Harashima Hideyoshi 原島秀吉

… Alternative Names

原島秀吉ハラシマヒデヨシ

HARASHIMA Hideyoshi 原島秀吉

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Researcher Number	00183567
Other IDs
Affiliation (Current)	2022: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 北海道大学, 薬学研究院, 教授 2009 – 2014: 北海道大学, 薬学研究科(研究院), 教授 2013: 北海道大学, 薬学研究院, 教授 2006 – 2012: 北海道大学, 大学院・薬学研究院, 教授 2011: 北海道大学, 薬学研究科・研究院, 教授 … More 2009 – 2011: 北海道大学, 薬学研究院, 教授 2010: 北海道大学 2010: 北海道大学, 大学院・農学研究院, 教授 2006: 北海道大学, 大学院薬学研究院, 教授 1999 – 2005: 北海道大学, 大学院・薬学研究科, 教授 2000: Hokkaido Univ., Faculty of Pharmaceutical Sciences, Prof., 薬学研究科, 教授 1997 – 1998: 徳島大学, 薬学部, 助教授 1990 – 1995: 徳島大学, 薬学部, 助教授 1987: 東京大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / 応用薬理学・医療系薬学 / Biomedical engineering/Biological material science / Science and Engineering / Physical pharmacy / Medical pharmacy / Physical pharmacy / Drug development chemistry / Biological pharmacy / Medium-sized Section 90:Biomedical engineering and related fields … More Except Principal Investigator … More Drug development chemistry / Infectious disease medicine / Physical pharmacy / 応用薬理学・医療系薬学 / Basic Section 90120:Biomaterials-related / Medium-sized Section 90:Biomedical engineering and related fields Less
Keywords	Principal Investigator GALA / トランスフェリン / エンドサイトーシス / 細胞内動態制御 / MEND / 薬物送達システム / siRNA / 細胞内動態 / リポソーム / エンドソーム … More / オクタアルギニン / がん / 遺伝子治療 / 遺伝子ベクター / 2型糖尿病 / 遺伝子診断 / 網羅的解析 / 遺伝子デリバリー / ミトコンドリア / 非ウイルスベクター / endocytosis / 核移行シグナル / ターゲティング / 分子シンクロナイゼーション / 耐性 / レセプター / ソーティング / 核局在化シグナル / パッケージング / OLETFラット / 多重型 / 多機能性エンベロープ型ナノ構造体 / ハイドロダイナミクス法 / ワクチン / 抗腫瘍効果 / アジュバント / 核内動態制御 / KALA / 人工遺伝子デリバリーシステム / ウイルスベクター / Drug delivery system / Liposomes / intracellular trafficking / アデノウイルス / 定量的評価 / リソリーム / PCR / 転写阻害 / エンドサイドシス / リポリーム / DDS / 動写阻害 / シンクロナイゼーション / ポリエチレンイミン / 核膜融合モデル / 核膜 / 遺伝子デソバソー / ステアリルオクタアルギニン / 原子間顕微鏡 / 遺伝子カテゴリー / Othuka Long-Evans Tokushima Fatty (OLETF)ラット / カルパイン10 / 遺伝子発現 / 人工遺伝子デリバリー / in vivo / 癌 / MTS / オルガネラターゲティング / 細胞内ターゲティング / 遺伝子導入 / MMP / がん治療 / PPD-MEND / トランスサイトーシス / 血管透過 / 遺伝子デリバリーシステム / IRO / カベオラ / R8-NEND / デリバリーシステム / PPD / エンドソーム脱出 / トポロジー / ナノ構造体 / 細胞性免疫 / 細胞透過性ペプチド / MHCクラス-I / 抗原提示 / ナノマシン / マイクロ流路 / ナノパッケージング / pH-感受性カチオニック脂質 / 還元環境応答性 / ミトコンドリア送達 / 自己活性化システム / バイセル / 核送達 / 機能性核酸 / スイッチ機能 / DNAワクチン / 樹状細胞 / スイッチ / スイツチ / 細胞内シグナル / 薬物速度論 / オプソニン / 補体レセプター / 飽和性 / 粒子径 / Pharmacokinetics / Opsonin / Complement receptor / Saturation / Diameter / 遺伝子 / エネルギー代謝 / 抗がん剤 / アンチセンス / Tumor / Gene / トランスフェリン修飾リポソーム / リサイクル / transferrin liposomes / recycling / 転写効率 / 共焦点レーザー顕微鏡 / ライソゾーム / 体内動態制御 / adeno-virus / transcriptional efficiency / quantification / ソーティング素子 / gene delivery system / octaarginin / programmed packaging / 核酸ナノ医療 / ナノDDS / がん免疫療法 / ミトコンドリア遺伝子治療 / 細胞内局在 / 脂質ナノ粒子 / 核酸送達 / ナノＤＤＳ … More Except Principal Investigator 薬物送達システム / リポソーム / 核酸医薬 / 脂質 / 結核 / Glial-Derived Neurotrophic Factor / ヌクレアーゼ抵抗性 / 4'-チオ核酸 / siRNA / ベクター / ヌクレアーゼ抵抗性核酸 / 2'-O-メチル-4'-チオリポヌクレオシド / SNALP / MEND / miRNA / コレステロール / Apo-B / 2'-O-メチル-4'-チオリボヌクレオシド / 4'-チオDNA / ホタルルシフェラーゼ / Dicer / ゲノム創薬 / RNA干渉 / ヌクレアーゼ祇抗性核酸 / NMR / si RNA / antisense RNA / 2'-0-メチル-4'-チオリボヌクレオシド / アプタマー / RNAi / 膜透過性ペプチド / マクロピノサイトーシス / 2'-0-メチル-4'-チオリポヌクレオシド / マクロビノサイトーシス / 薬物送達 / ナノメディスン / 2型糖尿病 / 疾患モデルマウス / ２型糖尿病 / ミトコンドリア / 機能性人工核酸 / 細菌 / 感染症 / 免疫学 / 糖脂質 / ワクチン / マクロファージ / ライソゾーム / オプソニン / 補体レセプター / 薬物速度論 / リポソ-ム / 細胞内運命 / DDS / クリアランス / 補体 / Drug delivery system / Liposome / Macrophage / Lysosome / Opsonin / Complement receptor / Pharmacokinetics / 遺伝子治療 / 膜融合リポソーム / パーキンソン病 / 脳毛細血管内皮細胞 / 血液脳関門 / in vitro / in vivo / 遺伝子の発現 / Gene Therapy / HVJ-liposomes / Parkinson' disease / Brain capillary endothelial cells / Blood-brain barrier / 強心配糖体 / ウアバイン / 心筋収縮力 / Na^+,K^+ATPase / 心臓灌流実験 / 脳 / グルコース代謝 / ベンゾジアゼピンレセプター / Na^+ / K^+ATPase / ベンゾジアゼピン / Na^+,Ka^+ATPase / Cardiac glycosides / Ouabain / Positive inotropic action / Na^+,K^+ ATPase / Isolated perfused heart / Brain / Glucose metabolism / ドラッグデリバリーシステム / 脂質ナノ粒子 / 高分子ナノ粒子 / 精密重合 Less

Strategic creation of polymer-lipid hybrid nanoparticles for tissue-selective nucleic acid delivery
- Principal Investigator
  
  磯野拓也
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Development of gene delivery systems for liver diseases treatment and cancer treatmentHost Researcher
- Host Researcher
  
  原島秀吉
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Hokkaido University
Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking stepsPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
ＢＣＧ搭載ナノ粒子の細胞内動態制御に基づいた革新的膀胱癌治療システムの創製Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
MENDで拓く遺伝子治療への道：遺伝子の運び屋からナノマシンへPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Programmed Activationに基づく人工DNAワクチンの創製Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
Novel gene delivery system with switch functionPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides
- Principal Investigator
  
  SASAKI Shigeki
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyushu University
Developent of glycolipid vaccines against tuberculos is
- Principal Investigator
  
  SUGITA Masahiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kyoto University
Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapyPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチンPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Development of multifunctional envelope-type nano device encapsulating highly nuclease resistant oligonucleotides
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and ratsPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
ミトコンドリアを標的とする多重型・多機能性エンベロープ型ナノ構造体の開発Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
2型糖尿病の遺伝子診断用候補遺伝子の網羅的解析及びその機能解析Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
臨床試験導入を目指した肝がん用in vivo高発現型人工遺伝子ベクターの開発Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Development of Multifunctional Envelope type Nano Device based on Programmed PackagingPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  HOKKAIDO UNIVERSITY
ゲノム機能情報に基づいた糖尿病薬の処方設計支援システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hokkaido University
選択的抗癌システムを目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング系の構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Optimization of pharmacokinetics and intracellular pharmacokinetics of viral and non-viral gene delivery systemPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
遺伝子ベクター開発のための細胞内ソーティング素子のスクリーニング素の構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
核ターゲティングの新戦略:核膜の特殊性に基づいた標的化Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Intracellular control of transferrin-modified liposomes with Cholesteryl GALA for optimum drug delivery systemPrincipal Investigator
- Principal Investigator
  
