KASAHARA YUUYA 笠原勇矢

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Kasahara Yuuya 笠原勇矢

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Researcher Number	10740673
Other IDs
Affiliation (Current)	2026: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, 副センター長
Affiliation (based on the past Project Information) *help	2023 – 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, 副センター長 2020 – 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, サブプロジェクトリーダー
Review Section/Research Field	Principal Investigator Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 37010:Bio-related chemistry Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 53010:Gastroenterology-related / Basic Section 62010:Life, health and medical informatics-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Transformative Research Areas, Section (II) / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator アンチセンス核酸 / 人工核酸 / アプタマー / BBBモデル / DDS / 核酸医薬 / ポリメラーゼ / SELEX Except Principal Investigator 核酸医薬 / コンパニオン診断 … More / アンチセンス核酸医薬 / アンチセンスオリゴ / 肝細胞癌 / 肝癌由来増殖因子 / 人工核酸 / 分子動力学計算 / 人工核酸アプタマー / アンチセンス核酸 / Transcriptome解析 / オフターゲット探索 / 血行性転移 / 転移 / 食道癌 / 人工修飾型核酸 / アンチセンス / HDGF / 深層学習 / 改変ポリメラーゼ / RN7SL1 / デザイナー細胞 / 小胞体(ER)ストレス / 環状RNA / CAR-マクロファージ / 細胞膜透過 / 膜モジュレータ / 細胞接着因子 / PCDHA11 / 胃癌 / 人工修飾核酸 / 機械学習 / デザイン / アプタマー / SELEX / ドッキング / 高機能性人工核酸 / 癌治療核酸医薬 / 消化器癌 Less

Development of functional nucleic acid molecules using a blood-brain barrier modelPrincipal Investigator
- Principal Investigator
  
  笠原勇矢
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
環状RNA搭載型CAR-M療法による画期的な難治がん治療技術の開発
- Principal Investigator
  
  原知明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Osaka
タンパク質の深層学習を用いた改変ポリメラーゼデザイン法の開発
- Principal Investigator
  
  長尾知生子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  The University of Osaka
肝癌由来増殖因子を標的とした核酸医薬品の構造最適化：肝細胞癌の新規治療薬の創出
- Principal Investigator
  
  Hirayuki Enomoto
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hyogo Medical University
Development of New Treatment for Cancer Using Dual-Modified Antisense Nucleic Acids Targeting Cell Adhesion Factors
- Principal Investigator
  
  Kodera Yasuhiro
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  National Hospital Organization Nagoya Medical Center
  Nagoya University
核酸の膜透過を誘導するリン酸部修飾の探索と膜モジュレータ分子の機能評価
- Principal Investigator
  
  大澤昂志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Osaka
食道癌転移の分子病態解明にもとづいたデュアル修飾型アンチセンス核酸医薬創出研究
- Principal Investigator
  
  神田光郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagoya University
Development of a new design method for artificial nucleic acids
- Principal Investigator
  
  Nagao Chioko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Osaka University
Development of artificial nucleic acid aptamers to improve the efficacy of antisense oligonucleotidePrincipal Investigator
- Principal Investigator
  
  Kasahara Yuuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Development of a new therapeutic agent for hepatocellular carcinoma targeting the hepatocarcinoma-derived growth factor by applying nucleic acid medicine
- Principal Investigator
  
  Hirayuki Enomoto
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hyogo Medical University
Development of amido-bridged nucleic acid-modified antisense oligonucleotides to treat gastrointestinal malignancies
- Principal Investigator
  
  KANDA Mitsuro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nagoya University

