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KASAHARA YUUYA  笠原 勇矢

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Kasahara Yuuya  笠原 勇矢

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Researcher Number 10740673
Other IDs
Affiliation (Current) 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 創薬デザイン研究センター, 副センター長
Affiliation (based on the past Project Information) *help 2023 – 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 創薬デザイン研究センター, 副センター長
2020 – 2022: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 創薬デザイン研究センター, サブプロジェクトリーダー
Review Section/Research Field
Principal Investigator
Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 37010:Bio-related chemistry
Except Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 62010:Life, health and medical informatics-related / Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Transformative Research Areas, Section (II) / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords
Principal Investigator
アンチセンス核酸 / 人工核酸 / アプタマー / BBBモデル / DDS / 核酸医薬 / ポリメラーゼ / SELEX
Except Principal Investigator
コンパニオン診断 / アンチセンス核酸医薬 … More / 人工核酸 / 分子動力学計算 / 人工核酸アプタマー / Transcriptome解析 / アンチセンスオリゴ / 肝細胞癌 / 肝癌由来増殖因子 / 深層学習 / 改変ポリメラーゼ / RN7SL1 / デザイナー細胞 / 小胞体(ER)ストレス / 環状RNA / CAR-マクロファージ / 細胞接着因子 / PCDHA11 / 胃癌 / 細胞膜透過 / 核酸医薬 / 膜モジュレータ / 人工修飾核酸 / オフターゲット探索 / 血行性転移 / 食道癌 / 機械学習 / デザイン / アプタマー / SELEX / ドッキング / アンチセンス核酸 / 高機能性人工核酸 / 癌治療核酸医薬 / 消化器癌 / 人工修飾型核酸 Less
  • Research Projects

    (11 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (20 People)
  •  Development of functional nucleic acid molecules using a blood-brain barrier modelPrincipal Investigator

    • Principal Investigator
      笠原 勇矢
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
      Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  環状RNA搭載型CAR-M療法による画期的な難治がん治療技術の開発

    • Principal Investigator
      原 知明
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      The University of Osaka
  •  タンパク質の深層学習を用いた改変ポリメラーゼデザイン法の開発

    • Principal Investigator
      長尾 知生子
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      The University of Osaka
  •  食道癌転移の分子病態解明にもとづいたデュアル修飾型アンチセンス核酸医薬創出研究

    • Principal Investigator
      神田 光郎
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nagoya University
  •  肝癌由来増殖因子を標的とした核酸医薬品の構造最適化:肝細胞癌の新規治療薬の創出

    • Principal Investigator
      榎本 平之
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hyogo Medical University
  •  核酸の膜透過を誘導するリン酸部修飾の探索と膜モジュレータ分子の機能評価

    • Principal Investigator
      大澤 昂志
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      The University of Osaka
  •  核酸医薬を応用した肝癌由来増殖因子を標的とする新たな肝細胞癌治療薬の開発

    • Principal Investigator
      榎本 平之
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Hyogo Medical University
  •  Development of a new design method for artificial nucleic acids

    • Principal Investigator
      Nagao Chioko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 62010:Life, health and medical informatics-related
    • Research Institution
      Osaka University
  •  Development of artificial nucleic acid aptamers to improve the efficacy of antisense oligonucleotidePrincipal Investigator

    • Principal Investigator
      Kasahara Yuuya
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 37010:Bio-related chemistry
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  細胞接着因子を標的とするデュアル修飾型アンチセンス核酸を用いた革新的癌治療薬創出

    • Principal Investigator
      小寺 泰弘
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nagoya University
  •  Development of amido-bridged nucleic acid-modified antisense oligonucleotides to treat gastrointestinal malignancies

    • Principal Investigator
      KANDA Mitsuro
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Nagoya University

All 2023 2022 2021

All Journal Article Presentation

  • [Journal Article] Hybrid-Type SELEX for the Selection of Artificial Nucleic Acid Aptamers Exhibiting Cell Internalization Activity2021

    • Author(s)
      Uemachi Hiro、Kasahara Yuuya、Tanaka Keisuke、Okuda Takumi、Yoneda Yoshihiro、Obika Satoshi
    • Journal Title

      Pharmaceutics

      Volume: 13 Issue: 6 Pages: 888-888

    • DOI

      10.3390/pharmaceutics13060888

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] ポリアミンによる人工核酸の酵素伸長への影響2023

    • Author(s)
      星野秀和、笠原勇矢、小比賀聡
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] 抗IL-6Rアプタマーの構造最適化に向けた核酸分解酵素の利用2023

    • Author(s)
      石田健太、千賀陽子、長尾知生子、新山真由美、鎌田春彦、水口賢司、小比賀聡、笠原勇矢
    • Organizer
      日本核酸医薬学会第8回年会
    • Data Source
      KAKENHI-PROJECT-21K12125
  • [Presentation] 糖・塩基部デュアル修飾型人工核酸を用いた抗CHIP/STUB1アプタマーの創出2023

