KAI Masaya 甲斐昌也

Researcher Number	10755242
Affiliation (based on the past Project Information) *help	2022 – 2023: 九州大学, 医学研究院, 共同研究員 2018 – 2021: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 次世代シーケンシング / 個別化治療 / 病理診断 / 人工知能による深層機械学習システム / 乳がん / 個別化医療 / 免疫染色 / 人工知能 / 乳癌 Except Principal Investigator 腫瘍微小環境 … More / scRNA-seq / heterogeneity / ネオアンチゲン / 腫瘍浸潤リンパ球（TIL） / MHCテトラマー解析 / 細胞医薬 / TIL / ペプチド / 体細胞性遺伝子変異 / ALIオルガノイド / 癌免疫微小環境 / 腫瘍内不均一性 / シングルセル解析 / オルガノイド / scRNAseq / 膵癌 / 腫瘍免疫微小環境 / 治療抵抗性 / 化学療法 / heterogeneity (不均一性) / TME (腫瘍微小環境) / NK細胞 / 食道扁平上皮癌 / 食道癌 / 空間的トランスクリプトーム解析 / 癌関連線維芽細胞 (CAF) / 腫瘍微小環境 (TME) / CAF / 大腸癌 / ペプチドがんワクチン療法 / Tumor mutational burden / 免疫チェックポイント阻害薬 / がんゲノム / 腫瘍浸潤リンパ球 / 腫瘍遺伝子変異量 / 乳癌 / 腫瘍免疫 / がん微小環境 Less

Spatial transcriptome analysis reveals CAF-induced colorectal cancer immune remodeling mechanism
- Principal Investigator
  
  SADA Masafumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Analysis of functional changes in NK cells in the TME of esophageal cancer due to chemotherapy using scRNA-seq
- Principal Investigator
  
  MORIYAMA Taiki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Analysis and remodeling of immune microenvironment using pancreatic cancer organoids after treatment
- Principal Investigator
  
  NAKAMURA Masafumi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Development of therapy-resistant breast cancer treatment using neoantigen-reactive lymphocytes
- Principal Investigator
  
  KUBO Makoto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyushu University
Construction of Breast Cancer Tissue Image Analysis Algorithm Using Deep Machine Learning System with Artificial IntelligencePrincipal Investigator
- Principal Investigator
  
  KAI Masaya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyushu University
Neoantigen analysis in tumor tissues for development of personalized precision cancer immunotherapy
- Principal Investigator
  
  KUBO Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] TP53 and/or BRCA1 Mutations Based on CtDNA Analysis as Prognostic Biomarkers for Primary Triple-Negative Breast Cancer2024
- Author(s)
  Arimura Akiko、Sakai Kazuko、Kaneshiro Kazuhisa、Morisaki Takafumi、Hayashi Saori、Mizoguchi Kimihisa、Yamada Mai、Kai Masaya、Ono Mayumi、Nishio Kazuto、Nakamura Masafumi、Kubo Makoto
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 6 Pages: 1184-1184
- DOI
  10.3390/cancers16061184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19532, KAKENHI-PROJECT-23K27468
[Journal Article] Granzyme B Expression in the Tumor Microenvironment as a Prognostic Biomarker for Patients with Triple-Negative Breast Cancer2023
- Author(s)
  Mizoguchi Kimihisa、Kawaji Hitomi、Kai Masaya、Morisaki Takafumi、Hayashi Saori、Takao Yuka、Yamada Mai、Shimazaki Akiko、Osako Tomofumi、Arima Nobuyuki、Okido Masayuki、Oda Yoshinao、Nakamura Masafumi、Kubo Makoto
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 18 Pages: 4456-4456
- DOI
  10.3390/cancers15184456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19532
[Journal Article] CCND1 Copy Number Variation in Circulating Tumor DNA from Luminal B Breast Cancer Patients2022
- Author(s)
  SHIMAZAKI AKIKO、KUBO MAKOTO、KURATA KANAKO、TAKAO YUKA、HAYASHI SAORI、HARADA YURINA、KAWAJI HITOMI、KANESHIRO KAZUHISA、YAMADA MAI、KAI MASAYA、NAKAMURA MASAFUMI
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 8 Pages: 4071-4077
- DOI
  10.21873/anticanres.15904
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19532
[Journal Article] Significance of the Multi-gene Panel myRisk in Japan2022
- Author(s)
  HAYASHI SAORI、KUBO MAKOTO、MATSUZAKI SAWAKO、KAI MASAYA、MORISAKI TAKAFUMI、YAMADA MAI、KANESHIRO KAZUHISA、TAKAO YUKA、SHIMAZAKI AKIKO、NAGAYOSHI KINUKO、MIZUUCHI YUSUKE、NAKAMURA MASAFUMI
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 8 Pages: 4097-4102
- DOI
  10.21873/anticanres.15907
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19532, KAKENHI-PROJECT-20K19173
[Journal Article] Genetic medicine is accelerating in Japan2022
- Author(s)
  Hayashi Saori、Kubo Makoto、Kaneshiro Kazuhisa、Kai Masaya、Yamada Mai、Morisaki Takafumi、Takao Yuka、Shimazaki Akiko、Shikada Sawako、Nakamura Masafumi
- Journal Title
  
