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Kojima Ryosuke  小嶋 良輔

ORCIDConnect your ORCID iD *help
Researcher Number 10808059
Other IDs
Affiliation (Current) 2025: 東京大学, 大学院医学系研究科(医学部), 准教授
Affiliation (based on the past Project Information) *help 2022 – 2025: 東京大学, 大学院医学系研究科(医学部), 准教授
2020 – 2022: 東京大学, 大学院医学系研究科(医学部), 助教
Review Section/Research Field
Principal Investigator
Basic Section 37030:Chemical biology-related / Transformative Research Areas, Section (III)
Except Principal Investigator
Transformative Research Areas, Section (II) / Medium-sized Section 90:Biomedical engineering and related fields / Transformative Research Areas, Section (III) / Biological Sciences
Keywords
Principal Investigator
がん / 蛍光プローブ / バーコード / 細胞外小胞 / 合成生物学 / 細胞間コミュニケーション / プロドラッグ / 酵素センサー / 機能性蛋白質 / がんイメージング … More / イメージング / 蛍光イメージング / 機能性小分子 / 機能性タンパク質 … More
Except Principal Investigator
ラマンイメージング / 多重検出 / ラマンプローブ / ポイントオブケア / リキッドアセスメント / 難治性創傷 / 低周波振動 / 細胞老化 / 創傷ドレッシング / 看護理工学 / 細胞間相互作用 / 細胞動態計測 / 細胞多様性 / 環境適応 / リソソーム / ホスホリパーゼ / オートファジー / 細胞小器官 / 生体膜 / 細胞内分解 / 機能性小分子 Less
  • Research Projects

    (8 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (20 People)
  •  Development of reporter enzymes that are activated by antigen recognition and their application for imaging and treatment of cancer cellsPrincipal Investigator

    • Principal Investigator
      小嶋 良輔
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      The University of Tokyo
  •  「適応多様性」研究領域の拡大・発展に向けた総括研究

    • Principal Investigator
      諸石 寿朗
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Institute of Science Tokyo
      Kumamoto University
  •  Understanding "adaptive diversity" based on comprehensive recording of intercellular communicationPrincipal Investigator

    • Principal Investigator
      小嶋 良輔
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokyo
  •  Selective wound healing senolytics targeting senescent cells in wound exudate

    • Principal Investigator
      仲上 豪二朗
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      The University of Tokyo
  •  Research on intracellular degradation focusing on membranous structures

    • Principal Investigator
      水島 昇
    • Project Period (FY)
      2022 – 2027
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Novel methods of fluorescence cancer imaging by utilizing combination of functional small molecules and proteinsPrincipal Investigator

    • Principal Investigator
      Kojima Ryosuke
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      The University of Tokyo
  •  Innovative multiplex imaging with functional Raman probes

    • Principal Investigator
      Kamiya Mako
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Tokyo Institute of Technology
      The University of Tokyo
  •  Development of functional Raman probes for innovative multiplex imaging

    • Principal Investigator
      Kamiya Mako
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Tokyo Institute of Technology
      The University of Tokyo

All 2023 2022 2021 2020

All Journal Article Presentation Book Patent

  • [Book] Methods in Molecular Biology, Mammalian Cell Engineering2021

    • Author(s)
      Ryosuke Kojima
    • Total Pages
      330
    • Publisher
      Springer Nature
    • ISBN
      9781071614419
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Journal Article] Rapid imaging of thymoma and thymic carcinoma with a fluorogenic probe targeting γ-glutamyltranspeptidase2023

    • Author(s)
      Yoshida Daisuke、Kamiya Mako、Kawashima Shun、Yoshioka Takafusa、Hino Haruaki、Abe Atsuki、Fujita Kyohhei、Kojima Ryosuke、Shinozaki-Ushiku Aya、Urano Yasuteru、Nakajima Jun
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 3757-3757

