Higuchi Takuma 樋口琢磨

… Alternative Names

HIGUCHI Takuma 樋口琢磨

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Researcher Number	10754567
Other IDs
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系基礎医学部門, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 高知大学, 教育研究部医療学系基礎医学部門, 助教 2015: 高知大学, 教育研究部医療学系基礎医学部門, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 48040:Medical biochemistry-related / General medical chemistry Except Principal Investigator Medium-sized Section 39:Agricultural and environmental biology and related fields / General medical chemistry
Keywords	Principal Investigator NF45 / NF90 / miRNA / NASH / マイクロRNA / microRNA / RNA結合タンパク質 / RBPs / 肝臓特異的ノックアウトマウス / 肝細胞がん … More / 非アルコール性脂肪肝炎 / 臓器特異的ノックアウトマウス / 炎症 / 線維化 / デコイRNA / フィードバックループ / RNA二次構造 / がん … More Except Principal Investigator 哺乳動物細胞の遺伝資源保存 / 初期胚のエピゲノム / 乾燥耐性 / 哺乳動物細胞 / 哺乳類の初期発生機構 / 発生機構 / 遺伝子資源保存 / フリーズドライ / 凍結乾燥保存 / 哺乳動物 / 遺伝資源保存 / 生殖工学 / 体細胞 / 精子 / 哺乳動物遺伝資源 / 凍結乾燥 / Dynamin2 / ミオパチー / 筋萎縮 / Dynamin / マイクロRNA / 筋成熟 / 骨格筋 / 中心核 / 筋再生 / NF45 / NF90 / Dynamin 2 / 中心核病 / 筋分化 / miRNA / microRNA生合成 / 二本鎖RNA結合蛋白質 Less

miRNA生合成阻害因子によるNASH発症・増悪化の新たな調節機構の解明Principal Investigator
- Principal Investigator
  
  樋口琢磨
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kochi University
The effect of RNA binding proteins on regulatory mechanisms of anti-fibrotic and anti-inflammatory miRNA biogenesisPrincipal Investigator
- Principal Investigator
  
  Higuchi Takuma
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kochi University
Preservation of mammalian genetic resources and study for the developmental mechanism using freeze-dried cells
- Principal Investigator
  
  Matsukawa Kazutsugu
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 39:Agricultural and environmental biology and related fields
- Research Institution
  Kochi University
Regulatory mechanisms of miRNA biogenesis which is involved in tumorigenesis for approach to cancer therapyPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Takuma
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kochi University
A novel RNA metabolism involved in cell differentiation and survival
- Principal Investigator
  
  Shuji Sakamoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kochi University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis2024
- Author(s)
  MATSUMOTO Ken-ichi、HIGUCHI Takuma、UMEKI Mirei、ONO Masafumi、SAKAMOTO Shuji
- Journal Title
  
  Biomed. Res.
  
  Volume: 45 Issue: 2 Pages: 67-76
- DOI
  10.2220/biomedres.45.67
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2024-03-22
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06402, KAKENHI-PROJECT-23K07417
[Journal Article] YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates2021
- Author(s)
  Kawamura Kaz、Higuchi Takuma、Fujiwara Shigeki
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 41 Issue: 7
- DOI
  10.1128/mcb.00047-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16523
[Journal Article] Characteristic analysis of a secondary structure of primary microRNA bound to a double-strand RNA-binding protein, NF902021
- Author(s)
  Higuchi Takuma、Kiernan Rosemary、Sakamoto Shuji
- Journal Title
  
  Electrophoresis Letters
  
  Volume: 65 Issue: 1 Pages: 13-16
- DOI
  10.2198/electroph.65.13
- NAID
  130008048996
- ISSN
  2189-2628, 2189-2636
- Language
  Japanese
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07370, KAKENHI-PROJECT-19K16523
[Journal Article] NF90 modulates processing of a subset of human pri-miRNAs2020
- Author(s)
  Giuseppa Grasso, Takuma Higuchi, Victor Mac, Jerome Barbier, Marion Helsmoortel, Claudio Lorenzi, Gabriel Sanchez, Maxime Bello, William Ritchie, Shuji Sakamoto, Rosemary Kiernan.
- Journal Title
  
  Nucleic Acids Research.
  