  Breast Cancer
  
  Volume: 印刷中 Issue: 4 Pages: 659-665
- DOI
  10.1007/s12282-022-01342-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19532, KAKENHI-PROJECT-20K19173
[Journal Article] Validity of the prognostication tool PREDICT version 2.2 in Japanese breast cancer patients2021
- Author(s)
  Karen Zaguirre, Masaya Kai, Makoto Kubo, Mai Yamada, Kanako Kurata, Hitomi Kawaji, Kazuhisa Kaneshiro, Yurina Harada, Saori Hayashi, Akiko Shimazaki, Takafumi Morisaki, Hitomi Mori, Yoshinao Oda, Sanmei Chen, Taiki Moriyama, Shuji Shimizu, Masafumi Nakamura
- Journal Title
  
  Cancer Medicine
  
  Volume: 10 Issue: 5 Pages: 1605-1613
- DOI
  10.1002/cam4.3713
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19474, KAKENHI-PROJECT-18J20301, KAKENHI-PROJECT-18K08577
[Journal Article] Microsatellite Instability in Japanese Female Patients With Triple-Negative Breast Cancer2020
- Author(s)
  Kurata K, Kubo M, Kai M, Mori H, Kawaji H, Kaneshiro K, Yamada M, Nishimura R, Osako T, Arima N, Okido M, Oda Y, Nakamura M
- Journal Title
  
  Breast Cancer
  
  Volume: 印刷中 Issue: 3 Pages: 490-498
- DOI
  10.1007/s12282-019-01043-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08577, KAKENHI-PROJECT-18J20301
[Journal Article] Comprehensive molecular profiling broadens treatment options for breast cancer patients2020
- Author(s)
  Kawaji Hitomi、Kubo Makoto、Yamashita Nami、Yamamoto Hidetaka、Kai Masaya、Kajihara Atsuko、Yamada Mai、Kurata Kanako、Kaneshiro Kazuhisa、Harada Yurina、Hayashi Saori、Shimazaki Akiko、Mori Hitomi、Akiyoshi Sayuri、Oki Eiji、Oda Yoshinao、Baba Eishi、Mori Masaki、Nakamura Masafumi
- Journal Title
  
  Cancer Medicine
  
  Volume: 10 Issue: 2 Pages: 529-539
- DOI
  10.1002/cam4.3619
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J20301, KAKENHI-PROJECT-18K08577
[Journal Article] T-bet+ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer2019
- Author(s)
  Mori Hitomi、Kubo Makoto、Kai Masaya、Yamada Mai、Kurata Kanako、Kawaji Hitomi、Kaneshiro Kazuhisa、Osako Tomofumi、Nishimura Reiki、Arima Nobuyuki、Okido Masayuki、Kishimoto Junji、Oda Yoshinao、Nakamura Masafumi
- Journal Title
  
