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Moroishi Toshiro  諸石 寿朗

ORCIDConnect your ORCID iD *help
Researcher Number 30647722
Other IDs
Affiliation (Current) 2022: 熊本大学, 大学院生命科学研究部(医), 教授
Affiliation (based on the past Project Information) *help 2019 – 2022: 熊本大学, 大学院生命科学研究部(医), 教授
2018: 熊本大学, 大学院生命科学研究部(医), 准教授
Review Section/Research Field
Principal Investigator
Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 44010:Cell biology-related / Basic Section 50010:Tumor biology-related / Transformative Research Areas, Section (III)
Except Principal Investigator
Basic Section 55020:Digestive surgery-related
Keywords
Principal Investigator
鉄代謝 / Hippoシグナル / 免疫 / ゲノム編集 / ライブラリースクリーニング / シグナル伝達経路 / ユビキチン / 免疫応答 / 免疫原性 / 自己免疫疾患 … More / Hippo経路 / がん / 腫瘍微小環境 / 代謝競合 / 器官形成 / 体外胚培養 / 組織の自律性 … More
Except Principal Investigator
腸内細菌叢 / 食道癌 / 腫瘍免疫 / 腸内細菌 / Fusobacterium nucleatum / NFKB / Microbiome, Less
  • Research Projects

    (5 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (18 People)
  •  体外胚培養システムの構築による哺乳類器官形成期の組織自律性の解明Principal Investigator

    • Principal Investigator
      諸石 寿朗
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kumamoto University
  •  腫瘍微小環境における鉄代謝の役割解明Principal Investigator

    • Principal Investigator
      諸石 寿朗
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kumamoto University
  •  革新的治療開発を目指した腸内細菌Fusobacteriumと腫瘍免疫の網羅的解析

    • Principal Investigator
      馬場 祥史
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Kumamoto University
  •  Towards an understanding of iron metabolism: comprehensive identification of iron-related moleculesPrincipal Investigator

    • Principal Investigator
      Moroishi Toshiro
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Kumamoto University
  •  Elucidating the regulatory mechanisms and physiological functions of immunomodulation by the Hippo intracellular signaling pathwayPrincipal Investigator

    • Principal Investigator
      Moroishi Toshiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Kumamoto University

All 2020 2019 2018

All Journal Article Presentation

  • [Journal Article] The Emerging Link between the Hippo Pathway and Non-coding RNA2020

    • Author(s)
      Shimoda Mayuko、Moroishi Toshiro
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 43 Issue: 1 Pages: 1-10

    • DOI

      10.1248/bpb.b19-00795

    • NAID

      130007779182

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Journal Article] Heat stress activates YAP/TAZ to induce the heat shock transcriptome2020

    • Author(s)
      Luo Min、Meng Zhipeng、Moroishi Toshiro、Lin Kimberly C.、Shen Guobo、Mo Fei、Shao Bin、Wei Xiawei、Zhang Ping、Wei Yuquan、Guan Kun-Liang
    • Journal Title

      Nature Cell Biology

      Volume: 22 Pages: 1447-1459

    • DOI

      10.1038/s41556-020-00602-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Journal Article] The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity2020

    • Author(s)
      Yamauchi Takayoshi、Moroishi Toshiro
    • Journal Title

      The Journal of Biochemistry

      Volume: 169 Pages: 155-161

    • DOI

      10.1093/jb/mvaa132

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Journal Article] BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling2019

    • Author(s)
      Verma, S., Yeddula, N., Soda, Y., Zhu, Q., Pao, G.M., Moresco, J., Diedrich, J.K., Hong, A., Plouffe, S., Moroishi, T., Guan, K.L., and Verma, I.M.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Pages: 7363-7370

    • DOI

      10.1073/pnas.1822155116

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Journal Article] Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.2019

    • Author(s)
      Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
    • Journal Title

      J. Exp. Med.

      Volume: 216 Issue: 4 Pages: 950-965

    • DOI

      10.1084/jem.20180900

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19433, KAKENHI-PROJECT-18K19509, KAKENHI-PUBLICLY-17H05953, KAKENHI-PROJECT-18H02747, KAKENHI-PROJECT-16K07177, KAKENHI-PROJECT-17K19608, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K20403, KAKENHI-PROJECT-18H05215, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-19H03715
  • [Journal Article] Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α-Mannose as Adjuvants2019

    • Author(s)
      Shinchi Hiroyuki、Yamaguchi Toru、Moroishi Toshiro、Yuki Masaharu、Wakao Masahiro、Cottam Howard B.、Hayashi Tomoko、Carson Dennis A.、Suda Yasuo
    • Journal Title