  Volume: 48 Issue: 12 Pages: 6874-6888
- DOI
  10.1093/nar/gkaa386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07370, KAKENHI-PROJECT-19K16523
[Journal Article] Candidate plasticity gene 16 mediates suppression of insulin gene expression in rat insulinoma INS-1 cells under glucotoxic conditions.2019
- Author(s)
  Nakane T, Ido A, Higuchi T, Todaka H, Morisawa K, Nagamine T, Fukunaga K, Sakamoto S, Murao K, Sugiyama Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 512 Issue: 2 Pages: 189-195
- DOI
  10.1016/j.bbrc.2019.03.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08590, KAKENHI-PROJECT-17K15601, KAKENHI-PROJECT-18K06134, KAKENHI-PROJECT-18K15850, KAKENHI-PROJECT-19K16523
[Journal Article] A negative feedback loop between nuclear factor 90 (NF90) and an anti-oncogenic microRNA, miR-72018
- Author(s)
  Takuma Higuchi, Keiko Morisawa, Hiroshi Todaka, Sylvia Lai, Eunsup Chi, Kazutsugu Matsukawa, Yasunori Sugiyama, Shuji Sakamoto
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 3 Pages: 1819-1824
- DOI
  10.1016/j.bbrc.2018.07.119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06134, KAKENHI-PROJECT-18K15850, KAKENHI-PROJECT-16K08590, KAKENHI-PROJECT-16K19410, KAKENHI-PROJECT-17K15601
[Journal Article] An NF90/NF110-Mediated Feedback Amplification Loop Regulates DICER Expression and Controls Ovarian Carcinoma Progression.2018
- Author(s)
  Barbier J, Chen X, Sanchez G, Cai M, Helsmoortel M, Higuchi T, Giraud P, Contreras X, Yuan G, Feng Z, Nait-Saidi R, Deas O, Bluy L, Judde JG, Rouquier S, Ritchie W, Sakamoto S, Xie D, and Kiernan R
- Journal Title
  
  Cell Research
  
  Volume: 28 Issue: 5 Pages: 556-571
- DOI
  10.1038/s41422-018-0016-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08590, KAKENHI-PROJECT-17K15601
[Journal Article] A negative feedback loop between nuclear factor 90 (NF90) and an anti-oncogenic microRNA2018
- Author(s)
  Higuchi, T., Morisawa, K., Todaka, H., Lai, S., Chi, E., Matsukawa,K., Sugiyama, Y., Sakamoto, S.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Pages: 1819-1824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03953
[Journal Article] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice.2016
- Author(s)
  Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 6 Pages: 584-592
- DOI
  10.1111/hepr.12587
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09009, KAKENHI-PROJECT-15K09010, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011, KAKENHI-PROJECT-25460315, KAKENHI-PROJECT-25460371, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-16K19351
[Journal Article] Expression and phosphorylation state analysis of intracellular protein kinases using Multi- PK antibody and Phos- tag SDS- PAGE.2015
- Author(s)
  Sugiyama, Y., Katayama, S., Kameshita, I., Morisawa, K., Higuchi, T., Todaka, H., Eiji Kinoshita, Kinoshita- Kikuta, E., Koike, T., Taniguchi, T., Sakamoto, S.
- Journal Title
  
