uptake Of Lactoferrin In Rats.2005

    • Author(s)
      B.Ji, J.Maeda, K.Inoue, H.Akita, H.Harashima, T.Suhara.
    • Journal Title

      Life Sciences 78・8

      Pages : 851-855

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005

    • Author(s)
      R.Moriguchi, K.Kogure H.Akita, S.Futaki, M.Miyagishi, K.Taira, H.Harashima
    • Journal Title

      Int.J.Pharm. 301

      Pages : 277-285

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005

    • Author(s)
      K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
    • Journal Title

      Int.J.Pharm. 296・1-2

      Pages : 142-150

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Evaluation of nuclear translocation and transcription of plasmid DNA condensed with protamine by microinjection : introduction of Nuclear Translocation score.2005

    • Author(s)
      T.Masuda, H.Akita, H.Harashima.
    • Journal Title

      FEBS Lett. 579・10

      Pages : 2143-2148

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005

    • Author(s)
      Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
    • Journal Title

      Biol.Pharm.Bull. 28・10

      Pages : 1939-1942

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Journal Article]

    • Author(s)
      H.Akita, K.Kogure, R.Moriguchi, Y.Nakamura, T.Higashi, T.Nakamura, S.Serada, M.Fujimoto, T.Naka, S.Futaki, H.Harashima
    • Journal Title

      J.Control.Release (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.

    • Author(s)
      Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
    • Journal Title

      J.Pharm.Pharmacol. (in press)

    • Data Source
      KAKENHI-PROJECT-17016005
  • [Presentation] A new approach for innovative nanomedicine of type 2 diabetes in combination with DNA microarray and in vivo siRNA delivery2013

    • Author(s)
      Suemitsu E, Hayashi Y, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Harashima H,
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] 膵β細胞株MIN6細胞を標的としたDDS, β-MENDの構築および核酸導入・機能発現の検証2013

    • Author(s)
      田端麻衣、山田勇磨、 安崎友香理、野村政壽、柴田篤志、佐々木茂樹、原島秀吉
    • Organizer
      日本薬学会北海道支部第140回例会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] ミトコンドリアを標的とした遺伝子発現制御の試み2013

    • Author(s)
      山田勇磨、 古川亮、原島秀吉.
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋 (ウインクあいち)
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] DNAマイクロアレイとin vivo siRNA送達システムの融合による新規2型糖尿病治療薬創出2013

    • Author(s)
      末光永理奈、林泰弘、梶本和昭、佐藤悠介、Afsana Akhter、櫻井遊、畠山浩人、兵藤守、加地範匡、馬場嘉信、原島秀吉
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋 (ウインクあいち)
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides2013

    • Author(s)
      E. Kawamura, Y. Yamada, H. Harashima
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] An approach to mitochondrial genesilencing by the mitochondrial delivery of anti-sense RNA2013

    • Author(s)
      Y. Yamada, R. Furukawa, E. Kawamura, H. Harashima
    • Organizer
      40th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-21229002
  • [Presentation] Technologies in Gene Delivery for Nanomedicines2012

    • Author(s)
      Hideyoshi Harashima, Breakthrough
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam, the Netherlands, Amsterdam RAI
    • Year and Date
      2012-10-08
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery: Concept and Application for Nanomedicine2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Joint Meeting of the Austrian and German Pharmaceutical Sciences
    • Place of Presentation
      Innsbruck, Austria, University of Innsbruck
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] Controlled Intracellular trafficking of Non-viral Vectors2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 14th Annual Meeting of ASGCT Scientific Symposium Gene & Cell Therapy Around the Globe : A Showcase of Asia
    • Place of Presentation
      Washington State Convention & Trade Center (USA)(招待講演)
    • Year and Date
      2011-05-21
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 3rd Asian Biomaterials Congress
    • Place of Presentation
      BEXCO Busan (Korea)(招待講演)
    • Year and Date
      2011-09-19
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] DDS製剤の臨床応用への課題、DDS製剤の臨床応用を目指して2011

    • Author(s)
      原島秀吉
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京)(招待講演)
    • Year and Date
      2011-05-31
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] バイオイメージングで可視化するナノメディシンの世界~多機能性エンベロープ型ナノ構造体が拓く遺伝子治療への道~2011

    • Author(s)
      原島秀吉
    • Organizer
      第20回日本バイオイメージング学会学術集会
    • Place of Presentation
      千歳科学技術大学(北海道)(招待講演)
    • Year and Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011

    • Author(s)
      原島秀吉
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)(招待講演)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011

    • Author(s)
      Harashima H
    • Organizer
      Joint Meeting of the Austrian and German PharmaceuticalSciences
    • Place of Presentation
      University of Innsbruck (Austria)(招待講演)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] KALA-modified multi-layered nano particles as antigen gene carrier for MHC Class-I mediated antigen presentation in DNA vaccine approach2011

