Ishida Ryosuke 石田良典

Researcher Number	10937684
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(薬学), 助教 2025: 東京科学大学, 総合研究院, 助教
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京医科歯科大学, 生体材料工学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Basic Section 47040:Pharmacology-related / Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator チャネル開閉ダイナミズム / 筋疾患 / カルシウムチャネル / リアノジン受容体制御剤 / 構造活性相関 / 筋細胞異常 / リアノジン受容体 Except Principal Investigator 神経変性疾患 / ライブセルイメージング / Gタンパク質共役型受容体 … More / シグナル伝達 / シナプス / 超複合体 / 膜タンパク質 / GPCR / タンパク質ータンパク質相互作用阻害剤 / ファオルダマー / 大環状化合物 / らせん分子 / 環状構造 / らせん構造 / フォルダマー / 芳香族アミド / 創薬 / 心筋 / 機能抑制型変異 / カルシウム / 抗不整脈薬 / 不整脈 / 2型リアノジン受容体 Less

New molecular shapes from strained aromatic foldamer macrocycles and their application to development of PPI inhibitors
- Principal Investigator
  
  棚谷綾
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Ochanomizu University
Manipulation of membrane protein supercomplexes to elucidate their molecular dynamics and function
- Principal Investigator
  
  上窪裕二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Juntendo University
Development of RyR2-specific inhibitors and activators and their application as antiarrhythmic agents
- Principal Investigator
  
  呉林なごみ
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Juntendo University
Development of chemical toolbox for RyR regulator and analysis of the dynamism of RyR open/close mechanismPrincipal Investigator
- Principal Investigator
  
  Ishida Ryosuke
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Discovery and Structure–Activity Relationship of a Ryanodine Receptor 2 Inhibitor2024
- Author(s)
  Ryosuke Ishida, Xi Zeng, Nagomi Kurebayashi, Takashi Murayama, Shuichi Mori, Hiroyuki Kagechika
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 4 Pages: 399-407
- DOI
  10.1248/cpb.c24-00114
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-04-22
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15244
[Journal Article] Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca<sup>2+</sup>Monitoring2023
- Author(s)
  Takenaka Mai、Kodama Masami、Murayama Takashi、Ishigami-Yuasa Mari、Mori Shuichi、Ishida Ryosuke、Suzuki Junji、Kanemaru Kazunori、Sugihara Masami、Iino Masamitsu、Miura Aya、Nishio Hajime、Morimoto Sachio、Kagechika Hiroyuki、Sakurai Takashi、Kurebayashi Nagomi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 104 Issue: 6 Pages: 275-286
- DOI
  10.1124/molpharm.123.000720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652
[Journal Article] Drug development for the treatment of RyR1-related skeletal muscle diseases2023
- Author(s)
  Takashi Murayama, Nagomi Kurebayashi, Ryosuke Ishida, Hiroyuki Kagechika
- Journal Title
  
  Current Opinion in Pharmacology
  
  Volume: 69 Pages: 102356-102356
- DOI
  10.1016/j.coph.2023.102356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15244, KAKENHI-PROJECT-22K06652
[Journal Article] A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment2023
- Author(s)
  Ishida Ryosuke、Kurebayashi Nagomi、Iinuma Hiroto、Zeng Xi、Mori Shuichi、Kodama Masami、Murayama Takashi、Masuno Hiroyuki、Takeda Fumi、Kawahata Masatoshi、Tanatani Aya、Miura Aya、Nishio Hajime、Sakurai Takashi、Kagechika Hiroyuki
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 262 Pages: 115910-115910
- DOI
  10.1016/j.ejmech.2023.115910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-22K15244
[Journal Article] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery2022
- Author(s)
  Murayama Takashi、Kurebayashi Nagomi、Numaga-Tomita Takuro、Kobayashi Takuya、Okazaki Satoru、Yamashiro Kyosuke、Nakada Tsutomu、Mori Shuichi、Ishida Ryosuke、Kagechika Hiroyuki、Yamada Mitsuhiko、Sakurai Takashi
- Journal Title
  