  HIDEYOSHI Harashima
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
選択的抗腫瘍システムの開発を目指した細胞内動態の分子シンクロナイゼーションPrincipal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.
- Principal Investigator
  
  KOYABU Noriko, 松尾浩民
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
トリプルターゲティングによるがん細胞に特異的な核内転写抑制システムの構築Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokushima
核内転写制御による抗腫瘍効果を最適化するための細胞内動態制御システムの開発Principal Investigator
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hokkaido University
  The University of Tokushima
Optimization of drug delivery system for antitumor agents based on the energy metabolism inhibition of tumor cellsPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokushima, Faculty of Pharmaceutical Sciences
Uptake mechanism and intracellular destiny of liposomes in RESPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokushima, Faculty of Pharmaceutical Sciences
Development of intracellular drug delivery system utilizing liposomes
- Principal Investigator
  
  KIWADA Hiroshi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokushima
Kinetical analysis of pharmacodynamics based on drug-receptor interactions
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo

[Book] THE創薬　小資源国家にっぽんの生きる道　日本薬学会編2021
- Author(s)
  原島秀吉（共著）
- Total Pages
  381
- Publisher
  薬事日報社
- ISBN
  9784840815536
- Data Source
  KAKENHI-PROJECT-19H01170
[Book] 核酸科学ハンドブック2020
- Author(s)
  原島秀吉（共著）
- Total Pages
  565
- Publisher
  講談社
- ISBN
  9784065207864
- Data Source
  KAKENHI-PROJECT-19H01170
[Book] ドラッグキャリア設計入門　DDSからナノマシンまで2019
- Author(s)
  原島秀吉、片岡一則
- Total Pages
  217
- Publisher
  丸善出版株式会社
- ISBN
  9784621303658
- Data Source
  KAKENHI-PROJECT-19H01170
[Book] Application of a fusiogenic peptide GALA for intracellular delivery2011
- Author(s)
  Nakase I, Kogure K, Harashima H, Futaki S
- Total Pages
  10
- Publisher
  Methods Mol Biol
- Data Source
  KAKENHI-PROJECT-22229001
[Book] Delivery of Nucleic Acids and Gene Delivery2011
- Author(s)
  H.Akita, H.Hatakeyama, I.A.Khalil, Y.Yamada, H.Harashima
- Total Pages
  34
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22229001
[Book] ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用-遺伝子医学MOOK別冊2011
- Author(s)
  山田勇磨、中村孝司、原島秀吉
- Total Pages
  8
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22229001
[Book] バイオテクノロジーシリーズ蛍光イメージング/MRIプローブの開発2011
- Author(s)
  秋田英万、山田勇磨,中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
- Total Pages
  10
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-22229001
[Book] Adv Biochem Eng Biotechnol(A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device.)2009
- Author(s)
  H.Hatakeyama, H.Akita, K.Kogure, H.Harashima
- Data Source
  KAKENHI-PROJECT-20015003
[Book] Contrib Nephrol (Nonviral gene delivery)2008
- Author(s)
  Akita H, Harashima H.
- Total Pages
  19
- Publisher
  KARGER
- Data Source
  KAKENHI-PROJECT-18200032
[Book] 分子薬物動態学(第17章高分子・遺伝子の体内動態の制御(細胞内動態を中心に))2008
- Author(s)
  秋田英万、原島秀吉
- Total Pages
  19
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-18200032
[Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy: Gene Design and Delivery Edit. by Kazunari Taira, Kazunori Kataoka,2005
- Author(s)
  H.Akita, I.A Khalil, K.Kogure, H.Harashima.
- Total Pages
  19
- Publisher
  Springer-Verlag Tokyo, Inc.
- Data Source
  KAKENHI-PROJECT-17659039
[Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller(Eds. Modern Biopharmaceuticals.)2005
- Author(s)
  K.Kogure, H.Akita, H.Kamiya, H.Harashima.
- Total Pages
  15
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-17016005
[Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy : Gene Design and Delivery(Edit. by Kazunari Taira, Kazunori Kataoka,)2005
- Author(s)
  H.Akita, I.A Khalil, K.Kogure, H.Harashima.
- Total Pages
  19
- Publisher
  Springer-Verlag Tokyo, Inc.
- Data Source
  KAKENHI-PROJECT-17016005
[Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller Eds. Modern Biopharmaceuticals.2005
- Author(s)
  K.Kogure, H.Akita, H.Kamiya, H.Harashima.
- Total Pages
  15
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen.2021
- Author(s)
  Kimura Seigo、Khalil Ikramy A.、Elewa Yaser H.A.、Harashima Hideyoshi
- Journal Title
  
  J Control Release.
  
  Volume: 330 Pages: 753-764
- DOI
  10.1016/j.jconrel.2021.01.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07420, KAKENHI-PROJECT-19H01170
[Journal Article] GALA-Modified Lipid Nanoparticles for the Targeted Delivery of Plasmid DNA to the Lungs.2021
- Author(s)
  Hagino Y, Khalil IA, Kimura S, Kusumoto K, Harashima H
- Journal Title
  
  Mol Pharm.
  
  Volume: 18 Pages: 878-888
- DOI
  10.1021/acs.molpharmaceut.0c00854
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Development of a Nanoparticle That Releases Nucleic Acids in Response to a Mitochondrial Environment2020
- Author(s)
  Yamada Y, Fukuda Y, Sasaki D, Maruyama M, Harashima H
- Journal Title
  
  Mitochondrion
  
  Volume: 52 Pages: 67-74
- DOI
  10.1016/j.mito.2020.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19H01170
[Journal Article] Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles2020
- Author(s)
  Sato Y, Okabe N, Note Y, Hashiba K, Maeki M, Tokeshi M, Harashima H
- Journal Title
  
  Acta Biomaterialia
  
  Volume: 102 Pages: 341-350
- DOI
  10.1016/j.actbio.2019.11.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity2020
- Author(s)
  Nakamura T, Yamada K, Sato Y, Harashima H.
- Journal Title
  
  Int J Pharm.
  
  Volume: 587 Pages: 119652-119652
- DOI
  10.1016/j.ijpharm.2020.119652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution.2020
- Author(s)
  Nakamura Takashi, Kawai Minori, Sato Yusuke, Maeki Masatoshi, Tokeshi Manabu, Harashima Hideyoshi
- Journal Title
  
  Mol Pharm.
  
  Volume: 17 Pages: 944-953
- DOI
  10.1021/acs.molpharmaceut.9b01182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-18K19889, KAKENHI-PROJECT-19H01170
[Journal Article] Different Kinetics for the Hepatic Uptake of Lipid Nanoparticles Between the Apolipoprotein E/low Density Lipoprotein Receptor and the N-acetyl-d-galactosamine/asialoglycoprotein Receptor Pathway.2020
- Author(s)
  Hashiba A, Toyooka M, Sato Y, Maeki M, Tokeshi M, Harashima H.
- Journal Title
  
  J Control Release
  
  Volume: 327 Pages: 217-226
- DOI
  10.1016/j.jconrel.2020.08.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Validation of a mitochondrial RNA therapeutic strategy using fibroblasts from a Leigh syndrome patient with a mutation in the mitochondrial ND3 gene.2020
- Author(s)
  Yamada Y, Somiya K, Miyauchi A, Osaka H, Harashima H
- Journal Title
  
  Scientific Reports
  
  Volume: - Pages: 7511-7511
- DOI
  10.1038/s41598-020-64322-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03648
[Journal Article] A study of the endocytosis mechanism and transendothelial activity of lung-targeted GALA-modified liposomes.2019
- Author(s)
  Santiwarangkool S, Akita H, Khalil IA, Abd Elwakil MM, Sato Y, Kusumoto K, Harashima H.
- Journal Title
  
  J Control Release.
  
  Volume: 307 Pages: 55-63
- DOI
  10.1016/j.jconrel.2019.06.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] A Multifunctional Lipid-Based Nanodevice for the Highly Specific Codelivery of Sorafenib and Midkine siRNA to Hepatic Cancer Cells.2019
- Author(s)
  Younis MA, Khalil IA, Abd Elwakil MM, Harashima H
- Journal Title
  
  Mol Pharm.
  
