ooyama hiroshi 大山広

… Alternative Names

Ohyama Hiroshi 大山広

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Researcher Number	10814600
Other IDs
Affiliation (Current)	2026: 千葉大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 千葉大学, 医学部附属病院, 講師 2021: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 胆道癌 / 膵癌 / 遺伝子変異 / がん遺伝子 / メタゲノム / がんゲノム解析 / ゲノム解析 / 腸内細菌叢 / 胆膵癌 / 次世代シークエンサー / ゲノミクス / 悪性新生物

Elucidation of the mechanism of pancreatic carcinogenesis focusing on dysbiosis of duodenal microflora and development of an early diagnosis methodPrincipal Investigator
- Principal Investigator
  
  大山広
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Genomic information in cytology archives; Toward precision medicine for the most refractory cancersPrincipal Investigator
- Principal Investigator
  
  Ohyama Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University

All 2025 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Anamorelin as a Therapeutic Option for Cancer Cachexia in Advanced Pancreatic Cancer: A Case Report Demonstrating Significant Weight Gain and Quality of Life Improvement2025
- Author(s)
  Kan Motoyasu、Ogane Yoshiki、Watabe Kazuki、Takahashi Tomoya、Sakai Miho、Sekine Yu、Yamada Nana、Sugihara Chihei、Ouchi Mayu、Nagashima Hiroki、Takahashi Koji、Okitsu Koichiro、Ohyama Hiroshi、Ohno Izumi、Kato Naoya
- Journal Title
  
  Intern. Med.
  
  Volume: 64 Issue: 15 Pages: 2312-2316
- DOI
  10.2169/internalmedicine.4708-24
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2025-08-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-24K11081
[Journal Article] The efficacy of bile liquid biopsy in the diagnosis and treatment of biliary tract cancer2024
- Author(s)
  Miura Yoshifumi、Ohyama Hiroshi、Mikata Rintaro、Hirotsu Yosuke、Amemiya Kenji、Mochizuki Hitoshi、Ikeda Junichiro、Ohtsuka Masayuki、Kato Naoya、Omata Masao
- Journal Title
  
  Journal of Hepato-Biliary-Pancreatic Sciences
  
  Volume: － Issue: 5 Pages: 329-338
- DOI
  10.1002/jhbp.1432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15963, KAKENHI-PROJECT-23K27646, KAKENHI-PROJECT-24K10137, KAKENHI-PROJECT-24K11081
[Journal Article] Liquid biopsy of wash samples obtained via endoscopic ultrasound‐guided fine‐needle biopsy: Comparison with liquid biopsy of plasma in pancreatic cancer2024
- Author(s)
  Ohyama Hiroshi、Hirotsu Yosuke、Amemiya Kenji、Amano Hiroyuki、Hirose Sumio、Oyama Toshio、Iimuro Yuji、Kojima Yuichiro、Mikata Rintaro、Mochizuki Hitoshi、Kato Naoya、Omata Masao
- Journal Title
  
  Diagnostic Cytopathology
  
  Volume: － Issue: 6 Pages: 325-331
- DOI
  10.1002/dc.25306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15963, KAKENHI-PROJECT-23K27646, KAKENHI-PROJECT-24K11081
[Journal Article] Genomic Analysis of Undifferentiated Carcinoma of the Pancreas with Squamous Differentiation: A Case Report2024
- Author(s)
  Kan Motoyasu、Kouchi Yusuke、Ohyama Hiroshi、Usui Genki、Fukuyo Masaki、Takano Shigetsugu、Kishimoto Takashi、Kaneda Atsushi、Ohtsuka Masayuki、Kato Naoya
- Journal Title
  
