KONO Hiroshi 河野寛

Researcher Number	40322127
Other IDs
Affiliation *help	2017 – 2018 : 山梨大学, 大学院総合研究部, 准教授 2017 – 2018 : 山梨大学, 総合研究部, 准教授 2015 – 2016 : 山梨大学, 総合研究部, 講師 2011 – 2013 : 山梨大学, 医学工学総合研究部, 助教 2007 – 2011 : University of Yamanashi, 大学院・医学工学総合研究部, 助教 … More
Review Section/Research Field	Principal Investigator Digestive surgery / General surgery / Digestive surgery Except Principal Investigator Digestive surgery / General surgery
Keywords	Principal Investigator Kupffer細胞 / サイトカイン / 腹膜炎 / ケモカイン / Kupffer cell / マクロファージ / 急性肺障害 / オキシダントストレス / 臓器相関 / NMGB1 … More Except Principal Investigator マクロファージ / 肝Kupffer細胞 / Kupffer細胞 / 肝再生 / M-CSF / IL-17A / 外科 / 肝類洞壁細胞 / HMGB1 / 肝線維化 / glycyrrhizin / CLEC-2 / 脾摘 / スフェロイド / 人工肝臓補助システム / 肝温虚血再還流モデル / サイトカイン / 感染免疫 / op/op mouse / 盲腸結紮穿刺 / IL-17A KO mouse / ポリウレタン膜 / 肝不全 / 肝免疫 / 急性肝不全 / CD4陽性リンパ球 / 肝類洞壁内皮細胞 / 感染制御 / 腹腔内感染 / 細胞・組織 / 塩化ガドリニウム / 脾線維化 / 血管新生因子 / CLPモデル / 肝発癌 / 肝細胞癌 / 人工肝補助装置 / 門脈圧亢進症 / 肝Kuffer細胞 / 肝障害 / 脾腫 / 免疫機能改善 / 中鎖脂肪酸 / 脾臓摘出 / 急性肺障害 / 人工肝臓システム / 肝腫瘍 / 肝マクロファージ / 十全大補湯 / 新生血管 / TNF-α / 盲腸結紮穿刺モデル / 肝切除後肝再生 / 制御性T細胞 / 血小板 / 肝実質細胞 / IL-10 / GCSF / CLP model / IL-17 / ノックアウトマウス / 肝kupffer細胞 Less

脾腫に伴う脾臓機能異常と肝線維化・肝発癌における肝脾臓器相関の解明Ongoing
- Principal Investigator
  
  飯室勇二
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  University of Yamanashi
下垂体アデニル酸シクラーゼ活性化ポリペプチドによる細菌性腹膜炎の制御と、臨床応用Principal InvestigatorOngoing
- Principal Investigator
  
  河野寛
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  University of Yamanashi
Role of M-CSF in hepatocarcinogenesis
- Principal Investigator
  
  細村直弘
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Role of CLEC-2 in hepatic regeneration and fibrosis
- Principal Investigator
  
  AMEMIYA Hidetake
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Development of artificial liver support system combining with liver cells and Kuppfer cells.
- Principal Investigator
  
  FUJII Hideki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Investigation of relationship between the liver and spleen via the portal circulation in sepsisPrincipal Investigator
- Principal Investigator
  
  KONO Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Development of artificial liver support system combining with liver cells and Kuppfer cells
- Principal Investigator
  
  FUJII Hideki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  University of Yamanashi
Investigation of organ interaction in the innate immune system during inflammationPrincipal Investigator
- Principal Investigator
  
  KONO Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Investigation of heterogeneity of tissue macrophages and inflammatory immune response during infection.Principal Investigator
- Principal Investigator
  
  KONO Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi
Role of the Kupffer cell in hepatic carcinogenesis in patients infected with hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  KONO Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Yamanashi, Faculty of Medicine

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2004 2003 Other

All Journal Article Presentation

[Journal Article] Macrophage colony-stimulating factor plays a pivotal role in chemically induced hepatocellular carcinoma in mice2014
- Author(s)
  Hara M, Kono H, Furuya S, Hirayama K, Tsuchiya M, Fujii H
- Journal Title
  
