KUBOTA Nobuo 窪田宜夫

… Alternative Names

窪田宣雄クボタノブオ

窪田宜夫クボタノブオ

窪田宣夫クボタノブオ

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Researcher Number	20046139
External Links
Affiliation (based on the past Project Information) *help	2002 – 2013: 茨城県立医療大学, 保健医療学部, 教授 2000: Ibaraki Prefectural University of Health Sciences, Department of Radiological Sciences, Professor, 保健医療学部, 教授 1997 – 1999: 茨城県立医療大学, 保健医療学部, 助教授 1994: Yokohama City University, Radiology, Lecturer, 医学部, 講師 1992: 横浜市立大学, 医学部・放射線医学教室, 講師 1991 – 1992: 横浜市立大学, 医学部, 講師 1988 – 1990: 横浜市立大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Radiation science / Radiation science / 環境影響評価(含放射線生物学) Except Principal Investigator Radiation science / Radiation science
Keywords	Principal Investigator 放射線増感 / アポトーシス / Apaf-1 / Hsp90 / PI3K-Akt / 17AAG / GA / Radiosensitization / PI 3-kinase / DNA-PK … More / V79 / HPRT / sulforaphane / ヒト腫瘍細胞 / apoptosis / pancreatic cell line / Sulforaphane / Rdiosensitization / Bcl-2 / apigenin / 放射線増感効果 / 生存シグナル / 膵臟がん / 膵臓がん / Spheroid / Apoptosis / スフェロイド / Akt / PI3K / geldanamycin / 多細胞スフェロイド / HSP90 / low-pH / Tumor microenvironment / Wortmanni / DNA二重鎖切断 / wortmannin / 低pH / 腫瘍内微小環境因子 / PI3-kinase / Wortmannin / Neutron energy / Mutation / Neutron / クロマチン損傷 / 中性子線 / 突然変異 / エネルギー依存性 / 中性子 / ＤＮＡ修復 / celastrol / がん幹細胞様細胞 / Celastrol / Hsp90阻害剤 / DNA二本鎖切断修復 / セラストロール / ベンチルイソチオシアネート / フィトケミカル / DNA修復阻害 / Sufforaphane / DNA二重鎖切断修復 / Cyclin-dependent kinase / XIAP / 膵臓癌細胞 / Benthyl isothiocyanate / sulforahane / イソチオシアネート / CDK阻害剤 … More Except Principal Investigator 癌遺伝子 / 骨肉腫 / 放射線抵抗性癌 / Homologous recombination repair / Rad51 / siRNA / BRCA2 / 17AAG / p53 / raf / 悪性黒色腫 / PLDR / Cells / C3H 10T1 / Repair / Potentially Lethal Damage / Sublethal Damage / Multiple-Dose Irradiation / C3HlOT1@2 / PLD repair / SLD repair / 2細胞 / C3H10T1 / 修復 / 潜在的致死障害 / 亜致死障害 / 多分割照射 / DNA DSB repair / Hsp90 inhibitor / Radio-sensitization / DNA ligase IV / RNA干渉 / 非相同末端結合 / 正常細胞 / 癌細胞 / アポトーシス / DNA-PKcs / non-homologous end joining / 放射線抵抗性 / 17-AAG / DNA DSB修復 / 放射線増感材 / 相同組み換え修復 / DNA DSB 修復 / HSP90阻害剤 / 放射線増感剤 / Deprh-dose distribution / Iodine-based contrast medium / Secondary electrons / High energy electrons / Cell Killing / Radiation-induced chromosome aberrations / 深部線量分布 / 生物学的線量計 / ヨード系造影剤 / 放射線誘発染色体異常 / ヨード造影剤 / X線エネルギー / 線量増強効果 / 2次電子 / 電子線 / 染色体異常 / PLD / PCNA / SLDR / ras / ファイブロサルコ-マ Less

Radiosensitization of human tumor cells by phytochemicalsPrincipal Investigator
- Principal Investigator
  
  NOBUO Kubota
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Ibaraki Prefectural University of Health Science
Radiosensitization by cyclin-dependent kinase inhibitors and its molecular mechanismPrincipal Investigator
- Principal Investigator
  