All 2025 2024 2023 2022 2021

All Journal Article Presentation Book

[Book] 医薬品モダリティにおける創薬技術開発と展望2024
- Author(s)
  笠原勇矢
- Total Pages
  286
- Publisher
  情報機構
- Data Source
  KAKENHI-PLANNED-24H00840
[Journal Article] In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity2024
- Author(s)
  Osawa Takashi、Kita Ryosuke、Kasahara Yuuya、Yamaguma Harumi、Nakayama Taisuke、Kamada Haruhiko、Obika Satoshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 110 Pages: 117814-117814
- DOI
  10.1016/j.bmc.2024.117814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24H00839, KAKENHI-PLANNED-24H00840, KAKENHI-PROJECT-23K04930
[Journal Article] Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer2024
- Author(s)
  Kanda Mitsuro、Kasahara Yuuya、Shimizu Dai、Shinozuka Takahiro、Sasahara Masahiro、Nakamura Shunsuke、Iguchi Yohei、Katsuno Masahisa、Kodera Yasuhiro、Obika Satoshi
- Journal Title
  
  British Journal of Cancer
  
  Volume: 131 Issue: 9 Pages: 1555-1566
- DOI
  10.1038/s41416-024-02859-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21445
[Journal Article] Light-controllable cell-membrane disturbance for intracellular delivery2024
- Author(s)
  Huo Wenting、Miki Koji、Mu Huiying、Osawa Takashi、Yamaguma Harumi、Kasahara Yuuya、Obika Satoshi、Kawaguchi Yoshimasa、Hirose Hisaaki、Futaki Shiroh、Miyazaki Yusuke、Shinoda Wataru、Akai Shuji、Ohe Kouichi
- Journal Title
  
  Journal of Materials Chemistry B
  
  Volume: in press Issue: 17 Pages: 4138-4147
- DOI
  10.1039/d3tb02956e
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20530, KAKENHI-ORGANIZER-24H00839, KAKENHI-PLANNED-24H00840, KAKENHI-PLANNED-24H00843, KAKENHI-PROJECT-23KJ1297
[Journal Article] Systematic Analysis of 2′-O-Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties2023
- Author(s)
  Ishida Kenta、Kasahara Yuuya、Hoshino Hidekazu、Okuda Takumi、Obika Satoshi
- Journal Title
  