    • DOI

      10.1038/s41598-023-30753-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-23K23460
  • [Journal Article] Activatable Raman Probes Utilizing Enzyme-Induced Aggregate Formation for Selective Ex Vivo Imaging2023

    • Author(s)
      Fujioka Hiroyoshi、Kawatani Minoru、Spratt Spencer John、Komazawa Ayumi、Misawa Yoshihiro、Shou Jingwen、Mizuguchi Takaha、Kosakamoto Hina、Kojima Ryosuke、Urano Yasuteru、Obata Fumiaki、Ozeki Yasuyuki、Kamiya Mako
    • Journal Title

      Journal of the American Chemical Society

      Volume: 145 Issue: 16 Pages: 8871-8881

    • DOI

      10.1021/jacs.2c12381

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05724, KAKENHI-PLANNED-20H05725, KAKENHI-PLANNED-20H05726, KAKENHI-PROJECT-22KJ0628
  • [Journal Article] 9‐Cyano‐10‐telluriumpyronin Derivatives as Red‐light‐activatable Raman Probes2023

    • Author(s)
      Kawatani Minoru、Spratt Spencer J.、Fujioka Hiroyoshi、Shou Jingwen、Misawa Yoshihiro、Kojima Ryosuke、Urano Yasuteru、Ozeki Yasuyuki、Kamiya Mako
    • Journal Title

      Chemistry An Asian Journal

      Volume: 18 Issue: 2

    • DOI

      10.1002/asia.202201086

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05724, KAKENHI-PLANNED-20H05725, KAKENHI-PROJECT-20H02874
  • [Journal Article] Rapid imaging of lung cancer using a red fluorescent probe to detect dipeptidyl peptidase 4 and puromycin-sensitive aminopeptidase activities2022

    • Author(s)
      Kawashima Shun、Yoshida Daisuke、Yoshioka Takafusa、Ogasawara Akira、Fujita Kyohhei、Yanagiya Masahiro、Nagano Masaaki、Konoeda Chihiro、Hino Haruaki、Kitano Kentaro、Sato Masaaki、Hino Rumi、Kojima Ryosuke、Komatsu Toru、Kamiya Mako、Urano Yasuteru、Nakajima Jun
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 12665-9

    • DOI

      10.1038/s41598-022-12665-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08586, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-23K23460, KAKENHI-PROJECT-23K23484
  • [Journal Article] Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities2022

    • Author(s)
      Kuriki Yugo、Yoshioka Takafusa、Kamiya Mako、Komatsu Toru、Takamaru Hiroyuki、Fujita Kyohhei、Iwaki Hirohisa、Nanjo Aika、Akagi Yuki、Takeshita Kohei、Hino Haruaki、Hino Rumi、Kojima Ryosuke、Ueno Tasuku、Hanaoka Kenjiro、Abe Seiichiro、Saito Yutaka、Nakajima Jun、Urano Yasuteru
    • Journal Title

      Chemical Science

      Volume: 13 Issue: 16 Pages: 4474-4481

    • DOI

      10.1039/d1sc06889j

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-21H05262, KAKENHI-PROJECT-19H02826, KAKENHI-PROJECT-20H02701, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-21K08586, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-22KJ1177, KAKENHI-PROJECT-23K23484
  • [Journal Article] Measuring the pH of Acidic Vesicles in Live Cells with an Optimized Fluorescence Lifetime Imaging Probe2022

    • Author(s)
      Koda Kinuko、Keller Sascha、Kojima Ryosuke、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Analytical Chemistry

      Volume: 94 Issue: 32 Pages: 11264-11271

    • DOI

      10.1021/acs.analchem.2c01840

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-23K23460
  • [Journal Article] Fluorescence Probes for Imaging Basic Carboxypeptidase Activity in Living Cells with High Intracellular Retention2021

    • Author(s)
      Iwaki Hirohisa、Kamiya Mako、Kawatani Minoru、Kojima Ryosuke、Yamasoba Tatsuya、Urano Yasuteru
    • Journal Title