  Hepatol Res
  
  Volume : 44(7) Pages : 798-811
- DOI
  10.1111/hepr.12174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462040, KAKENHI-PROJECT-23591984
[Journal Article] The MAPK Pathway Is a Predominant Regulator of HLA-A Expression in Es ophageal and Gastric Cancer2013
- Author(s)
  Mimura K, Shiraishi K, Mueller A, I zawa S, Kua LF, So J, Yong WP, Fuji i H, Seliger B, Kiessling R, Kono K.
- Journal Title
  
  J Immunol
  
  Volume : 191(12) Pages : 6261-72
- DOI
  10.4049/jimmunol.1301597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591984
[Journal Article] Lapatinib acts on gastric cancer through both antiproliferative function and augmentation of trastuzumab-mediated antibody-dependent cellular cytotoxicity.2013
- Author(s)
  Shiraishi K, Mimura K, Izawa S, Inoue A, Shiba S, Maruyama T, Watanabe M, Kawaguchi Y, Inoue M, Fujii H, Kono K.
- Journal Title
  
  Gastric Cancer
  
  Volume : 16(4) Pages : 571-580
- DOI
  10.1007/s10120-012-0219-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591984, KAKENHI-PROJECT-24591936, KAKENHI-PROJECT-24791404, KAKENHI-PROJECT-25861152, KAKENHI-PROJECT-22591452
[Journal Article] Interleukin-17A plays a pivotal role after partial hepatectomy in mice2013
- Author(s)
  Furuya S
- Journal Title
  
  J Surg Res.
  
  Volume : 184（2） Pages : 838-46
- DOI
  10.1016/j.jss.2013.03.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591984
[Journal Article] Increased prevalence of tumor-in filtrating regulatory T cells is closely related to their lower sensitivity to H2O2-induced apoptosis in gastric and esophageal cancer2013
- Author(s)
  Izawa S
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume : 62(1) Pages : 161-70
- DOI
  10.1007/s00262-012-1327-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591452, KAKENHI-PROJECT-23591984, KAKENHI-PROJECT-24591936
[Journal Article] Interleukin-17A plays a pivotal role in cholest aticliver fibrosis in mice2013
- Author(s)
  Hara M
- Journal Title
  
  J Surg Res.
  
  Volume : 183(2) Pages : 574-82
- DOI
  10.1016/j.jss.2013.03.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591984
[Journal Article] The Kupffer Cell Inhibition Exacerbates but Splenectomy Prevents Mortality in a Rat Septic Peritonitis Model2012
- Author(s)
  Kono H, Fujii H, Ogiku M, Hara M, Tsuchiya M, Ishii K, Hosomura N
- Journal Title
  
  J Surg Res
  
  Volume : (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] Interleukin-17A Plays a Pivotal Role in Polymicrobial Sepsis According to Studies Using IL-17A Knockout Mice2012
- Author(s)
  Ogiku M, Kono H, Hara M, Tsuchiya M, Fujii H
- Volume
  174(1)
- Pages
  142-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] The Kupffer cell inhibition exacerbates but splenectomy prevents mortality in a rat septic peritonitis model.2012
- Author(s)
  Hiroshi Kono
- Journal Title
  
  J Surg Res
  
  Volume : 175(1) Pages : 101-112
- DOI
  10.1016/j.jss.2011.02.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745, KAKENHI-PROJECT-23591984
[Journal Article] Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.2011
- Author(s)
  Hiroshi Kono
- Journal Title
  
  J Immunol.
  
  Volume : 187 Pages : 4818-4825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591984
[Journal Article] Liver regeneration is impaired in macrophage colony stimulating factor deficient mice after partial hepatectomy : the role of M-CSF-induced macrophages2011
- Author(s)
  Amemiya H, Kono H, and Fujii H
- Journal Title
  
  J Surg Res
  
  Volume : 165(1) Pages : 59-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] HCV-Related Proteins Activate Kupffer Cells Isolated from Human Liver Tissues2011
- Author(s)
  Hosomura N, Kono H, Tsuchiya M, Ishii K, Ogiku M, Matsuda M, Fujii H
- Journal Title
  
  Dig Dis Sci
  
  Volume : 56(4) Pages : 1057-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] Role of interleukin-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion in mice2011
- Author(s)
  Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, and Hara M
- Journal Title
  
  J. Immunol
  
  Volume : 187 Pages : 4818-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] Glycyrrhizin prevents liverinjury by inhibition of HMGB1 production by Kupffer cells after ischemia-reperfusion in rats2011
- Author(s)
  Ogiku M, Kono H, Hara M, Tsuchiya M, Fujii H
- Journal Title
  
