hirotsu yosuke 弘津陽介

… Alternative Names

Yosuke Hirotsu 弘津陽介

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Researcher Number	10793838
Other IDs	https://orcid.org/0000-0002-8002-834X
Affiliation (Current)	2023: 地方独立行政法人山梨県立病院機構山梨県立中央病院(がんセンター局ゲノム解析センター), ゲノム解析センター, チーフ研究員
Affiliation (based on the past Project Information) *help	2019 – 2023: 地方独立行政法人山梨県立病院機構山梨県立中央病院(がんセンター局ゲノム解析センター), ゲノム解析センター, チーフ研究員 2018: 地方独立行政法人山梨県立病院機構山梨県立中央病院(がんセンター局総合ゲノム診療統括部ゲノム解析センタ, ゲノム解析センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Basic Section 53010:Gastroenterology-related / Basic Section 55010:General surgery and pediatric surgery-related Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 55040:Respiratory surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 耐性 / SARS-CoV-2 / COVID-19 / マイクロサテライト不安定性 / 不均一性 / 免疫チェックポイント / 腫瘍内不均一性 / 免疫染色 / ミスマッチ修復 / MSI … More / 胃がん / 変異 / ゲノム / 遺伝性 / 癌 / PARP / 卵巣癌 / 乳癌 / 生殖細胞系列 / BRCA1/2 … More Except Principal Investigator 肝細胞癌 / 脾機能亢進症 / 遺伝子解析 / microbiome / 悪性胸膜中皮腫 / 脾摘 / 肝発癌 / 門脈圧亢進症 / ゲノム解析 / 脾線維化 / 肝線維化 / 次世代シークエンサー / 液状検体 / 膵癌早期診断 / 分子バーコード / KRAS変異 / 十二指腸液 / リキッドバイオプシー / K-RAS変異 / 膵癌 / liquid biopsy / NGS / 胆膵癌 Less

新型コロナウイルスの3CLpro阻害薬に対する薬剤耐性機序と宿主免疫環境の解明Principal Investigator
- Principal Investigator
  
  弘津陽介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Yamanashi Prefectural Hospital Organization
肝脾臓器相関からみた肝発癌・進展における腫瘍免疫微小環境の解析
- Principal Investigator
  
  飯室勇二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Yamanashi Prefectural Hospital Organization
悪性胸膜中皮腫組織内マイクロバイオータと病態との相関に関する検討
- Principal Investigator
  
  樋口留美
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Yamanashi Prefectural Hospital Organization
Role of hepato-splenic interaction in portal hypertension
- Principal Investigator
  
  飯室勇二
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Yamanashi Prefectural Hospital Organization
MSI-high胃癌の腫瘍内細菌叢とゲノム不均一性による抗腫瘍免疫との関連Principal Investigator
- Principal Investigator
  
  弘津陽介
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yamanashi Prefectural Hospital Organization
Development of liquid biopsy for early diagnosis of pancreatic cancer using next generation sequence with molecular barcoding detection.
- Principal Investigator
  
  Mikata Rintaro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba University
Mechanisms of carcinogenesis in individuals harboring germline BRCA1/2 pathogenic variantsPrincipal Investigator
- Principal Investigator
  
  Yosuke Hirotsu
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Yamanashi Prefectural Hospital Organization

All 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 臨床検体を用いたパネル検査2019
- Author(s)
  弘津陽介
- Publisher
  肝胆膵アークメディア
- Data Source
  KAKENHI-PROJECT-18K16292
[Journal Article] TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report2022
- Author(s)
  Kunimasa Kei、Hirotsu Yosuke、Amemiya Kenji、Nakamura Harumi、Nishino Kazumi、Honma Keiichiro、Okami Jiro、Omata Masao、Kumagai Toru
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 3 Issue: 5 Pages: 100305-100305
- DOI
  10.1016/j.jtocrr.2022.100305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-19K17694
[Journal Article] A case of juvenile-onset pheochromocytoma with <i>KIF1B</i> p.V1529M germline mutation2022
- Author(s)
  Nezu Masahiro、Hirotsu Yosuke、Amemiya Kenji、Katsumata Miho、Watanabe Tomomi、Takizawa Soichi、Inoue Masaharu、Mochizuki Hitoshi、Hosaka Kyoko、Oyama Toshio、Omata Masao
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 6 Pages: 705-716
- DOI
  10.1507/endocrj.EJ21-0475
- NAID
  130008142628
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] SARS-CoV-2 Omicron sublineage BA.2 replaces BA.1.1: Genomic surveillance in Japan from September 2021 to March 20222022
- Author(s)
  Hirotsu Yosuke、Maejima Makoto、Shibusawa Masahiro、Natori Yume、Nagakubo Yuki、Hosaka Kazuhiro、Sueki Hitomi、Mochizuki Hitoshi、Tsutsui Toshiharu、Kakizaki Yumiko、Miyashita Yoshihiro、Omata Masao
- Journal Title
  