  Cureus
  
  Volume: -
- DOI
  10.7759/cureus.55175
- Data Source
  KAKENHI-PROJECT-24K11081
[Journal Article] Development of a molecular barcode detection system for pancreaticobiliary malignancies and comparison with next-generation sequencing2024
- Author(s)
  Ohyama Hiroshi、Hirotsu Yosuke、Amemiya Kenji、Mikata Rintaro、Amano Hiroyuki、Hirose Sumio、Oyama Toshio、Iimuro Yuji、Kojima Yuichiro、Mochizuki Hitoshi、Kato Naoya、Omata Masao
- Journal Title
  
  Cancer Genetics
  
  Volume: 280-281 Pages: 6-12
- DOI
  10.1016/j.cancergen.2023.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15963, KAKENHI-PROJECT-24K11081
[Journal Article] Distinct Genomic Profiles of Two Small Malignant Lesions Associated With an Intraductal Papillary Mucinous Neoplasm Co-occurring in a Patient2023
- Author(s)
  Ohyama Hiroshi、Hirotsu Yosuke、Mochizuki Hitoshi、Kato Naoya、Omata Masao
- Journal Title
  
  Cureus
  
  Volume: －
- DOI
  10.7759/cureus.51394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15963
[Journal Article] Comparison of genomic profiling of circulating tumor DNA in pancreaticobiliary malignancies in plasma and bile2023
- Author(s)
  Ohyama Hiroshi、Hirotsu Yosuke、Amemiya Kenji、Miura Yoshifumi、Hirose Sumio、Oyama Toshio、Iimuro Yuji、Kojima Yuichiro、Mikata Rintaro、Mochizuki Hitoshi、Kato Naoya、Omata Masao
- Journal Title
  
  Cancer
  
  Volume: 129 Issue: 11 Pages: 1714-1722
- DOI
  10.1002/cncr.34717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-21K15963, KAKENHI-PROJECT-23K27646
[Journal Article] Genomic profiling amplifies the utility of endoscopic ultrasound-guided fine needle biopsy by identifying clinically applicable druggable mutations in pancreatic cancer2022
- Author(s)
  Ohyama Hiroshi、Mikata Rintaro、Hirotsu Yosuke、Amemiya Kenji、Miura Yoshifumi、Hirose Sumio、Oyama Toshio、Takano Atsushi、Iimuro Yuji、Kojima Yuichiro、Mochizuki Hitoshi、Ikeda Junichiro、Kato Naoya、Omata Masao
- Journal Title
  
  Annals of Diagnostic Pathology
  
  Volume: 60 Pages: 152016-152016
- DOI
  10.1016/j.anndiagpath.2022.152016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-21K15963, KAKENHI-PROJECT-20H03668
[Journal Article] Detection of actionable mutations in cytological specimens obtained by endoscopic ultrasound-guided fine needle aspiration with rapid onsite evaluation in pancreatic cancer2022
- Author(s)
  Ohyama H, Hirotsu Y, Amemiya K, Amano H, Hirose S, Hosoda K, Oyama T, Iimuro Y, Kojima Y, Mikata R, Mochizuki H, Kato N, Omata M
- Journal Title
  
  Annals of Diagnostic Pathology
  
  Volume: 60 Pages: 152008-152008
- DOI
  10.1016/j.anndiagpath.2022.152008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15963, KAKENHI-PROJECT-20H03668
[Journal Article] Detection of actionable mutations in archived cytological bile specimens2021
- Author(s)
  Hiroshi Ohyama, Yosuke Hirotsu, Kenji Amemiya, Toshio Oyama, Yuji Iimuro, Yuichiro Kojima, Rintaro Mikata, Hitoshi Mochizuki, Naoya Kato, Masao Omata
- Journal Title
  