  J PharmacolExp Ther
  
  Volume : 339(1) Pages : 93-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] Dietary medium-chain triglycerides prevent chemically induced experimental colitis in rats.2011
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Translational Research
  
  Volume : (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] The Kupffer cell inhibition exacerbates but splenectomy prevents mortality in a rat septic peritonitis model.2011
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Journal of Surgical Research
  
  Volume : (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] Dietary medium-chain triglycerides prevent chemically induced experimental colit is in rats2011
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Translational Research
  
  Volume : 155(3) Pages : 131-141
- DOI
  10.1016/j.trsl.2009.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] HCV-related proteins activate Kupffer cells isolated from human liver tissues2011
- Author(s)
  Hosomura N, Kono H, Tsuchiya M, Ishii K, Ogiku M, Matsuda M, Fujii H
- Journal Title
  
  Dig Dis Sci. 56(4)
  
  Pages : 1057-1064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Liver regeneration is impaired in macrophage colony stimulating factor deficient mice after partial hepatectomy the role of M-CSF-induced macrophages.2011
- Author(s)
  Amemiya H, Kono H, Fujii H
- Journal Title
  
  J Surg Res. 165(1)
  
  Pages : 59-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Inhibition of the Kupffer cell increases serum high mobility group box 1 levels in a rat septic peritonitis model2010
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Journal of Surgical Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] Dietary medium-chain triglycerides prevent chemically induced experimental colitis in rats.2010
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Trans.Res. 155
  
  Pages : 131-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591745
[Journal Article] Dietary medium-chain trigly cerides prevent chemically induced experimental colitis in rats2010
- Author(s)
  Kono H, Fujii H, Ishii K, Hosomura N, Ogiku M
- Journal Title
  
  Transl Res. 155(3)
  
  Pages : 131-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular car cinoma.2010
- Author(s)
  Tsuchiya M, Parker JS, Kono H, Matsuda M, Fujii H, Rusyn I
- Journal Title
  
  Mol Cancer. 9
  
  Pages : 74-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Enteral diets enriched with medium-chain triglycerides and N-3 fatty acids prevent chemically induced experimental colitis in rats.2010
- Author(s)
  Kono H, Fujii H, Ogiku M, Tsuchiya M, Ishii K, Hara M
- Journal Title
  
  Transl Res. 156(5)
  
  Pages : 282-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Enteral diets enriched with medium-chain triglycerides and N-3 fatty acids prevent chemically induced experimental colitis in rats.2010
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Translational Research
  
  Volume : 156 Pages : 282-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Inhibition of the Kupffer cell increased serum HMGB1 levels and the mortality in a rat septic peritonitis model2009
- Author(s)
  Kono H, Fujii H, Tsuchiya M, Hirai Y, Ishii K, Hosomura N.
- Journal Title
  
  J. Surg. Res In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591579
[Journal Article] Inhibition of the Kupffer cell increases serum high mobility group box 1 levels in a rat septic peritonitis model2009
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Journal of Surgical Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591579
[Journal Article] Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice.2009
- Author(s)
  Tanaka N, Kono H, Ishii K, Hosomura N, Fujii H
- Journal Title
  
  J Gastroenterol. 44(9)
  
  Pages : 983-990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Medium-chain triglycerides enhance mucous secretion and cell proliferation in the rat.2009
- Author(s)
  Ishii K, Kono H, Hosomura N, Tsuchiy a M, Ohgiku M, Tanaka N, Fujii H
- Journal Title
  
  J Gastroenterol. 44(3)
  
  Pages : 204-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Inhibition of the Kupffer cell increases serum high mobility group box 1levels in a rat septic peritonitis model2009
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Journal of Surgical Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Inhibition of the Kupffer cell and neutralization of IL-10 increase the expression of chemokines in the lung in a rat peritonitis model2008
- Author(s)
  Kono H, Fujii H, Tsuchiya M, Hirai Y, Ishii K, Hosomura N.
- Journal Title
  
  J. Surg. Res 150
  
  Pages : 169-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591579
[Journal Article] Inhibition of the Kupffer cell and neutralization of IL-10 increase the expression of chemokines in the lung in a rat peritonitis model2008
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Journal of Surgical Research 150
  