  Volume: 16 Pages: 4031-4044
- DOI
  10.1021/acs.molpharmaceut.9b00738
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Spleen selective enhancement of transfection activities of plasmid DNA driven by octaarginine and an ionizable lipid and its implications for cancer immunization.2019
- Author(s)
  Kimura S, Khalil IA, Elewa YHA, Harashima H
- Journal Title
  
  J Control Release.
  
  Volume: 313 Pages: 70-79
- DOI
  10.1016/j.jconrel.2019.09.009
- NAID
  120006896748
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] Targeted mitochondrial delivery of antisense RNA-containing nanoparticles by a MITO-Porter for safe and efficient mitochondrial gene silencing.2019
- Author(s)
  396.Kawamura E, Hibino M, Harashima H, Yamada Y.
- Journal Title
  
  Mitochondrion
  
  Volume: 28 Pages: 178-188
- DOI
  10.1016/j.mito.2019.08.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094
[Journal Article] Recent advances in the targeting of systemically administered non-viral gene delivery systems2019
- Author(s)
  Khalil IA, Sato Y, Harashima H.
- Journal Title
  
  Expert Opinion on Drug Delivery
  
  Volume: 16 Pages: 1037-1050
- DOI
  10.1080/17425247.2019.1656196
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution.2019
- Author(s)
  Nakamura Takashi, Yamada Yuma, Sato Yusuke, Khalil A Ikramy, Harashima Hideyoshi
- Journal Title
  
  Biomaterials.
  
  Volume: 218 Pages: 119329-119329
- DOI
  10.1016/j.biomaterials.2019.119329
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19888, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] A nanocarrier system for the delivery of nucleic acids targeted to pancreatic beta cell line.2014
- Author(s)
  Yamada Y., Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S., Harashima H.
- Journal Title
  
  Biomaterials
  
  Volume: 35 Pages: 6430-6438
- DOI
  10.1016/j.biomaterials.2014.04.017
- NAID
  120005512023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-26461383
[Journal Article] Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes2014
- Author(s)
  Nomura M, Hei-lay Z, Wang L, Morinaga H, Takayanagi R, Teramoto N
- Journal Title
  
  Mol. Ther. Nucleic Acids
  
  Volume: 57 Pages: 157-166
- DOI
  10.1007/s00125-013-3062-2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12F02426, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23390247, KAKENHI-PROJECT-23591356, KAKENHI-PROJECT-26282148, KAKENHI-PROJECT-26461383
[Journal Article] Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, mincle2014
- Author(s)
  Hattori Y, Morita, D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(22) Pages: 15405-12
- DOI
  10.1074/jbc.m114.566489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-14J03573, KAKENHI-PROJECT-24390255, KAKENHI-PROJECT-25460543, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213, KAKENHI-PROJECT-26860323
[Journal Article] Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo2014
- Author(s)
  Yasuhiro Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato, Afsana Akhter, Yu Sakurai, Hiroto Hatakeyama, Mamoru Hyodo, Noritada Kaji, Yoshinobu Baba, Hideyoshi Harashima
- Journal Title
  
  Molecular Therapy ― Nucleic Acids
  
  Volume: 3
- DOI
  10.1038/mtna.2014.4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
[Journal Article] RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGDmodified liposomal-siRNA system2014
- Author(s)
  Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Noritaka Ohga, Kyoko Hida, Hideyoshi Harashima
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 173 Pages: 110-118
- DOI
  10.1016/j.jconrel.2013.10.003
- NAID
  120005476193
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-11J05557, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-25462909, KAKENHI-PROJECT-25893001, KAKENHI-PROJECT-26830101
[Journal Article] Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide.2013
- Author(s)
  Eriko Kawamura, Yuma Yamada, Yukari Yasuzaki, Mamoru Hyodo and Hideyoshi Harashima.
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 116(5) Issue: 5 Pages: 634-637
- DOI
  10.1016/j.jbiosc.2013.05.001
- NAID
  110009685218
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] Investigation of siRNA nanoparticle formation using mono-cationic detergents and its use in gene silencing in human HeLa cells.2013
- Author(s)
  Yamada Y, Suzuki R, Harashima H.
- Journal Title
  
  Cancers.
  
  Volume: 5 Pages: 1413-1425
- DOI
  10.3390/cancers5041413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication2013
- Author(s)
  Hossen MN, Kajimoto K, Akita H, Hyodo M, Harashima H.
- Journal Title
  
  J. Control. Release
  
  Volume: 171 Pages: 104-12
- DOI
  10.1016/j.jconrel.2013.07.013
- NAID
  120005365904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002
[Journal Article] The transfection activity of R8-modifiednanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine.2013
- Author(s)
  Toriyabe N, Hayashi Y, Harashima H.
- Journal Title
  
  Biomaterials
  
  Volume: 34 Pages: 1337-43
- DOI
  10.1016/j.biomaterials.2012.10.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23790038
[Journal Article] The transfection activity of R8-modified nanoparticles and siRNA condensation using pH sensitive stearylated-octahistidine2013
- Author(s)
  Toriyabe N, Hayashi Y, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume: 34(4) Pages: 1337-1343
- DOI
  10.1016/j.biomaterials.2012.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells2013
- Author(s)
  Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
- Journal Title
  
  J Pharm Sci. (Wiley)
  
  Volume: 102 Pages: 1008-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002
[Journal Article] Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier2013
- Author(s)
  Yamada Y, Harashima H.
- Journal Title
  
  Mitochondrion
  
  Volume: 13 Pages: 526-32
- DOI
  10.1016/j.mito.2012.09.001
- NAID
  120005394544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053
[Journal Article] A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence.2013
- Author(s)
  Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, Harashima H.
- Journal Title
  
  Int J Pharm.
  
  Volume: 456 Pages: 195-201
- DOI
  10.1016/j.ijpharm.2013.07.068
- NAID
  120005394547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-25462909
[Journal Article] Th1-skewed tissue responses to a mycolyl glycolipid in mycobacteria-infected rhesus macaques.2013
- Author(s)
  Morita D, Miyamoto A, Hattori Y, Komori T, Nakamura T, lgarashi T, Harashima H, Sugita M
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 441(1) Pages: 108-113
- DOI
  10.1016/j.bbrc.2013.10.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04754, KAKENHI-PROJECT-24390255
[Journal Article] Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system2013
- Author(s)
  Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H, Harashima H
- Journal Title
  
  Mol. Ther.
  
  Volume: (印刷中) Pages: 1195-1203
- DOI
  10.1038/mt.2013.57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02352, KAKENHI-PROJECT-21229002, KAKENHI-PUBLICLY-24107502
[Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells2013
- Author(s)
  Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
- Journal Title
  
  J. Pharm Sci.
  
  Volume: 102 Pages: 1008-1015
- DOI
  10.1002/jps.23442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-24659007, KAKENHI-PUBLICLY-24106731
[Journal Article] Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter2013
- Author(s)
  Kawamura E, Yamada Y, Harashima H.
- Journal Title
  
  Mitochondrion
  
  Volume: 13 Pages: 610-4
- NAID
  120005460249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002
[Journal Article] Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide2013
- Author(s)
  Akita H, Enoto K, Tanaka H, Harashima H
- Journal Title
  
  Molecular Therapy
  
  Volume: 21(2) Pages: 309-317
- DOI
  10.1038/mt.2012.235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Development of a novel drug delivery system consisting of an antitumor agent tocopheryl succinate2012
- Author(s)
  Hama S, Utsumi S, Fukuda Y, Nakayama K, Okamura Y, Tsuchiya H, Fukuzawa K, Harashima H, Kogure K
- Journal Title
  
  J Control Release.
  