      Analytical Chemistry

      Volume: 93 Issue: 7 Pages: 3470-3476

    • DOI

      10.1021/acs.analchem.0c04793

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20H05724, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874
  • [Journal Article] Intracellular Unnatural Catalysis Enabled by an Artificial Metalloenzyme2021

    • Author(s)
      Yasunori Okamoto, Ryosuke Kojima
    • Journal Title

      Methods in Molecular Biology

      Volume: 2312 Pages: 287-300

    • DOI

      10.1007/978-1-0716-1441-9_17

    • ISBN
      9781071614402, 9781071614419
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Journal Article] Photoactivatable fluorophores for durable labelling of individual cells2021

    • Author(s)
      Kashima Hiroki、Kamiya Mako、Obata Fumiaki、Kojima Ryosuke、Nakano Shotaro、Miura Masayuki、Urano Yasuteru
    • Journal Title

      Chemical Communications

      Volume: 57 Issue: 47 Pages: 5802-5805

    • DOI

      10.1039/d1cc01488a

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20H05724, KAKENHI-PLANNED-20H05726, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874
  • [Journal Article] Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging2020

    • Author(s)
      Morozumi Akihiko、Kamiya Mako、Uno Shin-nosuke、Umezawa Keitaro、Kojima Ryosuke、Yoshihara Toshitada、Tobita Seiji、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: - Pages: 9625-9633

    • DOI

      10.1021/jacs.0c00451

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-15H05951, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-18H03509, KAKENHI-PROJECT-19H02826, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19K22947
  • [Journal Article] ?-glutamyl hydroxymethyl rhodamine green fluorescence as a prognostic indicator for lung cancer2020

    • Author(s)
      Kawashima Shun、Yoshioka Takafusa、Hino Haruaki、Kitano Kentaro、Nagayama Kazuhiro、Sato Masaaki、Kojima Ryosuke、Kamiya Mako、Urano Yasuteru、Nakajima Jun
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 68 Issue: 12 Pages: 1418-1424

    • DOI

      10.1007/s11748-020-01395-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874
  • [Journal Article] Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations2020

    • Author(s)
      Tachibana Ryo、Kamiya Mako、Morozumi Akihiko、Miyazaki Yoshiyuki、Fujioka Hiroyoshi、Nanjo Aika、Kojima Ryosuke、Komatsu Toru、Ueno Tasuku、Hanaoka Kenjiro、Yoshihara Toshitada、Tobita Seiji、Urano Yasuteru
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 86 Pages: 13173-13176

    • DOI

      10.1039/d0cc05126h

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-18H03509, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19K22947
  • [Journal Article] Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities2020

    • Author(s)
      Fujioka Hiroyoshi、Shou Jingwen、Kojima Ryosuke、Urano Yasuteru、Ozeki Yasuyuki、Kamiya Mako
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 49 Pages: 20701-20707

    • DOI

      10.1021/jacs.0c09200

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-20H05724, KAKENHI-PLANNED-20H05725, KAKENHI-PROJECT-20H02650, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19J22546
  • [Journal Article] Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α-Mannosidase 2C12020

    • Author(s)
      Fujita Kyohhei、Kamiya Mako、Yoshioka Takafusa、Ogasawara Akira、Hino Rumi、Kojima Ryosuke、Ueo Hiroaki、Urano Yasuteru
    • Journal Title

      ACS Central Science

      Volume: 6 Issue: 12 Pages: 2217-2227

    • DOI

      10.1021/acscentsci.0c01189

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-19H02826, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19J21205
  • [Journal Article] γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging2020

    • Author(s)
      Obara Rui、Kamiya Mako、Tanaka Yoko、Abe Atsuki、Kojima Ryosuke、Kawaguchi Tokuichi、Sugawara Minoru、Takahashi Akiko、Noda Tetsuo、Urano Yasuteru
    • Journal Title