    • Author(s)
      Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yanashita A, Katoono R, Yui N, Harashima H
    • Organizer
      38th Annual Meeting & Exposition of the Controlled Release Society (CRS)
    • Place of Presentation
      Gaylord National Hotel and Convention Center (U.S.A.)
    • Year and Date
      2011-08-02
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011

    • Author(s)
      原島秀吉
    • Organizer
      第40回日本免疫学会学術集会関連分野セミナー
    • Place of Presentation
      幕張メッセ(千葉)(招待講演)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Joint Meeting of the Austrian and German Pharmaceutical Sciences
    • Place of Presentation
      University of Innsbruck (Austria)(招待講演)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Concept and Application of MEND2010

    • Author(s)
      Hideyoshi Harashima, Nanotechnology for In Vivo Gene Delivery
    • Organizer
      2010 FIP PSWC/AAPS Annual Meeting and Exposition, Short Course: Nanotechnology from A to Z: Achievement in Drug Delivery and Tissue Engineering
    • Place of Presentation
      New Orleans, U. S. A. Ernest N. Morial Convention Center
    • Year and Date
      2010-11-14
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] MENDで拓く創薬への道2010

    • Author(s)
      原島秀吉
    • Organizer
      金沢大学薬学シンポジウム2010創薬動態フォーラムin金沢
    • Place of Presentation
      金沢大学角間キャンパス金沢 招待講演
    • Year and Date
      2010-05-28
    • Data Source
      KAKENHI-PROJECT-22659006
  • [Presentation] 多機能性エンベロープ型ナノ構造体による次世代医薬への新たな展開2010

    • Author(s)
      原島秀吉
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島 招待講演
    • Year and Date
      2010-05-12
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Multifunctional envelope-type nano device for non-viral gene delivery: Concept and application for nanomedicine2009

    • Author(s)
      H. Harashima
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Hakata, Japan(invited)
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application for nanomedicine2009

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      Asian Federation for Pharmaceutical Sciences 2009
    • Place of Presentation
      Centennial Hall Kyushu University, Fukuoka, Japan
    • Year and Date
      2009-10-17
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application of programmed packaging2009

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 8^<th> Cerebral Vascular Biology 2009
    • Place of Presentation
      Sendai Excel Hotel Tokyu, Sendai, Japan
    • Year and Date
      2009-07-01
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Multifunctional envelope-type Nano Device for in vivo systemic delivery of siRNA2008

    • Author(s)
      H. Harashima
    • Organizer
      68th International Congres of FIP
    • Place of Presentation
      Basel, Switzerland(invited)
    • Year and Date
      2008-09-02
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Controlled Intracellular Trafficking of Non-viral Vector.2008

    • Author(s)
      H.Harashima
    • Organizer
      The 10th Annual Meeting of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy.
    • Place of Presentation
      Seatle.Washington.USA
    • Year and Date
      2008-05-30
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      第23回日本DDS学会永井賞受賞講演
    • Place of Presentation
      熊本(invited)
    • Year and Date
      2007-06-15
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      日本薬学会第127年会(学術振興賞受賞講演)
    • Place of Presentation
      富山(invited)
    • Year and Date
      2007-03-29
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Controlled Intracellular Trafficking of Non-viral Vector2007

    • Author(s)
      H. Harashima
    • Organizer
      The 10th Annual Meeing of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy
    • Place of Presentation
      Seatle, Washington, USA
    • Year and Date
      2007-05-30
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007

    • Author(s)
      H. Harashima
    • Organizer
      13th International Symposium on Recent Advances in Drug Delivery Systems
    • Place of Presentation
      Salt Lake City, Utah, USA.(invited)
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] Cellular uptake mechanism and intracellular trafficking study of the novel C152-peptide-modified liposomes(C152-Lip)2007

    • Author(s)
      ディッキームダキュル、秋田英万、タンエルダル、原島秀吉
    • Organizer
      第23回日本DDS学会
    • Place of Presentation
      熊本(熊本日航ホテル)
    • Year and Date
      2007-06-15
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      第23会日本DDS学会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-15
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007

    • Author(s)
      原島秀吉
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-29
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007

    • Author(s)
      H.Harashima
    • Organizer
      13th International Symposium on Recent Advances in Drug Delivery Systems
    • Place of Presentation
      Salt Lake City.Utah.USA.
    • Data Source
      KAKENHI-PROJECT-20015003
  • [Presentation] 血液サンプルを用いた2型糖尿病の遺伝子診断システムの開発2007

