Kuwahara Masayasu 桑原正靖

… Alternative Names

KUWAHARA Masayasu 桑原正靖

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Researcher Number	40334130
Other IDs
External Links
Affiliation (Current)	2026: 日本大学, 文理学部, 教授
Affiliation (based on the past Project Information) *help	2025: 日本大学, 文理学部, 教授 2018 – 2023: 日本大学, 文理学部, 教授 2014 – 2017: 群馬大学, 大学院理工学府, 准教授 2013: 群馬大学, 理工学研究科, 准教授 2012: 群馬大学, 工学(系)研究科(研究院), 准教授 … More 2009 – 2012: Gunma University, 大学院・工学研究科, 准教授 2009 – 2010: 群馬大学, 工学研究科, 准教授 2008: 群馬大学, 工学研究科, 助教 2007 – 2008: Gunma University, 大学院・工学研究科, 助教 2002 – 2006: 群馬大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 37030:Chemical biology-related / Science and Engineering / Living organism molecular science / Biomolecular chemistry / Bioorganic chemistry Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Endocrinology / Science and Engineering / Experimental pathology / Biofunction/Bioprocess
Keywords	Principal Investigator 有機化学 / 生体生命情報学 / バイオテクノロジー / 核酸 / Point of Care Testing / グアニン四重鎖 / 等温遺伝子増幅法 / イメージング / バイオマーカー / miRNA … More / 薬剤耐性ウイルス / 簡易遺伝子変異検出 / 逆転写PCR法 / 等温核酸増幅法 / RNAウイルス / 環境応答性 / 刺激応答性 / スイッチ分子 / 核酸アプタマー / キセノ核酸 / ゲノム … More Except Principal Investigator アプタマー / PCR / BBBモデル / 人工核酸 / アンチセンス核酸 / 心脳血管障害誘発因子 / モデル動物 / アルドステロン産生腫瘍 / 副腎 / ＫＣＮＪ５ / KCNJ5変異 / 腫瘍発生 / 高血圧症 / 原発性アルドステロン症 / Aptamer / Molecular Recognition / Enzymatic Reaction / Modified Substrate / DNA polymerase / Modified DNA / Nucleic Acid / 試験管内選択 / DNA触媒 / DNAアプタマー / 機能性DNA / 糖鎖 / 生体機能利用 / DNA / 分子認識 / 酵素反応 / 修飾基質 / DNAポリメラーゼ / 修飾DNA / 核酸 / 肝臓 / PPAR / モデルマウス / PPARα / HNF4α / 核内受容体 / 脂肪肝 / プローブ / 質量分析 / ナノLC / ゼブラフィッシュ / miRNA / RNA / MS / LC / メタボロミクス Less

Development of functional nucleic acid molecules using a blood-brain barrier model
- Principal Investigator
  
  笠原勇矢
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Development of intracellular microRNA imaging technology using SATIC methodPrincipal Investigator
- Principal Investigator
  
  KUWAHARA Masayasu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nihon University
Development of a simple gene mutation detection method and verification of the frequency of drug-resistant virusesPrincipal Investigator
- Principal Investigator
  
  KUWAHARA Masayasu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nihon University
Insight into mechanisims undelying Primary aldosteronism
- Principal Investigator
  
  Masanobu Yamada
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  Gunma University
Creation of xenonucleic acid switch moleculesPrincipal Investigator
- Principal Investigator
  
  Kuwahara Masayasu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Gunma University
Study of the nuclear receptors involved in fatty livers; establishment of a new pathological model and development of therapeutic application.
- Principal Investigator
  
  INOUE Yusuke
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Gunma University
Design and creation of condition-responsive nano-drug-carriers involving by the step-wise construction method using intelligent nucleic acidsPrincipal Investigator
- Principal Investigator
  
  KUWAHARA Masayasu
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Gunma University
Development of fundamental technology for accurate RNAomics
- Principal Investigator
  
  FUKUSAKI Eiichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Osaka University
1分子シーケンスに資する化学修飾DNA断片および核酸基質アナログの創製Principal Investigator
- Principal Investigator
  
  桑原正靖
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Gunma University
1分子シーケンシングに適したDNA断片の簡便な調製法の開発Principal Investigator
- Principal Investigator
  
  桑原正靖
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Gunma University
多重修飾DNAライブラリを用いた応用インビトロ・セレクション法の開発Principal Investigator
- Principal Investigator
  
  桑原正靖
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Gunma University
一塩基多型(SNPs)検出のための修飾DNAアプタマーの創製Principal Investigator
- Principal Investigator
  
  桑原正靖
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
一塩基多型(SNPs)検出のための修飾DNAアプタマーの創製Principal Investigator
- Principal Investigator
  
  桑原正靖
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
一塩基多型(SNPs)検出のための修飾DNAアプタマーの創製Principal Investigator
- Principal Investigator
  
  桑原正靖
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
コンビナトリアル的手法を用いた修飾デオキシリボザイムの創製Principal Investigator
- Principal Investigator
  
  桑原正靖
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Gunma University
Enzymatic Synthesis of Modified DNAs by PCR, and Their Application
- Principal Investigator
  
  SAWAI Hiroaki
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Gunma University

[Book] Detection systems using the ternary complex formation of nucleic acids (Handbook of chemical biology of nucleic acids)2022
- Author(s)
  Hiroto Fujita, Masayasu Kuwahara
- Total Pages
  18
- Publisher
  Springer, Singapore
- ISBN
  9789811613135
- Data Source
  KAKENHI-PROJECT-21K05317
[Book] 核酸科学ハンドブック（23章を担当）2020
- Author(s)
  杉本直己，鳥越秀峰，片平正人，桑原正靖ほか
- Publisher
  講談社
- ISBN
  9784065207864
- Data Source
  KAKENHI-PROJECT-18K05347
[Book] RNA Technologies (Chemical Biology of Nucleic Acids); Progress in Chemically Modified Nucleic Acid Aptamers2014
- Author(s)
  M. Kuwahara
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25350962
[Book] 「人工核酸を用いたポリメラーゼ反応と人工核酸アプタマーの創製」生化学82巻4号2010
- Author(s)
  桑原正靖
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-21710221
[Book] 生化学,82巻4号(人工核酸を用いたポリメラーゼ反応と人工核酸アプタマーの創製)2010
- Author(s)
  桑原正靖
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-21710221
[Book] 月刊化学四月号(核酸アプタマーのケミカル・ルネサンス)2009
- Author(s)
  桑原正靖, 杉本直己
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-21710221
[Book] 「核酸アプタマーのケミカル・ルネサンス」月刊化学四月号2009
- Author(s)
  桑原正靖, 杉本直己
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-21710221
[Book] ゲノムケミストリー/第4章2節「人工修飾核酸を用いた試験管内選択法(セレックス法)の拡張」(関根光雄・齋藤烈編)2003
- Author(s)
  澤井宏明, 桑原正靖
- Total Pages
  240
- Publisher
  講談社
- Data Source
  KAKENHI-PROJECT-14780456
[Journal Article] Lantern-type G-quadruplex fluorescent sensors for detecting divalent metal ions2024
- Author(s)
  Wariishi Tomoko、Kataoka Yuka、Nakamura Tomoaki、Kasahara Yuuya、Kuroda Masataka、Obika Satoshi、Kuwahara Masayasu
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 690 Pages: 115525-115525
- DOI
  10.1016/j.ab.2024.115525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05317
[Journal Article] Field-effect transistor biosensor with signal amplification by ternary initiation complexes for detection of wide-range RNA concentration2024
- Author(s)
  Hayashi Hiroki、Enami Akihiro、Fujita Hiroto、Kuroiwa Shigeki、Ohashi Keishi、Kuwahara Masayasu、Osaka Tetsuya、Momma Toshiyuki
- Journal Title
  
  Talanta
  
  Volume: 273 Pages: 125846-125846
- DOI
  10.1016/j.talanta.2024.125846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13644, KAKENHI-PROJECT-21K05317
[Journal Article] Effects of Modifying Thioflavin T at the N3-Position on Its G4 Binding and Fluorescence Emission2020
- Author(s)
  Y. Kataoka, H. Fujita, T. Endoh, N. Sugimoto, and M. Kuwahara
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 21 Pages: 4936-4936
- DOI
  10.3390/molecules25214936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05723, KAKENHI-PROJECT-19H00928, KAKENHI-PROJECT-18K05347
[Journal Article] High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives2018
- Author(s)
  Kataoka Yuka、Fujita Hiroto、Afanaseva Arina、Nagao Chioko、Mizuguchi Kenji、Kasahara Yuuya、Obika Satoshi、Kuwahara Masayasu
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 6 Pages: 493-498
- DOI
  10.1021/acs.biochem.8b01181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11775, KAKENHI-PROJECT-18K05347
[Journal Article] In vitro selection of DNA-based aptamers that exhibit RNA-like conformations using a chimeric oligonucleotide library that contains two different xeno-nucleic acids.2015
- Author(s)
  Hagiwara K, Fujita H, Kasahara Y, Irisawa Y, Obika S, Kuwahara M.
- Journal Title
  
  Mol Biosyst.
  
