Kojima Ryosuke 小嶋良輔

Researcher Number	10808059
Other IDs
Affiliation (Current)	2023: 東京大学, 大学院医学系研究科(医学部), 准教授
Affiliation (based on the past Project Information) *help	2023: 東京大学, 大学院医学系研究科(医学部), 准教授 2020 – 2022: 東京大学, 大学院医学系研究科(医学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related Except Principal Investigator Transformative Research Areas, Section (II) / Medium-sized Section 90:Biomedical engineering and related fields / Biological Sciences
Keywords	Principal Investigator 機能性蛋白質 / がんイメージング / 機能性小分子 / 蛍光イメージング / イメージング / がん / 機能性タンパク質 / 蛍光プローブ Except Principal Investigator ラマンプローブ / 多重検出 … More / ラマンイメージング / ポイントオブケア / リキッドアセスメント / 細胞老化 / 創傷ドレッシング / 看護理工学 / 機能性小分子 / ホスホリパーゼ / オートファジー / 細胞小器官 / 生体膜 / 細胞内分解 Less

Selective wound healing senolytics targeting senescent cells in wound exudate
- Principal Investigator
  
  仲上豪二朗
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Research on intracellular degradation focusing on membranous structures
- Principal Investigator
  
  水島昇
- Project Period (FY)
  2022 – 2027
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Novel methods of fluorescence cancer imaging by utilizing combination of functional small molecules and proteinsPrincipal Investigator
- Principal Investigator
  
  小嶋良輔
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  The University of Tokyo
Innovative multiplex imaging with functional Raman probes
- Principal Investigator
  
  神谷真子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Tokyo Institute of Technology
  The University of Tokyo
Development of functional Raman probes for innovative multiplex imaging
- Principal Investigator
  
  神谷真子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Tokyo Institute of Technology
  The University of Tokyo

All 2022 2021 2020

All Journal Article Presentation Book Patent

[Book] Methods in Molecular Biology, Mammalian Cell Engineering2021
- Author(s)
  Ryosuke Kojima
- Total Pages
  330
- Publisher
  Springer Nature
- ISBN
  9781071614419
- Data Source
  KAKENHI-PROJECT-20H02874
[Journal Article] Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities2022
- Author(s)
  Kuriki Yugo、Yoshioka Takafusa、Kamiya Mako、Komatsu Toru、Takamaru Hiroyuki、Fujita Kyohhei、Iwaki Hirohisa、Nanjo Aika、Akagi Yuki、Takeshita Kohei、Hino Haruaki、Hino Rumi、Kojima Ryosuke、Ueno Tasuku、Hanaoka Kenjiro、Abe Seiichiro、Saito Yutaka、Nakajima Jun、Urano Yasuteru
- Journal Title
  
  Chemical Science
  
  Volume: 13 Issue: 16 Pages: 4474-4481
- DOI
  10.1039/d1sc06889j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05262, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-19H02826, KAKENHI-PROJECT-20H02701, KAKENHI-PROJECT-20H02874
[Journal Article] Fluorescence Probes for Imaging Basic Carboxypeptidase Activity in Living Cells with High Intracellular Retention2021
- Author(s)
  Iwaki Hirohisa、Kamiya Mako、Kawatani Minoru、Kojima Ryosuke、Yamasoba Tatsuya、Urano Yasuteru
- Journal Title
  
  Analytical Chemistry
  
  Volume: 93 Issue: 7 Pages: 3470-3476
- DOI
  10.1021/acs.analchem.0c04793
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20H05724, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874
[Journal Article] Intracellular Unnatural Catalysis Enabled by an Artificial Metalloenzyme2021
- Author(s)
  Yasunori Okamoto, Ryosuke Kojima
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2312 Pages: 287-300
- DOI
  10.1007/978-1-0716-1441-9_17
- ISBN
  9781071614402, 9781071614419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02874
[Journal Article] Photoactivatable fluorophores for durable labelling of individual cells2021
- Author(s)
  Kashima Hiroki、Kamiya Mako、Obata Fumiaki、Kojima Ryosuke、Nakano Shotaro、Miura Masayuki、Urano Yasuteru
- Journal Title
  
  Chemical Communications
  
  Volume: 57 Issue: 47 Pages: 5802-5805
- DOI
  10.1039/d1cc01488a
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20H05724, KAKENHI-PLANNED-20H05726, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874
[Journal Article] Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging2020
- Author(s)
  Morozumi Akihiko、Kamiya Mako、Uno Shin-nosuke、Umezawa Keitaro、Kojima Ryosuke、Yoshihara Toshitada、Tobita Seiji、Urano Yasuteru
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: - Pages: 9625-9633
- DOI
  10.1021/jacs.0c00451
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05951, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-18H03509, KAKENHI-PROJECT-19H02826, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19K22947
[Journal Article] ?-glutamyl hydroxymethyl rhodamine green fluorescence as a prognostic indicator for lung cancer2020
- Author(s)
  Kawashima Shun、Yoshioka Takafusa、Hino Haruaki、Kitano Kentaro、Nagayama Kazuhiro、Sato Masaaki、Kojima Ryosuke、Kamiya Mako、Urano Yasuteru、Nakajima Jun
- Journal Title
  