      Angewandte Chemie

      Volume: 133 Issue: 4 Pages: 2153-2157

    • DOI

      10.1002/ange.202013265

    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Patent] 特殊な活性を持つβ-Glucosidase Td2F2の変異体2022

    • Inventor(s)
      小嶋良輔・王子儀・浦野泰照
    • Industrial Property Rights Holder
      小嶋良輔・王子儀・浦野泰照
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] 機能性タンパク質と小分子の複合的利用による抗原可視化の新手法2023

    • Author(s)
      小嶋良輔
    • Organizer
      第74回日本電気泳動学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] 抗原認識タンパク質上に導入した蛍光団のスピロ環化制御による新規抗原検出法の開発2023

    • Author(s)
      清家直樹、小嶋良輔、浦野泰照
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] 高感度・低バックグランドながんイメージングを可能とするbio-orthogonalな蛍光プローブ・改変レポーター酵素ペア2023

    • Author(s)
      王子儀、小嶋良輔、藤田恭平、浦野泰照
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] 機能性タンパク質・小分子の協奏利用による新規がん蛍光イメージング技術の開発2022

    • Author(s)
      小嶋良輔、中館眞美子、王子儀、浦野泰照
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] 生体直交性を有する蛍光プローブ・改変酵素ペアを用いた新規がんイメージング手法の開発2022

    • Author(s)
      王子儀、小嶋良輔、浦野泰照
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] Bio-orthogonalな蛍光プローブ・改変酵素ペアを活用したがんイメージングの新手法2022

    • Author(s)
      王子儀、小嶋良輔、藤田恭平、浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会 第16回年会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] 新たな先端医療創製を目指したものづくり ~機能性小分子の開発から、細胞機能の自在プログラミングまで~2021

    • Author(s)
      小嶋良輔
    • Organizer
      MPUFセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] 抗原結合を検知する新規activatable型蛍光プローブの開発2021

    • Author(s)
      中館眞美子、小嶋良輔、浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会 第15回年会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] HFSPを用いたスイス留学と,帰国後の研究立ち上げの事例2020

    • Author(s)
      小嶋良輔
    • Organizer
      RA協議会2020
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] バーコード化EVが可能とするEV研究の新展開2020

    • Author(s)
      小嶋良輔
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] “異分野融合”を形にするには何が必要なのだろうか ~SXRをミッション脱出のためのプロジェクト考案だけで終わらせないために~2020

    • Author(s)
      小嶋良輔
    • Organizer
      The 1st Scienc-ome XR Innovation Hub
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] スーパー細ヤ胞をつくる2020

    • Author(s)
      小嶋良輔
    • Organizer
      8th Scienc-ome
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] Designer Cellを用いた新たな疾患治療システムとその設計原理2020

    • Author(s)
      小嶋良輔
    • Organizer
      第93回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H02874
  • [Presentation] Development of a Novel Bio-orthogonal Probe - Reporter Enzyme Pair for Fluorescence Cancer Imaging2020

    • Author(s)
      Wang Ziyi, Ryosuke Kojima, Yasuteru Urano
    • Organizer
      第14回日本分子イメージング学会
    • Data Source
      KAKENHI-PROJECT-20H02874
  • 1.  Kamiya Mako (90596462)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 2.  小幡 史明 (40748539)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  小関 泰之 (60437374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  水島 昇 (10353434)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  塚本 智史 (80510693)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  森下 英晃 (90783499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  諸石 寿朗 (30647722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  谷内江 望 (60636801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  井上 大地 (80735746)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  仲上 豪二朗 (70547827)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  真田 弘美 (50143920)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  酒井 崇匡 (70456151)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  野村 征太郎 (10722118)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  峰松 健夫 (00398752)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  秋下 雅弘 (00261975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  佐久間 一郎 (50178597)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HINO Rumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  浦野 泰照
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 19.  花岡 健二郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  小松 徹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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