  Volume: 161(3) Pages: 843-851
- DOI
  10.1016/j.jconrel.2012.05.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23390014
[Journal Article] Stearylated INF7 Peptide enhances endosomal escape and gene expression of PEGylated nanoparticles both in vitro and in vivo2012
- Author(s)
  El-Sayed A, Masuda T, Akita H, Harashima H
- Journal Title
  
  J Pharm Sci
  
  Volume: 101(2) Pages: 879-882
- DOI
  10.1002/jps.22807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
[Journal Article] Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes2012
- Author(s)
  Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, N.Yui
- Journal Title
  
  Biomaterials
  
  Volume: 33 Pages: 3952-3958
- DOI
  10.1016/j.biomaterials.2012.01.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053, KAKENHI-PLANNED-23107004
[Journal Article] Effect of the Anchor in Polyethylene Glycol-Lipids on the Transfection Activity of PEGylated Cationic Liposomes Encapsulating DNA2012
- Author(s)
  Kusumoto K, Akita H, El-Sayed A, Harashima H
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35(4) Issue: 4 Pages: 445-448
- DOI
  10.1248/bpb.35.445
- NAID
  130001872189
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
[Journal Article] The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition2012
- Author(s)
  Furukawa R, Yamada Y, Matsushima Y, Goto Y-I, Harashima H.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 2 Pages: 145-150
- DOI
  10.1016/j.fob.2012.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] Different Mechanisms for nanoparticle formation between pDNA and siRNA using polyrotaxane as the polycation2012
- Author(s)
  Y.Yamada, M.Hashida, T.Nomura, H.Harashima, Y Yamasaki, K.Kataoka, A.Yamashita, R.Katoono, N.Yui
- Journal Title
  
  Chemical physics and physical chemistry
  
  Volume: 13(5) Pages: 1161-1165
- DOI
  10.1002/cphc.201100800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PLANNED-23107004, KAKENHI-PROJECT-23680053
[Journal Article] Fabrication of functionalized double-lamellar multifunctional envelope-type nanodevices using a microfluidic chip with achaotic mixer array2012
- Author(s)
  Kitazoe K, Park YS, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
- Journal Title
  
  PLoS One
  
  Volume: 7(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter2012
- Author(s)
  Y.Yamada, H.Harashima
- Journal Title
  
  Biomaterials
  
  Volume: 33(5) Pages: 1589-1595
- DOI
  10.1016/j.biomaterials.2011.10.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system2012
- Author(s)
  G. Kanda, H. Ochiai, H. Harashima, and H. Kamiya
- Journal Title
  
  J.Biotechnol.
  
  Volume: 157(# 1) Pages: 41-101
- DOI
  10.1016/j.jbiotec.2011.09.016
- NAID
  120003811532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] A multifunctional envelope-type nano device for use in nanomedicine: concept and Applications.2012
- Author(s)
  Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H
- Journal Title
  
  Accounts of Chemical Research
  
  Volume: 45(7) Pages: 1113-1121
- DOI
  10.1021/ar200254s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PUBLICLY-24107502
[Journal Article] Noninvasive and efficient transdermal delivery of CpGoligodeoxynucleotide for cancer immunotherapy2011
- Author(s)
  Kigasawa K, Kajimoto K, Nakamura T, Hama S, Kanamura K, Harashima H, Kogure K
- Journal Title
  
  J Control Release
  
  Volume: 150(3) Pages: 256-265
- DOI
  10.1016/j.jconrel.2011.01.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Improving in Vivo Hepatic Transfection Activity by Controlling Intracellular Trafficking: The Function of GALA and Maltotriose2011
- Author(s)
  Akita H, Masuda T, Nishio T, Niikura K, Ijiro K, Harashima H
- Journal Title
  
  Mol.Pharmaceutics
  
  Volume: 8(4) Pages: 1436-1442
- DOI
  10.1021/mp200189s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22350076, KAKENHI-PROJECT-22655050, KAKENHI-PROJECT-22655059
[Journal Article] KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume: 32(26) Pages: 6342-6350
- DOI
  10.1016/j.biomaterials.2011.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22659006
[Journal Article] Dual imaging of mRNA and protein production : an investigation of the mechanism of heterogeneity in cationic lipid-mediated transgene expression2011
- Author(s)
  Akita H, Umetsu Y, Kurihara D, Harashima H
- Journal Title
  
  Int J Pharm
  
  Volume: 415(1-2) Pages: 218-220
- DOI
  10.1016/j.ijpharm.2011.05.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. Biochem2011
- Author(s)
  Hattori Y, Matsunaga I, Komori T, UrakawaT, Nakamura T, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
- Journal Title
  
  Biophys. Res. Commun
  
  Volume: 409(2) Pages: 304-307
- Data Source
  KAKENHI-PROJECT-21390304
[Journal Article] A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver2011
- Author(s)
  S. Fukunaga, G. Kanda, J. Tanase, H. Harashima, T. Ohyama, and H. Kamiya
- Journal Title
  
  Gene Ther
  
  Volume: (in press)
- DOI
  10.1038/gt.2011.127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system2011
- Author(s)
  H. Ochiai, H. Harashima, and H. Kamiya
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 112(# 5) Issue: 5 Pages: 432-434
- DOI
  10.1016/j.jbiosc.2011.07.001
- NAID
  110008761503
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] Functional improvement of an I.RQ-PEG-MEND for delivering genes to the lung2011
- Author(s)
  Ishitsuka T, Akita H, Harashima H
- Journal Title
  
  J Control Release
  
  Volume: 154(1) Pages: 77-83
- DOI
  10.1016/j.jconrel.2011.05.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity2011
- Author(s)
  Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286(19) Pages: 16800-16806
- Data Source
  KAKENHI-PROJECT-21390304
[Journal Article] Dual Function MITO-Porter, a Nano Carrier Integrating Both Efficient Cytoplasmic Delivery and Mitochondrial Macromolecule Delivery2011
- Author(s)
  Yamada Yuma, Ryo Furukawa, Yukari Yasuzaki, Harashima Hideyoshi
- Journal Title
  
  Mol.Ther.
  
  Volume: 19 Pages: 1449-1456
- DOI
  10.1038/mt.2011.99
- NAID
  120003898268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] Correction of Frameshift Mutations with Tailed Duplex DNAs2011
- Author(s)
  Y. Morita, H. Tsuchiya, H. Harashima, and H. Kamiya
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 34(# 9) Issue: 9 Pages: 1465-1468
- DOI
  10.1248/bpb.34.1465
- NAID
  130001872441
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300174, KAKENHI-PROJECT-22229001
[Journal Article] KALA-modified multi-layered nano- particles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume: 32(26) Pages: 6342-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Cell penetrating peptide-mediated systemic siRNA delivery to the liver.2011
- Author(s)
  Hayashi Y, Yamauchi J, Khalil IA, Kajimoto K, Akita H, Harashima H
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 419(1-2) Pages: 308-13
- DOI
  10.1016/j.ijpharm.2011.07.038
- NAID
  120003504743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23790038
[Journal Article] A touch-and-go lipid wrapping technique in microfluidic channels for rapid fabrication of multifunctional envelope-type gene delivery nanodevices2011
- Author(s)
  Kitazoe K, Wang J, Kaji N, Okamoto Y, Tokeshi M, Kogure K, Harashima H, Baba Y
- Journal Title
  
  Lab. Chip
  
  Volume: 11 Pages: 3256-3262
- DOI
  10.1039/c1lc20392d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23390014
[Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011
- Author(s)
  Hatakeyama H, Ito E, Yamamoto M, Akita H, Hayashi Y, Kajimoto K, Kaji N, Baba Y, Harashima H
- Journal Title
  
  Mol Ther
  
  Volume: 19(8) Pages: 1487-98
- NAID
  120003762627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines : Programmed endosomal escape and dissociation.2010
- Author(s)
  Akita H.; Kogure K.; Moriguchi R.; Nakamura Y.; Higashi T.; Nakamura T.; Serada S.; Fujimoto M.; Naka T.; Futaki S.; Harashima H.
- Journal Title
  
  J.Control.Release 143
  
  Pages: 311-317
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells.2010
- Author(s)
  Sato Y.; Hatakeyama H.; Harashima H.
- Journal Title
  
  Biol Pharm Bull. 33
  
  Pages: 1246-1249
- NAID
  130000300296
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake.2010
- Author(s)
  Takara K.; Hatakeyama H.; Ohga N.; Hida K.; Harashima H.
- Journal Title
  
  Int J Pharm. 396
  
  Pages: 143-148
- NAID
  120003118155
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009
- Author(s)
  Hatakeyama H.; Ito E.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
- Journal Title
  
  J Control Release. 139
  
  Pages: 127-132
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a steo-wise membrane fusion process.2009
- Author(s)
  H.Akita, A.Kudo, A.Minoura, M.Yamaguchi, IA.Khalil, R.Moriguchi, T.Masuda, R.Danev, K.Nagayama, K.Kogure, H.Harashima
- Journal Title
  
  Biomaterials 30
  
  Pages: 2940-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system.2009
- Author(s)
  Y.Sakurai, H.Hatakeyama, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 928-932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process2009
- Author(s)
  H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A. Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure and H. Harashima.
- Journal Title
  
  Biomaterials 30(15)
  
  Pages: 2940-9
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system.2009
- Author(s)
  Sakurai Y.; Hatakeyama H.; Akita H.; Oishi M.; Nagasaki Y.; Futaki S.; Harashima H.
- Journal Title
  
