NIKI Etsuo 二木鋭雄

Researcher Number	20011033
External Links
Affiliation *help	2016 – 2018 : 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 2008 – 2009 : 独立行政法人産業技術総合研究所, 健康工学研究センター, 顧問 2005 – 2007 : 独立行政法人産業技術総合研究所, ヒューマンストレスシグナル研究センター, センター長 2006 : National Institute of Industrial Science and Technology (AIST), Human Stress Signal Research Center, Director, ヒューマンストレスシグナル研究センター, 研究センター長 1990 – 1999 : 東京大学, 先端科学技術研究センター, 教授 … More
Review Section/Research Field	Principal Investigator 有機工業化学 / 有機工業化学 / Synthetic chemistry Except Principal Investigator 広領域 / Eating habits, studies on eating habits / Circulatory organs internal medicine / Applied health science / 医薬分子機能学 / 医学一般 / 代謝生物化学
Keywords	Principal Investigator ビタミンE / 脂質過酸化 / 自動酸化 / 抗酸化剤 / 抗酸化物 / 低比重リポタンパク / ヒドロペルオキシド / Lipid peroxidation / 化学発光 / トコフェロール … More Except Principal Investigator 抗酸化物質 / LDL / 酸化ストレスマーカー / フリ-ラジカル / 活性酸素 / ヒドロキシリノール酸 / Atherosclerosis / 酸化ストレス / ビタミンE / 動脈硬化 / コレステロール / 活性酸素種 / 酸化DJ-1 / ESR法 / 光酸化反応 / 光増感酸素酸化 / 活性酸素消去酵素 / コエンザイムQ / 脂質過酸化 / Cytokine / 位置選択的水酸化 / Science History and Policy / ブレオマイシン / グルタチオン / 科学文化 / Macrophage / ヒドロペルオキシド / Cholestrol / スカベンジャー受容体 / 消化器疾患 / トコフェリルキノン / 非破壊評価 / Scavenger receptor / tobacco / 創造科学 / 銅ー酸素錯体 / ヒドロキシコレステロール / reactive nitrogen species / 活性窒素種 / Antioxidants / 酸化修飾DJ-1 / Co-culture / スーパーオキシドジスムターゼ / oxidative stress / 特性の融合 / 酸素酸化 / Cell Adhesion / 再灌流 / 混合培養 / 脂質酸化物 / NOラジカル / 機能性食品 / oxidative stress marker / マクロファージ / Lipoprotein / 力学特性 / トコフェロール / 人工ブレオマイシン / 遷移金属錯体触媒 / 複合材料 / 実験動物 / 電極触媒酸素酸化 / オキシゲーゼモデル / パーオキソ錯体 / Creative Science / スーパーオキシド / リノール酸 / Science Culture / 酸素ストレス / 酸素障害 / 酸化 / イソプロスタン / 酸素ラジカル / サイトカイン / プロパンの酸化 / 選択的酸化反応 / SOD / Oxidation / 科学技術 / 日英科学技術史 / 微視構造 / Advanced Inorganic Composites / 和漢薬 / ESR / 無機系複合材料 / 酸素類似反応 / 不斉エポキシ化 / 老化 / 再潅流 / タンパク質酸化修飾 / 損傷 / モノオキシゲナーゼモデル / 繊維 / タバコ / ノックアウトマウス / 神経細胞障害 Less

The study on functional food using oxidative stress marker, hydroxyoctadecadienoic acid and 7-hydroxycholesterol
- Principal Investigator
  
  YOSHIDA Yasukazu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  National Institute of Advanced Industrial Science and Technology
The study on stress induced by tobacco as assessed by oxidative stress marker
- Principal Investigator
  
  YOSHIDA Yasukazu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  National Institute of Advanced Industrial Science and Technology (AIST)
Evaluation of antioxidant activity against atherosclerosis using co-culture system
- Principal Investigator
  
  NOGUCHI Noriko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Research Center for Advanced Science and Technology, University of Tokyo
The Collaboration of International Creative Science and International Science Culture
- Principal Investigator
  
  ENOKI Manabu, 岸輝雄
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  広領域
- Research Institution
  The University of Tokyo
Macrophage scavenger receptors and atherosclerosis
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Research Center for Advanced Sclence and Technology University of Tokyo
Development and Application of Quantitative Evaluation System for Oxidative Damage of LipidsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  有機工業化学
- Research Institution
  The University of Tokyo
Design and Evaluation of Novel Selenium-Containing AntioxidantPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  University of Tokyo
リポ蛋白質の超分子構造と機能Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
フリーラジカルによる細胞の酸化的傷害とその防御機構に関する基礎的研究Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
スーパーオキシド・スーパーオキシドジスムターゼ国際会議開催準備のための総合研究
- Principal Investigator
  