  Volume: 11(1) Issue: 1 Pages: 71-76
- DOI
  10.1039/c4mb00436a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25350962
[Journal Article] Polymerase-mediated high-density incorporation of amphiphilic functionalities into DNA: enhancement of nuclease resistance and stability in human serum.2015
- Author(s)
  Fujita H, Nakajima K, Kasahara Y, Ozaki H, Kuwahara M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 25(2) Pages: 333-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25350962
[Journal Article] Modified nucleic acid aptamer selections using capillary electrophoresis2015
- Author(s)
  桑原正靖、萩原健太、入澤祐太、笠原勇矢
- Journal Title
  
  Electrophoresis Letters
  
  Volume: 59 Issue: 2 Pages: 88-90
- DOI
  10.2198/electroph.59.88
- NAID
  130005103929
- ISSN
  2189-2628, 2189-2636
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350962
[Journal Article] Minimal thioflavin T modifications improve visual discrimination of guanine-quadruplex topologies and alter compound-induced topological structures.2014
- Author(s)
  Kataoka Y, Fujita H, Kasahara Y, Yoshihara T, Tobita S, Kuwahara M.
- Journal Title
  
  Anal Chem.
  
  Volume: 86(24) Issue: 24 Pages: 12078-84
- DOI
  10.1021/ac5028325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350962, KAKENHI-PLANNED-26111012
[Journal Article] Structural and Affinity Analyses of G-Quadruplex DNA Aptamers for Camptothecin Derivatives2013
- Author(s)
  Hiroto Fujita, Yuri Imaizumi, Yuuya Kasahara, et al.
- Journal Title
  
  Pharmaceuticals (Basel)
  
  Volume: 6 Issue: 9 Pages: 1082-1093
- DOI
  10.3390/ph6091082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10396, KAKENHI-PROJECT-24245033, KAKENHI-PROJECT-25350962
[Journal Article] In vitro selection of BNA (LNA) aptamers.2013
- Author(s)
  Kuwahara M, Obika S.
- Journal Title
  
  Artif DNA PNA XNA.
  
  Volume: 4(2) Issue: 2 Pages: 39-48
- DOI
  10.4161/adna.25786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350962
[Journal Article] Efficacy of base-modification on target binding of small molecule DNA aptamers2013
- Author(s)
  Yuri Imaizumi, Yuuya Kasahara, et al.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 135 Issue: 25 Pages: 9412-9419
- DOI
  10.1021/ja4012222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10396, KAKENHI-PROJECT-24245033, KAKENHI-PROJECT-24655161, KAKENHI-PROJECT-25350962
[Journal Article] CE-SELEX Selection of Base- and Sugar-modified DNA Aptamers : Target Binding Dominated by 2', 4'-BNA/LNA Primer2013
- Author(s)
  Yuuya Kasahara, et al.
- Journal Title
  
  Analytical Chemistry
  
  Volume: 85(10) Issue: 10 Pages: 4961-4967
- DOI
  10.1021/ac400058z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10396, KAKENHI-PROJECT-25350962
[Journal Article] Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3'-overhang regions and its RNAi activity2011
- Author(s)
  Masud MM, Masuda T, Inoue Y, Kuwahara M, Sawai H, and and Ozaki H.
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 21 Issue: 2 Pages: 715-717
- DOI
  10.1016/j.bmcl.2010.11.125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590354
[Journal Article] Study on suitability of KOD DNA polymerase for enzymatic production of artificial nucleic acids using base/sugar modified nucleoside triphosphates.2010
- Author(s)
  Kuwahara M, Takano Y, Kasahara Y, Nara H, Ozaki H, Sawai H, Sugiyama A, Obika S.
- Journal Title
  
  Molecules
  
  Volume: 15 Pages: 8229-8240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Effect of 3'-end capping of aptamer with various 2',4'-bridged nucleotides : enzymatic post-modification toward a practical use of polyclonal aptamers.2010
- Author(s)
  Yuya Kasahara, Syunsuke Kitadume, Masayasu Kuwahara, Hiroaki Ozaki, Hiroaki Sawai, Kunihiko Morihiro, Takashi Imanishi, Satoshi Obika.
- Journal Title
  
  Bioorg.Med.Chem.Lett. 20
  
  Pages: 1626-1629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Study on suitability of KOD DNA polymerase for enzymatic production of artificial nucleic acids using base/sugar modified nucleoside triphosphates.2010
- Author(s)
  Masayasu Kuwahara, Yuki Takano, Yuya Kasahara, Hiroki Nara, Hiroaki Ozaki, Hiroaki Sawai, Akio Sugiyama, Satoshi Obika.
- Journal Title
  
  Molecules 15
  
  Pages: 8229-8240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Effect of 3'-end capping of aptamer with various 2', 4'-bridged nucleotides : enzymatic post-modification toward a practical use of polyclonal aptamers2010
- Author(s)
  Y.Kasahara, S.Kitadume, M.Kuwahara, H.Ozaki, H.Sawai, K.Morihiro, T.Imanishi, S.Obika
- Journal Title
  
  Bioorg.Med.Chem.Lett. 20
  
  Pages: 1626-1629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Molecular evolution of functional nucleic acids with chemical modifications.2010
- Author(s)
  Masayasu Kuwahara, Naoki Sugimoto.
- Journal Title
  
  Molecules 15
  
  Pages: 5423-5444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Molecular evolution of functional nucleic acids with chemical modifications.2010
- Author(s)
  Kuwahara M, Sugimoto N.
- Journal Title
  
  Molecules
  
  Volume: 15 Pages: 5423-5444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Study on suitability of KOD DNA polymerase for enzymatic production of artificial nucleic acids using base/sugar modified nucleoside trip hosphates.2010
- Author(s)
  Masayasu Kuwahara, Yuki Takano, Yuya Kasahara, Hiroki Nara, Hiroaki Ozaki, Hiroaki Sawai, Akio Sugiyama, Satoshi Obika
- Journal Title
  
  Molecules
  
  Volume: 15(11) Pages: 8229-8240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20360374
[Journal Article] Studyon suitability of KOD DNA polymerase forenzymatic production of artificial nucleic acids using base/sugar modified nucleoside triphosphates2010
- Author(s)
  Masayasu Kuwahara, Yuki Takano, Yuya Kasahara, Hiroki Nara, Hiroaki Ozaki, Hiroaki Sawai, Akio Sugiyama, Satoshi Obik
- Journal Title
  
  Molecules 15(11)
  
  Pages: 8229-8240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20360374
[Journal Article] Fluorescent properties of acridonyl group in DNA duplex.2009
- Author(s)
  Masayasu Kuwahara, Atsushi Kobayashi, Masayoshi Tajima, Shunsuke Kitazume, Keisuke Anahara, Hiroaki Oazaki, Seiji Tobita.
- Journal Title
  
  Nucleic Acids Symp.Ser.(Oxford University Press) 53
  
  Pages: 137-138
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Smart conferring of nuclease resistance to DNA by 3'-end protection using 2', 4'-bridged nucleoside-5'-triphosphates2009
- Author(s)
  M.Kuwahara, S.Obika, H.Takeshima, Y.Hagiwara, J.Nagashima, H.Ozaki, H.Sawai, T.Imanishi
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 2941-2943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Fluorescent properties of acridonyl group in DNA duplex2009
- Author(s)
  M.Kuwahara, A.Kobayashi, M.Tajima, S.Kitazume, K.Anahara, H.Oazaki, S.Tobita
- Journal Title
  