  Pages : 169-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591579
[Journal Article] Inhibition of the Kupffer cell and neutralization of IL-10 increase the expression of chemokines in the lung in a rat peritonitis model2008
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Journal of Surgical Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591579
[Journal Article] Protective effect of Juzen Taiho to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress.2008
- Author(s)
  Tsuchiya M, Kono H, Matsuda M, Fujii H, Rusyn I
- Journal Title
  
  Int J Cancer. 123(11)
  
  Pages : 2503-2511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Inhibition of the Kupffer cell and neutralization of IL-10 increase the expression of chemokines in the lung in a rat peritonitis model.2008
- Author(s)
  Kono H, Fujii H, Tsuchiya M, Hirai Y, Ishii K, Hosomura N, Tanaka N
- Journal Title
  
  J Surg Res. 150(2)
  
  Pages : 169-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Inhibition of the Kupffer cell and neutralization of IL-10 increase the expression of chemokines in the lung in a rat peritonitis model2008
- Author(s)
  Hiroshi Kono
- Journal Title
  
  Journal of Surgical Research 150
  
  Pages : 169-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] Medium-chain triglycerides modulate inflammatory immune response in the gut in rats administered endotoxin.2004
- Author(s)
  Kono H et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 286
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591394
[Journal Article] Medium-chain triglycerides modulate inflammatory immune response in the gut in rats administered endotoxin.2004
- Author(s)
  Kono H et al.
- Journal Title
  
  American Journal of Physiology 286
  
  Pages : 1081-1089
- Data Source
  KAKENHI-PROJECT-15591394
[Journal Article] Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin.2003
- Author(s)
  Kono H et al.
- Journal Title
  
  J Pharmacol Exp Ther 307
  
  Pages : 74-82
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591394
[Journal Article] Protective effects of medium-chain triglycerides on the liver and the gut in rats administered endotoxin.2003
- Author(s)
  Kono H et al.
- Journal Title
  
  Ann Surg 237
  
  Pages : 246-255
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591394
[Journal Article] Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin.2003
- Author(s)
  Kono H et al.
- Journal Title
  
  J Pharmacol Exp Ther 307(1)
  
  Pages : 74-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591394
[Journal Article] Interleukin-17A Plays a Pivotal Role in Polymicrobial Sepsis According to Studies Using IL-17A Knockout Mice.
- Author(s)
  Ogiku M, Kono H, Hara M, Tsuchiya M, Fujii H
- Journal Title
  
  J Surg Res.2010 [Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Journal Article] The Kupffer Cell Inhibition Exacerbates but Splenectomy Prevents Mortality in a Rat Septic Peritonitis Model.
- Author(s)
  Kono H, Fujii H, Ogiku M, Hara M, Tsuchiya M, Ishii K, Hosomura N
- Journal Title
  