  MethodsX
  
  Volume: 2 Pages: 469-474
- DOI
  10.1016/j.mex.2015.11.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07887, KAKENHI-PROJECT-26460036, KAKENHI-PROJECT-26750372, KAKENHI-PROJECT-14J07002, KAKENHI-PROJECT-25460371, KAKENHI-PROJECT-25560417, KAKENHI-PROJECT-25293005
[Journal Article] Overexpression of NF90-NF45 complex functions as a negative regulation in the microRNA precessing pathway.2015
- Author(s)
  Todaka H, Higuchi T, Yagyu KI, Sugiyama Y, Yamaguchi F, Morisawa K, Ono M, Fukushima A, Tsuda M, Taniguchi T, Sakamoto S.
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460371
[Journal Article] Bofutsushosan, a Japanese herbal (Kampo) medicine, attenuates progression of nonalcoholic steatohepatitis in mice2013
- Author(s)
  Masafumi Ono, Mitsunari Ogasawara, Akira Hirose, Sachiko Mogami, Nobuhiro Ootake, Kosuke Aritake, Takuma Higuchi, Nobuto Okamoto, Shuji Sakamoto, Masahiro Yamamoto, Yoshihiro Urade, Toshiji Saibara, Jude A. Oben.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 49(6) Issue: 6 Pages: 1065-1173
- DOI
  10.1007/s00535-013-0852-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J10660, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-25460371, KAKENHI-PROJECT-25460999, KAKENHI-PROJECT-26461010, KAKENHI-PROJECT-26461011
[Presentation] Sigma-1受容体の骨格筋における筋分化および筋再生促進作用2024
- Author(s)
  戸高寛、有川幹彦、野口達哉、市川厚、樋口琢磨、坂本修士、佐藤隆幸
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K07417
[Presentation] Evaluation of infiltrating CD68 macrophages and myofiber crosssectional area in the skeletal muscle of mdx mice after oral administration of Neu REFI2024
- Author(s)
  Abraham Samuel JK, Shuji Sakamoto, Takuma Higuchi, Yoshitsugu Aoki, Minegishi Katsura, Nobunao Ikewaki, Koji Ichiyama, Kadalraja Raghavan, RaJappa Senthilkymar, Senthikumar Rreethy, Masaru Iwasaki
- Organizer
  2024 MDA Clinical & Scientific Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07417
[Presentation] シグマ1受容体は筋再生機構において筋分化を促進する2023
- Author(s)
  戸高寛、有川幹彦、野口達哉、市川厚、樋口琢磨、坂本修士、佐藤隆幸
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K07417
[Presentation] 二本鎖RNA結合タンパク質複合体NF90-NF45によるm6A修飾制御を介したがん抑制miRNA生合成調節2023
- Author(s)
  樋口琢磨、森岡俊介、森澤啓子、鈴木健之、坂本修士
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K07417
[Presentation] フリーズドライ線維芽細胞を用いたウシ核移植胚の体内発生能2023
- Author(s)
  松川和嗣、亀田崇史、竹中由布、池上正紘、樋口琢磨、坂本修士、枝重圭祐
- Organizer
  日本畜産学会第131回大会
- Data Source
  KAKENHI-PROJECT-23K07417
[Presentation] Muscle regeneration, MYH3 & CD44 increase in mdx mice, with Neu REFIX - β Glucan2023
- Author(s)
  Abraham Samuel JK, 坂本修士, 樋口琢磨, 市山浩二, 山本直樹, Vidyasagar Devaprasad Dedeepiya, 池脇信直, 岩崎甫、Mathaiyan Rajmohan, RaJappa Senthilkymar
- Organizer
  第9回日本筋学会学術集会/第10回筋ジストロフィー医療研究会合同学術集会
- Data Source
  KAKENHI-PROJECT-23K07417
[Presentation] 認知症治療薬ドネペジルはSigma1受容体を介して筋再生を促進する2022
- Author(s)
  戸高寛、有川幹彦、野口達哉、市川厚、樋口琢磨、坂本修士、佐藤隆幸
- Organizer
  第30回日本病態生理学会大会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] 二本鎖RNA結合タンパク質(RBP)による筋分化制御因子MyoDの転写活性化2021
- Author(s)
  坂本修士、樋口琢磨、古株彰一、藤田浩志、池恩燮、森澤啓子、絹川勝晶、戸高寛、松川和嗣、杉山康憲、津田雅之
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] RNA結合タンパク質による腫瘍血管新生の新規分子メカニズムの探索2020
- Author(s)
  藤田浩志、樋口琢磨、森澤啓子、Sylvia Lai, 山口輝, 坂本修士
- Organizer
  第61回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] 二本鎖RNA結合タンパク質が結合するマイクロRNA初期転写産物の構造的特徴の解析2020
- Author(s)
  樋口琢磨、坂本修士
- Organizer
  第70回日本電気泳動学会シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] マイクロRNAの機構を介した骨格筋の細胞融合及び成熟化の新規制御機構2020
- Author(s)
  坂本修士、山口輝、森澤啓子、樋口琢磨、Lai Sylvia、池恩燮、藤田浩志、杉山康憲、松川和嗣、津田雅之
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] 筋分化過程の筋芽細胞における二本鎖RNA結合タンパク質の関与2019
- Author(s)
  坂本修士, 山口輝, 樋口琢磨, 森澤啓子, Sylvia Lai, 戸高寛, 池恩燮, 藤田浩志, 杉山康憲, 津田雅之
- Organizer
