ka chihou 何治鋒

… Alternative Names

He Zhifeng 何治鋒

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Researcher Number	10980047
Affiliation (Current)	2026: 松本歯科大学, 総合歯科医学研究所, 助教
Affiliation (based on the past Project Information) *help	2023 – 2026: 松本歯科大学, 総合歯科医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 57010:Oral biological science-related / 0907:Oral science and related fields Except Principal Investigator Basic Section 57040:Regenerative dentistry and dental engineering-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator Macrophage / Wnt signal / bone repair / macrophage / Neutrophil / Bone repair / csf1r / tissue regeneration / neutrophil Except Principal Investigator 骨粗鬆症 … More / Siglec-15 / Siglec15抗体 / RNA-Seq / RANKL / M-CSF / Siglec15 / 骨代謝カップリング / 骨芽細胞 / 破骨細胞 / 細胞老化 / Wnt / ニッチ / 骨再生 / インフラマエイジング / 老化細胞 Less

Identification of a senescent macrophage-adipocyte niche impairing hematopoiesis and bone regeneration.Principal Investigator
- Principal Investigator
  
  何治鋒
- Project Period (FY)
  2026 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Matsumoto Dental University
インフラマエイジングによる骨再生ニッチ破綻機構の解明と老化骨組織再生法の開発
- Principal Investigator
  
  小林泰浩
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Matsumoto Dental University
新規Siglec-15陽性マクロファージによる骨再生分子機構の解明と骨組織再生戦略
- Principal Investigator
  
  宇田川信之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Matsumoto Dental University
Identification a novel bone-generating macrophage subset and their molecular mechanisms.Principal Investigator
- Principal Investigator
  
  何治鋒
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Matsumoto Dental University
Identification of new macrophage populations promoting bone regeneration.Principal Investigator
- Principal Investigator
  
  He Zhifeng
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Matsumoto Dental University

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] Vitamin D receptor in osteoblast lineage cells mediates increased sclerostin circulation and decreased bone formation in hypervitaminosis D2025
- Author(s)
  Liu Ziyang、He Zhifeng、Shi Linan、Mori Tomoki、Tamamura Yoshihiro、Udagawa Nobuyuki、Nakamichi Yuko
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 249 Pages: 106711-106711
- DOI
  10.1016/j.jsbmb.2025.106711
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0234, KAKENHI-PROJECT-24K02618, KAKENHI-PROJECT-24K02629, KAKENHI-PROJECT-23K18368, KAKENHI-PROJECT-24K22197
[Journal Article] Effects of Diode Laser Irradiation on Bone Formation in the Tibiae of Estrogen-deficient Rats2025
- Author(s)
  FURUKAWA TOSHIKO、KAWANO MUNEMITSU、YOKOSE SATOSHI、IWAMOTO RINA、UDAGAWA NOBUYUKI
- Journal Title
  
  In Vivo
  
  Volume: 39 Issue: 2 Pages: 634-639
- DOI
  10.21873/invivo.13868
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10020, KAKENHI-PROJECT-24K02629, KAKENHI-PROJECT-24K22197
[Journal Article] Osteoprotegerin secretion and its inhibition by RANKL in osteoblastic cells visualized using bioluminescence imaging2025
- Author(s)
  Ninomiya Hotsuna、Fukuda Shinji、Nishida-Fukuda Hisayo、Shibata Yuto、Sato Takuma、Nakamichi Yuko、Nakamura Midori、Udagawa Nobuyuki、Miyazawa Ken、Suzuki Takahiro
- Journal Title
  
  Bone
  
  Volume: 191 Pages: 117319-117319
- DOI
  10.1016/j.bone.2024.117319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09864, KAKENHI-PROJECT-22K10282, KAKENHI-PROJECT-19KK0234, KAKENHI-PROJECT-24K02618, KAKENHI-PROJECT-24K02629, KAKENHI-PROJECT-23K05686, KAKENHI-PROJECT-24K11730, KAKENHI-PROJECT-23K18368, KAKENHI-PROJECT-24K22197
[Journal Article] Association Between the Bone Density of Alveolar and General Skeletal Bones in the Young2025
- Author(s)
  Sugino Noriyuki、Kuroiwa Hiroko、Osanai Hizuru、Yamada Shinichiro、Dewake Nanae、Suzuki Souhei、Kawahara Yoshimi、Yoshinari Nobuo、Udagawa Nobuyuki、Taguchi Akira
- Journal Title
  