  Nucleic Acids Symp.Ser.(Oxford University Press) 53
  
  Pages: 137-138
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Smart conferring of nuclease resistance to DNA by 3'-end protection using 2',4'-bridged nucleoside-5'- triphosphates.2009
- Author(s)
  Masayasu Kuwahara, Satoshi Obika, Hidetoshi Takeshima, Yoshihiko Hagiwara, Junichi Nagashima, Hiroaki Ozaki, Hiroaki Sawai, Takeshi Imanishi
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 2941-2943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Transcription and reverse transcription of artificial nucleic acids involving backbone modification bytemplate-directed DNA polymerase reactions2009
- Author(s)
  Kuwahara, H., Takeshima, J., Nagashima,S., Minezaki, H., Ozaki, H., Sawai
- Journal Title
  
  Bioorg. Med. Chem 17
  
  Pages: 3772-3788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20360374
[Journal Article] Transcription and reverse transcription of artificial nucleic acids involving backbone modification by template-directed DNA polymerase reactions2009
- Author(s)
  M.Kuwahara, H.Takeshima, J.Nagashima, S.Minezaki, H.Ozaki, H.Sawai
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 3782-3788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Transcription and reverse transcription of artificial nucleic acids involving backbone modification by template-directed DNA polymerase reactions.2009
- Author(s)
  Masayasu Kuwahara, Hidetoshi Takeshima, Junichi Nagashima, Satoshi Minezaki, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 3782-3788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710221
[Journal Article] Transcription and reverse transcription of artificial nucleic acids involving backbone modification by template-directed DNA polymerase reactions2009
- Author(s)
  M.Kuwahara, H.Takeshima, J.Nagashima, S.Minezaki, H.Ozaki, H.Sawai
- Journal Title
  
  Bioorg. Med. Chem. 17
  
  Pages: 3782-3788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20360374
[Journal Article] Effect of backbone-modification of oligodeoxyribonucleic acid on primer extension reactions2008
- Author(s)
  M. Kuwahara, S. Minezaki, J. Nagashima. H. Ozaki. h. Sawai.
- Journal Title
  
  Nucleic Acids Symp. Ser. 52
  
  Pages: 453-454
- Data Source
  KAKENHI-PROJECT-19021008
[Journal Article] Arginine-modified DNA Aptamers That Show Enantioselective Recognition of the Dicarboxylic Acid Moiety of Glutamic Acid2008
- Author(s)
  Kazuomi Ohsawa, Toshiyuki Kasamatsu, Jun-ichi Nagashima, Kazuo Hanawa, Masayasu Kuwahara, Hiroaki Ozaki and Hiroaki Sawai
- Journal Title
  
  Analytical Sciences 24,(1)
  
  Pages: 167-172
- NAID
  10020143849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17710179
[Journal Article] Systematic analysis of enzymatic DNApolymerization using oligo-DNA templates andtriphosphate analogs involving 2',4'-bridgednucleosides.2008
- Author(s)
  M., Kuwahara, S., Obika, J., Nagashima
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 4257-4265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20360374
[Journal Article] Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2',4'-bridged nucleosides2008
- Author(s)
  M. Kuwahara, S. Obika, J. Nagashima, Y. Ohta, Y. Suto, H. Ozaki, H. Sawai, and T. Imanishi
- Journal Title
  
  Nucleic Acids Res. 36, (13)
  
  Pages: 4257-4265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021008
[Journal Article] Arginine-modified DNA Aptamers That Show Enantioselective Recognition of the Dicarboxylic Acid Moiety of Glutamic Acid2008
- Author(s)
  Kazuomi Ohsawa, Toshiyuki Kasamatsu, Jun-ichi Nagashima, Kazuo Hanawa, Masayasu Kuwahara, Hiroaki Ozaki and Hiroaki Sawai
- Journal Title
  
  Analytical Sciences 24,(1)
  
  Pages: 167-172
- NAID
  10020143849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021008
[Journal Article] Acridone-tagged DNA as a new probe for DNA detection by fluorescence resonarce energy transfer and for mismatch DNA recognition2008
- Author(s)
  Y. Hagiwara, T. Hasegawa, A. Shoji, M Kuwahara Ozaki H. and Sawai
- Journal Title
  
  Bioorg. Med. Chem. 16, (14)
  
  Pages: 7013-7020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021008
[Journal Article] Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2', 4'-bridged nucleosides.2008
- Author(s)
  M. Kuwahara S. Obika J. Nagashima
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 42574265-42574265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20360374
[Journal Article] A modified DNA aptamer that binds the(R)-isomer of a thalidomide derivative with high enantioselectivity.2007
- Author(s)
  Atsushi Shoji, Masayasu Kuwahara, Hiroaki Ozaki and Hiroaki Sawai
- Journal Title
  
  Journal of the American Chemical Society 129,(5)
  
  Pages: 1456-1464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17710179
[Journal Article] Polymerisation of a DNA strand using oligo-DNA template with modified bases, sugars and phosphates2007
- Author(s)
  Jun-ichi Nagashima, Satoshi Minezaki, Satoshi Obika, Takeshi Imanishi, Masayasu Kuwahara and Hiroaki Sawai
- Journal Title
  
  Nucleic Acids Symposium Series 51
  
  Pages: 55-56
- Data Source
  KAKENHI-PROJECT-17710179
[Journal Article] Differences in substrate specificity of C(5)-substituted or C(5)-unsubstituted pyrimidinenucleotides by DNA polymerases from thermophilic bacteria, archaea, and phages2007
- Author(s)
  Hiroaki Sawai, Jun-ichi Nagashima, Masayasu Kuwahara, Rina Kitagata, Takehiro Tamura, Ikuo Matsui
- Journal Title
  
  Chemistry & Biodiversity 4,(9)
  
  Pages: 1979-1995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17710179
[Journal Article] Polymerisation of a DNA strand using oligo-DNA template with modified bases, sugars and phosphates2007
- Author(s)
  Jun-ichi Nagashima, Satoshi Minezaki, Satoshi Obika, Takeshi Imanishi, Masayasu Kuwahara and Hiroaki Sawai
- Journal Title
  
  Nucleic Acids Symposium Series 51
  
  Pages: 55-56
- Data Source
  KAKENHI-PROJECT-19021008
[Journal Article] A modified DNA aptamer that binds the (R)-isomer of a thalidomide derivative with high enantioselectivity.2007
- Author(s)
  Atsushi Shoji, Masayasu Kuwahara, Hiroaki Ozaki and Hiroaki Sawai
- Journal Title
  
  Journal of the American Chemical Society 129,(5)
  
  Pages: 1456-1464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021008
[Journal Article] Chemico-enzymatic synthesis of a new fluorescent-labeled DNA by PCR with a thymidine nucleotide analogue bearing an acridone derivative2007
- Author(s)
  Atsudhi Shoji, Hasegawa Tomoya, Masayasu Kuwahara, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Bioorg.Med.Chem.Lett. 17(3)
  
  Pages: 776-779
- Data Source
  KAKENHI-PROJECT-18038004
[Journal Article] Direct PCR amplification of various modified DNAs having amino acids found in proteins : convenient preparation of DNA libraries with high-potential activities for in vitro selection.2006
- Author(s)
  Masayasu Kuwahara, Kazuo Hanawa, Kazuomi Ohsawa, Rina Kitagata, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Bioorganic & Medicinal Chemistry 14,(8)
  
  Pages: 2518-2526
- Data Source
  KAKENHI-PROJECT-17710179
[Journal Article] Synthesis and property of DNA labeled with fluorescent acridone2006
- Author(s)
  Hasegawa Tomoya, Atsudhi Shoji, Masayasu Kuwahara, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Nucleic Acids Symp.Ser. 50
  
