Okada Hiroyuki 岡田寛之

Researcher Number	10883481
Other IDs
Affiliation (Current)	2023: 東京大学, 大学院医学系研究科(医学部), 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 東京大学, 大学院医学系研究科(医学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / 0906:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Medium-sized Section 57:Oral science and related fields / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 破骨細胞 / 1細胞解析 / 1細胞内解析 / シングルセル / 多核巨細胞 / シングルセル解析 / 転写制御 / 異物反応 / 異物巨細胞 / ヒト … More / バイオインプラント / 次世代シーケンサー / 骨代謝 / 骨免疫 … More Except Principal Investigator 臍帯組織 / 次世代シーケンサー / エピゲノム解析 / CRISPR / エンハンサー / 一細胞CRISPRスクリーニング / SNP / 組織リモデリング / 骨欠損 / 骨再生 / バイオマテリアル Less

Gene Regulatory Nework Analysis within lving single cell including osteoclastPrincipal Investigator
- Principal Investigator
  
  岡田寛之
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Evaluation of properties by epigenome analysis for human umbilical cord-derived stromal cells and research for bone regenerative medicine
- Principal Investigator
  
  金澤三四朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The University of Tokyo
Intra-single cell analysis clarifies the mechanism of bone remodeling and improves prognosis of hip fracturesPrincipal Investigator
- Principal Investigator
  
  岡田寛之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
一細胞CRISPRスクリーニング法を駆使した機能的GWAS-SNP検出法の確立
- Principal Investigator
  
  北條宏徳
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  The University of Tokyo
組織リモデリングの理解に基づく骨再生法の開発
- Principal Investigator
  
  鄭雄一
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Development of bioimplant modulating both inflammation and fibrosis in HumanPrincipal Investigator
- Principal Investigator
  
  岡田寛之
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  The University of Tokyo
Differentiation Mechanism of Osteoclast revealed by single cell and 3D structure analysisPrincipal Investigator
- Principal Investigator
  
  Okada Hiroyuki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0906:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin‐Dependent Kinase Inhibitors2022
- Author(s)
  Watanabe Hisato、Okada Hiroyuki、Hirose Jun、Omata Yasunori、Matsumoto Takumi、Matsumoto Morio、Nakamura Masaya、Saito Taku、Miyamoto Takeshi、Tanaka Sakae
- Journal Title
  