  Molecules
  
  Volume: 28 Issue: 23 Pages: 7911-7911
- DOI
  10.3390/molecules28237911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K15702, KAKENHI-PROJECT-21K14743
[Journal Article] Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity2021
- Author(s)
  Uemachi Hiro、Kasahara Yuuya、Tanaka Keisuke、Okuda Takumi、Yoneda Yoshihiro、Obika Satoshi
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 6 Pages: 888-888
- DOI
  10.3390/pharmaceutics13060888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] KOD DNAポリメラーゼ変異体による5′位アルキル修飾チミジン誘導体を含むオリゴ核酸の酵素合成2025
- Author(s)
  石田健太、星野秀和、山口卓男、小比賀聡、笠原勇矢
- Organizer
  日本化学会第105春季年会(2025)
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] RNA分解誘導型アンチセンス核酸開発基盤の構築と難治性疾患への創薬展開2025
- Author(s)
  笠原勇矢
- Organizer
  日本薬学会第145年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] フィンガードメインにおけるDNAポリメラーゼの変異が修飾ヌクレオチドの取り組みに及ぼす効果2025
- Author(s)
  田澤駿、片岡由佳、星野秀和、石田健太、笠原勇矢、小比賀聡、桒原正靖
- Organizer
  日本化学会第105春季年会(2025)
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 宿主因子標的型アンチセンス核酸による新規抗インフルエンザ薬の開発2025
- Author(s)
  下岡誠、桐野友美、山隈晴美、宮崎日菜、安齋樹、七戸新太郎、小比賀聡、笠原勇矢、渡辺登喜子
- Organizer
  日本薬学会第145年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] アンチセンス核酸の活性を向上するジペプチドリガンドの探索を目的としたin vitroスクリーニング2025
- Author(s)
  大澤昂志;喜多良介;山隈晴美;笠原勇矢;小比賀聡
- Organizer
  日本薬学会第145年会
- Invited
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] マンノシルエリスリトールリピッド含有LNPの合成と核酸導入活性2025
- Author(s)
  伊波美鈴、安齋樹、渡辺登喜子、阿曽古都美、笠原勇矢、戸嶋一敦、高橋大介
- Organizer
  日本化学会第105春季年会(2025)
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] Tm-Value Prediction Model Construction of AmNA-Containing Gapmer Antisense Oligonucleotide2024
- Author(s)
  Masataka Kuroda, Yuuya Kasahara, Masako Hirose, Harumi Yamaguma, Masayuki Oda, Chioko Nagao and Kenji Mizuguchi
- Organizer
  Asia & Pacific Bioinformatics Joint Conference 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 塩基修飾におけるリンカーアーム構造がDNAポリメラーゼ反応の効率に及ぼす影響2024
- Author(s)
  片岡由佳、永谷恵梨佳、星野秀和、笠原勇矢、小比賀聡、桒原正靖
- Organizer
  第18回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] Masataka Kuroda, Yuuya Kasahara, Masako Hirose, Harumi Yamaguma, Masayuki Oda, Chioko Nagao and Kenji Mizuguchi、A Tm-value prediction system and molecular dynamics analysis of AmNA-containing gapmer antisense oligonucleotides2024
- Author(s)
  Masataka Kuroda, Yuuya Kasahara, Masako Hirose, Harumi Yamaguma, Masayuki Oda, Chioko Nagao and Kenji Mizuguchi
- Organizer
  Brazilian Symposium on Bioinformatics 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 高活性かつ低毒性なRNA分解誘導型アンチセンス核酸を迅速・高確度に創出可能な配列設計技術の開発2024
- Author(s)
  笠原勇矢、山隈晴美、亀岡なつ実、小比賀聡
- Organizer
  第74回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 胃癌腹膜播種治療に向けたSYT13標的アンチセンス核酸の非臨床安全性試験2024
- Author(s)
  笠原勇矢、神田光郎、清水大、小比賀聡
- Organizer
  日本核酸医薬学会第9回年会若手シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] アミド結合あるいはグアニジノ基を架橋部位に有する糖部架橋型人工核酸を伸長可能な改変ポリメラーゼの開発と性能評価2024
- Author(s)
  星野秀和、小比賀聡、笠原勇矢
- Organizer
  日本核酸医薬学会第9回年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] ンチセンス核酸の核への送達を志向した核移行性アプタマーの開発2024
- Author(s)
  仁田峠海斗、石田健太、星野秀和、宮本洋一、小比賀聡、笠原勇矢
- Organizer
  日本核酸医薬学会第9回年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] デュアル修飾型核酸導入オリゴ核酸の酵素合成条件探索と正確性に関する検証2024
- Author(s)
  仁田峠海斗、石田健太、星野秀和、笠原勇矢、小比賀聡
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] A novel selection method generating nuclear localization aptamers2024
- Author(s)
  Kaito Nitatouge, Kenta Ishida, Hidekazu Hoshino, Yuuya Kasahara, Satoshi Obika
- Organizer
  20th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS) 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] Gapmer型アンチセンス核酸のLNA導入パターンが標的RNAとの結合速度およびターンオーバーステップにおける標的RNA置換速度に与える影響2024
- Author(s)
  尾田ちひろ、笠原勇矢、小比賀聡
- Organizer
  日本核酸医薬学会第9回年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 胃癌腹膜播種治療に向けたSYT13標的アンチセンス核酸の非臨床安全性試験2024
- Author(s)
  笠原勇矢、神田光郎、清水大、小比賀聡
- Organizer
  日本核酸医薬学会第9回年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 新規TRPC3/C6（Transient Receptor Potential C3/C6）チャネル選択的活性化剤L687によるアンチセンス核酸の細胞内取り込み亢進2024
- Author(s)
  永田龍、小橋博人、為則裕介、尼谷明日路、植田誉志文、森泰生、笠原勇矢、小比賀聡、下條正仁
- Organizer
  日本核酸医薬学会第9回年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] Development of the polymerase mutants towards screening of functional oligonucleotides using bridged nucleic acids containing an amide bond or a guanidino group2024