  Biol Pharm Bull. 32
  
  Pages: 928-932
- NAID
  130000117162
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.2009
- Author(s)
  H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure, H. Harashima
- Journal Title
  
  Biomaterials 30(15)
  
  Pages: 2940-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009
- Author(s)
  H.Hatakeyama, E.Ito, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
- Journal Title
  
  J.Control.Release 139
  
  Pages: 127-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape.2009
- Author(s)
  El-Sayed A, Masuda T, Khalil I, Akita H, Harashima H.
- Journal Title
  
  J Control Release. 138(2)
  
  Pages: 160-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription.2009
- Author(s)
  Masuda T, Akita H, Niikura K, Nishio T, Ukawa M, Enoto K, Danev R, Nagayama K, Ijiro K, Harashima H.
- Journal Title
  
  Biomaterials 30(27)
  
  Pages: 4806-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine- and octalysine- modified nanoparticles have different modes of endosomal escape.2008
- Author(s)
  A.El-Sayed, IA.Khalil, K.Kogure, S.Futaki, H.Harashima
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 23450-23461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives.2008
- Author(s)
  K. Sasaki, S. Chaki, Y. Nakamura, K. Kogure, H. Hamada, M. Ueno, S. Futaki, H. Harashima
- Journal Title
  
  Anal Bioanal Chem 391(8)
  
  Pages: 2717-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Efficient MHC Class I Presentation by Controlled Intracellular Trafficking of Antigens in Octaarginine-modified Liposomes.2008
- Author(s)
  T.Nakamura, R.Moriguchi, K.Kogure, N.Shastri, H.Harashima
- Journal Title
  
  Mol.Ther. 16
  
  Pages: 1507-1514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergisitic action of pH-sensitive fusogenic peptide derivatives.2008
- Author(s)
  K.Sasaki, S.Chaki, Y.Nakamura, K.Kogure, H.Hamada, M.Ueno, S.Futaki, H.Harashima
- Journal Title
  
  Anal.Bioanal.Chem. 391
  
  Pages: 2717-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008
- Author(s)
  El-Sayed A.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 23450-23461
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] An artificial virus-like nano carrier system: Enhanced endosomal escape of nano-particles via synergistic action of pH-sensitive fusogenic peptide derivatives. Anal.2008
- Author(s)
  Sasaki K.; Kogure K.; Chaki S.; Nakamura Y.; Hamada H.; Ueno M.; Futaki S.; Harashima H.
- Journal Title
  
  Bioanal.Chem. 391
  
  Pages: 2717-2727
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway.2008
- Author(s)
  D. Mudhakir, H. Akita, E. Tan, H. Harashima
- Journal Title
  
  J Control Release 125(2)
  
  Pages: 164-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine-and octalysine-modified nanoparticles have different modes of endosomal escape.2008
- Author(s)
  A. El-Sayed, IA. Khalil, K. Kogure, S. Futaki, H. Harashima
- Journal Title
  
  J Biol Chem 283(34)
  
  Pages: 23450-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] DNA microarray analysis on type 2 diabetes-related genes co-regulated between white blood cells and liver of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biol.2007
- Author(s)
  Y. Hayashi, S. Iida, Y. Sato, A. Nakaya, A. Sawada, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
- Journal Title
  
  Pharm. Bull 30(4)
  
  Pages: 763-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA2007
- Author(s)
  Nakamura, Y. ; Kogure, K. ; Futaki, S. ; Harashima, H.
- Journal Title
  
  J. Cont. Rel. 119
  
  Pages: 360-367
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Tumor targeting of doxorubicin by anti MT1-MMP antibodymodified PEG liposomes.2007
- Author(s)
  Hatakeyama H.; Akita H.; Ishida E.; Hashimoto K.; Kobayashi H.; Aoki T.; Yasuda J.; Obata K.; Kikuchi H.; Ishida T.; Kiwada H.; Harashima H.
- Journal Title
  
  Int.J.Pharm. 342
  
  Pages: 194-200
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Octaarginine-modified envelope-type nanoparticles for gene delivery. Gene Therapy nanoparticles for gene delivery2007
- Author(s)
  I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, K. Kataoka, and H. Harashima
- Journal Title
  
  Gene Therapy 14(8)
  
  Pages: 682-9
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007
- Author(s)
  Nakamura Y.; Kogure K.; Futaki S.; Harashima H.
- Journal Title
  
  J.Cont.Rel. 119
  
  Pages: 360-367
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Octaarginine-modified multifunctional envelope-type nano device for siRNA.2007
- Author(s)
  Y. Nakamura, K. Kogure, S. Futaki, H. Harashima
- Journal Title
  
  J. Cont. Rel. 119(3)
  
  Pages: 360-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature.2006
- Author(s)
  Iwasa A.; Akita H.; Khalil IA.; Kogure K.; Futaki S.; Harashima H.
- Journal Title
  
  BBA-Biomembranes 1758
  
  Pages: 713-720
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Evaluation of the nuclear delivery and intra-nuclear transcription of the plasmid DNA condensed with m (mu) and NLS- m by cytoplasmic and nuclear microinjection : comparative study with poly L-lysine.2006
- Author(s)
  H.Akita, M.Tanimoto, T.Masuda, K.Kogure, S.Futaki, H.Harashima.
- Journal Title
  
  J.Gen.Med. 8・2
  
  Pages: 198-206
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Non-linear pharmacodynamics in non-viral gene delivery system : Synergistic relationship between dose and nuclear transcription efficiency.2006
- Author(s)
  R.Moriguchi, K.Kogure, H.Harashima.
- Journal Title
  
  J.Cont.Re.l. 110・3
  
  Pages: 605-609
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006
- Author(s)
  I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
- Journal Title
  
  J.Biol.Chem. 281・6
  
  Pages: 3544-3551
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression.2006
- Author(s)
  I.A Khalil, K.Kogure, S.Futaki, H.Harashima.
- Journal Title
  
  J.Biol.Chem. 281・6
  
  Pages: 3544-5551
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.2006
- Author(s)
  Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
- Journal Title
  
  J.Pharm. Pharmacol. (in press)
- NAID
  120000954675
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Genome wide expression analysis of white blood cells and liver of pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats using a cDNA microarray.2006
- Author(s)
  S. Iida, Y. Sato, A. Nakaya, Y. Shinohara, Y. Hayashi, A. Sawada, H. Nagata, N. Kaji, H. Kamiya, Y. Baba, H. Harashima
- Journal Title
  
  Biol. Pharm. Bull 29(12)
  
  Pages: 2451-9
- NAID
  110006148670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] High density of octaarginine stimulates macropincytosis leading to an efficient intracellular trafficking for gene expression2006
- Author(s)
  1. I. A Khalil, K. Kogure, S. Futaki, and H. Harashima
- Journal Title
  
  J. Biol. Chem. 281(6)
  
  Pages: 3544-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.2006
- Author(s)
  Hatakeyama H.; Akita H.; Kogure K.; Oishi M.; Nagasaki Y.; Kihira Y.; Ueno M.; Kobayashi H.; Kikuchi H.; Harashima H.
- Journal Title
  
  Gene Therapy 14
  
  Pages: 68-77
- NAID
  110006402944
- Data Source
  KAKENHI-PROJECT-18109001
[Journal Article] Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy.2005
- Author(s)
  Y.Yamada, Y.Shinohara, T.Kakudo, S.Chaki, S.Futaki, H.Kamiya, H.Harashima
- Journal Title
  
  Int.J.Pharm. 303
  
  Pages: 1-7
- NAID
  120003702858
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Pharmacokinetics And Brain Uptake Of Lactoferrin In Rats.2005
- Author(s)
  B.Ji, J.Maeda, K.Inoue, H.Akita, H.Harashima, T.Suhara.
- Journal Title
  
  Life Sciences 78・8
  
  Pages: 851-855
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Kinetic analysys of protein production after DNA transfection.2005
- Author(s)
  Y.Yamada, H.Kamiya, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 299
  
  Pages: 34-40
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005
- Author(s)
  K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 296・1-2
  
  Pages: 142-150
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Biodistribution of octaarginine modified lisposomes in mice.2005
- Author(s)
  D.Mudhakir, H.Akita, I.A.Khalil, S.Futaki, H.Harashima.
- Journal Title
  
  Drug metabolism and Pharmacokinetics 20・4
  
  Pages: 275-281
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005
- Author(s)
  Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
- Journal Title
  
  Biol. Pharm. Bull. 28・10
  
  Pages: 1939-1942
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Construction of multifunctional envelope-type nano device by a SUV^*-fusion method.2005
- Author(s)
  K.Sasaki, K.Kogure, S.Chaki, Y.Kihira, M.Ueno, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 296・1-2
  
