Niki Etsuo 二木鋭雄

… Alternative Names

Researcher Number	20011033
External Links
Affiliation (Current)	2021: 国立研究開発法人産業技術総合研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2008 – 2009: 独立行政法人産業技術総合研究所, 健康工学研究センター, 顧問 2005 – 2007: 独立行政法人産業技術総合研究所, ヒューマンストレスシグナル研究センター, センター長 2006: National Institute of Industrial Science and Technology (AIST), Human Stress Signal Research Center, Director, ヒューマンストレスシグナル研究センター, 研究センター長 1990 – 1999: 東京大学, 先端科学技術研究センター, 教授 1996: University of Tokyo, Research Center for Advanced Science and Technology, Professor, 先端科学技術センター, 教授 … More
Review Section/Research Field	Principal Investigator 有機工業化学 / Synthetic chemistry / 有機工業化学 Except Principal Investigator 医学一般 / 代謝生物化学 / Eating habits, studies on eating habits / Circulatory organs internal medicine / 広領域 / 医薬分子機能学 / Applied health science
Keywords	Principal Investigator ビタミンE / 脂質過酸化 / 自動酸化 / 抗酸化物 / 抗酸化剤 / 低比重リポタンパク / ヒドロペルオキシド / 抗酸化食品 / トコフェロール / スピンラベル法 … More Except Principal Investigator 活性酸素種 / フリ-ラジカル / 活性酸素 / 酸化ストレスマーカー / ヒドロキシリノール酸 / 酸化ストレス / ビタミンE / コレステロール / 抗酸化物質 / 動脈硬化 / Atherosclerosis / LDL / オキシゲーゼモデル / 光酸化反応 / プロパンの酸化 / 電極触媒酸素酸化 / 不斉エポキシ化 / パーオキソ錯体 / 人工ブレオマイシン / 老化 / SOD / 和漢薬 / 神経細胞障害 / ESR法 / 消化器疾患 / スーパーオキシド / スーパーオキシドジスムターゼ / 酸素障害 / 活性酸素消去酵素 / 酸素ストレス / 脂質過酸化 / NOラジカル / 機能性食品 / ヒドロキシコレステロール / タンパク質酸化修飾 / 酸化DJ-1 / コエンザイムQ / 酸化修飾DJ-1 / トコフェロール / 脂質酸化物 / トコフェリルキノン / グルタチオン / リノール酸 / 酸素酸化 / 酸素類似反応 / 位置選択的水酸化 / ヒドロペルオキシド / 遷移金属錯体触媒 / 光増感酸素酸化 / モノオキシゲナーゼモデル / 選択的酸化反応 / 銅ー酸素錯体 / ブレオマイシン / 再灌流 / ESR / 再潅流 / 創造科学 / 科学文化 / 無機系複合材料 / 日英科学技術史 / 複合材料 / 特性の融合 / 繊維 / 非破壊評価 / 微視構造 / 力学特性 / 損傷 / 科学技術 / Creative Science / Science Culture / Advanced Inorganic Composites / Science History and Policy / スカベンジャー受容体 / ノックアウトマウス / マクロファージ / 酸素ラジカル / Macrophage / Scavenger receptor / Lipoprotein / Cholestrol / Cell Adhesion / 混合培養 / 酸化 / サイトカイン / Co-culture / Oxidation / Antioxidants / Cytokine / タバコ / 活性窒素種 / イソプロスタン / 実験動物 / tobacco / oxidative stress / reactive nitrogen species / oxidative stress marker Less

The study on functional food using oxidative stress marker, hydroxyoctadecadienoic acid and 7-hydroxycholesterol
- Principal Investigator
  
  YOSHIDA Yasukazu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  National Institute of Advanced Industrial Science and Technology
The study on stress induced by tobacco as assessed by oxidative stress marker
- Principal Investigator
  
  YOSHIDA Yasukazu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  National Institute of Advanced Industrial Science and Technology (AIST)
Evaluation of antioxidant activity against atherosclerosis using co-culture system
- Principal Investigator
  
  NOGUCHI Noriko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Research Center for Advanced Science and Technology, University of Tokyo
The Collaboration of International Creative Science and International Science Culture
- Principal Investigator
  