  第60回日本生化学会中国四国支部例会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] 骨格筋の分化・成熟化における細胞融合促進因子の新たな発現制御機構2019
- Author(s)
  坂本修士, 山口輝, 樋口琢磨, 森澤啓子, 戸高寛, Sylvia Lai, 池恩燮, 藤田浩志, 杉山康憲, 松川和嗣, 津田雅之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] 非アルコール性脂肪肝炎モデルマウスの肝臓において発現増加する二本鎖RNA結合タンパク質NF90の機能解析2019
- Author(s)
  樋口琢磨, 宗景玄祐, 矢生健一, 森澤啓子, Sylvia Lai, 山口輝, 藤田浩志, 津田雅之,小野正文, 坂本修士
- Organizer
  第60回日本生化学会中国四国支部例会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] ウシ凍結乾燥体細胞を用いて作出した核移植胚におけるヒストンH3のメチル化および遺伝子発現2019
- Author(s)
  岡村早穂、本郷新、田村慎之介、赤木悟史、竹中由布、樋口琢磨、坂本修士、枝重圭祐、井上梓、松川和嗣
- Organizer
  日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-18H03953
[Presentation] 骨格筋の細胞融合及び成熟化におけるRNA結合タンパク質の役割の解明2019
- Author(s)
  坂本修士, 山口輝, 森澤啓子, 樋口琢磨, 戸高寛, Sylvia Lai, 池恩燮, 藤田浩志, 杉山康憲, 松川和嗣, 津田雅之
- Organizer
  日本筋学会第5回学術集会
- Data Source
  KAKENHI-PROJECT-19K16523
[Presentation] 骨格筋において二本鎖 RNA結合タンパク質複合体 NF90-NF45の過剰発現が引き起こす筋成熟化抑制2018
- Author(s)
  坂本修士、森澤啓子、樋口琢磨、Sylvia Lai、戸高寛、池恩燮、杉山康憲、津田雅之
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] Nuclear Factor 90(NF90)の発現はmiR-7を介したフィードバックループにより制御される2018
- Author(s)
  樋口琢磨, 戸高寛, 森澤啓子, Sylvia Lai, 池恩燮, 杉山康憲, 坂本修士
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 哺乳動物細胞におけるフリーズドライ保存の可能性と課題2018
- Author(s)
  松川　和嗣, 本郷新, 井上　陽香, 横山輝智香, 森澤　啓子, 樋口　琢磨, 坂本　修士, 及川　俊徳, 斎藤　公治, 赤木　悟史, 武田　久美子, 黄川田　隆洋, 市川　明彦, 枝重　圭祐
- Organizer
  Cryopreservation Conference 2018
- Data Source
  KAKENHI-PROJECT-18H03953
[Presentation] RNA結合タンパク質複合体 NF45-NF90は膵β細胞のアポトーシスを抑制する2018
- Author(s)
  Sylvia Lai、樋口琢磨、杉山康憲、森澤啓子、津田雅之、坂本修士
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 膵臓β細胞におけるコレステロール合成を介したインスリン発現抑制機構2018
- Author(s)
  飯田悟史、藤井修作、井戸彩詠、戸高寛、樋口琢磨、坂本修士、村尾孝児、杉山康憲
- Organizer
  第59回日本生化学会中四国支部例会
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] ウシ除核卵母細胞を用いた雄性発生胚の効率的作出2018
- Author(s)
  本郷新、樋口琢磨、坂本修士、赤木悟史、武田久美子、及川俊徳、枝重圭祐、松川和嗣
- Organizer
  第111回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-18H03953
[Presentation] 膵臓β細胞におけるCPG16-JDP2を介した新規インスリン発現抑制機構2018
- Author(s)
  中根達人、井戸彩詠、樋口琢磨、戸高寛、坂本修士、村尾孝児、杉山康憲
- Organizer
  第59回日本生化学会中四国支部例会
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 膵臓β細胞におけるコレステロール増加はインスリン発現を抑制する2017
- Author(s)
  藤井修作、飯田悟史、戸高寛、樋口琢磨、坂本修士、村尾孝児、杉山康憲
- Organizer
  2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学会大会)
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 骨格筋において過剰発現した NF90-NF45は赤筋化を誘導する2017
- Author(s)
  坂本修士、森澤啓子、Sylvia Lai、樋口琢磨、戸高寛、池恩燮、杉山康憲、津田雅之
- Organizer
  2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学会大会)
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 凍結乾燥によるマウス胚性線維芽細胞の保存2017
- Author(s)
  宮野友里、本郷新、田村慎之介、樋口琢磨、坂本修士、枝重圭祐、松川和嗣
- Organizer
  Cryopreservation Conference 2017
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] NASH モデルマウスの肝細胞において Nuclear Factor 90 の発現は増加する2017
- Author(s)
  樋口琢磨、宗景玄祐、矢生健一、Sylvia Lai、松川和嗣、津田雅之、小野正文、坂本修士
- Organizer
  2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学会大会)
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] RNA 結合タンパク質を介した新たな膵β細胞増殖機構の解明2017
- Author(s)
  Sylvia Lai、樋口琢磨、津田雅之、森澤啓子、杉山康憲、坂本修士
- Organizer
  2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学会大会)
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 夏期の柚子果皮給与が褐毛和種高知系の肥育に与える影響ーオミクス解析による検討2017
- Author(s)
  薮本美月、岩本侑希子、樋口琢磨、坂本修士、森澤啓子、岩佐茜、久保里加、宅谷はるこ、竹中由布、竹村泰雄、垣渕和正、石田豊、松川和嗣
- Organizer
  日本畜産学会第123回大会
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 糖毒性状態の膵臓β細胞において Dclk1はインスリンの発現を抑制する2017
- Author(s)
  井戸彩詠、樋口琢磨、戸高寛、坂本修士、村尾孝児、杉山康憲
- Organizer
  2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会・第90回日本生化学会大会)
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 二本鎖 RNA 結合タンパク質によるケモカイン CXCL5 の発現制御を介した癌細胞の浸潤能制御機構の解明2017
- Author(s)
  樋口琢磨、三輪武司、森澤啓子、Sylvia Lai、坂本修士
