TSUYAMA TOMONORI 津山友徳

Researcher Number	10845960
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 熊本大学, 大学院生命科学研究部(医), 助教 2020 – 2021: 熊本大学, 大学院生命科学研究部(医), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 膵β細胞 / 低酸素 / β細胞 / 老化 / 転写抑制 / ミトコンドリア / インスリン分泌 / 糖尿病 Except Principal Investigator 糖尿病 / サーチュイン … More / 糖代謝 / シングルセル解析 / エピゲノム / インスリン分泌 / β細胞 / 老化 / FGF21 / 寿命 / IMP2 / 褐色脂肪細胞 / 糖新生 / SIRT7 Less

サーチュイン7（SIRT7）による糖代謝制御の統合的理解とその制御法の開発
- Principal Investigator
  
  山縣和也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
加齢による膵β細胞個性喪失の分子機構の解明Principal Investigator
- Principal Investigator
  
  津山友徳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Elucidation of molecular mechanism of age-associated impaired insulin secretion by single cell analysis
- Principal Investigator
  
  山縣和也
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University
Hypoxic response by BHLHE40 and PHD3 in pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  Tsuyama Tomonori
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Regulation of glucose metabolism by SIRT7
- Principal Investigator
  
  山縣和也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
The role of PHD3 in hypoxic response of pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  TSUYAMA TOMONORI
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University

All 2024 2023 2022 2020

All Journal Article Presentation

[Journal Article] Roles of β-Cell Hypoxia in the Progression of Type 2 Diabetes2024
- Author(s)
  Yamagata Kazuya、Tsuyama Tomonori、Sato Yoshifumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 8 Pages: 4186-4186
- DOI
  10.3390/ijms25084186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18302, KAKENHI-PROJECT-23K24388
[Journal Article] Hypoxia causes pancreatic β‐cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE402023
- Author(s)
  Tsuyama Tomonori、Sato Yoshifumi、Yoshizawa Tatsuya、Matsuoka Takaaki、Yamagata Kazuya
- Journal Title
  
  EMBO reports
  
  Volume: 24 Issue: 8
- DOI
  10.15252/embr.202256227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18302, KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K24388
[Journal Article] SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice2022
- Author(s)
  Mizumoto Tomoya、Yoshizawa Tatsuya、Sato Yoshifumi、Ito Takaaki、Tsuyama Tomonori、Satoh Akiko、Araki Satoshi、Tsujita Kenichi、Tamura Masaru、Oike Yuichi、Yamagata Kazuya
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 22 Pages: 3609-3609
- DOI
  10.3390/cells11223609
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H04107, KAKENHI-PROJECT-23K24388, KAKENHI-PROJECT-23K24805
[Journal Article] SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice2022
- Author(s)
  Yoshizawa Tatsuya、Sato Yoshifumi、Sobuz Shihab U.、Mizumoto Tomoya、Tsuyama Tomonori、Karim Md. Fazlul、Miyata Keishi、Tasaki Masayoshi、Yamazaki Masaya、Kariba Yuichi、Araki Norie、Araki Eiichi、Kajimura Shingo、Oike Yuichi、Braun Thomas、Bober Eva、Auwerx Johan、Yamagata Kazuya
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7439-7439
- DOI
  10.1038/s41467-022-35219-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08533, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H04107, KAKENHI-PROJECT-23K24388, KAKENHI-PROJECT-19H03772, KAKENHI-PROJECT-22F22111
[Journal Article] Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes2020
- Author(s)
  Kariba Yuichi、Yoshizawa Tatsuya、Sato Yoshifumi、Tsuyama Tomonori、Araki Eiichi、Yamagata Kazuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Issue: 3 Pages: 500-507
- DOI
  10.1016/j.bbrc.2020.05.090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-20K17538, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-16H06276
[Journal Article] HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT12020
- Author(s)
  Sato Yoshifumi、Rahman Md Mostafizur、Haneda Masaki、Tsuyama Tomonori、Mizumoto Tomoya、Yoshizawa Tatsuya、Kitamura Tadahiro、Gonzalez Frank J.、Yamamura Ken-ichi、Yamagata Kazuya
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1866 Issue: 11 Pages: 165898-165898
- DOI
  10.1016/j.bbadis.2020.165898
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-20K17538, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-16H06276
[Presentation] 低酸素誘導性インスリン分泌不全の分子機構の解明2023
- Author(s)
  津山友徳、佐藤叔史、松岡孝昭、山縣和也
- Organizer
  第６１回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-23K18302
[Presentation] 脱アセチル化酵素SIRT7による肝糖新生制御機構の解明2023
- Author(s)
  水本智也、佐藤叔史、津山友徳、山縣和也
- Organizer
  第６１回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-23K18302
[Presentation] 膵β細胞における低酸素誘導因子ATF3の役割2023
- Author(s)
  佐藤叔史、津山友徳、山縣和也
- Organizer
  第６１回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-23K24388
[Presentation] 低酸素誘導性インスリン分泌不全の分子機構の解明2023
- Author(s)
  津山友徳、佐藤叔史、松岡孝昭、山縣和也
- Organizer
  第６１回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-23K24388
[Presentation] 脱アセチル化酵素SIRT7による肝糖新生制御機構の解明2023
- Author(s)
  水本智也、佐藤叔史、津山友徳、山縣和也
- Organizer
  第６１回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-23K24388
[Presentation] 低酸素誘導性インスリン分泌不全の分子機構の解明2023
- Author(s)
  津山友徳
- Organizer
  第61回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-22K16399
[Presentation] 膵β細胞における低酸素誘導因子ATF3の役割2023
- Author(s)
  佐藤叔史、津山友徳、山縣和也
- Organizer
  第６１回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-23K18302
[Presentation] 日本人の加齢による２型糖尿病発症機序の解明（合志スタディ）2023
- Author(s)
  羽根田昌樹、福田一起、宮川克俊、清原由紀夫、古賀荒太郎、水流添　覚、古川昇、津山友徳、阪口雅司、瀬ノ口隆文、松村剛、山縣和也、荒木栄一
- Organizer
  第６６回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K24388

1. 山縣和也 (70324770)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 佐藤叔史 (90622598)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. 吉澤達也 (40313530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 水本智也 (10985427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 荒木栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUYAMA TOMONORI 津山 友徳

Research Projects

Research Products

Co-Researchers

サーチュイン7（SIRT7）による糖代謝制御の統合的理解とその制御法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢による膵β細胞個性喪失の分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanism of age-associated impaired insulin secretion by single cell analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Hypoxic response by BHLHE40 and PHD3 in pancreatic beta cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of glucose metabolism by SIRT7

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of PHD3 in hypoxic response of pancreatic beta cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Roles of β-Cell Hypoxia in the Progression of Type 2 Diabetes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxia causes pancreatic β‐cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE402023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT12020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 低酸素誘導性インスリン分泌不全の分子機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] 脱アセチル化酵素SIRT7による肝糖新生制御機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] 膵β細胞における低酸素誘導因子ATF3の役割2023

Author(s)

TSUYAMA TOMONORI 津山友徳