  Journal of Infection
  
  Volume: - Issue: 2 Pages: 174-211
- DOI
  10.1016/j.jinf.2022.04.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Non-pharmaceutical interventions during the COVID-19 epidemic changed detection rates of other circulating respiratory pathogens in Japan2022
- Author(s)
  Nagakubo Yuki、Hirotsu Yosuke、Maejima Makoto、Shibusawa Masahiro、Hosaka Kazuhiro、Amemiya Kenji、Sueki Hitomi、Hayakawa Miyoko、Mochizuki Hitoshi、Tsutsui Toshiharu、Kakizaki Yumiko、Miyashita Yoshihiro、Omata Masao
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 1 Pages: e0262874-e0262874
- DOI
  10.1371/journal.pone.0262874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] PIK3CA-AKT pathway predominantly acts in developing ipsilateral breast tumor recurrence long after breast-conserving surgery2022
- Author(s)
  Nakagomi Hiroshi、Inoue Masayuki、Hirotsu Yosuke、Amemiya Kenji、Mochiduki Hitoshi、Omata Masao
- Journal Title
  
  Breast Cancer Research and Treatment
  
  Volume: 193 Issue: 2 Pages: 349-359
- DOI
  10.1007/s10549-022-06570-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] The Diagnostic Utility of Cell-Free DNA from Ex Vivo Bronchoalveolar Lavage Fluid in Lung Cancer2022
- Author(s)
  Otake Sotaro、Goto Taichiro、Higuchi Rumi、Nakagomi Takahiro、Hirotsu Yosuke、Amemiya Kenji、Oyama Toshio、Mochizuki Hitoshi、Omata Masao
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 7 Pages: 1764-1764
- DOI
  10.3390/cancers14071764
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Direct comparison of Xpert Xpress, FilmArray Respiratory Panel, Lumipulse antigen test, and RT-qPCR in 165 nasopharyngeal swabs2022
- Author(s)
  Hirotsu Yosuke、Maejima Makoto、Shibusawa Masahiro、Natori Yume、Nagakubo Yuki、Hosaka Kazuhiro、Sueki Hitomi、Amemiya Kenji、Hayakawa Miyoko、Mochizuki Hitoshi、Tsutsui Toshiharu、Kakizaki Yumiko、Miyashita Yoshihiro、Omata Masao
- Journal Title
  
  BMC Infectious Diseases
  
  Volume: 22 Issue: 1
- DOI
  10.1186/s12879-022-07185-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Discovery of a SARS-CoV-2 variant from the P.1 lineage harboring K417T/E484K/N501Y mutations in Kofu, Japan2021
- Author(s)
  Hirotsu Yosuke、Omata Masao
- Journal Title
  
  Journal of Infection
  
  Volume: 82 Issue: 6 Pages: 276-316
- DOI
  10.1016/j.jinf.2021.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Actionable driver DNA variants and fusion genes can be detected in archived cytological specimens with the Oncomine Dx Target Test Multi‐CDx system in lung cancer2021
- Author(s)
  Amemiya Kenji、Hirotsu Yosuke、Nagakubo Yuki、Mochizuki Hitoshi、Higuchi Rumi、Tsutsui Toshiharu、Kakizaki Yumiko、Miyashita Yoshihiro、Oyama Toshio、Omata Masao
- Journal Title
  