  J Surg Res. 2011 [Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591516
[Presentation] 背景肝に発現するM-CSFの肝細胞癌発症おける関与の解明と、肝細胞癌の新規分子標的治療への応用2018
- Author(s)
  河野　寛
- Organizer
  日本消化器病学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10159
[Presentation] Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on the hepatic macrophages in septic peritonitis in mice2017
- Author(s)
  河野　寛
- Organizer
  アメリカ肝臓学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10508
[Presentation] Macrophage colony-stimulating factor (M-CSF) receptor antagonist inhibits progression of hepatocellular carcinoma in vivo2016
- Author(s)
  河野　寛
- Organizer
  APDW
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2016-11-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10159
[Presentation] M-CSF誘導肝マクロファージの肝細胞癌発症と進展おける関与の解明と、肝細胞癌の新規治療への応用2015
- Author(s)
  河野　寛、古屋信二、原倫生、平山和義、松田政徳、藤井秀樹
- Organizer
  第27回日本肝胆膵外科学会総会
- Place of Presentation
  ホテルグランパシフィック LE DAIBA 東京
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15K10159
[Presentation] 肝細胞癌発症と進展におけるM-CSFの関与と治療への応用2015
- Author(s)
  河野　寛、古屋信二、原倫生、赤澤祥弘、平山和義、中田裕紀、藤井秀樹
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台国際センター　宮城県仙台市
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K10159
[Presentation] 肝切除後肝再生における新規クラス血小板上受容体c-type lectin-like receptor 2 (CLEC-2)の役割2015
- Author(s)
  河野　寛、古屋信二、原倫生、土屋雅人、藤井秀樹
- Organizer
  第51回日本肝臓学会総会　2015年5月21日－22日
- Place of Presentation
  ホテル日航熊本　熊本県熊本市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25462083
[Presentation] 新規クラス血小板上受容体c-type lectin-like receptor 2 (CLEC-2)は、類洞内皮との相互作用で肝切除後肝再生の早期に重要な役割を果たす2015
- Author(s)
  河野　寛、古屋信二、原倫生、平山和義、藤井秀樹
- Organizer
  第36回日本炎症･再生医学会 2015年7月21-22日
- Place of Presentation
  六本木ヒルズ　東京都
- Year and Date
  2015-07-21
- Data Source
  KAKENHI-PROJECT-25462083
[Presentation] 肝切除後肝再生における新規クラス血小板上受容体c-type lectin-like receptor 2 (CLEC-2)の役割2014
- Author(s)
  河野　寛，藤井秀樹，原　倫生，古屋信二，平山和義
- Organizer
  第50回日本腹部救急医学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-25462083
[Presentation] 肝切除後肝再生における新規クラス血小板上受容体c-type lectin-like receptor 2 (CLEC-2)の役割2013
- Author(s)
  河野　寛，藤井秀樹，原　倫生，古屋信二，平山和義
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25462083
[Presentation] Interleukin-17a derived from the spleen plays a pivotal role in neutrophil recruitment into the liver after ischemia/reperfusion in mice2011
- Author(s)
  Hiroshi Kono, Masahito Ogiku, Michio Hara, Shinji, Furuya, Hideki Fujii
- Organizer
  IASGO 2011
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] Interleukin-17a derived from the spleen plays a pivotal role in neutrophil recruitment into the liver after ischemia/reperfusion in mice2011
- Author(s)
  Hiroshi Kono, Hideki Fujii, Masahito Ogiku, Michio Hara
- Organizer
  AASLD The Liver Meeting 2011
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 細菌性腹膜炎における肝臓と脾臓マクロファージの役割門脈を介した肝脾臓器相関2011
- Author(s)
  河野寛,藤井秀樹
- Organizer
  第23回日本肝胆膵外科学会・学術集会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 消化器病における漢方治療のエビデンスを目指して十全大補湯による肝細胞癌再予防効果の検討(ワークショップ)2011
- Author(s)
  河野寛,土屋雅人,藤井秀樹
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 細菌性腹膜炎における肝臓と脾臓マクロファージの役割-門脈を介した肝脾臓器相関2011
- Author(s)
  河野寛,大菊雅人,原倫生,土屋雅人,藤井秀樹
- Organizer
  第111回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 細菌性腹膜炎における、肝と脾臓の自然免疫を介した臓器相関2010
- Author(s)
  河野寛
- Organizer
  第46回日本腹部救急医学会総会
- Place of Presentation
  富山国際会議場
- Year and Date
  2010-03-12
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] Cholestasis-induced hepatic injury and fibrosis are attenuated in IL-17A-deficietnmice2010
- Author(s)
  Hiroshi Kono, Hideki Fujii
- Organizer
  The Liver Meeting 2010 AASLD's 61st Annual Meeting
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 細菌性腹膜炎における、肝と脾臓の自然免疫を介した臓器相関2010
- Author(s)
  河野寛,大菊正人,藤井秀樹
- Organizer
  第20回日本サイトメトリー学会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] C型肝炎ウイルス感染における背景肝の酸化ストレスと、肝細胞癌再発との関連に関する検討2010
- Author(s)
  河野寛,土屋雅人,藤井秀樹
- Organizer
  第46回日本肝癌研究会
- Place of Presentation
  大阪府
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 中鎖脂肪酸の投与によるエンドトキシン血症における肝臓ならびに消化管の抗炎症性効果2010
- Author(s)
  河野寛,藤井秀樹
- Organizer
  第22回日本肝胆膵外科学会・学術集会
- Place of Presentation
  宮城県
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 肝病態形成における酸化ストレスの意義C型肝炎ウイルス感染における背景肝の酸化ストレスと,肝細胞癌再発との関連に関する検討2010
- Author(s)
  河野寛,土屋雅人,藤井秀樹
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形県
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 炎症性腸疾患の栄養療法としての中鎖脂肪酸の有用性の検討2010
- Author(s)
  河野寛,藤井秀樹
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟県
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] Cholestasis-induced hepatic injury and fibrosis are attenuated in IL-17A-deficietnmice.2010
- Author(s)
  Kono H, Fujii H.
- Organizer
  The Liver Meeting 2010 AASLD's 61st Annual Meeting
- Place of Presentation
  Boston, MA
- Data Source
  KAKENHI-PROJECT-20591516
[Presentation] 細菌性腹膜炎における、肝と脾臓の自然免疫を介した臓器相関2009
- Author(s)
  河野寛
- Organizer
  第21回日本肝胆膵外科学会
- Place of Presentation
  ウェスティンナゴヤキャッスル