  Pages: 145-146
- Data Source
  KAKENHI-PROJECT-18038004
[Journal Article] Substrate property and incorporation accuracy of various dATP analogs during enzymatic polymerization using thermostable DNA polymerases2006
- Author(s)
  Masayasu Kuwahara, Yosshiyuki Suto, Satoshi Minezaki, Rina Kitagata, Jun-ichi Nagashima, Hiroaki Sawai
- Journal Title
  
  Nucleic Acids Symp.Ser. 50
  
  Pages: 31-32
- Data Source
  KAKENHI-PROJECT-17710179
[Journal Article] Screening of modified DNA aptamers that recognize DNA secondary structure2004
- Author(s)
  M Kuwahara et al.
- Journal Title
  
  Nucleic Acids Symp. Ser. 48
  
  Pages: 265-266
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Sialllyllactose-binding modified DNa aptamer bearing additional functionality by SELEX2004
- Author(s)
  M.M.Masud, M, M.Kuwahara, H.Ozaki, H.Sawai
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 1111-1120
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] 5位置換ピリミヂンヌクレオシドを含むオリゴヌクレオチドの合成とその性質2004
- Author(s)
  尾崎宏明, 桑原正靖, 澤井宏明
- Journal Title
  
  有機合成化学協会誌 62
  
  Pages: 1238-1248
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Detection of biomolecule by aotamer beacon2004
- Author(s)
  A.Nishihira, H.Ozaki, M.Wakabayashiu, M.Kuwahara, H.Sawai
- Journal Title
  
  Nucleic Acids Symp.Ser. 48
  
  Pages: 135-136
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Screening of modified DNA aptamers that recognize DNA secondary structure2004
- Author(s)
  M.Kuwahara et al.
- Journal Title
  
  Nucleic Acids Symp. Ser. 48
  
  Pages: 265-266
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] 5位置換ピリミジンヌクレオシドを含むオリゴヌクレオチドの合成とその性質2004
- Author(s)
  尾崎広明, 桑原正靖澤井宏明
- Journal Title
  
  有機合成化学協会誌 62(12)
  
  Pages: 1238-1248
- NAID
  10014119789
- Data Source
  KAKENHI-PROJECT-16011206
[Journal Article] Screening of modified DNA aptamers that recognize DNA secondary structure2004
- Author(s)
  Masayasu Kuwahara, Toshiyuki Kasamatsu, Masatoshi Hasegawa, Atsushi Shoji, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Nucleic Acids Res.Sym.Ser. 48
  
  Pages: 265-266
- Data Source
  KAKENHI-PROJECT-14780456
[Journal Article] Screening of modified DNA aptamers that recognize DNA secondary structure2004
- Author(s)
  M.Kuwahara, T.Kasamatsu, M.Hasgawa, A.Shoji, H.Ozaki, H.Sawai
- Journal Title
  
  Nucleic Acids Symp.Ser. 48
  
  Pages: 265-266
- Data Source
  KAKENHI-PROJECT-13132202
[Journal Article] Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX2004
- Author(s)
  Masud M.Mohammad, Masayasu Kuwahara, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Bioorganic & Medicinal Chemistry 12(5)
  
  Pages: 1111-1120
- Data Source
  KAKENHI-PROJECT-16011206
[Journal Article] Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX2004
- Author(s)
  Masud M.Mohammad, Masayasu Kuwahara, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Bioorganic & Medicinal Chemistry 12(5)
  
  Pages: 1111-1120
- Data Source
  KAKENHI-PROJECT-14780456
[Journal Article] Screening of modified DNA aptamers that recognize DNA secondary structure2004
- Author(s)
  Masayasu Kuwahara, Toshiyuki Kasamatsu, Masatoshi Hasegawa, Atsushi Shoji, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Nucleic Acids Res.Sym.Ser. 48
  
  Pages: 265-266
- Data Source
  KAKENHI-PROJECT-16011206
[Journal Article] Simultaneous incorporation of three different modified nucleotides during PCR2003
- Author(s)
  Masayasu Kuwahara, Shin-ichi Hososhima, Yumi Takahata, Rina Kitagata, Atsushi Shoji, Kazuo Hanawa, Akiko N.Ozaki, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Nucleic Acids Res.Suppl. 3
  
  Pages: 37-38
- Data Source
  KAKENHI-PROJECT-14780456
[Journal Article] Modified DNA Bearing 5-(Methoxycarbonylmethyl)-2'-deoxyuridine : Preparation by PCR with Thermophilic DNA Polymerase and Post Synthetic Derivatization2003
- Author(s)
  Mohammad M.Masud, Akiko N.Ozaki, Masayasu Kuwahara, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  ChemBioChem 4
  
  Pages: 584-588
- Data Source
  KAKENHI-PROJECT-14780456
[Journal Article] Creation of functionally modified nucleic acid derivatives by in vitro selection method2003
- Author(s)
  Masayasu Kuwahara, Hiroaki Sawai
- Journal Title
  
  Expected Materials for the Future 3(9)
  
  Pages: 51-57
- Data Source
  KAKENHI-PROJECT-14780456
[Journal Article] Substrate Properties of C5-Substituted Pyrimidine 2'-Deoxynucleoside 5'-Triphosphates for Thermostable DNA Polymerases during PCR2003
- Author(s)
  Masayasu Kuwahara, Yumi Takahata, Atsushi Shoji, Akiko N.Ozaki, Hiroaki Ozaki, Hiroaki Sawai
- Journal Title
  
  Bioorg.Med.Chem.Lett. 13(21)
  