  Breast Cancer Research and Treatment
  
  Volume: 176 Issue: 3 Pages: 569-577
- DOI
  10.1007/s10549-019-05256-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08577, KAKENHI-PROJECT-18J20301
[Presentation] 乳癌患者とネオアンチゲン解析との関連性の検討2023
- Author(s)
  溝口公久, 森崎隆史, 甲斐昌也, 高尾由佳, 山田舞, 島﨑亜希子, 林早織, 茂地智子, 伊地知秀樹, 森崎隆, 吉住朋晴, 久保真, 中村雅史
- Organizer
  第31回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19532
[Presentation] 日本人乳癌患者の腸内細菌叢解析についての検討2023
- Author(s)
  山田舞, 久保真, 甲斐昌也, 森崎隆史, 溝口公久, 高尾由佳, 林早織, 島崎亜希子, 古賀艶可, 落合百合菜, 茂地智子, 伊地知秀樹, 吉住朋晴, 中村雅史
- Organizer
  第31回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19532
[Presentation] シングルセルRNA sequencingシークエンシングを用いたHER2陽性乳癌治療抵抗性の網羅的遺伝子解析2022
- Author(s)
  林早織, 久保真, 森瞳美, 甲斐昌也, 山田舞, 金城和寿, 森崎隆史, 高尾由佳, 島﨑亜希子, 中村雅史
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K19532
[Presentation] HBOC診療の現状と課題2022
- Author(s)
  久保真, 鹿田佐和子, 甲斐昌也, 森崎隆史, 木村緑, 小川昌宣, 加藤聖子, 水内祐介, 中村雅史
- Organizer
  第28回日本遺伝性腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19532
[Presentation] Deep Learningを用いた乳癌HE染色画像解析2021
- Author(s)
  原田由利菜, 中津川宗秀, 久保真, 甲斐昌也, 山田舞, 森瞳美, 川地眸, 金城和寿, 林早織, 島﨑亜希子, 森崎隆史, 岩崎健, 山元英崇, 小田義直, 中村雅史
- Organizer
  第57回九州外科学会
- Data Source
  KAKENHI-PROJECT-20K07637
[Presentation] Deep Learning を用いた乳癌 HE 染色画像解析とタンパク発現予測に関する研究2021
- Author(s)
  原田由利菜, 中津川宗秀, 久保真, 甲斐昌也, 山田舞, 森瞳美, 川地眸, 金城和寿, 林早織, 島﨑亜希子, 森崎隆史, 岩崎健, 山元英崇, 小田義直, 中村雅史
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K07637
[Presentation] 乳癌におけるネオアンチゲン解析の有用性2020
- Author(s)
  久保真, 森崎隆史, 甲斐昌也, 梅林雅代, 島﨑亜希子, 林早織, 原田由利菜, 川地眸, 金城和寿, 倉田加奈子, 森瞳美, 山田舞, 森崎隆, 中村雅史
- Organizer
  第28回日本乳癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] Precision Oncology：乳がんゲノムプロファイリングから見えてきたこと2020
- Author(s)
  久保真, 甲斐昌也, 山田舞, 中村雅史
- Organizer
  第26回日本遺伝性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] マルチプレックス遺伝子パネルFoundationOne CDxが変えるHER2陽性乳癌の周術期治療2020
- Author(s)
  久保真, 川地眸, 甲斐昌也, 山田舞, 倉田加奈子, 森瞳美, 金城和寿, 本山由利菜, 林早織, 島﨑亜希子, 森崎隆史, 沖英次, 中村雅史
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] Deep Learningを用いた乳癌HE染色画像解析とタンパク発現予測に関する研究2020
- Author(s)
  原田由利菜, 久保真, 甲斐昌也, 山田舞, 森瞳美, 倉田加奈子, 川地眸, 金城和寿, 林早織, 島﨑亜希子, 森崎隆史, 小田義直, 中津川宗秀, 中村雅史,
- Organizer
  第28回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07637
[Presentation] Tumor Mutational Burden in Japanese Patients with Triple Negative Breast Cancer2019
- Author(s)
  Kurata K, Kubo M, Yuan Y, Harada Y, Morisaki T, Shimazaki A, Hayashi S, Kawaji H, Kaneshiro K, Yamada M, Kai M, Nakamura M
- Organizer
  The 42nd San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] A prospective evaluation of comprehensive tumor profiling busing a targeted Next-generation sequencing for Japanese breast cancer patients2019
- Author(s)
  Kawaji H, Kubo M, Yamashita N, Harada Y, Shimazaki A, Hayashi S, Kurata K, Yamada M, Kaneshiro K, Kai M, Babe E, Oda Y, Nakamura M
- Organizer
  The 42nd San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] 乳癌におけるネオアンチゲン解析の意義2019
- Author(s)
  森崎隆史、久保真、梅林雅代、吉村祥子、川地眸、倉田加奈子、金城和寿、森瞳、山田舞、林早織、本山由利菜、甲斐昌也、中村雅史、森崎隆
- Organizer
  第32回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] PD-L1 expression of tumor infiltrating immune cells has potential as a biomarker in triple-negative breast cancers2019
- Author(s)
  Harada Y, Kubo M, Mori H, Kai M, Yamada M, Kurata K, Kawaji H, Kaneshiro K, Hayashi S, Shimazaki A, Morisaki T, Yamaguchi R, Arima N, Nishimura R, Okido M, Nakamura M
- Organizer
  The 42nd San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] Microsatellite Instability in Triple Negative Breast Cancers2018
- Author(s)
  Kanako Kurata, Makoto Kubo, Hitomi Mori, Hitomi Kawaji, Yurina Motoyama, Lumi Kuroki, Mai Yamada, Kazuhisa Kaneshiro, Masaya Kai, Masafumi Nakamura
- Organizer
  The 2018 San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08577
[Presentation] Transcription factor T-bet and PD-L1 expression in tumor microenvironment of triple-negative breast cancer2018
- Author(s)
  Hitomi Mori, Makoto Kubo, Masaya Kai, Kanako Kurata, Hitomi Kawaji, Kazuhisa Kaneshiro, Yurina Motoyama, Rumi Kuroki, Mai Yamada, Reiki Nishimura, Masayuki Okido, Yoshinao Oda, Masafumi Nakamura
- Organizer
  The 2018 San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08577