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] 細菌性腹膜炎における、肝と脾臓の自然免疫を介した臓器相関2009
- Author(s)
  河野寛
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸ポートピアボテル
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21591745
[Presentation] Inhibition of the Kupffer cell deteriorates and splenectomy prevents mortality in a rat septic peritonitis model.2009
- Author(s)
  Kono H, Fujii H, Ogiku M, Ishii K, Hosomura N.
- Organizer
  60th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, MA
- Data Source
  KAKENHI-PROJECT-20591516
[Presentation] Specific role of the interleukin-17 in neutrophil recruitment into the liver after ischemia/reperfusion.2009
- Author(s)
  Kono H, Ogiku M, Hosomura N, Fujii H.
- Organizer
  60th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston, MA
- Data Source
  KAKENHI-PROJECT-20591516
[Presentation] 炎症性腸疾患の発症機序におけるマクロファージの関与 : macrophage colony stimulating factor(M-CSF)役割2008
- Author(s)
  河野寛, 石井健一, 藤井秀樹
- Organizer
  第94 回日本消化器病学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 細菌性腹膜炎において、肝類洞免疫機能の低下はHigh-mobility group protein (HMGB)1発現を増加させる2008
- Author(s)
  河野寛, 藤井秀樹
- Organizer
  第44 回日本腹部救急医学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 細菌性腹膜炎において、肝類洞免疫機能の低下はHigh-mobility group protein(HMGB)1発現を増加させる2008
- Author(s)
  河野寛, 石井健一, 細村直弘, 田中暢之, 藤井秀樹
- Organizer
  第108 回日本外科学会定期学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 細菌性腹膜炎において, 肝類洞免疫能の低下はHigh-mobility group protein(HMGB)1発現を低下させる2008
- Author(s)
  河野寛, 石井健一, 細村直弘, 田中暢之, 藤井秀樹
- Organizer
  第44 回日本肝臓学会総会
- Place of Presentation
  愛媛
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] Inhibition of the Kupffer cell increases serum high-mobility group protein levels and mortality in a rat septic peritonitis model ; organ interaction between the liver and the spleen2008
- Author(s)
  Hiroshi Kono, Kenichi Ishii, Naohiro Hosomura, Maasto Ogiku, Hideki Fujii
- Organizer
  59th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  San Francisco, CA, U.S.A
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 細菌性腹膜炎において、肝類洞免疫能の低下はHigh-mobility group protein (HMGB) 1発現を増加させる2008
- Author(s)
  河野寛
- Organizer
  第20回日本肝胆膵外科学会・学術集会
- Place of Presentation
  山形国際ホテル
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 細菌性腹膜炎において、肝類洞免疫能の低下はHigh-mobility group protein (HMGB) 1発現を増加させる2008
- Author(s)
  河野寛
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 細菌性腹膜炎において、肝類洞免疫能の低下はHigh-mobility group protein (HMGB)1発現を増加させる2008
- Author(s)
  河野寛
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  愛媛県県民文化会館
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 細菌性腹膜炎において、肝類洞免疫能の低下はHigh-mobility group protein (HMGB)1発現を増加させる2008
- Author(s)
  河野寛
- Organizer
  第108回日本外科学会定期学術集会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-20591516
[Presentation] 細菌性腹膜炎において、肝類洞免疫能の低下はHigh-mobility group protein (HMGB)1発現を増加させる2008
- Author(s)
  河野寛
- Organizer
  第44回日本肝臓学会総会
- Place of Presentation
  愛媛県県民文化会館
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20591516
[Presentation] Edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage2007
- Author(s)
  Hiroshi Kono, Masanori Matsuda, Hideki Fujii
- Organizer
  1st Biennial Congress of APHPBA
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 診療と研究のトピックス肝類洞機能低下は肺障害を惹起する-肝肺臓器相関-2007
- Author(s)
  河野寛, 松田政徳, 藤井秀樹
- Organizer
  第43回日本腹部救急医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 肝類洞免疫能の低下が急性肺障害を惹起する-肝・肺臓器相関-2007
- Author(s)
  河野寛, 土屋雅人, 平井優, 雨宮秀武, 浅川真巳, 松田政徳, 藤井秀樹
- Organizer
  第107 回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] HCV-related proteins directly activate the Kupffer cell isolated from human liver tissues2007
- Author(s)
  Hiroshi Kono, Masato Tsuchiya, Naohiro Hosomura, Kenichi Ishii, Nobuyuki Tanaka, Masanori Matsuda, Hideki Fujii
- Organizer
  The 17th Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 肝類洞機能低下は肺障害を惹起する-肝肺臓器相関-2007
- Author(s)
  河野寛, 土屋雅人, 平井優, 雨宮秀武, 浅川真巳, 松田政徳, 藤井秀樹
- Organizer
  第19 回日本肝胆膵外科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 肝類洞免疫能の低下が急性肺傷害を惹起する-肝・肺臓器相関-2007
- Author(s)
  河野寛, 平井優, 細村直弘, 石井健一, 田中暢之, 松田政徳, 藤井秀樹
- Organizer
  第43 回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] HCV-related proteins induce proinflammatory cytokine production by the human Kupffer cell via the MyD88-dependent signaling cascade2007
- Author(s)
  Hiroshi Kono, Ishii Kenichi, Naohiro Hosomura, Nobuyuki Tanaka, Masanori Matsuda, Hideki Fujii
- Organizer
  58th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 肝類洞機能低下は肺傷害を惹起する-肝肺臓器相関-2007
- Author(s)
  河野寛
- Organizer
  第19回日本肝胆膵外科学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 肝類洞免疫能の低下が急性肺傷害を惹起する-肝・肺臓器相関-2007
- Author(s)
  河野寛
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  ホテルグランパシフィックメリディアン
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-19591579
[Presentation] 肝類洞機能低下は肺障害を惹起する-肝肺臓器相関-2007
- Author(s)
  河野寛
- Organizer
  日本外科学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-05-13
- Data Source
  KAKENHI-PROJECT-19591579