  KUBOTA Nobuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Ibaraki Prefectural University of Health Science
Radiosensitization by inhibition of cell survival signalPrincipal Investigator
- Principal Investigator
  
  KUBOTA Nobuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Ibaraki Prefectural University of Health Science
Research for radio-sensitizers which specifically attack tumor cells
- Principal Investigator
  
  RYUICHI Okayasu
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
Radiosensitization by inhibition of Hsp90 and microenvironmental factorsPrincipal Investigator
- Principal Investigator
  
  KUBOTA Nobuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Ibaraki Prefectural University of Health Science
Radiosensitization by inhibiting DNA-protein kinase and microenvironmental factorPrincipal Investigator
- Principal Investigator
  
  KUBOTA Nobuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Ibaraki Prefectural University of Health Sciences
Studies on energy dependency of biological effects of neutrons and risk estimationPrincipal Investigator
- Principal Investigator
  
  KUBOTA Nobuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Ibaraki Prefectural University of Health Sciences
放射線抵抗性癌の成因とその増感
- Principal Investigator
  
  内海博司
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Chromosome aberration induction and cell killing induced by electrons of various energy levels.
- Principal Investigator
  
  MATSUBARA Sho
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Yokohama City Univ.
放射線抵抗性がんの成因とその増感
- Principal Investigator
  
  内海博司
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
放射線抵抗性癌の成因とその増感
- Principal Investigator
  
  内海博司
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Effect of Multiple-Dose Irradiation on Cultured Mammalian Cells
- Principal Investigator
  
  MATSUI Kengo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Yokohama City University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] 放射線生物学2008
- Author(s)
  窪田宜夫, 他
- Total Pages
  100
- Publisher
  医療出版社
- Data Source
  KAKENHI-PROJECT-20591497
[Book] 放射線生物学2008
- Author(s)
  窪田宜夫
- Total Pages
  128
- Publisher
  医療科学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591388
[Book] 放射線生物学2008
- Author(s)
  窪田宜夫
- Total Pages
  128
- Publisher
  医療科学社
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H712014
- Author(s)
  Segawa T, Kubota N, et al.
- Journal Title
  
  Int J Mol Med
  
  Volume: 33 Issue: 3 Pages: 559-564
- DOI
  10.3892/ijmm.2013.1594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845
[Journal Article] Radiosensitization of human lung cancer cells by the novel purine-scaffold Jsp90 inhibitor(PU-H71)2014
- Author(s)
  Segawa T, Fujii Y, Tanaka A, Band SI, Okayasu R, Onishi K, Kubota N
- Journal Title
  
  Int J Mol Med
  
  Volume: 33 Pages: 559-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845
[Journal Article] Comparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks2013
- Author(s)
  Fujii Y, Genet MD, Roybal EJ, Kubota N, Okayasu R, Fujimori A, Mori T, Mauro K, Kato TA
- Journal Title
  
  Oncol Rep
  
  Volume: 29 Issue: 6 Pages: 2133-2139
- DOI
  10.3892/or.2013.2354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845, KAKENHI-PROJECT-24249067, KAKENHI-PROJECT-24390289
[Journal Article] Comparative study of radioresistance between feline cells and human cells2013
- Author(s)
  Fujii Y, Yurkon CR, Maeda J, Genet SC, Kubota N, Fujimori A, Mori T, Mauro K, Kato TA
- Journal Title
  
  Radiat Res
  
  Volume: 180 Issue: 1 Pages: 70-77
- DOI
  10.1667/rr3194.1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845
[Journal Article] 植物由来天然整理活性物質フィトケミカルの放射線増感作用2012
- Author(s)
  板東真一、窪田宜夫、大西健
- Journal Title
  
  放射線生物研究
  
  Volume: 47 Pages: 46-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845
[Journal Article] Hsp90 inhibitors are promising radiosensitizers for radiotherapy2012
- Author(s)
  Kubota N, Matsumoto Y
- Journal Title
  