  Cancer Cytopathology
  
  Volume: 129 Issue: 9 Pages: 729-738
- DOI
  10.1002/cncy.22434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Detection of actionable mutations in archived cytological bile specimens2021
- Author(s)
  Hiroshi Ohyama, Yosuke Hirotsu, Kenji Amemiya, Toshio Oyama, Yuji Iimuro, Yuichiro Kojima, Rintaro Mikata, Hitoshi Mochizuki, Naoya Kato, Masao Omata
- Journal Title
  
  Journal of hepato-biliary-pancreatic sciences
  
  Volume: 28 Issue: 10 Pages: 837-847
- DOI
  10.1002/jhbp.994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07707, KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-21K15963
[Journal Article] Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients2021
- Author(s)
  Tokunaga Mamoru、Okimoto Kenichiro、Akizue Naoki、Ishikawa Kentaro、Hirotsu Yosuke、Amemiya Kenji、Ota Masayuki、Matsusaka Keisuke、et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17671-17671
- DOI
  10.1038/s41598-021-97249-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K17451, KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-21K07956
[Journal Article] Robust Antibody Responses to the BNT162b2 mRNA Vaccine Occur Within a Week After the First Dose in Previously Infected Individuals and After the Second Dose in Uninfected Individuals2021
- Author(s)
  Hirotsu Yosuke、Amemiya Kenji、Sugiura Hiroki、Shinohara Miyuki、Takatori Mika、Mochizuki Hitoshi、Omata Masao
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12
- DOI
  10.3389/fimmu.2021.722766
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Comparison of Roche and Lumipulse quantitative SARS-CoV-2 antigen test performance using automated systems for the diagnosis of COVID-192021
- Author(s)
  Hirotsu Yosuke、Sugiura Hiroki、Maejima Makoto、Hayakawa Miyoko、Mochizuki Hitoshi、Tsutsui Toshiharu、Kakizaki Yumiko、Miyashita Yoshihiro、Omata Masao
- Journal Title
  
  International Journal of Infectious Diseases
  
  Volume: 108 Pages: 263-269
- DOI
  10.1016/j.ijid.2021.05.067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] EML4-ALK fusion variant.3 and co-occurrent PIK3CA E542K mutation exhibiting primary resistance to three generations of ALK inhibitors2021
- Author(s)
  Kunimasa Kei、Hirotsu Yosuke、Kukita Yoji、Ueda Yumi、Sato Yoshiharu、Kimura Madoka、Otsuka Tomoyuki、Hamamoto Yuichiro、Tamiya Motohiro、Inoue Takako、Kawamura Takahisa、Nishino Kazumi、Amemiya Kenji、Goto Taichiro、Mochizuki Hitoshi、Honma Keiichiro、Omata Masao、Kumagai Toru
- Journal Title
  
  Cancer Genetics
  
  Volume: 256-257 Pages: 131-135
- DOI
  10.1016/j.cancergen.2021.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-19K17694
[Journal Article] Prospective study of 1308 nasopharyngeal swabs from 1033 patients using the LUMIPULSE SARS-CoV-2 antigen test: Comparison with RT-qPCR2021
- Author(s)
  Hirotsu Yosuke、Maejima Makoto、Shibusawa Masahiro、Amemiya Kenji、Nagakubo Yuki、Hosaka Kazuhiro、Sueki Hitomi、Hayakawa Miyoko、Mochizuki Hitoshi、Tsutsui Toshiharu、Kakizaki Yumiko、Miyashita Yoshihiro、Omata Masao
- Journal Title
  
  International Journal of Infectious Diseases
  
  Volume: 105 Pages: 7-14
- DOI
  10.1016/j.ijid.2021.02.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Lung Cancer Surgery with Persistent COVID-19 Infection2021
- Author(s)
  Nakagomi Takahiro、Goto Taichiro、Hirotsu Yosuke、Higuchi Rumi、Tsutsui Toshiharu、Amemiya Kenji、Oyama Toshio、Mochizuki Hitoshi、Omata Masao
- Journal Title
  