  Journal of hepato-biliary-pancreatic sciences
  
  Volume: 28 Issue: 10 Pages: 837-847
- DOI
  10.1002/jhbp.994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07707, KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-21K15963
[Presentation] Differentiation of biliary strictures with liquid biopsy using bile and its development into treatment2024
- Author(s)
  Hiroshi Ohyama, Naoya Kato, Masao Omata
- Organizer
  DDW 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11081
[Presentation] 胆汁リキッドバイオプシーによる胆道狭窄の良悪性診断と治療への展開2024
- Author(s)
  大山広、弘津陽介、雨宮健司、廣瀬純穂、小山敏雄、飯室勇二、望月仁、加藤直也、小俣政男
- Organizer
  第110回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-24K11081
[Presentation] Liquid biopsy of tumor-derived DNA in pancreaticobiliary malignancies in bile and plasma2024
- Author(s)
  Hiroshi Ohyama
- Organizer
  APASL 2024 Kyoto
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K11081
[Presentation] 胆膵癌の早期診断と精密医療の実現を目指した膵液、胆汁、血液のリキッドバイオプシー2024
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  JDDW 2024
- Data Source
  KAKENHI-PROJECT-24K11081
[Presentation] Liquid biopsy of tumor-derived DNA in pancreaticobiliary malignancies in bile and plasma.2024
- Author(s)
  Ohyama H
- Organizer
  APASL 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 鑑別困難な胆道狭窄の診断と治療における胆汁リキッドバイオプシーの有用性2024
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  JDDW 2024
- Data Source
  KAKENHI-PROJECT-24K11081
[Presentation] ゲノムプロファイリングを用いた膵・胆管合流異常における発癌リスクの検討2024
- Author(s)
  遠山翔大、大山広、雨宮健司、弘津陽介、酒井美帆、渡部主樹、高橋知也、山田奈々、関根優、杉原地平、大内麻愉、菅元泰、永嶌裕樹、高橋幸治、沖津恒一郎、大野泉、三島敬、高屋敷吏、小山敏雄、望月仁、大塚将之、加藤直也、小俣政男
- Organizer
  JDDW 2024
- Data Source
  KAKENHI-PROJECT-24K11081
[Presentation] 良悪性鑑別困難な胆管狭窄の診断と治療のための胆汁リキッドバイオプシー2024
- Author(s)
  大山広、弘津陽介、雨宮健司、酒井美帆、遠山翔大、望月仁、大塚将之、加藤直也、小俣政男
- Organizer
  第60回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-24K11081
[Presentation] 切除不能胆道癌における治療薬探索のための胆汁リキッドバイオプシー2023
- Author(s)
  大山広、弘津陽介、雨宮健司、遠山翔大、天野博之、望月仁、加藤直也、小俣政男
- Organizer
  第59回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 胆膵癌患者由来の液状検体に対する分子バーコードを用いたリキッドバイオプシー―ディープシーケンスとの比較―2023
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  JDDW2023
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] LIQUID BIOPSY FOR PANCREATICOBILIARY CANCER; MOLECULAR BARCODING VERSUS DEEP SEQUENCING2023
- Author(s)
  Ohyama H, Kato N, Omata M
- Organizer
  DDW 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 胆膵悪性腫瘍における胆汁リキッドバイオプシーの意義2023
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 膵胆道癌の診断感度向上を目指した分子バーコード技術を用いた低侵襲ゲノム解析の試み2023
- Author(s)
  大山広、弘津陽介、雨宮健司、天野博之、廣瀬純穂、飯室勇二、小山敏雄、小嶋裕一郎、望月仁、加藤直也、小俣政男
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] リキッドバイオプシーとしての胆汁ゲノム解析の可能性―血液との比較―2022
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  第30回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 胆膵悪性腫瘍における胆汁を用いたリキッドバイオプシー；血液との比較2022
- Author(s)
  大山広、弘津陽介、雨宮健司、三浦義史、菅元泰、小山敏雄、飯室勇二、小嶋裕一郎、三方林太郎、千葉哲博、望月仁、加藤直也、小俣政男
- Organizer
  第42回日本分子腫瘍マーカー研究会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 治療標的遺伝子変異探索を目指した胆汁リキッドバイオプシー2022
- Author(s)
  大山広、弘津陽介、雨宮健司、杉原地平、大内麻愉、菅元泰、永嶌裕樹、飯野陽太郎、高橋幸治、日下部裕子、沖津恒一郎、大野泉、望月仁、加藤直也、小俣政男
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] Actionable mutations of malignant biliary tumors can be detected in archived biliary cytology specimens2022
- Author(s)
  Hiroshi Ohyama, Naoya Kato, Masao Omata
- Organizer
  APASL Oncology 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] EUS-FNAにより得られた膵癌FFPE検体を活用した個別化医療の実現2022
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 膵癌EUS-FNA検体を用いたクリニカルシークエンスとリキッドバイオプシーによる治療薬探索2022
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  第103回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] GENOMIC PROFILE OF ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION IDENTIFIES CLINICALLY APPLICABLE DRUGGABLE MUTATIONS IN PANCREATIC CANCER2022
- Author(s)
  Hiroshi Ohyama, Naoya Kato, Masao Omata
- Organizer
  DDW 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 胆道狭窄における胆汁リキッドバイオプシーの可能性2022
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  第58回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 胆道由来細胞診検体のゲノム解析による早期診断と分子標的治療薬の検出2021
- Author(s)
  大山広、加藤直也、小俣政男
- Organizer
  第29回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-21K15963
[Presentation] 胆汁ゲノムプロファイル解析は手術不能悪性胆道狭窄例において分子標的治療薬探索に有用である2021
- Author(s)
  大山広、加藤直也、小俣政男、弘津陽介、雨宮健司、廣瀬純穂、日下部裕子、安井伸、杉山晴俊、大野泉、三方林太郎、小山敏雄、鷹野敦史、飯室勇二、望月仁
- Organizer
  第57回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15963