  Thermal Med
  
  Volume: 28 Pages: 53-62
- NAID
  10031143335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845
[Journal Article] Hsp90 inhibitors are promising radiosensitizes for radiotherapy.2012
- Author(s)
  Nobuo Kubota and Yoshitaka Matsumoto
- Journal Title
  
  Thermal Med
  
  Volume: 28 Pages: 53-62
- NAID
  10031143335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845
[Journal Article] Benzylisothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis2011
- Author(s)
  Ohara M, Kimura S, Tanaka A, Onishi K, Okayasu R, Kubota N
- Journal Title
  
  Int J Mol Med
  
  Volume: 28 Pages: 1043-1047
- DOI
  10.3892/ijmm.2011.770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591845
[Journal Article] Okayasu R, p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor17-allylamino-17-demethoxygeldanamy cin.2010
- Author(s)
  Fujii Y, Kato T, Kubota N, Fujimori A
- Journal Title
  
  Oncol Rep 23(1)
  
  Pages: 199-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Journal Article] Ascorbic acid gives different protective effects in human cells exposed to X-rays and heavy ions.2010
- Author(s)
  Fujii Y, Kato T, Ueno A, Kubota N, Fujimori A, Okayasu R
- Journal Title
  
  Mutat Res 699(1-2)
  
  Pages: 58-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Journal Article] Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells.2009
- Author(s)
  Yu D, Sekine-Suzuki E, Xue L, Kubota N, Okayasu R
- Journal Title
  
  Int J Cancer 125(5)
  
  Pages: 1205-1211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Journal Article] Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells.2008
- Author(s)
  Sekine-Susuki E, Yu D, Kubota N, Okayasu R, Anzai K
- Journal Title
  
  Biochem Biopyy Res Com 377
  
  Pages: 341-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Journal Article] NBS1 regulates a novel apoptotic pathway through Bax activation.2008
- Author(s)
  Iijima K, Muranaka C, Kobayashi J, SakamotoS, Komatsu K, Matsuura S, Kubota N, Tauchi H
- Journal Title
  
  DNA Repair 7
  
  Pages: 1705-1716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Journal Article] NBS1 regulates a novel apoptotic pathway through Bax activation. DNA Repair 2008 : 7 : 1705-17162008
- Author(s)
  Iijima K, Muranaka C, Kobayashi J, Sakamotos, Komatsu K, Matsuura S, Kubota K, Tauchi H
- Journal Title
  
  DNA Repair 7
  
  Pages: 1705-1716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Journal Article] Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells.2008
- Author(s)
  Sekine-Susuki E, Yu D, Kubota N, Okayasu R, Anzai K
- Journal Title
  
  Biochem Biophys Res Com 377(2)
  
  Pages: 341-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Journal Article] The chemopreventive flavonoid apigeninconfers radiosensitizing effectin human tumor cells grown as monolyer s and spheroids2007
- Author(s)
  Norihiro, Watanabe, Ryoichi, Hirayama, Nobuo, Kubota
- Journal Title
  
  J Radiat Res 48
  
  Pages: 45-50
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] The chemopreventive flavonoid apigeninconfers radiosensitizing effectin human tumor cells grown as monolyer s and spheroids2007
- Author(s)
  Norihiro Watanabe, Ryoichi Hirayama, Nobuo Kubota
- Journal Title
  
  J Radiat Res 48
  
  Pages: 45-50
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] The chemopreventive flavonoid apigeninconfers radiosensitizing effectin human tumor cells grown as monolyer s and spheroids.2007
- Author(s)
  Norihiro Watanabe, Ryoichi Hirayama, Nobuo Kubota
- Journal Title
  
  J Radiat Res 48
  
  Pages: 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] The chemopreventive flavonoid apigenin confers radiosensitizing effect in human tumor cells grown as monolayers and spheroids.2007
- Author(s)
  Norihiro Watanabe, Ryoichi Hirayama, Nobuo Kubota
- Journal Title
  
  J Radiat Res 48(1)
  
  Pages: 45-50
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.2006
- Author(s)
  Noguchi M, Yu D, Hirayama R, Ninomiya Y, Sekine E, Kubota N, Ando K, Okayasu R.
- Journal Title
  