  The Annals of Thoracic Surgery
  
  Volume: - Issue: 2 Pages: e79-e81
- DOI
  10.1016/j.athoracsur.2021.11.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Sphingomonas and Phenylobacterium as Major Microbiota in Thymic Epithelial Tumors2021
- Author(s)
  Higuchi Rumi、Goto Taichiro、Hirotsu Yosuke、Otake Sotaro、Oyama Toshio、Amemiya Kenji、Ohyama Hiroshi、Mochizuki Hitoshi、Omata Masao
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 11 Issue: 11 Pages: 1092-1092
- DOI
  10.3390/jpm11111092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] SARS-CoV-2 B.1.1.7 lineage rapidly spreads and replaces R.1 lineage in Japan: Serial and stationary observation in a community2021
- Author(s)
  Hirotsu Yosuke、Omata Masao
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 95 Pages: 105088-105088
- DOI
  10.1016/j.meegid.2021.105088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Streptococcus australis and Ralstonia pickettii as Major Microbiota in Mesotheliomas2021
- Author(s)
  Higuchi Rumi、Goto Taichiro、Hirotsu Yosuke、Otake Sotaro、Oyama Toshio、Amemiya Kenji、Mochizuki Hitoshi、Omata Masao
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 11 Issue: 4 Pages: 297-297
- DOI
  10.3390/jpm11040297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Discrepancy Between Clinical Diagnosis and Whole-exome Sequencing-based Clonality Analysis of Synchronous Multiple Oral Cancers2021
- Author(s)
  NISHII NAOTO、HIROTSU YOSUKE、KOIDA NAMI、TAKAHASHI YUKINOBU、TAKAGAWA YUKI、AMEMIYA KENJI、OYAMA TOSHIO、MOCHIZUKI HITOSHI、FURUSAWA-NISHII EMI、HARADA HIROYUKI、OMATA MASAO
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 2 Pages: 1035-1040
- DOI
  10.21873/anticanres.14859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18959, KAKENHI-PROJECT-20H03668
[Journal Article] Comprehensive mutational analysis of background mucosa in patients with Lugol‐voiding lesions2021
- Author(s)
  Akizue Naoki、Okimoto Kenichiro、Arai Makoto、Hirotsu Yosuke、Amemiya Kenji、Oura Hirotaka、Kaneko Tatsuya et al
- Journal Title
  
  Cancer Medicine
  
  Volume: 10 Issue: 11 Pages: 3545-3555
- DOI
  10.1002/cam4.3905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-20K17012
[Journal Article] The dynamic change of antibody index against Covid-19 is a powerful diagnostic tool for the early phase of the infection and salvage PCR assay errors2021
- Author(s)
  Omata Masao、Hirotsu Yosuke、Sugiura Hiroki、Maejima Makoto、Nagakubo Yuki、Amemiya Kenji、Hayakawa Miyoko、Tsutsui Toshiharu、Kakizaki Yumiko、Mochizuki Hitoshi、Miyashita Yoshihiro
- Journal Title
  
  Journal of Microbiology, Immunology and Infection
  
  Volume: 54 Issue: 5 Pages: 830-838
- DOI
  10.1016/j.jmii.2020.12.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Analysis of a persistent viral shedding patient infected with SARS-CoV-2 by RT-qPCR, FilmArray Respiratory Panel v2.1, and antigen detection2021
- Author(s)
  Hirotsu Yosuke、Maejima Makoto、Shibusawa Masahiro、Amemiya Kenji、Nagakubo Yuki、Hosaka Kazuhiro、Sueki Hitomi、Hayakawa Miyoko、Mochizuki Hitoshi、Tsutsui Toshiharu、Kakizaki Yumiko、Miyashita Yoshihiro、Omata Masao
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 27 Issue: 2 Pages: 406-409
- DOI
  10.1016/j.jiac.2020.10.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan2021
- Author(s)
  Hirotsu Yosuke、Omata Masao
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 6 Pages: e1009619-e1009619
- DOI
  10.1371/journal.ppat.1009619
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Discrimination Between Primary Lung Cancer and Lung Metastases by Genomic Profiling2021
- Author(s)
  Higuchi Rumi、Goto Taichiro、Nakagomi Takahiro、Hirotsu Yosuke、Oyama Toshio、Amemiya Kenji、Mochizuki Hitoshi、Omata Masao
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 2 Issue: 12 Pages: 100255-100255
- DOI
  10.1016/j.jtocrr.2021.100255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection2021
- Author(s)
  Amano Hiroyuki、Kanda Tatsuo、Mochizuki Hitoshi、Kojima Yuichiro、Suzuki Yoji、Hosoda Kenji、Ashizawa Hiroshi、Miura Yuko、Tsunoda Shotaro、Hirotsu Yosuke、Ohyama Hiroshi、Kato Naoya、Moriyama Mitsuhiko、Obi Shuntaro、Omata Masao
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 11 Pages: 2216-2216
- DOI
  10.3390/v13112216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668
[Journal Article] Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates With Predicted PARP Inhibitor Efficacy Association by MH Guide2020
- Author(s)
  Hirotsu Y, Schmidt-Edelkraut U, Nakagomi H, Sakamoto I, Hartenfeller M, Narang R, Soldatos TG, Kaduthanam S, Wang X, Hettich S, Brock S, Jackson DB, Omata M
- Journal Title
  