1. KUBO Makoto (60403961)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. NAKAMURA Masafumi (30372741)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. 森崎隆 (90291517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. SADA Masafumi (10783508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MORIYAMA Taiki (70586859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大内田研宙 (20452708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大西秀哉 (30553276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 水元一博 (90253418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小田義直 (70291515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 中津川宗秀 (70448596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 藤田逸人 (40611281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三好圭 (70755272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小薗真吾 (40706850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森瞳美 (70795541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. 井手野昇 (90883421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 陳三妹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAI Masaya 甲斐 昌也

Research Projects

Research Products

Co-Researchers

Spatial transcriptome analysis reveals CAF-induced colorectal cancer immune remodeling mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of functional changes in NK cells in the TME of esophageal cancer due to chemotherapy using scRNA-seq

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis and remodeling of immune microenvironment using pancreatic cancer organoids after treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapy-resistant breast cancer treatment using neoantigen-reactive lymphocytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of Breast Cancer Tissue Image Analysis Algorithm Using Deep Machine Learning System with Artificial IntelligencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Neoantigen analysis in tumor tissues for development of personalized precision cancer immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] TP53 and/or BRCA1 Mutations Based on CtDNA Analysis as Prognostic Biomarkers for Primary Triple-Negative Breast Cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Granzyme B Expression in the Tumor Microenvironment as a Prognostic Biomarker for Patients with Triple-Negative Breast Cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCND1 Copy Number Variation in Circulating Tumor DNA from Luminal B Breast Cancer Patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significance of the Multi-gene Panel myRisk in Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic medicine is accelerating in Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Validity of the prognostication tool PREDICT version 2.2 in Japanese breast cancer patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microsatellite Instability in Japanese Female Patients With Triple-Negative Breast Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive molecular profiling broadens treatment options for breast cancer patients2020

Author(s)

Journal Title

DOI

Data Source

KAI Masaya 甲斐昌也