1. 弘津陽介 (10793838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. IKEDA Junichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 三方林太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ooyama hiroshi 大山 広

Ohyama Hiroshi 大山 広

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of pancreatic carcinogenesis focusing on dysbiosis of duodenal microflora and development of an early diagnosis methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genomic information in cytology archives; Toward precision medicine for the most refractory cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Anamorelin as a Therapeutic Option for Cancer Cachexia in Advanced Pancreatic Cancer: A Case Report Demonstrating Significant Weight Gain and Quality of Life Improvement2025

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] The efficacy of bile liquid biopsy in the diagnosis and treatment of biliary tract cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liquid biopsy of wash samples obtained via endoscopic ultrasound‐guided fine‐needle biopsy: Comparison with liquid biopsy of plasma in pancreatic cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genomic Analysis of Undifferentiated Carcinoma of the Pancreas with Squamous Differentiation: A Case Report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a molecular barcode detection system for pancreaticobiliary malignancies and comparison with next-generation sequencing2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct Genomic Profiles of Two Small Malignant Lesions Associated With an Intraductal Papillary Mucinous Neoplasm Co-occurring in a Patient2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of genomic profiling of circulating tumor DNA in pancreaticobiliary malignancies in plasma and bile2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genomic profiling amplifies the utility of endoscopic ultrasound-guided fine needle biopsy by identifying clinically applicable druggable mutations in pancreatic cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of actionable mutations in cytological specimens obtained by endoscopic ultrasound-guided fine needle aspiration with rapid onsite evaluation in pancreatic cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of actionable mutations in archived cytological bile specimens2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Differentiation of biliary strictures with liquid biopsy using bile and its development into treatment2024

Author(s)

Organizer

Data Source

[Presentation] 胆汁リキッドバイオプシーによる胆道狭窄の良悪性診断と治療への展開2024

Author(s)

Organizer

Data Source

[Presentation] Liquid biopsy of tumor-derived DNA in pancreaticobiliary malignancies in bile and plasma2024

Author(s)

ooyama hiroshi 大山広

Ohyama Hiroshi 大山広