    • Author(s)
      林泰弘、飯田慎也、中谷明弘、澤田章弘、加地範匡、紙谷浩之、馬場嘉信、原島秀吉
    • Organizer
      日本薬剤学会第22年会
    • Place of Presentation
      大宮(大宮ソニックシティ)
    • Year and Date
      2007-05-21
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] 血管内皮細胞標的化ペプチド搭載リポソームの細胞内取り込み機構の解析2007

    • Author(s)
      秋田英万、ディッキー・ムダキュル、タン・エルダル、原島秀吉
    • Organizer
      日本薬剤学会第22年会
    • Place of Presentation
      大宮(大宮ソニックシティ)
    • Year and Date
      2007-05-21
    • Data Source
      KAKENHI-PROJECT-18200032
  • [Presentation] A Multi-functional envelope type nano device as an anti-tumor gene delivery system2007

    • Author(s)
      原島 秀吉
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18015004
  • [Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      IBS 2012 15th International Biotechnology Symposium and Exhibition
    • Place of Presentation
      EXCO Daegu, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam RAI, Amsterdam, The Netherland
    • Invited
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Multifunctional Envelope-type Nano Device as gene delivery system for Nanomedicine

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      The 10th France - Japan DDS Symposium
    • Place of Presentation
      Grande Hotel de Bordeaux, Bordeaux, France
    • Invited
    • Data Source
      KAKENHI-PROJECT-22229001
  • [Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines

    • Author(s)
      Hideyoshi Harashima
    • Organizer
      FIP Centennial, 2012
    • Place of Presentation
      Amsterdam RAI (The Netherlands)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22659006
  • 1.  KAMIYA Hiroyuki (10204629)
    # of Collaborated Projects : 10results
    # of Collaborated Products : 10results
  • 2.  AKITA Hidetaka (80344472)
    # of Collaborated Projects : 8results
    # of Collaborated Products : 32results
  • 3.  SHINOHARA Yasuo (60226157)
    # of Collaborated Projects : 7results
    # of Collaborated Products : 0results
  • 4.  YAMADA Yuma (60451431)
    # of Collaborated Projects : 5results
    # of Collaborated Products : 14results
  • 5.  BABA Yoshinobu (30183916)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 5results
  • 6.  大熊 芳明 (70192515)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 0results
  • 7.  小暮 健太朗 (70262540)
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    # of Collaborated Products : 7results
  • 8.  KAZUO Maruyama (30130040)
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    # of Collaborated Products : 0results
  • 12.  KOYABU Noriko (00315102)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 13.  YASUYUKI Igarashi (70091965)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 14.  SABURO Sone (40145024)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 15.  MATSUDA Akira (90157313)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 16.  HYOUDOU Mamoru (30548186)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 8results
  • 17.  SUGITA Masahiko (80333532)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 4results
  • 18.  NAKAMURA Takashi (20604458)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 7results
  • 19.  SUGIYAMA Yuichi (80090471)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 20.  SUZUKI Yousuke
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 21.  MINAKAWA Noriaki (40209820)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 22.  SASAKI Shigeki (10170672)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 2results
  • 23.  NAGATSUGI Fumi (90208025)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 24.  SHINDO Mitsuru (40226345)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results
  • 25.  NOMURA Masatoshi (30315080)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results
  • 26.  MATSUNAGA Isamu (00254425)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 2results
  • 27.  KAJIMOTO Kazuaki (10416216)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 28.  HAYASHI Yasuhiro (30548178)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results
  • 29.  IGARASHI Tatuhiko (90467431)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 30.  TERASAKI Tetsuya (60155463)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 31.  OHTANI Hisakazu (70262029)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 32.  MIZUGUCHI Hiroyuki (50311387)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 33.  HANANO Manabu (60012598)
    # of Collaborated Projects : 1results
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  • 34.  IGA Tatsuji (60012663)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 35.  FUKUDA Hideomi (50080172)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 36.  桑島 正道 (00205262)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 37.  松村 保広 (90209619)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 38.  中谷 明弘 (60301149)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 3results
  • 39.  畠山 浩人 (70504786)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 7results
  • 40.  渡慶次 学 (60311437)
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    # of Collaborated Products : 2results
  • 41.  松尾 保孝 (90374652)
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    # of Collaborated Products : 0results
  • 42.  松尾 浩民 (60274479)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 43.  KIKUCHI Hiroshi
    # of Collaborated Projects : 1results
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  • 44.  菊地 寛
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    # of Collaborated Products : 0results
  • 45.  TAKAYANAGI RYOICHI
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    # of Collaborated Products : 1results
  • 46.  Teramoto Noriyoshi
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    # of Collaborated Products : 1results
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    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
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    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 49.  ISODA Seiji
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 50.  TAKANO Mikio
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    # of Collaborated Products : 1results
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    # of Collaborated Products : 5results
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    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
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    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
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    # of Collaborated Products : 1results
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    # of Collaborated Projects : 0results
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