  浅田浩二
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Kyoto University
Development, Design and Evaluation of Novel Natural and Synthetic AntioxidantsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  University of Tokyo, Research Center for Advanced Science and Technology
老化と活性酸素・フリ-ラジカルに関する総合研究
- Principal Investigator
  
  近藤元治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  医学一般
- Research Institution
  Kyoto Prefectural University of Medicine
Synthesis of Aromatic Aldehydes and Carboxylic Acids by the Oxidations of Polyaromatic HydrocarbonsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Research Center for Advanced Science and Technology, The University of Tokyo.
酸素酸化による分子変換
- Principal Investigator
  
  諸岡良彦
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
再灌流時におけるラジカル発生の直接証明
- Principal Investigator
  
  中澤博江
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokai University
Development of Methods for Synthesis of Stereo-Selective Lipid PeroxidesPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Synthetic chemistry
- Research Institution
  UNIVERSITY OF TOKYO
酸素酸化による分子交換
- Principal Investigator
  
  諸岡良彦
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
酸素酸化による分子変換
- Principal Investigator
  
  諸岡良彦
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
A Study on the Action of Antioxidants and Development of SynergistsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  The University of Tokyo
Developments of ultra-sensitive analysis of lipid oxidation and evaluation of antioxidant actibity by chemiluminescencePrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  有機工業化学
- Research Institution
  University of Tokyo
食用油脂類の酸化劣化とその抑制に関する研究Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo

All 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells.2009
- Author(s)
  斉藤芳郎、小川陽子、吉田康一、二木鋭雄
- Journal Title
  
  Journal of Nutritional Biochemistry Vol.20
  
  Pages : 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells.2009
- Author(s)
  斎藤芳郎, 福原明子, 西尾敬子, 早川三恵子, 小川陽子, 坂本Hirokazu, 藤井健志, 吉田康一, 二木鋭雄
- Journal Title
  
  Journal of Nutritional Biochemistry vol.20
  
  Pages : 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients.2009
- Author(s)
  斉藤芳郎、濱窪隆雄、吉田康一、小川陽子、二木鋭雄
- Journal Title
  
  Nurosciencce Letter Vol.463
  
  Pages : 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients2009
- Author(s)
  斎藤芳郎, 濱窪隆雄, 吉田康一, 小川陽子(以下省略10人), 二木鋭雄
- Journal Title
  
  Nuroscience Letters vol463
  
  Pages : 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Gamma-tocopheryl quinine, not alpha-tocopheryl quinine, induces adaptive response through up-regulation of cellular glutathione and cysteine anailability via activation ATF4.2008
- Author(s)
  小川陽子, 斎藤芳郎, 西尾敬子, 吉田康一, 芦田均, 二木鋭雄
- Journal Title
  
  Free Radical Resarch vol.42
  
  Pages : 674-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Acceleration of lipid peroxidation inα-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator.2008
- Author(s)
  吉田康一, 早川三恵子, Cynshi Osamu, Jishage Kou-ichi, 二木鋭雄
- Journal Title
  
  Journal of Oleo Science vol.57
  
  Pages : 577-583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Evaluation of Lipophilic Antioxidant Efficacy in vivo by the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane.2007
- Author(s)
  Yoshida Y, Hayakawa M, Habuchi Y, Itoh N, Niki E.
- Journal Title
  
  Lipids 42
  
  Pages : 463-472
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500495
[Journal Article] Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidativestress induced by selenium deficiency and free radicals2007
- Author(s)
  Saito Y, Yoshida Y, and Niki E
- Journal Title
  
  FEBS Lett 581
  
  Pages : 4349-4354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Cholesterol is more susceptible to oxidation than linolates in cultured cells under oxidative stress induced by selenium deficiebcy and free radicals.2007
- Author(s)
  斎藤芳郎, 吉田康一, 二木鋭雄
- Journal Title
  
  FEBS Letters vol.581
  
  Pages : 4349-4354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Antioxidant effects of 2, 3-dihydro-5-hydroxy-4, 6-di-tert-butyl-2, 2-dipentylbenzofur an and a-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.2007
- Author(s)
  吉田康一, 早川三恵子, 伊藤奈々子, 羽渕洋子, 井上ルリ子, Zhi-Hua Chen, Jiaofei Cao, Cynshi Osamu, Jishage Kou-Ichi, 二木鋭雄
- Journal Title
  