  Pages: 3735-3738
- Data Source
  KAKENHI-PROJECT-14780456
[Patent] 磁気ビーズ撹拌機構を備えた核酸増幅反応用装置2020
- Inventor(s)
  桑原正靖, 藤田博仁
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-122057
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K05347
[Patent] 核酸増幅反応用多層化プレミクス試薬およびReady to use核酸増幅反応キット2020
- Inventor(s)
  桑原正靖, 藤田博仁
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-102479
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K05347
[Patent] 新型コロナウイルスＳＡＲＳ－ＣｏＶ－２の検出キットおよび検出方法2020
- Inventor(s)
  河島尚志, 桑原正靖, 藤田博仁
- Industrial Property Rights Holder
  東京医科大学，日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-083024
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K05347
[Patent] 核酸配列等の簡易検出法2019
- Inventor(s)
  桑原正靖，藤田博仁
- Industrial Property Rights Holder
  日本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-217075
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K05347
[Patent] 新規ヌクレオシド誘導体、それを含むポリヌクレオチド及びそれを用いた塩基の識別方法2009
- Inventor(s)
  桑原正靖・尾崎広明
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2009-072157
- Filing Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-19021008
[Patent] 新規ヌクレオシド誘導体、それを含むポリヌクレオチド及びそれを用いた塩基の識別方法2009
- Inventor(s)
  桑原正靖、尾崎広明
- Industrial Property Rights Holder
  群馬大学
- Filing Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-20360374
[Patent] 新規核酸誘導体及びそれを用いたポリヌクレオチドの製造方法2005
- Inventor(s)
  桑原正靖, 澤井宏明
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-217479
- Filing Date
  2005-07-27
- Data Source
  KAKENHI-PROJECT-17710179
[Patent] C5位置換ピリミジン又は6位置換プリン-2'-デオキシヌクレオチド誘導体、及びそれを用いた核酸の合成方法2003
- Inventor(s)
  澤井宏明, 桑原正靖
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2003-207194
- Filing Date
  2003-08-18
- Data Source
  KAKENHI-PROJECT-14780456
[Presentation] Ab initio DNA合成における効率的増幅の検討2024
- Author(s)
  片岡由佳，久保千尋，割石智子，藤田博仁，桑原正靖
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] チオフラビンT誘導体／グアニン四重鎖複合体の多価金属イオンに対する蛍光特性評価2024
- Author(s)
  割石智子，片岡由佳，藤田博仁，笠原勇矢，小比賀聡，桑原正靖
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] グアニン四重鎖／チオフラビンT誘導体の複合体形成におけるグアニジノ基の導入効果2024
- Author(s)
  白鳥悠香，中村友昭，割石智子，片岡由佳，桑原正靖
- Organizer
  日本化学会第104春季年会
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] 等温核酸増幅反応における増幅子の同定と性能評価2023
- Author(s)
  久保千尋，藤田博仁，桑原正靖
- Organizer
  日本化学会第103春季年会 (2023)
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] Forster共鳴エネルギー移動によるチオフラビンT発光の長波長化の検討2023
- Author(s)
  中村友昭，熊谷俊輔，割石智子，片岡由佳，桑原正靖
- Organizer
  日本化学会第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] チオフラビンT誘導体を用いた2価金属イオンの検出2023
- Author(s)
  割石智子，片岡由佳，藤田博仁，笠原勇矢，小比賀聡，桑原正靖
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] Investigation of important factor for efficient amplification by ab initio DNA synthesis2023
- Author(s)
  Yuka Kataoka, Chihiro Kubo, Tomoko Wariishi, Hiroto Fujita, Masayasu Kuwahara
- Organizer
  The 50th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] Detection systems that start with the ternary initiation complex formation2022
- Author(s)
  Masayasu Kuwahara
- Organizer
  FIBER International Summit for Nucleic Acids 2022 (FISNA2022)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] 新規バイオマーカー検出法（SATIC 法）の開発と今後2021
- Author(s)
  桑原正靖
- Organizer
  第94回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] 等温遺伝子増幅法におけるマルチプレックス検出に向けたグアニン四重鎖結合性蛍光色素の検討2021
- Author(s)
  藤田博仁，田村美雪，桑原正靖
- Organizer
  日本化学会第102春季年会 (2022)
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] マラカイトグリーン結合性DNAアプタマーのセレクションおよび蛍光特性評価2021
- Author(s)
  田村美雪，藤田博仁，桑原正靖
- Organizer
  日本化学会第102春季年会 (2022)
- Data Source
  KAKENHI-PROJECT-21K05317
[Presentation] PCR法に代わる革新的核酸増幅法を用いた唾液からのCOVID-19の目視による迅速診断法の開発2020
- Author(s)
  桑原正靖
- Organizer
  バイオインダストリー協会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] SATIC法の原理とCOVID-19簡易検査への応用2020
- Author(s)
  桑原正靖
- Organizer
  第5回Liquid Biopsy研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] Method for high sensitive detection of various biomarkers2019
- Author(s)
  Kuwahara M
- Organizer
  Asian 3 Roundtable on Nucleic Acids 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] Ultra-high sensitive simple test methods for various biomarkers2019
- Author(s)
  Kuwahara M
- Organizer
  Advances in Noncanonical Nucleic Acids 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] Development of unique nucleic acid materials for diagnosis and therapeutics2019
- Author(s)
  Kuwahara M
- Organizer
  Poland-Japan RNA Meeting, Poznan 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] Fluorescence Molecular Rotors Thioflavin T Derivatives for Various Targets2018
- Author(s)
  Masayasu Kuwahara
- Organizer
  The 2nd International Symposium on Functional Nucleic Acids (FNA2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] Thioflavin T derivatization: Creation of fluorescence indicators for various targets2018
- Author(s)
  Masayasu Kuwahara
- Organizer
  Advances in Noncanonical Nucleic Acids 2018 (ANNA2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] Development of unique nucleic acid materials for diagnosis and therapeutics2018
- Author(s)
  Masayasu Kuwahara
- Organizer
  NanoTech Poland 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] Target-Directing Fluorescent Molecular Rotors2018
- Author(s)
  Masayasu Kuwahara
- Organizer
  Asian 3 Roundtable on Nucleic Acids (A3RONA)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05347
[Presentation] 医薬・診断薬創製に向けた化学修飾核酸アプタマーのセレクション法開発2015
- Author(s)
  桑原正靖
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] 薬物伝達法への応用に向けた人工核酸アプタマーの開発2015
- Author(s)
  桑原正靖
- Organizer
  第31回日本DDS学会学術集会・ワークショップ4・核酸医薬開発の鍵を握るデリバリー技術の新展開
- Place of Presentation
  東京・京王プラザホテル
- Year and Date
  2015-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Syntheses and properties of novel Thioflavin T analogs2015
- Author(s)
  Masayasu Kuwahara
- Organizer
  Asia 3 Roundtable on Nucleic Acids 2015
- Place of Presentation
  Suwon, Korea
- Year and Date
  2015-09-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] キャピラリー電気泳動法を用いた修飾核酸アプタマーのセレクション2015
- Author(s)
  桑原正靖
- Organizer
  第66回日本電気泳動学会総会
- Place of Presentation
  東京・東京工科大学蒲田キャンパス
- Year and Date
  2015-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Application of unnatural nucleicacids and non-canonical nucleic acid structures towards drug discovery and bioanalysis2015
- Author(s)
  Masayasu Kuwahara
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] キャピラリー電気泳動セレクション法による血管内皮細胞増殖因子結合性塩基修飾DNAアプタマーのセレクション2015
- Author(s)
  本田直渡，笠原勇矢，萩原健太，桑原正靖
- Organizer
  日本化学会第94春季年会(2015)
- Place of Presentation
  日本大学理工学部船橋キャンパス/薬学部
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Xeno-nucleic acid aptamers2015
- Author(s)
  Masayasu Kuwahara
- Organizer
  The 1st International Symposium on “Functional Nucleic Acids: From Laboratory to Targeted Molecular Therapy”
- Place of Presentation
  Perth, Australia
- Year and Date
  2015-11-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Thioflavin T analogs as G-quadruplex indicators and their applications to bioanalysis2015
- Author(s)
  Yuka Kataoka，Hiroto Fujita，Masayasu Kuwahara
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] オリゴヌクレオチドの鎖長がキャピラリー・ゾーン電気泳動法による標的/核酸アプタマー複合体の分離能に及ぼす影響2015
- Author(s)
  萩原健太，本田直渡，笠原勇矢，桑原正靖
- Organizer
  日本化学会第94春季年会(2015)
- Place of Presentation
  日本大学理工学部船橋キャンパス/薬学部
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] 架橋型ヌクレオチドからなるキセノ核酸の酵素的合成2015
- Author(s)
  笠井達郎，片岡由佳，藤田博仁，本田直渡，笠原勇矢，小比賀聡，桑原正靖
- Organizer
  日本化学会第94春季年会(2015)
- Place of Presentation
  日本大学理工学部船橋キャンパス/薬学部
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] RNA detection method using a thioflavin-T analog2015
- Author(s)
  Masayasu Kuwahara, Hiroto Fujita, Yuka Kataoka, Seiji Tobita
- Organizer
  The 42nd International Symposium on Nucleic Acids Chemistry (ISNAC2015)
- Place of Presentation
  兵庫・イーグレ姫路
- Year and Date
  2015-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] グアニン四重鎖を標的としたN3位修飾チオフラビンT アナログの創製2015
- Author(s)
  片岡由佳，藤田博仁，笠原勇矢，桑原正靖
- Organizer
  日本化学会第94春季年会(2015)
- Place of Presentation
  日本大学理工学部船橋キャンパス/薬学部
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Isothermal and visual RNA detection system using enzymatic signal amplification and specific emission of thioflavin-T analog2015
- Author(s)
  Hiroto Fujita，Yuka Kataoka，Masayasu Kuwahara
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Capillary electrophoresis-systematic evolution of ligands by exponential enrichment selection using modified nucleic acid libraries2015
- Author(s)
  Masayasu Kuwahara
- Organizer
  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Synthesis and Binding Analysis of Thioflavin T Analogs Targeting G-Quadruplex2014
- Author(s)
  Yuka Kataoka，Hiroto Fujita，Yuuya Kasahara，Toshitada Yoshihara，Seiji Tobita，Masayasu Kuwahara
- Organizer
  3rd Asian Chemical Biology Conference (ACBC3)