  Pages: 142-150
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005
- Author(s)
  R.Moriguchi, K.Kogure H.Akita, S.Futaki, M.Miyagishi, K.Taira, H.Harashima
- Journal Title
  
  Int.J.Pharm. 301
  
  Pages: 277-285
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids.2005
- Author(s)
  R.Moriguchi, K.Kogure H.Akila, S.Futaki, M.Miyagishi, K.Taira, H.Harashima.
- Journal Title
  
  Int.J.Pharm. 301
  
  Pages: 277-285
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005
- Author(s)
  Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
- Journal Title
  
  Biol.Pharm.Bull. 28・10
  
  Pages: 1939-1942
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article] Evaluation of nuclear translocation and transcription of plasmid DNA condensed with protamine by microinjection : introduction of Nuclear Translocation score.2005
- Author(s)
  T.Masuda, H.Akita, H.Harashima.
- Journal Title
  
  FEBS Lett. 579・10
  
  Pages: 2143-2148
- Data Source
  KAKENHI-PROJECT-17016005
[Journal Article]
- Author(s)
  H.Akita, K.Kogure, R.Moriguchi, Y.Nakamura, T.Higashi, T.Nakamura, S.Serada, M.Fujimoto, T.Naka, S.Futaki, H.Harashima
- Journal Title
  
  J.Control.Release (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Significant and prolonged antisense effect of multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide.
- Author(s)
  Y.Nakamura, K.Kogure, Y.Yamada, H.Harashima.
- Journal Title
  