    • Author(s)
      石田健太、千賀陽子、仁田峠海斗、岡正啓、大岡伸通、星野秀和、出水庸介、井上貴雄、小比賀聡、笠原勇矢
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] ランダム領域を拡張した修飾オリゴヌクレオチドの酵素合成2023

    • Author(s)
      仁田峠海斗、石田健太、星野秀和、笠原勇矢、小比賀聡
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] アプタマー創薬を志向した2′-MOEオリゴ核酸の酵素合成2022

    • Author(s)
      石田健太, 笠原勇矢, 星野秀和, 米田悦啓, 小比賀聡
    • Organizer
      日本薬学会 第142年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] ランダム領域を拡張した修飾オリゴヌクレオチドの酵素合成2022

    • Author(s)
      仁田峠海斗、石田健太、星野秀和、笠原勇矢、小比賀聡
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-21K12125
  • [Presentation] 塩基部修飾人工核酸を用いた抗IL-6Rアプタマーの開発2022

    • Author(s)
      笠原勇矢、千賀陽子、石田健太、奥田匠、長尾知生子、新山真由美、鎌田春彦、水口賢司、小比賀聡
    • Organizer
      日本核酸医薬学会第7回年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] タンパク質標的型核酸医薬の新たな可能性2022

    • Author(s)
      笠原勇矢
    • Organizer
      第3回モダリティ創薬デザイン研究会シンポジウム
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] ポリアミンによる人工核酸の酵素伸長への影響2022

    • Author(s)
      星野秀和、笠原勇矢、小比賀聡
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-21K12125
  • [Presentation] Development of antagonist aptamers to interleukin-6 receptor2022

    • Author(s)
      Kasahara Y., Senga Y., Ishida K., Okuda T., Nagao C., Niiyama M., Kamada H., Mizuguchi K., Obika S.
    • Organizer
      The 18th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] 2′位や5′位を修飾した人工核酸の改変ポリメラーゼによる酵素伸長2022

    • Author(s)
      石田健太、笠原勇矢、星野秀和、小比賀聡
    • Organizer
      日本核酸医薬学会第7回年会 東京
    • Data Source
      KAKENHI-PROJECT-21K12125
  • [Presentation] Enzymatic synthesis of oligonucleotide with 2′-MOE modification2022

    • Author(s)
      Ishida K., Kasahara Y., Hoshino H., Obika S.
    • Organizer
      The 18th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] 糖・塩基部デュアル修飾型人工核酸を用いた抗CHIP/STUB1アプタマーの創出2022

    • Author(s)
      石田健太、千賀陽子、仁田峠海斗、岡正啓、大岡伸通、星野秀和、出水庸介、井上貴雄、小比賀聡、笠原勇矢
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-21K12125
  • [Presentation] 2′位や5′位を修飾した人工核酸の改変ポリメラーゼによる酵素伸長2022

    • Author(s)
      石田健太、笠原勇矢、星野秀和、小比賀聡
    • Organizer
      日本核酸医薬学会第7回年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] 塩基部修飾人工核酸を用いた抗IL-6Rアプタマーの開発2022

    • Author(s)
      笠原勇矢、千賀陽子、石田健太、奥田匠、長尾知生子、新山真由美、鎌田春彦、水口賢司、小比賀聡
    • Organizer
      日本核酸医薬学会第7回年会
    • Data Source
      KAKENHI-PROJECT-21K12125
  • [Presentation] 胃がん腹膜播種治療に向けたSYT13標的アンチセンス核酸の毒性評価およびオフターゲット解析2021

    • Author(s)
      笠原勇矢, 神田光郎, 山隈晴美, 亀岡なつ実, 小比賀聡
    • Organizer
      日本核酸医薬学会第6回年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] 人工核酸アプタマーを利用したMCM8-9阻害剤の開発2021

    • Author(s)
      内堀友紀, 笠原勇矢, 真柳浩太, 杉本のぞみ, 藤田雅俊
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • [Presentation] Development of xeno nucleic acid aptamers targeting the SARS-CoV-2 spike protein for COVID-19 therapeutics2021

    • Author(s)
      石田健太, 笠原勇矢, 星野秀和, 小比賀聡
    • Organizer
      日本核酸医薬学会第6回年会
    • Data Source
      KAKENHI-PROJECT-21K14743
  • 1.  KANDA Mitsuro (00644668)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  小比賀 聡 (80243252)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  清水 大 (50723037)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  田中 千恵 (50589786)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  Nagao Chioko (10402463)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  榎本 平之 (40449880)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  西川 浩樹 (30769609)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  小寺 泰弘 (10345879)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  李 秀栄 (50390670)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  飯島 尋子 (80289066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  中西 香企 (10836183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  新崎 信一郎 (60546860)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  由利 幸久 (90992933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  大澤 昂志 (00783226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  桑原 正靖 (40334130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  細田 忠弘 (31017734)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  山口 朋子 (50580130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  原 知明 (30779161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  石井 秀始 (10280736)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  孟 思昆 (50977204)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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