  Cureus
  
  Volume: 17
- DOI
  10.7759/cureus.78643
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10208, KAKENHI-PROJECT-24K02629, KAKENHI-PROJECT-24K22197
[Journal Article] Difference in Bone Density in Young Women With Normal Occlusion and Malocclusion2025
- Author(s)
  Hatori Haruka、Udagawa Nobuyuki、Yoshinari Nobuo、Uenishi Kazuhiro、Sugino Noriyuki、Taguchi Akira
- Journal Title
  
  Cureus
  
  Volume: 17
- DOI
  10.7759/cureus.79731
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10208, KAKENHI-PROJECT-24K02629, KAKENHI-PROJECT-24K22197
[Journal Article] Wnt family members regulating osteogenesis and their origins2024
- Author(s)
  Kobayashi Yasuhiro、Iwamoto Rina、He Zhifeng、Udagawa Nobuyuki
- Journal Title
  
  Journal of Bone and Mineral Metabolism
  
  Volume: 43 Issue: 1 Pages: 39-45
- DOI
  10.1007/s00774-024-01554-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00653, KAKENHI-PROJECT-24K02629, KAKENHI-PROJECT-22K18402, KAKENHI-PROJECT-24K22197
[Journal Article] The G9a histone methyltransferase represses osteoclastogenesis and bone resorption by regulating NFATc1 function2024
- Author(s)
  Komatsu Koichiro、Ideno Hisashi、Nakashima Kazuhisa、Udagawa Nobuyuki、Kobayashi Yasuhiro、Kimura Hiroshi、Tachibana Makoto、Yamashita Teruhito、Nifuji Akira
- Journal Title
  
  The FASEB Journal
  
  Volume: 38 Issue: 13 Pages: 1-14
- DOI
  10.1096/fj.202400449rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09914, KAKENHI-PROJECT-24K02629, KAKENHI-PROJECT-21K09823, KAKENHI-PROJECT-22K18402, KAKENHI-PROJECT-24K22197
[Presentation] 老化間葉系幹細胞はcGAS-STING 経路を介してDkk1 を分泌し骨芽細胞分化を抑制する2024
- Author(s)
  石田昌義、岩本莉奈、高橋拓実、何治鋒、宇田川信之、小林泰浩
- Organizer
  第8回日本骨免疫学会冬期学術集会
- Data Source
  KAKENHI-PROJECT-24K02629
[Presentation] A novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2024
- Author(s)
  何　治鋒
- Organizer
  歯科基礎学会学術大会（第66回）
- Invited
- Data Source
  KAKENHI-PROJECT-23K19731
[Presentation] VDR IN OSTEOBLASTIC CELLS DICTATES DISEASE OUTCOMES OF CALCIUM AND PHOSPHATE METABOLIC DISORDERS2024
- Author(s)
  Ziyang Liu, Zhifeng He, Linan Shi, Nobuyuki Udagawa, Yuko Nakamichi
- Organizer
  25th Vitamin D Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02629
[Presentation] 老化間葉系幹細胞はcGAS-STING経路によりWnt-β-カテニン阻害因子を分泌し骨芽細胞分化を抑制する2024
- Author(s)
  石田昌義、岩本莉奈、何治鋒、宇田川信之、小林泰浩
- Organizer
  日本骨代謝学会学術集会（第42回）
- Data Source
  KAKENHI-PROJECT-24K02629
[Presentation] The Vitamin D Receptor (VDR) in Osteoblastic Cells Dictates Disease Outcomes of Calcium and Phosphate Metabolic Disorders2024
- Author(s)
  Yuko Nakamichi, Ziyang Liu, Zhifeng He, Linan Shi, Nobuyuki Udagawa
- Organizer
  アメリカ骨代謝学会 (ASBMR) 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02629
[Presentation] 血管内皮細胞RANKは加齢に伴う骨喪失及び骨髄の老化表現型に寄与する2024
- Author(s)
  岩本莉奈、高橋拓実、石田昌義、何治鋒、宇田川信之、小林泰浩
- Organizer
  第8回日本骨免疫学会冬期学術集会
- Data Source
  KAKENHI-PROJECT-24K02629
[Presentation] A novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2024
- Author(s)
  Zhifeng He, Linan Shi, Toshihide Mizoguchi, Ruoxuan Li, Yuki Matsushita, Shinichiro Ito, Yuko Nakamichi, Kohei Murakami, Kazuo Okamoto, Hiroshi Takayanagi, Nobuyuki Udagawa, and Yasuhiro Kobayashi
- Organizer
  第9回国際骨免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02629
[Presentation] A novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2024
- Author(s)
  何　治鋒
- Organizer
  第9回国際骨免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K19848
[Presentation] A novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2024
- Author(s)
  Zhifeng He, Linan Shi, Toshihide Mizoguchi, Ruoxuan Li, Yuki Matsushita, Shinichiro Ito, Yuko Nakamichi, Kohei Murakami, Kazuo Okamoto, Hiroshi Takayanagi, Nobuyuki Udagawa, and Yasuhiro Kobayashi
- Organizer
  9th International Conference on Osteoimmunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24H00653
[Presentation] A novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2024
- Author(s)
  何　治鋒
- Organizer
  歯科基礎学会学術大会（第66回）
- Invited
- Data Source
  KAKENHI-PROJECT-24K19848
[Presentation] 血管による骨・石灰化制御」骨の老化における血管内皮細胞RANKの役割2024
- Author(s)
  岩本莉奈，高橋拓実，何治鋒, 石田昌義, 中村美どり, 宇田川信之, 小林泰浩
- Organizer
  第42回日本骨代謝学会学術集会シンポジウム6 「血管による骨・石灰化制御」
- Invited
- Data Source
  KAKENHI-PROJECT-24H00653
[Presentation] novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2024
- Author(s)
  何　治鋒
- Organizer
  第9回国際骨免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19731
[Presentation] A macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2023
- Author(s)
  Zhifeng He
- Organizer
  第８回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-23K19731
[Presentation] F4/80(+); Csf1r(-)マクロファージは LepR(+)細胞を活性化し、骨再生を促進する2023
- Author(s)
  何　治鋒
- Organizer
  第95回松本歯科大学学会
- Data Source
  KAKENHI-PROJECT-23K19731
[Presentation] A macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2023
- Author(s)
  Zhifeng He
- Organizer
  第５回オーラルサイエンス研究会
- Data Source
  KAKENHI-PROJECT-23K19731