  J.Pharm.Pharmacol. (in press)
- NAID
  120000954675
- Data Source
  KAKENHI-PROJECT-17016005
[Patent] 溶解剤2021
- Inventor(s)
  原島秀吉、佐藤悠介、アッバシ　サエド　アムジャド　ヨセフ、他
- Industrial Property Rights Holder
  国立大学法人北海道大学、常翔学園
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2020
- Inventor(s)
  佐藤悠介、原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 肝細胞癌に有用な脂質ナノ粒子2020
- Inventor(s)
  原島秀吉、マハムドヨニス、イクラミカリル
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2019
- Inventor(s)
  原島秀吉、イブラヒム　イクラミ　カリル、木村誠悟
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-116594
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質膜構造体、脂質膜構造体の製造方法および1の目的物質を1枚の脂質膜で封入する方法2012
- Inventor(s)
  原島秀吉、山田勇磨、鈴木亮佑
- Industrial Property Rights Holder
  原島秀吉、山田勇磨、鈴木亮佑
- Filing Date
  2012-02-24
- Overseas
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 結合剤およびその利用2012
- Inventor(s)
  原島秀吉、林泰弘、秋田英万、鳥谷部尚之、富樫亮平
- Industrial Property Rights Holder
  原島秀吉、林泰弘、秋田英万、鳥谷部尚之、富樫亮平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-174272
- Filing Date
  2012-08-06
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 核移行性を有する脂質膜構造体2011
- Inventor(s)
  原島秀吉、秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2011-04-10
- Overseas
- Data Source
  KAKENHI-PROJECT-22659006
[Patent] 核内移行性を有する脂質膜構造体2011
- Inventor(s)
  原島秀吉, 秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
- Industrial Property Rights Holder
  原島秀吉,秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
- Filing Date
  2011-04-20
- Overseas
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 細胞内動態を改善したカチオン性脂質2011
- Inventor(s)
  丹下耕太、新井将也、久保和弘、秋田英万、原島秀吉、畠山浩人、石破諒平、鵜川真実
- Industrial Property Rights Holder
  丹下耕太、新井将也、久保和弘、秋田英万、原島秀吉、畠山浩人、石破諒平、鵜川真実
- Industrial Property Number
  2011-252309
- Filing Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 核内移行性を有する脂質膜構造体2011
- Inventor(s)
  原島秀吉,秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗、権利者
- Filing Date
  2011-04-20
- Overseas
- Data Source
  KAKENHI-PROJECT-22659006
[Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010
- Inventor(s)
  原島秀吉, 秋田英万, 畠山浩人, 他
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Number
  2010-039667
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] 核内移行性を有する脂質膜構造体2010
- Inventor(s)
  原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学国立大学法人京都大学
- Filing Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010
- Inventor(s)
  原島秀吉、秋田英万、畠山浩人、他
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-18109001
[Patent] 核内移行性を有する脂質膜構造体2010
- Inventor(s)
  原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学国立大学法人京都大学
- Filing Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-22659006
[Patent] 機能性ポリペプチドお呼び当該ポリペプチドで就職された脂質膜構造体2010
- Inventor(s)
  原島秀吉, 秋田英万、榎戸薫、畠山浩人、桜井遊
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] 脂質膜構造体に細胞透過能を付与するペプチドと結合した脂質を構成脂質として含む、細胞透過能を有する脂質膜構造体.2009
- Inventor(s)
  原島秀吉, 秋田英万、藤原孝博
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-12-14
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 脂質膜構造体2009
- Inventor(s)
  原島秀吉, 秋田英万、アイマンエルサイド、増田智也
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20659020
[Patent] 脂質膜構造体2009
- Inventor(s)
  原島秀吉, 秋田英万、アイマンエルサイド、増田智也
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] 核輸送性脂質膜構造体2009
- Inventor(s)
  原島秀吉, 増田智也、秋田英万、西尾崇、新倉謙一、居城邦治
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20659020
[Patent] 高分子化合物またはその複合体の細胞透過性評価装置及びその細胞透過性評価方法.2009
- Inventor(s)
  原島秀吉, 秋田英万、藤原孝博、田畑泰彦
- Industrial Property Rights Holder
  北海道大学、京都大学
- Filing Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 脂質膜構造体2009
- Inventor(s)
  原島秀吉, 秋田英万、アイマンエルサイド、増田智也
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] オリゴアルキレングリコール修飾された脂質膜構造体2008
- Inventor(s)
  原島秀吉,増田智也、秋田英万、居城邦治、新倉謙一、西尾崇
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 腫瘍組織で選択的に分解性を示す血中滞留性素子2008
- Inventor(s)
  秋田英万, 畠山浩人, 原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Filing Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] 2型糖尿病診断用キット2008
- Inventor(s)
  原島秀吉、紙谷浩之、桑島正道
- Industrial Property Rights Holder
  北海道大学
- Acquisition Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 2型糖尿病の診断方法2008
- Inventor(s)
  原島秀吉, 紙谷浩之, 桑島正道
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2008-08-11
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 脂質膜構造体2008
- Inventor(s)
  原島秀吉,増田智也、秋田英万、石原一彦、金野智浩
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 腫瘍選択的分解性を示す血中滞留性素子2007
- Inventor(s)
  秋田英万・畠山浩人・長崎幸夫・大石基・菊池寛・小林英夫・原島秀吉
- Industrial Property Rights Holder
  北海道大学、筑波大学、塩野義製薬株式会社
- Filing Date
  2007-07-25
- Overseas
- Data Source
  KAKENHI-PROJECT-18015004
[Patent] 2型糖尿病診断剤2007
- Inventor(s)
  原島秀吉、飯田慎也、紙谷浩之、林泰弘、馬場嘉信
- Industrial Property Rights Holder
  北海道大学, 名古屋大学
- Industrial Property Number
  2007-072563
- Filing Date
  2007-03-20
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 目的物質をミトコンドリア内に送達可能な脂質膜構造体2006
- Inventor(s)
  山田勇磨, 秋田英万, 小暮健太朗, 紙谷浩之, 原島秀吉, 菊池寛, 小林英夫
- Industrial Property Rights Holder
  北海道大学, 第一製薬株式会社
- Filing Date
  2006-03-09
- Data Source
  KAKENHI-PROJECT-17659039
[Patent] 粒子を脂質膜で被覆する方法2006
- Inventor(s)
  小暮健太朗、箕浦ありさ、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2006-01-18
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 粒子を脂質膜で被覆する方法.2005
- Inventor(s)
  小暮健太朗, 箕浦ありさ, 原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2005-010998
- Filing Date
  2005-01-18
- Data Source
  KAKENHI-PROJECT-17016005
[Patent] 粒子を脂質膜で被覆する方法.2005
- Inventor(s)
  小暮健太朗, 箕浦ありさ, 原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2005-010998
- Filing Date
  2005-01-18
- Data Source
  KAKENHI-PROJECT-17659039
[Patent] 核酸の細胞内送達効率または細胞内発現効率を向上させた組成物.2005
- Inventor(s)
  小暮健太朗, 森口留美子, 原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2005-061677
- Filing Date
  2005-03-04
- Data Source
  KAKENHI-PROJECT-17016005
[Patent] 腫瘍組織で選択的に分解性を示す血中滞留性素子.2005
- Inventor(s)
  秋田英万, 畠山浩人, 長崎幸夫, 菊池寛, 小林英夫, 原島秀吉
- Industrial Property Rights Holder
  北海道大学, 第一製薬, 筑波大学
- Industrial Property Number
  2005-050708
- Filing Date
  2005-02-25
- Data Source
  KAKENHI-PROJECT-17016005
[Patent] 目的物質をミトコンドリア内に送達可能な脂質膜構造体.2005
- Inventor(s)
  山田勇磨, 秋田英万, 小暮健太朗, 紙谷浩之, 原島秀吉, 菊池寛, 小林英夫
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2005-066385
- Filing Date
  2005-03-09
- Data Source
  KAKENHI-PROJECT-17659039
[Patent] リボソーム封入物質がエンドソームから脱出可能なリポソーム2004
- Inventor(s)
  茶木伸治, 小暮健太朗, 二木史朗, 原島秀吉
- Industrial Property Rights Holder
  科学技術振興機構
- Industrial Property Number
  2004-205217
- Filing Date
  2004-07-12
- Data Source
  KAKENHI-PROJECT-16023201
[Patent] リポソーム封入物質がエンドソームから脱出可能なリポソーム2004
- Inventor(s)
  茶木伸治, 小暮健太朗, 二木史朗, 原島秀吉
- Industrial Property Rights Holder
  科学技術振興機構
- Industrial Property Number
  2004-205217
- Filing Date
  2004-07-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Patent] 核移行性を有する二枚膜構造遺伝子封入体の構築技術2004
- Inventor(s)
  原島秀吉
- Filing Date
  2004-03-24
- Data Source
  KAKENHI-PROJECT-15300151
[Patent] 2型糖尿病の診断方法2004
- Inventor(s)
  原島秀吉, 佐藤雄一郎, 馬場嘉信
- Industrial Property Rights Holder
  北海道TLO
- Industrial Property Number
  2004-073597
- Filing Date
  2004-03-15
- Data Source
  KAKENHI-PROJECT-16012201
[Patent] 2型糖尿病の診断方法2004
- Inventor(s)
  原島秀吉, 佐藤雄一郎, 馬場嘉信
- Industrial Property Rights Holder
  北海道TLO
- Industrial Property Number
  2004-073597
- Filing Date
  2004-03-15
- Data Source
  KAKENHI-PROJECT-14657612
[Patent] 核移行能を有するポリアルギニン修飾リポソーム2004
- Inventor(s)
  原島秀吉, 二木史朗, 小暮健太朗
- Industrial Property Rights Holder
  科学技術振興機構
- Filing Date
  2004-10-01
- Data Source
  KAKENHI-PROJECT-16023201
[Patent] 核移行能を有するポリアルギニン修飾リポソーム2003
- Inventor(s)
  原島秀吉, 二木史朗, 小暮健太朗
- Industrial Property Rights Holder
  科学技術振興機構
- Industrial Property Number
  2003-343857
- Filing Date
  2003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Patent] 細胞に導入した核酸の標的オルガネラにおける局在量を定量する方法2003
- Inventor(s)
  原島秀吉, 秋田英万
- Industrial Property Rights Holder
  科学技術振興機構
- Industrial Property Number
  2003-193038
- Filing Date
  2003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Patent] SUV型リポソームの膜融合を利用した遺伝子等の新規封入技術
- Inventor(s)
  原島秀吉
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Patent] 核移行性を有する二枚膜構造遺伝子封入体の構築技術
- Inventor(s)
  原島秀吉
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Presentation] Multifunctional Envelope-type Nano Device for gene delivery: Concept and Clinical Application for Nanomedicine.2020
- Author(s)
  Harashima H
- Organizer
  The 43rd Online KAST International Symposium “New Horizons of Nanobiological Therapeutics”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Nucleic Acid Drugs and Nanomedicine: Multifunctional Envelope-type Nano Device for Nanomedicine2020
- Author(s)
  Hideyoshi Harashima, Yusuke Sato, Takashi Nakamura, Yuma Yamada
- Organizer
  The 79 Annual Meeting of the Japanese Cancer Association.
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 脂質ナノ粒子の特性がリンパ節送達とリンパ節内分布へ与える影響2020
- Author(s)
  中村孝司、河合美典、佐藤悠介、真栄城正寿、渡慶次学、原島秀吉
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] A Mitochondrial DDS Towards An Innovative Therapy.2020
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  2020 Annual Meeting & Exposition of the Controlled Release Society. “Rising Suns from Japanese Society of Drug Delivery System”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] BCG-CWS搭載脂質ナノ粒子の全身投与型がんアジュバントへの応用2020
- Author(s)
  中村孝司、増田秀幸、野間洋輔、原島秀吉
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] MITO-Porter, a cutting-edge mitochondrial DDS.2020
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  Pharmaceutical Society of Korea 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] TLR3 adjuvant-loaded liposome induce robust antitumor activity and reduces systemic inflammation following intravenous administration.2019
- Author(s)
  Haloho S, Nakamura T, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Liposomal delivery of TLR3 agonist induces robust antitumor activity without systemic inflammation following intravenous administration.2019
- Author(s)
  Haloho S, Nakamura T, Harashima H.
- Organizer
  The 48th Annual Scientific Meeting of the Australian and New Zealand Society for Immunology (ASI) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Multifunctional Envelope-type Nano Device for Nucleic Acids/Gene Delivery2019
- Author(s)
  Harashima Hideyoshi
- Organizer
  Bio Incheon Global Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Efficient delivery of macromolecules by molecular design of cationic lipids2019
- Author(s)
  Sato Y, Hashiba K, Hashiba A, Okabe N, Harashima H
- Organizer
  Liposome Research Days 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] MITO-Porter, liposomal mitochondrial delivery system: Toward Mitochondrial Nanomedicine2019
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  Liposome Research Days 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Multifunctional Envelope-type Nano Device for Gene/Nucleic acids Delivery: Concept and Application to Nanomedicine2019
- Author(s)
  Harashima Hideyoshi
- Organizer
  15th US-Japan DDS Symposium.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 多機能性エンベロープ型ナノ構造体の開発とナノ医療への展開：日本薬剤学会・日本薬学会合同シンポジウム　脂質・細胞製剤の新展開2019
- Author(s)
  原島秀吉
- Organizer
  日本薬剤学会第34回年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] DNAマイクロアレイとin vivo siRNA送達システムの融合による新規2型糖尿病治療薬創出2013
- Author(s)
  末光永理奈、林泰弘、梶本和昭、佐藤悠介、Afsana Akhter、櫻井遊、畠山浩人、兵藤守、加地範匡、馬場嘉信、原島秀吉
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋 (ウインクあいち)
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] An approach to mitochondrial genesilencing by the mitochondrial delivery of anti-sense RNA2013
- Author(s)
  Y. Yamada, R. Furukawa, E. Kawamura, H. Harashima
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] ミトコンドリアを標的とした遺伝子発現制御の試み2013
- Author(s)
  山田勇磨、古川亮、原島秀吉.
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋 (ウインクあいち)
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] 膵β細胞株MIN6細胞を標的としたDDS, β-MENDの構築および核酸導入・機能発現の検証2013
- Author(s)
  田端麻衣、山田勇磨、安崎友香理、野村政壽、柴田篤志、佐々木茂樹、原島秀吉
- Organizer
  日本薬学会北海道支部第140回例会
- Place of Presentation
  札幌(札幌コンベンションセンター)
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides2013
- Author(s)
  E. Kawamura, Y. Yamada, H. Harashima
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] A new approach for innovative nanomedicine of type 2 diabetes in combination with DNA microarray and in vivo siRNA delivery2013
- Author(s)
  Suemitsu E, Hayashi Y, Kajimoto K, Sato Y, Akhter A, Sakurai Y, Hatakeyama H, Hyodo M, Harashima H,
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-21229002
[Presentation] Technologies in Gene Delivery for Nanomedicines2012
- Author(s)
  Hideyoshi Harashima, Breakthrough
- Organizer
  FIP Centennial, 2012
- Place of Presentation
  Amsterdam, the Netherlands, Amsterdam RAI
- Year and Date
  2012-10-08
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 3rd Asian Biomaterials Congress
- Place of Presentation
  BEXCO Busan (Korea)(招待講演)
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Controlled Intracellular trafficking of Non-viral Vectors2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 14th Annual Meeting of ASGCT Scientific Symposium Gene & Cell Therapy Around the Globe : A Showcase of Asia
- Place of Presentation
  Washington State Convention & Trade Center (USA)(招待講演)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] DDS製剤の臨床応用への課題、DDS製剤の臨床応用を目指して2011
- Author(s)
  原島秀吉
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀(東京)(招待講演)
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  Joint Meeting of the Austrian and German Pharmaceutical Sciences
- Place of Presentation
  University of Innsbruck (Austria)(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] KALA-modified multi-layered nano particles as antigen gene carrier for MHC Class-I mediated antigen presentation in DNA vaccine approach2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yanashita A, Katoono R, Yui N, Harashima H
- Organizer
  38th Annual Meeting & Exposition of the Controlled Release Society (CRS)
- Place of Presentation
  Gaylord National Hotel and Convention Center (U.S.A.)
- Year and Date
  2011-08-02
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery : Concept and Application for Nanomedicine2011
- Author(s)
  Harashima H
- Organizer
  Joint Meeting of the Austrian and German PharmaceuticalSciences
- Place of Presentation
  University of Innsbruck (Austria)(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011
- Author(s)
  原島秀吉
- Organizer
  第40回日本免疫学会学術集会関連分野セミナー
- Place of Presentation
  幕張メッセ(千葉)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery: Concept and Application for Nanomedicine2011
- Author(s)
  Hideyoshi Harashima
- Organizer
  Joint Meeting of the Austrian and German Pharmaceutical Sciences
- Place of Presentation
  Innsbruck, Austria, University of Innsbruck
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] バイオイメージングで可視化するナノメディシンの世界～多機能性エンベロープ型ナノ構造体が拓く遺伝子治療への道～2011
- Author(s)
  原島秀吉
- Organizer
  第20回日本バイオイメージング学会学術集会
- Place of Presentation
  千歳科学技術大学(北海道)(招待講演)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] 多機能性エンベロープ型ナノ構造体の創製とナノメディシンへの展開2011
- Author(s)
  原島秀吉
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Concept and Application of MEND2010
- Author(s)
  Hideyoshi Harashima, Nanotechnology for In Vivo Gene Delivery
- Organizer
  2010 FIP PSWC/AAPS Annual Meeting and Exposition, Short Course: Nanotechnology from A to Z: Achievement in Drug Delivery and Tissue Engineering
- Place of Presentation
  New Orleans, U. S. A. Ernest N. Morial Convention Center
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] 多機能性エンベロープ型ナノ構造体による次世代医薬への新たな展開2010
- Author(s)
  原島秀吉
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島招待講演
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] MENDで拓く創薬への道2010
- Author(s)
  原島秀吉
- Organizer
  金沢大学薬学シンポジウム2010創薬動態フォーラムin金沢
- Place of Presentation
  金沢大学角間キャンパス金沢招待講演
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application for nanomedicine2009
- Author(s)
  Hideyoshi Harashima
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  Centennial Hall Kyushu University, Fukuoka, Japan
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Multifunctional envelope-type nano device for non-viral gene delivery : Concept and application of programmed packaging2009
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 8^<th> Cerebral Vascular Biology 2009
- Place of Presentation
  Sendai Excel Hotel Tokyu, Sendai, Japan
- Year and Date
  2009-07-01
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Multifunctional envelope-type nano device for non-viral gene delivery: Concept and application for nanomedicine2009
- Author(s)
  H. Harashima
- Organizer
  Asian Federation for Pharmaceutical Sciences 2009
- Place of Presentation
  Hakata, Japan(invited)
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Multifunctional envelope-type Nano Device for in vivo systemic delivery of siRNA2008
- Author(s)
  H. Harashima
- Organizer
  68th International Congres of FIP
- Place of Presentation
  Basel, Switzerland(invited)
- Year and Date
  2008-09-02
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Controlled Intracellular Trafficking of Non-viral Vector.2008
- Author(s)
  H.Harashima
- Organizer
  The 10th Annual Meeting of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy.
- Place of Presentation
  Seatle.Washington.USA
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] 血液サンプルを用いた2型糖尿病の遺伝子診断システムの開発2007
- Author(s)
  林泰弘、飯田慎也、中谷明弘、澤田章弘、加地範匡、紙谷浩之、馬場嘉信、原島秀吉
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  大宮(大宮ソニックシティ)
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  第23会日本DDS学会
- Place of Presentation
  熊本
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007
- Author(s)
  H.Harashima
- Organizer
  13th International Symposium on Recent Advances in Drug Delivery Systems
- Place of Presentation
  Salt Lake City.Utah.USA.
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] 血管内皮細胞標的化ペプチド搭載リポソームの細胞内取り込み機構の解析2007
- Author(s)
  秋田英万、ディッキー・ムダキュル、タン・エルダル、原島秀吉
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  大宮(大宮ソニックシティ)
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-20015003
[Presentation] A Multi-functional envelope type nano device as an anti-tumor gene delivery system2007
- Author(s)
  原島秀吉
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18015004
[Presentation] Multifunctional envelope type nano device for non-viral gene delivery: Concept and application of Programmed Packaging2007
- Author(s)
  H. Harashima
- Organizer
  13th International Symposium on Recent Advances in Drug Delivery Systems
- Place of Presentation
  Salt Lake City, Utah, USA.(invited)
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Cellular uptake mechanism and intracellular trafficking study of the novel C152-peptide-modified liposomes(C152-Lip)2007
- Author(s)
  ディッキームダキュル、秋田英万、タンエルダル、原島秀吉
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本(熊本日航ホテル)
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  第23回日本DDS学会永井賞受賞講演
- Place of Presentation
  熊本(invited)
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉
- Organizer
  日本薬学会第127年会(学術振興賞受賞講演)
- Place of Presentation
  富山(invited)
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Controlled Intracellular Trafficking of Non-viral Vector2007
- Author(s)
  H. Harashima
- Organizer
  The 10th Annual Meeing of American Society of Gene Therapy: Education Session: Topical Review: Non-viral Vector esign and Efficacy
- Place of Presentation
  Seatle, Washington, USA
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines
- Author(s)
  Hideyoshi Harashima
- Organizer
  FIP Centennial, 2012
- Place of Presentation
  Amsterdam RAI, Amsterdam, The Netherland
- Invited
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Multifunctional Envelope-type Nano Device as gene delivery system for Nanomedicine
- Author(s)
  Hideyoshi Harashima
- Organizer
  The 10th France - Japan DDS Symposium
- Place of Presentation
  Grande Hotel de Bordeaux, Bordeaux, France
- Invited
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Multifunctional Envelope-type Nano Device for Non-viral Gene Delivery
- Author(s)
  Hideyoshi Harashima
- Organizer
  IBS 2012 15th International Biotechnology Symposium and Exhibition
- Place of Presentation
  EXCO Daegu, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Breakthrough Technologies in Gene Delivery for Nanomedicines
- Author(s)
  Hideyoshi Harashima
- Organizer
  FIP Centennial, 2012
- Place of Presentation
  Amsterdam RAI (The Netherlands)
- Invited
- Data Source
  KAKENHI-PROJECT-22659006