  Int J Mol Sci
  
  Volume: 21 Issue: 11 Pages: 3895-3895
- DOI
  10.3390/ijms21113895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16292
[Journal Article] Durable Response by Olaparib for a Japanese Patient With Primary Peritoneal Cancer With Multiple Brain Metastases: A Case Report2019
- Author(s)
  Sakamoto I, Hirotsu Y, Nakagomi H, Ikegami A, Teramoto K, Omata M
- Journal Title
  
  J Obstet Gynaecol Res.
  
  Volume: 45 Issue: 3 Pages: 743-747
- DOI
  10.1111/jog.13851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16292
[Presentation] 胆道疾患における胆汁を用いたLiquid biopsyの有用性の検討2021
- Author(s)
  三浦義史、大山広、三方林太郎、杉山晴俊、安井伸、大野泉、日下部裕子、弘津陽介、雨宮健司、望月仁、千葉哲博、池田純一郎、大塚将之、小俣政男、加藤直也
- Organizer
  JDDW2021
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] Multifocal HCCs genetically classified as Multicentric Occurrence (MO) possess better prognosis after surgery comparing to Intrahepatic Metastasis (IM)2021
- Author(s)
  Yuji Iimuro1, Atsushi Takano, Kenji Amemiya, Yosuke Hirotsu, Hitoshi Mochizuki, Shuntaro Obi, and Masao Omata
- Organizer
  APASL 2022
- Data Source
  KAKENHI-PROJECT-20K08998
[Presentation] 胆膵癌に対するリキッドバイオプシー；分子バーコードとdeep sequencingとの対比2021
- Author(s)
  大山広, 弘津陽介, 雨宮健司, 鷹野敦史, 三方林太郎, 小山敏雄, 飯室勇二, 望月仁, 加藤直也, 小俣政男
- Organizer
  第25回日本外科病理学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07707
[Presentation] SVR後肝発癌の遺伝子プロファイルの特徴2021
- Author(s)
  大山広、小尾俊太郎、大岡美彦、弘津陽介、雨宮健司、飯室勇二、望月仁、加藤直也、小俣政男
- Organizer
  第57回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] 胆汁ゲノムプロファイル解析は手術不能悪性胆道狭窄例において分子標的治療薬探索に有用である2021
- Author(s)
  大山広、加藤直也、小俣政男、弘津陽介、雨宮健司、廣瀬純穂、日下部裕子、安井伸、杉山晴俊、大野泉、三方林太郎、小山敏雄、鷹野敦史、飯室勇二、望月仁
- Organizer
  第57回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] EUS-FNAで得られた膵癌組織検体のゲノム解析は治療標的遺伝子変異を検出できる2021
- Author(s)
  大山広、弘津陽介、雨宮健司、飯室勇二、小山敏雄、三方林太郎、望月仁、加藤直也、小俣政男
- Organizer
  第52回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] In houseがんパネル12種，施行10,687検体；ゲノム解析センターの開設と臨床への応用2021
- Author(s)
  大山広、弘津陽介、小俣政男
- Organizer
  JDDW2021
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] Phenotypic and Genetic Features of Multiple Nodules in HCC Based on Tumor Evolutionary Trait2021
- Author(s)
  Yosuke Hirotsu, Yuji Iimuro, Kenji Amemiya, Hitoshi Mochizuki, Masao Omata
- Organizer
  APASL Oncology2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] Genetic discrimination between Multicentric Occurrence and Intrahepatic Metastasis in multifocal HCC2021
- Author(s)
  Yuji Iimuro, Atsushi Takano, Kenji Amemiya, Yosuke Hirotsu, Hitoshi Mochizuki, Shuntaro Obi, and Masao Omata
- Organizer
  APASL Oncology 2021
- Data Source
  KAKENHI-PROJECT-20K08998
[Presentation] ダイヤモンドプリンセス号から変異株同定まで; ワンチームのこの1年2021
- Author(s)
  弘津陽介、望月仁、小俣政男
- Organizer
  JDDW2021
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] 細胞診検体でオンコマインDx Target Test Multi-CDx systemを用いてDNAバリアントと融合遺伝子探索が可能2021
- Author(s)
  雨宮健司、弘津陽介、長久保由貴、望月仁、筒井俊晴、柿崎由美子、宮下義啓、小山敏雄、小俣政男
- Organizer
  第28回日本遺伝子診療学会
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] Genetic Discrimination between Multicentric Occurrence and Intrahepatic Metastasis in Multifocal HCC2021