  JBMR Plus
  
  Volume: 6 Issue: 4
- DOI
  10.1002/jbm4.10608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08246, KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-21K16703
[Journal Article] Plasmalemmal interface for calcium signaling in osteoclast differentiation2022
- Author(s)
  Okada Hiroyuki、Tanaka Sakae
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 74 Pages: 55-61
- DOI
  10.1016/j.ceb.2022.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20473, KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-21K16703
[Journal Article] Mesenchymal stromal cells in the bone marrow niche consist of multi-populations with distinct transcriptional and epigenetic properties2021
- Author(s)
  Kanazawa Sanshiro、Okada Hiroyuki、Hojo Hironori、Ohba Shinsuke、Iwata Junichi、Komura Makoto、Hikita Atsuhiko、Hoshi Kazuto
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15811-15811
- DOI
  10.1038/s41598-021-94186-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-17H04403, KAKENHI-PROJECT-21H04952, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-21H03142, KAKENHI-PROJECT-17K11932, KAKENHI-PROJECT-21K19589, KAKENHI-PROJECT-21K19883, KAKENHI-PROJECT-21K16703
[Journal Article] The Progress of Stem Cell Technology for Skeletal Regeneration2021
- Author(s)
  Tani Shoichiro、Okada Hiroyuki、Chung Ung-il、Ohba Shinsuke、Hojo Hironori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 3 Pages: 1404-1404
- DOI
  10.3390/ijms22031404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06312, KAKENHI-PROJECT-18H02998, KAKENHI-PROJECT-18K19635, KAKENHI-PROJECT-18K19636, KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-17H04403, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-21K16703
[Journal Article] Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone Resorption2020
- Author(s)
  Okada Hiroyuki、Okabe Koji、Tanaka Sakae
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 1 Pages: 180-180
- DOI
  10.3390/ijms22010180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22973, KAKENHI-PROJECT-19H03822, KAKENHI-PROJECT-18K09017
[Presentation] single cell Bone Milieu Atlas作成とその利活用2022
- Author(s)
  岡田寛之、谷彰一郎、小俣康徳、寺島明日香、矢野文子*3、斎藤琢*2、田中栄*2、鄭雄一*1、北條宏徳*1
- Organizer
  第6回日本骨免疫学会ウィンタースクール
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] single cell Bone Milieu Atlas作成とその利活用2022
- Author(s)
  岡田寛之、谷彰一郎、小俣康徳、寺島明日香、矢野文子、斎藤琢、田中栄、鄭雄一、北條宏徳
- Organizer
  第6回日本骨免疫学会ウィンタースクール
- Data Source
  KAKENHI-PROJECT-21K16703
[Presentation] RANKLとITAMが生み出す破骨細胞のカルシウムハーモニー2021
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] 1細胞レベルで理解する骨の生理・病理2021
- Author(s)
  岡田寛之, 鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  福岡歯科大学口腔医学研究センターシンポジウム「口腔医学研究のRising Sunに出会う」
- Invited
- Data Source
  KAKENHI-PROJECT-21K16703
[Presentation] Atlas of murine bone milieu provides insights into cell-cell interaction between osteoclast, osteoblast, and osteocyte in bone remodeling2021
- Author(s)
  Hiroyuki Okada, Shoichiro Tani, Mika Nakayama, Dahlia Eldeeb, Yasunori Omata, Fumiko Yano, Taku Saito, Sakae Tanaka, Shinsuke Ohba, Ung-il Chung, Hironori Hojo
- Organizer
  ASBMR (American Society for Bone and Mineral Research) 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16703
[Presentation] 1細胞レベルで理解する骨の生理・病理2021
- Author(s)
  岡田寛之, 鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  福岡歯科大学口腔医学研究センターシンポジウム「口腔医学研究のRising Sunに出会う」
- Invited
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] 破骨細胞分化におけるカルシウム振動制御の妙2021
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  第18回 Osteoimmunology Forum
- Invited
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] RANKLとITAMが生み出す破骨細胞のカルシウムハーモニー2021
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-21K16703
[Presentation] 数理モデルが解き明かす破骨細胞分化における細胞内カルシウム動態 - CTLA4-Igの骨破壊抑制機序を含めて2021
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  第39回日本骨代謝学会　日本リウマチ学会合同シンポジウム「関節リウマチにおける関節破壊機序」
- Invited
- Data Source
  KAKENHI-PROJECT-21K16703
[Presentation] EXPLORING HUMAN SKELETAL DEVELOPMENT USING AN INDUCED HUMAN BONE TISSUE DERIVED FROM HUMAN PLURIPOTENT STEM CELLS2021
- Author(s)
  Shoichiro Tani, Hiroyuki Okada, Masahide Seki, Yutaka Suzuki, Ung-il Chung, Hironori Hojo and Shinsuke Ohba
- Organizer
  ISSCR 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19883
[Presentation] Understanding a Mechanism Underlying Bone Repair Process by Combinational Analysis of Lineage Tracing and Single-Cell RNA Sequencing2021
- Author(s)
  Mika Nakayama, Hiroyuki Okada, Masahide Seki, Yutaka Suzuki, Ung-il Chung, Shinsuke Ohba, Hironori Hojo
- Organizer
  ISSCR 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19883
[Presentation] Frequency and amplitude analyses of calcium oscillations reveals the harmony regulated by ITAM receptors during RANKL-induced osteoclastogenesis2021
- Author(s)
  Hiroyuki Okada, Hiroshi Kajiya, Yasunori Omata, Hironori Hojo, Ung-il Chung, Koji Okabe, Takeshi Miyamoto, Sakae Tanaka
- Organizer
  ECTS (european calcified tissue society) 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16703
[Presentation] Frequency and amplitude analyses of calcium oscillations reveals the harmony regulated by ITAM receptors during RANKL-induced osteoclastogenesis2021
- Author(s)
  Hiroyuki Okada, Hiroshi Kajiya, Yasunori Omata, Hironori Hojo, Ung-il Chung, Koji Okabe, Takeshi Miyamoto, Sakae Tanaka
- Organizer
  ECTS (european calcified tissue society) 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] Atlas of murine bone milieu provides insights into cell-cell interaction between osteoclast, osteoblast, and osteocyte in bone remodeling2021
- Author(s)
  Hiroyuki Okada, Shoichiro Tani, Mika Nakayama, Dahlia Eldeeb, Yasunori Omata, Fumiko Yano, Taku Saito, Sakae Tanaka, Shinsuke Ohba, Ung-il Chung, Hironori Hojo
- Organizer
  ASBMR (American Society for Bone and Mineral Research) 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] 数理モデルが解き明かす破骨細胞分化に必須な共刺激2021
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] 数理モデルが解き明かす破骨細胞分化に必須な共刺激2021
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K16703
[Presentation] 数理モデルが解き明かす破骨細胞分化における細胞内カルシウム動態 - CTLA4-Igの骨破壊抑制機序を含めて2021
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、北條宏徳、鄭雄一、岡部幸司、宮本健史、田中栄
- Organizer
  第39回日本骨代謝学会　日本リウマチ学会合同シンポジウム「関節リウマチにおける関節破壊機序」
- Invited
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] 破骨細胞分化初期の共刺激-カルシウムオシレーション-NFATc1 軸 ~特に共刺激周囲の補因子について2020
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、岡部幸司、宮本健史、田中栄
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] Dectin-2, a Fc receptor gamma-harboring receptor, regulates foreign body reaction by interfering with intracellular calcium oscillation.2020
- Author(s)
  Hiroyuki Okada, Hiroshi Kajiya, Yasunori Omata, Koji Okabe, Takeshi Miyamoto, Sakae Tanaka
- Organizer
  ASBMR 2020 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22973
[Presentation] Dectin-2はFcRγと会合し、カルシウム振動に干渉し異物反応を制御する2020
- Author(s)
  岡田寛之、鍛治屋浩、小俣康徳、岡部幸司、宮本健史、田中栄
- Organizer
  第38回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-20K22973