1. KAMIYA Hiroyuki (10204629)

# of Collaborated Projects: 10 results

# of Collaborated Products: 10 results
2. AKITA Hidetaka (80344472)

# of Collaborated Projects: 8 results

# of Collaborated Products: 32 results
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Harashima Hideyoshi 原島 秀吉

原島 秀吉 ハラシマ ヒデヨシ

HARASHIMA Hideyoshi 原島 秀吉

Research Projects

Research Products

Co-Researchers

Strategic creation of polymer-lipid hybrid nanoparticles for tissue-selective nucleic acid delivery

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Development of gene delivery systems for liver diseases treatment and cancer treatmentHost Researcher

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Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking stepsPrincipal Investigator

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ＢＣＧ搭載ナノ粒子の細胞内動態制御に基づいた革新的膀胱癌治療システムの創製Principal Investigator

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Development of a new type of anti-tuberculosis vaccines by the use of lipid immunity

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MENDで拓く遺伝子治療への道：遺伝子の運び屋からナノマシンへPrincipal Investigator

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Programmed Activationに基づく人工DNAワクチンの創製Principal Investigator

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Novel gene delivery system with switch functionPrincipal Investigator

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Study on the innovative molecular-targeting medicine based on the nano-DDS encapsulating intelligent artificial oligonucleotides

Principal Investigator

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Developent of glycolipid vaccines against tuberculos is

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Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapyPrincipal Investigator

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抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチンPrincipal Investigator

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がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用Principal Investigator

Principal Investigator

Harashima Hideyoshi 原島秀吉

原島秀吉ハラシマヒデヨシ

HARASHIMA Hideyoshi 原島秀吉