  ENOKI Manabu, 岸輝雄
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  広領域
- Research Institution
  The University of Tokyo
Macrophage scavenger receptors and atherosclerosis
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Research Center for Advanced Sclence and Technology University of Tokyo
Development and Application of Quantitative Evaluation System for Oxidative Damage of LipidsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  有機工業化学
- Research Institution
  The University of Tokyo
Design and Evaluation of Novel Selenium-Containing AntioxidantPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  University of Tokyo
リポ蛋白質の超分子構造と機能Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
フリーラジカルによる細胞の酸化的傷害とその防御機構に関する基礎的研究Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
スーパーオキシド・スーパーオキシドジスムターゼ国際会議開催準備のための総合研究
- Principal Investigator
  
  浅田浩二
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Kyoto University
Development, Design and Evaluation of Novel Natural and Synthetic AntioxidantsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  University of Tokyo, Research Center for Advanced Science and Technology
老化と活性酸素・フリ-ラジカルに関する総合研究
- Principal Investigator
  
  近藤元治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  医学一般
- Research Institution
  Kyoto Prefectural University of Medicine
Synthesis of Aromatic Aldehydes and Carboxylic Acids by the Oxidations of Polyaromatic HydrocarbonsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Synthetic chemistry
- Research Institution
  Research Center for Advanced Science and Technology, The University of Tokyo.
酸素酸化による分子変換
- Principal Investigator
  
  諸岡良彦
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
再灌流時におけるラジカル発生の直接証明
- Principal Investigator
  
  中澤博江
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokai University
Development of Methods for Synthesis of Stereo-Selective Lipid PeroxidesPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Synthetic chemistry
- Research Institution
  UNIVERSITY OF TOKYO
酸素酸化による分子交換
- Principal Investigator
  
  諸岡良彦
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
酸素酸化による分子変換
- Principal Investigator
  
  諸岡良彦
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
A Study on the Action of Antioxidants and Development of SynergistsPrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  The University of Tokyo
Developments of ultra-sensitive analysis of lipid oxidation and evaluation of antioxidant actibity by chemiluminescencePrincipal Investigator
- Principal Investigator
  
  NIKI Etsuo
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  有機工業化学
- Research Institution
  University of Tokyo
食用油脂類の酸化劣化とその抑制に関する研究Principal Investigator
- Principal Investigator
  
  二木鋭雄
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo

All 2009 2008 2007 2006

All Journal Article Presentation Patent

[Journal Article] Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients.2009
- Author(s)
  斉藤芳郎、濱窪隆雄、吉田康一、小川陽子、二木鋭雄
- Journal Title
  
  Nurosciencce Letter Vol.463
  
  Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells.2009
- Author(s)
  斉藤芳郎、小川陽子、吉田康一、二木鋭雄
- Journal Title
  
  Journal of Nutritional Biochemistry Vol.20
  
  Pages: 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells.2009
- Author(s)
  斎藤芳郎, 福原明子, 西尾敬子, 早川三恵子, 小川陽子, 坂本Hirokazu, 藤井健志, 吉田康一, 二木鋭雄
- Journal Title
  
  Journal of Nutritional Biochemistry vol.20
  
  Pages: 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients2009
- Author(s)
  斎藤芳郎, 濱窪隆雄, 吉田康一, 小川陽子(以下省略10人), 二木鋭雄
- Journal Title
  
  Nuroscience Letters vol463
  
  Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Acceleration of lipid peroxidation inα-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator.2008
- Author(s)
  吉田康一, 早川三恵子, Cynshi Osamu, Jishage Kou-ichi, 二木鋭雄
- Journal Title
  
  Journal of Oleo Science vol.57
  
  Pages: 577-583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Gamma-tocopheryl quinine, not alpha-tocopheryl quinine, induces adaptive response through up-regulation of cellular glutathione and cysteine anailability via activation ATF4.2008
- Author(s)
  小川陽子, 斎藤芳郎, 西尾敬子, 吉田康一, 芦田均, 二木鋭雄
- Journal Title
  
  Free Radical Resarch vol.42
  
  Pages: 674-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidativestress induced by selenium deficiency and free radicals2007
- Author(s)
  Saito Y, Yoshida Y, and Niki E
- Journal Title
  
  FEBS Lett 581
  
  Pages: 4349-4354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Cholesterol is more susceptible to oxidation than linolates in cultured cells under oxidative stress induced by selenium deficiebcy and free radicals.2007
- Author(s)
  斎藤芳郎, 吉田康一, 二木鋭雄
- Journal Title
  
  FEBS Letters vol.581
  
  Pages: 4349-4354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Evaluation of Lipophilic Antioxidant Efficacy in vivo by the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane.2007
- Author(s)
  Yoshida Y, Hayakawa M, Habuchi Y, Itoh N, Niki E.
- Journal Title
  