  Journal of General Physiology
  
  Volume: 154 Issue: 12
- DOI
  10.1085/jgp.202213230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-22K06828, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Journal Article] Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes2022
- Author(s)
  Tsuboi Yoshitaka、Oyama Kotaro、Kobirumaki-Shimozawa Fuyu、Murayama Takashi、Kurebayashi Nagomi、Tachibana Toshiaki、Manome Yoshinobu、Kikuchi Emi、Noguchi Satoru、Inoue Takayoshi、Inoue Yukiko U.、Nishino Ichizo、Mori Shuichi、Ishida Ryosuke、Kagechika Hiroyuki、Suzuki Madoka、Fukuda Norio、Yamazawa Toshiko
- Journal Title
  
  Journal of General Physiology
  
  Volume: 154 Issue: 11
- DOI
  10.1085/jgp.202213136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06789, KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-21K19929, KAKENHI-PLANNED-22H05053, KAKENHI-PLANNED-22H05054, KAKENHI-PLANNED-22H05055, KAKENHI-PROJECT-20H03421, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24778, KAKENHI-PROJECT-23K24067
[Journal Article] Development of a water-soluble ryanodine receptor 1 inhibitor2022
- Author(s)
  Ishida Ryosuke、Mori Shuichi、Murayama Takashi、Nakamichi Ayaka、Chai Xikun、Kurebayashi Nagomi、Iinuma Hiroto、Kagechika Hiroyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 74 Pages: 117027-117027
- DOI
  10.1016/j.bmc.2022.117027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-22K15244, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Presentation] A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment2024
- Author(s)
  Xi Zeng, Ryosuke Ishida, Nagomi Kurebayashi, Hiroto Iinuma, Masami Kodama, Takashi Murayama, Hiroyuki Kagechika
- Organizer
  24th Tetrahedron Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15244
[Presentation] 不整脈治療への展開を指向した新規2型リアノジン受容体選択的阻害剤の開発2023
- Author(s)
  石田良典、曾　希、森　修一、呉林なごみ、児玉昌美、飯沼大翔、村山　尚、影近弘之
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-22K15244
[Presentation] 海馬スライス培養を用いたアミロイドプラーク形成と神経突起変性の経時的解析2023
- Author(s)
  周藝瑶, 上窪裕二, 石田葉子, 日置寛之, 櫻井隆
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06170
[Presentation] 水溶性向上を意図した RyR1 阻害剤の構造展開および結合位置特定のためのプローブ化2022
- Author(s)
  石田良典、森修一、飯沼大翔、柴喜坤、村山尚、呉林なごみ、影近弘之
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K15244
[Presentation] 不整脈を引き起こす変異型RyR2新規阻害剤の開発2022
- Author(s)
  曾　希、石田良典、呉林なごみ、村山　尚、山本優雅、森　修一、影近弘之
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K15244

1. 呉林なごみ (50133335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 小川治夫 (40292726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 杉原匡美 (80648163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 棚谷綾 (40361654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 影近弘之 (20177348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大金賢司 (30771092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 桑原拓也 (60768654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 上窪裕二 (80509670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 国広なごみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 小比類巻生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishida Ryosuke 石田 良典

Research Projects

Research Products

Co-Researchers

New molecular shapes from strained aromatic foldamer macrocycles and their application to development of PPI inhibitors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Manipulation of membrane protein supercomplexes to elucidate their molecular dynamics and function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of RyR2-specific inhibitors and activators and their application as antiarrhythmic agents

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of chemical toolbox for RyR regulator and analysis of the dynamism of RyR open/close mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Discovery and Structure–Activity Relationship of a Ryanodine Receptor 2 Inhibitor2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca<sup>2+</sup>Monitoring2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug development for the treatment of RyR1-related skeletal muscle diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a water-soluble ryanodine receptor 1 inhibitor2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment2024

Author(s)

Organizer

Data Source

[Presentation] 不整脈治療への展開を指向した新規2型リアノジン受容体選択的阻害剤の開発2023

Author(s)

Organizer

Data Source

[Presentation] 海馬スライス培養を用いたアミロイドプラーク形成と神経突起変性の経時的解析2023

Author(s)

Organizer

Data Source

[Presentation] 水溶性向上を意図した RyR1 阻害剤の構造展開 および結合位置特定のためのプローブ化2022

Author(s)

Ishida Ryosuke 石田良典

[Presentation] 水溶性向上を意図した RyR1 阻害剤の構造展開および結合位置特定のためのプローブ化2022