1. MATSUSA Masanori (80242642)

# of Collaborated Projects : 3results

# of Collaborated Products : 8results
2. FUJII Hideki (30181316)

# of Collaborated Projects : 3results

# of Collaborated Products : 20results
3. AMEMIYA Hidetake (70377547)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
4. HIRAI Yu (90436866)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
5. 細村直弘 (60402070)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 飯室勇二 (30252018)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 鈴村和大 (50434949)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 藤元治朗 (90199373)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

KONO Hiroshi 河野 寛

Research Projects

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脾腫に伴う脾臓機能異常と肝線維化・肝発癌における肝脾臓器相関の解明Ongoing

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下垂体アデニル酸シクラーゼ活性化ポリペプチドによる細菌性腹膜炎の制御と、臨床応用Principal InvestigatorOngoing

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Role of M-CSF in hepatocarcinogenesis

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Role of CLEC-2 in hepatic regeneration and fibrosis

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Development of artificial liver support system combining with liver cells and Kuppfer cells.

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Investigation of relationship between the liver and spleen via the portal circulation in sepsisPrincipal Investigator

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Development of artificial liver support system combining with liver cells and Kuppfer cells

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Investigation of organ interaction in the innate immune system during inflammationPrincipal Investigator

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Investigation of heterogeneity of tissue macrophages and inflammatory immune response during infection.Principal Investigator

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Role of the Kupffer cell in hepatic carcinogenesis in patients infected with hepatitis C virusPrincipal Investigator

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[Journal Article] Macrophage colony-stimulating factor plays a pivotal role in chemically induced hepatocellular carcinoma in mice2014

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[Journal Article] The MAPK Pathway Is a Predominant Regulator of HLA-A Expression in Es ophageal and Gastric Cancer2013

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[Journal Article] Lapatinib acts on gastric cancer through both antiproliferative function and augmentation of trastuzumab-mediated antibody-dependent cellular cytotoxicity.2013

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[Journal Article] Interleukin-17A plays a pivotal role after partial hepatectomy in mice2013

KONO Hiroshi 河野寛