- Place of Presentation
  National University of Singapore(NUS), Singapore
- Year and Date
  2014-12-16
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] キャピラリー電気泳動法を用いた人工核酸アプタマーの迅速セレクション法の開発2014
- Author(s)
  桑原正靖，萩原健太，笠原勇矢
- Organizer
  日本分析化学会63年会
- Place of Presentation
  広島大学東広島キャンパス
- Year and Date
  2014-09-17
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Selection of DNA aptamers with base modifications using a capillary electrophoresis-based method2014
- Author(s)
  Yuuya Kasahara，Naoto Honda，Kenta Hagiwara，Masayasu Kuwahara
- Organizer
  The 41st International Symposium on Nucleic Acids Chemistry 2014 (ISNAC2014)
- Place of Presentation
  北九州国際会議場，福岡
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Modified DNA Aptamers that Bind to Vascular Endothelial Growth Factors2014
- Author(s)
  Naoto Honda，Kenta Hagiwara，Yuuya Kasahara，Masayasu Kuwahara
- Organizer
  3rd Asian Chemical Biology Conference (ACBC3)
- Place of Presentation
  National University of Singapore(NUS), Singapore
- Year and Date
  2014-12-16
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] キャピラリー電気泳動法を用いたタンパク質結合性塩基修飾DNAアプタマーの創製2014
- Author(s)
  本田直渡，萩原健太，笠原勇矢，桑原正靖
- Organizer
  日本化学会第8回バイオ関連化学シンポジウム
- Place of Presentation
  岡山大学津島キャンパス
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Switch molecules designed from 2′,4′-BNA aptamers2013
- Author(s)
  Yuuya Kasahara， Yuuta Irisawa， Naoto Honda， Kunihiko Morihiro， Satoshi Obika， Masayasu Kuwahara
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013 (ISNAC2014)
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] NUCLEIC ACID APTAMERS FOR SMALL MOLECULES2013
- Author(s)
  Hiroto Fujita，Yuri Imaizumi，Yuuya Kasahara，Hiroaki Ozaki，Masayasu Kuwahara
- Organizer
  Frontiers of Single Cell Analysis Conference
- Place of Presentation
  Stanford University, Stanford, CA, USA
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] CE-SELEX OF CHIMERIC DNA-BASED APTAMERS2013
- Author(s)
  Yuuya Kasahara， Yuuta Irisawa， Naoto Honda， Satoshi Obika，Masayasu Kuwahara
- Organizer
  Frontiers of Single Cell Analysis Conference
- Place of Presentation
  Stanford University, Stanford, CA, USA
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Effects of tail strands on the binding activity of G-quadruplex DNA aptamers for small molecules2013
- Author(s)
  Hiroto Fujita，Yuri Imaizumi，Yuuya Kasahara，Hiroaki Ozaki，Masayasu Kuwahara
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry 2013 (ISNAC2014)
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] スクリーニング条件が核酸アプタマーの結合特性に及ぼす影響2011
- Author(s)
  笠原勇矢, 入澤祐太, 桑原正靖
- Organizer
  日本化学会第91春季年会(2011)
- Place of Presentation
  神奈川大学横浜キャンパス(神奈川県)
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] スクリーニング条件が核酸アプタマーの結合特性に及ぼす影響2011
- Author(s)
  笠原勇矢, 入澤祐太, 桑原正靖
- Organizer
  日本化学会第91春季年会(2011)
- Place of Presentation
  神奈川大学横浜キャンパス
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Synthesis of acridonyl nucleoside analog and its fluorescent properties and substrate properties on polymerase reaction2010
- Author(s)
  Masayasu Kuwahara, Yuuya Kasahara, Keisuke Anahaza, Yuuta Irisawa, Masayoshi Tajima, Hiroaki Ozaki, Hiroaki Sawai, Akio Sugiyama
- Organizer
  IRT 2010-XD International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Universite Claude Bernard Lyon 1(Lyon, France)
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] 酵素的人工核酸合成における塩基部位/糖部位修飾ヌクレオシド三リン酸の基質特性評価2010
- Author(s)
  高野優貴, 笠原勇矢, 桑原正靖, 杉山明生, 尾崎広明, 澤井宏明
- Organizer
  第4回バイオ関連化学シンポジウム
- Place of Presentation
  大阪大学豊中キャンパス
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation]2010
- Author(s)
  Yuuya Kasahara, Yuuta Irisawa, Hidetaka Okonogi, Masayoshi Tajima, Atsushi Kobayashi, Masayasu Kuwahara, Hiroaki Ozaki, Seiji Tobita
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Hawaii Convention Center
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Measurement of the binding affinity of selectedDNA aptamer by nonequilibrium capillaryelectrophresis2010
- Author(s)
  Yuuya Kasahara, Masayasu Kuwahara
- Organizer
  ISNAC2010
- Place of Presentation
  はまぎんホール(ヴィアマーレ)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Enzymatic synthesis of artificial nucleic acids by various mutants of KOD DNA polymerase2010
- Author(s)
  Kuwahara M., Takano Y., Kasahara Y, Sugiyama A., Ozaki H., Sawai H
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
- Place of Presentation
  ハワイ,ホノルル
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] 酵素的人工核酸合成における塩基部位/糖部位修飾ヌクレオシド三リン酸の基質特性評価2010
- Author(s)
  高野優貴, 笠原勇矢, 桑原正靖, 杉山明生, 尾崎広明, 澤井宏明
- Organizer
  第4回バイオ関連化学シンポジウム
- Place of Presentation
  大阪大学豊中キャンパス(大阪府)
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Synthesis of acridonyl nucleoside analog and its fluorescent properties and substrate properties on polymerase reaction2010
- Author(s)
  Masayasu Kuwahara, Yuuya Kasahara, Keisuke Anahara, Yuuta Irisawa, Irisawa, Masayoshi Tajima, Hiroaki Ozaki, Hiroaki Sawai, Akio Sugiyama
- Organizer
  IRT 2010-XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Universite Claude Bernard Lyon 1
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Synthesis of acridonyl nucleoside analog and its fluorescent properties and substrate properties on polymerase reaction.2010
- Author(s)
  Masayasu Kuwahara, Yuya Kasahara, Keisuke Anahara, Yuta Irisawa, Masayoshi Tajima, Hiroaki Ozaki, Hiroaki Sawai, Akio Sugiyama.
- Organizer
  IRT 2010-XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  リヨン(フランス)
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] アクリドン修飾ヌクレオチドの合成とその特性2010
- Author(s)
  穴原圭佑, 田島正義, 高野優貴, 桑原正靖, 尾崎広明
- Organizer
  第5回相模ケイ素材料フォーラム
- Place of Presentation
  相模中央化学研究所(神奈川県綾瀬市)
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Syntheses and properties of acridone-labeled oligonucleotide analogs with two different backbone structures2010
- Author(s)
  Yuuya Kasahara, Yuuta Irisawa, Hidetaka Okonogi, Masayoshi Tajima, Atsushi Kobayashi, Masayasu Kuwahara, Hiroaki Ozah, Seiji Tobita
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
- Place of Presentation
  Hawaii Convention Center(Honolulu, Hawaii, USA)
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] 酵素的人工核酸合成における塩基部位/糖部位修飾ヌクレオシド三リン酸の基質特性評価2010
- Author(s)
  高野優貴, 笠原勇矢, 桑原正靖, 杉山明生, 尾崎広明, 澤井宏明
- Organizer
  第4回バイオ関連化学シンポジウム
- Place of Presentation
  大阪大学豊中キャンパス(大阪府豊中市)
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] 種々のKOD DNAポリメラーゼ変異体による酵素的人工核酸合成の比較検討2010
- Author(s)
  高野優貴, 笠原勇矢, 桑原正靖, 杉山明生, 尾崎広明, 澤井宏明
- Organizer
  日本化学会第90春季年会(2010)
- Place of Presentation
  近畿大学本部キャンパス(大阪府)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Enzymatic synthesis of artificial nucleic acids by various mutants of KOD DNA polymerase.2010
- Author(s)
  Masayasu Kuwahara, Yuki Takano, Yuya Kasahara, Akio Sugiyama, Hiroaki Ozaki, Hiroaki Sawai.
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  ホノルル(米国)
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] 架橋型ヌクレオチドの3'末キャッピングによるDNAアプタマーのヒト血清中における安定性の評価2010
- Author(s)
  笠原勇矢, 北爪峻輔, 桑原正靖, 尾崎広明, 澤井宏明, 森廣邦彦, 小比賀聡, 今西武
- Organizer
  日本化学会第90春季年会(2010)
- Place of Presentation
  近畿大学本部キャンパス
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Syntheses and properties of acridone-labeled oligonucleotide analogs with two different backbone structures2010
- Author(s)
  Kasahara Y., Irisawa Y., Okonogi H., Tajima M., Kobayashi A., Kuwahara M., Ozaki H., Tobita S.
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)
- Place of Presentation
  ハワイ,ホノルル
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] 種々のKOD DNAポリメラーゼ変異体による酵素的人工核酸合成の比較検討2010
- Author(s)
  高野優貴, 笠原勇矢, 桑原正靖, 杉山明生, 尾崎広明, 澤井宏明
- Organizer
  日本化学会第90春季年会(2010)
- Place of Presentation
  近畿大学本部キャンパス
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Syntheses and properties of acridonelabeled oligonucleotide analogs with two different backbone structures.2010
- Author(s)
  Yuya Kasahara, Yuta Irisawa, Hidetaka Okonogi, Masayoshi Tajima, Atsushi Kobayashi, Masayasu Kuwahara, Hiroaki Ozaki, Seiji Tobita.
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  ホノルル(米国)
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Measurement of the binding affinity of selected DNA aptamer by nonequilibrium capillary electrophoresis.2010
- Author(s)
  Yuya Kasahara, Masayasu Kuwahara.
- Organizer
  The 37th International symposium on Nucleic Acid Chemistry (ISNAC2010)
- Place of Presentation
  はまぎんホール(神奈川県)
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Synthesis of acridonyl nucleoside analog and its fluorescent properties and substrate properties on polymerase reaction2010
- Author(s)
  Kuwahara M, Kasahara Y, Anahara K, Irisawa Y, Tajima M, Ozaki H, Sawai H, Sugiyama A
- Organizer
  IRT 2010-XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids
- Place of Presentation
  Lyon, France
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] Measurement of the binding affinity of selected DNA aptamer by nonequilibrium capillary electrophresis2010
- Author(s)
  Kasahara Y., Kuwahara M.
- Organizer
  The 37th International symposium on Nucleic Acid Chemistry(ISNAC2010)
- Place of Presentation
  横浜,はまぎんホール
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] 酵素的人工核酸合成における塩基部位/糖部位修飾ヌクレオシド三リン酸の基質特性評価2010
- Author(s)
  高野優貴, 笠原勇矢, 桑原正靖, 杉山明生, 尾崎広明, 澤井宏明
- Organizer
  第4回バイオ関連化学シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] アクリドン修飾ヌクレオチドの合成とその特性2010
- Author(s)
  穴原圭佑, 田島正義, 高野優貴, 桑原正靖, 尾崎広明
- Organizer
  第5回相模ケイ素材料フォーラム
- Place of Presentation
  相模中央化学研究所
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Measurement of the binding affinity of selected DNA aptamer by nonequilibrium capillary electrophresis2010
- Author(s)
  Yuuya Kasahara, Masayasu Kuwahara
- Organizer
  The 37th International symposium on Nucleic Acid Chemis(ISNAC2010)
- Place of Presentation
  はまぎんホール(ヴィアマーレ)(神奈川県横浜市)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] 架橋型ヌクレオチドの3'末キャッピングによるDNAアプタマーのヒト血清中における安定性の評価2010
- Author(s)
  笠原勇矢, 北爪峻輔, 桑原正靖, 尾崎広明, 澤井宏明, 森廣邦彦, 小比賀聡, 今西武
- Organizer
  日本化学会第90春季年会(2010)
- Place of Presentation
  近畿大学本部キャンパス(大阪府)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] C5位修飾アラビノヌクレオチドのDNA鎖への酵素的導入2009
- Author(s)
  笠原勇矢, 高野優貴, 奈良紘希, 桑原正靖, 尾崎広明
- Organizer
  第24回生体機能関連化学シンポジウム, 第12回バイオテクノロジー部会シンポジウム
- Place of Presentation
  九州大学医系キャンパス百年記念講堂(福岡)
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] 種々の2', 4'架橋型ヌクレオチドを用いた酵素的DNA修飾およびヒト血清中における安定性の比較検討2009
- Author(s)
  北爪峻輔, 桑原正靖, 尾崎広明, 小比賀聡
- Organizer
  日本化学会第3回関東支部大会(2009)
- Place of Presentation
  早稲田大学理工キャンパス
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] DNA鎖の主鎖修飾がポリメラーゼ反応に及ぼす影響2009
- Author(s)
  桑原正靖, 竹島英俊, 峯崎賢巳, 太田裕貴, 尾崎広明, 澤井宏明
- Organizer
  第3回バイオ関連化学合同シンポジウム
- Place of Presentation
  神奈川
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] C5位修飾アラビノヌクレオチドのDNA鎖への酵素的導入2009
- Author(s)
  笠原勇矢, 高野優貴, 奈良紘希, 桑原正靖, 尾崎広明
- Organizer
  第24回生体機能関連化学シンポジウム, 第12回バイオテクノロジー部会シンポジウム
- Place of Presentation
  九州大学医系キャンパス(百年記念講堂)
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] 種々の2',4'架橋型ヌクレオチドを用いた酵素的DNA修飾およびヒト血清中における安定性の比較検討2009
- Author(s)
  北爪峻輔, 桑原正靖, 尾崎広明, 小比賀聡
- Organizer
  日本化学会第3回関東支部大会(2009)
- Place of Presentation
  早稲田大学理工キャンパス(東京都)
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] DNA二重鎖中におけるアクリドニル基の塩基認識2009
- Author(s)
  桑原正靖, 田島正義, 尾崎広明
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  日本大学理工学部船橋キャンパス
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Fluorescent properties of acridonyl group in DNA duplex2009
- Author(s)
  M.Kuwahara, A.Kobayashi, M.Tajima, S.Kitazume, K.Anahara, H.Oazaki, S.Tobita
- Organizer
  The 6th International Symposium on Nucleic Acid Chemistry
- Place of Presentation
  高山文化会館
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] C5位修飾アラビノヌクレオチドのDNA鎖への酵素的導入2009
- Author(s)
  笠原勇矢, 高野優貴, 奈良紘希, 桑原正靖, 尾崎広明
- Organizer
  第24回生体機能関連化学シンポジウム,第12回バイオテクノロジー部会シンポジウム
- Place of Presentation
  九州大学医系キャンパス(百年記念講堂)(福岡県)
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] DNA二重鎖中におけるアクリドニル基の塩基認識2009
- Author(s)
  桑原正靖, 田島正義, 尾崎広明
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  千葉
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] Fluorescent properties of acridonyl group in DNA duplex2009
- Author(s)
  Masayasu Kuwahara, Atsushi Kobayashi, Masayoshi Tajima, Shunsuke Kitazume, Keisuke Anahara, Hiroaki Oazaki, Seiji Tobita.
- Organizer
  The 6th International Symposium on Nucleic Acid Chemistry
- Place of Presentation
  高山文化会館(岐阜)
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-21710221
[Presentation] C5位修飾アラビノヌクレオチドのDNA鎖への酵素的導入2009
- Author(s)
  笠原勇矢, 高野優貴, 奈良紘希, 桑原正靖, 尾崎広明
- Organizer
  第24回生体機能関連化学シンポジウム,第12回バイオテクノロジー部会シンポジウム
- Place of Presentation
  九州大学医系キャンパス百年記念講堂
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Fluorescent properties of acridonyl group in DNA duplex2009
- Author(s)
  桑原正靖, 小林敦, 田島正義, 北爪峻輔, 穴原圭祐, 尾崎広明, 飛田成史
- Organizer
  36th International Symposium on Nucleic Acid Chemistry
- Place of Presentation
  高山文化会館(岐阜)
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] Fluorescent properties of acridonyl group in DNAduplex2009
- Author(s)
  桑原正靖, 小林敦, 田島正義, 北爪峻輔, 穴原圭祐, 尾崎広明, 飛田成史
- Organizer
  36th International Symposium onNucleic Acid Chemistry
- Place of Presentation
  高山文化会館
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] 2', 4'-架橋型ヌクレオシドの酵素的DNA末端標識とヌクレアーゼ耐性の評価2009
- Author(s)
  萩原慶彦, 竹島英俊, 桑原正靖, 尾崎広明, 澤井宏明, 小比賀聡, 今西武
- Organizer
  日本化学会第89春季年会
- Place of Presentation
  千葉
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] 人工核酸アプタマー〜生命計測や医薬・診断薬への応用を目指して~2008
- Author(s)
  桑原正靖
- Organizer
  日本化学会生命化学研究会
- Place of Presentation
  群馬
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] DNAの二次構造を認識する修飾DNAアプタマーの最小化とその機能評価2008
- Author(s)
  桑原正靖・森角裕平・笠松敏幸・尾崎広明・澤井宏明
- Organizer
  日本化学会第88回春季年会
- Place of Presentation
  東京
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] Effect of backbone-modification of oligodeoxyribonucleic acidon primer extension reactions2008
- Author(s)
  M. Kuwahara, Minezaki, J
- Organizer
  Joint Symposium of the 18th International Roundtable onNucleos ides, Nucleotides and Nucleic Acidsand the 35th International Symposium on Nucleic Acids Chemistr
- Place of Presentation
  京都大学
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] DNAの主鎖リン酸部位の改変がポリメラーゼ反応に及ぼす影響2008
- Author(s)
  永島潤一, 峯崎賢巳, 桑原正靖, 尾崎広明, 澤井宏明
- Organizer
  第10回生命化学研究会シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2008-01-11
- Data Source
  KAKENHI-PROJECT-17710179
[Presentation] 末端デオキシヌクレオチド転移酵素に対する2', 4'-架橋型ヌクレオシド三リン酸の基質特性の評価2008
- Author(s)
  竹島英俊, 桑原正靖, 小比賀聡, 尾崎広明, 澤井宏明, 今西武
- Organizer
  日本化学会第2回関東支部大会
- Place of Presentation
  群馬
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] ffect of backbone-modification of oligodeoxyribonucleic acid onprimer extension reactions.2008
- Author(s)
  M. Kuwahara Minezaki, J
- Organizer
  Joint Symposium of the 18th International Roundtable on Nucleos ides, Nucleotides and Nucleic Acids and the 35th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  京都大学吉田キャンパス
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] DNA鎖の主鎖修飾がポリメラーゼ反応に及ぼす影響2008
- Author(s)
  桑原正靖、竹島英俊
- Organizer
  第3回バイオ関連化学合同シンポジウム
- Place of Presentation
  京工業大学すずかけ台キャンパス
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-20360374
[Presentation] 主鎖骨格修飾ヌクレオチドを含むDNA鋳型鎖を用いたポリメラーゼ反応2008
- Author(s)
  永島潤一・峯崎賢巳・桑原正靖・尾崎広明・澤井宏明
- Organizer
  日本化学会第88回春季年会
- Place of Presentation
  東京
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] DNAの二次構造を認識する修飾DNAアプタマーの最小化とその機能評価2008
- Author(s)
  桑原正靖・森角裕平・笠松敏幸・尾崎広明・澤井宏明
- Organizer
  日本化学会第88回春季年会
- Place of Presentation
  東京
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17710179
[Presentation] 主鎖骨格修飾ヌクレオチドを含むDNA鋳型鎖を用いたポリメラーゼ反応2008
- Author(s)
  永島潤一・峯崎賢巳・桑原正靖・尾崎広明・澤井宏明
- Organizer
  日本化学会第88回春季年会
- Place of Presentation
  東京
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17710179
[Presentation] DNAポリメラーゼによる主鎖骨格修飾鋳型鎖の配列読取り2007
- Author(s)
  峯崎賢巳, 永島潤一;桑原正靖, 尾崎広明, 澤井宏明
- Organizer
  第22回生体機能関連化学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-17710179
[Presentation] 人工核酸分子の可能性〜核酸医薬・診断薬の創製をめざして2007
- Author(s)
  桑原正靖
- Organizer
  第22回生体機能関連化学シンポジウム「若手フォーラム」
- Place of Presentation
  仙台
- Year and Date
  2007-09-30
- Data Source
  KAKENHI-PROJECT-17710179
[Presentation] Synthesis of acridonyl-dUTP analog and its substrate property during a polymerase reaction2007
- Author(s)
  Masayasu Kuwahara, Jun-ichi Nagashima, Hidetoshi Takeshima, Hiroaki Ozaki and Hiroaki Sawai
- Organizer
  The 2nd international workshop on approaches to single-cellanalysis
- Place of Presentation
  東京
- Year and Date
  2007-09-07
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] DNAポリメラーゼによる主鎖骨格修鋳型鎖の配列読取り2007
- Author(s)
  峯崎賢巳, 永島潤一, 桑原正靖, 尾崎広明, 澤井宏明
- Organizer
  第22回生体機能関連化学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-19021008
[Presentation] DNA Aptamers Containing 2'-Deoxy-2'-Fluoroguanosine
- Author(s)
  Kenta Hagiwara，Yuuya Kasahara，Yuuta Irisawa，Masayasu Kuwahara
- Organizer
  XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids (IRT2014)
- Place of Presentation
  Poznaｎ, Poland
- Year and Date
  2014-08-25 – 2014-08-26
- Data Source
  KAKENHI-PROJECT-25350962
[Presentation] Modified DNA Aptamer-Based Separation of Small Molecules by Capillary Electrophoresis
- Author(s)
  Yuuya Kasahara，Yurika Watanabe，Masayasu Kuwahara
- Organizer
  XXI Round Table on Nucleosides, Nucleotides and Nucleic Acids (IRT2014)
- Place of Presentation
  Poznaｎ, Poland
- Year and Date
  2014-08-25 – 2014-08-26
- Data Source
  KAKENHI-PROJECT-25350962