  Biochemistry Biophysics Research Communications 351
  
  Pages: 658-663
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16209036
[Journal Article] Heat shock protein 90 inhibitor geldanamycin and 17AAG as anti-cancer therapeuticagents.2006
- Author(s)
  Nobuo Kubota, Yoshitaka Matsumoto, Hikaru Machida
- Journal Title
  
  Jpn J Hyperthermic Oncol 22
  
  Pages: 201-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Heat shock protein 90 inhibitor geldanamycin and 17AAG as anti-cancer therapeutic agents2006
- Author(s)
  Nobuo Kubota, Yoshitaka Matsumoto, Hikaru Machida
- Journal Title
  
  Jpn J Hyperthermic Oncol 22
  
  Pages: 201-210
- NAID
  10019596792
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxy-Geldanamycin.2006
- Author(s)
  Miho Noguchi, Nobuo Kubota, et al.
- Journal Title
  
  Biochem Biophys Res Commun 351
  
  Pages: 658-663
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.2006
- Author(s)
  Noguchi M, Yu D, Hirayama R, Ninomiya Y, Sekine E, Kubota N, Ando K, Okayasu R.
- Journal Title
  
  Biochem Biophys Res Commun 351
  
  Pages: 658-663
- Data Source
  KAKENHI-PROJECT-16209036
[Journal Article] Heat shock protein 90 inhibitor geldanamycin and 17AAG as anti-cancer therapeutic agents2006
- Author(s)
  Nobuo Kubota, et al.
- Journal Title
  
  Jpn J Hyperthermic Oncol 22(4)
  
  Pages: 201-210
- NAID
  10019596792
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Inhibition of homologous recombination repair in irreadiated tumor cells pretreated with Hsp90 inhibiotr 17-allylamino-17-demethoxygeldanamycin.2006
- Author(s)
  Noguchi M, Yu D, Hirayama R, Ninomiya Y, Sekine E, Kubota N, Ando K, Okayasu R
- Journal Title
  
  Biochem Biophys Res Commun 351
  
  Pages: 658-663
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Inhibition of Homologous Recombination Repair in Irradiated Tumor Cells Pretreated with Hsp90 Inhibitor 17-Allylamino-17-demethoxygeldanamycin.2006
- Author(s)
  Noguchi, M, Yu, D., Hirayama, R., Ninomiya, Y., Sekine, E., Kubota, N., Ando, K. Okayasu, R.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 351
  
  Pages: 658-663
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209036
[Journal Article] Heat shock protein 90 inhibitor geldanamycin and 17AAG as anti-cancer therapeutic agents2006
- Author(s)
  Nobuo, Kubota, Yoshitaka, Matsumoto, Hikaru, Machida
- Journal Title
  
  Jpn J Hyperthermic Oncol 22
  
  Pages: 201-210
- NAID
  10019596792
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Inhibition of homologous recombination repair inrreadiated tumor cells pretreated with Hsp90 inhibiotr 17-allylamino-17-demethoxygeldanamycin2006
- Author(s)
  Noguchi, M., Yu, D., Hirayama, R., Ninomiya, Y., Sekine, E., Kubota, N., Ando, K., Okayasu, R
- Journal Title
  
  Biochem Biophys Res Commun 351
  
  Pages: 658-663
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591388
[Journal Article] Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD1.2005
- Author(s)
  Iimuro, R, Takahashi, S, Ito, H, Kubota, Y, Suetomi, K, Sato, H, Okayasu, R.
- Journal Title
  
  Journal of Radiation Research 46
  
  Pages: 67-73
- NAID
  110004041097
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16209036
[Journal Article] Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD12005
- Author(s)
  Iimuro, R, Takahashi, S, Ito, H, Kubota, Y, Suetomi, K, Sato, H, Okayasu, R.
- Journal Title
  
  J. Radiat. Res. 46
  
  Pages: 67-73
- NAID
  110004041097
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209036
[Journal Article] Preferential sensitization of tumor cells to radiation by inhibition of Heat Shock protein 902005
- Author(s)
  Yoshitaka Matsumoto, Hikaru Machida, Nobuo Kubota
- Journal Title
  