- Author(s)
  Yuji Iimuro, Atsushi Takano, Kenji Amemiya, Yosuke Hirotsu, Hitoshi Mochizuki, Shuntaro Obi, Masao Omata
- Organizer
  APASL Oncology2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] EUS-FNAで得られた膵癌組織検体のゲノム解析は治療標的遺伝子変異を検出できる2021
- Author(s)
  大山広, 弘津陽介, 雨宮健司, 飯室勇二, 小山敏雄, 三方林太郎, 望月仁, 加藤直也, 小俣政男
- Organizer
  第52回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-19K07707
[Presentation] Is Liver Carcinogenesis after SVR IM or MC? By Analysis of Gene Profiles2021
- Author(s)
  Shuntaro Obi, Kenji Amemiya, Yosuke Hirotsu, Hitoshi Mochizuki, Yuichiro Kojima, Yoji Suzuki, Kazuhiko Hosoda, Hiroshi Ohyama, Sumio Hirose, Hiroyuki Amano, Kyoko Nakajima, Akihiro Abe, Miho Kanda, Masao Omata
- Organizer
  APASL Oncology2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] 胆膵癌に対するリキッドバイオプシー；分子バーコードとdeep sequencingとの対比2021
- Author(s)
  大山広、弘津陽介、雨宮健司、鷹野敦史、三方林太郎、小山敏雄、飯室勇二、望月仁、加藤直也、小俣政男
- Organizer
  第25回日本外科病理学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] 胆汁ゲノムプロファイル解析は手術不能悪性胆道狭窄例において分子標的治療薬探索に有用である2021
- Author(s)
  大山広,加藤直也, 小俣政男, 弘津陽介, 雨宮健司, 廣瀬純穂, 三方林太郎, 小山敏雄, 鷹野敦史, 飯室勇二, 望月仁
- Organizer
  第57回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07707
[Presentation] ”Pooling Method”(核酸)・抗原・抗体診断確立による遅滞のない内視鏡遂行体験2021
- Author(s)
  小嶋裕一郎、弘津陽介、小俣政男
- Organizer
  JDDW2021
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] Diagnosis, Genome Surveillance and Immune Response of COVID-192021
- Author(s)
  Yosuke Hirotsu
- Organizer
  APASL Oncology2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] マイクロサテライト不安定検査の院内実装；ミスマッチ修復遺伝子の免疫組織学的検討 (IHC,MSI-PCRおよびMSI-NGSの対比)2021
- Author(s)
  雨宮健司、弘津陽介、小俣政男
- Organizer
  JDDW2021
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] 子宮体癌におけるmicrosatellite instability statusの多様性2021
- Author(s)
  野﨑敬博、加々美桂子、松田康佑、雨宮健司、弘津陽介、坂本育子
- Organizer
  第63回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] 卵巣癌における腹水細胞診標本を用いた遺伝子解析の有用性2021
- Author(s)
  野﨑敬博、加々美桂子、松田康佑、雨宮健司、弘津陽介、坂本育子
- Organizer
  第73回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] Major Signaling Pathway in Hepatocellular Carcinoma and Drug-matched Variants2021
- Author(s)
  Kenji Amemiya, Yosuke Hirotsu, Masao Omata
- Organizer
  APASL Oncology2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03668
[Presentation] Post-SVR時代の肝癌治療におけるMinimal Invasive Hepatectomyの有用性2021
- Author(s)
  飯室勇二、小尾俊太郎、望月仁、大山宏、弘津陽介、雨宮健司、小俣政男
- Organizer
  第５７回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20K08998
[Presentation] 胆道疾患における胆汁を用いたLiquid biopsyの有用性の検討2021
- Author(s)
  三浦義史, 大山広, 三方林太郎, 杉山晴俊, 安井伸, 大野泉, 日下部裕子, 弘津陽介, 雨宮健司, 望月仁, 千葉哲博, 池田純一郎, 大塚将之, 小俣政男, 加藤直也
- Organizer
  JDDW 2021（第63回日本消化器病学会大会）
- Data Source
  KAKENHI-PROJECT-19K07707
[Presentation] ゲノム情報と知識データベースの融合による治療薬の選択2019
- Author(s)
  弘津陽介
- Organizer
  第22回分子標的治療学会
- Data Source
  KAKENHI-PROJECT-18K16292
[Presentation] 遺伝子パネル検査の院内実装と精度管理・外部認定取得に向けて2019
- Author(s)
  弘津陽介
- Organizer
  第26回日本乳がん学会
- Data Source
  KAKENHI-PROJECT-18K16292
[Presentation] BRCA1/2生殖細胞系列変異保因者の癌組織中における遺伝子異常2019
- Author(s)
  弘津陽介
- Organizer
  第27回日本乳癌学会
- Data Source
  KAKENHI-PROJECT-18K16292