1. 北條宏徳 (80788422)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 大庭伸介 (20466733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 金澤三四朗 (60823466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 長村登紀子 (70240736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 関真秀 (90749326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鄭雄一 (30345053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 酒井崇匡 (70456151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAITO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 田中栄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岡田慶太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okada Hiroyuki 岡田 寛之

Research Projects

Research Products

Co-Researchers

Gene Regulatory Nework Analysis within lving single cell including osteoclastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of properties by epigenome analysis for human umbilical cord-derived stromal cells and research for bone regenerative medicine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intra-single cell analysis clarifies the mechanism of bone remodeling and improves prognosis of hip fracturesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

一細胞CRISPRスクリーニング法を駆使した機能的GWAS-SNP検出法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

組織リモデリングの理解に基づく骨再生法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of bioimplant modulating both inflammation and fibrosis in HumanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differentiation Mechanism of Osteoclast revealed by single cell and 3D structure analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin‐Dependent Kinase Inhibitors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasmalemmal interface for calcium signaling in osteoclast differentiation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal stromal cells in the bone marrow niche consist of multi-populations with distinct transcriptional and epigenetic properties2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Progress of Stem Cell Technology for Skeletal Regeneration2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone Resorption2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] single cell Bone Milieu Atlas作成とその利活用2022

Author(s)

Organizer

Data Source

[Presentation] single cell Bone Milieu Atlas作成とその利活用2022

Author(s)

Organizer

Data Source

[Presentation] RANKLとITAMが生み出す破骨細胞のカルシウムハーモニー2021

Okada Hiroyuki 岡田寛之