  Lipids 42
  
  Pages: 463-472
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500495
[Journal Article] Antioxidant effects of 2, 3-dihydro-5-hydroxy-4, 6-di-tert-butyl-2, 2-dipentylbenzofur an and a-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.2007
- Author(s)
  吉田康一, 早川三恵子, 伊藤奈々子, 羽渕洋子, 井上ルリ子, Zhi-Hua Chen, Jiaofei Cao, Cynshi Osamu, Jishage Kou-Ichi, 二木鋭雄
- Journal Title
  
  Biochemical Pharmacology vol.74
  
  Pages: 1010-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300256
[Journal Article] Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio.2006
- Author(s)
  Yoshida Y, Hayakawa M, Habuchi Y, Niki E.
- Journal Title
  
  Biochim. Biophys. Acta. 1760
  
  Pages: 1558-1568
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500495
[Patent] 含硫アミノ酸残基が酸化された酸化型ポリペプチドに対する抗体2009
- Inventor(s)
  吉田康一, 斎藤芳郎, 小川陽子, 二木鋭雄, 七里元督, 浜窪隆雄, 望月康弘, 岩成宏子, 絹見直樹
- Industrial Property Rights Holder
  独立行政法人産業技術総合研究所、東京大学、株式会社ペルセウスプロテオミクス
- Industrial Property Number
  2009-028042
- Filing Date
  2009-02-10
- Data Source
  KAKENHI-PROJECT-19300256
[Presentation] 酸化DJ-1とパーキンソン病(2)臨床検体の測定2009
- Author(s)
  小川陽子, 斎藤芳郎, 吉田康一, 二木鋭雄
- Organizer
  第62回日本酸化ストレス学会学術総会
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-19300256
[Presentation] 酸化DJ-1とパーキンソン病(1)抗体作成とELISA開発2009
- Author(s)
  斎藤芳郎, 小川陽子, 吉田康一, 二木鋭雄
- Organizer
  第62回日本酸化ストレス学会学術総会
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-19300256

1. YAMAMOTO Yorihiro (60134475)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. NOGUCHI Noriko (40198578)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. 斎藤烈 (20026082)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 諸岡良彦 (70016731)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 安藤亘 (30008429)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 杉本豊成 (30093256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 今中利信 (30029417)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. YOSHIDA Yasukazu (90358333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
9. ENOKI Manabu (70201960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TSUCHIYA Jyunichi (40011051)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 吉川敏一 (90158410)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 保田浩 (10220154)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 岸輝雄 (40011085)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. BROOK R.J.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. AKAZAWA Yoko (50549897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
16. SAITO Yoshiro (70357060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. FUTAMURA Shigeru (60165446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HASHIMOTO Takehiko (90237941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TAKEDA Nobuo (10171646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KODAMA Tatsuhiko (90170266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ABURATANI Hiroyuki (10202657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. EMI Mitsuru (90221118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. DOI Takefumi (00211409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TAKAHASHI Mareyuki (60280955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 近藤元治 (80079813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 平松緑 (70124790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 森昭胤 (20028434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 平井俊策 (50010153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 浅田浩二 (50027182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 中野稔 (00008236)

# of Collaborated Projects: 1 results

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31. 広部雅昭 (20012594)

# of Collaborated Projects: 1 results

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32. 谷口直之 (90002188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 中澤博江 (20110885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 一守康史 (60184636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 沖野遥 (60055689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 金炳男 (50254149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 絹見朋也 (90293125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. DERBY B.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. BRIGGS G.A.D

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. MINNICH Anne

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. TRIGGVASON K

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. YLAーHERTTUAL セッポ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. FREEMAN Maso

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. MAEDA Nobuyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. GORDON Siamo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Niki Etsuo 二木 鋭雄

NIKI Etsuo 二木 鋭雄

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Development and Application of Quantitative Evaluation System for Oxidative Damage of LipidsPrincipal Investigator

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Design and Evaluation of Novel Selenium-Containing AntioxidantPrincipal Investigator

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リポ蛋白質の超分子構造と機能Principal Investigator

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食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator

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フリーラジカルによる細胞の酸化的傷害とその防御機構に関する基礎的研究Principal Investigator

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食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計Principal Investigator

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Development, Design and Evaluation of Novel Natural and Synthetic AntioxidantsPrincipal Investigator

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Synthesis of Aromatic Aldehydes and Carboxylic Acids by the Oxidations of Polyaromatic HydrocarbonsPrincipal Investigator

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Niki Etsuo 二木鋭雄

NIKI Etsuo 二木鋭雄