  J. radiat. Res. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] Preferential sensitization of tumor cells to radiation by inhibition of Heat shock protein 902005
- Author(s)
  Yoshitaka Matsumoto, Hikaru Machida, Nobuo Kubota
- Journal Title
  
  J.Radiat.Res. 46(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] Hsp90 inhibitor sensitizsz human tumor cells to radiation2004
- Author(s)
  Kubota, N., Matsumoto, Y., Machida, H.
- Journal Title
  
  jpn. J. Cancer Clin. 50
  
  Pages: 1061-1065
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] 細胞レベルでの時間と空間-Hso90分子シャペロンの阻害による放射線増感-2004
- Author(s)
  窪田宜夫, 松本孔貴, 町田光
- Journal Title
  
  癌の臨床 50
  
  Pages: 1061-1065
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] 細胞レベルでの時間と空間-Hsp90分子シャペロンの阻害による放射線増感-2004
- Author(s)
  窪田宜夫
- Journal Title
  
  癌の臨床 50(13)
  
  Pages: 1061-1065
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] DNA修復阻害による放射線増感2003
- Author(s)
  窪田宜夫, 町田光, 岡田忍
- Journal Title
  
  日放腫会誌 15
  
  Pages: 1-7
- NAID
  10020583942
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] Geldanamycin, an inhibitor of Hso90, sensitizes human tumor cells to radiation2003
- Author(s)
  H.Machida, Y.Matsumoto, M.Shirai, N.Kubota
- Journal Title
  
  Int. J. Radiat. Biol. 79
  
  Pages: 973-980
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] Geldanamycin, an inhibitor of Hsp9O, sensitizes human tumor cells to radiation.2003
- Author(s)
  H.Machida, Y.Matsumoto, M.Shirai, N.Kubota
- Journal Title
  
  Int.J.Radiat.Biol. 79
  
  Pages: 973-980
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] DNS修復阻害による放射線増感2003
- Author(s)
  窪田宜夫
- Journal Title
  
  日放腫会誌 15
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] Radiosensitization by DNA reapir inhibitor in human tumor cells2003
- Author(s)
  Nobuo Kubota, Hikaru Machida, Shinobu Okada
- Journal Title
  
  J. Jpn. Soc. Ther. Radial. Oncol 15
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370283
[Journal Article] Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation.
- Author(s)
  Kuribayashi T, Ohara M, Sora S, Kubota N
- Journal Title
  
  Int J Mol Med 201,25(1)
  