- Author(s)
  Hidekazu Hoshino, Yuuya Kasahara, Satoshi Obika
- Organizer
  20th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS) 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 人工核酸アンチセンスオリゴDNAを用いたがん細胞選択的なシスプラチン増感剤としてのMCM8阻害剤の創出2024
- Author(s)
  内堀友紀、末國雅貴、小梶優子、吉田和真、笠原勇矢、藤田雅俊
- Organizer
  第47回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] 悪性脳腫瘍における発癌性因子RESTに対するギャップマー型アンチセンス核酸の開発2024
- Author(s)
  爲則裕介、笠原勇矢、下條正仁、小比賀聡
- Organizer
  第83回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] Ugi反応を基盤とした化学修飾ジペプチド-アンチセンス核酸コンジュゲートライブラリーの合成とin vitro活性評価2024
- Author(s)
  大澤昂志;喜多良介;山隈晴美;笠原勇矢;小比賀聡
- Organizer
  オリゴ核酸への導入効率向上を目指した架橋型人工核酸ENAアミダイトの合成
- Data Source
  KAKENHI-PLANNED-24H00840
[Presentation] ポリアミンによる人工核酸の酵素伸長への影響2023
- Author(s)
  星野秀和、笠原勇矢、小比賀聡
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] 抗IL-6Rアプタマーの構造最適化に向けた核酸分解酵素の利用2023
- Author(s)
  石田健太、千賀陽子、長尾知生子、新山真由美、鎌田春彦、水口賢司、小比賀聡、笠原勇矢
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-21K12125
[Presentation] 血液脳関門モデルを用いた人工核酸アプタマーの探索2023
- Author(s)
  千賀陽子、山口朋子、星野秀和、小比賀聡、川端健二、笠原勇矢
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] 抗IL-6Rアプタマーの構造最適化に向けた核酸分解酵素の利用2023
- Author(s)
  石田健太、千賀陽子、長尾知生子、新山真由美、鎌田春彦、水口賢司、小比賀聡、〇笠原勇矢
- Organizer
  日本核酸医薬学会第8回年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] 糖・塩基部デュアル修飾型人工核酸を用いた抗CHIP/STUB1アプタマーの創出2023
- Author(s)
  石田健太、千賀陽子、仁田峠海斗、岡正啓、大岡伸通、星野秀和、出水庸介、井上貴雄、小比賀聡、笠原勇矢
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] Enzymatic synthesis of several 2′-O-alkyl modified oligonucleotides with wide range of hydrophobicity2023
- Author(s)
  Ishida K., Hoshino H., Obika S., Kasahara Y.
- Organizer
  The 50th International Symposium on Nucleic Acids Chemistry/The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] ランダム領域を拡張した修飾オリゴヌクレオチドの酵素合成2023
- Author(s)
  仁田峠海斗、石田健太、星野秀和、笠原勇矢、小比賀聡
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] アプタマー創薬を志向した2′-MOEオリゴ核酸の酵素合成2022
- Author(s)
  石田健太, 笠原勇矢, 星野秀和, 米田悦啓, 小比賀聡
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] ランダム領域を拡張した修飾オリゴヌクレオチドの酵素合成2022
- Author(s)
  仁田峠海斗、石田健太、星野秀和、笠原勇矢、小比賀聡
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K12125
[Presentation] 塩基部修飾人工核酸を用いた抗IL-6Rアプタマーの開発2022
- Author(s)
  笠原勇矢、千賀陽子、石田健太、奥田匠、長尾知生子、新山真由美、鎌田春彦、水口賢司、小比賀聡
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] タンパク質標的型核酸医薬の新たな可能性2022
- Author(s)
  笠原勇矢
- Organizer
  第3回モダリティ創薬デザイン研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] ポリアミンによる人工核酸の酵素伸長への影響2022
- Author(s)
  星野秀和、笠原勇矢、小比賀聡
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K12125
[Presentation] Development of antagonist aptamers to interleukin-6 receptor2022
- Author(s)
  Kasahara Y., Senga Y., Ishida K., Okuda T., Nagao C., Niiyama M., Kamada H., Mizuguchi K., Obika S.
- Organizer
  The 18th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] 2′位や5′位を修飾した人工核酸の改変ポリメラーゼによる酵素伸長2022
- Author(s)
  石田健太、笠原勇矢、星野秀和、小比賀聡
- Organizer
  日本核酸医薬学会第7回年会　東京
- Data Source
  KAKENHI-PROJECT-21K12125
[Presentation] Enzymatic synthesis of oligonucleotide with 2′-MOE modification2022
- Author(s)
  Ishida K., Kasahara Y., Hoshino H., Obika S.
- Organizer
  The 18th Annual Meeting of the Oligonucleotide Therapeutics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] 糖・塩基部デュアル修飾型人工核酸を用いた抗CHIP/STUB1アプタマーの創出2022
- Author(s)
  石田健太、千賀陽子、仁田峠海斗、岡正啓、大岡伸通、星野秀和、出水庸介、井上貴雄、小比賀聡、笠原勇矢
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K12125
[Presentation] 2′位や5′位を修飾した人工核酸の改変ポリメラーゼによる酵素伸長2022
- Author(s)
  石田健太、笠原勇矢、星野秀和、小比賀聡
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] 塩基部修飾人工核酸を用いた抗IL-6Rアプタマーの開発2022
- Author(s)
  笠原勇矢、千賀陽子、石田健太、奥田匠、長尾知生子、新山真由美、鎌田春彦、水口賢司、小比賀聡
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21K12125
[Presentation] 胃がん腹膜播種治療に向けたSYT13標的アンチセンス核酸の毒性評価およびオフターゲット解析2021
- Author(s)
  笠原勇矢, 神田光郎, 山隈晴美, 亀岡なつ実, 小比賀聡
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] 人工核酸アプタマーを利用したMCM8-9阻害剤の開発2021
- Author(s)
  内堀友紀, 笠原勇矢, 真柳浩太, 杉本のぞみ, 藤田雅俊
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K14743
[Presentation] Development of xeno nucleic acid aptamers targeting the SARS-CoV-2 spike protein for COVID-19 therapeutics2021
- Author(s)
  石田健太, 笠原勇矢, 星野秀和, 小比賀聡
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-21K14743