      Bioconjugate Chemistry

      Volume: 30 Pages: 2811-2821

    • DOI

      10.1021/acs.bioconjchem.9b00560

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438, KAKENHI-PROJECT-17K17968, KAKENHI-PROJECT-19H00929
  • [Journal Article] Regulation of mitochondrial iron homeostasis by sideroflexin 22019

    • Author(s)
      Non, E.E., *Wei, F.-Y., Ahmad, R.N.R., Yamamoto, T., Moroishi. T., *Tomizawa, K.
    • Journal Title

      J. Physiol. Sci.

      Volume: 69 Pages: 359-373

    • DOI

      10.1007/s12576-018-0652-2

    • NAID

      40021819064

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17KT0054, KAKENHI-PROJECT-18K19433, KAKENHI-PROJECT-18K19521, KAKENHI-PROJECT-18H02865, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H02599
  • [Journal Article] Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity2019

    • Author(s)
      Horiguchi H, Kadomatsu T, Kurahashi R, Hara C, Miyata K, Baba M, Osumi H, Terada K, Araki K, Takai T, Kamba T, Linehan WM, Moroishi T, Oike Y.
    • Journal Title

      Genes Dev.

      Volume: 33 Pages: 1641-1656

    • DOI

      10.1101/gad.329417.119

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07236, KAKENHI-PROJECT-19K08560, KAKENHI-PROJECT-18H02438, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-18K19619, KAKENHI-PROJECT-18K15246
  • [Journal Article] Hippo Pathway in Mammalian Adaptive Immune System2019

    • Author(s)
      Yamauchi, T., Moroishi, T.
    • Journal Title

      Cells

      Volume: 8 Pages: 398-398

    • DOI

      10.3390/cells8050398

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Journal Article] Cell type-dependent function of LATS1/2 in cancer cell growth2018

    • Author(s)
      Pan, W.W., Moroishi, T., Koo,J.H., and Guan, K.L.
    • Journal Title

      Oncogene

      Volume: 38 Pages: 2595-2610

    • DOI

      10.1038/s41388-018-0610-8

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Journal Article] Assembly and activation of the Hippo signalome by FAT1 tumor suppressor2018

    • Author(s)
      Martin, D., Degese, M.S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J.L.C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., Thorne, R.F., Zaida, M., Siegele, B., Cheong, S.C., Molinolo, A.A., Samuels, Y., Tamayo, P., Guan, K.L., Lippman, S.M., Lyons, J.G., and Gutkind, J.S.
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 2372-2372

    • DOI

      10.1038/s41467-018-04590-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Journal Article] RAP2 mediates mechanoresponses of the Hippo pathway2018

    • Author(s)
      Meng, Z., Qiu, Y., Lin, K.C., Kumar, A., Placone, J.K., Fang, C., Wang, K.C., Lu, S., Pan, M., Hong, A.W., Moroishi, T., Luo, M., Plouffe, S.W., Diao, Y., Ye, Z., Park, H.W., Wang, X., Yu, F.X., Chien, S., Wang, C.Y., Ren, B., Engler, A.J., and Guan, K.L.
    • Journal Title

      Nature

      Volume: 560 Pages: 655-660

    • DOI

      10.1038/s41586-018-0444-0

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Presentation] Regulation of anti-tumor immunity by extracellular vesicles and the Hippo pathway2020

    • Author(s)
      諸石寿朗
    • Organizer
      第93回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Presentation] がん細胞内のシグナルと細胞外小胞による腫瘍微小環境の制御2020

    • Author(s)
      諸石寿朗
    • Organizer
      第24回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Presentation] 細胞外小胞による免疫応答の制御2019

    • Author(s)
      諸石寿朗
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Presentation] The Hippo pathway in cancer and immunity2019

    • Author(s)
      Toshiro Moroishi
    • Organizer
      TFC International Symposium: Cancer Etiology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Presentation] Hippo経路と細胞外小胞によるがん免疫の制御2018

    • Author(s)
      諸石寿朗
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18H02438
  • [Presentation] Targeting the Hippo intracellular signaling pathway for cancer immunotherapy2018

    • Author(s)
      Moroishi, T.
    • Organizer
      THE 45th NAITO CONFERENCE: Immunological and Molecular Bases for Cancer Immunotherapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02438
  • 1.  馬場 祥史 (20599708)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  馬場 秀夫 (20240905)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  澤 智裕 (30284756)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  MIMORI KOSHI
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  KADOMATSU Tsuyoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  西山 正章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  江口 英利
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  中山 啓子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  中山 敬一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  森 正樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  新地 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  隅田 泰生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  富澤 一仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  魏 范研
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  宮田 敬士
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  神波 大己
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  馬場 理也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  堀口 晴紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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