  Pages: 25-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] スフェロイドに発現するCD133陽性細胞の放射線感受性2014
- Author(s)
  大西健、窪田宜夫、他
- Organizer
  第16回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] スフェロイドに出現すCD133陽性細胞の放射線感受性2014
- Author(s)
  大西健、窪田宜夫、他
- Organizer
  第16回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Comparative study of radioresistance between feline and human cells.2013
- Author(s)
  Yoshihiro Fujii, Nobuo Kubota, et al
- Organizer
  第56回日本放射線影響学会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Hsp90阻害剤と放射線の併用による転移抑制効果2013
- Author(s)
  李恵子、窪田宜夫、他
- Organizer
  第15回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Hsp90をターゲットとした放射線増感2013
- Author(s)
  窪田宜夫
- Organizer
  15回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Invited
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Hsp90阻害剤と炭素線の併用による細胞致死および転移抑制効果2013
- Author(s)
  李恵子、窪田宜夫、他
- Organizer
  第56回日本放射線影響学会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Hsp90をターゲットとした放射線増感2013
- Author(s)
  窪田宜夫
- Organizer
  第15回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Invited
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] スフェロイド低酸素微小環境に依存したCD133発現の可塑的変化2013
- Author(s)
  谷敏明、窪田宜夫、他
- Organizer
  第11回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] 神経膠芽腫細胞T98Gの単層培養ースフェロイド間でみられるCD133陽性細胞の可塑的な誘導2013
- Author(s)
  大西健、窪田宜夫、他
- Organizer
  第56回日本放射線影響学会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] グリオブラストーマスフェロイド内低酸素微小環境とCD133陽性細胞の誘導2013
- Author(s)
  大西健、窪田宜夫、他
- Organizer
  第72回日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Comparative study of radioresistance between feline and human cells2013
- Author(s)
  Yoshihro Jujii, Nobuo Kubota, et al
- Organizer
  第56回日本放射線影響学会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] 神経膠芽腫細胞T98Gの単層培養―スフェロイド間で見られるCD133陽性細胞の可塑的な誘導2013
- Author(s)
  大西健、窪田宜夫、他
- Organizer
  第56回日本放射線影響学会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] フラボノイドAに新規に三井田冴えた放射線増感作用の作用機序の解析2012
- Author(s)
  板東真一、窪田宜夫、他
- Organizer
  第55回日本放射線影響学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Chromosome aberrations of the first responders followed by Fukushima Daiichi Neclear accident.2012
- Author(s)
  FUJII Yoshihiro, KUBOTA Nobuo, et al
- Organizer
  第５５回日本放射線影響学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] 分子シャペロンHsp90をターゲットとする放射線増感2012
- Author(s)
  窪田宜夫
- Organizer
  第55回日本放射線影響学会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] フラボノイドAに新規に見出された放射線増感作用の作用機序の解析2012
- Author(s)
  坂東真一、窪田宜夫、他
- Organizer
  第５５回日本放射線影響学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] 分子シャペロンHsp90をターゲットとする放射線増感2012
- Author(s)
  窪田宜夫
- Organizer
  第５５回日本放射線影響学会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] 新規Hsp90阻害剤PU-H71の放射線増感メカニズムについて2012
- Author(s)
  瀬川達矢、窪田宜夫、他
- Organizer
  第14回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Chromosome aberrations of the first responders followed by FUKUSHIMA DAIICHI Nuclear accident2012
- Author(s)
  Yoshihiro Fujii, Nobuo Kubota, et al
- Organizer
  第55回日本放射線影響学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] Hsp90阻害剤Celastrolのヒト腫瘍細胞の放射線増感とp53 status2011
- Author(s)
  瀬川達矢、窪田宜夫、他
- Organizer
  第24回日本放射線腫瘍学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23591845
[Presentation] 放射線増感作用を示す植物生理活性物質、特にフラボノイドの分子標的放射線増寒剤としての有用性2011
- Author(s)
  大西健, 窪田宜夫, 竹森洋, 秦野修
- Organizer
  第13回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] Hsp90阻害剤Celastrolのヒト腫瘍細胞の放射線増感2011
- Author(s)
  瀬川達矢, 田中彩, 大西健, 窪田宜夫
- Organizer
  第13回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] 抗がん作用を持つフラボノイド類のスクリーニング2010
- Author(s)
  大西健, 窪田宜夫, 秦野修, 竹森洋
- Organizer
  第53回日本放射線影響学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] 抗がん作用を持つフラボノイド類のスクリーニング2010
- Author(s)
  大西健、窪田宜夫, ほか
- Organizer
  日本放射線影響学会
- Place of Presentation
  京都
- Year and Date
  2010-10-20
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] Isothiocyanate類によるヒト腫瘍細胞の放射線増感2010
- Author(s)
  窪田宜夫, 田中彩, 干冬, 岡安隆一
- Organizer
  第12回癌治療増感研究シンポジウム
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] ヒト腫瘍細胞におけるBenzyl Isothiocyanateの放射線増感に関する研究2009
- Author(s)
  窪田宜夫、大原麻希、木村慎一、関根恵美子、于冬、岡安隆一
- Organizer
  第48回日本医学放射線学会生物部会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] ヒト腫瘍細胞でのイソチオシアネートによる放射線増感2009
- Author(s)
  大原麻希、木村慎一、窪田宜夫、田内広
- Organizer
  平成21年度日本原子力学会北関東支部若手研究者発表会
- Place of Presentation
  水戸
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] DNA損傷修復経路によるスルフォラファンの放射線腫瘍増感作用2008
- Author(s)
  于冬、関根絵美子、師連、藤森亮、窪田宜夫、岡安隆一
- Organizer
  第51回日本放射線影響学会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] ヒト腫瘍細胞でのbenzyl isothiocyanateの放射線増感効果2008
- Author(s)
  大原麻希、木村慎一、窪田宜夫
- Organizer
  第51回日本放射線影響学会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] スルフォラファンと重粒子線との併用における放射線増感による抗腫瘍効果の検討2008
- Author(s)
  関根絵美子、于冬、二宮康晴、窪田宜夫、藤森亮、岡安隆一、安西和記
- Organizer
  第51回日本放射線影響学会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] スルフォラフアンと重粒子線との併用における放射線増感による抗腫瘍効果の検討2008
- Author(s)
  関根絵美子, 于冬, 二宮康晴, 窪田宜夫, 藤森亮, 岡安隆一, 安西和記
- Organizer
  第51回日本放射線影響学会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] ヒト腫瘍細胞でのbenzyl isothiocyanateの放射線増感効果第51回日本放射線影響学会(北九州)2008年11月2008
- Author(s)
  大原麻希, 木村慎一, 窪田宜夫
- Organizer
  第51回日本放射線影響学会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-20591497
[Presentation] ヒト腫瘍細胞でのSulforaphaneの放射線増感効果2007
- Author(s)
  窪田宜夫、他
- Organizer
  第20回日本放射線腫瘍学会
- Data Source
  KAKENHI-PROJECT-18591388
[Presentation] ヒト腫瘍細胞でのSulforaphaneの放射線増感効果2007
- Author(s)
  窪田宜夫, 他
- Organizer
  第20回日本放射線腫瘍学会
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591388
[Presentation] Radiosensitization by sulforaphane in human Tumor cells2007
- Author(s)
  Kubota, N., et. al.
- Organizer
  20th Japanese Society for Therapeutic Radiology and Oncology
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591388
[Presentation] スフェロイドの低酸素微小環境に依存したCD133発現の可塑的変化
- Author(s)
  谷俊明、窪田宜夫、他
- Organizer
  第11回がんとハイポキシア研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591845