1. 小林泰浩 (20264252)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 宇田川信之 (70245801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. 石田昌義 (50643251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 塚崎雅之 (20829527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 岩本莉奈 (20907216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 前川知樹 (50625168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 溝口利英 (90329475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 小出雅則 (10367617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中村浩彰 (50227930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中村美どり (90278177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 上原俊介 (90434480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUKUDA SHINJI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 中道裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小松浩一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 出野尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 中島和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 二藤彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 横瀬敏志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 鈴木崇弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 吉成伸夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 杉野紀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 田口明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

ka chihou 何 治鋒

He Zhifeng 何 治鋒

Research Projects

Research Products

Co-Researchers

Identification of a senescent macrophage-adipocyte niche impairing hematopoiesis and bone regeneration.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インフラマエイジングによる骨再生ニッチ破綻機構の解明と老化骨組織再生法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規Siglec-15陽性マクロファージによる骨再生分子機構の解明と骨組織再生戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification a novel bone-generating macrophage subset and their molecular mechanisms.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of new macrophage populations promoting bone regeneration.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Vitamin D receptor in osteoblast lineage cells mediates increased sclerostin circulation and decreased bone formation in hypervitaminosis D2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Diode Laser Irradiation on Bone Formation in the Tibiae of Estrogen-deficient Rats2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Osteoprotegerin secretion and its inhibition by RANKL in osteoblastic cells visualized using bioluminescence imaging2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association Between the Bone Density of Alveolar and General Skeletal Bones in the Young2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Difference in Bone Density in Young Women With Normal Occlusion and Malocclusion2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wnt family members regulating osteogenesis and their origins2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The G9a histone methyltransferase represses osteoclastogenesis and bone resorption by regulating NFATc1 function2024

Author(s)

Journal Title

DOI

Data Source

[Presentation] 老化間葉系幹細胞はcGAS-STING 経路を介してDkk1 を分泌し骨芽細胞分化を抑制 する2024

Author(s)

Organizer

Data Source

[Presentation] A novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells2024

Author(s)

Organizer

Data Source

[Presentation] VDR IN OSTEOBLASTIC CELLS DICTATES DISEASE OUTCOMES OF CALCIUM AND PHOSPHATE METABOLIC DISORDERS2024

Author(s)

ka chihou 何治鋒

He Zhifeng 何治鋒

[Presentation] 老化間葉系幹細胞はcGAS-STING 経路を介してDkk1 を分泌し骨芽細胞分化を抑制する2024