  General Thoracic and Cardiovascular Surgery
  
  Volume: 68 Issue: 12 Pages: 1418-1424
- DOI
  10.1007/s11748-020-01395-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-20H02874
[Journal Article] Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations2020
- Author(s)
  Tachibana Ryo、Kamiya Mako、Morozumi Akihiko、Miyazaki Yoshiyuki、Fujioka Hiroyoshi、Nanjo Aika、Kojima Ryosuke、Komatsu Toru、Ueno Tasuku、Hanaoka Kenjiro、Yoshihara Toshitada、Tobita Seiji、Urano Yasuteru
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 86 Pages: 13173-13176
- DOI
  10.1039/d0cc05126h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-18H03509, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19K22947
[Journal Article] Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities2020
- Author(s)
  Fujioka Hiroyoshi、Shou Jingwen、Kojima Ryosuke、Urano Yasuteru、Ozeki Yasuyuki、Kamiya Mako
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 49 Pages: 20701-20707
- DOI
  10.1021/jacs.0c09200
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05724, KAKENHI-PLANNED-20H05725, KAKENHI-PROJECT-20H02650, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19J22546
[Journal Article] Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α-Mannosidase 2C12020
- Author(s)
  Fujita Kyohhei、Kamiya Mako、Yoshioka Takafusa、Ogasawara Akira、Hino Rumi、Kojima Ryosuke、Ueo Hiroaki、Urano Yasuteru
- Journal Title
  
  ACS Central Science
  
  Volume: 6 Issue: 12 Pages: 2217-2227
- DOI
  10.1021/acscentsci.0c01189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-19H02826, KAKENHI-PROJECT-20H02874, KAKENHI-PROJECT-19J21205
[Journal Article] γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging2020
- Author(s)
  Obara Rui、Kamiya Mako、Tanaka Yoko、Abe Atsuki、Kojima Ryosuke、Kawaguchi Tokuichi、Sugawara Minoru、Takahashi Akiko、Noda Tetsuo、Urano Yasuteru
- Journal Title
  
  Angewandte Chemie
  
  Volume: 133 Issue: 4 Pages: 2153-2157
- DOI
  10.1002/ange.202013265
- Data Source
  KAKENHI-PROJECT-20H02874
[Patent] 特殊な活性を持つβ-Glucosidase Td2F2の変異体2022
- Inventor(s)
  小嶋良輔・王子儀・浦野泰照
- Industrial Property Rights Holder
  小嶋良輔・王子儀・浦野泰照
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] 機能性タンパク質・小分子の協奏利用による新規がん蛍光イメージング技術の開発2022
- Author(s)
  小嶋良輔、中館眞美子、王子儀、浦野泰照
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] 生体直交性を有する蛍光プローブ・改変酵素ペアを用いた新規がんイメージング手法の開発2022
- Author(s)
  王子儀、小嶋良輔、浦野泰照
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] 新たな先端医療創製を目指したものづくり　～機能性小分子の開発から、細胞機能の自在プログラミングまで～2021
- Author(s)
  小嶋良輔
- Organizer
  MPUFセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] 抗原結合を検知する新規activatable型蛍光プローブの開発2021
- Author(s)
  中館眞美子、小嶋良輔、浦野泰照
- Organizer
  日本ケミカルバイオロジー学会　第15回年会
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] HFSPを用いたスイス留学と，帰国後の研究立ち上げの事例2020
- Author(s)
  小嶋良輔
- Organizer
  RA協議会2020
- Invited
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] バーコード化EVが可能とするEV研究の新展開2020
- Author(s)
  小嶋良輔
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] “異分野融合”を形にするには何が必要なのだろうか　~SXRをミッション脱出のためのプロジェクト考案だけで終わらせないために~2020
- Author(s)
  小嶋良輔
- Organizer
  The 1st Scienc-ome XR Innovation Hub
- Invited
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] スーパー細ヤ胞をつくる2020
- Author(s)
  小嶋良輔
- Organizer
  8th Scienc-ome
- Invited
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] Designer Cellを用いた新たな疾患治療システムとその設計原理2020
- Author(s)
  小嶋良輔
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H02874
[Presentation] Development of a Novel Bio-orthogonal Probe - Reporter Enzyme Pair for Fluorescence Cancer Imaging2020
- Author(s)
  Wang Ziyi, Ryosuke Kojima, Yasuteru Urano
- Organizer
  第14回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-20H02874

1. 神谷真子 (90596462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. 水島昇 (10353434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 塚本智史 (80510693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 森下英晃 (90783499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小幡史明 (40748539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小関泰之 (60437374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 仲上豪二朗 (70547827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 真田弘美 (50143920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 酒井崇匡 (70456151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 野村征太郎 (10722118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 峰松健夫 (00398752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 秋下雅弘 (00261975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 佐久間一郎 (50178597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 花岡健二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小松徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 浦野泰照

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Kojima Ryosuke 小嶋 良輔

Research Projects

Research Products

Co-Researchers

Selective wound healing senolytics targeting senescent cells in wound exudate

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on intracellular degradation focusing on membranous structures

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel methods of fluorescence cancer imaging by utilizing combination of functional small molecules and proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innovative multiplex imaging with functional Raman probes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of functional Raman probes for innovative multiplex imaging

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Methods in Molecular Biology, Mammalian Cell Engineering2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorescence Probes for Imaging Basic Carboxypeptidase Activity in Living Cells with High Intracellular Retention2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intracellular Unnatural Catalysis Enabled by an Artificial Metalloenzyme2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Photoactivatable fluorophores for durable labelling of individual cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ?-glutamyl hydroxymethyl rhodamine green fluorescence as a prognostic indicator for lung cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multicolor Activatable Raman Probes for Simultaneous Detection of Plural Enzyme Activities2020

Author(s)

Journal Title

DOI

Kojima Ryosuke 小嶋良輔

[Presentation] 新たな先端医療創製を目指したものづくり　～機能性小分子の開発から、細胞機能の自在プログラミングまで～2021

[Presentation] “異分野融合”を形にするには何が必要なのだろうか　~SXRをミッション脱出のためのプロジェクト考案だけで終わらせないために~2020