1. KANDA Mitsuro (00644668)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 小比賀聡 (80243252)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 清水大 (50723037)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 田中千恵 (50589786)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. Kodera Yasuhiro (10345879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. Nagao Chioko (10402463)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. Hirayuki Enomoto (40449880)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 李秀栄 (50390670)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 西川浩樹 (30769609)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 新崎信一郎 (60546860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 由利幸久 (90992933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大澤昂志 (00783226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 桑原正靖 (40334130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 細田忠弘 (31017734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山口朋子 (50580130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 原知明 (30779161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 石井秀始 (10280736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 孟思昆 (50977204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 飯島尋子 (80289066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 中西香企 (10836183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 星野秀和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MU Huiying

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KASAHARA YUUYA 笠原 勇矢

Kasahara Yuuya 笠原 勇矢

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Development of functional nucleic acid molecules using a blood-brain barrier modelPrincipal Investigator

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Development of artificial nucleic acid aptamers to improve the efficacy of antisense oligonucleotidePrincipal Investigator

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[Book] 医薬品モダリティにおける創薬技術開発と展望2024

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[Journal Article] In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity2024

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[Journal Article] Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer2024

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[Journal Article] Light-controllable cell-membrane disturbance for intracellular delivery2024

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KASAHARA YUUYA 笠原勇矢

Kasahara Yuuya 笠原勇矢