1. 飯室勇二 (30252018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 河野寛 (40322127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Mikata Rintaro (60596146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 鈴村和大 (50434949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 波多野悦朗 (80359801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 樋口留美 (50895795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 後藤太一郎 (80317148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 西井直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

hirotsu yosuke 弘津 陽介

Yosuke Hirotsu 弘津 陽介

Research Projects

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Co-Researchers

新型コロナウイルスの3CLpro阻害薬に対する薬剤耐性機序と宿主免疫環境の解明Principal Investigator

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肝脾臓器相関からみた肝発癌・進展における腫瘍免疫微小環境の解析

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悪性胸膜中皮腫組織内マイクロバイオータと病態との相関に関する検討

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Role of hepato-splenic interaction in portal hypertension

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MSI-high胃癌の腫瘍内細菌叢とゲノム不均一性による抗腫瘍免疫との関連Principal Investigator

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Development of liquid biopsy for early diagnosis of pancreatic cancer using next generation sequence with molecular barcoding detection.

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Mechanisms of carcinogenesis in individuals harboring germline BRCA1/2 pathogenic variantsPrincipal Investigator

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[Book] 臨床検体を用いたパネル検査2019

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[Journal Article] TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report2022

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[Journal Article] A case of juvenile-onset pheochromocytoma with <i>KIF1B</i> p.V1529M germline mutation2022

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[Journal Article] SARS-CoV-2 Omicron sublineage BA.2 replaces BA.1.1: Genomic surveillance in Japan from September 2021 to March 20222022

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[Journal Article] Non-pharmaceutical interventions during the COVID-19 epidemic changed detection rates of other circulating respiratory pathogens in Japan2022

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[Journal Article] PIK3CA-AKT pathway predominantly acts in developing ipsilateral breast tumor recurrence long after breast-conserving surgery2022

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[Journal Article] The Diagnostic Utility of Cell-Free DNA from Ex Vivo Bronchoalveolar Lavage Fluid in Lung Cancer2022

hirotsu yosuke 弘津陽介

Yosuke Hirotsu 弘津陽介