- Organizer
  第58回日本生化学会中国・四国地区支部例会
- Data Source
  KAKENHI-PROJECT-17K15601
[Presentation] 過剰発現したNF90-NF45複合体は筋サテライト細胞発生のマスター因子であるPax7の発現増加を引き起こす.2015
- Author(s)
  戸高寛, 樋口琢磨, 三輪武司, 森澤啓子, Lai Sylvia Chin See, 有川幹彦, 佐藤隆幸, 津田雅之, 坂本修士.
- Organizer
  Biochemistry and Molecular Biology 2015
- Place of Presentation
  神戸ポートアイランド (神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] 膵臓における二本鎖RNA結合タンパク質NF90及びNF45の機能解析.2015
- Author(s)
  2. Lai Sylvia Chin See, 樋口琢磨, 杉山康憲, 森澤啓子, 戸高寛, 三輪武司, 津田雅之, 坂本修士.
- Organizer
  Biochemistry and Molecular Biology 2015
- Place of Presentation
  神戸ポートアイランド (神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] 抗がん剤を処理したヒト白血病細胞HL-60の細胞内キナーゼの発現およびリン酸化動態の解析.2015
- Author(s)
  杉山康憲, 片山将一, 亀下勇, 森澤啓子, 樋口琢磨, 戸高寛, 木下英司, 木下-菊田恵美子, 小池透, 坂本修士.
- Organizer
  Biochemistry and Molecular Biology 2015
- Place of Presentation
  神戸ポートアイランド (神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] 肝細胞癌における二本鎖RNA結合タンパク質によるケモカイン，CXCL5の発現制御機構.2015
- Author(s)
  三輪武司, 樋口琢磨, 戸高寛, 森澤啓子, Lai Sylvia Chin See, 坂本修士.
- Organizer
  Biochemistry and Molecular Biology 2015
- Place of Presentation
  神戸ポートアイランド (神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] NF90-NF45 complex impairs muscular maturation via blockade of miR-133 biogenesis.2013
- Author(s)
  Todaka H, Higuchi T, Yagyu K, Yamaguchi F, Morisawa K, Fukushima A, Tsuda M, Sugiyama Y, Sakamoto S.
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド (神戸)
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] Overexpression of NF90-NF45 complex causes centronuclear muscle fibers through blockade of microRNA biogenesis.2013
- Author(s)
  Todaka H, Higuchi T, Yagyu K, Yamaguchi F, Morisawa K, Fukushima A, Tsuda M, Sugiyama Y, Sakamoto S.
- Organizer
  第15回RNA学会年会
- Place of Presentation
  愛媛県県民文化会館ひめぎんホール (愛媛)
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] NF90及びNF45によるmiRNA-7生合成阻害を介した腫瘍化制御機構の解明2013
- Author(s)
  樋口琢磨, 戸高寛, 池恩秀, 山口史佳, 森澤啓子, 小野正文, 杉山康憲, 津田雅之, 坂本修士, 谷口武利.
- Organizer
  第54回日本生化学会中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂 (徳島)
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] NF90-NF45 regulates an expression of EGFR through suppression of miR-7 biogenesis in hepatocellular carcinoma.2013
- Author(s)
  Higuchi T, Todaka H, Morisawa K, Yamaguchi F, Ono M, Sugiyama Y, Tsuda M, Sakamoto S.
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド (神戸)
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] Suppression of miR-7 biogenesis by NF90-NF45 complex in Hepatocellular Carcinoma.2013
- Author(s)
  Higuchi T, Todaka H, Yamaguchi F, Morisawa K, Ono M, Sugiyama Y, Tsuda M, Sakamoto S.
- Organizer
  第15回RNA学会年会
- Place of Presentation
  愛媛県県民文化会館ひめぎんホール (愛媛)
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] Identification of a motif in NF90 protein that is involved in inhibition of microRNA biogenesis.2013
- Author(s)
  Yamaguchi F, Todaka H, Higuchi T, Morisawa K, Sugiyama Y, Sakamoto S.
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド (神戸)
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] NF90-NF45複合体によるmiRNA産生調節を介した筋成熟抑制2013
- Author(s)
  戸高寛, 樋口琢磨, 矢生健一, 森澤啓子, 山口史佳, 池恩秀, 福島敦樹, 津田雅之, 杉山康憲, 坂本修士.
- Organizer
  第54回日本生化学会中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂 (徳島)
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] マルチPK抗体とPhos-tagを利用した細胞内リン酸化シグナリング解析法
- Author(s)
  杉山康憲, 森澤啓子, 樋口琢磨, 戸高寛, 山口史佳, 安東徳子, 坂本修士.
- Organizer
  第87回日本生化学会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460371
[Presentation] 二本鎖RNA結合タンパク質が関与する肝細胞癌の新たな遊走能制御
- Author(s)
  樋口琢磨, 安東徳子, 三輪武司, 戸高寛, 森澤啓子, Lai Chin See Sylvia, 杉山康憲, 津田雅之, 坂本修士.
- Organizer
  第87回日本生化学会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460371