  Biochemical Pharmacology vol.74
  
  Pages : 1010-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio.2006
- Author(s)
  Yoshida Y, Hayakawa M, Habuchi Y, Niki E.
- Journal Title
  
  Biochim. Biophys. Acta. 1760
  
  Pages : 1558-1568
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500495
[Presentation] 酸化DJ-1とパーキンソン病(2)臨床検体の測定2009
- Author(s)
  小川陽子, 斎藤芳郎, 吉田康一, 二木鋭雄
- Organizer
  第62回日本酸化ストレス学会学術総会
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-19300256
[Presentation] 酸化DJ-1とパーキンソン病(1)抗体作成とELISA開発2009
- Author(s)
  斎藤芳郎, 小川陽子, 吉田康一, 二木鋭雄
- Organizer
  第62回日本酸化ストレス学会学術総会
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-19300256

1. YAMAMOTO Yorihiro (60134475)

# of Collaborated Projects : 9results

# of Collaborated Products : 0results
2. NOGUCHI Noriko (40198578)

# of Collaborated Projects : 8results

# of Collaborated Products : 0results
3. 斎藤烈 (20026082)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
4. 諸岡良彦 (70016731)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. 安藤亘 (30008429)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. 杉本豊成 (30093256)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
7. 今中利信 (30029417)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
8. YOSHIDA Yasukazu (90358333)

# of Collaborated Projects : 2results

# of Collaborated Products : 13results
9. ENOKI Manabu (70201960)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. TSUCHIYA Jyunichi (40011051)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. 吉川敏一 (90158410)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
12. 保田浩 (10220154)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
13. 岸輝雄 (40011085)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
14. BROOK R.J.

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
15. AKAZAWA Yoko (50549897)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
16. SAITO Yoshiro (70357060)

# of Collaborated Projects : 1results

# of Collaborated Products : 7results
17. FUTAMURA Shigeru (60165446)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. HASHIMOTO Takehiko (90237941)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. TAKEDA Nobuo (10171646)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. KODAMA Tatsuhiko (90170266)

# of Collaborated Projects : 1results

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21. ABURATANI Hiroyuki (10202657)

# of Collaborated Projects : 1results

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22. EMI Mitsuru (90221118)

# of Collaborated Projects : 1results

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23. DOI Takefumi (00211409)

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24. TAKAHASHI Mareyuki (60280955)

# of Collaborated Projects : 1results

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25. 近藤元治 (80079813)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. 平松緑 (70124790)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. 森昭胤 (20028434)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. 平井俊策 (50010153)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. 浅田浩二 (50027182)

# of Collaborated Projects : 1results

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30. 中野稔 (00008236)

# of Collaborated Projects : 1results

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31. 広部雅昭 (20012594)

# of Collaborated Projects : 1results

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32. 谷口直之 (90002188)

# of Collaborated Projects : 1results

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33. 中澤博江 (20110885)

# of Collaborated Projects : 1results

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34. 一守康史 (60184636)

# of Collaborated Projects : 1results

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35. 沖野遥 (60055689)

# of Collaborated Projects : 1results

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36. 金炳男 (50254149)

# of Collaborated Projects : 1results

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37. 絹見朋也 (90293125)

# of Collaborated Projects : 1results

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38. DERBY B.

# of Collaborated Projects : 1results

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39. BRIGGS G.A.D

# of Collaborated Projects : 1results

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40. MINNICH Anne

# of Collaborated Projects : 1results

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41. TRIGGVASON K

# of Collaborated Projects : 1results

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42. YLAーHERTTUAL セッポ

# of Collaborated Projects : 1results

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43. FREEMAN Maso

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
44. MAEDA Nobuyo

# of Collaborated Projects : 1results

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45. GORDON Siamo

# of Collaborated Projects : 1results

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NIKI Etsuo 二木 鋭雄

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Development and Application of Quantitative Evaluation System for Oxidative Damage of LipidsPrincipal Investigator

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Design and Evaluation of Novel Selenium-Containing AntioxidantPrincipal Investigator

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リポ蛋白質の超分子構造と機能Principal Investigator

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食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator

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フリーラジカルによる細胞の酸化的傷害とその防御機構に関する基礎的研究Principal Investigator

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食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator

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Development, Design and Evaluation of Novel Natural and Synthetic AntioxidantsPrincipal Investigator

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Synthesis of Aromatic Aldehydes and Carboxylic Acids by the Oxidations of Polyaromatic HydrocarbonsPrincipal Investigator

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NIKI Etsuo 二木鋭雄