1. FUKUSAKI Eiichiro (40273594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. TAKAMURA Yuzuru (20290877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. OKAZAWA Atsushi (10294042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. INOUE Yusuke (90304302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NAMEKI Nobukazu (80302959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OBIKA Satoshi (80243252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. SAWAI Hiroaki (70012648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OZAKI Hiroaki (90211820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. Masanobu Yamada (90261833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 篠塚和夫 (20206105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 河島尚志 (70224772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 小澤厚志 (10573496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 堀口和彦 (10737943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 佐藤哲郎 (40302484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 石井角保 (60638112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中島康代 (70707017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渋沢信行 (90396622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 藤田博仁 (60822244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
19. 片岡由佳 (20978796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. 笠原勇矢 (10740673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 細田忠弘 (31017734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 山口朋子 (50580130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ENDOH Tamaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 沢井宏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
25. 林宏樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwahara Masayasu 桑原 正靖

KUWAHARA Masayasu 桑原 正靖

Research Projects

Research Products

Co-Researchers

Development of functional nucleic acid molecules using a blood-brain barrier model

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Development of intracellular microRNA imaging technology using SATIC methodPrincipal Investigator

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Development of a simple gene mutation detection method and verification of the frequency of drug-resistant virusesPrincipal Investigator

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Insight into mechanisims undelying Primary aldosteronism

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Creation of xenonucleic acid switch moleculesPrincipal Investigator

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Study of the nuclear receptors involved in fatty livers; establishment of a new pathological model and development of therapeutic application.

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Design and creation of condition-responsive nano-drug-carriers involving by the step-wise construction method using intelligent nucleic acidsPrincipal Investigator

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Development of fundamental technology for accurate RNAomics

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1分子シーケンスに資する化学修飾DNA断片および核酸基質アナログの創製Principal Investigator

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1分子シーケンシングに適したDNA断片の簡便な調製法の開発Principal Investigator

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多重修飾DNAライブラリを用いた応用インビトロ・セレクション法の開発Principal Investigator

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一塩基多型(SNPs)検出のための修飾DNAアプタマーの創製Principal Investigator

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一塩基多型(SNPs)検出のための修飾DNAアプタマーの創製Principal Investigator

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Kuwahara Masayasu 桑原正靖

KUWAHARA Masayasu 桑原正靖

[Book] 月刊化学四月号(核酸アプタマーのケミカル・ルネサンス)2009

[Book] 「核酸アプタマーのケミカル・ルネサンス」月刊化学四月号2009

[Book] ゲノムケミストリー/第4章2節「人工修飾核酸を用いた試験管内選択法(セレックス法)の拡張」(関根光雄・齋藤烈編)2003