1. Shuji Sakamoto (80397546)

# of Collaborated Projects: 3 results

# of Collaborated Products: 34 results
2. Todaka Hiroshi (80769662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
3. Matsukawa Kazutsugu (00532160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 市川明彦 (20377823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 枝重圭祐 (30175228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 武田久美子 (60414695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 黄川田隆洋 (60414900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 赤木悟史 (70414696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 及川俊徳 (70588962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 郡七海 (30966289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 杉山康憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 小野正文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 西原利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 木下恵美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higuchi Takuma 樋口 琢磨

HIGUCHI Takuma 樋口 琢磨

Research Projects

Research Products

Co-Researchers

miRNA生合成阻害因子によるNASH発症・増悪化の新たな調節機構の解明Principal Investigator

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The effect of RNA binding proteins on regulatory mechanisms of anti-fibrotic and anti-inflammatory miRNA biogenesisPrincipal Investigator

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Preservation of mammalian genetic resources and study for the developmental mechanism using freeze-dried cells

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Regulatory mechanisms of miRNA biogenesis which is involved in tumorigenesis for approach to cancer therapyPrincipal Investigator

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A novel RNA metabolism involved in cell differentiation and survival

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[Journal Article] Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis2024

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[Journal Article] YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates2021

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[Journal Article] Characteristic analysis of a secondary structure of primary microRNA bound to a double-strand RNA-binding protein, NF902021

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[Journal Article] NF90 modulates processing of a subset of human pri-miRNAs2020

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[Journal Article] Candidate plasticity gene 16 mediates suppression of insulin gene expression in rat insulinoma INS-1 cells under glucotoxic conditions.2019

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[Journal Article] A negative feedback loop between nuclear factor 90 (NF90) and an anti-oncogenic microRNA, miR-72018

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[Journal Article] An NF90/NF110-Mediated Feedback Amplification Loop Regulates DICER Expression and Controls Ovarian Carcinoma Progression.2018

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[Journal Article] A negative feedback loop between nuclear factor 90 (NF90) and an anti-oncogenic microRNA2018

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Higuchi Takuma 樋口琢磨

HIGUCHI Takuma 樋口琢磨