1. 内海博司 (20025646)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 佐々木武仁 (90013896)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 石崎寛治 (70111987)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SHIKANO Naoto (80295435)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. RYUICHI Okayasu (50356135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
6. 小坂俊之 (90215228)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 大西武雄 (60094554)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OHNISHI Ken (50152195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. FUJII Yoshihro (20637540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. MATSUBARA Sho (40014120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOMATSU Kenshi (80124577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SIZUKI Masao (70281673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. INADA Tetsuo (50114038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMADA Shigeru (80311380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUI Kengo (60117760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小野公二 (90122407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 馬嶋秀行 (60165701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 安藤興一 (00159526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. OHARA Maki

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. TANAKA Aya

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

KUBOTA Nobuo 窪田 宜夫

窪田 宣雄 クボタ ノブオ

窪田 宜夫 クボタ ノブオ

窪田 宣夫 クボタ ノブオ

Research Projects

Research Products

Co-Researchers

Radiosensitization of human tumor cells by phytochemicalsPrincipal Investigator

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Radiosensitization by cyclin-dependent kinase inhibitors and its molecular mechanismPrincipal Investigator

Principal Investigator

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Radiosensitization by inhibition of cell survival signalPrincipal Investigator

Principal Investigator

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Research for radio-sensitizers which specifically attack tumor cells

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Radiosensitization by inhibition of Hsp90 and microenvironmental factorsPrincipal Investigator

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Radiosensitization by inhibiting DNA-protein kinase and microenvironmental factorPrincipal Investigator

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Studies on energy dependency of biological effects of neutrons and risk estimationPrincipal Investigator

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放射線抵抗性癌の成因とその増感

Principal Investigator

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Chromosome aberration induction and cell killing induced by electrons of various energy levels.

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放射線抵抗性がんの成因とその増感

Principal Investigator

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放射線抵抗性癌の成因とその増感

Principal Investigator

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Effect of Multiple-Dose Irradiation on Cultured Mammalian Cells

Principal Investigator

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[Book] 放射線生物学2008

Author(s)

Total Pages

Publisher

KUBOTA Nobuo 窪田宜夫

窪田宣雄クボタノブオ

窪田宜夫クボタノブオ

窪田宣夫クボタノブオ